Cancer Weekly articles from April 2001

Cancer Weekly archives from April 2001

Inflammatory Cells Play Important Role In Fate Of Early-Stage Tumors.
April 3, 2001... 2001 APR 3 - (NewsRx.com & NewsRx.net) -- Findings of two University of California, San Francisco, studies dramatize what scientists have just begun to recognize: while so-called oncogenic cells drive the development of cancerous tumors,...

Adenomatous Polyposis Coli Gene And Chromosome Instability Linked In Inherited Disease.(colorectal cancer)
April 3, 2001... 2001 APR 3 - (NewsRx.com & NewsRx.net) -- Colon cancer is the second most common cancer in the U.S., with 150,000 new cases diagnosed this year alone. Attempts to treat colon cancer are hampered by our gaps in our understanding of its...

Inherited Variants Of Three Genes Affect Treatment Response And Outcome.(for breast and other cancers)
April 3, 2001... 2001 APR 3 - (NewsRx.com & NewsRx.net) -- In findings that support potential tailored therapy for patients with cancer and possibly other diseases, Duke University Medical Center researchers and colleagues report finding that inherited...

Human Trials Begin For Antisense Drug.(for tumor treatment)
April 3, 2001... 2001 APR 3 - (NewsRx.com & NewsRx.net) -- Lorus Therapeutics Inc. announced March 19, 2001, that the U.S. Food and Drug Administration (FDA) has approved the company's Investigational New Drug (IND) application to begin a Phase I clinical...

VEGF-D Induces Cancer Spread Via Lymphatic System.(vascular endothelial growth factor causes lymphangiogenesis)
April 3, 2001... 2001 APR 3 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, staff medical writer - An Australian study suggests vascular endothelial growth factor-D (VEGF-D)-induced metastasis is disseminated via the lymphatic system. The new study...

Thymidine Kinase Antigen Offers Reliable Diagnostic Aid.(for nasopharyngeal cancer)
April 3, 2001... 2001 APR 3 - (NewsRx.com & NewsRx.net) -- by N.R. Saltmarsh, staff medical writer - An Epstein-Barr virus (EBV) thymidine kinase antigen may offer a more reliable way to test for nasopharyngeal cancer than other EBV antigens currently...

Vitamins C And E Combination Fights Side Effects Of Radiation Treatment For Cancers In Pelvic Area.
April 3, 2001... 2001 APR 3 - (NewsRx.com & NewsRx.net) -- A study involving 20 individuals suffering from chronic radiation proctitis showed that a daily regimen of vitamins E and C substantially reduced or eliminated the symptoms of the illness. This...

Cytokine Gene Expression May Have Therapeutic Value.(for glioblastoma multiforme tumors)
April 3, 2001... 2001 APR 3 - (NewsRx.com & NewsRx.net) -- by Deborah W. Heinrich, staff medical writer - Researchers at the University of Alabama reported the discovery of novel cytokine gene expression in primary glioblastoma multiforme (GBM) tumors which...

Globo H Vaccine Shows Promise For High-Risk Patients.(with metastatic breast cancer)
April 3, 2001... 2001 APR 3 - (NewsRx.com & NewsRx.net) -- by N.R. Saltmarsh, staff medical writer - Vaccination with the carbohydrate antigen globo H generates immunoglobulin M (IgM) antibody binding to tumor cells in patients with metastatic breast...

VEGF-C Links Lymphatic System Growth and Cancer Spread In Females.(vascular endothelial growth factor-C causes lymphangiogenesis in breast cancer tumors)
April 3, 2001... 2001 APR 3 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, staff medical writer - The evidence is mounting that a growth factor responsible for new blood vessel development in tumors is also related to the development of lymphatic systems...

Midkine Promoter May Facilitate Therapy In Midkine-Overexpressing Tumors.
April 3, 2001... 2001 APR 3 - (NewsRx.com & NewsRx.net) -- by Deborah W. Heinrich, staff medical writer - Researchers in Japan preferentially expressed herpes simplex virus-thymadine kinase in human carcinoma cells, rendering them susceptible to...

Phase III Trial Investigates Angiogenesis Signaling Inhibitor.(as a possible treatment of colorectal cancer)
April 3, 2001... 2001 APR 3 - (NewsRx.com & NewsRx.net) -- Pharmacia Corporation (PHA) announced March 16, 2001, the launch of a multi-national Phase III clinical trial to evaluate the addition of semaxanib (SU5416), an investigational angiogenesis...

