AIDS Weekly articles from May 1995

AIDS Weekly archives from May 1995

Castanospermine derivative has anti-HIV synergy in divergent combinations.
May 29, 1995... A derivative of a compound first extracted from the Australian chestnut tree exhibits anti-HIV synergy with three different types of anti-HIV drugs. The compound, 6-0-butanoylcastanospermine or MDL 28,574, was most effective as part of...

Study suggests 13 percent of those HIV+ are long-term survivors.
May 29, 1995... Approximately 13 percent of homosexual/bisexual men infected with HIV at an early age will be long-term survivors, remaining free of disease for more than 20 years, according to the predictions of researchers involved in the Multicenter AIDS...

Pregnancy hormone knocks out Kaposi's sarcoma.(beta chorionic gonadotropin)
May 29, 1995... A hormone produced during the early stages of pregnancy kills Kaposi's sarcoma (KS) cells but does not affect normal cells. These new findings - which appear to offer a novel treatment strategy for one of the most feared sequelae of AIDS -...

Treatment of Kaposi's sarcoma with interleukin-1 receptor antagonist evaluated.
May 29, 1995... Researchers evaluated the effects of Interleukin-1 (IL-1) and Interleukin-1 receptor antagonist (IL-1ra) on AIDS-Kaposi's sarcoma (AIDS-KS). Previous research has suggested that HIV-1 may induce KS directly through viral protein(s) or...

Patents deemed essential to next generation of cures.(statement in favor of gene patents)
May 29, 1995... Carl B. Feldbaum, president of the Biotechnology Industry Organization (BIO), issued the following statement in response to a call for an end to gene patents by the Joint Appeal Against Human and Animal Patenting, a coalition of religious...

Red Cross says infected blood came from U.S. prison.
May 29, 1995... In an investigation into how more than 11,000 Canadians contacted HIV and hepatitis C in the 1980s, Red Cross officials revealed that during that time the agency unwittingly bought blood from a prison in Arkansas. Canadian health officials...

Serology testing for TB not feasible in HIV endemic areas.
May 29, 1995... Serology testing for the diagnosis of tuberculosis (TB) is not feasible in areas that are HIV endemic, according to a report from Tanzania. Serology for the diagnosis of TB has a long record in TB literature and has been widely studied. The...

Branched DNA assay may be useful for monitoring disease.
May 29, 1995... The use of a branched DNA (bDNA) for the quantitation of HIV-1 RNA in plasma of patients infected with HIV-1 may be a useful method to monitor disease progression and therapeutic response, researchers indicated. The bDNA signal amplification...

Retroviral vector system has potential for targeted virus prevention.(HIV/Gene Therapy)
May 29, 1995... The HIV-1 based retroviral system has the potential for preventing the transmission of HIV-1 in susceptible cells. In addition, features of this particular vector system have been exploited to deliver and express anti-HIV therapeutics in...

HIV-specific CTL patterns suggest vaccine strategies.(cytotoxic T-lymphocytes)
May 29, 1995... Different patterns of HIV-specific cytotoxic T-lymphocyte response can be seen after primary infection with HIV, suggesting potential vaccine strategies. High levels of viremia during primary HIV infection have not been correlated with any...

Response seen in PBMCs of those immunized with HIV immunogen.(peripheral blood mononuclear cells)
May 29, 1995... A treatment-associated autoproliferative response was observed in the peripheral blood mononuclear cells of subjects immunized with a gp120-depleted inactivated HIV-1 Immunogen. "The data presented here appear to indicate that this...

IMF and World Bank policies may have contributed to spread of HIV.(International Monetary Fund)
May 29, 1995... The International Monetary Fund (IMF) and the World Bank have created social and economic forces that may have contributed to the spread of HIV infection in developing countries, according to a University of California San Francisco (UCSF)...

Tuberculosis highlights international lung meeting.
May 29, 1995... Scientific abstracts presented at an international conference show increasing concern about drug resistant tuberculosis (TB), as well as TB in major urban centers. Those findings were reported at the American Thoracic Society/American Lung...

