AIDS Weekly articles from January 1994

AIDS Weekly archives from January 1994

Abbott announces first treatment for AIDS-related infection. (Abbott Laboratories; Biaxin for Mycobacterium avium complex) (Illinois)
January 10, 1994... Abbott Laboratories, Abbott Park, Illinois, announced a new indication for Biaxin (clarithromycin), its macrolide antibiotic, for the treatment of disseminated Mycobacterium avium complex (MAC). Biaxin is the first drug to receive an...

Preventive treatment for pneumonia extends AIDS-free time. (Pneumocystis carinii pneumonia) (Johns Hopkins)
January 10, 1994... HIV-positive men may gain an extra six to 12 months of time before the start of their first AIDS disease if they get preventive treatment for Pneumocystis carinii pneumonia (PCP). That finding comes in a study by researchers at the Johns...

Anti-idiotypic antibodies show promise as AIDS vaccine. (Wistar Institute)
January 10, 1994... Anti-idiotypic antibodies (anti-ids) developed at the Wistar Institute, Philadelphia, Pennsylvania, show promise as an AIDS vaccine, the Institute said. Often, the immune system mounts a weak response to HIV. Anti-ids recently...

IND filed for Phase III trial of Immupath. (investigational new drug application; plasma-derived biopharmaceutical for passive hyperimmune therapy) (U.S. Food and Drug Administration)
January 10, 1994... HemaCare Corporation, Los Angeles, California, on January 3, 1994, announced the filing with the U.S. Food and Drug Administration (FDA) of an Investigational New Drug (IND) application to begin U.S. Phase III clinical trials of Immupath, a...

Expanded IND for AIDS immune reconstitution cell-transfer therapy submitted. (investigational new drug application) (U.S. Food and Drug Administration)
January 10, 1994... Health Professionals Inc., Fort Lauderdale, Florida, announced that its wholly owned subsidiary, Center for Special Immunology (CSI), has submitted an Investigational New Drug Application (IND) with the U.S. Food and Drug Administration (FDA)...

Medical center's developers of novel AIDS vaccine win $2.2 million grant. (Duke University)
January 10, 1994... Duke University Medical Center, Durham, North Carolina, scientists who have mixed protein pieces from different strains of HIV into a unique "cocktail" vaccine for AIDS have been awarded a $2.2 million grant to develop it further. The...

Alternating AZT and ddC promotes drug resistance. (zidovudine, zalcitabine) (New Jersey)
January 10, 1994... Alternating AIDS therapy with AZT and ddC appears to result in the selection of viruses resistant to both drugs, according to a report from New Jersey's Robert Wood Johnson Medical School. Researcher J.E. Fitzgibbon and colleagues...

Agouron and Lilly exchange anti-viral technology. (Agouron Pharmaceuticals Inc., Eli Lilly and Co.) (California)
January 10, 1994... Agouron Pharmaceuticals Inc., La Jolla, California, announced that it has agreed to provide Eli Lilly with proprietary details of the three-dimensional atomic structure of a new anti-viral drug target recently solved by Agouron scientists....

Novel protease inhibitors to treat HIV infection and AIDS. (North Carolina)
January 10, 1994... Wellcome plc signed a collaborative agreement with Vertex Pharmaceuticals Inc., Cambridge, Massachusetts, which is intended to accelerate the development of some promising protease inhibitors as potential treatments for HIV infection and...

Dun & Bradstreet subsidiary to monitor HIV/AIDS. (Dun & Bradstreet HealthCare Information) (U.S. Centers for Disease Control and Prevention)
January 10, 1994... Dun & Bradstreet HealthCare Information, a division of the Dun & Bradstreet Corporation, announced that it has been awarded a cooperative agreement by the U.S. Centers for Disease Control and Prevention (CDC) to conduct a study designed to...

"Womansource HIV" to address unique needs of women with HIV. (educational video series) (North Carolina)
January 10, 1994... In response to the consistent increase of HIV disease among women, Burroughs Wellcome Company, Research Triangle Park, North Carolina, has created Womansource HIV, an educational video series developed for HIV -infected women and their...