Tumor Angiogenesis Is Prognostic Indicator For Recurrence And Patient Survival.(of squamous cell cancer of the esophagus)
April 3, 2001... 2001 APR 3 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, staff medical writer - New vessel growth, or tumor angiogenesis, predicts patient outcome in squamous cell cancer of the esophagus, according to a study in the March 2001 edition...

Low-Dose Gemcitabine Sensitizes Cells to Radiation Treatment.(in head and neck cancer)
April 3, 2001... 2001 APR 3 - (NewsRx.com & NewsRx.net) -- by N.R. Saltmarsh, staff medical writer - Low doses of gemcitabine lessen the danger of toxicity and adequately sensitize tumor cells to radiation in patients with head and neck cancer, researchers...

HCV A Risk Factor For Cancer Recurrence After Curative Treatments.(hepatitis C is one of the primary causes of liver cancer recurrence)
April 3, 2001... 2001 APR 3 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, staff medical writer - A new report indicates hepatitis C virus is one of two primary causes for liver cancer recurrence after treatments with newer, less invasive cancer...

Quality Of Life Better After Supracricoid Partial Laryngectomy Than With Complete Removal.
April 3, 2001... 2001 APR 3 - (NewsRx.com & NewsRx.net) -- by Deborah W. Heinrich, staff medical writer - Researchers at University of Pennsilvania report that patients with laryngeal cancer experience a better quality of life when treatment preserves part...

Overexpressed Proline-Directed Protein Kinase F-A Inhibits Growth Of Cancerous Cells.(in leukemia)
April 3, 2001... 2001 APR 3 - (NewsRx.com & NewsRx.net) -- by Deborah W. Heinrich, staff medical writer - Researchers in Taiwan have found that inhibition of proline-directed protein kinase F-A expression inhibits leukemia cell growth. "Initial studies...

Stem Cells Can Reduce Intensified Chemotherapy Complications.
April 3, 2001... 2001 APR 3 - (NewsRx.com & NewsRx.net) -- by Michael Greer, staff medical writer - The side effects of aggressive chemotherapy for lung cancer can be reduced by supplementary treatment with blood progenitor cells, according to oncologists...

Nitric Oxide Synthase Mechanisms Promote Metastasis, Effusion In Mice.(melanoma-associated metastases)
April 3, 2001... 2001 APR 3 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, staff medical writer - By limiting type II nitric oxide synthase expression in mice, researchers have discovered the mechanisms by which melanoma-associated metastases and pleural...

Denditric Cell Vaccines Incorporating Myeloma Protein Deemed Feasible.(for multiple myeloma vaccine)
April 3, 2001... 2001 APR 3 - (NewsRx.com & NewsRx.net) -- by N.R. Saltmarsh, staff medical writer - All classes of myeloma protein may be useful for producing dendritic cell (DC) vaccines with potent anti-tumor effects, according to a study published in...

Researchers Clarify Associated Genetic Alterations.(in patients with nasopharyngeal cancer)
April 3, 2001... 2001 APR 3 - (NewsRx.com & NewsRx.net) -- by N.R. Saltmarsh, staff medical writer - Researchers working at the U.S. National Institutes of Health have identified several chromosomal abnormalities in patients with nasopharyngeal cancer...

Tumors And Lymphocytes Are Infected By Different Strains Of Epstein-Barr Virus.(nasopharyngeal carcinoma cells infected by several strains of Epstein-Barr Virus)
April 3, 2001... 2001 APR 3 - (NewsRx.com & NewsRx.net) -- by Deborah W. Heinrich, staff medical writer - Epstein-Barr virus strains infecting nasopharyngeal carcinoma cells differ from those found in lymphocytes from the same patient. The fact that...

Nitric Oxide Synthase A Potential Target For Therapeutic Intervention.(for patients with oral squamous cell cancer)
April 3, 2001... 2001 APR 3 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, staff medical writer - Tumor levels of the nitric oxide synthase enzyme may be useful for directed treatment strategies in patients with oral squamous cell carcinoma. This...

