AIDS Weekly articles from June 1995

AIDS Weekly archives from June 1995

Designer drug strategy developed to stop HIV.
June 12, 1995... University of California San Francisco (UCSF) researchers have developed a "designer drug" strategy in which the normal activities of HIV are directed against the virus itself. The approach stops HIV from infecting new cells growing in...

Vitamin E supplementation may slow HIV progression.
June 12, 1995... Vitamin E deficiency may play a contributory role in IgE antibody elevation during the early stages of HIV disease, suggesting that supplementation with the vitamin could potentially slow disease progression. Elevation of IgE has been...

AIDS 'dream team' assembling.(development of new institute for virus research)
June 12, 1995... Lured in part by $12 million in incentives, AIDS scientist Dr. Robert C. Gallo plans to establish a virus research center in Baltimore, Maryland, which is trying to make the biotech industry the foundation of its economic future. Gallo, a...

TB PTS who leave hospitals against medical advise a threat.(tuberculosis patients)
June 12, 1995... Patients with tuberculosis (TB) and AIDS who leave the hospital against medical advice pose a potential risk to the public, and new strategies are needed to keep these patients hospitalized, according to a report from the New York City Department...

Particle-mediated DNA delivery to skin has many advantages.(stimulates immune response in virus patients)
June 12, 1995... Particle-based gene transfer can effectively induce de novo production of foreign antigens in the skin of laboratory animals. The antigen production occurs after submicrogram quantities of an expression plasmid have been delivered...

EBV DNA in CSF may indicate AIDS-related lymphoma.(Epstein-Barr virus, cerebrospinal fluid)
June 12, 1995... Epstein-Barr virus (EBV) DNA detection in cerebrospinal fluid may be useful in the diagnosis of AIDS-related central nervous system lymphoma. Researchers at the Washington University School of Medicine evaluated the diagnostic utility of EBV...

Move from rural to urban area an HIV risk factor in Uganda.
June 12, 1995... Change of residence was strongly associated with an increased risk of HIV-1 infection in a rural Ugandan population, with those moving to more urban areas apparently adopting riskier sexual practices. These findings have important implications...

Is HIV motivated via GP120 immunoglobulin-like domain?
June 12, 1995... A theory regarding the mechanism by which HIV induces immunological abnormalities proposed by Yugoslavian researcher may have implications in the production of an AIDS vaccine. The mechanism associated with the activation of the immune system...

Costs high for failure to get treatment for PCP.(pneumocystis carinii pneumonia)
June 12, 1995... The failure of many people infected with HIV-1 to get preventive treatment for an AIDS-related pneumonia is needlessly costing lives and increasing medical costs, according to a study at the Johns Hopkins Medical Institutions, Baltimore,...

Active CTL selection could contribute to AIDS progression.(cytotoxic T lymphocyte)
June 12, 1995... Active cytotoxic T lymphocyte (CTL) selection of viral variants could contribute to the pathogenesis of AIDS and clinical progression can occur despite high levels of circulating HIV-1-specific CTLs, according to a multicenter report. A high...

Response to flu vaccine poor in HIV+ children.
June 12, 1995... Asymptomatic HIV-infected children responded well to Haemophilus influenza type b conjugate vaccine in a University of Maryland study. The study found, however, that response to the vaccines was poor in rapidly symptomatic HIV-infected infants...

Western blot useful in HIV testing at 18 months or older.
June 12, 1995... Western blot testing should be used for confirmation of HIV infection in babies only after they are 18 months old or older, according to a report from the University of Puerto Rico. While infants born to mothers infected with HIV are nearly...

Large trial of vaccine efficacy in HIV+ needed.
June 12, 1995... A large clinical trial is needed to determine once and for all whether pneumococcal vaccine is effective in HIV-infected patients, according to a report from the United Kingdom. The debate over vaccinating HIV-infected persons against...

Daily treatment to prevent PCP in HIV+ not needed.(Pneumocystis carinii pneumonia)
June 12, 1995... Thrice-weekly trimethoprim-sulfamethoxazole is an effective and well-tolerated regimen for the simultaneous primary prophylaxis of Pneumocystis carinii pneumonia (PCP) and toxoplasmosis in patients infected with HIV, according to a report from...

