Cancer Weekly articles from April 2000

Cancer Weekly archives from April 2000

Cytokine Gene Therapy Uses Fibroblasts to Enhance Tumor Immunity.(Brief Article)(Statistical Data Included)
April 4, 2000... 2000 APR 4 - (NewsRx.com) -- Cytokine gene therapies can make use of fibroblasts and dendritic cells to enhance tumor immunity. "Recombinant interleukin (IL)-2 administration can mediate regression of solid tumors in patients with...

Gene Gun Generates Effector T Cells for Adoptive Therapy.(Brief Article)(Statistical Data Included)
April 4, 2000... 2000 APR 4 - (NewsRx.com) -- Using the gene gun for plasmid bombardment induces generation of effector T cells. "We utilized the gene gun to transfect subcutaneous D5 melanoma and MT-901 mammary carcinoma tumors in situ with a...

p21 Adenovirus Exhibits Growth Inhibitory Effect.(Brief Article)(Statistical Data Included)
April 4, 2000... 2000 APR 4 - (NewsRx.com) -- p21 adenovirus has a growth inhibitory effect on human bladder cancer cells, researchers from the United States report. University of Texas researcher M.C. Hall and colleagues evaluated "whether p21...

Monoclonal UBC-ELISA Test and NMP22 ELISA Test Compared.(Brief Article)(Statistical Data Included)
April 4, 2000... 2000 APR 4 - (NewsRx.com) -- In a comparison study of diagnostic tests for urothelial cell carcinoma of the bladder, the monoclonal urinary bladder cancer (UBC)-ELISA test fared better than the nuclear matrix protein (NMP)22 ELISA test,...

IFN Gene Transfer Up-Regulates p53 in Melanoma Cells.(Brief Article)(Statistical Data Included)
April 4, 2000... 2000 APR 4 - (NewsRx.com) -- Type I consensus interferon (CIFN) gene transfer into human melanoma cells up-regulated p53 expression and enhanced cisplatin-induced apoptosis, according to a recent report. "In this study, we describe...

Older Patients May Benefit From Aggressive Radiation Therapy.(Brief Article)(Statistical Data Included)
April 4, 2000... 2000 APR 4 - (NewsRx.com) -- Preliminary research suggests that aggressive radiation therapy may be safe and effective in older cancer patients. "Review of the literature shows that selected patients who have good performance status...

Genetic Vaccination with Self Protein Eradicates Melanoma in a Murine Model.(Brief Article)(Statistical Data Included)
April 4, 2000... 2000 APR 4 - (NewsRx.com) -- Genetic vaccination with a self tyrosinase-related protein 2 caused melanoma eradication but not autoimmune aggression, researchers from Italy reported. "'Self' melanocyte differentiation antigens are...

Interleukin-2 Enhances Therapeutic Anticancer Vaccines.(Brief Article)(Statistical Data Included)
April 4, 2000... 2000 APR 4 - (NewsRx.com) -- Interleukin (IL)-2 can enhance the therapeutic efficacy of anticancer vaccines, suggested a study from the United States. "The purpose of our efforts is to trigger the immune destruction of established...

Atomic Structure of Cancer-Protecting Protein Determined.(Brief Article)(Statistical Data Included)
April 4, 2000... 2000 APR 4 - (NewsRx.com) -- Agouron Pharmaceuticals, Inc., La Jolla, California, announced that its scientists have solved the atomic structure of a protein that plays a critical role in cell cycle regulation. This protein,...

Pre-Targeted Therapy Uses Streptavidin-CC49 MAb and Y-90-DOTA-biotin.(Brief Article)(Statistical Data Included)
April 4, 2000... 2000 APR 4 - (NewsRx.com) -- Pre-targeted radioimmunotherapy of human colon cancer xenografts in athymic mice was achieved by using streptavidin-CC49 monoclonal antibody (MAb) and Y-90-DOTA-biotin. "Radioimmunotherapy of solid...

Immunohistochemical Staining Acceptable for Detecting Mutation.(Brief Article)(Statistical Data Included)
April 4, 2000... 2000 APR 4 - (NewsRx.com) -- Although gene sequencing remains the preferred method for detecting p53 tumor suppressor gene mutations common in hepatocellular carcinomas (HCCs), immunohistochemical staining is an acceptable alternative...