Tumor-Produced IL-6 Possible Vaccine Candidate For Immune-Compromised Patients.(interleukin 6 may be used to vaccinate immune-compromised patients against metastasis)
April 3, 2001... 2001 APR 3 - (NewsRx.com & NewsRx.net) -- by N.R. Saltmarsh, staff medical writer - A pancreatic cancer cell line producing interleukin 6 (IL-6) may one day be used to vaccinate immune-compromised patients against metastasis. T. Yano...

Five-Year Follow-Up Data Support Cryosurgery As Primary Treatment.(for prostate cancer)
April 3, 2001... 2001 APR 3 - (NewsRx.com & NewsRx.net) -- Endocare, Inc. (ENDO), a developer of temperature-based treatments for prostate cancer and prostate obstruction, reported March 20, 2001, that new five-year follow-up data showed that cryoablation...

Drug Reverses DNA Damage Caused By Sunlight.(T4N5 liposome lotion for treatment of Xeroderma Pigmentosum)
April 3, 2001... 2001 APR 3 - (NewsRx.com & NewsRx.net) -- A topical lotion, applied once a day, uses liposomes to deliver DNA repair enzymes into the skin that reverse the DNA damage caused by sunlight. Daniel B. Yarosh, PhD, AGI Dermatics, Inc,...

Growth Factor Stimulates Carcinogenesis.(endothelial cell growth factor, fibroblast growth factor may stimulate salivary gland carcinogenesis)
April 3, 2001... 2001 APR 3 - (NewsRx.com & NewsRx.net) -- by Deborah W. Heinrich, staff medical writer - Researchers at the University of Tokushima have identified a growth factor that induces reproduction of submandibuliar gland cancer cells in mice. ...

Transcriptional Repressor Of Transforming Growth Factor-B Identified.(as a contributor to tumorigenicity of breast and colon cancer cell lines)
April 3, 2001... 2001 APR 3 - (NewsRx.com & NewsRx.net) -- by Deborah W. Heinrich, staff medical writer - Researchers at the University of Texas report that the nuclear factor Sp3 is a transcriptional repressor of transforming growth factor-B (TGF-B)...

Smaller Doses of Chemotherapy More Frequently May Attack Tumor Blood Supply.(Brief Article)
April 10, 2001... 2001 APR 10 - (NewsRx.com & NewsRx.net) -- Radiation oncologists at Thomas Jefferson University Hospital in Pennsylvania are giving chemotherapy more frequently than usual and in tinier doses, targeting the process by which a new blood...

Phase II Trial Finds Docetaxel-Cisplatin Combination Too Toxic.(Brief Article)
April 10, 2001... 2001 APR 10 - (NewsRx.com & NewsRx.net) -- by N.R. Saltmarsh, staff medical writer - Some patients are willing to accept toxic side effects in exchange for better outcomes, but an experimental chemotherapy combination offers only the...

Scientists Investigate How 'Knots' In DNA Affect Genes.(Brief Article)
April 10, 2001... 2001 APR 10 - (NewsRx.com & NewsRx.net) -- In their search for better ways to combat cancer, scientists are looking at knots in DNA as potential targets for new cancer therapeutics. These knots occur when DNA folds over upon itself,...

Limiting VEGF Reduces Tumor Resistance to Radiotherapy.(Brief Article)
April 10, 2001... 2001 APR 10 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, staff medical writer - Resistance to radiotherapy can be overcome in some tumors by treating them with vascular endothelial growth factor (VEGF) antagonists, researchers report....

Clonotypic Test Can Find Minimal Residual Disease.(Brief Article)
April 10, 2001... 2001 APR 10 - (NewsRx.com & NewsRx.net) -- by Michael Greer, staff medical writer - Researchers in New York have developed an effective test for finding residual disease in chronic lymphocytic leukemia (CLL) patients in remission. ...

Intensity-Modulated Radiation Therapy: Lower Radiation Doses, Improved Target Coverage.(Brief Article)
April 10, 2001... 2001 APR 10 - (NewsRx.com & NewsRx.net) -- by Deborah W. Heinrich, staff medical writer - Researchers from the Memorial Sloan Kettering Cancer Center in New York found that Intensity Modulated Radiation Therapy (IMRT) as a treatment for...

Vaccine Research Results Show Hope For Use Of Dendritic Cells.(Brief Article)
April 10, 2001... 2001 APR 10 - (NewsRx.com & NewsRx.net) -- Results from the first-ever study testing the use of dendritic cells in children may offer new hope for a cancer vaccine. The Phase I study results from research at the University of Michigan...