University receives unique AIDS grant. (for gene therapy research) (University of Colorado)
January 10, 1994... The Division of Infectious Diseases at the University of Colorado (CU) Health Sciences Center has been awarded a three-year, $1.3 million, U.S. National Institutes of Health grant to begin unique research in the feasibility of using gene...

Clindamycin use and prolonged hospitalization are risk factors associated with Clostridium difficile-associated diarrhea in HIV-infected patients. (France)
January 10, 1994... The use of clindamycin and prolonged hospitalization in the ward were main risk factors associated with Clostridium difficile-associated diarrhea (CDAD) in HIV -infected patients, reported French researchers. In addition, the occurrence...

Length of contact time is a main risk factor in transmission of Mycobacterium bovis. (France)
January 10, 1994... Mycobacterium bovis can be transmitted nosocomially, and the length of contact time with an infected patient appears to be a main risk factor for transmission to HIV -infected patients, stated French researchers. Respiratory isolation...

Federally funded condom advertisements break new ground. (U.S. Centers for Disease Control and Prevention)
January 10, 1994... The U.S. Centers for Disease Control and Prevention (CDC) launched its series of new radio and television public service announcements (PSAs) targeting sexually active young people who are at increased risk for HIV infection. The PSAs are...

Judge orders condom ads on Boston buses, subways. (Rya Zobel) (Massachusetts)
January 10, 1994... A federal judge has ordered Boston's mass transit agency to begin carrying controversial condom ads on metropolitan area buses and subways - without any changes. U.S. District Judge Rya Zobel ruled the Massachusetts Bay Transportation...

Television forces changes in condom commercial. (Israel)
January 10, 1994... Israel's new commercial television station broadcast a condom commercial, but changed it to soften some of its sexual suggestiveness, an official said. Before it was changed, the 10-second spot showed a jeans-clad banana sliding in and...

Police to investigate anonymous flier accusing lab of AIDS cover-up. (Linus Pauling Institute) (California)
January 10, 1994... Police confirmed they are investigating the appearance of an anonymous flier accusing a famed scientific research facility of covering up a 1990 incident in which a vial containing HIV was found in the laboratory's parking lot. ...

Distribution agreements for sale of rapid HIV test kits completed. (South America)
January 10, 1994... Disease Detection International Inc. (DDI), Irvine, California, announced the company has finalized contractual documents with Bio-Diagnostica Inc., Miami, Florida, for the exclusive distribution rights in Venezuela, Chile and Argentina of...

Researchers discover ancestor of AIDS virus, other retroviruses. (Ohio)
January 10, 1994... Researchers have found what appears to be the "missing link" connecting the ancient world of viruslike RNAs and other primitive entities to retroviruses and the modern world of DNA-based creatures. The discovery provides new...

HIV carriers jumps five-fold. (Indonesia)
January 10, 1994... Alarmed by a sharp increase in the number of people carrying HIV, the Indonesian government has allocated more than $2 million for programs designed to halt the spread of the disease, the official news agency Antara reported. Health...

Toxicokinetics of didanosine in mice after administration as a diet admixture. (Research Report)
January 10, 1994... AUTHORS: J.A. McDowell, C.A. Knupp, C.R. Gleason, L.D. Hopper and R.H. Barbhaiya. Departments of Toxicology and Metabolism and Pharmacokinetics, Bristol-Myers Squibb Company, Syracuse, New York. According to an abstract presented by the...

The role of hydrophobicity in the clearance of HIV protease inhibitors. (Research Report)
January 10, 1994... AUTHORS: M.J. Ruwart 1, B.D. Rush 1, K.F. Wilkinson 1, C. Rieden 1, T.J. Vidmar 2, J.F. Fisher 3, T.K. Sawyer 4, J.B. Hester 3 and S. Thaisrivongs 3. 1Drug Delivery Systems Research; 2Biostatistics, 3Medicinal Chemistry; and 4Biochemistry, the...

AIDS risk reduction behaviors among participants of syringe exchange programs in New York City, USA. (Research Report)
January 10, 1994... AUTHORS: P. Denise, D.C. Des Jarlais, S. Calour and P. Friedmann. Beth Israel Medical Center, New York, New York. According to an abstract submitted by the authors to the 121st Annual Meeting of the American Public Health Association, held...

