AIDS Weekly articles from November 2003

AIDS Weekly archives from November 2003

Improved method for aryl beta-diketo acids developed.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- A novel oxalylation technique may lead to increased production of anti-HIV beta-diketo acids. According to published study results from China, "An improved and efficient oxalylation of aryl methyl...

MAGI assay improves HIV detection in female genital secretions.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- The MAGI assay improves detection of HIV in female genital secretions. "Infectious human immunodeficiency virus type 1 (HIV-1) is difficult to detect in female genital secretions by standard virus...

FDG-PET imaging shows HIV progression.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- FDG-based positron emission tomography (PET) can be used to track HIV disease progression. FDG-PET is already known to detect "active lymphoid tissues during HIV-1 infection in man," scientists in...

Dimeric derivatives of peptide HIV integrase inhibitors show improved efficacy.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Dimeric derivatives of peptide HIV integrase inhibitors show improved efficacy over their parent agents. In a recent study from the United States, "Dimers of known HIV-1 integrase inhibitory...

Female HIV patients have higher risk of antiretroviral-induced ATAs.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Female HIV patients have higher risk of antiretroviral-induced adipose tissue alterations (ATAs) compared to their male counterparts. In a recent study from Italy, ATAs "were clinically assessed in...

Indinavir suppresses transendothelial migration of immature dendritic cells.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- The anti-HIV agent indinavir (IDV) suppresses the transendothelial migration of some immature immune cells. IDV "is a protease inhibitor that successfully suppresses HIV-1 replication as part of...

Gates Foundation doubles grant for India.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- The Bill and Melinda Gates Foundation says it is doubling, to $200 million, the prevention funds for HIV and AIDS that the Microsoft chairman promised India in a visit last year. The announcement...

VScan test kits are being shipped to People's Republic of China.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Medical Services International (MSITF) has received a letter of intent to supply 250,000 VScan HIV rapid-test kits to a major Chinese pharmaceutical company in the People's Republic of China. ...

FDA grants anti-CD4 drug fast-track status for the treatment of HIV-1.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Tanox, Inc., (TNOX) announced that the U.S. Food and Drug Administration (FDA) has granted fast-track status to TNX-355 for the treatment of patients with human-immunodeficiency virus 1 (HIV-1)...

Proteins enable HIV to override cell's defenses.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Researchers at the Johns Hopkins Bloomberg School of Public Health have identified a complex series of proteins that enable HIV to bypass the natural defenses of human cells and replicate. The...

Advanced genomic technologies used as focus of alliance.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Cenetron Diagnostics, Ltd., a leading provider of molecular diagnostic services, announced it has signed a 5-year strategic alliance agreement with Roche Diagnostics to establish itself as a Molecular...

Alliance will focus on infectious, parasitic disease research.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Invest U.K., the British government's worldwide inward investment agency, announced that the U.S. Centers for Disease Control and Prevention (CDC) has signed a formal memorandum of understanding with...

Glycolytic enzyme plays key role in L-nucleoside analog efficacy.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- An enzyme crucial for the efficacy of L-nucleoside analogs has been identified. These drugs represent "a new class of clinically active antiviral and anticancer agents," scientists in the United...

Cancer vaccine company completes UKP 17M financing.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- BioVex, Ltd., announced the completion of a UKP 17 million (U.S. $28 million) private placement. The placement was led by Scottish Equity Partners (U.K.). Other new investors participating in the...

China clinical trials completed for antibody tests.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Calypte Biomedical Corporation (CYPT), the developer and marketer of the only two U.S. Food and Drug Administration (FDA) approved HIV-1 antibody tests that can be used on urine samples, as well as an...

U.N. report warns of HIV/AIDS among adolescents.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Early marriage, unwanted pregnancy, and HIV/AIDS among the world's adolescents are a threat to development and must be combated as part of the war on poverty, the United Nations says. A fifth of...

Substantial increase in survival seen after introduction of HAART.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- New research highlights the substantial increased survival for people with HIV-1 since the introduction of highly active antiretroviral therapy (HAART) in 1997. However the study also shows a shift...

