AIDS Weekly articles from March 1992

AIDS Weekly archives from March 1992

CD4 decline slower in drug users than other HIV+ risk groups. (Johns Hopkins University)
March 30, 1992... Johns Hopkins University Contrary to what researchers expected, a large-scale study of active intravenous drug users in Baltimore, Maryland, showed that this population had a slower rate of decline in T cells than homosexual men in San...

Agency head discusses AIDS drug research. (Dr. David A. Kessler) (U.S. Food and Drug Administration)
March 30, 1992... U.S. FDA Calling his agency the "most pro-consumer protection agency in the world," U.S. Food and Drug Administration (FDA) Commissioner Dr. David A. Kessler detailed the FDA's responsibilities and efforts to speed approval for...

New appointments to end biotech bottleneck. (Kathryn Zoon to head the Center for Biologics Evaluation and Research) (U.S. Food and Drug Administration)
March 30, 1992... U.S. FDA In response to criticism that his agency obstructs approval of biotech products, U.S. Food and Drug Administration (FDA) chief David Kessler has announced a new director - and 50 new scientific posts - for the Center for...

AIDS summit to shift focus to Third World concerns. (Amsterdam, The Netherlands)
March 30, 1992... Amsterdam, The Netherlands In a shift of focus, the VIII International Conference on AIDS, to be held July 19-24, 1992, will look into the problems faced in developing countries and on the need for more solidarity with their plight....

Clinical researchers meet to discuss latest in human health research. (conference of the Association of American Physicians, the American Society for Clinical Investigation, and the American Federation for Clinical Research) (Maryland)
March 30, 1992... Maryland More than 4,000 clinical investigators from across the United States will gather at the Baltimore Convention Center May 1-4, 1992, to hear the latest in human health research at the national "clinical research meetings." ...

Donor eligibility rules revised. (blood donors) (American Red Cross)
March 30, 1992... American Red Cross Removing the upper age limit for giving blood and requiring prospective donors to know the exact name of any prescription medication they may have taken within 30 days are among several changes in Red Cross...

Testing to detect HIV-2 begun. (testing donated blood) (Ohio)
March 30, 1992... Ohio The American Red Cross has begun testing all donated blood for HIV-2. The Red Cross blood services division for central Ohio began March 16, 1992, to use a new test that detects HIV-1 and the less prevalent HIV-2 strain. ...

Massive TB outbreak hits North Central Bronx Hospital. (tuberculosis) (New York)
March 30, 1992... New York A massive tuberculosis outbreak has been reported at North Central Bronx Hospital (NCBH), with over 60 healthcare workers testing positive thus far. The outbreak occurred in the 2C clinic and several medical wards (9A, 9B,...

Country is slow to tackle AIDS epidemic. (Pakistan)
March 30, 1992... Pakistan Pakistan has been slow to tackle a looming AIDS epidemic that is poised to devastate some Asian countries. While the numbers are still deceptively low -officially only 82 - experts warn that the affected population could run...

Tourism seen as risk factor in war on AIDS. (Gambia)
March 30, 1992... Gambia Although tourism could be a risk factor in spreading AIDS, medical authorities in Gambia are against the idea of screening visitors. "I cannot subscribe to this view," says Dr. Kabir Cham, who until recently was manager of the...

Hospitals in Bombay not admitting AIDS patients. (India)
March 30, 1992... India Hospitals in the western Indian metropolis of Bombay are closing their doors on patients found infected by HIV, the Times of India newspaper reported. Some hospitals are compulsorily screening all patients for signs of HIV...

No change of attitudes in "AIDS capital." (Mombasa, Kenya )
March 30, 1992... Kenya The lure of quick money and, sometimes, the hope of lifelong security as a tourist's "long distance" mistress has made the port city of Mombasa Kenya's "AIDS capital." Coast province, of which Mombasa is the capital, had more...

Campaign centers on safe sex as men shun condoms. (Jamaica)
March 30, 1992... Jamaica With AIDS seizing most of the attention, the incidence of other sexually transmitted diseases (STDs) has been growing almost unnoticed in Jamaica. This STD increase, coupled with the steady rise in the number of known AIDS...

