AIDS Weekly articles from September 1994

AIDS Weekly archives from September 1994

Panel: empowerment of women needed to halt AIDS. (X International Conference on AIDS)
September 5, 1994... X International Conference on AIDS The education and empowerment of women are needed to halt the heterosexual spread of AIDS, according to a panel of experts convened at the X International Conference on AIDS, held August 7-12, 1994, in...

Economic vulnerability of women adds to AIDS risk.
September 5, 1994... X International Conference on AIDS Women are often dependent upon men, and this puts them at greater risk of HIV infection, according to a U.S. researcher. Ellen Weiss, of the nonprofit organization International Center for Research...

First true primate model for AIDS. (Macaca nemestrina monkeys)
September 5, 1994... X International Conference on AIDS AIDS research now has a powerful new tool: a relevant primate model of AIDS. A major difficulty in understanding the pathogenesis of HIV disease - and in developing AIDS vaccines and therapies -...

Chimp study supports attenuated HIV vaccine.
September 5, 1994... X International Conference on AIDS Chimpanzee studies suggest that an attenuated HIV vaccine could protect against infection by heterologous HIV strains. A chimpanzee protected against high-dose HIV challenge had very low levels of...

Second macaque subspecies infected with HIV-1. (Macaca nemestrina leonina)
September 5, 1994... X International Conference on AIDS A second subspecies of macaque monkeys can be infected with HIV-1, according to a report at the X International Conference on AIDS, held August 7-12, 1994, in Yokohama, Japan. Michael B. Agy of the...

HIV/canary pox vaccine protects, but needs peptide boost.
September 5, 1994... X International Conference on AIDS Four of 10 monkeys vaccinated with a recombinant canarypox/HIV-2 vaccine and boosted with synthetic HIV-2 peptides were protected against challenge with infectious HIV-2, researchers reported at the X...

Animal model for testing env-based HIV-1 vaccines.
September 5, 1994... X International Conference on AIDS Two separate research laboratories have successfully infected monkeys with chimeric simian immunodeficiency virus (SIV) viruses genetically engineered to express HIV-1 proteins. Both chimeric...

Codon 215 mutations negatively affect children with AIDS.
September 5, 1994... Zidovudine Resistance As in adults with human immunodeficiency virus (HIV) disease, the appearance of HIV-1 codon 215 mutation seems to be strongly associated with zidovudine resistance and clinical progression in children with AIDS,...

Mutation at codon 74 involved in didanosine resistance.
September 5, 1994... HIV-Infection More than half of HIV-infected patients switched from zidovudine to didanosine monotherapy developed didanosine resistance mutation at codon 74 within six months, in a study conducted by researchers from the Stanford...

Fluconazole-resistant Candida more frequent in IVDU. (intravenous drug users)
September 5, 1994... AIDS Related Illness Oral candidiasis and fluconazole-resistant Candida isolates are more frequently found in HIV-positive patients who are intravenous drug users, according to a report from France's Bocage Hospital. Researcher...

P. carinii resistant to imidazole antifungal agents. (Pneumocystic carinii)
September 5, 1994... AIDS-Related Illness The AIDS-associated illness Pneumocystis carinii is resistant to imidazole antifungal agents, according to a report from the Indiana University School of Medicine. P. carinii is an important cause of morbidity...

ATIN has new publisher. (AIDS Targeted Information, Libex Inc.)
September 5, 1994... AIDS Newsletters AIDS Targeted Information (ATIN), a monthly AIDS literature digest, now is available directly from a New York publisher. Formerly available from Baltimore, Maryland, publisher Williams & Wilkins or from the American...

Genes thought to exist in HIV could lead to AIDS treatment.
September 5, 1994... Industry News The existence of previously unnoticed genes in HIV is being predicted by researchers at the University of Georgia, Athens. They believe it is possible that one of these genes, in the presence of a particular amino acid,...

Antiviral medication advances to clinical trials. (compound 524W91)
September 5, 1994... Industry News A potential new antiviral agent, being developed in a collaborative effort involving scientists at Burroughs Wellcome Company and Emory University, Atlanta, Georgia, has moved into Phase I safety studies in individuals...