HLA-B22 alleles linked to rapid disease progression in white HIV patients.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- HLA-B22 alleles exert a potent influence over the course of HIV infection in white patients. "The human leukocyte antigen (HLA)-B22 serogroup - which consists of the alleles B*54, B*55, and B*56 -...

Highly virulent X4-tropic CRF02.AG HIV isolate cloned.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- A highly virulent, T-cell-tropic CRF02.AG HIV isolate from Africa has been cloned. "Based on our previous analysis of HIV-1 isolates from Cameroon," scientists in Germany "constructed a full-length...

SHIV Nef ITAM deletions linked to loss of virulence in macaques.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Deletions in the ITAM motif of simian-human immunodeficiency virus (SHIV) Nef protein cause of loss of virulence in macaques. According to published research from France, "SHIVsbg, expressing Vpu,...

Modified HIV PIs active against drug-resistant virus, but lack bioavailability.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- A series of modified HIV PIs are highly active against PI-resistant strains, but have limited bioavailability. According to published research from Merck Research Laboratories, "Transposition of...

Plasma-derived HIV should be used for drug resistance genotyping.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Plasma-derived HIV should be used for viral genotyping to determine drug resistance. "HIV-1 genotype assays using plasma viruses have been widely applied for detection of resistant viruses in...

Genetic therapy options for HIV patients reviewed.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Gene therapy options for HIV patients have been reviewed. "Despite the tremendous success of highly active antiretroviral treatment (HAART) introduced nearly eight years ago for the treatment of...

HIV sensitivity to RANTES neutralization can mark disease progression.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- HIV sensitivity to RANTES neutralization can be used to help mark disease progression. "In approximately half of human immunodeficiency virus (HIV) type 1-infected individuals, the development of...

Reduced NCR expression underlies NK cell dysfunction during HIV infection.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Reduced NCR expression underlies NK cell dysfunction during HIV infection "Signals leading to NK cell triggering are primarily mediated by natural cytotoxicity receptors (NCR) upon binding to...

CSF analysis vital for diagnosis of opportunistic CNS infections in HIV patients.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- CSF analysis is vital for the diagnosis of opportunistic CNS infections in HIV patients. "In up to 50% of all human immunodeficiency virus (HIV) patients, the nervous system is clinically involved,"...

Oral epithelial cells can be infected with HIV in vitro.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Cultured oral epithelial cells are vulnerable to HIV infection. "Epithelial cells lining the oral cavity are exposed to HIV-1 through breast-feeding and oral-genital contact," scientists in the...

Some HIV-2 strains don't use normal HIV coreceptors.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Some HIV-2 strains don't use the normal HIV coreceptors for cell entry. "In vivo, human immunodeficiency virus type 2 (HIV-2) infection reveals several unique characteristics when compared to HIV-1...

Mathematical model predicts effects of microbicide-based HIV prevention efforts.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- A novel statistical technique can be used to predict the effects of microbicide-based HIV prevention efforts. In a recent study, scientists in the United States developed "a simple mathematical...

Yeast model aids study of CCR5 activation.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- A yeast model has enabled a detailed characterization of CCR5 signaling. "CCR5 is a G protein-coupled receptor for RANTES, MIP-1alpha, MIP-1beta, and MCP-2 that functions as the front line...

Antiretroviral treatment can impair antimalarial immune activity.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Antiretroviral treatment can impair antimalarial immune activity. "In response to the HIV/AIDS pandemic, antiretroviral treatment is currently being implemented in sub-Saharan Africa, where malaria...

Efavirenz analog binding to K103N HIV mutants determined.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- The factors that determine efavirenz analog binding to mutant HIV RT have been identified. In a recent study from the United States, "Monte Carlo-extended linear response (MC/ELR) calculations"...

Effect of blood-brain barrier on hydroxyurea elucidated.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- The effect of the blood-brain barrier on hydroxyurea pharmacokinetics has been elucidated. "Hydroxyurea is used in the treatment of HIV infection in combination with nucleoside analogues,...

Birth order in twins has no effect on HIV transmission risk.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Contrary to previous reports, birth order in twins has no effect on HIV vertical transmission risk. In a recent study, scientists in the United States "examined birth order and delivery route as...