Growth Factor In Urine Predicts Survival In Hormone-Refractory Patients.(Brief Article)
April 10, 2001... 2001 APR 10 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, staff medical writer - Medical researchers report a key growth factor can predict survival in patients with hormone-refractory prostate cancer. The growth factor, vascular...

Thalidomide Sparks Hepatitis Onset In Leukemia Patient.(Brief Article)
April 10, 2001... 2001 APR 10 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, staff medical writer - Doctors in Canada say thalidomide is potentially toxic to the liver. Physicians in Toronto, Ontario, reported a case study in which a patient being...

Arthritis Drug Will Be Tested Against Cancerous Tumors.(Brief Article)
April 10, 2001... 2001 APR 10 - (NewsRx.com & NewsRx.net) -- Cancer researchers are poised to begin a study to determine if a commonly prescribed arthritis drug can shrink tumors. The trial is still before the scientific review committee at the...

Synthetic Enzyme Improves Efficacy Of Interleukin-2 Therapy.(Brief Article)
April 10, 2001... 2001 APR 10 - (NewsRx.com & NewsRx.net) -- Advanced skin and end-stage kidney cancer patients may have a better chance of survival with drugs developed from a new synthetic enzyme that significantly improves the effectiveness of existing...

Hydroxychloroquine Can Kill Malignant B Cells.(Brief Article)
April 10, 2001... 2001 APR 10 - (NewsRx.com & NewsRx.net) -- by Michael Greer, staff medical writer - Hydroxychloroquine, used to treat malaria and rheumatism, may also provide therapeutic benefit to B-chronic lymphocytic leukemia (B-CLL) patients, according...

Preclinical Data Presented On Growth-Factor Inhibitor.(Brief Article)
April 10, 2001... 2001 APR 10 - (NewsRx.com & NewsRx.net) -- ImClone Systems, Inc. (IMCL) announced preclinical findings from a study of the company's lead cancer therapeutic, IMC-C225, demonstrating its anti-tumor activity in combination with irinotecan in...

Rice Bran Extract Arrests Breast Cancer Tumor Cell Growth In Vitro.(Brief Article)
April 10, 2001... 2001 APR 10 - (NewsRx.com & NewsRx.net) -- A natural supplement used by thousands to stimulate the immune system can arrest tumor cell growth as well, according to a study reported March 25, 2001, at the 92nd Annual American Academy of...

Classification Of Radiation Damage To Teeth Can Lead To Early Treatment.(Brief Article)
April 10, 2001... 2001 APR 10 - (NewsRx.com & NewsRx.net) -- by N.R. Saltmarsh, staff medical writer - Radiation caries is an established clinical finding following treatment for head and neck cancer, but it lacks official classification according to...

Simultaneous Adenoviral Vector Infection Induces Tissue-Specific Gene Expression.(Brief Article)
April 10, 2001... 2001 APR 10 - (NewsRx.com & NewsRx.net) -- by Deborah W. Heinrich, staff medical writer - Researchers at Kanazawa University in Japan used the simultaneous infection of two recombinant adenoviral vectors to induce tissue-specific gene...

Angiogenesis Inhibitor Lengthens Median Survival Two-Fold.(Brief Article)
April 10, 2001... 2001 APR 10 - (NewsRx.com & NewsRx.net) -- AEterna Laboratories, Inc. (AEL, AELA) reported on March 26, 2001, clinical data from a Phase I/II clinical trial, demonstrating a statistically significant two-fold increase (p The median...

Aflatoxin Exposure Increases Disease Risk Among Population In Asia.(Brief Article)
April 10, 2001... 2001 APR 10 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, staff medical writer - New research indicates exposure to the liver toxin aflatoxin is high among some populations in Asia, suggesting a need to limit aflatoxin exposure to reduce...

Dual Procedures Increase Survival When Portal Vein Tumor Thrombus Is Present.(Brief Article)
April 10, 2001... 2001 APR 10 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, staff medical writer - Chemoembolization followed by hepatectomy may be the best approach for increasing survival in liver cancer patients with a portal vein tumor thrombus. ...

Survival Rates Low After Surgery For Hepatocellular Carcinoma Recurrence.(Brief Article)
April 10, 2001... 2001 APR 10 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, staff medical writer - Disease-free survival rate in patients treated for liver cancer recurrence is low, according to medical researchers at Japan's Nara Medical University. ...