DOX-SL effective for treatment of Kaposi's sarcoma. (doxorubicin with stealth liposomes)
September 5, 1994... Clinical Trial DOX-SL, a formulation of doxorubicin encapsulated in Stealth liposomes, was shown to be an effective agent for the treatment of AIDS-related Kaposi's sarcoma (KS) in data presented at the X International Conference on AIDS...

Urine test detects HIV-positive subjects in study.
September 5, 1994... International Speaking on the opening day of the X International Conference on AIDS, held in Yokohama, Japan, August 7-12, 1994, Dr. Yamazuki, Director General of the Japanese National Institutes of Health (NIH), presented the results of...

P24 antigen testing detects unsuspected HIV-1 infection.
September 5, 1994... HIV-1 Infection Researchers from Alabama suggested that p24 antigen testing may be an effective adjunct to HIV-1 antibody testing to determine HIV-1 infection in populations with a high seroprevalence of infection. Stephen J. Clark,...

Phase I/II clinical data on Isis 2922 for CMV retinitis. (cytomegalovirus)
September 5, 1994... X International Conference on AIDS Alan Palestine, M.D., a clinical investigator for Isis Pharmaceuticals Inc., Carlsbad, California, described the results of the company's Phase I/II clinical study with Isis 2922, an antisense...

Greater effort to find HIV status of TB patients needed. (tuberculosis)
September 5, 1994... U.S. CDC A U.S. Centers for Disease Control and Prevention (CDC) report suggests that HIV-infected persons accounted for at least 50 percent of the excess tuberculosis (TB) cases in the United States from 1985 through 1992. ...

AFB has high TB predictive value when MAC common. (acid-fast bacilli, tuberculosis, Mycobacterium avium complex)
September 5, 1994... TB and AIDS In a University of California hospital where Mycobacterium avium complex (MAC) is the predominant Mycobacterium species isolated, a positive acid-fast smear had a 92 percent predictive value for Mycobacterium tuberculosis...

Researchers find new way to inhibit HIV. (using a complex of gold and cyanide)
September 5, 1994... Treatment Researchers at the University of Cincinnati (UC), Ohio, have evidence that a complex of gold and cyanide can inhibit replication of HIV in cell cultures. Katherine Tepperman, associate professor of biological sciences,...

Effects of thalidomide on wasting syndrome in patients with AIDS: a randomized, double-blind, placebo controlled clinical trial. (Research Report)
September 5, 1994... AUTHORS: G. Reyes-Teran, J.G. Sierra-Madero, V. Martinez del Cerro, T. Munoz-Trejo, H. Arroyo-Figueroa, A. Pasquetti, J.J. Calva and G.M. Ruiz-Palacios. Instituto Nacional de la Nutricion, Mexico City, Mexico. According to an abstract...

Growth hormone therapy of AIDS wasting. (Research Report)
September 5, 1994... AUTHORS: M. Schambelan 1, A. LaMarca 2, K. Mulligan 1, C. Grunfeld 1, S. Kennedy 3, J. Breitmeyer 3 and E. Daar 4. 1University of California, San Francisco, California; 2Therafirst Fort Lauderdale, Florida; 3Serono Laboratories; 4Cedars...

Immunological characteristics of HIV-infected non-progressors. (Research Report)
September 5, 1994... AUTHORS: P.J. Easterbrook 1, S. Foster 1, D. Henderson 1, M. Crane 1, L.M. Yu 1, J. Weber 2 and B.G. Gazzard 1. 1Chelsea and Westminster Hospital, London; 2Saint Marys Hospital, London, United Kingdom. According to an abstract submitted...

Further studies on the ability of lithium (Li) to minimize the blood cell toxicity of AZT. (Research Report)
September 5, 1994... AUTHORS: V.S. Gallicchio, S. Kazini, E. Townsley, N.K. Hughes, K.F. Tse, K.F.W. Scott, J. Lin and N.J. Birch. University of Kentucky and Veterans Administration Medical Centers, Lexington, Kentucky; University of Wolverhampton,...

Relationship between infectious HIV-1 viral load, CD4 count and clinical status. (Research Report)
September 5, 1994... AUTHORS: J. Margolick, H. Farzadegan, D. Hoover, S. Rubb, E. Scott and A. Saah. Johns Hopkins University, Baltimore, Maryland. According to an abstract submitted by the authors to the X International AIDS Conference, held August 7-12,...