Adjuvant licensed for the development of HIV vaccine.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- The Immune Response Corporation (IMNR) and Hybridon, Inc., (HYBN) have entered into a license agreement for the use of Amplivax as an adjuvant in the development of a novel vaccine candidate for the...

The HTLV-1 virus depends on TAXREB803 for Tax gene transactivation.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- The HTLV-1 virus depends on TAXREB803 for Tax gene transactivation. "Expression of the human T cell lymphotropic virus type 1 (HTLV-1) genes is transcriptionally activated by the cognate oncoprotein...

Amphotericin B lipid complex safe, effective for HIV visceral leishmaniasis treatment.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- A lipid formulation of amphotericin B is safe and effective for the treatment of VL in HIV patients. "Optimal treatment for HIV-related visceral leishmaniasis (VL) has still to be established,"...

Company announces protein biomarker-detection capabilities.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Through a licensing agreement with Northwestern University, Nanosphere, Inc., a nanotechnology-based life-sciences company, has acquired nanoparticle-detection technology for protein biomarkers. ...

Multicenter study launched for HIV-associated neuropathy.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- NeurogesX, Inc., announced the initiation of a phase II/III clinical study of NGX-4010 for the treatment of neuropathic pain associated with HIV infection and AIDS. Neuropathic pain is often the...

Protease inhibitors used for treating HIV also block Kaposi sarcoma.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Protease inhibitors used for treating HIV also block Kaposi sarcoma. According to recent research from Italy, "HIV protease inhibitors are antiretroviral drugs that block the enzyme required for...

P. carinii PCM involved in cyst transition.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- The P. carinii mitogen-activated protein kinase (MAPK) PCM is involved in its transition to cyst form. MAPK pathways "transfer environmental signals into intracellular events such as proliferation...

Murine model may aid study of opportunistic histoplasmosis.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- A novel murine model may aid research on opportunistic histoplasmosis in HIV and other immunocompromised patients. "Use of a pulmonary model of histoplasmosis in CD4/CD8 lymphocyte-depleted animals...

Novel genetic markers useful for Encephalitozoon hellem typing.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- A series of newly identified genetic markers can aid the epidemiological study of the opportunistic pathogen Encephalitozoon hellem. In a recent study from Spain, seven E. hellem isolates collected...

Valacyclovir inhibits EBV replication in HIV-associated HLP.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Valacyclovir can suppress EBV activity in patients with HIV-related HLP. In a recent study from the United States, "Nineteen cases of human immunodeficiency virus (HIV)-associated oral hairy...

Drug may protect cancer and AIDS patients from side effects.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- A drug developed to relieve one of the major side effects of pain therapy for cancer patients may offer an added benefit for AIDS patients, researchers from the University of Chicago and the Children's...

Needle exchange programs reduce risky behavior but are rarely used by young IDUs.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Needle exchange programs (NEP) can reduce risky behavior, but young drug users rarely take advantage of them. In a recent study, scientists in the United States "analyzed factors associated with"...

New scientific study finds forgiveness a factor in decreasing spread of AIDS.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- A new study shows that forgiving may be a factor in placing others at risk of contacting AIDS. In a longitudinal study, both feeling forgiven and forgiving others were associated with less depression...

Vatican position on condom use and HIV scientifically incorrect says U.N. agency.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- A statement by the president of the Vatican's Pontifical Council on the Family that condoms do not protect people from HIV is scientifically incorrect and could contribute to the spread of the virus,...

Grant to confirm efficacy of pathogen-inactivation technology on plasma.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- The National Heart Lung and Blood Institute of the U.S. National Institutes of Health (NIH), in conjunction with the Small Business Administration, has provided a $750,000 small business innovation...

Drug relieves opioid-induced urinary retention in phase II trial.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Progenics Pharmaceuticals, Inc. (PGNX) announced that the investigational drug methylnaltrexone (MNTX) relieved opioid-induced urinary retention in a phase II clinical trial. Inability to urinate...