False-positive TB skin tests at pediatric clinic seen.(tuberculosis)
June 12, 1995... A rash of tuberculin skin test conversions at a Texas pediatric clinic turned out to be false-positives due to a bad batch of purified protein derivative (PPD) solution. "We recommend that healthcare providers remain vigilant regarding...

Anemic children with malaria face HIV risk from treatments.(with blood transfusions)
June 12, 1995... As HIV has emerged as a risk in blood transfusions, their use in the treatment of anemic children with malaria is a grave concern, according to a recent study in Acta Tropica (Mar. 1995: 55-64). Researchers Z. Premji, Y. Hamisi, C. Shiff and...

Thalidomide approved as treatment for AIDS-associated ulcers.
June 12, 1995... Andrulis Pharmaceuticals Corporation, Beltsville, Maryland, announced that it has received notification from the U.S. Food and Drug Administration (FDA) that Andrulis' thalidomide has been designated an orphan drug for the prevention and...

Pleural effusions in HIV positive patients: a review of 231 cases.(reprinted from submission to 1995 International Conference of the American Thoracic Society, May 20-24)(Research Report)(Abstract)
June 12, 1995... According to an abstract submitted by the authors to the 1995 International Conference of the American Thoracic Society, held May 20-24, 1995, in Seattle, Washington, "Because there are no large studies done analyzing the etiology of pleural...

Influence of Tuberculosis on HIV replication.(reprinted from submission to 1995 International Conference of the American Thoracic Society, May 20-24)(Research Report)(Abstract)
June 12, 1995... According to an abstract submitted by the authors to the 1995 International Conference of the American Thoracic Society, held May 20-24, 1995, in Seattle, Washington, "The role of HIV in the emergence of tuberculosis (TB) is now clearly...

PPD response and HIV viral burden among HIV infected injecting drug users without active TB.(tuberculin which is purified protein derivative, tuberculosis)(reprinted from submission to 1995 International Conference of the American Thoracic Society, May 20-24)(Research Report)(Abstract)
June 12, 1995... According to an abstract submitted by the authors to the 1995 International Conference of the American Thoracic Society, held May 20-24, 1995, in Seattle, Washington, "To better understand the impact of tuberculous (TB) infection on the...

Pulmonary manifestations of AIDS related lymphoma.(reprinted from submission to 1995 International Conference of the American Thoracic Society, May 20-24)(Research Report)(Abstract)
June 12, 1995... According to an abstract submitted by the authors to the 1995 International Conference of the American Thoracic Society, held May 20-24, 1995, in Seattle, Washington, "Approximately 5% of patients with AIDS develop lymphomas, with a high...

Striking synergy in HIV replication with tuberculosis co-infection.(reprinted from submission to 1995 International Conference of the American Thoracic Society, May 20-24)(Research Report)(Abstract)
June 12, 1995... According to an abstract submitted by the authors to the 1995 International Conference of the American Thoracic Society, held May 20-24, 1995, in Seattle, Washington, "We have previously demonstrated that HIV infection in alveolar macrophages is...

The changing spectrum of pulmonary disorders in the acquired immunodeficiency syndrome: a post mortem study.(reprinted from submission to 1995 International Conference of the American Thoracic Society, May 20-24)(Research Report)(Abstract)
June 12, 1995... According to an abstract submitted by the authors to the 1995 International Conference of the American Thoracic Society, held May 20-24, 1995, in Seattle, Washington, "The clinical course of patients with acquired immunodeficiency syndrome (AIDS)...

Cloning and biological characterization of human single chain Fv fragments that mediate neutralization of HIV-1 in vitro.(reprinted from submission to 4th International Conference on Human Antibodies and Hybridomas, April 26-28, 1995)(Research Report)(Abstract)
June 12, 1995... According to an abstract submitted by the authors to the 4th International Conference on Human Antibodies and Hybridomas, held April 26-28, 1995, in Amsterdam, The Netherlands, "HIV-1 is the etiological agent of the acquired immune deficiency...

Neutralizing antibodies against HIV-1 from combinatorial phage display libraries.(reprinted from submission to 4th International Conference on Human Antibodies and Hybridomas, April 26-28, 1995)(Research Report)(Abstract)
June 12, 1995... According to an abstract submitted by the authors to the 4th International Conference on Human Antibodies and Hybridomas, held April 26-28, 1995, in Amsterdam, The Netherlands, "Combinatorial phage display libraries were prepared from long-term...

