Cancer Weekly articles from August 2004

Cancer Weekly archives from August 2004

Sexual behavior changes may explain rising incidence of anal cancer.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- Anal cancer is on the rise in both sexes, particularly among American men, and changing trends in sexual behavior - combined with current tobacco use and infection by a specific strain of the human...

Statins promote collateral neovascularization without causing cancer growth.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- Statins promote collateral neovascularization without causing cancer growth. According to a study from Japan, "3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, or statins, are widely...

Virus linked to aggressive forms of disease.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- A new study finds increasing evidence a virus may play a role in breast cancer. Researchers reported that nearly three-quarters of a small sample of Tunisian breast cancer patients showed evidence...

Low-dose metronomic cyclophosphamide offers advantages to cancer patients.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- Low-dose metronomic cyclophosphamide offers advantages to cancer patients. According to recent research published in the journal Cancer Research, "the survival benefits of traditional maximum...

Estrogen is an angiogenic switch in human breast cancers.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- Estrogen is an angiogenic switch in human breast cancers. "Estrogen is involved in breast tumorigenesis, but the precise mechanisms for its oncogenic and angiogenic actions are poorly understood....

Novel FLT3 inhibitors may be considered to treat hyperdiploid or relapsed ALL.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- Novel FLT3 inhibitors may be considered for the treatment of hyperdiploid or relapsed acute lymphoblastic leukemia. "Activating mutations of the FLT3 receptor tyrosine kinase are common in acute...

FLT3 mutations in AML adversely associate with CR with intensive chemotherapy.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- FLT3 mutations are adversely associated with complete remission in AML patients given intensive chemotherapy. "The prognostic impact of FLT3 mutations on the outcome of patients with diploid AML,...

Factors affecting good and poor CD34+ cell mobilization in AML determined.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- The factors affecting good and poor CD34+ cell mobilization in AML have been determined. According to a study from Italy, "The factors possibly affecting the collection of peripheral blood stem...

Timed sequential therapy for AML patients over 60 tolerated but unsatisfactory.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- Timed sequential therapy for acute myeloid leukemia patients over 60 was well tolerated but unsatisfactory. "Acute myeloid leukemia (AML) in the elderly is a serious problem characterized by poor...

Malignant adipose tissue tumors reviewed.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- Researchers review malignant adipose tissue tumors in a recent issue of the Bulletin du Cancer. "Malignant adipose tissue tumors, also called liposarcomas, are the most common Sarcoma of adult...

STI571 and taxol target skeletal compartment tumor-associated cells.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- STI571 and taxol target skeletal compartment tumor-associated cells. According to recent research from the United States, "the activation of the microvascular endothelial cell platelet-derived...

P300 regulates p53-dependent apoptosis in colorectal cancer cells.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- P300 nucleoprotein regulates p53-dependent apoptosis in colorectal cancer cells. "Activation of the tumor suppressor p53 by DNA damage induces either cell cycle arrest or apoptosis, but what...

Serum pepsinogens predict topography of intestinal metaplasia.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- Serum pepsinogen levels can be used to predict intestinal metaplasia topography in atrophic gastritis patients. "The importance of atrophic gastritis with intestinal metaplasia is related to the...

Non-electrophoretic assays screen for chemical inhibitors of DNA ligase.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- Non-electrophoretic assays screen for chemical inhibitors of DNA ligase. "A new rapid assay method for DNA ligases has been developed, which allows direct quantification of enzyme activity without...

BLM and CAF-1 coordinate to promote survival in response to DNA damage.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- BLM and CAF-1 coordinate to promote survival in response to DNA damage. According to recent research published in the journal Molecular and Cellular Biology, "Bloom's syndrome (BS) is a genomic...

Local gene therapy improves bone deposition during distraction osteogenesis.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- Local gene therapy improves bone deposition during distraction osteogenesis. "Distraction osteogenesis (DO) requires a long consolidation period and has a low but real failure rate. Bone morphogenic...

Vaccine targeting cancer-related antigens appears to prolong survival.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- Researchers seeking to direct cancer-killing immune cells against the deadliest brain tumors have three new targets that show promise in laboratory studies and in a Phase I patient trial, according to...