PGE-2 involved in reduced toxoplasmastatic activity.(prostaglandin E-2)(Opportunistic Infections)
May 29, 1995... Prostaglandin E[2] (PGE[2]) is involved in the reduced toxoplasmastatic activity of monocytes and monocyte-derived macrophages from AIDS patients. In earlier studies Frans Delemarre and colleagues demonstrated that monocytes and...

Response to vaccines greatest soon after HIV conversion.
May 29, 1995... Immunization of HIV-infected adults with pneumococcal vaccine and Haemophilus influenzae Type B vaccine is most effective when conducted soon after seroconversion, according to a multicenter study. The U.S. Centers for Disease Control and...

Trimethoprim toxicities dose related in patients with PCP.(Pneumocystis carinii pneumonia)
May 29, 1995... Trimethoprim-related toxicities including anemia, neutropenia, and azotemia appeared to be dose related in a trial assessing its use along with sulfamethoxazole and atovaquone in AIDS patients with Pneumocystis carinii pneumonia....

DDI can be well tolerated for more than 4 years.(didanosine)
May 29, 1995... Didanosine (ddI) can be given to AIDS patients for more than four years, according to a five-year follow-up study from the U.S. National Institutes of Health. Several pilot studies have shown that elevations in CD4 cell counts lasting a year...

Hepatobiliary disorders in HIV patients.(Research Report)(Abstract)
May 29, 1995... According to an abstract submitted by the authors to the 7th European Congress of Clinical Microbiology and Infectious Diseases, held March 26-30, 1995, in Vienna, Austria, "We evaluate hepatobiliary complications and serological markers in...

Pulmonary tuberculosis in HIV infected patients: clinical forms and immunosuppression level.(Research Report)(Abstract)
May 29, 1995... According to an abstract submitted by the authors to the 7th European Congress of Clinical Microbiology and Infectious Diseases, held March 26-30, 1995, in Vienna, Austria, "PURPOSE: To determine the relationship between immunosuppression...

Antibodies to hepatitis B virus, hepatitis C virus and to human immunodeficiency virus in drug addicts and male homosexuals in Cracow.(Research Report)(Abstract)
May 29, 1995... According to an abstract submitted by the authors to the 7th European Congress of Clinical Microbiology and Infectious Diseases, held March 26-30, 1995, in Vienna, Austria, "The route of transmission of human immunodeficiency virus (HIV),...

Mapping of therapy-induced antibodies to interferon-alpha 2.(Research Report)(Abstract)
May 29, 1995... According to an abstract submitted by the authors to the 4th International Conference on Human Antibodies and Hybridomas, held April 26-28, 1995, in Amsterdam, The Netherlands, "Human interferon alpha-2 (IFN(alpha)2) has been approved for...

Helicobacter pylori associated gastritis in patients with AIDS.(Research Report)(Abstract)
May 29, 1995... According to an abstract submitted by the authors to the 7th European Congress of Clinical Microbiology and Infectious Diseases, held March 26-30, 1995, in Vienna, Austria, "PURPOSE: To evaluate the prevalence of H. pylori gastric infection...

Cyclosporiasis during AIDS, a case report.(Research Report)(Abstract)
May 29, 1995... According to an abstract submitted by the authors to the 7th European Congress of Clinical Microbiology and Infectious Diseases, held March 26-30, 1995, in Vienna, Austria, "Cyclospora species have been described in association with diarrheal...

Symptomatic and asymptomatic extraintestinal microsporidiosis in AIDS patients.(Research Report)(Abstract)
May 29, 1995... According to an abstract submitted by the authors to the 7th European Congress of Clinical Microbiology and Infectious Diseases, held March 26-30, 1995, in Vienna, Austria, "Microsporidia of the genera Enterocytozoon, Encephalitozoon and...

Tuberculous meningitis in HIV infected patients.(Research Report)
May 29, 1995... According to an abstract submitted by the authors to the 7th European Congress of Clinical Microbiology and Infectious Diseases, held March 26-30, 1995, in Vienna, Austria, "Within the June 1986-June 1993 period, 80 HIV infected patients with...