Women and children carry the burden of AIDS. (South Africa)
March 30, 1992... South Africa Given the shame and secrecy surrounding AIDS, women infected with HIV in South Africa are too afraid to talk about it with their partners. HIV-positive women fear being abandoned and laughed at if they told their...

Approval for birth control pills rejected, AIDS fear cited. (Japan)
March 30, 1992... Japan The Japanese government refused to ease its strict control on birth control pills, fearing AIDS could spread if oral contraceptives reduced condom use. Pharmaceutical firms had expected approval to sell low-dosage birth control...

AIDS spreading in Kerala, Punjab. (India)
March 30, 1992... India An alarmingly large number of AIDS cases has been detected in India's northwestern state of Punjab and the southern coastal state of Kerala. Of the 27 cases reported so far in Punjab, 25 of the patients have died, according to...

Most teens having sex don't use condoms. (U.S. Centers for Disease Control)
March 30, 1992... U.S. CDC Four in 10 teenagers have had sex in the past three months and half of them didn't use a condom, increasing their danger of hepatitis B infection, according to a recent survey by the U.S. Centers for Disease Control (CDC). ...

Organization distributes $470,000 to 51 chapters of ACT-UP. (AIDS Coalition To Unleash Power) (Physicians Association for AIDS Care)
March 30, 1992... Physicians Association for AIDS Care The Physicians Association for AIDS Care (PAAC), Chicago, Illinois, recently distributed $470,000 in grants to 51 chapters of AIDS Coalition To Unleash Power (ACT-UP). The funding represented a...

Agency clears QC-Hepatitis product for marketing. (QC-Hepatitis Quality Assurance Reagent for hepatitis testing of blood supply & blood products) (U.S. Food and Drug Administration)
March 30, 1992... U.S. FDA North American Biologicals Inc. (NABI) announced that its QC-Hepatitis Quality Assurance Reagent for in vitro diagnostic use has been cleared for commercial distribution by the U.S. Food and Drug Administration (FDA). ...

Identification of amino acid residues at the binding site of HIV-1 reverse transcriptase for the non-nucleoside inhibitor nevirapine. (Research Report)
March 30, 1992... AUTHORS: R.H. Ingraham, J.C. Wu, J. Hopkins, D.E.H. Palladino, R.M. House, K.A. Cohen, J. Adams, P.R. Farina and Peter M. Grob. Boehringer Ingelheim Pharmaceuticals lnc., Ridgefield, Connecticut. According to an abstract submitted by...

Reactivity of cysteine residues in the HIV-1 protease. (Research Report)
March 30, 1992... AUTHORS: Anders R. Karlstrom, Brian D. Shames and Rodney L. Levine. Laboratory of Biochemistry, National Heart, Blood and Lung Institute, U.S. National Institutes of Health, Bethesda, Maryland. According to an abstract submitted by...

A new serine protease in T4+ lymphocyte membrane, tryptase TL2, is a novel binding protein of HIV-1, gp120. (Research Report)
March 30, 1992... AUTHORS: N. Katunuma, A. Fukutomi and H. Kido. Institute for Enzyme Research, University of Tokushima, Tokushima, Japan. According to an abstract submitted by the authors to the joint meeting of the American Society for Biochemistry...

Spectroscopic evidence of a zinc finger in HIV-1 integrase. (Research Report)
March 30, 1992... AUTHORS: G. Sanyal(1), C.J. Burke(1), M.W. Bruner(1), R.L. Lafemia(2), H. Robbins(2), A.S. Zeft(2), C.R. Middaugh(1) and M.S. Cordingley(2). (1)Department of Pharmaceutical Research and (2)Department of Virus and Cell Biology. Merck,...

Template/primer interactions with recombinant forms of HIV-1 reverse transcriptase. (Research Report)
March 30, 1992... AUTHORS: W.A. Beard. A. Kumar and S.H. Wilson. Laboratory of Biochemistry, U.S. National Cancer Institute, U.S. National Institutes of Health, Bethesda, Maryland. According to an abstract submitted by the authors to the joint...

