Cancer Weekly articles from August 2003

Cancer Weekly archives from August 2003

Researchers identify secondary pathway for survival of cancer cells.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- Researchers at the Abramson Family Cancer Research Institute at the University of Pennsylvania have determined that a key enzyme, Pim-2, is responsible for the survival of cancer cells. The...

Scientists test new method to attack cancer.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- Scientists have used a technique called RNA interference to impair cancer cells' ability to produce a key enzyme called telomerase. The enzyme, present in most major types of cancer cells, gives...

Scientists find antitumor compounds in magnolia cones.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- The beloved southern magnolia, state flower of Louisiana and Mississippi, could provide more to cancer patients than shade and pretty flowers. A team of scientists at Emory University School of Medicine...

Sequential chemotherapy is effective for newly diagnosed de novo AML.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- Sequential chemotherapy is effective for newly diagnosed de novo AML. "EMA, consisting of etoposide, mitoxantrone, and cytarabine, is a timed-sequential chemotherapy (TSC) regimen and an efficacious...

Tumor-associated gangliosides modulate biological behaviors in tumors.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- Tumor-associated gangliosides modulate biological behaviors in tumors. According to a study from France, "neuroectodermic tumors can mostly be characterized by the presence of tumor-associated...

PD-ECGF causes head and neck cancers to cycle through growth phases quickly.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- PD-ECGF causes head and neck cancers to cycle through growth phases quickly. "Platelet-derived endothelial cell growth factor (PD-ECGF) was isolated as an endothelial mitogen from platelets and...

Treatment of differentiation arrest in pre-B-cell stage with SLP-65 is curative.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- SLP-65 given at the pre-B-cell stage doesn't allow arrest of differentiation or acute lymphoblastic leukemia type disease in a mouse model. According to a study from Germany, "Acute lymphoblastic...

Immunotherapy effective for relapsed stem cell transplant recipients.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- Immunotherapy can be effective for acute myeloid leukemia (AML) patients who relapse after stem cell allografting. Scientists in Austria described the case of a 35-year-old female AML patient "who...

Pigment epithelium-derived factor polices prostate and pancreatic tissues.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- Pigment epithelium-derived factor polices prostate and pancreatic tissues. According to a study from the United States, "angiogenesis sustains tumor growth and metastasis, and recent studies...

Hot spots in Tcf4 for the interaction with beta-catenin studied.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- Hot spots in Tcf4 for the interaction with beta-catenin studied. According to recent research published in the Journal of Biological Chemistry, "The interaction of beta-catenin with T-cell factor...

Mitochondrial heat shock protein may be one determinant of drug sensitivity.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- Mitochondrial heat shock protein may be one determinant of drug sensitivity. According to recent research published in the journal Leukemia Research, "Since DNA-dependent protein kinase (DNA-PK) has...

Oral DJ-927 has superior efficacy over i.v. paclitaxel or docetaxel.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- Oral DJ-927 has superior efficacy over i.v. paclitaxel or docetaxel. "DJ-927 is a novel taxane, which was selected for high solubility, non-neurotoxicity, oral bioavailability, and potent antitumor...

Oral glutamine did not protect against cisplatin-induced nephrotoxicity in rats.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- Oral glutamine did not protect against cisplatin-induced nephrotoxicity in rats. "The antioxidant activity of the amino acid glutamine was investigated to obtain protection against peroxidative...

The magnitude of hedgehog signaling activity defines skin tumor phenotype.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- The magnitude of hedgehog signaling activity defines skin tumor phenotype. According to a study from the United States, "Gain-of-function mutations in SMO have been implicated in constitutive...

A small fraction of giant cells potentially clonogenic.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- A small fraction of giant cells might be potentially clonogenic. "This study was designed to examine the viability and proliferation of uninucleated and multinucleated giant cells formed after 6 Gy...

One of 3 BLM helicase complexes, BRAFT, contains 5 Fanconi anemia proteins.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- One of the three Bloom syndrome BLM helicase complexes, BRAFT, contains 5 of the Fanconi anemia proteins. "Bloom syndrome (BS) is a genetic disorder associated with dwarfism, immunodeficiency,...