Long-term non-progressor. (Research Report)
September 5, 1994... AUTHORS: D.D. Ho. Aaron Diamond AIDS Research Center, New York, New York. According to an abstract submitted by the author to the X International AIDS Conference, held August 7-12, 1994, in Yokohama, Japan, "We have studied 10...

Host factors in the immunopathogenesis of human immunodeficiency virus (HIV) disease. (Research Report)
September 5, 1994... AUTHORS: A.S. Fauci. National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland. According to an abstract submitted by the author to the X International AIDS Conference, held August...

Using Markov processes to describe the prognosis of HIV-1 infection. (reprinted from Medical Decision Making, July-September 1994) (Periodical Report) (Abstract)
September 5, 1994... SOURCE: Medical Decision Making, July-September 1994;14(3):266-272. According to the authors' abstract of an article published in Medical Decision Making, "In 1989, Turner and colleagues proposed a new method for automated...

Oral atovaquone compared with intravenous pentamidine for Pneumocystic carinii pneumonia in patients with AIDS. (reprinted from the Annals of Internal Medicine, August 1, 1994) (Periodical Report) (Abstract)
September 5, 1994... SOURCE: Annals of Internal Medicine, August 1, 1994;121(3):174-180. According to the authors' abstract of an article published in Annals of Internal Medicine, "Objective: To test the hypothesis that the therapeutic success rate of...

Follicular dendritic cells retain HIV-1 particles on their plasma membrane, but are not productively infected in asymptomatic patients with follicular hyperplasia. (reprinted from the Journal of Immunology, August 1, 1994) (Periodical Report) (Abstract)
September 5, 1994... SOURCE: Journal of Immunology, August 1, 1994;153(3):1352-1359. According to the authors' abstract of an article published in the Journal of Immunology, "During HIV-1 infection, extensive alterations can be observed in the germinal...

Generation of antigen-specific CD8 CTLs from naive precursors. (reprinted from the Journal of Immunology, August 1, 1994) (Periodical Report) (Abstract)
September 5, 1994... SOURCE: Journal of Immunology, August 1, 1994;153(3):996-1003. According to the authors' abstract of an article published in the Journal of Immunology, "Class I MHC -restricted CTLs are an important component of the host immune...

Characterization of human CD4+, HIV-SF2 Nef-specific T-cell clones for antigen-processing and presentation requirements and for cytotoxic activity. (reprinted from Vaccine, August 1994) (Periodical Report) (Abstract)
September 5, 1994... SOURCE: Vaccine, August 1994;12(10):885-894. According to the authors' abstract of an article published in Vaccine, "We have described previously the generation of seven HIV-SF2 Nef-specific, CD4(+) T-cell clones, identification of...

Vaccine-induced antibodies to native and recombinant human immunodeficiency virus type 1 envelope glycoproteins. (reprinted from Vaccine, August 1994) (Periodical Report) (Abstract)
September 5, 1994... SOURCE: Vaccine, August 1994;12(10):912-918. According to the authors' abstract of an article published in Vaccine, "The ability of antibody induced by combination vaccination (human immunodeficiency virus type 1 (HIV-1-LAV) gp160...

X-ray crystallographic studies of a series of penicillin-derived asymmetric inhibitors of HIV-1 protease. (reprinted from Biochemistry, July 19, 1994) (Periodical Report) (Abstract)
September 5, 1994... SOURCE: Biochemistry, July 19, 1994;33(28):8417-8427. According to the authors' abstract of an article published in Biochemistry, "In the development of a treatment for AIDS, the HIV-1 protease has been identified as a good target...

Structural basis of asymmetry in the human immunodeficiency virus type 1 reverse transcriptase heterodimer. (reprinted from the Proceedings of the National Academy of Sciences of the United States of America, July 19, 1994) (Periodical Report) (Abstract)
September 5, 1994... SOURCE: Proceedings of the National Academy of Sciences of the United States of America, July 19, 1994;91(15):7242-7246. According to the authors' abstract of an article published in Proceedings of the National Academy of Sciences of...