P24 antigen detection, viral isolation, DNA-PCR and in vitro antibody production for the diagnosis of HIV-1 latent infection in heterosexual women at high risk for HIV-1 infection.(reprinted from Genitourinary Medicine, April 1995)(Periodical Report)(Abstract)
May 29, 1995... According to the authors' abstract of an article published in Genitourinary Medicine, "INTRODUCTION: The report of the existence of at-risk seronegative subjects, latently infected with HIV-1 and producing 'in vitro' HIV-1 specific antibodies,...

Tuberculosis in Africans hospitalized in Paris - impact of human immunodeficiency virus infection.(reprinted form Presse Medicale, April 1, 1995)(Periodical Report)(Abstract)
May 29, 1995... According to the authors' abstract of an article published in Presse Medicale, "OBJECTIVES: Human immunodeficiency virus (HIV) infection has greatly modified the epidemiology and clinical course of tuberculosis. The aim of this study was to...

Inhibition of HIV-1 Tat-mediated LTR transactivation and HIV-1 infection by anti-Tat single chain intrabodies.(intracellular antibodies)(reprinted from EMBO Journal, April 3, 1995)(Periodical Report)(Abstract)
May 29, 1995... According to the authors' abstract of an article published in EMBO Journal, "Genes encoding the rearranged immunoglobulin heavy and light chain variable regions of anti-HIV-1 Tat, exon 1 or exon 2 specific monoclonal antibodies have been used...

Effects of the Th-1 and Th-2 stimulatory cytokines interleukin-12 and interleukin-4 on human immunodeficiency virus replication.(reprinted from Blood, April 15, 1995)(Periodical Report)(Abstract)
May 29, 1995... According to the authors' abstract of an article published in Blood, "The cytokines interleukin-12 (IL-12) and IL-4 play important roles in the development of Th-1-like (type-1) and Th-2-like (type-2) T-cell responses, respectively, and there...

Neurosyphilis in HIV-positive and HIV-negative patients: neuroimaging findings.(reprinted from American Journal of Neuroradiology, April 1995)(Periodical Report)(Abstract)
May 29, 1995... According to the authors' abstract of an article published in American Journal of Neuroradiology, "PURPOSE: To evaluate and describe the neuroimaging findings of patients with neurosyphilis. METHODS: The neuroimaging studies of 35 patients...

Comparison of zidovudine and zidovudine-thymostimulin in the long-term treatment of patients with asymptomatic human immunodeficiency virus infection and persistent generalized lymphadenopathy.(reprinted from Current Therapeutic Research - Clinical and Experimental, April 1995)(Periodical Report)(Abstract)
May 29, 1995... According to the authors' abstract of an article published in Current Therapeutic Research - Clinical and Experimental, "Given the positive results of the TP1-AZT Multicenter Study (TAMS), a second stage of the study was undertaken. The goal...

Anti-(human immunodeficiency virus) activity of polyoxotungstates and their inhibition of human immunodeficiency virus reverse transcriptase.(reprinted from Biochemical Journal, April 1, 1995)(Periodical Report)(Abstract)
May 29, 1995... According to the authors' abstract of an article published in Biochemical Journal, "Heteropolyoxotungstates of the Keggin class containing different heteroatoms were tested for inhibition of two strains of human immunodeficiency virus 1...

HIV particle may directly modulate immunity.
May 22, 1995... Proteins from some retroviruses - including HIV and cancer-associated HTLVs - can downregulate the types of immune responses that are most effective against viral infections. This immunomodulatory activity requires only a relatively small...

Antigen reduction plus IL-12 switches immune response, cures chronic infection.
May 22, 1995... An ineffective T-helper-cell type 2 (Th2) immune response can be switched to a curative T-helper-cell type 1 (Th1) immune response by drug-induced reduction of antigenic load and treatment with interleukin 12 (IL-12), mouse studies show. The...

Study shows ddI active in small doses for those who are AZT intolerant. (didanosine, zidovudine)
May 22, 1995... Patients with very advanced HIV disease who are intolerant of zidovudine may respond favorably to didanosine (ddI), but daily doses of 750 mg or more could induce unacceptable toxicity. Researchers in Germany found that ddI doses as low as...