Phase II clinical trial of talampanel begins.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- IVAX Corp. (IVX) has initiated a phase II trial of talampanel to treat patients with brain cancer at the National Cancer Institute in Bethesda, Maryland. Dr. Howard Fine, chief of the neuro-oncology...

BRCA1 and BRCA2 mutations may contribute to early-onset breast cancer in Germany.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- BRCA1 and BRCA2 mutations may contribute to early-onset breast cancer in Germany. "This study was undertaken to investigate the prevalence of BRCA1 and BRCA2 germline mutations in 91 German patients...

Breast cancer worry and risk were determinants of prophylactic mastectomy.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- Breast cancer worry and risk were determinants of prophylactic mastectomy. "Scientific reports suggest that women at risk for familial breast cancer may benefit from prophylactic mastectomy,"...

Experts in U.K. want entry age for mammographic screening lowered to 47.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- Two leading U.K. cancer experts are calling for the entry age for mammographic screening for breast cancer to be reduced from 50 to 47 years for women in Britain. Their rationale is detailed in a...

High fat intake associated with increased risk.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- A large, prospective study of premenopausal women suggests that high intake of animal fat, especially from red meat and dairy products, is associated with an increase in risk of breast cancer. ...

Human breast cancer resistance protein may play a role in sterol transport.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- Human breast cancer resistance protein may play a role in sterol transport. "The human breast cancer resistance protein (BCRP, also know as ABCG2, MXR, or ABCP) is one of the more recently...

Ibuprofen, aspirin may reduce woman's risk.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- New research suggests that regular ibuprofen use may cut a woman's risk of developing breast cancer in half. Findings reported July 13, 2003, at the annual meeting of the American Association of...

Multiple suppressor genes may exist on the short arm of chromosome 8.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- Multiple suppressor genes may exist on the short arm of chromosome 8. According to a study from Australia, "Loss of heterozygosity (LOH) of the short arm of chromosome 8 occurs frequently in breast...

Research methods could mask association with high fat intake.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- Imprecise methods of assessing dietary intake could be potentially obscuring a link between increased fat intake and breast cancer, suggest authors of a research letter in the July 18, 2003, issue of...

Risk higher for young women with Hodgkin disease treated with radiation.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- Young women with Hodgkin disease (HD) treated with chest radiation alone have an increased risk for breast cancer, according to a study in the July 23/30, 2003, issue of the Journal of the American...

Study seeks women with recurring disease to test new antibody.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- The University of California, Los Angeles, Jonsson Cancer Center is testing an experimental immune system-boosting antibody that could one day help women who have not responded to conventional...

Study suggests PET not yet ready for disease staging.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- Despite its promise as a noninvasive method for diagnosing cancers, positron emission tomography (PET) is not sensitive enough for evaluating lymph node status in patients with breast cancer and should...

Swenerton score useful for selecting high-dose chemotherapy and stem cell transplant candidates.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- The Swenerton score is useful for selecting breast cancer patients likely to realize the most benefit from intensive chemotherapy and stem cell transplantation. Researchers in the United States...

There may be a functional relationship between breast adenocarcinoma and COX-2.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Scientists believe there may be a functional relationship between the enzyme cyclooxygenase-2 (COX-2) and the angiogenesis, or new vessel growth, of human...

Women should not ingest excessive food additives with estrogenic activity.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- Women should not ingest excessive food additives with estrogenic activity. According to a study from Japan, "Estrogenic activities of more than 90 chemicals including food additives, foodstuffs of...

Haplotype II is over-represented among chromosomes harboring mutations in BRCA1.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- Haplotype II is over-represented among chromosomes harboring mutations in BRCA1. According to a study from Spain, "The BRCA1 gene is included in a 200-400 kb region that is subjected to a...

Bronchioloalveolar carcinoma improved by tyrosine kinase inhibitor ZD1839.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- Bronchioloalveolar carcinoma can be improved by tyrosine kinase inhibitor ZD1839. "Bronchioloalveolar carcinoma (BAC), a form of pulmonary adenocarcinoma, presents unique clinical features, such as...