Dispersed Tumors Not Clonally Related.(Brief Article)(Statistical Data Included)
April 4, 2000... 2000 APR 4 - (NewsRx.com) -- Researchers have found evidence that metachronous head and neck squamous cell carcinomas (HNSCCs) located in different regions of the body are not clonally related. Whether multiple tumors (MTs) arise...

Genomic Overrepresentations of c-myc and Int-2 Observed.(Brief Article)(Statistical Data Included)
April 4, 2000... 2000 APR 4 - (NewsRx.com) -- Researchers have found overrepresentations of the (alpha)-satellites c-myc and Int-2 in nasopharyngeal carcinoma (NPC). Because the genetic basis of NPC, a commonly occurring tumor in southern China, is...

Homeobox Genes Associated with Aggressive Disease.(Brief Article)(Statistical Data Included)
April 4, 2000... 2000 APR 4 - (NewsRx.com) -- Researchers have found an association between the homeobox gene NKX3.1 and more aggressive types of prostate carcinoma. Research indicates that, in mouse prostates, NKX3.1 is tissue-specifically expressed...

Mitogenic Signaling is Heterogeneous.(Brief Article)(Statistical Data Included)
April 4, 2000... 2000 APR 4 - (NewsRx.com) -- In prostate cancer, mitogenic signaling is heterogeneous, and proliferation may be induced by androgens and growth factors through divergent signaling pathways. C.H. Guo and colleagues at Duke University,...

High-Dose Interleukin-2 Treatment Effective for Some Patients.(Brief Article)(Statistical Data Included)
April 4, 2000... 2000 APR 4 - (NewsRx.com) -- High-dose interleukin-2 treatment can add years to the lives of some patients with metastatic renal cell carcinoma, according to a study update. "Recombinant IL-2 600,000 or 720,000 IU/kg was administered...

Expression of Ki-67 Correlates with Clinical Prognostic Factors.(Brief Article)(Statistical Data Included)
April 4, 2000... 2000 APR 4 - (NewsRx.com) -- Expression of Ki-67 is not diagnostic, but does correlate with clinical prognostic factors in vulvar carcinoma patients, according to a recent report. "In vulvar carcinoma, the expression of Ki-67 has been...

p53-Containing Adenovirus for Treatment of Drug-Resistant Ovarian Cancer Evaluated.(Brief Article)(Statistical Data Included)
April 4, 2000... 2000 APR 4 - (NewsRx.com) -- Gene therapy targeting the p53 gene was evaluated in a Phase I study of patients with platinum- and paclitaxel-resistant epithelial ovarian cancer. "Adp53 is a replication deficient adenovirus containing...

Mutant Type-1 Herpes Simplex Virus Therapy Prolongs Survival in Mice.(Brief Article)(Statistical Data Included)
April 4, 2000... 2000 APR 4 - (NewsRx.com) -- Mutant type-1 herpes simplex virus (HSV) therapy prolonged survival in a murine intraperitoneal tumor model, reported researchers from the United States. "HSV-1716, a mutant replicating herpes simplex...

Phase IIB Trial Evaluates Adenovirus Therapy in Hepatobiliary Tumors.(Brief Article)(Statistical Data Included)
April 4, 2000... 2000 APR 4 - (NewsRx.com) -- Researchers from the United States have evaluated ONYX-015 therapy for hepatobiliary tumors in a Phase IIB trial. "ONYX-015 is a group C adenovirus with a deletion in the region coding for the E1B 55-kDa...

Radiofrequency Energy Cooks, Kills Cancerous Tumors.(Brief Article)(Statistical Data Included)
April 4, 2000... 2000 APR 4 - (NewsRx.com) -- Using radiofrequency (RF) energy to "cook" and kill cancerous tumors without affecting surrounding healthy tissue may provide an alternative to surgery for patients with kidney and other cancers, according to...

Fragile Histadine Triad Gene Expression Linked to Smoking-Related Cancer.(Brief Article)(Statistical Data Included)
April 4, 2000... 2000 APR 4 - (NewsRx.com) -- Loss or reduction of fragile histadine triad (FHIT) gene expression is found more frequently in cervical cancer of female smokers than in that of female nonsmokers, according to researchers. FHIT, a...

HPV-E5 Protein Targeted by Peptide Vaccine.(Brief Article)(Statistical Data Included)
April 4, 2000... 2000 APR 4 - (NewsRx.com) -- The E5 protein of the human papillomavirus (HPV) is a potential target for a novel prophylactic peptide-based vaccine for cervical cancer, researchers from the United States reported. "There are active...