Inhibitors of reverse transcription.
May 22, 1995... Researchers from France stated they have shown that chimeric (alpha)(beta) oligonucleotides can inhibit reverse transcription. Claudine Boiziau, INSERM, Bordeaux, France, and colleagues said that they synthesized alpha-beta chimeric 17-mer...

HIV vaccine trial volunteer becomes infected.
May 22, 1995... A volunteer in an AIDS vaccine clinical trial became infected with HIV four and a half months after receiving a final injection, according to a report from San Francisco General Hospital. The man became infected through homosexual sex after...

Doctors hope to battle AIDS by rebuilding immune systems.
May 22, 1995... Doctors in Missouri are planning a way to treat people with AIDS by rebuilding their battered immune systems. Doctors at Cardinal Glennon Children's Hospital are in the early stages but should finish basic research in a year. If the...

IL-12 and IL-4 stimulated HIV replication inhibited by dideoxynucleosides. (interleukin)
May 22, 1995... Interleukin-12 (IL-12) and IL-4 can stimulate HIV replication by T cells and HIV-induced cytopathicity of the CD4(+) T-cell subset, researchers report. The observations may have significant implications for the pathogenesis of HIV...

531 AIDS cases in China detected in 1994.
May 22, 1995... HIV tightened its grip on China in 1994, with authorities detecting 531 new cases compared with a total of 1,241 in the previous nine years, the official media said. "The spread of [HIV] has quietly accelerated, with new cases in 1994 making...

Improved prophylaxis against PCP "urgently needed." (Pneumocystis carinii pneumonia)
May 22, 1995... There is an urgent need to identify improved methods of prophylaxis against Pneumocystis carinii pneumonia (PCP) in severely immunosuppressed AIDS patients, according to a report from Baltimore's Johns Hopkins University. In this study...

Oral ganciclovir adequate for CMV maintenance therapy. (cytomegalovirus)
May 22, 1995... Oral ganciclovir is an adequate alternative to intravenous ganciclovir in maintenance therapy of HIV-positive persons with cytomegalovirus, according to a report from the Oral Ganciclovir European and Australian Cooperative Study Group (OGEAC)....

HIV symptoms not always obvious.
May 22, 1995... Contrary to widespread belief, children infected with HIV at birth may live for years without symptoms and without anyone even realizing they are infected, researchers say. When such youngsters get sick, doctors may fail to recognize the...

Prevention strategies in developing countries complicated.
May 22, 1995... Decisions about preventive tuberculosis (TB) therapy in HIV-infected persons living in developing countries require a balance of the needs of the individual and those of TB control at a public health level, according to a study from the London...

Testing for TB along with HIV good idea. (tuberculosis)
May 22, 1995... Screening for tuberculosis (TB) at HIV-testing sites may be an effective approach to early detection of active disease among both HIV-positive and HIV-negative persons, according to a report from the Dominican Republic. In an effort to...

Majority of HIV+ in U.S. tested late in infection.
May 22, 1995... The majority of persons with AIDS in the United States are tested late in their course of HIV infection, according to a U.S. Centers for Disease Control and Prevention (CDC) report. Determining at what point in the course of HIV infection...

3TC has good activity in mildly symptomatic HIV+. (lamivudine)
May 22, 1995... The nucleoside analog lamivudine (3TC) may have significant antiretroviral activity in patients with asymptomatic or mildly symptomatic HIV infection. Over the past few years, novel nucleoside analogs have been described that may improve...

Resistance in HIV+ stable in Malawi despite general increase.
May 22, 1995... A lack of increase in drug resistance among HIV-positive tuberculosis (TB) patients in Malawi, despite an overall increase in TB incidence, is encouraging for TB control programs. Recent World Health Organization (WHO) recommendations...

Viral hepatitis, tuberculosis, HIV and leprosy in immigrants.(Research Report)
May 22, 1995... According to an abstract submitted by the authors to the 7th European Congress of Clinical Microbiology and Infectious Diseases, held March 26-30, 1995, in Vienna, Austria, "OBJECTIVE: To evaluate the incidence of transmissible diseases in the...