RNA double helix unwinding by recombinant HIV-1 nucleocapsid (NC) protein. (Research Report)
March 30, 1992... AUTHORS: Raza Khan and David P. Giedroc. Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas. According to an abstract submitted by the authors to the joint meeting of the American Society for...

Molecular and immunophenotypic characterization of AIDS-associated, Epstein-Barr virus-negative, polyclonal lymphoma. (Periodical Report)
March 30, 1992... SOURCE: Journal of Clinical Oncology, March, 1992;10(3):383-389. Epstein-Barr virus (EBV)-negative, AIDS-associated, polyclonal B-cell lymphoma appears to be a new class of HIV-associated disease, according to a report from the...

Inhibition of development of Kaposi's sarcoma-related lesions by a bacterial cell wall complex. (sulfated polysaccharide-peptidoglycan compound) (Periodical Report)
March 30, 1992... SOURCE: Science, March 13, 1992;255(5050):1437-1440. A sulfated polysaccharide-peptidoglycan compound (SP-PG) produced by bacteria controls the growth of Kaposi's sarcoma (KS)-derived cells in vitro - at nontoxic concentrations - and...

"Identification of a major growth factor for AIDS-Kaposi's sarcoma cells as Oncostatin M," and "Oncostatin M as a potent mitogen for AIDS-Kaposi's sarcoma-derived cells." (summary of 2 articles) (Periodical Report)
March 30, 1992... SOURCE: Science, March 13, 1992;255(5050):1430-1432 and 1432-1434. Two research groups, working separately along different lines of investigation, have identified Oncostatin M as the long-sought Kaposi's sarcoma (KS) growth factor....

The IL-6 signal transducer, gp130: an Oncostatin M receptor and affinity converter for the LIF receptor. (leukemia inhibitory factor) (Periodical Report)
March 30, 1992... SOURCE: Science, March 13, 1992;255(5050):1434-1437. A portion of the cellular interleukin-6 (IL-6) receptor binds Oncostatin M (OSM) with high affinity, report Immunex Corporation researchers David P. Gearing and colleagues. ...

HP-16-related DNA sequences in Kaposi's sarcoma. (human papillomavirus) (Periodical Report)
March 30, 1992... SOURCE: The Lancet, February 29, 1992;339:515-518. Human papilloma virus-16-related DNA sequences appear to be associated with different forms of Kaposi's sarcoma, and may have a role in the pathogenesis of this disease, according to a...

High frequency of latent and clinical human papillomavirus cervical infections in immunocompromised human immunodeficiency virus-infected women. (Periodical Report)
March 30, 1992... SOURCE: Obstetrics and Gynecology, March 1992;79(3):321-327. Human papillomavirus (HPV) is detectable - and is associated with more lesions and cervical neoplasms -more frequently in HIV-seropositive women with CD4 counts lower than...

Natural killer (NK) cell stimulatory factor increases the cytotoxic activity of NK cells from both healthy donors and human immunodeficiency virus-infected patients. (Periodical Report)
March 30, 1992... SOURCE: Journal of Experimental Medicine, March 1992;175(3):789-796. A newly discovered cytokine, interleukin-12 (IL-12) -also known as natural killer cell stimulatory factor (NKSF) - is a potential therapeutic agent for AIDS,...

Central nervous system dysfunction in SIV-infected monkeys mimics HIV infection. (U.S. National Institute of Mental Health)
March 23, 1992... U.S. National Institute of Mental Health Rhesus monkeys may hold the key to understanding the baffling neuropsychological impairments observed in people infected with HIV. Deficits in cognitive and motor function often occur early...

Polio vaccine spread SIV to humans, lawyer suggests. (Walter S. Kyle; live oral polio vaccine used for herpes treatment) (U.S. Bureau of Biologics)
March 23, 1992... U.S. Bureau of Biologics Even after simian type C RNA viruses were detected in lots of polio vaccine, the U.S. government allowed their use and unwittingly unleashed the AIDS epidemic, a lawyer proposes. Documents uncovered by...

Researcher develops possible forerunner to AIDS vaccine. (Dr. Hans Schreier) (University of Florida)
March 23, 1992... University of Florida An artificial viral envelope designed to mimic the protective covering around the human immunodeficiency virus could be a first step in developing an AIDS vaccine, a University of Florida (UF), Gainesville,...