Uroplakin II derived primers detect the micrometastasis of several tumor types.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- Uroplakin II derived primers detect the micrometastasis of several tumor types. "The presence of circulatory metastasis is one of the most significant factors for poor-prognosis in patients with...

Researchers assess cancer mortality risk of workers at the Mayak nuclear complex.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- Researchers assess cancer mortality risk of workers at the Mayak nuclear complex. "At present, direct data on risk from protracted or fractionated radiation exposure at low dose rates have been...

Study suggests PEG-based laxatives may prevent colorectal cancer.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- A new research study suggests that the use of laxatives containing polyethylene glycol (PEG) may reduce the risk of colorectal tumors by 50%. The study was led by Denis E. Corpet, PhD, professor,...

Antisense to vigilin decreases protein synthesis in eukaryotes.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- Antisense to vigilin decreases protein synthesis in eukaryotes. "Vigilin, a member of the KH protein family, is exceptional among these proteins as it contains 14 KH domains in consecutive order....

17-AAG shows synergistic anticancer activity with leading chemotherapeutic agent.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- Kosan Biosciences, Inc., (KOSN) presented results of a preclinical study of 17-allylamino-17-demethoxygeldanamycin (17-AAG), at the 94th annual meeting of the American Association for Cancer Research...

Array BioPharma enters drug discovery collaboration focused on cancer.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- GenPath Pharmaceuticals, Inc., and Array BioPharma, Inc., (ARRY) announced a drug discovery collaboration agreement to identify small molecule drugs that target a novel tumor maintenance gene discovered...

Clinical development of TRAIL Receptor-2 antibody begins.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- Human Genome Sciences, Inc., (HGSI) announced it has received a clinical trial exemption (CTX) from the United Kingdom's Medicines and Healthcare products Regulatory Agency, allowing the company to...

Data presented on GEM231, second-generation antisense compound.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- Hybridon, Inc., (HYBN) announced the presentation of data from the phase I clinical trial of GEM231, the company's second-generation antisense compound for treating solid tumor cancers. The...

Data presented on new class of anticancer compounds.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- Avanir Pharmaceuticals (AVN) said its experimental compound AVP-893 showed selective growth inhibition against a variety of cancer cell lines in preclinical testing and early compound screening...

European, Swiss MAAs filed for Erbitux (cetuximab).
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- Merck, KgaA, (MRK) announced it filed marketing authorization applications (MAA) with the European Agency for the Evaluation of Medicinal Products (EMEA) and with Swissmedic for Erbitux (cetuximab) for...

IDM exercises option to license epitopes.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- IDM (Immuno-Designed Molecules), a European biopharmaceutical company in the field of cellular immunotherapy, announced it has exercised its option, under an evaluation and license option agreement, to...

LPAAT-beta provides cofactor for activation of two cancer cell survival pathways.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- In a symposium on cell signaling in cancer during the 94th annual meeting of the American Association for Cancer Research (AACR), scientists from Cell Therapeutics, Inc., (CTI) (CTIC) presented data on...

NCI awards grant for therapies targeting connective tissue growth factor.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- FibroGen, Inc., announced that the company has received a phase I small business innovation research (SBIR) grant from the National Cancer Institute (NCI), part of the National Institutes of Health...

New antifolate demonstrates efficacy in non-small cell lung cancer patients.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- Allos Therapeutics, Inc., (ALTH) announced the publication of results of a clinical study conducted by researchers at Memorial Sloan-Kettering Cancer Center (MSKCC). Their findings indicate that...

Phase II trial with Velcade begins in patients with mantle cell lymphoma.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- Millennium Pharmaceuticals, Inc., (MLNM) announced the initiation of a multicenter phase II clinical trial of Velcade in patients with relapsed or refractory mantle cell lymphoma. The single-arm,...

Regulation of tumor cell-derived vascular spaces is an anticancer strategy.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- Regulation of tumor cell-derived vascular spaces is an anticancer strategy. "Here we report that B16F10 murine melanoma cells mimic endothelial cell behavior and the angiogenic process in vitro and...

Thalidomide analogs have emerged as potentially new cancer treatments.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- Thalidomide analogs have emerged as potentially new cancer treatments. "Recently, it has been demonstrated that a number of novel thalidomide analogs possess anti-cancer properties due to their T...