DNA condensation by HIV NCp7 has protective role.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- DNA condensation by the HIV protein NCp7 helps maintain viral DNA stability in the cellular environment. "The nucleocapsid (NC) protein NCp7 of the human immunodeficiency virus type 1 is a small...

Adenosine analogs have potent antiretroviral activity in vitro.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- A series of adenosine analogs have demonstrated promising antiretroviral activity in vitro. In a recent study from the United States, "Eight adenosine analogs, 3-deaza-adenosine (DZA), 3-deaza-([+...

Retroviral protein triggers proliferation of immune cells.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- Scientists at Ohio State University have found that a protein in the retrovirus known as human T-cell lymphotropic virus type 1 (HTLV-1) can cause immune cells to divide and proliferate, helping the...

Clear proof offered that HIV virus cannot pass through condoms.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- Questions have arisen recently over whether the HIV virus can or cannot pass through pores in latex condoms. European Union (E.U.) research projects provide extensive proof that this is not the case:...

Reticulated platelet assay helps identify HIV-related ITP.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- The RP assay can be used to distinguish normal and HIV-related immune thrombocytopenic purpura (ITP). Diagnosis of ITP is currently "based on low platelet count and exclusion of clinical...

Functional CD4 cell recovery after HAART linked to IL-2 production.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- Recovery of CD4 cell function after anti-HIV therapy is linked to renewed IL-2 production. "Reconstitution of functional CD4+ T-cell responsiveness to in vitro stimuli is associated with continuous...

Medical Services to participate in live testing with the military in China.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- Medical Services International, Inc., (MSITF) has agreed to participate in a live testing program with a military hospital in the northern military district of the People's Republic of China. The...

Drugmaker cuts costs on HIV/AIDS medications.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- GlaxoSmithKline (GSK) has reduced the not-for-profit prices of its HIV/AIDS medicines for qualifying countries and organizations. It has also extended the voluntary license granted to Aspen...

Novel gp41 crystal structure licensed from Cornell Research Foundation.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- Locus Pharmaceuticals, Inc., a privately held pharmaceutical company focused on developing small-molecule therapeutics, has licensed from Cornell Research Foundation a proprietary crystal structure of...

HIV test maker signs agreement with lab company.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- Calypte Biomedical Corporation (CYPT), the developer and marketer of the only two U.S. Food and Drug Administration (FDA) approved HIV-1 antibody tests for use with urine samples, announced that the...

Curcumin shows promise as intravaginal spermicide and anti-HIV agent.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- Curcumin shows promise as an intravaginal spermicide and anti-HIV agent. According to published research from the United States, "The purpose of this investigation was to evaluate the...

Real-time PCR aids HIV DNA quantification.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- A novel molecular assay aids measurement of cellular HIV DNA. Virologists in Japan developed a "real-time PCR assay to accurately quantify human immunodeficiency virus type 1 (HIV-1) DNA in...

High glucose uptake in FDG PET is an indication for pulmonary cryptococcoma.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- FDG PET scans may help differentiate between pulmonary cryptococcoma and cancer; high glucose uptake indicates infectious origin. According to a study from Taiwan, "Cryptococcosis is not uncommon....

Antiretroviral activity of BMS-378806 characterized.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- The antiretroviral activity of BMS-378806 has been characterized. "BMS-378806 is a recently discovered small-molecule human immunodeficiency virus type I (HIV-1) attachment inhibitor with good...

Indole derivative shows potent anti-HIV activity with improved bioavailability.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- A novel indole derivative shows potent antiretroviral activity with improved bioavailability. "Indole derivative 1 interferes with the interaction of the HIV surface protein gp120 with the host...

Rational design useful for development of HIV-stimulating agents.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- Rational design can be used to develop agents that stimulate HIV replication, rendering latent virus susceptible to other antiretroviral drugs. "Drugs that induce human immunodeficiency virus type...

Snake venom-derived LAO with anti-HIV activity described.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- A snake venom-derived LAO with antiretroviral activity has been described. According to recent research from China, "A novel L-amino acid oxidase, named TSV-LAO, has been purified and cloned from...

