AIDS Weekly articles from October 1995

AIDS Weekly archives from October 1995

ACTG 175: first line AIDS therapy should be combination.(a clinical trial)
October 2, 1995... The newly-released results of a major AIDS clinical trial support changing the first-line therapy for people with HIV infection. Instead of monotherapy with zidovudine (AZT), the study shows that patients benefit more from combination therapy...

Abbott protease inhibitor shines in combinations.
October 2, 1995... The HIV protease inhibitor ritonavir (ABT-538) nearly obliterated HIV in some patients who took the drug in combination with two standard AIDS therapies. Moreover, animal studies show that ritonavir in combination with another protease...

Very-high-dose saquinavir highly effective.
October 2, 1995... Very high doses of the HIV protease inhibitor saquinavir (manufactured by Hoffmann-La Roche, Nutley, New Jersey) have a profound antiviral effect in people with intermediate-stage HIV disease. Saquinavir, also known as Ro 31-8959 or Invirase,...

CDC says black/Hispanic gays in US at greater HIV risk.(Centers for Disease Control and Prevention)
October 2, 1995... African American and Hispanic gay and bisexual men in the United States continue to have a greater risk of contracting HIV than their white counterparts, according to a report from the University of Washington and the U.S. Centers for Disease...

C'-ADE understanding may assist HIV vaccine development.(complement-mediated, antibody-dependent enhancement)
October 2, 1995... Complement-mediated, antibody-dependent enhancement (C'-ADE) activity is one of the earliest humoral immune responses to simian immunodeficiency virus (SIV) infection in macaques, according to a report from Durham, North Carolina's Duke...

Two poxviruses offer HIV protection in macaques.
October 2, 1995... Two highly attenuated HIV-2 recombinant poxviruses induced long-lasting protection against HIV in a rhesus macaque study conducted through the U.S. National Institutes of Health's Division of AIDS. Several HIV vaccine candidates have been found...

African HIV+ at increased risk for shingles.
October 2, 1995... People born in Africa who become HIV positive are at greater risk of developing shingles than those born in non-tropical regions, according to a report from the United Kingdom. The report was presented by David A. Lewis and colleagues at the...

Syphilis outbreak coincides with HIV increase.
October 2, 1995... An epidemic of syphilis occurring in Houston, Texas in the early 1990s coincided with an increase in HIV infection among adolescent African American women in that area, according to a report from the Texas Health and Human Services Department and...

Immunization with HIV-IT(V) stimulates HIV-1 specific CTLS.(retroviral vector with HIV IIIB env/rev genes, cytotoxic T-lymphocytes)
October 2, 1995... Immunotherapy in HIV(+) patients with a retroviral vector encoding the HIV IIIB env/rev genes [HIV-IT(V)] stimulated HIV-1 specific cytotoxic T-lymphocytes (CTLs). J. Merritt et al. from Viagene, Inc., San Diego, California and Shared Medical...

Sleep distortion common in asymptomatic HIV+.
October 2, 1995... Asymptomatic HIV positive persons with CD4 counts of more than 400x10(6)/L show a statistically significant increase in slow-wave sleep during the latter part of the night and are slower to arouse, according to a report from a noted sleep...

Study suggests drug reduces mortality of patients with advanced AIDS.
October 2, 1995... The antibiotic clarithromycin has proven to prolong life in patients with advanced HIV infection by disseminated Mycobacterium avium complex (MAC), researchers reported at the 35th Interscience Conference on Antimicrobial Agents and Chemotherapy,...

Supplemental nutrients may slow HIV progression.
October 2, 1995... Micronutrient deficiencies appear to be associated with HIV-1 disease progression, suggesting that supplemental nutrient replacement may be more important than previously thought. It has long been recognized that AIDS patients exhibit...

Stavudine efficacy compared to zidovudine in ZDV-pretreated HIV positive patient.(zidovudine)
October 2, 1995... Switching to stavudine (also known as d4T, brand name Zerit) was more effective than continuing zidovudine (also known as AZT, brand name Retrovir) at preventing progression to AIDS or death among patients with HIV who had been taking zidovudine...

