AIDS Weekly articles from October 1994

AIDS Weekly archives from October 1994

New options for treatment of AIDS cachexia.
October 3, 1994... The most striking feature of late-stage HIV disease is the alarming wasting seen in more than half of all patients. This complex process of severe protein energy malnutrition leading to extre me involuntary weight loss is often fatal...

HIV test sensitivity for HIV-1 subtype 0.
October 3, 1994... International Murex Technologies Corporation (Murex), Atlanta, Georgia, ann ounced the launch of its enhanced HIV blood screening test. The modified product is based on Murex's existing Wellcozyme HIV 1+2 test, which is one of the largest...

Multiple CMV strains associated with progression. (cytomegalovirus)
October 3, 1994... The presence of multiple cytomegalovirus (CMV) strains in human immunodefic iency virus-1 (HIV-1)-positive homosexual men is associated with progression to AIDS, possibly through activation of HIV-1-infected CD4 cells, according to a report...

Gene governs development of all the body's defenses. (transcription factor PU-1)
October 3, 1994... A regulatory gene known to be active in cells of the blood-forming tissues is in fact the key control governing the formation of all the different cells of the immune sys tem and the infection-fighting cells of the blood, researchers at the...

WHO says Indian AIDS funds misused. (World Health Organization)
October 3, 1994... Funds provided to India to promote AIDS awareness have been misused, in som e instances by truck drivers who use freely distributed condoms to plug leaking ra diators, the World Health Organization (WHO) said. A WHO report said...

Cationized immunoglobulins used to treat HIV lymphocytes.
October 3, 1994... Cationization of human immunoglobulin preparations, such as HIV-immunoglobu lins (HIVIG) and intravenous immunoglobulins (IVIG) increases the endocytosis of immu noglobulin and the inhibition of HIV-1 replication in human peripheral blood...

Condom campaign heralds arrival of weapon against AIDS.
October 3, 1994... Wisconsin Pharmacal's, New York, Female Health Company announced plans for the consumer and professional launch of the Reality female condom at a press confere nce in New York. The revolutionary contraceptive is the only product a woman can...

Women's risks rise with partners. (of contracting AIDS)
October 3, 1994... College women neglect condoms more often and engage in riskier sexual activ ity as they increase their number of sex partners, University of Michigan (UM) researchers s aid. Researchers at UM's School of Public health said their...

Experimental treatment access for women with HIV demanded.
October 3, 1994... The Rev. James H. Littrell, Executive Director of the Philadelphia AIDS Con sortium, announced the Consortium's full support for a list of demands that will be prese nted to the U.S. Food and Drug Administration (FDA) in Rockville, Maryland....

Cervical ectopy may increase susceptibility to HIV-1.
October 3, 1994... Cervical ectopy and pelvic inflammatory disease may increase susceptibility to HIV-1 in women with genital ulcers, according to a report from the World Health Organizat ion published in the August 1994 issue of the Journal of Infectious...

Water free of Cryptosporidium. (Detroit, Michigan)
October 3, 1994... The following was released by the Detroit, Michigan, Water and Sewerage Dep artment (DWSD): The NBC "Dateline" TV news magazine featured three segments on water qualit y on September 20-23, 1994. The focus of the September 20, 1994,...

Test released for treating cryptosporidiosis. (Biomune Systems Inc.'s Immuno-C)
October 3, 1994... Biomune Systems Inc., Salt Lake City, Utah, announced the results from inde pendent laboratory tests using a recently developed in vitro test that demonstrated the effectiveness of Biomune's drug, Immuno-C, against the parasite that causes...

Prevention of disease the answer. (Rwanda)
October 3, 1994... The director general of the World Health Organization (WHO) says he conside rs control of epidemics a priority in war-torn Rwanda. In an interview following a two-day visit to the Central African state, Hir oshi Nakajima stressed the...

Dental chain pays $100,000 to settle HIV case. (Castle Dental Center Inc.)
October 3, 1994... A Houston, Texas, dental office will pay $100,000 in damages and penalties for refusing to treat a patient with HIV under a settlement reached with the U.S. Justice Dep artment. The agreement is the first AIDS-related settlement with a...