Expression of tumor antigens in acute leukemias investigated.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- Expression of serologically identified tumor antigens in acute leukemias has been investigated. According to published research from Germany, "Cancer/testis antigens (CTA) are an expanding family...

HLA-A2 peptides are targets of HLA-A2-restricted cytotoxic T cells.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- Naturally occurring peptides associated with HLA-A2 in ovarian cancer cell lines were identified by mass spectrometry and determined to be targets of HLA-A2-restricted cytotoxic T cells. According...

Lentiviral vaccine targets dendritic cells and induces CD8+ T cell responses.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- In vivo administration of a lentiviral vaccine targets dendritic cells and induces efficient CD8+ T cell responses. "The present study evaluates the potential of third-generation lentivirus vectors...

Naked plasmid DNA injection into solid tumors of mice characterized.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- A team of researchers in Japan has characterized the disposition and gene expression in solid tumors and skeletal muscle after direct injection of naked plasmid DNA in mice. "Previous studies have...

Tumor escape strategies reviewed.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- The methods by which tumors evade detection and elimination by the immune system have been outlined in a recent issue of the European Journal of Immunogenetics. According to recent research from...

Scientist uses powerful weapons to track birth of killers.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- University of Rhode Island Assistant Professor Roberta S. King is on the hunt. Her game, however, is so small and insidious that she needs very powerful, expensive equipment to track and monitor it. ...

Study supports link between cadmium and cancer.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- The heavy metal cadmium, widely used in batteries and alloys, can affect rats in ways that mimic the female hormone estrogen, a new study has found. Researchers said the study suggests the metal may...

Researchers give prophylactic options in patients with 5-FU cardiotoxicity.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- Researchers give prophylactic options in patients with 5-FU cardiotoxicity. "At present, the various mechanisms involved in 5-fluorouracil (5-FU)-correlated cardiotoxicity remain to be elucidated...

Anticancer molecules work together.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- Two molecules known for their anticancer actions may be linked, according to a report. The discovery may help explain the beneficial effects of type I interferon (IFN-alpha/beta) against cervical and...

Researchers locate tumor-suppressor gene in fruit flies.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- UT Southwestern Medical Center at Dallas researchers have discovered a tumor-suppressor gene that, in fruit flies, simultaneously restricts cell proliferation and promotes cell death, a process that may...

HPV testing is valuable in detecting or excluding cervical cancer.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- HPV testing is valuable in detecting or excluding cervical cancer. "In a prospective cohort study, 8466 women attending routine cervical cancer screening were recruited. Colposcopy was performed on...

HPV-16 recurrence is associated with differing T cell response to L1 and E7.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- Specific T cell responses to HPV-16 proteins L1 and E7 are associated with different disease states and recurrence. "Human papillomavirus type 16 (HPV-16) L1 and E7 specific T cell responses were...

Study suggests HPV16 can skirt the immune system.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- In a large study of HIV positive women, human papillomavirus 16 (HPV16), the virus responsible for approximately half of all cervical cancers, appeared to be better at dodging the immune system than...

Micronucleus assay may correlate with normal tissue damage from radiotherapy.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- Micronucleus assay may correlate with normal tissue damage from radiotherapy. "In an effort to find a test to predict the response of normal tissue to radiotherapy, the lymphocyte micronucleus assay...

Some HOX genes may be involved in transformation of normal cervical cells.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- Some HOX genes may be involved in transformation of normal cervical cells. According to published research from Taiwan, "An association between deregulation of homeobox (HOX) gene expression and...

Acute respiratory failure with diagnosis of monocytic leukemia has poor outcome.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- Acute respiratory failure can sometimes be caused by acute monocytic leukemia; outcome worsens after chemotherapy. According to a study from France, "Acute respiratory failure revealing acute...

B-CLL drug resistance may occur due to p53 mutation caused by chemotherapy.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- B-CLL drug resistance may occur following p53 mutation caused by prior DNA damaging chemotherapy. According to a study from Germany, "Inactivation of p53 has been shown to correlate with poor...