Alliance formed to increase access to partial breast irradiation.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- Varian Medical Systems, Inc. (VAR) and Proxima Therapeutics, Inc. have formed an alliance to increase access to high-dose-rate radiation (HDR) therapy equipment for hospitals interested in offering...

Cancer therapeutics development company files IND for metastatic breast cancer.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- NeoRx Corporation (Nasdaq:NERX) announced that it has filed an Investigational New Drug (IND) application with the U.S. Food and Drug Administration (FDA) for a phase II clinical study of STR (skeletal...

Collaboration to study advanced breast imaging applications.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- Hologic, Inc., (HOLX) has entered into a collaborative research agreement with the David Geffen School of Medicine at the University of California at Los Angeles (UCLA) to study a variety of advanced...

Denoising algorithm reduces radiation exposure.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- University of Rochester, New York, radiologists have proposed a denoising algorithm that reduces radiation exposure of a patient undergoing cone-beam computed tomography scan for breast cancer while...

ER codon 594/HER2 codon 655 polymorphisms not associated with breast cancer risk.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- ER codon 594 and HER2 codon 655 polymorphisms are not associated with an increased breast cancer risk. According to a study from Turkey, "The estrogen receptor (ER) and the human epithelial growth...

Effect of high-n-6 fat diet on gene expression determined.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- Genes differentially expressed during a carcinogenic high-n-6 fat diet have been identified using microarray analysis. "In previous studies," oncologists in Spain "demonstrated that high corn oil...

Endocrinological underpinnings elucidated.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- The endocrinological factors underlying breast cancer have been elucidated. "In breast tumors and breast cancer cell (BCC) lines, microarray analyses have revealed that a series of genes are...

FDA completes review of digital mammography system.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- Siemens Medical Solutions has received an approvable letter from the U.S. Food & Drug Administration (FDA) for the MAMMOMAT NovationDR, a full-field digital mammography system. This letter indicates...

In vivo TLD dosimetry possible in mammography.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- Scientists in Australia say that in vivo adjustment in radiation dose for women undergoing mammography is possible using thermoluminescent dosimeters. "While phantoms are used for quality control...

Increased serum folate levels associated with reduced breast cancer risk.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- Increased serum folate levels are associated with reduced breast cancer risk. "Breast cancer risk may be associated with folate status or the C677T genotype of the methylenetetrahydrofolate...

Light-to-moderate drinking appears to have little effect on disease risk.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- In an effort to clarify the relationship between alcohol consumption and the risk of developing breast cancer, a study in the July 2004 issue of Alcoholism: Clinical & Experimental Research examines the...

Novel phosphorylation sites in HMGN1 protein from breast cancer cells identified.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- Novel phosphorylation sites in high-mobility group N1 protein from breast cancer cells have been identified. According to recent research published in the journal Biochemistry, "High-mobility group...

Radiolabeled peptide shows promise for diagnosis.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- A novel radiolabeled peptide may facilitate diagnosis of breast cancer. "In an effort to develop a peptide-based radiopharmaceutical for the detection of breast cancer," scientists in Saudi Arabia...

SLN biopsy predicts axillary lymph node status in male breast cancer patients.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- Researchers from the University of Wales School of Medicine reported that sentinel node (SLN) biopsy accurately predicted axillary lymph node status in five male study patients with breast cancer. ...

Tamoxifen metabolite R-isomer forms more DNA adducts in liver cells.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- A tamoxifen metabolite R-isomer forms more DNA adducts in liver cells. "The antiestrogenic drug tamoxifen forms DNA adducts in rat liver through two genotoxic metabolites, a-hydroxytamoxifen and...

Slow release rate optimal for pegylated liposomal doxorubicin.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- Slow release rates produce optimal results with pegylated liposomal doxorubicin. In a recent study from Canada, the "pharmacokinetics (PK), biodistribution (BD), and therapeutic activity of...

Approval received to market Lyrica in Europe.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- Pfizer Inc said that it has received approval from the European Commission to market Lyrica (pregabalin) in all European Union member states for the treatment of peripheral neuropathic pain and as an...