Healthcare workers who donate blood show low infection.
October 3, 1994... A U.S. Centers for Disease Control and Prevention (CDC) study suggests that HIV infection attributable to occupational exposure is uncommon among healthcare wor kers who donate blood. Approximately 8 million persons donate 13 million...

Aberrant mucosal antibodies cause AIDS-related problems.
October 3, 1994... Aberrant mucosal antibody responses and decreased integrity of the mucosal barrier may contribute to the intestinal dysfunction and infections that characterize HIV-1 infection, according to a Veteran's Affairs report. Cellular...

CPMP recommendation announces. (Committee for Proprietary Medicinal Products asks for approval of Ethyol, amifostine and NeuTrexin, trimetrexate glucuronate)
October 3, 1994... U.S. Bioscience Inc. announced that the European Union's (EU) Committee for Proprietary Medicinal Products (CPMP) has recommended approval for two products: Ethyol (amifostine), a selective cytoprotective agent; and NeuTrexin...

CD8 lymphocytes involved in hypersensitivity in HIV-infected patients.
October 3, 1994... Activated CD8 lymphocytes and perhaps epidermal production of cytokines are involved in the pathogenesis of cutaneous drug hypersensitivity in HIV-infected patients, according to a report from Australia. The pathogenesis of drug...

Local factors in lymphoid tissue may influence HIV.
October 3, 1994... Local factors such as cytokines in the lymphoid tissue probably influence t he expression of human immunodeficiency virus (HIV), according to a report from Germany. Numerous data demonstrate that lymphoid tissue represent a major HIV...

CD4+ lymphocyte number affects TB presentation and reactivation risk. (tuberculosis)
October 3, 1994... CD4+ lymphocytes play a central role in active tuberculosis (TB) in HIV-inf ected people, but a similar correlation does not appear present for CD8+ lymphocytes, accordin g to a report from an Italian research center. Researcher...

AIDS soon after infection reported in alcoholic.
October 3, 1994... Canadian researchers report a case of full-blown AIDS occurring three month s following HIV seroconversion in a 24-year-old homosexual who was also an alcoholic. Rapid progression of infection with HIV type 1 (HIV-1) to AIDS after...

Researchers study donor/recipient disease progression.
October 3, 1994... An Australian study indicates that time to both AIDS and death in patients who contract HIV infection via blood transfusion is significantly associated with the rate of disease progression in the donor. L.J. Ashton, University of...

Blood transfusion may increase HIV expression. (Research Report)
October 3, 1994... According to an abstract submitted by the authors to the 34th Interscience Conference on Antimicrobial Agents and Chemotherapy, held October 4-7, 1994, in Orlando, Flori da, "Objectives: To examine the effect of transfusion on HIV...

Disseminated tuberculosis (dTB) with and without Mycobacterium tuberculosis bacteremia (MtbB) in HIV-infected patients: clinical significance of blood cultures. (Research Report)
October 3, 1994... According to an abstract submitted by the authors to the 34th Interscience Conference on Antimicrobial Agents and Chemotherapy, held October 4-7, 1994, in Orlando, Flori da, "To determine the clinical characteristics of HIV(+) patients (pts)...

Survival of patients dually infected with HIV and tuberculosis. (Research Report)
October 3, 1994... According to an abstract submitted by the authors to the 34th Interscience Conference on Antimicrobial Agents and Chemotherapy, held October 4-7, 1994, in Orlando, Flori da, "Patients dually infected with HIV and tuberculosis (TB) are a...

Effectiveness of a short-course chemoprophylaxis (CP) of tuberculosis (TB) in HIV-seropositive and HIV-seronegative intravenous drug users (IDUs). (Research Report)
October 3, 1994... According to an abstract submitted by the authors to the 34th Interscience Conference on Antimicrobial Agents and Chemotherapy, held October 4-7, 1994, in Orlando, Flori da, "Objective: To determine the effectiveness and safety of a...

Responses of HIV-infected adults with CD4 counts <400/mm3 to recombinant gp 160 vaccine. (Research Report)
October 3, 1994... According to an abstract submitted by the authors to the 34th Interscience Conference on Antimicrobial Agents and Chemotherapy, held October 4-7, 1994, in Orlando, Flori da, "Therapeutic use of recombinant gp160 vaccine (VaxSyn,...