Role in Protection from Carcinogens Evaluated.(Brief Article)(Statistical Data Included)
April 4, 2000... 2000 APR 4 - (NewsRx.com) -- Researchers have found direct evidence that DNA repair genes help suppress the development of cancer. It is widely believed that DNA repair protects organisms from developing cancer, but few direct in vivo...

Magnets Used to Direct Cancer-Killing Agents to Tumors.(Brief Article)(Statistical Data Included)
April 4, 2000... 2000 APR 4 - (NewsRx.com) -- Using rare earth magnets to draw chemotherapy-carrying magnetic particles into tumors holds promise in the battle against cancer, according to early research from a multicenter study presented at the 25th...

Enhanced Adenovirus Shows Increased Oncolysis in vivo.(Brief Article)(Statistical Data Included)
April 4, 2000... 2000 APR 4 - (NewsRx.com) -- A conditionally replicative adenovirus (CRAD) with enhanced infectivity was better able to induce tumor regression in mice with ovarian cancer than non-replicative viruses, according to a recent report. ...

New Polymer Inhibits Potentially Drug-Resistant Cell Lines.(Brief Article)(Statistical Data Included)
April 4, 2000... 2000 APR 4 - (NewsRx.com) -- A new polymer derived from an antibacterial drug has unexpectedly and dramatically inhibited the growth of ovarian cancer cell lines previously thought to be resistant to drugs, according to researchers at...

Shortened Androgen Receptor Allele Increases Risk.(Brief Article)(Statistical Data Included)
April 4, 2000... 2000 APR 4 - (NewsRx.com) -- A short androgen receptor (AR) allele increases the risk of ovarian cancer in women, regardless of whether a BRCA mutation is present, researchers say. Lifetime risk estimates for BRCA mutations for...

Phase I Study Explores MDXH210/Interferon {{gamma}} Combination in Cancer Patients.(Brief Article)(Statistical Data Included)
April 4, 2000... 2000 APR 4 - (NewsRx.com) -- Researchers from the United States explored the pharmacokinetic-pharmacodynamic (PK-PD) relationships of the bispecific antibody MDXH210 when it was combined with interferon gamma (IFN-{{gamma}}) in...

'Smart Scalpel' Detects Cancer Cells in Seconds.(Brief Article)(Statistical Data Included)
April 4, 2000... 2000 APR 4 - (NewsRx.com) -- A "smart scalpel" mechanism intended to detect the presence of cancer cells as a surgeon cuts away a tumor obscured by blood, muscle, and fat has been developed in prototype by scientists at the U.S....

Patent Issued for Double Minute Chromosome Technology.(Brief Article)(Statistical Data Included)
April 4, 2000... 2000 APR 4 - (NewsRx.com) -- NewBiotics, Inc., San Diego, California, announced the issuance of U.S. Patent 6,033,849, covering the method for isolating extrachromosomal amplified genes, developed jointly by NewBiotics and The Salk...

Growth Factor Concentration Not Correlated to Metastases, Disease Recurrence.(Brief Article)(Statistical Data Included)
April 11, 2000... 2000 APR 11 - (NewsRx.com) -- Although certain growth factors are considered to be responsible for angiogenesis, and ultimately to the development of tumors, recent study findings showed that such factors were not correlated with the...

Gene Transfer May Engraft New Specificities onto Lymphocytes.(Brief Article)(Statistical Data Included)
April 11, 2000... 2000 APR 11 - (NewsRx.com) -- A new class of chimeric receptors may be able to enhance the effectiveness of adoptive immunotherapy for treating cancer, according to researchers working in the United States. It may be possible to...

Lymphotactin Gene Transfer Improves Suicide Gene Therapy Efficacy.(Brief Article)(Statistical Data Included)
April 11, 2000... 2000 APR 11 - (NewsRx.com) -- Adenovirus-mediated lymphotactin gene transfer improved the therapeutic efficacy of cytosine deaminase suicide gene therapy in a murine model. "Lymphotactin (Ltn) is the sole member of C chemokines which...

Immune-Cell Mechanism Boosts Therapeutic Antibody Potency.(Brief Article)(Statistical Data Included)
April 11, 2000... 2000 APR 11 - (NewsRx.com) -- Researchers at the Rockefeller University, in collaboration with Genentech, Inc., have made a surprising discovery about the mechanism by which two currently-used clinical antibodies fight tumors. The...