Japan conference abstracts on CD-ROM for first time. (X International Conference on AIDS)
September 12, 1994... International For those interested in research presented in Japan at the X International Conference on AIDS, C.W. Henderson, Publisher, is making the conference abstracts available on CD-ROM for the first time. Topics include AIDS...

Vaccine created to generate HIV immune response. (HIV genes combined with poliovirus vaccine)
September 12, 1994... Industry News University of California, San Francisco (UCSF), researchers have inserted two HIV genes into the poliovirus vaccine to create a new, multi-purpose vaccine capable of generating an immune response in animals to HIV, the...

Will escape mutants doom envelope-based therapeutic HIV vaccines?
September 12, 1994... Therapeutic Vaccines Only very long clinical trials can determine the efficacy of therapeutic HIV vaccines, according to two leading clinical researchers. The long period between HIV infection and the development of clinical...

Whole inactivated virus vaccine ameliorates AIDS in monkeys.
September 12, 1994... HIV Vaccines Killed-virus vaccines might prolong survival in AIDS patients, an animal study suggests. The study showed that even though an inactivated simian immunodeficiency virus (SIV) vaccine failed to protect monkeys from SIV...

Crucial HIV peptide structure defined.
September 12, 1994... Antigen Structure The basic domain of the essential HIV*1 regulatory protein called Tat forms a stable alpha-helix in solution, University of California, San Francisco, researchers report. Many lentiviruses, including HIV*1, encode...

AIDS vaccine won't obviate need for behavior change, experts say.
September 12, 1994... HIV Vaccines It will take safe sex and other changes in behavior to bring AIDS under control and an overconfidence in a vaccine could even make the epidemic worse, several AIDS researchers warn. In a paper published in the journal...

NIH expands AIDS vaccine trials. (National Institutes of Health, National Institute of Allergy and Infectious Diseases)
September 12, 1994... Clinical Trials A five-year renewal of Vanderbilt University Medical Center's (VUMC), Nashville, Tennessee, grant to continue AIDS vaccine trials will allow testing of new and exciting approaches to vaccine production and delivery, a...

Grant awarded to develop HIV vaccine. (Apollon Inc.)
September 12, 1994... Funding Apollon Inc., Malvern, Pennsylvania, announced that it has received support from the U.S. National Institute of Allergy and Infectious Diseases (NIAID) of the U.S. National Institutes of Health through a grant to the University...

Testing gene therapy for AIDS.
September 12, 1994... Research In a step that may help doctors study gene therapy as an AIDS treatment, researchers reported for the first time successfully introducing genetically altered human immune cells into a mouse. The rodent provides the only...

Anti-HIV drug absorbed through skin in rats. (dideoxyinosine)
September 12, 1994... Treatment New research shows that a drug used to inhibit growth of HIV is absorbed through the skin in rats. If this also proves true in humans, the drug, dideoxyinosine (ddI), might be administered using a skin patch, said Jessie L.S....

Doctors seek Kaposi's sarcoma treatments.
September 12, 1994... Research Doctors who believe Kaposi's sarcoma (KS) has been neglected in the AIDS war are exploring new approaches toward the skin tumors. One of them, Dr. Steven A. Miles, a hematologist -oncologist at the University of California,...

Liposome Technology Inc. seeks U.S. marketing for DOX-SL. (anticancer product composed of doxorubicin hydrochloride and a Stealth liposome)
September 12, 1994... Industry News Liposome Technology Inc. (LTI), Menlo Park, California, announced that it has filed a New Drug Application (NDA) with the U.S. Food and Drug Administration (FDA) for its proprietary anticancer product DOX-SL. DOX-SL is...

Teams of scientists mobilized to advance AIDS therapies. (Strategic Program for Innovative Research on AIDS Treatment)
September 12, 1994... Development The U.S. National Institute of Allergy and Infectious Diseases (NIAID), has launched a new program to accelerate the development of innovative therapies to fight HIV infection. The new effort, called the Strategic...

Grant awarded for HIV diagnostic imaging scan. (Progenics Pharmaceuticals Inc.)
September 12, 1994... Development Progenics Pharmaceuticals Inc., Tarrytown, New York, announced it has been awarded $80,000 under Phase I of a Small Business Innovation Research Program (SBIR) grant by the U.S. National Institutes of Health. This funding is...

