Cancer Weekly articles from April 1992

Cancer Weekly archives from April 1992

Company supplies taxol produced by cell culture technology to NCI. (National Cancer Institute) (ESCAgenetics Corp.)
April 6, 1992... ESCAgenetics Corp. ESCAgenetics Corp. announced that it is supplying Taxol produced by its proprietary cell tissue culture technology to the U.S. National Cancer Institute (NCI) for analytical evaluations. Produced in the company's...

Taxol popular topic at society meeting. (American Chemical Society)
April 6, 1992... American Chemical Society Taxol, the anticancer drug made from yew trees, is the subject of some 15 scientific papers presented at the American Chemical Society's 203rd national meeting, held April 5-10, 1992. Research on the drug...

Study clarifies tumor necrosis factor contribution to disease states. (University of California, Los Angeles)
April 6, 1992... University of California, Los Angeles A new study based at the University of California at Los Angeles (UCLA) School of Medicine has shed light on the physiological mechanisms whereby tumor necrosis factor (TNF) can have a duplicitous...

Applied Immune Sciences receives approval to begin breast cancer trials. (autologous bone marrow treatment technology; AIS CELLector) (U.S. Food and Drug Administration)
April 6, 1992... U.S. FDA Applied Immune Sciences Inc. (AIS) announced that it has received approval from the U.S. Food and Drug Administration (FDA) to commence clinical trials of its autologous bone marrow treatment for breast cancer. The company...

NCI doubles funding for prostate cancer. (U.S. National Cancer Institute)
April 6, 1992... U.S. NCI U.S. National Cancer Institute (NCI) funding for prostate cancer research in 1992 is expected to reach $28 million - double 1991's expenditure. According to a report in the Journal of the National Cancer Institute, the...

Environmental toxins implicated in new breast cancer study. (PCBs) (Michigan)
April 6, 1992... Michigan The widespread industrial toxins known as PCBs may play a key role in breast cancer in women, a researcher said. Dr. Frank Falck Jr. of the University of Michigan said his pilot study found higher than normal levels of...

EuroCetus receives approval to market Proleukin in former USSR territories. (interleukin-2) (The Netherlands)
April 6, 1992... The Netherlands EuroCetus B.V., a fully integrated oncology business unit of Chiron Corp. based in Amsterdam, announced that it has received approval in the former territories of the Soviet Union to market Proleukin (interleukin-2, IL-2)...

Chernobyl inflicts heavy toll on health. (1986 nuclear plant accident) (Ukraine)
April 6, 1992... Ukraine Ukrainian authorities issued startling new figures on illnesses caused by the 1986 Chernobyl disaster and asked anew for global aid to cope with the legacy of the world's worst nuclear plant accident. The Ukraine's...

EPA's passive smoking assessment to be released. (U.S. Environmental Protection Agency)
April 6, 1992... U.S. EPA A risk assessment analysis of passive smoking is expected to be released by the U.S. Environmental Protection Agency (EPA) later in 1992, and the report will likely designate passive smoke as a Class A carcinogen. The...

Insurer clarifies silicone-gel breast implant policy. (Blue Cross of California)
April 6, 1992... Blue Cross of California A random telephone survey of health insurance companies included in the March 1992 issue of the Health Harbinger did not accurately reflect the comprehensive nature of Blue Cross of California's policy, according...

Robotic technology reduces radiation exposure and shortens treatment. (high-dose-rate remote afterloading for radiotherapy) (Thomas Jefferson University, Philadelphia, Pennsylvania)
April 6, 1992... Pennsylvania A remote-controlled device is enabling radiation oncologists at Thomas Jefferson University, Philadelphia, Pennsylvania, to deliver higher doses of radiation to destroy tumors in less time than was previously possible. ...

Junked technology helps detect implant leaks. (xerography technique of mammography) (McKee Medical Center, Loveland, Colorado)
April 6, 1992... McKee Medical Center A piece of equipment once destined for the rubbish heap is being used by a Loveland, Colorado, hospital to detect leaking silicone breast implants. Doctors at McKee Medical Center have returned to service a...