Thiotepa absorbed by polyurethane catheter causes falsely elevated plasma levels.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- Thiotepa absorbed by polyurethane catheter causes falsely elevated plasma levels. According to a study from Netherlands, "Central venous access catheters are commonly used in clinical oncology. ...

Period analysis gives more up-to-date survival rates than cohort analysis.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- Period analysis gives more up-to-date survival rates than cohort analysis. "Survival rates of children with cancer have strongly improved during the past decades, but much of this improvement has...

Shelf registration statement filed; data on blood cancer therapy released.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- Ariad Pharmaceuticals, Inc., (ARIA) announced that it has filed a shelf registration statement with the U.S. Securities and Exchange Commission (SEC) for the issuance of up to 7.5 million shares of...

Stem cell transplantation shortly after imantinib treatment may exacerbate skin toxicity.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- Stem cell transplantation may exacerbate skin toxicity associated with imatinib treatment. "Imatinib is a new promising therapeutic option for chronic myeloid leukemia (CML) patients, with efficacy...

Standards of expertise in good clinical practice should be established.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- Standards of expertise in good clinical practice should be established. "It is a widely held belief that the current system of oversight of clinical research, particularly the means of assessing...

XIAP antisense oligonucleotide selected for development.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- Aegera Therapeutics, Inc., and Hybridon, Inc., (HYBN.OB) have selected a XIAP antisense oligonucleotide, AEG35156/GEM640, as the development candidate. This drug candidate showed potent antitumor...

AGS3 controls an early event during macroautophagy in intestinal HT-29 cells.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- AGS3 controls an early event during macroautophagy in intestinal HT-29 cells. "AGS3 contains GoLoco or G-protein regulatory motifs in its COOH-terminal half that stabilize the GDP-bound conformation...

Integrin-linked kinase signalling is dysregulated early in human colon cancer.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- Integrin-linked kinase signalling is dysregulated early in human colon cancer. "The putative oncogene, integrin-linked kinase (ILK), is a protein serine/threonine kinase that has been reported to...

Interim study: Leukine facilitates shortened-schedule chemo regimen.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- Interim results from an open-label trial of Leukine (sargramostim) used in combination with an aggressive colon cancer chemotherapeutic regimen indicate administration of the yeast-derived,...

Study identifies which patients benefit from chemotherapy.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- A new Canadian-led study shows that a simple genetic test can determine if chemotherapy will be effective in treating a patient's colon cancer, the second leading cause of cancer deaths in North...

Couric's exam sparks colonoscopy craze.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- The rate of people who were screened for colon cancer jumped by more than 20% after Katie Couric showed her colonoscopy on the "Today" show, a new study found. Researchers documented what many...

Macrophage colony-stimulating factor can act as colorectal tumor marker.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- Hematopoietic growth factors (HGFs) - particularly macrophage colony-stimulating factor (M-CSF) - may be markers for colorectal malignancy. HGFs "are involved in the regulation of growth and spread...

Many people ignore warning signs.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- Even when they suspect they may have symptoms of colorectal cancer, many people delay seeing a doctor, often for weeks or not at all, according to a recent study. Such attitudes, said Jill...

NSAIDs may protect against colon, rectal, stomach, and ovarian cancer.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- NSAIDs may protect against colon, rectal, stomach, and ovarian cancer. According to a study from Denmark, "There is increasing evidence of an inverse association between use of nonsteroidal...

Novel compound improves impact of standard anticancer therapy.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- A new therapy for metastatic cancer is showing significant clinical activity, according to research presented at the 94th Annual Meeting of the American Association for Cancer Research. The study...

Older drug could have exciting new role in treatment.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- Researchers at Wake Forest University Baptist Medical Center are reporting how a 15-year-old drug could have a promising new role in the treatment of rectal cancer. The drug is oxaliplatin, and when...

VEGF-C is a controlling factor for cancer-related lymph system growth.
August 5, 2003... 2003 AUG 5 - (NewsRx.com & NewsRx.net) -- VEGF-C is a controlling factor for cancer-related lymph system growth. "Lymphagenesis in gastrointestinal tumors is not well described. To clarify its presence and regulation, we assessed the...