Isolation of scFv-s reactive against HIV-1 antigens from a random-combinatorial human library.(reprinted from submission to 4th International Conference on Human Antibodies and Hybridomas, April 26-28, 1995)(Research Report)(Abstract)
June 12, 1995... According to an abstract submitted by the authors to the 4th International Conference on Human Antibodies and Hybridomas, held April 26-28, 1995, in Amsterdam, The Netherlands, "A phage display library containing 5x10(7) clones was constructed...

The impact of knowledge of human immunodeficiency virus serostatus on contraceptive choice and repeat pregnancy.(reprinted from Obstetrics and Gynecology, May 1995)(Periodical Report)(Abstract)
June 12, 1995... According to the authors' abstract of an article published in Obstetrics and Gynecology, "OBJECTIVE: To examine relationships among human immunodeficiency virus (HIV) serostatus, postpartum contraceptive choice, and the rate of repeat pregnancy...

Anti-HIV and anti-HCMV activities of new aurintricarboxylic acid analogues.(human cytomegalovirus)(reprinted from Antiviral Chemistry & Chemotherapy, May 1995)(Periodical Report)(Abstract)
June 12, 1995... According to the authors' abstract of an article published in Antiviral Chemistry & Chemotherapy, "A variety of aurintricarboxylic acid (ATA) polymer analogues were prepared by substituting certain salicylic acid derivatives and carbonyl...

Clinical, immunologic, and virologic observations related to human immunodeficiency virus (HIV) type I infection in a volunteer in an HIV-1 vaccine clinical trial.(reprinted from Journal of Infections Diseases, May 1995)(Periodical Report)(Abstract)
June 12, 1995... According to the authors' abstract of an article published in Journal of Infectious Diseases, "A vaccine breakthrough occurred in a phase 1 clinical trial of a human immunodeficiency virus (HIV) type 1 candidate subunit vaccine. The vaccine...

Pre- and postexposure protection against human immunodeficiency virus type 1 infection mediated by a monoclonal antibody.(reprinted from Journal of Infections Diseases, May 1995)(Periodical Report)(Abstract)
June 12, 1995... According to the authors' abstract of an article published in Journal of Infectious Diseases, "Monoclonal antibody BAT123 was passively transferred into SCID mice reconstituted with human peripheral blood lymphocytes (hu-PBL-SCID) to study...

Detection of herpesvirus-like DNA sequences in Kaposi's sarcoma in patients with and those without HIV infection.(reprinted from New England Journal of Medicine, May 4, 1995)(Periodical Report)(Abstract)
June 12, 1995... According to the authors' abstract of an article published in New England Journal of Medicine, "BACKGROUND: Herpesvirus-like DNA sequences have recently been found in lesions from patients with Kaposi's sarcoma and the acquired immunodeficiency...

Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas.(reprinted from New England Journal of Medicine, May 4, 1995)(Periodical Report)(Abstract)
June 12, 1995... According to the authors' abstract of an article published in New England Journal of Medicine, "BACKGROUND: DNA fragments that appeared to belong to an unidentified human herpesvirus were recently found in more than 90 percent of Kaposi's...

Evaluation of safety and efficacy of 3TC (Lamivudine) in patients with asymptomatic or mildly symptomatic human immunodeficiency virus infection: a phase I/II study.(reprinted from Journal of Infectious Diseases, May 1995)(Periodical Report)(Abstract)
June 12, 1995... According to the authors' abstract of an article published in Journal of Infectious Diseases, "In a phase I/II study, 7 levels of 3TC therapy (from 0.5 to 20.0 mg/kg/day) were studied in 104 asymptomatic and mildly symptomatic human...

Human immunodeficiency virus type 1 (HIV-1) viremia changes and development of drug-related mutations in patients with symptomatic HIV-1 infection receiving alternating or simultaneous zidovudine and didanosine therapy.(reprinted from Journal of Infectious Diseases, May 1995)(Periodical Report)(Abstract)
June 12, 1995... According to the authors' abstract of an article published in Journal of Infectious Diseases, "The changes in viremia levels and the development of drug-related mutations were examined in 26 patients with symptomatic human immunodeficiency virus...