Jury still out on spermicide use for stopping HIV.
October 2, 1995... It is still not clear whether the use of spermicides during sex reduces the risk of HIV transmission, and some studies suggest that their use may actually increase such risks. This was the conclusion from a review of the literature presented at...

Male-to-female HIV risk far greater than female-to-male.
October 2, 1995... Almost 20 percent of the female sex partners of HIV infected males in a California study also became HIV positive during the study period, compared to just 2 percent of male partners of females who were infected. The University of California...

Cytokine-containing liposome may be adjuvant HIV vaccine.
October 2, 1995... The induction of delayed-type hypersensitivity (DTH) through vaccination may increase protection from viral pathogens such as HIV, suggesting that cytokine-containing liposomes may be an effective adjuvant for the induction of a DTH response to...

Quantitation of simian immunodeficiency virus (SIV) RNA in plasma of acute and chronically infected rhesus macaques using a branched DNA (bDNA) signal amplification assay.(Research Report)
October 2, 1995... According to an abstract submitted by the author to the 35th Interscience Conference on Antimicrobial Agents and Chemotherapy, sponsored by the American Society for Microbiology, held September 17-20, 1995, in San Francisco, California,...

Detection of herpesvirus-like agent (KSHV) in classic and epidemic AIDS Kaposi's sarcoma by in situ hybridization.(Research Report)
October 2, 1995... According to an abstract submitted by the author to the 35th Interscience Conference on Antimicrobial Agents and Chemotherapy, sponsored by the American Society for Microbiology, held September 17-20, 1995, in San Francisco, California, "Kaposi's...

Detection of Kaposi's sarcoma-associated herpesvirus (KSHV) and cytomegalovirus (CMV) in semen of men with HIV infection.(Research Report)
October 2, 1995... According to an abstract submitted by the author to the 35th Interscience Conference on Antimicrobial Agents and Chemotherapy, sponsored by the American Society for Microbiology, held September 17-20, 1995, in San Francisco, California,...

Current trends in epidemiology of Kaposi's sarcoma.(Research Report)
October 2, 1995... According to an abstract submitted by the author to the 35th Interscience Conference on Antimicrobial Agents and Chemotherapy, sponsored by the American Society for Microbiology, held September 17-20, 1995, in San Francisco, California,...

HIV-IT (V) stimulates HIV-1 specific cytotoxic T-lymphocytes following intramuscular administration to HIV seropositive volunteers.(HIV(IIIB) env/rev encoding retroviral vector)(Research Report)
October 2, 1995... According to an abstract submitted by the author to the 35th Interscience Conference on Antimicrobial Agents and Chemotherapy, sponsored by the American Society for Microbiology, held September 17-20, 1995, in San Francisco, California, "We...

Phase I study of an HIV(IIIB) env/rev encoding retroviral vector (HIV-IT-V) in HIV seropositive patients with CD4 greater than or equal to 200.(Research Report)
October 2, 1995... According to an abstract submitted by the author to the 35th Interscience Conference on Antimicrobial Agents and Chemotherapy, sponsored by the American Society for Microbiology, held September 17-20, 1995, in San Francisco, California,...

Simultaneous transmission of both human immunodeficiency virus (HIV) and hepatitis C virus (HCV) with delayed seroconversion in a healthcare worker (HCW).(Research Report)
October 2, 1995... According to an abstract submitted by the author to the 35th Interscience Conference on Antimicrobial Agents and Chemotherapy, sponsored by the American Society for Microbiology, held September 17-20, 1995, in San Francisco, California,...

Tuberculosis after isoniazid chemoprophylaxis in HIV infected patients: a warning for isoniazid resistance.(Research Report)
October 2, 1995... According to an abstract submitted by the author to the 35th Interscience Conference on Antimicrobial Agents and Chemotherapy, sponsored by the American Society for Microbiology, held September 17-20, 1995, in San Francisco, California,...

Use of antiherpes drugs and the risk of Kaposi's sarcoma.(Research Report)
October 2, 1995... According to an abstract submitted by the author to the 35th Interscience Conference on Antimicrobial Agents and Chemotherapy, sponsored by the American Society for Microbiology, held September 17-20, 1995, in San Francisco, California, "Because...