A pharmacoeconomic analysis of oral ganciclovir versus intravenous ganciclovir for the maintenance treatment of CMV retinitis in subjects with AIDS. (cytomegalovirus) (Research Report)
October 3, 1994... According to an abstract submitted by the authors to the 34th Interscience Conference on Antimicrobial Agents and Chemotherapy, held October 4-7, 1994, in Orlando, Flori da, "A retrospective pharmacoeconomic analysis is currently underway to...

Interleukin 7 gene therapy for HIV: immunologic effects of antigen-specific induction of an exogenous IL-7 gene in human T-cells. (Research Report)
October 3, 1994... According to an abstract submitted by the authors to the 34th Interscience Conference on Antimicrobial Agents and Chemotherapy, held October 4-7, 1994, in Orlando, Flori da, "Cytokines play a key role in the complicated interaction between...

Development of retroviral vectors that optimize the inhibition of HIV-1 at multiple points of the viral life cycle. (Research Report)
October 3, 1994... According to an abstract submitted by the authors to the 34th Interscience Conference on Antimicrobial Agents and Chemotherapy, held October 4-7, 1994, in Orlando, Flori da, "In HIV-1 infection, it may be possible to apply the technology of...

Intracellular antibodies 'intrabodies' for gene therapy of AIDS and other infectious diseases. (Research Report)
October 3, 1994... According to an abstract submitted by the author to the 34th Interscience C onference on Antimicrobial Agents and Chemotherapy, held October 4-7, 1994, in Orlando, Flori da, "Effective gene therapy of microorganisms including viruses and...

Genetic approaches for the identification of chemotherapeutic targets in Toxoplasma gondii. (Research Report)
October 3, 1994... According to an abstract submitted by the author to the 34th Interscience C onference on Antimicrobial Agents and Chemotherapy, held October 4-7, 1994, in Orlando, Flori da, "The prominence of Toxoplasma gondii in congenital infection and as...

Differential expression of mRNAs for JC virus large and small tumor antigens in brain tissues from progressive multifocal leukoencephalopathy patients with and without AIDS. (polyoma virus)(reprinted from the Proceedings of the National Academy of Sciences of the United States of America, August 16, 1994) (Periodical Report) (Abstract)
October 3, 1994... According to the authors' abstract of an article published in Proceedings o f the National Academy of Sciences of the United States of America, "JC virus (JCV) causes prog ressive multifocal leukoencephalopathy (PML), the fatal demyelinating...

Quantitation of human immunodeficiency virus type 1 during pregnancy: relationship of viral titer to mother-to-child transmission and stability of viral load. (reprinted from the Proceedings of the National Academy of Sciences of the United States of America, August 16, 1994) (Periodical Report) (Abstract)
October 3, 1994... According to the authors' abstract of an article published in Proceedings o f the National Academy of Sciences of the United States of America, "To develop strategies to p revent mother-to-child transmission of human immunodeficiency virus...

Synthesis of naphthalenesulfonic acid small molecules as selective inhibitors of the DNA polymerase and ribonuclease H activities of HIV-1 reverse transcriptase. (reprinted from the Journal of Medicinal Chemistry, August 5, 1994) (Periodical Report) (Abstract)
October 3, 1994... According to the authors' abstract of an article published in the Journal o f Medicinal Chemistry, "Over 25 selected naphthalenesulfonic acid derivatives were evaluated for their inhibitory effect on two different functional domains of the...

Maternal-newborn human immunodeficiency virus infection in Harlem. (reprinted from the Archives of Pediatrics and Adolescent Medicine, August 1994) (Periodical Report) (Abstract)
October 3, 1994... According to the authors' abstract of an article published in Archives of P ediatrics & Adolescent Medicine, "Objective: To determine the prevalence of human immunodef iciency virus type 1 (HIV-1) infection and its association with illicit...

NIAID mycoses study group multicenter trial of oral itraconazole therapy for invasive aspergillosis. (Reprinted from the American Journal of Medicine, August 1994) (Periodical Report) (Abstract)
October 3, 1994... According to the authors' abstract of an article published in the American Journal of Medicine, "Background: Invasive aspergillosis is the most common invasive mould infection and a major cause of mortality in immunocompromised patients....