Comtoxins: theoretical drugs to cure AIDS, cancer, and more.
June 19, 1995... A new, theoretically feasible class of drugs could cure cancer and cell-associated viral or parasitic diseases - including AIDS - and perhaps one day even rejuvenate aging cells. None of these drugs yet exist but some could be created using...

CMV significant risk factor for MAC in HIV. (cytomegalovirus, Mycobacterium avium complex)
June 19, 1995... A diagnosis of cytomegalovirus is an important risk factor for Mycobacterium avium complex (MAC) disease in people with AIDS, and MAC is also a risk factor for subsequent cytomegalovirus disease, according to a report from Baltimore's John's...

Court upholds settlement for HIV tainted blood.
June 19, 1995... A blood bank trade group is partly to blame in the case of a Fair Lawn, New Jersey, man who contracted HIV from a contaminated blood transfusion during a heart bypass operation in 1984, a state appeals court says. The court said the...

CMV can infect broad spectrum of cells during acute infection. (cytomegalovirus)
June 19, 1995... Fibroblasts form a major target cell population of human cytomegalovirus (HCMV) in vivo, in contrast to what has been commonly believed, German researchers indicated. Endothelial cells, epithelial cells and smooth muscle cells also were...

Hyper-IgE linked to clinical signs of HIV infection. (hyperimmunoglobulinemia E)
June 19, 1995... Hyperimmunoglobulinemia E-like syndrome represents a distinct aspect of the clinical manifestations associated with HIV infection, according to a report from Italy. Researcher Roberto Paganelli and colleagues found that the immunologic...

Weight loss in HIV predictive of clinical outcome.
June 19, 1995... Weight loss in patients with HIV infection is independently prognostic of clinical outcome, and development of hypocholesterolemia also indicates negative clinical outcome. Reduced nutrient intake, malabsorption, systemic effects of...

Derivatives of Uniroyal Jr. active against mutant HIV-1.
June 19, 1995... Derivatives of the experimental anti-HIV-1 drug oxathiin carboxanilide (UC84) are highly active against mutant strains of HIV-1 resistant to the parent compound and to other anti-HIV drugs. Better known by its nickname, Uniroyal Jr., UC84 is an...

Metals explored as possible anti-HIV drugs. (metallic compounds)
June 19, 1995... Two bismuth compounds inhibit HIV in vitro, a British/Swiss research team has found. HIV protein chemistry suggests that metal compounds should inhibit the virus. Several HIV proteins contain regions rich in the amino acid cysteine, which can...

Ancient African origin for HTLV-II
June 19, 1995... New genetic evidence suggests that the human T-cell lymphotropic virus type II (HTLV-II) retrovirus is not a New World virus, as is generally thought, but instead originated in Africa. The primate T-lymphotropic retroviruses are related to HIV...

BCG strains expressing nef possible vaccine vector. (Bacilli-Calmette Guerin)
June 19, 1995... It may be possible to construct Bacilli-Calmette Guerin (BCG) vaccine strains expressing nef for eliciting cytotoxic responses for HIV-1 according to a report from France's Institut Pasteur. Different approaches are being undertaken for the...

Viral variability can be overcome.
June 19, 1995... The demonstration of cross-protection between HIV-1 and HIV-2 in rhesus macaques suggests that viral variability may not be an insurmountable problem in the design of a global AIDS vaccine. One of the main problems hindering the development of...

Hepatitis D virus may crowd out hepatitis C.
June 19, 1995... Researchers have found that one type of hepatitis virus may actually help lower the amount of another in hemophiliacs who are infected with HIV. The findings may have implications for improving treatments for hemophiliacs who are infected with...

IGF-1 may be useful in treatment of HIV. (insulin-like growth factor-1)
June 19, 1995... Insulin-like growth factor-1 (IGF-1) has significant inhibitory effects on HIV-1 replication in certain conditions, suggesting that it could be of therapeutic value in AIDS. IGF-1 and insulin are closely related peptides, generally considered...

Saquinavir easily tolerated in AIDS treatment trial.
June 19, 1995... The proteinase inhibitor saquinavir was well tolerated in a group of immunosuppressed HIV-positive men enrolled in a double-blind, dose-ranging study. The HIV proteinase enzyme is a potential target for antiretroviral therapy because its...