Grants awarded to study role of translation in viral diseases. (RiboGene Inc.)
September 12, 1994... Funding RiboGene Inc., Hayward, California, announced it has received three Small Business Innovative Research (SBIR) grants for Phase I feasibility studies to assist in developing new therapeutics based on translation - the process used...

Filter developed for viral inactivation of transfusion plasma. (HemaSure Inc.; ZLB Central Laboratory, Transfusion Service of the Swiss Red Cross)
September 12, 1994... Testing HemaSure Inc., Marlborough, Massachusetts, announced it is collaborating with ZLB Central Laboratory, Blood Transfusion Service of the Swiss Red Cross (ZLB), in Bern, Switzerland, to expedite development of HemaSure's LeukoVir...

Study validates quantitating viral load in whole blood. (of HIV virus)
September 12, 1994... HIV Culture Researchers from Belgium performed a study that validated the culture of unfractionated whole blood as a way to quantitatively assess the circulating HIV-1 load in infected children. Ariane Alimenti, University Hopital...

Suicide growing concern of gay teens.
September 12, 1994... Industry News An Oakland, California, woman will never forget the terrible heartache that came when the love for her son collided head-on with her deep-seated religious beliefs. She and her husband discovered that their son had...

Revised certification should clear way for new masks. (new guidelines for protective respirators)
September 12, 1994... NIOSH Revisions in the certification guidelines for protective respirators will clear the way for a new class of masks aimed at eliminating exposure to tuberculosis (TB) in the workplace, according to an official with the U.S. National...

Induction of cross-neutralizing antibodies and CTL by a chemically inactivated whole HIV vaccine. (Research Report)
September 12, 1994... Immunostimulant/Antiviral. Induction of Cross AUTHORS: E. Race, M.D. Addawe, P. Frezza and J.S. Oxford. London Hospital Medical College, London, United Kingdom; ISI, Naples, Italy. According to an abstract submitted by the authors...

Controlled release subunit vaccine for HIV-1. (Research Report)
September 12, 1994... AUTHORS: J.L. Cleland 1, M.F. Powell 1, A. Lim 1, L. Barron 1, P.W. Berman 1, J.H. Nunberg 1 and K.K. Murthy 2. 1Genentech, Inc, South San Francisco, California; 2SW Foundation Biomed Research, San Antonio, Texas. According to an...

AIDS institutes in Russia. (Research Report)
September 12, 1994... AUTHORS: V.V. Pokrovsky and O.P. Frolova. Russia AIDS Federal Center, Moscow, Russia. According to an abstract submitted by the authors to the X International AIDS Conference, held August 7-12, 1994, in Yokohama, Japan, "Objective: To...

A KAB survey in Metro Manila among dental, medical technology, and midwifery students. (knowledge of AIDS and HIV infection) (Research Report)
September 12, 1994... AUTHORS: J.A. Abaquin, M. Tan and N. Ortega. Health Action Information Network, Quezon City, Philippines. According to an abstract submitted by the authors to the X International Conference on AIDS, held August 7-12, 1994, in Yokohama,...

HIV/AIDS course for medical students. (at the Medical College of Ohio)
September 12, 1994... AUTHORS: J. Chakraborty 1, A. Purohit 2 and A. Gray 3. 1Medical College of Ohio; 2Harvard Deaconess Surgical Service; 3American Red Cross. According to an abstract submitted by the authors to the X International AIDS Conference, held...

Molecular characterization of a HIV-1 strain (HIV-1IbNg) from Nigeria.
September 12, 1994... AUTHORS: T.M. Howard and S. Rasheed. University of Southern California, Los Angeles, California. According to an abstract submitted by the authors to the X International AIDS Conference, held August 7-12, 1994, in Yokohama, Japan,...

A survey of university faculty regarding AIDS/HIV policy and inclusion of AIDS/HIV issues into curricula. (at Florida International University)
September 12, 1994... AUTHORS: R. Stempel, K. Arauz, V. Velez, C. White, J. Sandiford and R. Dollinger. Florida International University, Miami, Florida. According to an abstract submitted by the authors to the X International AIDS Conference, held August...