Antisense oligodeoxynucleotide phosphorothioate complementary to Gag mRNA blocks replication of human immunodeficiency virus type 1 in human peripheral blood cells. (reprinted from the Proceedings of the National Academy of Sciences of the United States of America, August 16, 1994) (Periodical Report) (Abstract)
October 3, 1994... According to the authors' abstract of an article published in Proceedings o f the National Academy of Sciences of the United States of America, "Gene-expression modulator 91 (GEM91) is a 25-nt antisense oligodeoxynucleotide phosphorothioate...

The HIV-1 protease as enzyme and substrate: mutagenesis of autolysis sites and generation of a stable mutant with retained kinetic properties. (reprinted from Biochemistry, August 16, 1994) (Periodical Report) (Abstract)
October 3, 1994... According to the authors' abstract of an article published in Biochemistry, "Site-directed mutagenesis of autolysis sites in the human immunodeficiency virus type 1 (HIV-1 ) protease was applied in an analysis of enzyme specificity; the...

High predictive value of the acid-fast smear for Mycobacterium tuberculosis despite the high prevalence of Mycobacterium avium complex in respiratory specimens. (reprinted from Clinical Infectious Diseases, August 1994) (Periodical Report) (Abstract)
October 3, 1994... According to the authors' abstract of an article published in Clinical Infe ctious Diseases, "The value of the smear for acid-fast bacilli in predicting pulmonary tuberculos is is unclear in a setting where there is a high prevalence of...

False-positive human immunodeficiency virus screening test related to rabies vaccination. (reprinted from the Archives of Pathology and Laboratory Medicine, August 1994) (Periodical Report) (Abstract)
October 3, 1994... According to the authors' abstract of an article published in Archives of P athology & Laboratory Medicine, "We report a false-positive result on an enzyme immuno-assa y screening test for antibodies to human immunodeficiency virus in a...

JAMA and Science square off in latest Gallo controversy. (Journal of the American Medical Association; Robert Gallo paper on Kaposi's sarcoma drug)
October 10, 1994... An extraordinary exchange of contentious letters in the Journal of the Amer ican Medical Association (JAMA) expands the latest controversy involving AIDS researcher Robe rt Gallo. The debate, which could be called The Case of the...

Liposome Technology to file NDA. (new drug application for DOX-SL)
October 10, 1994... Liposome Technology Inc. (LTI), Menlo Park, California, announced that the Committee on Proprietary and Medicinal Products (CPMP) of the European Union (EU) countrie s has formally confirmed that LTI's DOX-SL Stealth liposome product...

Two new Kaposi's sarcoma cell lines characterized.
October 10, 1994... Researchers in Italy report the establishment and characterization of two n ew Kaposi's sarcoma (KS) cell cultures, one from a patient with AIDS and the other in a non- AIDS patient. KS is now found as an opportunistic lesion present...

Thalidomide enters Phase II study for wasting.
October 10, 1994... Celgene Corporation, Warren, New Jersey, initiated Phase II clinical evalua tion of thalidomide at two U.S. centers as a treatment for cachexia, or wasting, an emac iating condition that results in significant weight loss in advanced AIDS...

Automated screening test may facilitate mass screening. (HIV antibody test)
October 10, 1994... Researchers from Japan believe an automated screening test to detect antibo dy to HIV-1 in whole blood that they have developed is useful for testing hospital patients and for mass screening. Juzo Matsuda, Teikyo University School of...

Several HIV-1 RNA assays ready for clinical trials.
October 10, 1994... A number of HIV-1 RNA quantitative assays aimed at predicting clinical resp onse to therapy are ready for use in clinical trials, according to a multicenter report. Numerous immunologic and virologic surrogate markers have been used...

Initial level of mycobacteremia predictive of survival.
October 10, 1994... The initial level of mycobacteremia in patients with disseminated Mycobacte rium avium complex disease and AIDS may have significant prognostic value, according to a r eport from the U.S. Centers for Disease Control and Prevention (CDC). ...

Overlap between HIV and TB restricted in France. (tuberculosis)
October 10, 1994... The overlap between the population with HIV infection and that with tubercu losis (TB) in France seems to be small and restricted to a particularly vulnerable sub-group, according to a recent study. The possible impact of HIV...