Company forms Cadus to develop novel drugs for cancer. (Cadus Pharmaceutical Corp.) (ImClone Systems)
April 6, 1992... ImClone Systems ImClone Systems Inc. announced that they have formed Cadus Pharmaceutical Corp. to develop novel drugs for the treatment of cancer, inflammation and allergy which are based on signal transduction mechanisms in human...

Company expands phase I clinical trials of novel therapeutic vaccine for malignant melanoma. (BEC-2) (ImClone Systems)
April 6, 1992... ImClone Systems ImClone Systems Inc., New York City, announced the expansion of Phase I clinical trials of its novel therapeutic vaccine, BEC-2, for malignant melanoma. The new protocol includes earlier stage cancer patients, as...

Cut-backs for high cancer-risk products forced under Proposition 65. (California) (Environmental Defense Fund)
April 6, 1992... Environmental Defense Fund A series of court orders and innovative settlements achieved under California's landmark Proposition 65 is restructuring the market for paint strippers and related products that carry high cancer risks, the...

Final rules on radiation exposure compensation act release. (U.S. Department of Justice)
April 6, 1992... U.S. Department of Justice The U.S. Department of Justice announced that Attorney General William P. Barr has signed the final regulations to officially implement the Radiation Exposure Compensation Act of 1990. The regulations...

Radiation treatment of eye tumors allows patients to keep vision. (choroidal melanoma and retinoblastoma) (Hahnemann University, Philadelphia, Pennsylvania)
April 6, 1992... Pennsylvania Hahnemann University, Philadelphia, Pennsylvania, physicians advocate the use of radiation treatment of eye tumors, allowing more patients to keep both their vision and their lives. "Many physicians treat eye cancer the...

Increase of interstitial fluid pressure in tumors following photodynamic therapy. (Research Report)
April 6, 1992... Increase of Interstitial Fluid Pressure in Tumors AUTHORS: M. Leunig, A.E. Goetz, G. Zetterer, K. Messmer and R.K. Jain. University of Munich, Munich, Germany; and Harvard Medical School, Massachusetts General Hospital, Boston,...

Chemoprotection of epithelial cells in culture by vitamins C and E. (Research Report)
April 6, 1992... Chemoprotection of Epithelial Cells in Culture by AUTHORS: R.S. Pieters, G. Liu, E. Christofidis and R. Stephens. Arthur G. James Cancer Hospital and Research Institute, Columbus, Ohio. According to the authors' abstract of a...

Radioprotection of human peripheral blood lymphocytes by interleukin-1 (IL-1) and tumor necrosis factor (TNF). (Research Report)
April 6, 1992... AUTHORS: Sun-san J. Sung, David T. Huang, Peck-Sun Lin, Rupert Schmidt-Ullrich and Jay A. Walters. Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia. According to the authors' abstract of a presentation to the...

Effect of tumor hypoxia on the efficacy of SR 4233 combined with fractionated irradiation. (Research Report)
April 6, 1992... AUTHORS: I.H. Kim, M.J. Lemmon and J.M. Brown. Stanford University School of Medicine, Stanford, California. According to the authors' abstract of a presentation to the 40th annual meeting of the Radiation Research Society, held March...

Age-dependent radiation nephropathy in rats given fractionated irradiation. At what age is it a factor? (Research Report)
April 6, 1992... AUTHORS: B.L. Fish and J.E. Moulder. Medical College of Wisconsin, Milwaukee, Wisconsin. According to the authors' abstract of a presentation to the 40th annual meeting of the Radiation Research Society, held March 14-18, 1992, in Salt...

Evidence for individual differences in the radiosensitivity of human skin. (Research Report)
April 6, 1992... AUTHORS: S.L. Tucker, I. Turesson and H.D. Thames. M.D. Anderson Cancer Center, Houston, Texas. According to the authors' abstract of a presentation to the 40th annual meeting of the Radiation Research Society, held March 14-18, 1992,...