Anal intercourse and disclosure of HIV infection among seropositive gay and bisexual men. (reprinted from the Journal of Acquired Immune Deficiency Syndromes, August 1994) (Periodical Report) (Abstract)
September 12, 1994... SOURCE: Journal of Acquired Immune Deficiency Syndromes, August 1994;7(8):866-869. According to the authors' abstract of an article published in the Journal of Acquired Immune Deficiency Syndromes, "Human immunodeficiency virus...

Clinical and immunological correlates of immune-complex-dissociated HIV-1 p24 antigen in HIV-1 infected children. (reprinted from the Journal of Acquired Immune Deficiency Syndromes, August 1994) (Periodical Report) (Abstract)
September 12, 1994... SOURCE: Journal of Acquired Immune Deficiency Syndromes, August 1994;7(8):807-815. According to the authors' abstract of an article published in the Journal of Acquired Immune Deficiency Syndromes, "It has been reported that HIV-1...

Is HIV-1 likely to become a leading cause of adult Mortality in Sub-Saharan Africa? (reprinted from the Journal of Acquired Immune Deficiency Syndromes, August 1994) (Periodical Report) (Abstract)
September 12, 1994... SOURCE: Journal of Acquired Immune Deficiency Syndromes, August 1994;7(8):839-852. According to the authors' abstract of an article published in the Journal of Acquired Immune Deficiency Syndromes, "Concerns are sometimes expressed...

Effect of MTP-PE liposomes and interleukin-7 on induction of antibody and cell-mediated immune responses to a recombinant HIV-envelope protein. (muramyl tripeptide)(reprinted from the Journal of Acquired Immune Deficiency Syndromes, Aug, 1994)
September 12, 1994... SOURCE: Journal of Acquired Immune Deficiency Syndromes, August 1994;7(8):799-806. According to the authors' abstract of an article published in the Journal of Acquired Immune Deficiency Syndromes, "We investigated the ability of...

Surface expression of the HIV-1 envelope proteins in env gene-transfected CD4-positive human T-cell clones: characterization and killing by an antibody-dependent cellular cytotoxic mechanism. (reprinted from the Journal of Acquired Immune Deficiency Syndromes, August 1994) (Periodical Report) (Abstract)
September 12, 1994... SOURCE: Journal of Acquired Immune Deficiency Syndromes, August 1994;7(8):789-798. According to the authors' abstract of an article published in the Journal of Acquired Immune Deficiency Syndromes, "The env gene of the human...

Direct injection of a recombinant retroviral vector induces human immunodeficiency virus-specific immune responses in mice and nonhuman primates. (cytotoxic T-lymphocyte responses)(reprinted from the Journal of Virology, August 1994) (Periodical Report) (Abstract)
September 12, 1994... SOURCE: Journal of Virology, August 1994;68(8):5036 -5044. According to the authors' abstract of an article published in the Journal of Virology, "The cytotoxic T -lymphocyte (CTL) response plays an important role in controlling the...

Antibodies to pneumococcal capsular polysaccharides in children with human immunodeficiency virus infection given polyvalent pneumococcal vaccine. (reprinted from the Journal of Pediatrics, July 1994) (Periodical Report) (Abstract)
September 12, 1994... SOURCE: Journal of Pediatrics, July 1994;125(1):77-79. According to the authors' abstract of an article published in the Journal of Pediatrics, "Antibody to 7 common pneumococcal capsular polysaccharides was measured in 11 children...

Hepatitis B vaccination in infants of mothers infected with human immunodeficiency virus. (reprinted from the Journal of Pediatrics, July 1994) (Periodical Report) (Abstract)
September 12, 1994... SOURCE: Journal of Pediatrics, July 1994;125(1):70-72. According to the authors' abstract of an article published in the Journal of Pediatrics, "Eighteen infants of mothers with human immunodeficiency virus (HIV) infection were given...

Immunity to Haemophilus influenzae type B polysaccharide capsule in children with human immunodeficiency virus infection immunized with a single dose of Haemophilus vaccine. (reprinted from the Journal of Pediatrics, July 1994)(Periodical Report)
September 12, 1994... SOURCE: Journal of Pediatrics, July 1994;125(1):74-77. According to the authors' abstract of an article published in the Journal of Pediatrics, "We studied immunity to Haemophilus influenzae type b (Hib) polysaccharide capsule in 19...