Mother-to-infant transmission of hepatitis C in children born to mothers coinfected with HIV and HCV.(Research Report)
October 2, 1995... According to an abstract submitted by the author to the 35th Interscience Conference on Antimicrobial Agents and Chemotherapy, sponsored by the American Society for Microbiology, held September 17-20, 1995, in San Francisco, California, "Among...

Detection of human immunodeficiency virus (HIV) type 1 antibodies by new automated microparticle enzyme immunoassay for HIV types 1 and 2.(reprinted from Journal of Clinical Microbiology, September 1995)(Periodical Report)(Abstract)
October 2, 1995... According to the authors' abstract of an article published in Journal of Clinical Microbiology, "We compared an automated microparticle double-antigen sandwich enzyme Immunoassay (EIA) for the IMx test system recently developed by Abbott with two...

Early diagnosis of HIV-1 infection in infants in Dar es Salaam, Tanzania.(reprinted from Clinical and Diagnostic Virology, August 1995)(Periodical Report)(Abstract)
October 2, 1995... According to the authors' abstract of an article published in Clinical and Diagnostic Virology, "OBJECTIVES: To evaluate two simple methods, an immune complex dissociation (ICD) p24 antigen assay and an HIV-1-specific IgA antibody assay, for the...

Temporal trends in human immunodeficiency virus seroprevalence and sexual behavior at the San Francisco municipal sexually transmitted disease clinic, 1989-1992.(reprinted from American Journal of Epidemiology, August 1, 1995)(Periodical Report)(Abstract)
October 2, 1995... According to the authors' abstract of an article published in American Journal of Epidemiology, "The authors analyzed temporal trends in human immunodeficiency virus (HIV) infection among men and women who visited the San Francisco municipal...

Defective natural immunity: an early manifestation of human immunodeficiency virus infection.(reprinted from Journal of Experimental Medicine, September 1, 1995)(Periodical Report)(Abstract)
October 2, 1995... According to the authors' abstract of an article published in Journal of Experimental Medicine, "Cytotoxicity mediated by natural killer (NK) and lymphokine-activated killer (LAK) cells may be of significance in host defense against viral...

Couple communication, sexual coercion and HIV risk reduction in Kigali, Rwanda.(reprinted from AIDS, August 1995)(Periodical Report)(Abstract)
October 2, 1995... According to the authors' abstract of an article published in AIDS, "OBJECTIVES: To describe sexual interaction and HIV-related communication in Rwandan couples and to examine their relationship to HIV testing and condom use. STUDY DESIGN:...

A community trial of the impact of improved sexually transmitted disease treatment on the HIV epidemic in rural Tanzania.1. design.(reprinted from AIDS, August 1995)(Periodical Report)(Abstract)
October 2, 1995... According to the authors' abstract of an article published in AIDS, "OBJECTIVE: To describe the rationale and design of a randomized trial of the impact of improved services for the treatment of sexually transmitted diseases (STD) on the...

Correlation between AIDS-related Kaposi's sarcoma histological grade and in vitro behavior: KS reduced exogenous growth factor requirements for isolates from high grade lesions.(reprinted from Lymphology, September 1995)(Periodical Report)(Abstract)
October 2, 1995... According to the authors' abstract of an article published in Lymphology, "Kaposi's sarcoma, the most common AIDS associated malignancy, affects 10-30% of all AIDS patients. To date, research into the biological characteristics of AIDS-related...

Intermittent shedding of human immunodeficiency virus in semen: implications for sexual transmission.(reprinted from Journal of Urology, September 1995)(Periodical Report)(Abstract)
October 2, 1995... According to the authors' abstract of an article published in Journal of Urology, "PURPOSE: We attempt to increase our understanding of human immunodeficiency virus (HIV) shedding in semen. MATERIALS AND METHODS: We followed 16 seropositive men...

Natural selection of the gag, pol, and env genes of human immunodeficiency virus 1 (HIV-1).(reprinted from Molecular Biology and Evolution, September 1995)(Periodical Report)(Abstract)
October 2, 1995... According to the authors' abstract of an article published in Molecular Biology and Evolution, "Natural selection on polymorphic protein-coding loci of human immunodeficiency virus-1 (HIV-1), the more geographically widespread of the two viruses...