High HIV prevalence among female and male entrants to U.S. correctional facilities (1989-1992): implications for prevention and treatment strategies. (Research Report)
January 10, 1994... AUTHORS: D.G. Withum, F. Guerena-Burgueno, M. Gwinn, J.S. Lehman and L.R. Petersen. U.S. Centers for Disease Control and Prevention, Atlanta, Georgia. According to an abstract submitted by the authors to the 121st Annual Meeting of the...

Blood collection and anti-HIV test results during Operation Desert Storm. (Research Report)
January 10, 1994... AUTHORS: B.I. Whitaker 1, S.M. Benavides 1, M.F. Cotton 1 and S.M. Randolph 2. 1American Red Cross, Washington, DC and 2University of Maryland, College Park, Maryland. According to an abstract presented by the authors to the 46th annual...

Conformationally constrained peptide tertiary structural templates (PTST) for AIDS vaccine development: III. (Research Report)
January 10, 1994... AUTHORS: A. Komoriya. Centers for Biologics Evaluation and Research, Federal Drug Administration, Bethesda, Maryland. According to an abstract presented by the authors to the 1st International Conference on Engineered Vaccines for Cancer...

Immune responses of HIV-1 seronegative individuals vaccinated with recombinant HIV-SF2 gp120. (Research Report)
January 10, 1994... AUTHORS: K.S. Steimer 1, F. Sinangil 1, J. Baenziger 1, J. Kahn 2 and D. Chernoff 1. 1the Biocine Company/Chiron, Emeryville, California, 2San Francisco General Hospital, California. According to an abstract presented by the authors to...

Production of immunogens to elicit an anti-HIV mucosal immune response. (Research Report)
January 10, 1994... AUTHORS: J.M. Winchell 1, L.K. Silbart 1, T.J. Palker 2, J.D. Clements 3, P.W. Betts 1 and B.F. Haynes 2. 1University of Connecticut, Storrs, Connecticut; 2Duke University Medical Center, Durham, North Carolina; 3Tulane University Medical...

Primary central nervous system lymphoma. (Periodical Report) (Abstract)
January 10, 1994... SOURCE: Annals of Internal Medicine, December 1, 1993;119(11):1093-1104. According to the authors' abstract of an article published in Annals of Internal Medicine, "Objective: To compare the pathogenesis, clinical presentation, therapy,...

Contraception choice and sexually transmitted disease. (Periodical Report) (Abstract)
January 10, 1994... SOURCE: Current Opinion in Obstetrics & Gynecology, December 1993;5(6):823-828. According to the authors' abstract of an article published in Current Opinion in Obstetrics & Gynecology, "Sexually active couples need to be concerned with...

Sexuality - sexual activity and contraception during adolescence. (Periodical Report) (Abstract)
January 10, 1994... SOURCE: Current Opinion in Obstetrics & Gynecology, December 1993;5(6):774-783. According to the author's abstract of an article published in Current Opinion in Obstetrics & Gynecology, "Adolescent sexual activity is increasing. Premature...

Pneumonia caused by an atypical Mycobacterium in AIDS. (Mycobacterium xenopi) (Periodical Report) (Abstract)
January 10, 1994... SOURCE: Deutsche Medizinische Wochenschrift, November 12, 1993;118(45):1636-1640. According to the authors' abstract of an article published in Deutsche Medizinische Wochenschrift, "A 38 -year-old man, HIV-positive for 6 years, developed...

Depressive symptoms and CD4 lymphocyte decline among HIV-infected men. (Periodical Report) (Abstract)
January 10, 1994... SOURCE: Journal of the American Medical Association, December 1, 1993;270(21):2568-2573. According to the authors' abstract of an article published in the Journal of the American Medical Association, "Objective: To investigate whether...

Depressive symptoms as predictors of medical outcomes in HIV infection. (Periodical Report) (Abstract)
January 10, 1994... SOURCE: Journal of the American Medical Association, December 1, 1993;270(21):2563-2567. According to the authors' abstract of an article published in the Journal of the American Medical Association, "Objective: To ascertain whether...

Establishment of a quality assurance program for human immunodeficiency virus type-1 DNA polymerase chain reaction assays by the AIDS Clinical Trials Group. (Periodical Report) (Abstract)
January 10, 1994... SOURCE: Journal of Clinical Microbiology, December 1993;31(12):3123-3128. According to the authors' abstract of an article published in the Journal of Clinical Microbiology, "An independent quality assurance program has been established by...