CD4-IGG(2) may block cell-to-cell transmission of HIV. (CD4 lymphocytes, immunoglobulin G)
June 19, 1995... The fusion protein CD4-IgG[2] may block cell-to-cell transmission of HIV-1, suggesting that further study of its value as an immunoprophylactic agent for HIV is warranted. An immunoprophylactic agent for HIV-1 exposure would be administered to...

AIDS related non-Hodgkin's lymphoma presenting as a delayed healing of extraction wound: case report.(Research Report)
June 19, 1995... According to an abstract submitted by the authors to the Eighth Mediterranean Symposium on HIV Infection, held March 10-11, 1995, in Toulon, France, "Non-Hodgkin's lymphoma (NHL) is a malignant neoplasm of lymphoid tissue included in the AIDS...

Improved detection of unknown HIV subtypes by the novel fully automated cobras core sandwich screening assay for the detection of anti-HIV antibodies.(Research Report)
June 19, 1995... According to an abstract submitted by the authors to the 7th European Congress of Clinical Microbiology and Infectious Diseases, held March 26-30, 1995, in Vienna, Austria, "The quality of HIV screening assays depends on the earliest possible...

New developments in HIV-diagnostics including HIV-O.(Research Report)
June 19, 1995... According to an abstract submitted by the author to the 7th European Congress of Clinical Microbiology and Infectious Diseases, held March 26-30, 1995, in Vienna, Austria, "The human immunodeficiency virus seems to be older than the currently...

Leishmania on Kaposi's sarcoma lesions.(Research Report)
June 19, 1995... According to an abstract submitted by the authors to the Eighth Mediterranean Symposium on HIV Infection, held March 10-11, 1995, in Toulon, France, "A 29-year-old homosexual male consulted because of fever, diarrhea and general malaise. HIV...

Human monoclonal antibodies against a conformational domain of cytomegalovirus glycoprotein B.(Research Report)
June 19, 1995... According to an abstract submitted by the authors to the 4th International Conference on Human Antibodies and Hybridomas, held April 26-28, 1995, in Amsterdam, The Netherlands, "Human cytomegalovirus (CMV) causes significant morbidity and...

Potency of various human monoclonal antibodies in neutralization of HIV-1 primary isolates and lab strains.(Research Report)
June 19, 1995... According to an abstract submitted by the authors to the 4th International Conference on Human Antibodies and Hybridomas, held April 26-28, 1995, in Amsterdam, The Netherlands, "The envelope protein of HIV-1 is known to possess at least five...

Rapid genotyping of hepatitis C virus by restriction fragment length polymorphisms of PCR product without radioisotope incorporation.(Research Report)
June 19, 1995... According to an abstract submitted by the authors to the 7th European Congress of Clinical Microbiology and Infectious Diseases, held March 26-30, 1995, in Vienna, Austria, "Hepatitis C virus (HCV) is a major cause of parenterally transmitted...

Susceptibility testing of mycobacterium tuberculosis and mycobacterium avium intracellulare using the Etest.(Research Report)
June 19, 1995... According to an abstract submitted by the authors to the 7th European Congress of Clinical Microbiology and Infectious Diseases, held March 26-30, 1995, in Vienna, Austria, "The incidence of disease due to mycobacterium, particularly M....

Adriamycin, bleomycin and vinblastine (ABV) chemotherapy with recombinant granulocyte colony-stimulating factor (rG-CSF) in the treatment of AIDS-related Kaposi's Sarcoma.(Research Report)
June 19, 1995... According to an abstract submitted by the authors to the Eighth Mediterranean Symposium on HIV Infection, held March 10-11, 1995, in Toulon, France, "OBJECTIVE: To evaluate the efficacy and toxicity of a therapeutic scheme with ABV in...

Analysis of apoptosis in lymph nodes of HIV-infected persons - intensify of apoptosis correlates with the general state of activation of the lymphoid tissue and not with stage of disease or viral burden.(reprinted from Journal of Immunology, May 15, 1995)(Periodical Report)(Abstract)
June 19, 1995... According to the authors' abstract of an article published in Journal of Immunology, "The occurrence of in vivo apoptosis was investigated in lymph node sections obtained from HIV-infected persons at different stages of disease. The degree of...