Clinical presentation of tuberculosis and MAI disease in patients with HIV infection: a comparative analysis of 88 hospital cases. (Mycobacterium avium-intracellulare)(Research Report)
May 22, 1995... According to an abstract submitted by the authors to the 7th European Congress of Clinical Microbiology and Infectious Diseases, held March 26-30, 1995, in Vienna, Austria, "OBJECTIVES AND METHODS: To compare the clinical features of...

Fungal and bacterial urinary tract infections (UTI) in HIV infected patients.(Research Report)
May 22, 1995... According to an abstract submitted by the authors to the 7th European Congress of Clinical Microbiology and Infectious Diseases, held March 26-30, 1995, in Vienna, Austria, "OBJECTIVE: This study was carried out in order to investigate...

Immune disorders impact on the course of disease in patients with destructive lung tuberculosis.(Research Report)
May 22, 1995... According to an abstract submitted by the author to the 7th European Congress of Clinical Microbiology and Infectious Diseases, held March 26-30, 1995, in Vienna, Austria, "The aim of the work was to prove the impact of systemic immune...

Extrapulmonary tuberculosis: experiences from a university hospital (1985-1993).(Research Report)
May 22, 1995... According to an abstract submitted by the authors to the 7th European Congress of Clinical Microbiology and Infectious Diseases, held March 26-30, 1995, in Vienna, Austria, "To study the characteristics of extrapulmonary tuberculosis (ET) in...

Trends in morbidity and mortality in a cohort of patients with AIDS: Rome 1985-1993.(Research Report)
May 22, 1995... According to an abstract submitted by the authors to the 7th European Congress of Clinical Microbiology and Infectious Diseases, held March 26-30, 1995, in Vienna, Austria, "OBJECTIVES: to assess trends in morbidity and mortality in a cohort...

Effect of a BCG vaccination on viral replication and env gene variability in HIV-2 SBL-infected monkeys.(Research Report)
May 22, 1995... According to an abstract submitted by the authors to the 7th European Congress of Clinical Microbiology and Infectious Diseases, held March 26-30, 1995, in Vienna, Austria, "OBJECTIVE: Understanding the effect induced by a stimulation of the...

Immune predispositions for cytomegalovirus retinitis in AIDS. (reprinted from the Journal of Clinical Investigation, April 1995)(Periodical Report)(Abstract)
May 22, 1995... According to the authors' abstract of an article published in Journal of Clinical Investigation, "CMV retinitis develops in similar to 28-35% of all AIDS patients at later stages of disease, often leading to blindness. To determine whether the...

A newly developed immunofluorescence assay for simultaneous detection of antibodies to human immunodeficiency virus type 1 and type 2. (reprinted from the Journal of Virological Methods, April 1995)(Periodical Report)(Abstract)
May 22, 1995... According to the authors' abstract of an article published in Journal of Virological Methods, "Immunofluorescence assays (IFA) that simultaneously distinguish between antibodies against closely related human immunodeficiency virus type 1...

Effect of combination chemotherapy with cisplatin and cyclophosphamide on human immunodeficiency virus type-1 surrogate markers in a patient with advanced epithelial ovarian cancer. (reprinted from Gynecologic Oncology, April 1995)(Periodical Report)(Abstract)
May 22, 1995... According to the authors' abstract of an article published in Gynecologic Oncology, "This is the first report to evaluate the effects of combination chemotherapy on HIV-1 surrogate markers in an HIV-1-infected patient with an advanced...

Cross-protective immune responses induced in rhesus macaques by immunization with attenuated macrophage-tropic simian immunodeficiency virus. (reprinted from the Journal of Virology, May 1995)(Periodical Report)(Abstract)
May 22, 1995... According to the authors' abstract of an article published in Journal of Virology, "The simian immunodeficiency virus (SIV) macaque model of AIDS has provided a valuable system with which to investigate vaccine approaches for protection against...

Induction by human immunodeficiency viruses types 1 and 2 of degradation of CD4 but not of a CD4 mutant unable to bind viral envelope glycoproteins. (reprinted from the Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, April 15, 1995)(Periodical Report)(Abstract)
May 22, 1995... According to the authors' abstract of an article published in Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, "HIV-1 appears to use a multiple gene strategy to regulate CD4 receptor expression, which emphasizes the...