Interleukin-12 (IL-12) augments cytolytic activity of natural killer cells toward Mycobacterium tuberculosis-infected human monocytes. (reprinted from Cellular Immunology, July 1994) (Periodical Report) (Abstract)
September 12, 1994... SOURCE: Cellular Immunology, July 1994;156(2):529-536. According to the author's abstract of an article published in Cellular Immunology, "We tested the impact of interleukin-12 (IL-12) and of cytotoxic leukocytes (particularly...

New AIDS drug stalled. (saquinavir)
September 19, 1994... Saquinavir An experimental drug awaited by AIDS patients won't be available outside limited clinical trials until at least the middle of 1995, its maker said. The disappointing news about Hoffman LaRoche's saquinavir came as AIDS...

Source case for 1991 prison outbreak refused treatment. (multidrug resistant tuberculosis)
September 19, 1994... TB Outbreaks The source case for a widely reported multidrug resistant tuberculosis (MDR-TB) outbreak in an upstate New York prison lived in the general prison population while infectious and refused treatment, according to a report from...

Less deadly HIV-2 may yield clues for preventing AIDS.
September 19, 1994... International The virus known as HIV-2 causes AIDS much less frequently than the HIV-1 strain found in the United States, researchers have found from a years-long study of prostitutes in Senegal. By searching for the reasons,...

Small molecule drugs to inhibit pathologic programmed cell death. (apoptosis)
September 19, 1994... Research Receptagen, Vancouver, British Columbia, announced the signing of an agreement to expand the scope of research on drugs to regulate apoptosis, or pre -programmed cellular suicide, with the Institute for Biological Sciences of...

AIDS growing among minorities.
September 19, 1994... Case Rates Minorities are being hit increasingly harder by AIDS, accounting for more than half of all new cases in the United States in 1993. Of the 106,949 AIDS cases reported in 1993 in the United States, Puerto Rico, Guam and the...

Group wins grant to battle AIDS spread among Hispanic women. (Mujeres Project Inc.)
September 19, 1994... Funding A group to fight the spread of AIDS among Hispanic women announced it will develop an outreach program in South Texas through a $85,000 grant from the Levi Strauss Foundation. "It is time to destroy the myth that women do...

Award received to lead team for HIV research. (National Institute of Allergy and Infectious Diseases award to Fred Hutchinson Cancer Research Center and University of Washington researchers)
September 19, 1994... HIV Research The U.S. National Institute of Allergy and Infectious Diseases (NIAID) has awarded nearly $1 million for the initial phase of a four-year study to develop and test strategies for the treatment of HIV infection. Drs....

Former Surgeon General sees no cure for AIDS. (C. Everett Koop)
September 19, 1994... Controversy Former U.S. Surgeon General C. Everett Koop is pessimistic about the prospects of science finding a way to curb the spread of AIDS. "There never will be a cure, and the likelihood of a vaccine is dim," Koop told an...

HIV testing for football players, health workers. (Australia)
September 19, 1994... Australia In Australia, football players and healthcare professionals face new HIV infection control guidelines, according to reporter Christopher Zinn. The controversial guidelines are, in effect, compulsory testing, Zinn...

AIDS Action executive director Daniel T. Bross to resign. (Aids Action Council, AIDS Action Foundation)
September 19, 1994... Industry News Two days after AIDS Action marked its tenth anniversary as the leading national advocate for effective federal AIDS policies, Daniel T. Bross, executive director of AIDS Action Council and administrator of the council's...

Sites awarded for community-based AIDS trials.
September 19, 1994... Clinical Trials Community-based physicians will study promising HIV therapies at four new sites joining the community-based clinical trials network supported by the U.S. National Institute of Allergy and Infectious Diseases (NIAID). ...

HIV is inactivated in platelet suspensions by AMT and UVA. (aminomethyltrimethylpsoralen, ultraviolet-A light)
September 19, 1994... Virus Inactivation Aminomethyltrimethylpsoralen (AMT) plus ultraviolet light (UVA) is an effective way to inactivate free and cell-associated HIV in platelet suspensions, indicated researchers from the American Red Cross, Rockville,...