Drug-resistant HIV mutants exist before drug therapy begins.
October 9, 1995... No matter how effective an anti-HIV drug may be, it can never prevent the appearance of drug-resistant mutants - because such mutants already exist. According to retrovirologist John Coffin of Tufts University School of Medicine, Boston,...

HIV crossed species barrier from monkeys to humans.
October 9, 1995... Both HIV-1 and HIV-2 jumped the species barrier from monkeys to humans - and it could happen again. These monkey-to-human transmissions of what would become the AIDS viruses occurred not once but at least twice in the case of HIV-1 and at...

HO: "Raging fire" destroys CD4 cells.(AIDS researcher David D. Ho describes HIV infection)
October 9, 1995... The raging fire of HIV infection burns up a person's CD4(+) T cells and causes AIDS, according to David D. Ho, director of New York's Aaron Diamond AIDS Research Center. As a consequence, Ho strongly favors very early antiretroviral therapy -...

MACS study supports new theories of AIDS pathogenesis.(Multicenter AIDS Cohort Study)
October 9, 1995... AIDS is the result of extensive HIV replication and is not caused by antigenic exhaustion or self-destruction of the immune system, clinical data suggest. The loss of CD4(+) T lymphocytes that characterizes AIDS is a phenomenon that...

Lifelong TB prophylaxis may be needed in endemic areas.(tuberculosis)
October 9, 1995... The value of fixed-duration tuberculosis preventive therapy may be limited in developing areas where TB is endemic, according to an official with the World Health Organization (WHO). Richard O'Brien of WHO's Global TB Program said this is...

Woman injected with HIV by ex-lover.
October 9, 1995... A woman in The Netherlands who was forcibly injected with HIV tainted blood by a former lover had symptomatic AIDS within six months of exposure. In 1993 the woman was injected with between 2- to 5-mL of blood from a third person who had...

Combined therapy with IFN-alpha not better than AZT alone.(interferon)
October 9, 1995... A large scale European study suggests that combination therapy with low dose lymphoblastoid interferon-alpha and zidovudine is not superior to monotherapy with zidovudine alone. Interferon (IFN)-(alpha) has been shown to inhibit HIV replication...

PCR generally accurate weeks after birth.(polymerase chain reaction)
October 9, 1995... The sensitivity of polymerase chain reaction (PRC) HIV testing in newborns is higher than previously reported, suggesting that a negative test soon after birth is of diagnostic significance. Negative PCR results are often seen in neonates...

IL-7 may be important in future immune-based therapies.(interleukin, AIDS therapies)
October 9, 1995... Interleukin-7 (IL-7) may be important in future immune-based therapies involving large scale antigen-specific effector cell activation/expansion, according to a report from Durham, North Carolina's Duke University. CD8(+) cytotoxic T...

Route of delivery may be critical.(delivery of HIV vaccine)
October 9, 1995... The route of immunization may be critical to the efficacy of a HIV vaccine, according to report from the United Kingdom. The four major routes of HIV transmission - rectal, vaginal, male genital and intravenous - have been the subject of...

STD treatment reduces HIV in rural Tanzania.(sexually transmitted disease)
October 9, 1995... Improved sexually transmitted disease (STD) treatment reduced HIV infection by about 40 percent in a rural population in Tanzania. "Although a few evaluation studies have been published, these have been observational in design, and this is the...

Controversy erupts in Brazil over penis nicknames.
October 9, 1995... A controversial anti-AIDS campaign in Brazil, which dubbed the penis "Braulio" - a common men's name - has revealed the existence of such a long list of names given to the masculine genital organ that an entire dictionary could be published....

Programs have nearly doubled in number since 1993.(needle exchange programs in US)
October 9, 1995... The number of needle exchange programs (NEPs) operating in the United States today has nearly doubled since 1993, according to a new report co-authored by a University of California, San Francisco (UCSF) AIDS researcher. Appearing in the...

Intermittent HIV shedding has transmission implications.(presence of virus in semen)
October 9, 1995... The determination that HIV is shed intermittently in semen has implications for sexual transmission of the virus, according to a report from New York University School of Medicine. In earlier studies researcher John N. Krieger and colleagues...