MAb Conjugates Combined with Chemotherapy Enhance Tumor Kill.(Brief Article)(Statistical Data Included)
April 11, 2000... 2000 APR 11 - (NewsRx.com) -- Polymeric drugs based on conjugates of synthetic and natural macromolecules demonstrated enhanced anticancer activity when combined with chemotherapy, researchers in the Czech Republic reported. "We...

Phase I Study Evaluates Antibody C225 Alone and With Cisplatin.(Brief Article)(Statistical Data Included)
April 11, 2000... 2000 APR 11 - (NewsRx.com) -- Researchers in Spain evaluated anti-epidermal growth factor receptor chimeric antibody C225 alone and in combination with cisplatin for the treatment of cancer in Phase I trials. "The epidermal growth...

Therapy Combines Transduced Interleukin-12 Cells with Systemic Interleukin-18.(Brief Article)(Statistical Data Included)
April 11, 2000... 2000 APR 11 - (NewsRx.com) -- Researchers from Japan have evaluated a cancer therapy combining the transduction of cells with interleukin-12 given as a vaccine with systemic interleukin-18 administration. "We introduced the...

Epoxide-Containing Pirerazines Are Safe and Effective.(Brief Article)(Statistical Data Included)
April 11, 2000... 2000 APR 11 - (NewsRx.com) -- Epoxide-containing piperazines show potential as safe chemotherapeutic agents for refractory breast cancer, according to a report from the United States. G.F. Eilon and colleagues studied the potential...

Combination Regimen Increases Survival in Patients with Metastatic Disease.(Brief Article)(Statistical Data Included)
April 11, 2000... 2000 APR 11 - (NewsRx.com) -- A study published in the March 25, 2000 issue of the Lancet demonstrated that Camptosar (irinotecan hydrochloride injection) in combination with first-line therapy (5-fluorouracil/leucovorin [5-FU/LV])...

Combined Interleukin 12 and Indomethacin Inhibits Angiogenesis in Mice.(Brief Article)(Statistical Data Included)
April 11, 2000... 2000 APR 11 - (NewsRx.com) -- According to a study from Poland, inhibition of angiogenesis in mice was enhanced through a combined treatment of interleukin 12 and the antiinflammatory drug indomethacin. "Nonsteroidal anti-inflammatory...

NSAID Effectiveness Not Dependent on K-Ras Mutation.(Brief Article)(Statistical Data Included)
April 11, 2000... 2000 APR 11 - (NewsRx.com) -- A report in the American Journal of Physiology - Gastrointestinal and Liver Physiology refutes the conclusion, drawn from previous research, that nonsteroidal anti-inflammatory drugs (NSAIDs) are only...

Voxel Position Affects Brain Tumor Spectroscopy.(Brief Article)(Statistical Data Included)
April 11, 2000... 2000 APR 11 - (NewsRx.com) -- The accuracy of single-voxel magnetic resonance (MR) spectroscopy in evaluating brain tumors depends on voxel position. P.E. Ricci and colleagues from the Barrow Neurological Institute reported...

MAbs Detect Circulating Neuroblastoma Cells.(Brief Article)(Statistical Data Included)
April 11, 2000... 2000 APR 11 - (NewsRx.com) -- The combination of CD81/CD56/CD45 monoclonal antibodies (MAbs) is a specific and sensitive method for detecting circulating neuroblastoma cells in peripheral blood using flow cytometry, report researchers from...

Meta-Analysis Shows Risk Related to Hormone Levels.(Brief Article)(Statistical Data Included)
April 11, 2000... 2000 APR 11 - (NewsRx.com) -- In a recent study from the United States, researchers reported serum testosterone and insulin-like growth factor 1 levels are associated with an increased risk for prostate cancer. T. Shaneyfelt and...

Vaccinia Virus Ideal Vector for Tumor-Directed Gene Therapy.(Brief Article)(Statistical Data Included)
April 11, 2000... 2000 APR 11 - (NewsRx.com) -- Vaccinia virus (VV) is a useful vector for cancer-directed gene therapy, researchers from the United States reported. "Tumor-directed gene therapy, such as 'suicide gene' therapy, requires high levels of...

Naked Gene Delivery is Safe and Results in Tumor Reduction.(Brief Article)(Statistical Data Included)
April 11, 2000... 2000 APR 11 - (NewsRx.com) -- Delivery of naked therapeutic genes is safe and efficacious in animal model, according to a recent report. "The use of interleukin-2 (IL-2) and p53 for immunotherapy and gene therapy for cancer has shown...