Licensing agreement forged for antiphospholipid therapy technology.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- Peregrine Pharmaceuticals (NASDAQ:PPHM) announced that it has completed a worldwide exclusive licensing agreement for intellectual property related to anti- phosphatidylserine (anti-PS) antibodies. ...

M.D. Anderson named U.S.'s top cancer hospital.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- For the third consecutive year and fourth time in 5 years, The University of Texas M.D. Anderson Cancer Center is ranked the nation's top cancer hospital in U.S. News & World Report's "America's Best...

Early stage cancers could be predicted with accuracy by confocal laser endoscopy.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- The significance of cancer diagnosis trial results from the new flexible endo-microscope, jointly developed by Optiscan and Pentax, has been recognized by the prestigious international medical journal,...

Oncological impact of gene expression profiling reviewed.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- The oncological impact of gene expression profiling has been reviewed. "Genomics has enabled the examination of the totality of disease at the transcriptome level," scientists in the United States...

Molecular markers useful to detect various stages of non-small-cell lung cancer.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- Molecular markers are useful for detecting various stages of non-small-cell lung cancer. According to published research from Russia, "Studies performed in the recent decade in the Laboratory of the...

Biopharmaceutical company announces promotion agreement for Kadian.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- MGI Pharma, Inc., (MOGN) has entered into a 3-year agreement with Alpharma, Inc., to promote Alpharma's sustained release morphine sulfate product, Kadian. Under the terms of this promotion...

Maine gets high marks in American Cancer Society report.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- Maine was given the nation's top ranking in the ongoing fight against cancer in a report released by the American Cancer Society. The report, titled "How Do You Measure Up?," grades states on five...

New prostate cancer guidelines validate PSA and free PSA screening tests.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- New guidelines from the independent National Comprehensive Cancer Network (NCCN) strongly support the prostate specific antigen (PSA) and percent-free PSA blood tests to aid in the detection and...

Catalytic antioxidant inhibits tumor regrowth following radiation therapy.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- Incara Pharmaceuticals Corporation (ICRA) has announced further data that demonstrate that the administration of a compound, AEOL 10113, from the company's class of proprietary catalytic antioxidants...

DNABarrier cancer treatment licensed to Chinese biotechnology corporation.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- Mologen announced licensing of its dSLIM-based DNABarrier II to the Chinese biotechnology corporation Starvax Inc. of Beijing, PR China. DNABarrier II is one of three applications currently under...

Effects of P-glycoprotein inhibitors on paclitaxel uptake clarified.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- The interaction between the anticancer drug paclitaxel and P-glycoprotein inhibitors has been elucidated. "P-glycoprotein inhibitors can increase the oral bioavailability of paclitaxel,"...

Mechanics of girolline antitumor activity elucidated.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- The mechanisms underlying the anti-cancer activity of girolline have been elucidated. "Girolline, an antitumor compound isolated from a sponge, has been reported to inhibit the termination step of...

Nanomedicine global developments and growth opportunities explored.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- The adoption of nanotechnology-based applications by large therapeutic and diagnostic companies is accelerating the development of nanomedicine. The prospect of site-specific therapeutic action and...

National Cancer Institute grant received to develop multiplex cell assay.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- PharmaSeq announced the receipt of a Phase I SBIR grant from the U.S. National Cancer Institute, a branch of U.S. National Institutes of Health (NIH). The main goal of the research is to develop a...

Patent issued for method to predict effectiveness of chemotherapy.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- U.S. Patent and Trademark Office granted patent gene methylation technology for the prediction of clinical response to certain types of chemotherapeutic treatment of cancer patients. The treatment...

Pharmaceutical company applies for European agency approval of oral cancer drug.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- SuperGen, Inc. (SUPG) has submitted a marketing authorization application (MAA) seeking approval of Orathecin (rubitecan) capsules to the European Agency for the Evaluation of Medicinal Products (EMEA)....

Potential of TOR pathway as cancer therapy target reviewed.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- The potential of the TOR pathway as a target of cancer therapy has been reviewed. "Rapamycin, a macrocyclic lactone, is a highly specific inhibitor of the serine/threonine protein kinase target of...