Compound from soil stops Kaposi's sarcoma in lab mice. (sulfated polysaccharide peptidoglycan, or SP-PG) (U.S. National Cancer Institute)
March 23, 1992... U.S. NCI Laboratory studies in mice show that a compound from soil bacteria blocks the growth of Kaposi's sarcoma (KS). Researchers at the U.S. National Cancer Institute (NCI) report in the journal Science that a bacterial extract...

AIDS-related cancers on rise. (Moffitt Cancer Center)
March 23, 1992... Moffitt Cancer Center As antiviral therapy prolongs the lives of AIDS patients, physicians are beginning to see more lung and breast cancers not normally associated with these typically younger patients, said John C. Ruckdeschel, M.D.,...

Experiments suggest ozone loss may speed AIDS onset. (New Mexico)
March 23, 1992... New Mexico Preliminary results of experiments on mice suggest the depletion of the ozone layer in Earth's atmosphere may speed the onset of AIDS, researchers say. Lovelace Medical Foundation photobiologist Ronald Ley is directing a...

Oral delivery of medication proves successful. (Alva Corp.'s Mucosal Oral Therapeutic System for treatment of oral candidiasis) (University of California, San Francisco)
March 23, 1992... University of California, San Francisco A unique method of delivering a steady dose of medication in a patient's mouth over a long period of time proved more effective than a conventional method for treating an oral fungus, dental...

Oral diseases provide clues to development of AIDS. (California)
March 23, 1992... California The presence of salivary gland enlargement in HIV -infected men serves as a predictor of a less rapid progression to AIDS in those individuals than among those without the condition, according to a new study by researchers...

Dentists eligible for AIDS insurance. (Wisconsin)
March 23, 1992... Wisconsin Wisconsin and Missouri are the only states in which dentists can obtain AIDS insurance policies similar to those available to physicians, officials report. Benefits can be paid to medical professionals who test positive for...

Health officials report surges of hepatitis A in homosexual men. (U.S. Centers for Disease Control)
March 23, 1992... U.S. CDC U.S. health officials reported outbreaks of hepatitis A among homosexual men, who have not historically been at high risk for the viral liver disease. Researchers with the U.S. Centers for Disease Control (CDC) said they fear...

Hepatitis antibodies "high" in Sacramento area IV drug users. (California)
March 23, 1992... California A two-year University of California (UC), Davis, study of 585 intravenous (IV) drug users in the Sacramento area found more than 70 percent tested positive for antibodies to either hepatitis B or C viruses, leading...

3TC active against hepatitis B virus. (Biochem Pharma)
March 23, 1992... Biochem Pharma Biochem Pharma Inc., Montreal, Quebec, announced that the compound 3TC, which is currently in human clinical trials as a potential AIDS treatment, has been found active against the Hepatitis B virus. Scientists at...

Agency licenses Johnson & Johnson/Chiron hepatitis C virus test. (Ortho HCV 2.0 ELISA Test System) (U.D. Food and Drug Administration)
March 23, 1992... U.S. FDA The U.S. Food and Drug Administration (FDA) licensed a hepatitis C virus (HCV) test that will further improve the safety of the American blood supply by reducing the risk of transfusion-associated infections. The American...

New safety guidelines could make healthcare costlier. (Missouri)
March 23, 1992... Missouri Checkups and hospital stays may become more expensive because of new safety guidelines for healthcare workers, but officials say the rules offer greater protection to workers. Effective March 13, 1992, the U.S. Occupational...

State issues new TB guidelines for hospitals. (tuberculosis) (New York)
March 23, 1992... New York The New York state Health Department issued strict new guidelines for hospital workers aimed at stemming the spread of the tuberculosis (TB) epidemic in New York City. Spokeswoman Fran Tarleton said the department expects as...

Bill for testing accident cases for AIDS passes. (Florida )
March 23, 1992... Florida A bill passed in the Florida state legislature would allow hospitals to perfoorm HIV tests on emergency patients without informed consent if nonmedical good Samaritans were exposed to their blood while giving first aid. The...