Cytokines from activated T cells induce normal endothelial cells to acquire the phenotypic and functional features of AIDS Kaposi's sarcoma spindle cells. (reprinted from the Journal of Clinical Investigation, April 1995)(Periodical Report)(Abstract)
May 22, 1995... According to the authors' abstract of an article published in Journal of Clinical Investigation, "Kaposi's sarcoma (KS) is a proliferative disease of vascular origin particularly frequent in HIV-1-infected homosexual men (AIDS-KS) and...

Effects of interleukin-1 and interleukin-1 receptor antagonist in AIDS-Kaposi's sarcoma. (reprinted from the Journal of Acquired Deficiency Syndromes and Human Retrovirology, April 15, 1995)(Periodical Report)(Abstract)
May 22, 1995... According to the authors' abstract of an article published in Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, "Kaposi's sarcoma (KS) is the most common tumor seen in patients with HIV-1 infection. HIV-1 may induce KS...

Small volume bronchoalveolar lavage used in diagnosing Pneumocystic carinii pneumonia in HIV-infected patients. (reprinted from Chest, April 1995)(Periodical Report)(Abstract)
May 22, 1995... According to the authors' abstract of an article published in Chest, "To determine the volume of bronchoalveolar lavage (BAL) fluid necessary to diagnose Pneumocystis carinii pneumonia (PCP) in immunocompromised patients, specimens from 25...

Pentamidine aerosol versus trimethoprim-sulfamethoxazole for Pneumocystic carinii in acquired immunodeficiency syndrome. (reprinted from the American Journal of Respiratory and Critical Care Medicine, April 1995)(Periodical Report)(Abstract)
May 22, 1995... According to the authors' abstract of an article published in American Journal of Respiratory and Critical Care Medicine, "Pneumocystis carinii pneumonia remains one of the most common opportunistic infections in patients with acquired immune...

Carboxanilide derivative non-nucleoside inhibitors of HIV-1 reverse transcriptase interact with different mechanistic forms of the enzyme. (reprinted from Biochemistry, April 4, 1995)(Periodical Report)(Abstract)
May 22, 1995... According to the authors' abstract of an article published in Biochemistry, "Researchers at the National Cancer Institute first recognized the anti-HIV potential of the carboxanilide compound oxathiin carboxanilide (UC84) [Bader, J.P., et al....

Rates of mother-to-child transmission of HIV-1 in Africa, America, and Europe: results from 13 perinatal studies. (reprinted from the Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, April 15, 1995)(Periodical Report)(Abstract)
May 22, 1995... According to the authors' abstract of an article published in Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, "The goal of this exercise was to provide estimates of the mother-to-child transmission rate (TR) of human...

Adaptation of human immunodeficiency virus type 1 to cells expressing a binding-deficient CD4 mutant (lysine 46 to aspartic acid). (reprinted from the Journal of Virology, May 1995)(Periodical Report)(Abstract)
May 22, 1995... According to the authors' abstract of an article published in Journal of Virology, "Human immunodeficiency virus (HIV-1) was adapted to replicate efficiently in cells expressing an altered form of the CD4 viral receptor. The mutant CD4 (46...

Mother-to-child HIV occurs late in pregnancy.
May 15, 1995... The frequency of early in utero HIV infection appears to be low, compared with transmission rates in infants born to HIV-1-infected mothers, suggesting that transmission occurs mostly later in pregnancy or at delivery, according to a report...

Specific risk factors associated with extrapulmonary TB. (tuberculosis)
May 15, 1995... Factors such as injecting drug use, prison record or residence in high TB-endemic areas are associated with extrapulmonary presentation in AIDS patients with tuberculosis. In 1987 the U.S. Centers for Disease Control and Prevention (CDC)...

Plastic condoms fail bedroom test. (Avanti condoms)
May 15, 1995... A plastic condom approved by the U.S. Food and Drug Administration (FDA) has been sent back for more testing. The condom, which is recommended only for people who are allergic to latex, was approved for sale by the FDA in 1991, but new data...

HPLC with fluorescence identifies M. tuberculosis. (high-performance liquid chromatography, Mycobacterium tuberculosis)
May 15, 1995... Texas researchers report the identification of Mycobacterium tuberculosis and Mycobacterium avium complex directly from smear-positive sputum specimens and BACTEC 12B cultures by high-performance liquid chromatography with fluorescence...