AIDS explosion among IDU in Bangkok just beginning. (injection drug users)
October 10, 1994... During the 1990s the number of cases of AIDS and other HIV-related diseases in the population of HIV-infected injection drug users (IDU) in Bangkok, Thailand, will increase dramatically, placing new demands on existing healthcare...

Biopharmaceutics announces new agreement. (with the Research Foundation of State University of New York at Stony Brook for antiviral compound)
October 10, 1994... Biopharmaceutics Inc., Bellport, New York, announced that it has acquired t he rights to a patented "Antiviral Composition and Method," consisting of ingredients which are "generally recognized as safe and effective" in humans (GRAS...

Nigerians divided on AIDS prevalence.
October 10, 1994... The World Health Organization (WHO) estimates that more than half a million people in Africa had AIDS in 1993 alone. According to the WHO, another 10 million Africans now carry HIV, including more than half a million in Nigeria. ...

French ex-minister charged for blood contamination. (Edmond Herve)
October 10, 1994... A second French cabinet-level official has been charged in connection with blood transfusions tainted with HIV that infected more than 1,200 hemophiliacs in 1985 . Former Health Minister Edmond Herve was charged with conspiracy to...

AIDS workers acknowledge homosexuality. (Zambia)
October 10, 1994... The AIDS epidemic is forcing Zambians to acknowledge a phenomenon they have always pretended does not exist in their country: homosexuality. It has always been fashionable for people in this southern African country to dismiss...

Sexual abuse predictive of high HIV risk behavior.
October 10, 1994... Childhood sexual abuse appears to be directly related to later sexual behav ior that is high risk for HIV infection, according to a report from the University of Alabama Cen ter for AIDS Research. "One consequence of childhood sexual...

Rabies vaccination related to false-positive EIA for HIV. (enzyme immunoassay)
October 10, 1994... Researchers from Pennsylvania reported a false HIV-positive result on an en zyme immunoassay (EIA) screening test in a blood donor without risk behavior that is believed to be related to rabies vaccination. Eugene S. Pearlman, M.D.,...

Childbirth events may influence infant HIV transmission.
October 10, 1994... Events at childbirth may be associated with maternal-infant HIV transmissio n, according to a report from New York's Columbia University. Knowledge of the timing of maternal-infant HIV transmission, whether in ute ro or at the time...

Drug use greater risk factor for HIV than prostitution.
October 10, 1994... A study from the United Kingdom found that there was no higher HIV prevalen ce among female intravenous drug users (IVDU) also involved in prostitution than among IV DU who were not prostitutes. There is an established connection...

Demand for bold steps on women and spread of HIV. (Donna Shalala speech at the Pan American Sanitary Conference)
October 10, 1994... Providing healthy futures for our children, improving the health and safety of women, and putting an end to the suffering caused by AIDS are the greatest challenges to th e countries of the Americas, according to Dr. Donna E. Shalala,...

A novel effector kinase to NFkB that activates latent HIV. (Research Report)
October 10, 1994... According to an abstract submitted by the authors to the X International Co nference on AIDS, held August 7-12, 1994, in Yokohama, Japan, "Objective: NFKB is an induci ble cellular transcription factor that regulates a wide variety of...

Molecular evidence for a block in Rev-function in chronically HIV-1-infected human glial cells. (Research Report)
October 10, 1994... According to an abstract submitted by the authors to the X International Co nference on AIDS, held August 7-12, 1994, in Yokohama, Japan, "Objective: The cloned chroni cally HIV-infected human astrocytoma cell line TH4-7-5 shows only a very...

Phase I/II trial of oral Panavir for HIV infection. (Research Report)
October 10, 1994... According to an abstract submitted by the authors to the X International Co nference on AIDS, held August 7-12, 1994, in Yokohama, Japan, "Objective: To determine safe ty, efficacy and bioavailability of Panavir...

HIV-1/HTLV-I coinfection is associated with a high frequency of myelopathies. (Research Report)
October 10, 1994... According to an abstract submitted by the authors to the X International Co nference on AIDS, held August 7-12, 1994, in Yokohama, Japan, "Introduction: Although in po stmortem examinations myelopathies are found in up to 30% of...