Virological diagnosis of progressive multifocal leukoencephalopathy - detection of JC virus DNA in cerebrospinal fluid and brain tissue of AIDS patients. (Periodical Report) (Abstract)
January 10, 1994... SOURCE: Journal of Clinical Microbiology, December 1993;31(12):3310-3313. According to the authors' abstract of an article published in the Journal of Clinical Microbiology, "Cerebrospinal fluid (CSF) from 12 AIDS patients with clinical...

Bristol-Myers Squibb files NDA for anti-AIDS drug Zerit (stavudine, d4T). (New Drug Application) (New York)
January 17, 1994... New York Bristol-Myers Squibb Company, New York, New York, announced that it has submitted a New Drug Application (NDA) to the U.S. Food and Drug Administration (FDA) seeking approval to market Zerit (stavudine, d4T), an experimental...

New treatment for prevention of pneumonia in immunosuppressed patients. (Bactrim, trimethoprim and sulfamethoxazole)
January 17, 1994... U.S. Hoffmann-LaRoche Inc., Nutley, New Jersey, received U.S. Food and Drug Administration (FDA) clearance to market its oral antibacterial drug Bactrim (trimethoprim and sulfamethoxazole) for prophylaxis against Pneumocystis carinii...

Fear hampers AIDS vaccine work. (difficulty recruiting volunteers) (Johns Hopkins School of Medicine)
January 17, 1994... Johns Hopkins School of Medicine The reluctance of women and minorities to volunteer for an AIDS vaccine experiment is hampering research, scientists at the Johns Hopkins School of Medicine, Baltimore, Maryland, said. The main...

CD26 cofactor study precipitates controversy. (France)
January 17, 1994... France A French study purporting to demonstrate that the CD26 surface protein is the long-sought cofactor that helps HIV to infect cells has drawn fire from American researchers. The findings of the research were presented at the...

Intravenous immunoglobulin effective in slowing CD4+ cell declines. (U.S. National Institute of Child Health and Human Development)
January 17, 1994... U.S. NICHHD Treatment with intravenous immunoglobulin (IVIG) resulted in a slowing of CD4+ cell count decline in HIV -infected children with initial CD4+ cell counts of >/=0.20 x 10(9)/L, report researchers from the U.S. National...

AIDS will not significantly reduce population growth. (United Nations)
January 17, 1994... United Nations It is time to dispel the notion that the HIV/AIDS pandemic will significantly reduce or even reverse population growth, according to the United Nations. According to an article in the December 1993 issue of Populi,...

Americans over 50 less likely to take AIDS precautions. (University of California, San Francisco)
January 17, 1994... University of California, San Francisco Older Americans shouldn't be forgotten in efforts to bring AIDS-prevention messages to the public, health experts say. "Every year in this epidemic, 10 percent of the people diagnosed (with...

Doctors not asking about patients' sexual history. (U.S. Centers for Disease Control and Prevention)
January 17, 1994... U.S. CDC Although AIDS has emerged as a major killer of young Americans, many physicians do not ask patients about their sexual histories, missing an opportunity to help prevent the disease, government health officials reported. ...

Endangered vine shows promise as anti-AIDS drug. (Ancistrocladus korupensis is source of michellamine B) (U.S. National Cancer Institute)
January 17, 1994... U.S. NCI A substance extracted from a previously unknown species of vine in West Africa has been found to prevent HIV infection in vitro. The substance, called michellamine B, is extracted from a vine, Ancistrocladus korupensis,...

HEPT-derivatives active against resistant HIV strains. (Belgium)
January 17, 1994... Belgium 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) derivatives retain significant activity against HIV-1 mutant strains that are resistant to other HIV-1 -specific inhibitors, according to a report from a Belgian research...

Azole resistance common in AIDS patients. (North Carolina)
January 17, 1994... North Carolina Azole resistance of oropharyngeal yeasts is a common problem in patients infected with HIV-1, and this resistance has clinical relevance, according to a study from North Carolina's Duke University Medical Center. ...