New study will track women with AIDS. (Michigan)
March 23, 1992... Michigan More women show up at hospitals suffering from what seems like advanced pneummonia when the real culprit is undiagnosed AIDS, researchers say. Many doctors don't consider the disease when examining women patients, and there...

Agency receives amendment for Advanced Viral Research's IND application for reticulose. (Investigational New Drug) (U.S. Food and Drug Administration)
March 23, 1992... U.S. FDA Advanced Viral Research Corp., Miami, Florida, announced that the U.S. Food and Drug Administration (FDA) confirmed receipt of the company's amendment to itts Investigational New Drug (IND) Application regarding the company's...

Rifabutin treatment IND approved. (Investigational New Drug; Mycobutin) (Adria Laboratories)
March 23, 1992... Adria Laboratories Adria Laboratories announced that the U.S. Food and Drug Administration (FDA)) has approved a Treatment Investigational New Drug (IND) for rifabutin (Mycobutiin). Clinical trials have been conducted with...

Comparison of the structures of HIV reverse transcriptase and that of the Klenow fragment of DNA pol I bound to duplex DNA. (Research Report)
March 23, 1992... AUTHORS: T.A. Steitz, L. Kohlstaedt, J. Wang, J. Friedman, P. Rice and L. Beese. Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University, New Haven, Connecticut. According to an abstract...

Kinetics of sCD4 binding to cells expressing HIV-1 envelope glycoprotein. (Research Report)
March 23, 1992... AUTHORS: D.S. Dimitrov, K. Hillman, J. Manischewitz, R. Blumenthal and H. Golding. U.S. National Cancer Institute, U.S. National Institutes of Health, and Division of Virology, CBER, Food and Drug Administration, Bethesda, Maryland. ...

Isolation and characterization of polynucleotide binding regions of recombinant HIV-1 reverse transcriptase. (Research Report)
March 23, 1992... AUTHORS: S.H. Wilson, A. Kumar, P. Becerra, B.J. Lee and D. Hatfield. Laboratory of Biochemistry and Experimental Carcinogenesis, U.S. National Cancer Institute, U.S. National Institutes of Health, Bethesda, Maryland. According to an...

Intracellular diversion of envelope glycoprotein gp160 of human immunodeficiency virus to lysosomes for degradation. (Research Report)
March 23, 1992... AUTHORS: X. Lin, A. Dashti, R.F. Schinazi and J. Tang. Protein Studies Program, Oklahoma City, Oklahoma, and Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, VA...

Structure of the ribonuclease H domain of HIV-1 reverse transcriptase. (Research Report)
March 23, 1992... AUTHORS: D.A Matthews, Z. Hostomska, Z. Hostomsky and J. Davies. Agouron Pharmaceuticals, La Jolla, California. According to an abstract submitted by the authors to the joint meeting of the American Society for Biochemistry and...

Fucoidan, a sulfated algal polysaccharide, inhibits recombinant HIV reverse transcriptase activity in vitro. (Research Report)
March 23, 1992... AUTHORS: G.F. Clark, S.C. Oehninger and L.K. Moen. Department of Biochemistry and the Jones Institute for Reproductive Medicine, Eastern Virginia Medical School, Norfolk, Virginia, and the Department of Chemistry and Biochemistry, Old...

Elevated cortisol as potential co-factor in AIDS. (Research Report)
March 23, 1992... AUTHORS: A.T. Sapse. Cortisol Medical Research, Miami, Florida. According to an abstract of a paper submitted for presentation at the VIII International Conference on AIDS/III STD World Conference, to be held in Amsterdam, The...

Reconstruction and precision of HIV infection rates based on AIDS incidence data. (Research Report)
March 23, 1992... AUTHORS: N.P. Jewell, Ph.D. University of California, Berkeley, California. According to an abstract submitted by the authors to the joint meeting of the Eastern North American Region of the Biometric Society, American Statistical...

Estimating 1978-1990 and future HIV-1 seroconversions rates in subgroups of homosexual men. (Research Report)
March 23, 1992... AUTHORS: D.R. Hoover, A. Munoz, V. Carey et al. Johns Hopkins University, Baltimore, Maryland, for the Multicenter AIDS Cohort Study. According to an abstract submitted by the authors to the joint meeting of the Eastern North American...