Data Show Compound Inhibits Angiogenesis, Stimulates Apoptosis.(Brief Article)
April 10, 2001... 2001 APR 10 - (NewsRx.com & NewsRx.net) -- New preclinical research by scientists from Cell Pathways, Inc. (CLPA) and its collaborators further supports the ongoing clinical investigation of the company's lead investigational drug,...

Peptide-Based Linking Improves Retention Of Radioisotope In Tumors.(Brief Article)
April 10, 2001... 2001 APR 10 - (NewsRx.com & NewsRx.net) -- Immunomedics, Inc. (IMMU) announced an advance made by the company's scientists in the attachment of iodine-131 (I-131), a potent therapeutic isotope, to antibodies. The improved technique was...

Prodrugs Enhance Standard Chemotherapy In Clinical Trials.(Brief Article)
April 10, 2001... 2001 APR 10 - (NewsRx.com & NewsRx.net) -- Vion Pharmaceuticals, Inc. (VION) announced on March 25, 2001, results of trials with prodrugs of Triapine(R), its small molecule ribonucleotide reductase inhibitor (RRI), at the 92nd Annual...

Results Reported On Novel Vaccine Tested In Mice.(Brief Article)
April 10, 2001... 2001 APR 10 - (NewsRx.com & NewsRx.net) -- ImClone Systems Inc. (IMCL) announced March 26, 2001, positive preclinical findings on its novel recombinant hTRPx3 protein-based melanoma vaccine. The presentation was made at the 92nd Annual...

Encapsulated Vincristine To Be Tested In CHOP Therapy.(Brief Article)
April 10, 2001... 2001 APR 10 - (NewsRx.com & NewsRx.net) -- Inex Pharmaceuticals Corp. (INEX; IEX) announced on March 26, 2001, that a Phase II clinical trial has begun enrolling patients to evaluate its lead product Onco TCS as part of a first-line...

Pretreatment Apoptotic Scores Not Of Value For Post-Therapy Prognosis.(Brief Article)
April 10, 2001... 2001 APR 10 - (NewsRx.com & NewsRx.net) -- by Deborah W. Heinrich, staff medical writer - Researchers from Hokkaido University in Japan found no correlation between pretreatment apoptotic scores and a patient's prognosis after radical...

Hepatitis B Virus X Protein Mediates Toxin-Induced Liver Cancer.(Brief Article)
April 10, 2001... 2001 APR 10 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, staff medical writer - Experiments performed on double-transgenic mice indicate the hepatitis B virus (HBV) X protein acts as a cofactor for carcinogen-induced liver cancers by...

Low-Dose Thalidomide Effective As Salvage Therapy.(Brief Article)
April 17, 2001... 2001 APR 17 - (NewsRx.com & NewsRx.net) -- by Michael Greer, staff medical writer - Low doses of thalidomide can preserve its therapeutic effects for advanced multiple myeloma patients while reducing its toxicity, according to researchers...

Not Enough Data To Recommend Brachytherapy Over Standard Therapy - Yet.(Brief Article)
April 17, 2001... 2001 APR 17 - (NewsRx.com & NewsRx.net) -- A new study says there is insufficient evidence to recommend unconditionally the use of brachytherapy over current standard therapy for localized prostate cancer. Despite the absence of data...

Very Low Doses Of Potent New Drug Reduce Complications Of Bone Metastases In Some Cancers.(Brief Article)
April 17, 2001... 2001 APR 17 - (NewsRx.com & NewsRx.net) -- Researchers at Cedars-Sinai Medical Center, Los Angeles, California, report that very low doses of a potent new drug called zoledronic acid reduce the complications that arise from multiple...

Molecular Envelopes Help Medicines Penetrate Multidrug-Resistant Cancer Cells.(Brief Article)
April 17, 2001... 2001 APR 17 - (NewsRx.com & NewsRx.net) -- Researchers believe they have found a way to defeat the multidrug resistance of many cancer cells and to dramatically reduce some of the undesirable side effects of chemotherapy. Based on work...

Concurrent Radiation, Chemo Yields 30% Survival At Five Years.(Brief Article)
April 17, 2001... 2001 APR 17 - (NewsRx.com & NewsRx.net) -- by N.R. Saltmarsh, staff medical writer - Patients with locally advanced head and neck cancers who are deemed poor candidates for surgery can benefit from combination radiation and chemotherapy,...