Pulmonary manifestations in HIV patients: the role of chest films, CT and HRCT.(Reprinted from Fortschritte auf dem Gebiete der Rontgenstrahlen und der Neuen Bildgebenden Verfahren, April 1995)(Periodical Report)(Abstract)
June 19, 1995... According to the authors' abstract of an article published in Fortschritte auf dem Gebiete der Rontgenstrahlen und der Neuen Bildgebenden Verfahren, "AIM: To determine the prevalence of pulmonary changes on chest radiographs and computed...

Increased cellular uptake of the human immunodeficiency virus-1 Tat protein after modification with biotin.(reprinted from Analytical Biochemistry, May 1, 1995)(Periodical Report)(Abstract)
June 19, 1995... According to the authors' abstract of an article published in Analytical Biochemistry, "The human immunodeficiency virus-1 Tat protein can efficiently enter cells when added exogenously in tissue culture. Using the transactivation activity of...

Antitat gene therapy: a candidate for late-stage AIDS patients.(reprinted from Gene Therapy, May 1995)(Periodical Report)(Abstract)
June 19, 1995... According to the authors' abstract of an article published in Gene Therapy, "Antitat is an autoregulated gene expressing an inhibitory RNA with dual function: if sequesters the Tat protein by polymeric-TAR and blocks the translation of the Tar...

Continuous secretion of human soluble CD4 in mice transplanted with genetically modified cells. (CD4 lymphocytes)(reprinted from Gene Therapy, May 1995)(Periodical Report)(Abstract)
June 19, 1995... According to the authors' abstract of an article published in Gene Therapy, "Somatic transgenesis can be used to confer endogenous production of proteins with therapeutic properties. One such product, recombinant soluble human CD4 (sCD4), has...

Incentives and disincentives to participate in prophylactic HIV vaccine research.(reprinted from Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, May 1, 1995)(Periodical Report)(Abstract)
June 19, 1995... According to the authors' abstract of an article published in Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, "An anonymous cross-sectional paper-and-pencil survey was used to assess incentives and disincentives to...

Utility of various commercially available human immunodeficiency virus (HIV) antibody diagnostic kits for use in conjunction with efficacy trials of HIV-1 vaccines.(reprinted from Clinical and Diagnostic Laboratory Immunology, May 1995)(Periodical Report)(Abstract)
June 19, 1995... According to the authors' abstract of an article published in Clinical and Diagnostic Laboratory Immunology, "There is a need for human immunodeficiency virus (HIV) screening assays which will distinguish uninfected HIV vaccine recipients from...

Mycobacterium tuberculosis enhances human immunodeficiency virus-1 replication by transcriptional activation at the long terminal repeat.(reprinted from Journal of Clinical Investigation, May 1995)(Periodical Report)(Abstract)
June 19, 1995... According to the authors' abstract of an article published in Journal of Clinical Investigation, "Tuberculosis has emerged as an epidemic fueled by the large number of individuals infected with the human immunodeficiency virus, especially those...

Mortality among HIV-infected intravenous drug addicts in Stockholm in relation to methadone treatment.(reprinted from Addiction, May 1995)(Periodical Report)(Abstract)
June 19, 1995... According to the authors' abstract of an article published in AIDS, "OBJECTIVE: To study the association between change of residence and HIV-1 serostatus in a rural Ugandan population. DESIGN: A longitudinal cohort study. METHODS: As part of...

Migration and HIV-1 seroprevalence in a rural Ugandan population.(reprinted from AIDS, May 1995)(Periodical Report)(Abstract)
June 19, 1995... According to the authors' abstract of an article published in AIDS, "OBJECTIVE: To study the association between change of residence and HIV-1 serostatus in a rural Ugandan population. DESIGN: A longitudinal cohort study. METHODS: As part of...

New drug targets host response to HIV.(CT-2576)
June 26, 1995... A new drug inhibits HIV production by preventing host cells from responding to HIV signals. The drug is 1-(11-octylamino-10-hydroxyundecyl)-3,7- dimethylxanthine, or commonly known as CT-2576. CT-2576 inhibits HIV expression in U1 cells at a...

AZT-resistant HIV causes perinatal transmission.
June 26, 1995... A Washington state study adds to the evidence that maternal treatment with oral zidovudine reduces the rate of HIV-1 transmission to the baby, but indicates that vertical transmission of virus resistant to zidovudine can occur. Infection of...