Effects of suramin on in vitro growth of fresh human tumors. (Periodical Report)
April 6, 1992... SOURCE: Journal of the National Cancer Institute, April 1, 1991;84(7):489-494. In tests on various fresh human tumors in vitro, the polysulfonated urea suramin showed significant anticancer activity against mesothelioma, malignant...

Carboplatin: an active drug in metastatic breast cancer. (Periodical Report)
April 6, 1992... SOURCE: Journal of Clinical Oncology, March, 1992;10(3):433-437. Carboplatin shows activity in the treatment of metastatic breast cancer patients without previous exposure to chemotherapy, according to a report from a Spanish research...

Differential expression of the CD44 molecule in human brain tumors. (Periodical Report)
April 6, 1992... SOURCE: International Journal of Cancer, 1992;50:572 -577. There appears to be a significant increase in the expression of the CD44 molecule in high-grade gliomas compared with normal brain or other brain-tumor types such as meningiomas...

Heterogeneity for allelic loss in human breast cancer. (Periodical Report)
April 6, 1992... SOURCE: Journal of the National Cancer Institute, April 1, 1992;84(7):506-510. Loss of heterozygosity (LOH) in breast cancers appears to occur most frequently at specific regions, strongly suggesting that LOH is not the result of random...

Successful treatment of human acute T-cell leukemia in SCID mice using the anti-CD7-deglycosylated ricin A-chain immunotoxin DA7. (severe combined immunodeficiency disease) (Periodical Report)
April 6, 1992... SOURCE: Cancer Research, March 1, 1992;52:1314-1321. The immunotoxin DA7 appears to be an effective in vivo therapeutic agent against human T acute lymphoblastic leukemia (MT-ALL) in the SCID mouse system, suggesting a potential use for...

Carcinoembryonic antigen and carbohydrate 19-9 antigen as markers for colorectal carcinoma in children and adolescents. (Periodical Report)
April 6, 1992... SOURCE: Cancer, March 15, 1992;69(6):1487-1491. Carcinoembryonic antigen (CEA) and carbohydrate 19-9 antigen (CA 19-9) are not effective markers for the detection of recurrent or progressive colorectal cancer in children and adolescents,...

Doctors to begin gene therapy in treatment of cancer. (University of Michigan Medical Center)
April 20, 1992... University of Michigan Medical Center Doctors at the University of Michigan (UM) Medical Center will make the world's first attempt to treat cancer in humans by injecting a gene directly into a tumor. The study, announced April 13,...

Prostate-specific antigen levels a marker for prostate cancer. (Johns Hopkins University)
April 20, 1992... Johns Hopkins University Large changes in a man's level of prostate-specific antigen (PSA) may be an early warnlng sign for prostate cancer, according to a study published in the April 22, 1992, issue of the Journal of the American...

Risk of prostate cancer may be determined by enzyme. (5 alpha reductase) (University of Southern California)
April 20, 1992... University of Southern California An enzyme that acts on the male hormone testosterone may play a key role in causing prostate cancer and help to explain the wide variation in prostate cancer rates among races. Researchers at the...

Efficacy of radical treatments for early-stage prostate cancer unproven. (Sweden)
April 20, 1992... Sweden Radical treatments for untreated, early-stage prostate cancer should be considered experimental until further studies are done, according to a study in the April 22, 1992, issue of the Journal of the American Medical Association....

Doctor: ultrasound test helps find men at risk of prostate cancer. (Dr. Fred Lee) (American Cancer Society)
April 20, 1992... American Cancer Society A blood test that can indicate possible prostate cancer can be made more useful when combined with an ultrasound examination of the prostate, a researcher said. The ultrasound examination shows whether high...

Drug review initiatives announced. (U.S. Food and Drug Administration)
April 20, 1992... U.S. FDA Vice President Dan Quayle and U.S. Department of Health and Human Services (HHS) Secretary Louis W. Sullivan, M.D., announced that four initiatives are being implemented by the U.S. Food and Drug Administration (FDA) to speed...