Common Genetic Differences Affect Vulnerability To Childhood Disease.(Brief Article)
April 17, 2001... 2001 APR 17 - (NewsRx.com & NewsRx.net) -- By focusing on molecular differences that define distinct types of childhood leukemia, scientists have discovered that vulnerability to one type of the cancer or another depends on something as...

Gene Therapy Doubles Survival Time For Brain Cancer Patients.(Brief Article)
April 17, 2001... 2001 APR 17 - (NewsRx.com & NewsRx.net) -- Ark Therapeutics, Ltd., announced on April 4, 2002, positive results from a Phase I/IIa clinical trial investigating its new gene medicine treatment, EG009, for malignant glioma, an aggressive form...

Delayed Granulocyte Colony-Stimulating Factor Treatment Is Cost-Effective.(Brief Article)
April 17, 2001... 2001 APR 17 - (NewsRx.com & NewsRx.net) -- by Michael Greer, staff medical writer - Late initiation of granulocyte colony-stimulating factor (G-CSF) therapy after stem cell transplantation for cancer treatment can markedly reduce the cost...

Monoclonal Antibody Shows Anti-Angiogenic Activity.(Brief Article)
April 17, 2001... 2001 APR 17 - (NewsRx.com & NewsRx.net) -- Abgenix, Inc. (ABGX) announced preclinical study results showing that its investigational human monoclonal antibody, ABX-IL8, blocks angiogenesis and inhibits the growth of human melanoma tumors...

ACS Releases New Guidelines For Patients, Families.(Brief Article)
April 17, 2001... 2001 APR 17 - (NewsRx.com & NewsRx.net) -- For the first time ever, treatment guidelines used by oncology professionals to manage cancer pain have been translated into specific, reliable, and easy-to-understand language for patients and...

HPV 18 Strain Is Associated With Doubled Mortality Rate.(Brief Article)
April 17, 2001... 2001 APR 17 - (NewsRx.com & NewsRx.net) -- A strain of human papillomavirus called HPV 18, which is found in up to 30% of women with cervical cancer, appears to be associated with a mortality rate that is nearly double that of other...

Anti-Cancer Metastasis Compound Headed Into Five Clinical Trials.(Brief Article)
April 17, 2001... 2001 APR 17 - (NewsRx.com & NewsRx.net) -- GLYCODesign, Inc. (GD) is expanding its clinical program to validate the effectiveness of GD0039, its anti-cancer compound. The expansion includes five Phase II clinical trials for multiple cancer...

Over 400 Drugs In Pipeline for Cancer, PhRMA Survey Says.(Brief Article)
April 17, 2001... 2001 APR 17 - (NewsRx.com & NewsRx.net) -- Pharmaceutical researchers are developing 402 new weapons to target cancer, many of them cutting-edge medicines that will be alternatives to standard radiation and chemotherapy treatments that are...

Protein Inhibitor Targets Chronic Myeloid Leukemia And Gastrointestinal Stromal Tumors.(Brief Article)
April 17, 2001... 2001 APR 17 - (NewsRx.com & NewsRx.net) -- A compound developed to fight one form of leukemia at the molecular level also is working to combat a rare gastrointestinal cancer, report researchers in the April 5, 201, issue of the New England...

Vinorelbine Plus Cisplatin Effective For Recurrent Salivary Tumors.(Brief Article)
April 17, 2001... 2001 APR 17 - (NewsRx.com & NewsRx.net) -- by N.R. Saltmarsh, staff medical writer - A course of vinorelbine plus cisplatin is more effective than vinorelbine alone for treatment of recurrent salivary gland tumors, study data indicate. ...

Streptococcus anginosus Is Implicated In Carcinogenesis.(Brief Article)
April 17, 2001... 2001 APR 17 - (NewsRx.com & NewsRx.net) -- by Deborah W. Heinrich, staff medical writer - Researchers at the Miyagi Cancer Center in Japan report that Streptococcus anginosus infection is linked to development of squamous cell carcinoma....

Researchers Investigate Cytotoxic And Radiosensitizing Potential Of Docetaxel.(Brief Article)
April 17, 2001... 2001 APR 17 - (NewsRx.com & NewsRx.net) -- by Deborah W. Heinrich, staff medical writer - Researchers at the University of Gottingen in Germany tested the cytotoxic and radiosensitizing potential of the drug docetaxel on cell lines from...