Cost-effectiveness of HIV prevention strategies studied. (United Kingdom)
January 17, 1994... United Kingdom The examination of the cost-effectiveness of HIV prevention strategies used in the developing world is hampered by the lack of any measure of the effectiveness of the prevention programs themselves, British researchers...

Larger condom needed. (United Kingdom)
January 17, 1994... United Kingdom A larger condom may be needed by some men to reduce the risk of the condom coming off or splitting during intercourse, British researchers report ("Condoms: A Wider Range Needed," British Medical Journal,...

In situ PCR measures levels of HIV-1 in peripheral blood. (polymerase chain reaction) (Pennsylvania)
January 17, 1994... Pennsylvania In certain HIV-infected individuals, high levels of CD4+ lymphocytes may harbor the HIV-1 provirus, according to researchers from Thomas Jefferson University, Philadelphia, Pennsylvania ("High Percentages of CD4 -Positive...

Epidemiology of AIDS may be heterogeneous. (Colorado)
January 17, 1994... Colorado Research published in November 1993 issue of AIDS suggests that the epidemiology of AIDS may be more heterogeneous in nature than has previously been supposed ("AIDS in Colorado Springs: Is There an Epidemic?" AIDS, November...

Progenics Pharmaceuticals awarded NIH grant for development of second-generation AIDS vaccine. (National Institutes of Health) (New York)
January 17, 1994... New York Progenics Pharmaceuticals Inc., Tarrytown, New York, announced that it has been awarded $500,000 under Phase II of a Small Business Innovation Research Program (SBIR) grant by the U.S. National Institute of Allergy and...

Novel RNA process promises new therapies for diseases. (ribozymes) (University of Colorado)
January 17, 1994... University of Colorado A novel biological strategy developed at the University of Colorado (CU) at Boulder now allows scientists to "address" therapeutic RNA molecules with chemical signals and send them on cellular journeys to destroy...

Trinity Biotech announces pre-clinical trial results of SalivaCard and SeroCard HIV-1/2. (diagnostic tests) (Ireland)
January 17, 1994... Ireland Trinity Biotech, Dublin, Ireland, announced that its initial pre-clinical trials with both HIV-1/2 SeroCard and HIV-1/2 SalivaCard have been completed. The results, collated from 10 centers in Italy, Sweden, Mexico,...

Unusual pathogens in HIV-infected patients. (Research Report)
January 17, 1994... AUTHORS: O. Patey, B. Halioua, J.E. Malkin, T. Prazuck, J. Breuil, S. Levy and C. Lafaix. Service des Maladies Infectieuses et tropicales, laboratoire de microbiologie, St. Georges, France. According to an abstract presented by the...

Chronic hypertrophic parotitis in HIV-infected children. (Research Report)
January 17, 1994... AUTHORS: M. Dragan, I. Strauss, M. Luminos, D. Giurgiutiu and A. Hristea. According to an abstract presented by the authors to the 1st Scientific Meeting of the European Society of Chemotherapy Infectious Diseases held November 25-27,...

Long-term inhibition of clinical and laboratory HIV strains conferred by an HIV-regulated diphtheria toxin A-chain gene. (Research Report)
January 17, 1994... AUTHORS: G.S. Harrison 1, D. Nicot 1, Y. Wang 1, B.H. Hahn 2, S.K. Ghosh 2 and T.J. Curiel 1. 1Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado; 2Department of Medicine, University of Alabama,...

Risk factors for bacterial pneumonia among HIV seropositive (HIV+) intravenous drug users (IDUs). (Research Report)
January 17, 1994... AUTHORS: W.T. Caiaffa, D. Vlahov, N.M.H. Graham, L. Solomon, K.E. Nelson, J. Astemborski and A. Munoz. Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, Maryland. According to an abstract submitted by the...

Liposome encapsulated gentamicin (L-GM) in the treatment of disseminated Mycobacterium avium complex (DMAC) disease in AIDS. (Research Report)
January 17, 1994... AUTHORS: M. Pierce and M. Morgan. Vanderbilt University Medical Center, Nashville, Tennessee. According to an abstract submitted by the authors to the 33rd Interscience Conference on Antimicrobial Agents and Chemotherapy, held October...