Pine trees yield starting material for taxol synthesis. (Stanford University)
April 20, 1992... Stanford University In the key to their progress toward synthesizing the drug taxol in the laboratory, Stanford University chemists have found an inexpensive starting material found in pine trees. They described their findings at...

Panel temporarily okays continued sales of acne drug. (benzoyl peroxide) (U.S. Food and Drug Administration)
April 20, 1992... U.S. FDA One of the most widely used acne medications should continue to be sold as an over-the-counter product while further research establishes whether it is safe, a U.S. Food and Drug Administration (FDA) advisory panel recommended....

Saccharin-caused cancer may be limited to rats. (Dr. Sam Cohen's research) (Federation of American Societies for Experimental Biology meeting)
April 20, 1992... FASEB Despite warning labels that saccharin may be hazardous to human health, a new study suggests the artificial sweetener's ability to cause cancer may be limited solely to rats, a Nebraska researcher said. "Given what we know...

ABMT has benefits for metastatic breast cancer, but may be too expensive. (autologous bone marrow transplants) (Medical College of Virginia)
April 20, 1992... Medical College of Virginia Autologous bone marrow transplants (ABMT) for metastatic breast have proven benefits, but at a cost that may be untenable, notes an article in the April 15, 1992, issue of the Journal of the American Medical...

Study says obesity may raise risk of breast cancer recurrence. (American Cancer Society)
April 20, 1992... American Cancer Society Breast cancer patients who were obese at the time of diagnosis ran a higher risk of getting the disease again than did thinner women, a new study found. Women who were at least 25 percent heavier than their...

Protein in cow's milk slows growth of cancer cells in lab tests. (mammary-derived growth inhibitor) (Cornell University)
April 20, 1992... Cornell University Laboratory tests show a protein found in cow's milk slows the growth of human breast cancer cells, according to a Cornell University scientist. Ronald Gorewit said that the protein, known as MDGI, may someday...

Three-dimensional treatment planning allows higher radiation doses. (University of Michigan)
April 20, 1992... University of Michigan Researchers at the University of Michigan have been able to increase the radiation dosage to patients with prostate cancer by 10 to 15 percent due to three-dimensional treatment planning, and the technique is...

A new system to study radiation-induced neoplastic cell transformation in human mammary epithelial cells. (Research Report)
April 20, 1992... AUTHORS: L. Craise, T. Yang, M. Durante and M. Stampfer. Lawrence Berkeley Laboratory, Berkeley, California, and the University of Naples, Naples, Italy. According to the authors' abstract of a presentation to the 40th annual meeting of...

Tumoricidal activity and cytokine secretion of human monocytes and alveolar macrophages is modulated by a synthetic peptide of C-reactive protein (CRP). (Research Report)
April 20, 1992... AUTHORS: M.J. Thomassen, J. Antal, M. Connors, H. Wiedemann, D. Meeker, D. Eppstein, S. Deodhar and B. Barna. Cleveland Clinic, Cleveland, Ohio. According to the authors' abstract of a poster presentation to the annual meeting of the...

Enhanced growth of murine TIL cells and human lymphocytes in experimental culture fluid. (Research Report)
April 20, 1992... AUTHORS: Anthony R. Torres, Reed P. Warren, Roger A. Burger and Rex Spendlove. Utah State University, Logan, Utah. According to the authors' abstract of a poster presentation to the annual meeting of the Federation of American Societies...

Inhibition of melanoma cell invasion by sphingosine derivatives. (Research Report)
April 20, 1992... AUTHORS: Y. Sadahira, Y. Igarashi, F. Ruan and S. Hakomori. The Biomembrane Institute and Department of Pathobiology, University of Washington, Seattle, Washington. According to the authors' abstract of a poster presentation to the...