Adrenal insufficiency after megace withdrawal.
June 26, 1995... An AIDS patient who had taken megestrol acetate (Megace, Bristol-Myers, Princeton, New Jersey) for four years developed adrenal insufficiency after discontinuing the drug. A subsequent prospective study of Megace in four other AIDS patients...

LOS antigen detects TB in both HIV+ and HIV-.(lipooligosaccharide)
June 26, 1995... Lipooligosaccharide (LOS) antigen is a potential marker for detecting the development of tuberculosis in HIV-infected patients, according to a report from France. In this study researcher G. Daleine and colleagues assessed the value of...

Synthetic peptide bars door to HIV entry.
June 26, 1995... A new synthetic peptide has at least two mechanisms of action that prevent HIV from entering CD4(+) and CD4(-) cells. The peptide, SPC3, is a type of multibranched polymer - dubbed synthetic polymeric constructions or SPCs - originally...

U.S. Supreme Court reviewing AZT patent challenge.
June 26, 1995... Barr Laboratories, Inc., Pomona, New York, said that it is pleased with what the company believes is a positive development in its challenge of the Burroughs Wellcome Co.'s patents on zidovudine (AZT). In March 1995, Barr filed a petition...

PN355 and AZT combination promoted. (new antiviral agent)
June 26, 1995... Laboratory studies suggest that Paracelsian's, Ithaca, New York, antiviral agent, PN355, can boost the effectiveness of AZT (zidovudine, Retrovir by Glaxo Wellcome), according to a statement by John Babish, Ph.D., chief scientist at Paracelsian....

HIV transmission in dialysis center is reported.
June 26, 1995... An outbreak of HIV transmission was discovered by accident and confirmed at a dialysis center in Columbia, South America. The transmission probably occurred through improperly reprocessed patient care equipment, and most probably through access...

Hepatitis A vaccine useful in HIV+, but less immunogenic.
June 26, 1995... A German study adds to the evidence that hepatitis A vaccine is safe and well tolerated in HIV-positive homosexual males, but is less immunogenic than in the general population. The increased prevalence of antibodies to hepatitis A virus (HAV)...

Prior HIV-2 infection reduces chance of acquiring HIV-1.
June 26, 1995... The discovery that bodies infected by a weak form of HIV learn to protect themselves against AIDS could lead towards finding a vaccine against the disease, researchers say. Dr. Phyllis Kanki, a scientist at the Harvard School of Public Health,...

M. Xenopi looks like TB in HIV+.(Mycobacterium xenopi)
June 26, 1995... HIV-infected patients may have pulmonary Mycobacterium xenopi infection that is clinically indistinguishable from tuberculosis. Researcher Helen M. Jacoby and colleagues at New York's University of Rochester Medical Center report two such cases...

Diarrhea not always seen in HIV related microsporidiosis.
June 26, 1995... Diarrhea and severe villus injury do not invariably accompany infection with microsporidiosis in HIV positive persons. In half of all AIDS cases accompanied by diarrhea, the enteric pathogen is not identified. "The main hypothesis proposed...

Early therapy crucial in AIDS patients with acanthamoeba.
June 26, 1995... Early therapy in AIDS patients with acanthamoeba can mean the difference between life and death, and clinical and laboratory personnel must keep a high degree of suspicion for this infection. Acanthamoeba species are known to cause two...

Positive coccidioidal tests predictive of disease.(in HIV patients)
June 26, 1995... Persistently positive coccidioidal serological tests in HIV infected patients may represent true coccidioidal infection and are associated with a significant risk of the development of active coccidioidomycosis. Coccidioidomycosis is a fungal...

Pulmonary MAC disease is often an AIDS defining condition.(Mycobacterium avium complex)
June 26, 1995... Mycobacterium avium complex (MAC) disease often presents as an AIDS defining infection rather than later in the course of the disease, according to a report from Ohio's Case Western Reserve University. MAC is a common complication in patients...

SIV study suggests AIDS vaccine feasible.(simian immunodeficiency virus)
June 26, 1995... An AIDS vaccine study found that macaques were protected by attenuated simian immunodeficiency virus (SIV) against challenge with virus-infected cells. The study, reported by N. Almond et al. of the United Kingdom's National Institute for...