Alloantigen presentation linked to CTL antigen response.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- The duration of alloantigen presentation and avidity of T cell antigen recognition correlate with immunodominance of CTL response to minor histocompatibility antigens. "CD8 T lymphocytes (CTL)...

Antennapedia transduction sequence promotes antitumor immunity.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- The Antennapedia transduction sequence promotes antitumor immunity to epicutaneously administered CTL epitopes. According to published research from Canada, "The identification of tumor antigens...

Autologous lymphoma vaccines induce T cell responses against epitopes.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- Autologous lymphoma vaccines induce human T cell responses against multiple, unique epitopes. "The clonotypic surface Ig receptor expressed by malignant B cells, idiotype, is a tumor-specific...

DNA fusion gene vaccines against cancer reviewed.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- Investigators review DNA fusion gene vaccines against cancer in a recent issue of Immunological Reviews. "Vaccination against target antigens expressed by cancer cells has now become a realistic...

NY-ESO-1-related HLA A2-restricted epitopes characterized.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- Researchers have determined the functional and structural characteristics of NY-ESO-1-related HLA A2-restricted epitopes. According to a study from Australia, "NY-ESO-1, a commonly expressed tumor...

Reduced L-selectin expression identifies tumor-specific type 1 T cells.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- Reduced L-selectin (CD62L[superscript]Low) expression identifies tumor-specific type 1 T cells from lymph nodes draining an autologous tumor cell vaccine. "Reduced expression of CD62L can identify...

SSX-2 epitope presented by dendritic cells to CD4+ T cells identified.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- Scientists have identified an SSX-2 epitope presented by dendritic cells to circulating autologous CD4+ T cells. According to recent research from the United States, "Accumulating evidence supports...

TCR DNA vaccine induces humoral response for lymphoma beta chain.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- A TCR DNA vaccine induced a humoral immunoreaction for the beta chain of T cell lymphoma. According to published research from China, "We exploited the humoral immunoreaction of mice induced by TCR...

Transfection of tumor antigens generates cytotoxic T lymphocytes.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- Transfection of RNA encoding tumor antigens following maturation of dendritic cells leads to prolonged presentation of antigen and the generation of high-affinity tumor-reactive cytotoxic T lymphocytes....

Mechanism of benzene-induced leukemia elucidated.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- The mechanism of benzene-induced leukemia has been elucidated. According to published research from the United States, "Acute myeloid leukemia and chronic lymphocytic leukemia are associated with...

Plutonium cancer risk questioned.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- Plutonium may be many times more dangerous than previously thought. The cancer risk from exposure inside the body could be 10 times higher than is allowed for in calculating international safety limits....

VEGF is a mediator of PCB 104-induced breast cancer cell invasion.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- VEGF is a mediator of PCB 104-induced breast cancer cell invasion. According to published research from the United States, "polychlorinated biphenyl (PCB) congeners, a group of worldwide,...

Role of ghrelin in catabolism reviewed.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- Researchers review the role of ghrelin in catabolism in a recent issue of the Journal of Endocrinological Investigation. According to a study from the Netherlands, "Catabolism is a metabolic...

Store-operated calcium ion entry regulates vascular smooth muscle gene activity.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- Store-operated calcium ion entry regulates vascular smooth muscle gene activity. "Ca2+-regulated gene transcription is a critical component of arterial responses to injury, hypertension, and...

Ectopic cyclin D1 expression blocks STI571-induced erythroid differentiation.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- Ectopic cyclin D1 expression blocks STI571-induced erythroid differentiation. According to published research from Japan, "Bcr-Abl tyrosine kinase inhibitor induces apoptosis and erythroid...

Nucleotide sequencing-based genotyping used to assess HPV disease link in Japan.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- Researchers in Japan have conducted the first large, case-control study using nucleotide sequencing-based genotyping of cervical cancer risk associated with human papillomavirus (HPV). According to...

U.K. screening program saves 5,000 lives annually.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- The success of Britain's national screening program for cervical cancer, introduced in 1988, was highlighted in an epidemiologic study in the July 17, 2004, issue of the Lancet. Authors of the...