Increased TIMP-1 activity, protein, and gene expression in human breast carcinoma desmoplasia. (Research Report)
April 20, 1992... AUTHORS: I. Hu, I. Cheng and S. Barsky. University of California at Los Angeles. According to the authors' abstract of a poster presentation to the annual meeting of the Federation of American Societies for Experimental Biology, held...

Activation of protein kinase A stimulates tumor metastasis. (Research Report)
April 20, 1992... AUTHORS: Y. Lozano, J. Bagash and M.E. Young. Loyola University School of Medicine, Maywood, Illinois. According to the authors' abstract of a poster presentation to the annual meeting of the Federation of American Societies for...

Expression of different forms of cathepsin B mRNA transcripts in normal human tissues and tumors. (Research Report)
April 20, 1992... AUTHORS: Q. Gong, S.J. Chan, A.S. Bajikowski, D.F. Steiner and A. Frankfater. Loyola University, Maywood, Illinois. According to the authors' abstract of a poster presentation to the annual meeting of the Federation of American...

Building better vaccines for B-cell lymphoma. (Research Report)
April 20, 1992... AUTHORS: Mi-Hua Tao and Ronald Levy. Stanford University Medical School, Stanford, California. According to the authors' abstract of a poster presentation to the annual meeting of the Federation of American Societies for Experimental...

High-dose chemotherapy with autologous bone marrow transplantation for the treatment of metastatic breast cancer. (Periodical Report)
April 20, 1992... SOURCE: Journal of Clinical Oncology, April, 1992;10(4):657-670. Existing evidence does not demonstrate that high-dose chemotherapy with autologous bone marrow transplantation is superior to conventional chemotherapy in the treatment of...

Identification of ras oncogene mutations in the stool of patients with curable colorectal tumors. (Periodical Report)
April 20, 1992... SOURCE: Science, April 3, 1992;256:102-105. Colorectal tumors can be detected by a noninvasive method from the stool of patients based on the molecular pathogenesis of the disease, according to a report from Johns Hopkins University and...

Phase I and pharmacologic study of topotecan: a novel topoisomerase I inhibitor. (Periodical Report)
April 20, 1992... SOURCE: Journal of Clinical Oncology, April, 1992;10(4):647-656. The captothecin analog topotecan may have clinical activity in the treatment of platinum-refractory ovarian cancer and non-small-cell lung cancer, according to a Phase I...

Breast conservation versus mastectomy: is there a difference in psychological adjustment or quality of life in the year after surgery? (Periodical Report)
April 20, 1992... SOURCE: Cancer, April 1, 1992;69(7):1729-1738. Women receiving breast conservation surgery may require more intensive psychosocial intervention due to postoperative radiation therapy, according to a report from the University of...

Clustering of adverse drug events: analysis of risk factors for cerebellar toxicity with high-dose cytarabine. (Periodical Report)
April 20, 1992... SOURCE: Journal of the National Cancer Institute, April 1, 1992;84(7):500-505. A study by the U.S. Food and Drug Administration (FDA) found that there is a significantly higher incidence of cerebellar toxicity with high-dose cytarabine...

New breast cancer data released. (Annual Review of Patient Care) (American Cancer Society)
April 27, 1992... American Cancer Society The American Cancer Society (ACS) has completed its first Annual Review of Patient Care from the ACS's National Cancer Data Base (NCDB). The Review analyzes four disease sites (colon, lung, and breast cancer...

Taxol breakthrough announced. (University of Kansas)
April 27, 1992... University of Kansas A new development in cancer research was announced April 20, 1992, by the University of Kansas (KU), Lawrence, Kansas, where a researcher has made a contribution to solving the supply problem of taxol, an anticancer...

Breast cancer conference covers diagnostic techniques/disease incidence. (American College of Radiology)
April 27, 1992... American College of Radiology Ultrasound-guided fine needle aspiration biopsy is a highly accurate alternative to surgical biopsy, according to the results of a two-and-one-half-year study of the technique by Canadian researchers. ...