Shalala names Dr. Helene Gayle to head office of AIDS, STDS, TB.(US Health and Human Services Secretary, Donna Shalala, sexually transmitted diseases, tuberculosis)
October 9, 1995... A scientist who has studied AIDS in women and children has been named director of the government's new centralized office for AIDS. Dr. Helene D. Gayle was appointed to the post September 21, 1995 at CDC by U.S. Health and Human Services...

Researchers identify disease-fighting gene.(in HIV that stops CD4 T-cell production)
October 9, 1995... Researchers report they have identified a gene within HIV that stops production of the CD4 T-lymphocyte cells. Researchers hoped the discovery could eventually lead to new AIDS therapies that block the gene's action and allow immune cells to...

Acid fast bacilli on direct respiratory tract specimens of HIV infected patients: Mycobacterium tuberculosis or Mycobacterium avium?(Research Report)
October 9, 1995... According to an abstract submitted by the author to the 35th Interscience Conference on Antimicrobial Agents and Chemotherapy, sponsored by the American Society for Microbiology, held September 17-20, 1995, in San Francisco, California,...

A prospective study of human papillomavirus (HPV) genotypes associated with persons infected with HIV.(Research Report)
October 9, 1995... According to an abstract submitted by the author to the 35th Interscience Conference on Antimicrobial Agents and Chemotherapy, sponsored by the American Society for Microbiology, held September 17-20, 1995, in San Francisco, California,...

Massive pleural effusion (MPE) as presenting manifestation of cryptococcosis in AIDS patients.(Research Report)
October 9, 1995... According to an abstract submitted by the author to the 35th Interscience Conference on Antimicrobial Agents and Chemotherapy, sponsored by the American Society for Microbiology, held September 17-20, 1995, in San Francisco, California, "AIDS...

Non-Hodgkin's lymphoma (NHL) and AIDS: experience of two referral centers in Mexico City.(Research Report)
October 9, 1995... According to an abstract submitted by the author to the 35th Interscience Conference on Antimicrobial Agents and Chemotherapy, sponsored by the American Society for Microbiology, held September 17-20, 1995, in San Francisco, California,...

Antisense oligonucleotide safety and efficacy for CMV retinitis in AIDS patients.(cytomegalovirus)(Research Report)
October 9, 1995... According to an abstract submitted by the author to the 35th Interscience Conference on Antimicrobial Agents and Chemotherapy, sponsored by the American Society for Microbiology, held September 17-20, 1995, in San Francisco, California, "ISIS...

Evaluation of the pharmacokinetics and safety of single and multiple high dose regimens of levofloxacin in HIV seropositive subjects.(Research Report)
October 9, 1995... According to an abstract submitted by the author to the 35th Interscience Conference on Antimicrobial Agents and Chemotherapy, sponsored by the American Society for Microbiology, held September 17-20, 1995, in San Francisco, California,...

Strong HIV-1 inhibitory activity by antisense phosphorothioate oligonucleotides (AS S-ODN) targeted to HIV-1 untranslated leader sequences.(Research Report)
October 9, 1995... According to an abstract submitted by the author to the 35th Interscience Conference on Antimicrobial Agents and Chemotherapy, sponsored by the American Society for Microbiology, held September 17-20, 1995, in San Francisco, California, "AS...

Transfusion associated AIDS cases (TAAC) in Mexico, epidemiological profile and incubation period.(Research Report)
October 9, 1995... According to an abstract submitted by the author to the 35th Interscience Conference on Antimicrobial Agents and Chemotherapy, sponsored by the American Society for Microbiology, held September 17-20, 1995, in San Francisco, California, "An...

Natural history of HIV disease in children with less than 100 CD4 lymphocytes.(Research Report)
October 9, 1995... According to an abstract submitted by the author to the 35th Interscience Conference on Antimicrobial Agents and Chemotherapy, sponsored by the American Society for Microbiology, held September 17-20, 1995, in San Francisco, California,...

Modified antisense oligodeoxynucleotides against the splice acceptor site of tat do not inhibit in vitro hematopoietic colony growth in HIV-positive patients.(reprinted from Annals of Hematology, August 1995)(Periodical Report)(Abstract)
October 9, 1995... According to the authors' abstract of an article published in Annals of Hematology, "The hematopoietic failure in the majority of patients with progressive HIV infection is further aggravated by virustatic agents like azidothymidine. As an...