MAb Detects Cytoplasmic Protein in Melanoma Samples.(Brief Article)(Statistical Data Included)
April 11, 2000... 2000 APR 11 - (NewsRx.com) -- NY-ESO-1 specific monoclonal antibodies (MAbs) were used to detect the NY-ESO-1 gene in neoplastic tissues, according to a report from Switzerland. "NY-ESO-1 gene encodes a novel member of the...

Modified Dendritic Cell Vaccine Effective in Murine Model.(Brief Article)(Statistical Data Included)
April 11, 2000... 2000 APR 11 - (NewsRx.com) -- Dendritic cells (DCs) modified by targeted adenoviral vectors acted as an effective vaccine in a murine model of human cervical cancer, reported researchers from the United States. "Increasingly, DC are...

NCI Study Finds Testing Effective when Used with ThinPrep Pap Test.(Brief Article)(Statistical Data Included)
April 11, 2000... 2000 APR 11 - (NewsRx.com) -- Cytyc Corp., Boxborough, Massachusetts, announced that preliminary results from the on-going U.S. National Cancer Institutes (NCI) ASCUS/LSIL Triage Study (ALTS) suggest that human papillomavirus (HPV)...

Repeated OvaRex Infusions Are Safe and Effective Treatment for Some.(Brief Article)(Statistical Data Included)
April 11, 2000... 2000 APR 11 - (NewsRx.com) -- The monoclonal antibody (MAb) OvaRex can be safely administered to ovarian cancer patients, reported a group of researchers from Germany, Canada, and the United States. "The standard of care for newly...

Results from Phase I Trial of Suicide Gene Therapy Encouraging.(Brief Article)(Statistical Data Included)
April 11, 2000... 2000 APR 11 - (NewsRx.com) -- Preliminary results from a Phase I clinical trial of adenovirus mediated suicide gene therapy for ovarian cancer are encouraging, reported researchers in the United States. "Our preclinical studies have...

Combination Therapy Has Synergistic Effect.(Brief Article)(Statistical Data Included)
April 11, 2000... 2000 APR 11 - (NewsRx.com) -- Researchers from Germany reported that a synergistic effect can be realized when p53 adenovirus mediated gene therapy is combined with 5-FU chemotherapy in pancreatic cancer cells. "Adenovirus mediated...

Genetically Targeted Adenovirus Vector Tackles Ovarian Cancer.(Brief Article)(Statistical Data Included)
April 11, 2000... 2000 APR 11 - (NewsRx.com) -- A genetically targeted adenovirus vector has been developed for suicide gene therapy of ovarian cancer. "Gene therapy trials for ovarian cancer have utilized vectors that have heretofore demonstrated...

E. coli Toxin to Enter Clinical Trials.(Brief Article)(Statistical Data Included)
April 11, 2000... 2000 APR 11 - (NewsRx.com) -- Select Therapeutics (SLPU), a Cambridge, Massachusetts-based biotechnology company developing cancer therapies, announced it has completed financial arrangements enabling it to move forward into clinical...

Phase I Tapet Human Intravenous Trial Approved.(Brief Article)(Statistical Data Included)
April 11, 2000... 2000 APR 11 - (NewsRx.com) -- Vion Pharmaceuticals, Inc. (VION), New Haven, Connecticut, announced it has received approval to begin a Phase I human clinical trial of a Tapet bacterial vector at the U.S. National Cancer Institute (NCI),...

Independent Studies Confirm Performance of Screening Products.(Brief Article)(Statistical Data Included)
April 11, 2000... 2000 APR 11 - (NewsRx.com) -- TriPath Imaging, Inc., Burlington, North Carolina, announced that six scientific studies have confirmed the successful use of both the AutoCyte PREP System (PREP) and the AutoPap Primary Screening System...

Patent Covers Dicationic Drugs as Cancer Therapies.(Brief Article)(Statistical Data Included)
April 11, 2000... 2000 APR 11 - (NewsRx.com) -- Immtech International Inc., Vernon Hills, Illinois, announced that through a licensing agreement with the company's University Scientific Consortium, it has been issued a patent for the use of its proprietary...