Pooling blood sera to reduce cost and improve quality of HIV screening. (Research Report)
March 23, 1992... AUTHORS: M. Pagano, E. Litvak and X. Tu. Harvard University, Cambridge, Massachusetts. According to an abstract submitted by the authors to the joint meeting of the Eastern North American Region of the Biometric Society, American...

Design of yeast-secreted albumin derivatives for human therapy: biological and antiviral properties of a serum albumin-CD4 genetic conjugate. (Periodical Report)
March 23, 1992... SOURCE: Proceedings of the National Academy of Sciences, March 1, 1992;89(5):1904-1908. A genetically engineered CD4/human serum albumin (HSA) construct holds promise as an AIDS therapy, French researchers suggest. Rhone-Poulenc...

Progressive glomerulosclerosis and enhanced renal accumulation of basement membrane components in mice transgenic for human immunodeficiency virus type 1 genes. (Periodical Report)
March 23, 1992... SOURCE: Proceedings of the National Academy of Sciences, March 1, 1992;89(5):1577-1581. A renal syndrome frequently seen in HIV+ patients appears to be associated with the presence of HIV genes in kidney cells, an animal model for the...

Trichosanthin treatment of HIV-induced immune dysregulation. (Periodical Report)
March 23, 1992... SOURCE: European Journal of Clinical Investigation, February 1992;22(2):113-122. Treatment with trichosanthin - in the short term -improved CD4 counts and reduced PGL symptoms in patients with early-stage HIV disease enrolled in an...

HIV antibody testing in young, urban adults. (Periodical Report)
March 23, 1992... SOURCE: Archives of Internal Medicine, February 1992;152:(2):397-402. Fewer than half of people at risk for HIV infection seek testing for the virus, an anonymous survey indicates. D.C. Berrios and colleagues of the University of...

Inhibition of T-cell antigen receptor-dependent phosphorylation of CD4 in human immunodeficiency virus type-1 infected cells. (Periodical Report)
March 23, 1992... SOURCE: Journal of Biological Chemistry, February 25, 1992;267(6):4102-4109. HIV-associated disruption of T-lymphocyte function is apparently related to impaired phosphorylation of CD4 in infected cells. University of...

Transmission of tuberculosis to hospital workers by a patient with AIDS. (Periodical Report)
March 23, 1992... SOURCE: Chest, February 1992;101(2):581-582. Thirty healthcare workers tested positive for tuberculosis after exposure to an AIDS patient whose TB diagnosis was delayed. J.R. Pierce and colleagues of Texas Technical University...

Research organization responds to allegation of polio vaccine contamination. (theory that AIDS originated from a monkey retrovirus in Dr. Hilary Koprowski's oral polio vaccine) (Wistar Institute)
March 16, 1992... Wistar Institute The March 19, 1992, issue of Rolling Stone magazine contains an article by free-lance writer Tom Curtis claiming that an oral polio vaccine originally developed by former Wistar Institute Director Hilary Koprowski,...

Selection may favor emergence of infectious HIV strains. (Steven Wolinsky's research on mother-to-infant transmission of the human immunodeficiency virus) (Northwestern University)
March 16, 1992... Northwestern University During HIV replication within an infected individual, pressure from the immune system may result in selection of virus strains that are more infectious than the original virus. Northwestern University...

Agency urges aggressive efforts to control tuberculosis. (U.S. Centers for Disease Control)
March 16, 1992... U.S. CDC Tuberculosis has become a new disease entity, warn U.S. Centers for Disease Control (CDC) researchers who point to the rapid increase of tuberculosis cases and the dramatic emergence of drug-resistant strains of M....

Tuberculosis therapy compliance test approved. (Dynagen Inc.'s Mycodyn Uritec test strips) (U.S. Food and Drug Administration)
March 16, 1992... U.S. FDA Dynagen Inc., Cambridge, Massachusetts, announced it has received approval from the U.S. Food and Drug Administration (FDA) to market its Mycodyn Uritec test strips for tuberculosis (TB) therapy compliance. According to...