Prior access to care shortens PCP hospitalizations. (Pneumocystis carinii pneumonia) (Research Report)
January 17, 1994... AUTHORS: S.E. Cohn 1, P. Lyna 2, J.D. Klein 1, B. Peterson 2, W.E. Cunningham 2, M.F. Shapiro 2 and C.L. Bennett 2. 1University of Rochester, Rochester, New York and 2Duke/Rand PCP Study. According to an abstract submitted by the...

Identification of HIV-1+2 CTL epitopes restricted through A2, B8, B35 and B53. (cytotoxic T lymphocytes) (Research Report)
January 17, 1994... AUTHORS: S.N. McAdam 1, F. Gotch 1, S. Rowland-Jones 1, K. Ariyoshi 2, H. Whittle 2 and A. McMichael 1. 1The Institute of Molecular Medicine, Oxford, United Kingdom and 2Medical Research Laboratories, Fajara, The Gambia. According to...

Multiple immune responses induced by recombinant adenovirus. (Research Report)
January 17, 1994... AUTHORS: V. Juillard, D. Godfrin, P. Villefroy, T. Ragot, M. Perricaudet, J.-G. Guillet and A. Venet. Institut Cochin de Genetique Moleculaire, Paris, and Institut Gustave Roussy, Villejuif, France. According to an abstract presented...

Deep scopulariopsosis in the immunocompromised host. (Research Report)
January 17, 1994... AUTHORS: R. Patel, C.A. Gustaferro, R.A. Krom, R.H. Weisner, G.D. Roberts and C.V. Paya. Mayo Clinic, Rochester, Minnesota. According to an abstract presented by the authors to the 31st Annual Meeting of the Infectious Disease Society...

Evaluation of two staging systems for HIV infection for use in developing countries - short communication. (Periodical Report) (Abstract)
January 17, 1994... SOURCE: AIDS, December 1993;7(12):1613-1615. According to the authors' abstract of an article published in AIDS, "Objective: To evaluate the clinical axis of the World Health Organization (WHO) clinical staging system and the...

Impact of HIV counseling and testing among child-bearing women in Kinshasa, Zaire. (Periodical Report) (Abstract)
January 17, 1994... SOURCE: AIDS, December 1993;7(12):1633-1637. According to the authors' abstract of an article published in AIDS, "Objective: To determine the impact of HIV counseling and testing among child-bearing women. Study Setting: Mama Yemo...

Lack of synergy in the inhibition of HIV-1 reverse transcriptase by combinations of the 5'-triphosphates of various anti-HIV nucleoside analogs. (Periodical Report) (Abstract)
January 17, 1994... SOURCE: Antiviral Research, December 1993;22(4):295 -308. According to the authors' abstract of an article published in Antiviral Research, "3'-Deoxy-3' -azidothymidine (AZT) has been shown to synergistically inhibit the replication...

Novel indolocarbazole protein kinase-C inhibitors prevent reactivation of HIV-1 in latently infected cells. (Periodical Report) (Abstract)
January 17, 1994... SOURCE: Antiviral Research, December 1993;22(4):273 -283. According to the authors' abstract of an article published in Antiviral Research, "Suppression of human immunodeficiency virus-1 (HIV-1) reactivation in latently infected...

Cross-reactive response to human immunodeficiency virus type-1 (HIV-1) gp120 and HLA class-I heavy chains induced by receipt of HIV-1-derived envelope vaccines. (Periodical Report) (Abstract)
January 17, 1994... SOURCE: Journal of Infectious Diseases, December 1993;168(6):1396-1403. According to the authors' abstract of an article published in Journal of Infectious Diseases, "Autoantibodies specific to HLA class I antigens were detected in...

Quinolinic acid in the cerebrospinal fluid of children with symptomatic human immunodeficiency virus type-1 disease - relationships to clinical status and therapeutic response. (Periodical Report) (Abstract)
January 17, 1994... SOURCE: Journal of Infectious Diseases, December 1993;168(6):1380-1386. According to the authors' abstract of an article published in Journal of Infectious Diseases, "Quinolinic acid (QUIN) is a neurotoxin implicated in the...

The association between circumcision status and human immunodeficiency virus infection among homosexual men. (Periodical Report) (Abstract)
January 17, 1994... SOURCE: Journal of Infectious Diseases, December 1993;168(6):1404-1408. According to the authors' abstract of an article published in Journal of Infectious Diseases, "To evaluate whether uncircumcised status is correlated with...