Women tend to interpret cervical smear test results correctly.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- Answers women gave on a questionnaire about cervical cancer results show most interpreted the results correctly. "Screening for cervical cancer using the Papanicolaou smear test has been available...

MAX2 reproducibly estimates average per patient risk for chemotherapy toxicity.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- MAX2 reproducibly estimates average per patient risk for chemotherapy toxicity. According to recent research published in the European Journal of Cancer, "Cancer patients, especially the elderly,...

siRNA against NF-kappaB p65 subunit enhances sensitivity to chemotherapeutics.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- siRNA directed against the NF-kappaB p65 subunit enhances sensitivity to chemotherapeutics. "In preclinical tumor models, inhibition of nuclear factor-kappaB (NF-kappaB) has been associated with...

Alemtuzumab effective therapy for CLL with p53 mutations and deletions.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- Alemtuzumab is an effective therapy for chronic lymphocytic leukemia with p53 mutations and deletions. "The presence of p53 mutation or deletion predicts for poor response to conventional therapy...

PI3 kinase promotes CLL cell survival by preventing caspase 8 activation.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- PI3 kinase promotes survival of chronic lymphocytic leukemia (CLL) B cells by preventing caspase-8 activation. According to scientists in Chicago, "[s]tudies to investigate signal transduction...

IL-11 may improve thrombocytopenia associated with imatinib therapy in CML.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- IL-11 may improve thrombocytopenia associated with imatinib therapy in chronic myelogenous leukemia. According to published research from the United States, "During therapy with imatinib (Gleevec),...

Agreement signed for Kadian in cancer pain.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- Alpharma, Inc., (ALO) announced that it has entered into a 3-year agreement with MGI Pharma, Inc., an oncology focused biopharmaceutical company, for the promotion of Alpharma's Kadian product, a...

Intracellular thiols, calcium critical in parthenolide-induced apoptosis.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- Researchers from the National University of Singapore reported that intracellular thiols and calcium played critical roles in parthenolide-induced apoptosis in human colorectal cancer cells. ...

Sequential proteome alterations during genesis and progression of colon cancer.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- Researchers describe the sequential proteome alterations during genesis and progression of colon cancer in a recent issue of Cellular and Molecular Life Sciences. "Changes in the proteome of colon...

Herbs and spices have antimicrobial and chemopreventive properties.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- Herbs and spices have antimicrobial and chemopreventive properties. "Herbs and spices have been used for generations by humans as food and to treat ailments. Scientific evidence is accumulating that...

Real-time qPCR more sensitive than COBAS Amplicor for CMV DNA detection.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- A real-time quantitative PCR assay is more sensitive than the COBAS Amplicor assay for cytomegalovirus (CMV) DNA detection. According to a study from Sweden, "A duplex quantitative real-time PCR...

53BP1 required for class switch recombination.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- 53BP1 is required for class switch recombination "53BPI participates early in the DNA damage response and is involved in cell cycle checkpoint control. Moreover, the phenotype of mice and cells...

Balanced-PCR facilitates genomic DNA analysis.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- A "balanced" polymerase chain reaction (PCR) assay facilitates analysis of mildly degraded genomic DNA. "Analysis of genomic DNA derived from cells and fresh or fixed tissues often requires whole...

Discordant data from microarray platforms make drug research challenging.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- Discordant data from microarray platforms make drug research challenging. "Many commercial and custom-made microarray formats are routinely used for large-scale gene expression surveys. Here, we...

Alliance to deliver MRI CAD for breast cancer.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- Confirma, a developer of computer-aided-detection (CAD) for breast magnetic resonance imaging (MRI), and GE Healthcare announced they have signed a strategic alliance to bring MRI technologies for...

Methylated DNA collected by tampons detects endometrial cancer.
August 3, 2004... 2004 AUG 3 - (NewsRx.com & NewsRx.net) -- Methylated DNA collected by tampons detects endometrial cancer. According to recent research published in the journal Cancer Epidemiology Biomarkers & Prevention, "This proof of principle study...