Treatment Approved for Inoperable Heptacellular Carcinoma.(Brief Article)(Statistical Data Included)
April 11, 2000... 2000 APR 11 - (NewsRx.com) -- MDS Nordion, a radioisotope technology company, received authorization from the U.S. Food and Drug Administration to market TheraSphere, a non-surgical outpatient therapy that uses microscopic glass beads to...

Hodgkin's Disease Survivors Are At Risk for Malignant Neoplasms.(Brief Article)(Statistical Data Included)
April 11, 2000... 2000 APR 11 - (NewsRx.com) -- Childhood survivors of Hodgkin's disease have a substantial risk for second malignant neoplasms (SMN) according to research published in the March 27, 2000, issue of the Journal of Clinical Oncology. The...

Growth Factor's Role in Metastasis Demonstrated.(Brief Article)
April 18, 2000... 2000 APR 18 - (NewsRx.com) -- Gene transfer of vascular endothelial growth factor (VEGF) into a LoVo human colon cancer cell line enhanced angiogenesis, tumor growth, and metastasis, researchers from Japan reported. "The expression of...

Discovery of Shark Cancers Casts More Doubt on Cartilage Pills.
April 18, 2000... 2000 APR 18 - (NewsRx.com) -- Businesses that sell shark cartilage as a cancer cure or preventive have claimed for years that sharks never get cancer. But scientists from Johns Hopkins University in Maryland and George Washington...

Anti-Cancer Therapy Uses Engineered Monoclonal Antibodies.
April 18, 2000... 2000 APR 18 - (NewsRx.com) -- Genetically engineered monoclonal antibodies (MAbs) can be used for direct anti-neoplastic treatment as well as cancer cell specific delivery of chemotherapeutic agents. "Classical therapeutic modalities...

Phase I/II Trial of AlloMune Cancer System Initiated.(Brief Article)
April 18, 2000... 2000 APR 18 - (NewsRx.com) -- BioTransplant Inc. (BTRN), Charlestown, Massachusetts, announced that enrollment and treatment has begun in a multi-center Phase I/II trial of the AlloMune Cancer System under an Investigative New Drug for...

Engrafting Costimulator Molecules Is Alternative to Transfection.(Brief Article)
April 18, 2000... 2000 APR 18 - (NewsRx.com) -- The engraftment of costimulator molecules onto tumor cell surfaces with chelator lipids is an alternative to gene transfection for cancer vaccines, researchers from Australia reported. "The genetic...

Human Anti-Idiotypic Antibody Evaluated as Treatment.(Brief Article)
April 18, 2000... 2000 APR 18 - (NewsRx.com) -- Researchers from England evaluated the human anti-idiotypic antibody, 105AD7, in a clinical trial of colon cancer. "Thirty-five patients received 105AD7 human anti-idiotype vaccination prior to surgery...

Pituitary-Tumor Transforming Gene May be Therapeutic Target.(Brief Article)
April 18, 2000... 2000 APR 18 - (NewsRx.com) -- Cedars Sinai Medical Center researchers suggest increases in the expression of pituitary tumor transforming gene (PTTG(1)) may function as a marker of invasive colorectal carcinoma and may serve as a new...

Protein Gene Product May Be Useful for Detecting Residual Disease.(Brief Article)
April 18, 2000... 2000 APR 18 - (NewsRx.com) -- Expression of protein gene product (PGP 9.5) might be used for detecting minimal residual disease for Ewing's sarcoma (ES) and peripheral primitive neuroectodermal tumor (pPNET), researchers say. "Small...

Molecular Remission Induced with Monoclonal Antibody.(Brief Article)
April 18, 2000... 2000 APR 18 - (NewsRx.com) -- Molecular remission of acute promyelocytic leukemia was induced with retinoic acid and the anti-CD33 monoclonal antibody HuM195, according to Memorial Sloan-Kettering Cancer Center workers. "Despite...

Oncogene Breakpoint Fusion Peptide Vaccine Generates Specific Responses.(Brief Article)
April 18, 2000... 2000 APR 18 - (NewsRx.com) -- Vaccination with bcr-abl oncogene breakpoint fusion peptides generated specific immune responses in patients with chronic myelogenous leukemia, reported a study from the United States. "Chronic...

Zadaxin Plus Chemotherapy Shows Promise in Skin Cancer.(Brief Article)
April 18, 2000... 2000 APR 18 - (NewsRx.com) -- SciClone Pharmaceuticals (SCLN), San Mateo, California, announced that a study published in Melanoma Research (April 2000;10(2)) suggests that Zadaxin increases the effectiveness of chemotherapy for metastatic...