Rapid and simple purification of human immunodeficiency virus type 1 epitope p24 and its use in ELISA.(enzyme-linked immunosorbent assay)(reprinted from Molecules and Cells, August 31, 1995)(Periodical Report)(Abstract)
October 9, 1995... According to the authors' abstract of an article published in Molecules and Cells, "In order to develop a reliable and inexpensive serodiagnostic method, gag protein of human immunodeficiency virus type 1 (HIV-1), p24 (HIV-gag; bp 730-1419) was...

In-vitro and intracellular activity of rifabutin on drug-susceptible and multiple drug-resistant (MDR) tubercle bacilli.(reprinted from Journal of Antimicrobial Chemotherapy, August 1995)(Periodical Report)(Abstract)
October 9, 1995... According to the authors' abstract of an article published in Journal of Antimicrobial Chemotherapy, "Rifabutin, a spiropiperidyl derivative of rifampicin, is approved for the prophylaxis of Mycobacterium avium infections in AIDS patients in the...

A vaccinia-gp160-based vaccine but not a gp160 protein vaccine elicits anti-gp 160 cytotoxic T lymphocytes in some HIV-1 seronegative vaccinees.(reprinted from Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, September 1, 1995)(Periodical Report)(Abstract)
October 9, 1995... According to the authors' abstract of an article published in Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, "Cytotoxic T lymphocytes (CTL) play an important role in the immune response to viral infection by recognizing...

Impact of MHC class I gene on resistance to murine AIDS.(major histocompatibility complex)(reprinted from Scandinavian Journal of Immunology, September 1995)(Periodical Report)(Abstract)
October 9, 1995... According to the authors' abstract of an article published in Scandinavian Journal of Immunology, "Development of murine AIDS in mice following infection with LP-BM5 murine leukaemia virus (MuLV) is highly strain dependent, with strain...

Photodynamic therapy in AIDS-related cutaneous Kaposi's sarcoma.(reprinted from Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, September 1, 1995)(Periodical Report)(Abstract)
October 9, 1995... According to the authors' abstract of an article published in Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, "For evaluating the role of photodynamic therapy (PDT) in the local treatment of acquired immune deficiency...

Adenovirus infections in human immunodeficiency virus-positive patients: clinical features and molecular epidemiology.(reprinted from Journal of Infectious Diseases, September 1995)(Periodical Report)(Abstract)
October 9, 1995... According to the authors' abstract of an article published in Journal of Infectious Diseases, "Prospective surveillance of 63 human immunodeficiency virus (HIV)-positive patients and 9 HIV-negative partners over 5-27 months yielded 51...

The effect of infection with human immunodeficiency virus on anticryptococcal activity of lymphocytes and monocytes.(reprinted from Journal of Infectious Diseases, September 1995)(Periodical Report)(Abstract)
October 9, 1995... According to the authors' abstract of an article published in Journal of Infectious Diseases, "The effect of infection with human immunodeficiency virus (HIV) on the capacity of human lymphocytes and monocytes to inhibit and kill Cryptococcus...

Antiviral effects of foscarnet and ganciclovir therapy on human immunodeficiency virus p24 antigen in patients with AIDS and cytomegalovirus retinitis.(reprinted from Journal of Infectious Diseases, September 1995)(Periodical Report)(Abstract)
October 9, 1995... According to the authors' abstract of an article published in Journal of Infectious Diseases, "To examine whether the prolonged survival seen in patients treated with foscarnet compared with those treated with ganciclovir was due to a direct...

Lower survival in AIDS patients receiving dapsone compared with aerosolized pentamidine for secondary prophylaxis of Pneumocystis carinii pneumonia.(reprinted from Journal of Infectious Diseases, September 1995)(Periodical Report)(Abstract)
October 9, 1995... According to the authors' abstract of an article published in Journal of Infectious Diseases, "A randomized, unblinded study compared aerosolized pentamidine, 300 mg every month, and dapsone, 50 mg/day, for secondary prophylaxis of pneumocystosis...