15 percent of HIV-infected men will be long-term survivors.
May 15, 1995... HIV-infected individuals whose CD4(+) T-cell counts do not decline in the first years of infection are very likely to be long-term survivors, according to a new analysis of data from the Multicenter AIDS Cohort Study (MACS). The analysis...

HIV isolates sensitive to IFN early in infection. (interferon)
May 15, 1995... Before progression to AIDS primary isolates of HIV-1 are sensitive to inhibition with interferon-(alpha), suggesting that interferon therapy can be effective in decreasing viral load, according to a report from Baltimore's Johns Hopkins...

Leader region of HIV-1 genomic RNA inhibits HIV-1 expression.
May 15, 1995... Regarding potential gene therapy for the treatment of HIV-1 infections, researchers from The Netherlands suggested that leader-encoded functions can be used to inhibit HIV expression. Ben Berkhout and Jeroen L.B. van Wamel, University of...

More females becoming infected with HIV.
May 15, 1995... Increasingly, the faces of AIDS in Arkansas belong to women and teenage girls. Nearly a quarter of Arkansas' newly diagnosed HIV-positive patients are women, representing a "very sad, alarming increase" in the spread of HIV among...

Study with HGP--30 AIDS vaccine moves into phase I/II.
May 15, 1995... CEL-SCI Corporation, Alexandria, Virginia, "is now undertaking the second segment of a clinical study with our potential AIDS vaccine, HGP-30, whereby we will revaccinate about 15 HIV-negative individuals who were injected three to four years...

Results from anti-HIV drug AG1343 study reported.
May 15, 1995... Agouron Pharmaceuticals Inc., La Jolla, California, reported encouraging preliminary results from a pilot Phase II clinical study of the company's anti-HIV drug AG1343. At a meeting of the International Society of Antiviral Research in Santa...

FDA approval for herpes simplex virus diagnostic test. (Enzyme Linked Virus Inducible System HSV Test Kit)
May 15, 1995... Diagnostic Hybrids Inc. (DHI), Athens, Ohio, announced that the U.S. Food and Drug Administration (FDA) has approved for marketing its Enzyme Linked Virus Inducible System (ELVIS) HSV Test Kit for in vitro diagnostic use in identification of...

Placental hormone may help treat KS. (Kaposi's sarcoma)
May 15, 1995... A hormone found in pregnant women may be useful for treating Kaposi's sarcoma (KS), researchers report. The hormone killed KS cells in the laboratory, and in mice it shrank tumors caused by injections of KS cells, Dr. Robert Gallo said....

AIDS patients with Mac may be infected with different strains. (Mycobacterium avium)
May 15, 1995... AIDS patients with polyclonal Mycobacterium avium infection may be infected simultaneously with strains that differ significantly in their antimicrobial susceptibilities. Organisms of the Mycobacterium avium complex (MAC) are the most common...

Unclear whether prophylaxis or treatment better for MAC. (Mycobacterium avium complex)
May 15, 1995... It remains unclear whether prophylaxis is preferable to active surveillance and aggressive treatment of early infection in AIDS patients with Mycobacterium avium complex (MAC), according to a review by a Vanderbilt University researcher....

Cytokine-mediated responses not cause of chronic diarrhea.
May 15, 1995... Mucosal cytokine-mediated inflammatory responses do not play an important role in the pathogenesis of different types of diarrhea in HIV-infected patients, according to a report from The Netherlands. Researcher Fransje Snjders and colleagues...

Medical marijuana bill passes first test.
May 15, 1995... California patients with AIDS, cancer and other serious medical conditions would be allowed to use marijuana to ease their pain under a bill approved by a legislative committee. The Assembly Public Safety Committee backed a measure by...

Research to prevent STDs in women announced. (sexually transmitted diseases)
May 15, 1995... The U.S. National Institute of Allergy and Infectious Diseases (NIAID) has launched three new research projects on topical microbicides to prevent and control the spread of sexually transmitted diseases (STDs), including AIDS, in women....