Tissue Implantation Model More Useful than Cell Implantation Model.(Brief Article)
April 18, 2000... 2000 APR 18 - (NewsRx.com) -- Orthotopic tissue implantation (OTI) in a nitrosamine-induced hamster pancreatic cell line (HaP-T1) provides a more useful model for the study of pancreatic cancer than orthotopic cell implantation (OCI), say...

Genetic Basis for Development and Growth in Rats Identified.(Brief Article)
April 18, 2000... 2000 APR 18 - (NewsRx.com) -- by Jeff Bryan, Staff Medical Writer -- Researchers have identified susceptibility, resistance, and growth-promoting genes for rat stomach cancers induced by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) T....

DNA Repair Defective Cells Show Enhanced p53-Mediated Growth Suppression.(Brief Article)
April 18, 2000... 2000 APR 18 - (NewsRx.com) -- DNA repair defective T98G glioblastoma cells were found to enhance p53-mediated apoptosis and growth suppression, according to a recent study. "We have examined how the cellular DNA damage response and...

Supercomputers Engineer Two Novel Anticancer Agents.(Brief Article)
April 18, 2000... 2000 APR 18 - (NewsRx.com) -- BioNumerik Pharmaceuticals, Inc. presented data at the 91st Annual Meeting of the American Association of Cancer Research (AACR) in San Francisco, California, on two novel high performance computer engineered...

Results of Combretastatin Phase I Trial Announced.(Brief Article)
April 18, 2000... 2000 APR 18 - (NewsRx.com) -- New approaches are needed to treat solid malignant tumors that cannot be removed surgically and are resistant to traditional powerful chemotherapy drugs. In a Phase I clinical trial, a team of researchers...

Acetaminophen May Prevent Onset in Laboratory Animals.(Brief Article)
April 18, 2000... 2000 APR 18 - (NewsRx.com) -- A new study suggests that acetaminophen may prevent early biological changes that can lead to colon cancer in laboratory rats. The research by Gary M. Williams, MD, professor of Pathology at New York...

Researchers Examine Expression of Growth Factor Receptor.(Brief Article)
April 18, 2000... 2000 APR 18 - (NewsRx.com) -- Researchers recently investigated the rate of expression of different fibroblast growth factor receptor I isoforms in ovarian cystadenomas, LMPs, and carcinomas. Juan C. Felix and colleagues from...

Blocking 'Protein Export': Approach To Combat Cancer and Other Diseases.
April 18, 2000... 2000 APR 18 - (NewsRx.com) -- Scientists at Ciblex Corp., San Diego, California, reported the identification of a key protein sequence that permits a protein called fibroblast growth factor 2 (FGF2) to exit cancer cells and stimulate...

Infection Does Not Alter Vaccine Effectiveness.(Brief Article)
April 18, 2000... 2000 APR 18 - (NewsRx.com) -- Current human papillomavirus (HPV) infection should not alter the effectiveness of HPV vaccines, suggested researchers from the United States. "Current therapeutic vaccine strategies for HPV-induced...

Vaccine May Help Prevent Associated Cancers.
April 18, 2000... 2000 APR 18 - (NewsRx.com) -- Vaccination-acquired cell mediated immunity (CMI) may help prevent and treat human papillomavirus (HPV)-associated cancers, researchers from the United States reported. "Although most immunoprophylactic...

Clinical Data on Cancer Vaccine Presented.(Brief Article)
April 18, 2000... 2000 APR 18 - (NewsRx.com) -- Antigenics Inc. (AGEN), New York, New York, announced the release of data from a Phase I/II melanoma clinical trial of the company's cancer vaccine, Oncophage. Dr. Omar Eton, M.D. Anderson Cancer Center...

Ganciclovir Delivery Systems Explored for Suicide Gene Therapy.
April 18, 2000... 2000 APR 18 - (NewsRx.com) -- Microspheres are useful for delivering ganciclovir (GCV) into the peritoneal cavity for suicide gene therapy of ovarian cancer, researchers from the United States reported. "The objective of this research...

Angiogenesis Inhibitor Shows Promising Results.(Brief Article)
April 18, 2000... 2000 APR 18 - (NewsRx.com) -- In a recent study from the United States, researchers reported SU6668, a novel tyrosine kinase angiogenesis inhibitor, exhibited potent anti-tumor activity in mice models. A.D. Laird and colleagues from...