AIDS in Africa: the epidemiology of HIV-associated tuberculosis and heterosexual transmission. (Research Report)
October 10, 1994... According to an abstract submitted by the author to the X International Con ference on AIDS, held August 7-12, 1994, in Yokohama, Japan, "Objectives: To review the ep idemiological characteristics of HIV-associated tuberculosis in Africa...

Mapping CD4 T-lymphocyte epitopes in a long-term survivor. (Research Report)
October 10, 1994... According to an abstract submitted by the authors to the X International Co nference on AIDS, held August 7-12, 1994, in Yokohama, Japan, "Objective: Distinctive immun ologic and virologic characteristics of long-term survivors may...

Rhesus monkeys immunized with soluble rhesus CD4 develop anti-CD4 antibody with anti SIVmac activity. (Research Report)
October 10, 1994... According to an abstract submitted by the authors to the X International Co nference on AIDS, held August 7-12, 1994, in Yokohama, Japan, "Objective: In view of the ef ficiency with which AIDS virus replication can be blocked in vitro with...

The interrelations between STDs, HIV and tuberculosis in Colombo district of Sri Lanka. (sexually transmitted diseases) (Research Report)
October 10, 1994... According to an abstract submitted by the author to the X International Con ference on AIDS, held August 7-12, 1994, in Yokohama, Japan, "Objective: To explore the ri sks generated by high Tuberculosis incidence rates in Colombo District on...

HIV-1 V3 serotypes: distribution and correlation with genotypes. (Research Report)
October 10, 1994... According to an abstract submitted by the authors to the X International Co nference on AIDS, held August 7-12, 1994, in Yokohama, Japan, "Objectives: To serotype HIV- 1, to determine the distribution of HIV-1 serotypes worldwide and to...

High serum prolactin levels in asymptomatic HIV-infected patients and in patients with acquired immunodeficiency syndrome. (reprinted from Clinical Immunology and Immunopathology, September 1994) (Periodical Report) (Abstract)
October 10, 1994... According to the authors' abstract of an article published in Clinical Immu nology and Immunopathology, "Prolactin (PRL) is an immunostimulatory hormone that is increa sed in serum of patients with systemic lupus erythematosus (SLE). On the...

Induction of humoral and cellular immunity to simian immunodeficiency virus: what are the requirements for protection? (reprinted from Vaccine, September 1994) (Periodical Report) (Abstract)
October 10, 1994... According to the authors' abstract of an article published in Vaccine, "In an effort to produce a strong humoral and cellular immune response that might protect against simian immunodeficiency virus (SIV) infection, groups of five rhesus...

Cryptic nature of envelope V3 region epitopes protects primary monocytotropic human immunodeficiency virus type 1 from antibody neutralization. (reprinted from Journal of Virology, September 1994) (Periodical Report) (Abstract)
October 10, 1994... According to the authors' abstract of an article published in the Journal o f Virology, "Characterization of biological and immunological properties of human immunodefi ciency virus type 1 (HIV-1) is critical to developing effective...

Immunization with a soluble CD4-gp120 complex preferentially induces neutralizing anti-human immunodeficiency virus type 1 antibodies directed to conformation-dependent epitopes of gp120. (reprinted from Journal of Virology, September 1994) (Periodical Report) (Abstract)
October 10, 1994... According to the authors' abstract of an article published in the Journal o f Virology, "Preservation of the conformation of recombinant gp120 in an adjuvant, enabling it to elicit conformation-dependent, epitope-specific, broadly...

Expression of HIV-1 envelope gene by recombinant avipox viruses. (reprinted from Vaccine, September 1994) (Periodical Report) (Abstract)
October 10, 1994... According to the authors' abstract of an article published in Vaccine, "Rec ombinant canarypox (CP) and fowl pox (FP) viruses that contained two forms of the HIV-1 ( SF2 strain) env gene were engineered and their expression analyzed in...

Humoral and cell-mediated immunity in rabbits immunized with live non-replicating avipox recombinants expressing the HIV-1(SF2) env gene. (reprinted from Vaccine, September 1994) (Periodical Report) (Abstract)
October 10, 1994... According to the authors' abstract of an article published in Vaccine, "The canarypox (CP) and fowl pox (FP) viruses, which are unable to replicate productively in non-avi an species, have been utilized as live vectors carrying the...