Topical alpha interferon formulation found 'useful modality' in treating genital herpes. (Interferon Sciences, Inc.)
March 16, 1992... Interferon Sciences, Inc. Interferon Sciences, Inc. (ISI) announced that the March 1992 issue of Antiviral Research reported promising results of a study of an investigational topical (dermatological) formulation of alpha interferon in...

Gallo under investigation again. (Robert Gallo) (U.S. National Institutes of Health)
March 16, 1992... U.S. NIH Dr. Robert Gallo is under investigation on suspicion of making false statements in applying for a HIV test patent, the New York Times reported. The inspector general of the Health and Human Services (HHS) Department,...

Dental oral examinations first step in determining HIV status. (Pennsylvania)
March 16, 1992... Pennsylvania Dentists may be the first to detect possible signs of HIV in a patient during a routine oral examination, the Philadelphia County Dental Society was told during the opening sessions of the 61st Annual Liberty Dental...

Researchers identify the types of oral lesions that occur among HIV-infected women. (University of California, San Francisco)
March 16, 1992... University of California, San Francisco Women and men share many similar oral signs of HIV infection, say researchers at the University of California at San Francisco (UCSF). In a study conducted at the Oral AIDS Center at UCSF,...

Oral lesions in HIV-infected children signal need for more aggressive treatment. (University of California, San Francisco)
March 16, 1992... University of California, San Francisco The presence of oral lesions in HIV-infected children may offer important clues about survival and signals the need for more aggressive treatment of the HIV infection, say clinicians who studied a...

Dentists taking great precautions to insure patient safety. (reducing potential for transmission of bloodborne diseases by checking sterilization equipment) (Washington State)
March 16, 1992... Washington State Snohomish County dentists are taking greater precautions to insure patient safety and reduce any potential for transference of Hepatitis, HIV and other bloodborne diseases between patients and from dentist to patient....

Researchers find sterilized women not guarding against AIDS. (U.S. Centers for Disease Control)
March 16, 1992... U.S. CDC A study of women already at high risk of AIDS from drug abuse finds that those who have been sterilized take fewer precautions against the disease than their counterparts who still worry about pregnancy (see also Department...

Study documents dramatic rise in inner city AIDS. (Maryland)
March 16, 1992... Maryland As the AIDS epidemic in the United States enters its second decade, the disease is afflicting a significantly larger number of inner-city women, teenagers and blacks than it did during the first decade, according to a study of...

Guideline calls for "aggressive pain management." (Agency for Health Care Policy and Research)
March 16, 1992... Agency for Health Care Policy and Research In the first of a new series of federally-sponsored medical care guidelines, a panel of healthcare experts recommended that patients undergoing surgery should receive more active management of...

David Geffen donates $1 million to AIDS Project. (Los Angeles, California)
March 16, 1992... Los Angeles, California AIDS Project Los Angeles (APLA) announced the largest individual donation ever made to an AIDS service organization, a $1 million contribution from entrepreneur David Geffen. The funds will be used to establish...

TLC G-65 expanded Phase II trial of AIDS patients with MAI begun. (Mycobacterium avium-intracellulare) (Liposome Co.)
March 16, 1992... Liposome Co. The Liposome Co., Princeton, New Jersey, announced that it has initiated an expanded Phase II trial with TLC G-65 for the treatment of Mycobacterium avium-intracellulare (MAI) in AIDS patients. The first study site, a...

Rifabutin IND approved. (Investigational New Drug application for Mycobutin) (Adria Laboratories)
March 16, 1992... Adria Laboratories Adria Laboratories announced that the U.S. Food and Drug Administration (FDA) has approved a Treatment IND for rifabutin (Mycobutin). Clinical trials have been conducted with rifabutin for prevention of...

Active recombinant HIV-1 RNase H domain: cloning, expression, purification and characterization. (Research Report)
March 16, 1992... AUTHORS: D.B. Evans, K. Brawn, M.R. Deibel Jr., W.G. Tarpley and S.K. Sharma. The Upjohn Company Upjohn Laboratories, Kalamazoo Michigan. According to an abstract submitted by the authors to the joint meeting of the American Society...