Novel enzymatic test quickly determines HIV PI resistance.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- A novel enzymatic test can be used to quickly determine HIV protease inhibitor resistance. According to published research from Germany, "A phenotypic resistance test based on recombinant...

Biopharmaceutical corporation plans $12 million private placement financing.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- The Immune Response Corporation (IMNR) has entered into agreements to sell, through a private placement, approximately 6 million shares of common stock at $2.02 per share to a number of unaffiliated...

U.S. agency opens Beijing office to help fight AIDS amid new candor by China.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- Seeking to bolster China's newfound readiness to fight AIDS, a U.S. government program meant to help poor countries with the disease opened an office in Beijing and urged greater official efforts. ...

No World Vision purchase from Calypte Biomedical.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- A September 16 announcement from Calypte Biomedical Corporation reporting that World Vision intends to purchase $4 million worth of its urine-based HIV/AIDS test kits is incorrect. World Vision has no...

Activated microglia protect against HIV-related neurotoxicity.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- Activated microglia help protect against HIV-induced neurotoxicity. According to a study from France, "Recent experimental studies showed that activated macrophages/microglia (AMM) express...

HIV and IL-1beta regulate astrocyte FasL expression through the NF-kappa B pathway.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- HIV and IL-1beta regulate astrocyte FasL expression through the NF-kappa B pathway. "Reactive astrogliosis is a prominent pathological feature of HIV-1-associated dementia (HAD)," according to...

Multiplex real-time PCR assay improves measurement of HIV DNA load.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- A novel molecular assay aids HIV DNA load measurements. Scientists in Sweden "established a simple system for measuring HIV-1 DNA load in CD4+ cells." "In a multiplex configuration, a...

Universal retrovirus DNA chip shows promise as diagnostic tool.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- A universal retrovirus DNA chip shows promise as a diagnostic tool. According to published research from Germany, "A DNA chip-based assay is described for parallel detection and identification of...

DCs loaded with yeast-derived HIV particles immunogenic during chronic infection.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- DCs loaded with yeast-derived HIV particles are immunogenic during chronic infection. "To evaluate the immunogenicity of human immunodeficiency virus (HIV type I p55(gag) virus-like particles...

Early transcription from nonintegrated HIV DNA possible.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- Nonintegrated HIV DNA is capable of early transcription. "Replication of human immunodeficiency virus (HIV) involves obligatory sequential processes. Following viral entry and reverse...

HIV Nef does not affect the efficiency of viral cell fusion.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- The HIV Nef protein does not affect the efficiency of viral cell fusion. HIV Nef "stimulates viral infectivity by an unknown mechanism," scientists in Tennessee explained. "Recent studies have...

HIV Vpu prevents apoptosis of infected CD4 cells.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- The HIV Vpu protein prevents apoptosis of infected CD4 cells. According to a published research from Japan, "Previous data revealed that primary cultures of peripheral blood mononuclear cells...

Prognostic CCR5 mutations affect co-receptor expression.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- Prognostically useful CCR5 mutations affect the density of the HIV co-receptor on mononuclear cell surfaces. "The common CCR5 promoter polymorphism at position -2459 (A/G) has been associated with...

Proteins needed for MVB biogenesis involved in HIV budding.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- Several proteins which induce MVB budding also play key roles in the release of HIV particles from infected cells. "HIV release requires TSG101, a cellular factor that sorts proteins into vesicles...

LPS-based assay provides accurate measure of HIV-specific immunity.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- A novel LPS-based assay provides an accurate measure of HIV-specific immunity. According to a study from the United States, "The accurate determination of human immunodeficiency virus type 1...

Mathematical model suggests high efficacy for genetically engineered anti-HIV viruses.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- A statistical model suggests a high efficacy for HIV treatment based on therapeutic viruses. In a recent study from the United States, "a mathematical model" was used to evaluate "a potential...

Mucosal delivery of HIV-1 Tat protein elicits strong immune response.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- Mucosal delivery of the human immunodeficiency virus-1 Tat protein in mice elicits systemic neutralizing antibodies, cytotoxic T lymphocytes, and mucosal IgA According to a study from Italy, "Human...