Agency announces silicone breast implant decision. (U.S. Food and Drug Administration)
April 27, 1992... U.S. FDA The U.S. Food and Drug Administration (FDA) announced that silicone breast implants will be available only under controlled clinical studies. Women who need these implants for reconstruction will be assured access to those...

Society welcomes FDA decision on breast implants. (American Society of Plastic and Reconstructive Surgeons)
April 27, 1992... The American Society of Plastic and Reconstructive Surgeons (ASPRS) said it welcomes the U.S. Food and Drug Administration's (FDA) announcement that it is lifting the moratorium on the use of silicone-gel breast implants for women with "urgent...

Plastic surgeons say decision on implants is "too little, too late." (American Society for Aesthetic Plastic Surgery)
April 27, 1992... The U.S. Food and Drug Administration's (FDA) decision to allow the use of silicone gel-filled breast implants for reconstructive surgery in breast-cancer patients, but to tightly restrict their use for cosmetic purposes, received both praise...

First state-court breast implant class action certified. (Louisiana)
April 27, 1992... U.S. Judge Joseph DiRosa, of New Orleans, certified a state opt-out class action for women and their families alleging injury or adverse health effects due to silicone gel-filled breast implants in the case of Marilyn Spitzfaden v. Dow...

TRAM allows surgical alternative to breast implants. (transverses rectus abdominus myocutaneous) (Rush-Presbyterian-St. Luke's Medical Center)
April 27, 1992... Controversy over silicone implants is prompting plastic surgeons to investigate alternatives for women who've had mastectomies. One of the newest options is microvascular TRAM (transverses rectus abdominus myocutaneous), in which the breast...

Smoking linked to HIV risk. (study of Haitian women)
April 27, 1992... A study of Haitian women shows that moderate cigarette smokers are 3.4 times more likely than nonsmokers to have HIV infection. This link between smoking and risk of HIV infection persists even when the analysis takes into account other...

Researcher hopes product will relieve mental cravings for cigarettes. (Dr. Jed E. Rose; device that delivers spritz of citric acid) (North Carolina)
April 27, 1992... A researcher who invented the nicotine patch to help smokers kick the habit has designed a new tool that he hopes will do what the patch does not - relieve the psychological craving for a cigarette. The new tool uses puffs of citric acid,...

Researchers find strong link between viruses, one male cancer. (human papillomaviruses, penile cancer) (Duke University)
April 27, 1992... Using new technology to study samples from Duke's extensive "tumor library," researchers at the Duke Comprehensive Cancer Center, Durham, North Carolina, have found a strong correlation between the presence of two relatively common viruses and...

Characterization of cells mechanically isolated from breast tumors. (Research Report)
April 27, 1992... AUTHORS: D.P. Halpin, W.E. Moody, W.S. Blakemore and E.V. Gaffney. Baptist Medical Systems, Birmingham, Alabama. According to the authors' abstract of a presentation to the 83rd annual meeting of the American Association for Cancer...

Pattern recognition optimized magnetic resonance imaging of cancer. (Research Report)
April 27, 1992... AUTHORS: C.C. Badger, J. Smith and B. Porter. Fred Hutchinson Cancer Research Center and First Hill Diagnostic Imaging Center, Seattle, Washington. According to the authors' abstract of a presentation to the 83rd annual meeting of the...

Expression of c-erbB-2 oncoprotein in prostate cancer. (Research Report)
April 27, 1992... AUTHORS: E.J. Kuhn, I.A. Sesterhenn, E.H. Chang and J.W. Moul. Uniformed Services University of the Health Sciences, Bethesda, Maryland. According to the authors' abstract of a presentation to the 83rd annual meeting of the American...

Prognostic importance of occult lymph node metastases in patients with breast cancer. (Research Report)
April 27, 1992... AUTHORS: R. Cote, B. Chaiwun, J. Ou, C. Taylor, H. Peterson, R. Belber, A. Goldhirsch and A.M. Neville. University of Southern California School of Medicine at Los Angeles and the International (Ludwig) Breast Cancer Study Group, Bern and...