Increased concentrations of soluble tumor necrosis factor receptor 75 but not of soluble intercellular adhesion molecule-1 are associated with the decline of CD4+ lymphocytes in HIV infection. (reprinted from Clinical Immunology and Immunopathology, September 1994) (Periodical Report) (Abstract)
October 10, 1994... According to the authors' abstract of an article published in Clinical Immu nology and Immunopathology, "Immune activation seems to be involved in the pathogenesis of human immunodeficiency virus (HIV) infection. The immune activation...

Characterization of a recombinant antibody produced in the course of a high yield fed-batch process. (reprinted from Biotechnology and Bioengineering, September 5, 1994) (Periodical Report) (Abstract)
October 10, 1994... According to the authors' abstract of an article published in Biotechnology and Bioengineering, "Many mammalian cell fed-batch processes rely on maintaining the cells in a viable and productive state for extended periods of time in order...

Emergence of fluconazole-resistant strains of Candida albicans in patients with recurrent oropharyngeal candidosis and human immunodeficiency virus infection. (reprinted from Journal of Clinical Microbiology, September 1994) (Periodical Report) (Abstract)
October 10, 1994... According to the authors' abstract of an article published in the Journal o f Clinical Microbiology, "After repeated use of fluconazole for therapy of oropharyngeal ca ndidosis, the emergence of in vitro fluconazole-resistant Candida...

Ganciclovir - an update of its therapeutic use in cytomegalovirus infection. (reprinted from Drugs, September 1994) (Periodical Report) (Abstract)
October 10, 1994... According to the authors' abstract of an article published in Drugs, "The a ntiviral nucleoside analogue ganciclovir has demonstrated in vitro activity against human cytomegalovirus and effectively treats infection caused by this organism...

Virus-specific CD8+ cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection. (reprinted from Journal of Virology, September 1994) (Periodical Report) (Abstract)
October 10, 1994... According to the authors' abstract of an article published in the Journal o f Virology, "Human immunodeficiency virus type 1 (HIV-1) Env-, Gag-, Pol-, Nef-, and Tat-spe cific cytotoxic T-lymphocyte (CTL) activities were quantitated...

HIV-1 envelope-elicited neutralizing antibody titres correlate with protection and virus load in chimpanzees. (reprinted from Vaccine, September 1994) (Periodical Report) (Abstract)
October 10, 1994... According to the authors' abstract of an article published in Vaccine, "In an attempt to compare the protective effect of vaccination with two forms of envelope antigens , and to define immunological correlates of protection against HIV...

Superantigens activate HIV-1 gene expression in monocytic cells. (reprinted from Clinical Immunology and Immunopathology, September 1994) (Periodical Report) (Abstract)
October 10, 1994... According to the authors' abstract of an article published in Clinical Immu nology and Immunopathology, "Binding of superantigens to MHC class II molecules results in transduction of biochemical signals leading to cellular activation and...

A human immunodeficiency virus type 1 (HIV-1)-based retroviral vector system utilizing stable HIV-1 packaging cell lines. (reprinted from Journal of Virology, September 1994) (Periodical Report) (Abstract)
October 10, 1994... According to the authors' abstract of an article published in the Journal o f Virology, "We have constructed stable human immunodeficiency virus (HIV) packaging cell lines that when transfected with an HIV-based retroviral vector produce...

"Intrabodies" for gene therapy of AIDS. (intracellular antibodies) (34th Interscience Conference on Antimicrobial Agents and Chemotherapy)
October 24, 1994... Intracellular antibodies - dubbed intrabodies - are a powerful new technology applicable to AIDS therapy, a Harvard researcher suggested at the 34th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), held October 4-7,...

Stop HIV replication with multi-target gene therapy, NIH researcher says. (National Institutes of Health; Richard A. Morgan) (34th Interscience Conference on Antimicrobial Agents and Chemotherapy)
October 24, 1994... The battle against HIV should be waged within cells, an NIH researcher said at the 34th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), held October 4-7, 1994, in Orlando, Florida. In a featured gene therapy...