Comparison of human immunodeficiency virus biological phenotypes isolated from cerebrospinal fluid and peripheral bleed.(reprinted from Journal of Medical Virology, September 1995)(Periodical Report)(Abstract)
October 9, 1995... According to the authors' abstract of an article published in Journal of Medical Virology, "Quantitative human immunodeficiency virus (HIV) cultures were carried out on cerebrospinal fluid (CSF), peripheral blood mononuclear cells (PBMCs), and...

"Robust" anti-HIV activity in AG1343 trial. (HIV protease inhibitor)
October 16, 1995... The promising new HIV protease inhibitor AG1343 is effective and well tolerated at all doses studied in Phase II clinical trials. The drug, developed by Agouron Pharmaceuticals and Japan Tobacco Inc. under the trade name Viracept, has been the...

Indinavir sulfate plus AZT equals sustained decline in HIV.
October 16, 1995... The powerful anti-HIV effects of the Merck protease inhibitor indinavir sulfate are sustained when it is administered in combination with zidovudine (AZT). Indinavir sulfate (MK-639, formerly L-735,524 or L-524, trade name Crixivan), is one...

New evidence strengthens HHV-8 link to KS. (herpesvirus, Kaposi's sarcoma)
October 16, 1995... The novel herpesvirus associated with Kaposi's sarcoma (KS) can be detected in the nuclei of the cells associated with the tumor. In 1994, Columbia University researchers Yuan Chang and colleagues reported finding DNA from a new herpesvirus in...

Specific herpesvirus associated with KS. (Kaposi's sarcoma)
October 16, 1995... The presence of Kaposi's sarcoma-associated herpesvirus in the blood of HIV infected patients with the opportunistic infection is further evidence of its causative role, according to a report from the United Kingdom. It has long been believed...

Missed TB opportunities frequent among poor. (tuberculosis prevention)
October 16, 1995... Opportunities within the public health system for tuberculosis prevention among the poor and disenfranchised have repeatedly been missed, according to a report from Emory University, Atlanta, Georgia. The report found that correctional...

Rifampin resistance growing in HIV+ TB patients. (tuberculosis)
October 16, 1995... Rifampin-resistance appears to be a growing problem among HIV infected patients with tuberculosis, according to a U.S. Centers for Disease Control and Prevention (CDC) report. The CDC report is based on a review of rifampin-resistant TB cases...

15,000 kids in U.S. infected by their mothers. (HIV infection transmission)
October 16, 1995... Roughly 15,000 children in the United States had been prenatally infected with HIV by 1994, and about 12,000 were still alive, according to the U.S. Centers for Disease Control and Prevention (CDC). "We estimate that from 1978 through 1993,...

Inhibition of HIV production: clinical implications.
October 16, 1995... Sequence-specific inhibition of HIV reverse transcription by antisense oligonucleotides suggests future clinical applications. Oligonucleotides can be used to control viral genome expression. Two methods can be used in order to specifically...

Minority groups/young gay men have high and worsening rates of HIV.
October 16, 1995... African Americans and Latinos account for a disproportionately large share of people with AIDS, and high rates of new infections continue among younger gay and bisexual men of all ethnic groups, according to UCSF researchers who contributed to a...

Syncytium phenotype lower in IV drug users.
October 16, 1995... The prevalence of syncytium-inducing phenotype, associated with accelerated CD4 decline and AIDS progression, is much lower among intravenous drug users with HIV infection than among infected homosexuals. There is increasing research...

TB, HIV and hepatitis test results announced. (tuberculosis)(California Department of Corrections screening of inmates)
October 16, 1995... The California Department of Corrections announced the results of two unique studies: * A system-wide tuberculosis (TB) screening of inmates and employees; and * A seroprevalence study of 5,000 incoming inmates for HIV and hepatitis. "We...

Determining V3 response may be crucial. (third variable in HIV virus reproduction)
October 16, 1995... Characterization of individual immune responses followed by selective immunization with highly immunogenic constructs may be critical to the development of successful vaccine strategies against HIV. HIV-1 has a very high rate of mutation,...

Decline in HIV reported among young males in Thailand.
October 16, 1995... A decline in HIV prevalence among young males in Thailand suggests that AIDS prevention programs in that country are working. In the late 1980s and early 1990s there was a dramatic rise in HIV infections in Thailand. To monitor the epidemic...