Data Show Drug Triggers Anti-Angiogenesis, Apoptosis.(Brief Article)
April 17, 2001... 2001 APR 17 - (NewsRx.com & NewsRx.net) -- Introgen Therapeutics, Inc. (INGN) announced March 29, 2001, that its gene therapy product candidate INGN 241, Adenoviral-mda7, may offer potential benefits in the treatment of lung cancer. ...

Protein Identified That May Induce Drug Resistance In Cancer Cells.(Brief Article)
April 17, 2001... 2001 APR 17 - (NewsRx.com & NewsRx.net) -- University of Florida researchers have identified a protein that appears to play a key role in fortifying lung cancer cells against the powerful chemotherapy drugs designed to kill them. The...

Nonviral, Electroporation-Assisted Vaccine Produces 100% Tumor Rejection In Mice.(Brief Article)
April 17, 2001... 2001 APR 17 - (NewsRx.com & NewsRx.net) -- by N.R. Saltmarsh, staff medical writer - A plasmid-delivered vaccine consisting of two melanoma tumor antigens enabled mice to completely overcome tumor challenge and even improved survival time...

Tumor-Specific Expression of TNF Receptor Triggers Apoptosis.(Brief Article)
April 17, 2001... 2001 APR 17 - (NewsRx.com & NewsRx.net) -- by Deborah W. Heinrich, staff medical writer - Researchers at the University of Verona in Italy induced apoptosis in melanoma cell lines, using expression of the tumor necrosis factor (TNF)...

Study Finds Deletion In LMPI Gene Not A Predisposing Factor.(Brief Article)
April 17, 2001... 2001 APR 17 - (NewsRx.com & NewsRx.net) -- by N.R. Saltmarsh, staff medical writer - A gene deletion thought to indicate a predisposition for nasopharyngeal cancer (NPC) may not be as significant as originally believed. The LMPI gene,...

Alpha Folate Receptor Is Overexpressed In Tumor Cells.(Brief Article)
April 17, 2001... 2001 APR 17 - (NewsRx.com & NewsRx.net) -- by Deborah W. Heinrich, staff medical writer - A study at Harvard University and Brigham and Women's Hospital in Boston, Massachusetts, analyzed differential gene expression in malignant pleural...

Angiogenic Switch Causes Malignancy Progression In Murine Model.(Brief Article)
April 17, 2001... 2001 APR 17 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, staff medical writer -- U.S. researchers suggest, based on their study of mice, that progression of prostate cancer is linked to an angiogenic switch. Dissection of this...

Compound Causes Up To Five-Fold Decrease In Tumor Weight, Volume.(Brief Article)
April 17, 2001... 2001 APR 17 - (NewsRx.com & NewsRx.net) -- Collgard Biopharmaceuticals, Ltd., reports that low doses of its proprietary lead compound, Halofuginone, caused a four- to five-fold decrease in human tumor weight and volume in SCID mice when...

Reversing DNA Damage Caused By The Sun May Be Possible.(Brief Article)
April 17, 2001... 2001 APR 17 - (NewsRx.com & NewsRx.net) -- Scientists have synthesized an artificial enzyme they believe can repair sun-damaged DNA, the cause of many skin cancers. Although promising, they emphasize that much more research needs to be...

VEGF Staining In Thyrocytes Indicates Risk For Metastasis.(Brief Article)
April 17, 2001... 2001 APR 17 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, staff medical writer - Excess vascular endothelial growth factor (VEGF) staining in thyroid cancer cells is indicative of the risk for metastasis, according to a new study. ...

Leukocyte Depletion Not Linked To Colorectal Cancer Recurrence, Reduced Survival.(Brief Article)
April 17, 2001... 2001 APR 17 - (NewsRx.com & NewsRx.net) -- by Michael Greer, staff medical writer - Using leukocyte-depleted blood for colorectal cancer surgery transfusions has little effect on the associated risks, hematologists in The Netherlands...

Dendritic-Glioma Fusion Vaccine Gets Boost From Interleukin-12.(Brief Article)
April 24, 2001... 2001 APR 24 - (NewsRx.com & NewsRx.net) -- by N.R. Saltmarsh, staff medical writer - The addition of interleukin-12 (IL-12) to a vaccine of fused dendritic and glioma cells significantly improved survival time for mice with brain tumors,...