Why do so many promising prognostic factors fail to pan out? (Research Report)
April 27, 1992... AUTHORS: S.G. Hilsenbeck, G.M. Clark and W.L. McGuire. The University of Texas Health Sciences Center, San Antonio, Texas. According to the authors' abstract of a presentation to the 83rd annual meeting of the American Association for...

Acute lymphoblastic leukemia with t(4;11) translocation expresses the myeloperoxidase gene. (Research Report)
April 27, 1992... AUTHORS: M. Zhou, H. Findley, S. Zaki and A.H. Ragab. Emory University School of Medicine, Atlanta, Georgia. According to the authors' abstract of a presentation to the 83rd annual meeting of the American Association for Cancer...

Monitoring the excretion of modified nucleosides by cancer patients with a six-monoclonal-antibody set in a solid-phase immunoassay. (Research Report)
April 27, 1992... AUTHORS: C. Reynaud, C. Bruno, P. Estrabaud, S. Barbesti and A. Niveleu. Laboratory de Genie Enzymatique, Billeurbanne, France. According to the authors' abstract of a presentation to the 83rd annual meeting of the American Association...

Continuation of follow-up of DES-exposed cohorts. (diethylstilbestrol) (National Cancer Institute research contract announcement) (Research Report)
April 27, 1992... AUTHORS: RFP Available: NCI-CP-33011-21. U.S. National Cancer Institute. "The National Cancer Institute (NCI) is seeking investigators in a collaborative effort to continue follow-up of surviving members of a cohort exposed to DES...

Clinical cancer therapy research. (National Cancer Institute research grant announcement) (Research Report)
April 27, 1992... AUTHORS: PA Number: PA-92-69. U.S. National Cancer Institute. Purpose: The National Cancer Institute (NCI) seeks grant applications to conduct clinical therapeutic studies of neoplastic diseases in humans. Clinical research, by...

5-alpha-reductase activity and risk of prostate cancer among Japanese and U.S. white and black males. (Periodical Report)
April 27, 1992... SOURCE: The Lancet, April 11, 1992;339:887-889. Reduced 5alpha-reductase activity may be responsible in part for the low rate of prostate cancer among Japanese men, according to a study from UCLA and Japan's Gifu University. ...

Presence of Epstein-Barr virus in Hodgkin's disease is not exclusive to Reed-Sternberg cells. (Periodical Report)
April 27, 1992... SOURCE: American Journal of Pathology, April, 1992;140(4):757-762. Epstein-Barr virus is present in certain Hodgkin's Disease tissues, but this does not necessarily indicate a role for the virus in the disease process, according to a...

Evaluation of seven tumor markers (CA 50, CA 19-9 TruQuant, CA 72-4, CA 195, carcinoembryonic antigen, and tissue polypeptide antigen) in the pretreatment sera of patients with gastric carcinomas. (Periodical Report)
April 27, 1992... SOURCE: Cancer, April 15, 1992;69(8):2036-2041. Preoperative determination of serum tumor marker levels in patients with gastric cancers currently has no significance in clinical practice, according to a report from The Netherlands'...

Radiation therapy and fluorouracil with or without semustine for the treatment of patients with surgical adjuvant adenocarcinoma of the rectum. (Periodical Report)
April 27, 1992... SOURCE: Journal of Clinical Oncology, April, 1992;10(4):549-557. Treatment with semustine is not an essential component of postoperative combined modality in the adjuvant treatment of rectal cancer, and should not be included in future...

Expression of 44-kilodalton oncofetal antigen as a premalignancy marker in X irradiation-induced murine T-cell lymphoma. (Periodical Report)
April 27, 1992... SOURCE: Journal of the National Cancer Institute, April 15, 1992;84(8):602-609. A study from the University of South Alabama found that the expression of oncofetal antigens (OFAs) significantly preceded histologic evidence of malignant...