Cooperative inhibition of NF-kB and Tat-induced superactivation of human immunodeficiency virus type-1 long terminal repeat. (Periodical Report) (Abstract)
January 17, 1994... SOURCE: Proceedings of the National Academy of Sciences of the United States of America, December 1, 1993;90(23):11044-11048. According to the authors' abstract of an article published in Proceedings of the National Academy of...

Costimulation of T-cell activation and virus production by B7-antigen on activated CD4+ T-cells from human immunodeficiency virus type-1-infected donors. (Periodical Report) (Abstract)
January 17, 1994... SOURCE: Proceedings of the National Academy of Sciences of the United States of America, December 1, 1993;90(23):11094-11098. According to the authors' abstract of an article published in Proceedings of the National Academy of...

Restoration of HIV-specific cell-mediated immune responses by interleukin-12 in vitro. (Periodical Report) (Abstract)
January 17, 1994... SOURCE: Science, December 10, 1993;262(5140):1721-1724. According to the authors' abstract of an article published in Science, "Peripheral blood mononuclear cells (PBMCs) from many asymptomatic individuals infected with human...

Evaluation of HIV testing in Sweden, 1985-1991. (Periodical Report) (Abstract)
January 17, 1994... SOURCE: AIDS, December 1993;7(12):1625-1631. According to the authors' abstract of an article published in AIDS, "Objective: Evaluation of the extent and outcome of HIV testing in Sweden. Design: Data from screening programmes,...

AIDS epidemic cuts cancer survival in younger men. (U.S. National Cancer Institute)
January 24, 1994... DATELINE: U.S. NCI The high prevalence of certain cancers among AIDS patients could lower overall cancer survival rates among men, and has already reduced survival in younger males, those most affected by AIDS, according to a recent...

Blood detected in saliva of HIV-positive drug abusers. (Italy)
January 24, 1994... DATELINE: Italy HIV-positive intravenous drug abusers (IVDA) had significantly higher levels of blood in their saliva compared to healthy control subjects, in a study performed by researchers at the University of Naples, Italy ("Blood in...

Agency okays donated antibodies. (U.S. Food and Drug Administration)
January 24, 1994... DATELINE: U.S. FDA The U.S. Food and Drug Administration (FDA) has approved treating children with AIDS and certain bone -marrow transplant patients by infusing them with large doses of donated antibodies to pump up their immune systems....

Septra indicated for prevention of Pneumocystis carinii pneumonia. (U.S. Food and Drug Administration)
January 24, 1994... DATELINE: U.S. FDA Septra brand trimethoprimsulfamethoxazole (TMP-SMX) has received an indication from the U.S. Food and Drug Administration (FDA) for the prevention of Pneumocystis carinii pneumonia (PCP) in AIDS and other...

Company cutting AIDS research. (Eli Lilly and Company)
January 24, 1994... DATELINE: Eli Lilly and Company Eli Lilly and Company, Indianapolis, Indiana, has halted in-house research on HIV treatments as part of the pharmaceutical company's continuing restructuring plans, officials said. The company's AIDS...

Anti-HIV cream to be tested. (World Health Organization)
January 24, 1994... DATELINE: WHO Scientists plan to test a vaginal cream aimed at preventing women from contracting HIV during sexual intercourse. World Health Organization (WHO) researchers at the Academic Medical Center in Amsterdam, the...

New evidence found that HIV protein damages brain cells. (Scripps Research Institute, University of California, San Diego, and Boston University School of Medicine)
January 24, 1994... DATELINE: U.S. Scientists have found new evidence that a single protein of HIV may damage brain cells and lead to the impaired thinking and movement seen in some infected people. Strains of mice made to produce the protein in their...

Dementia afflicts 7.1 percent of AIDS patients in first year. (Multicenter AIDS Cohort Study)
January 24, 1994... DATELINE: Multicenter AIDS Cohort Study Twelve months after the initial diagnosis of AIDS, 7.1 percent of patients surviving will have dementia, according to a report from participants in the Multicenter AIDS Cohort Study (MACS)...

Board of Education approves parental opt-out in condom plan. (New York)
January 24, 1994... DATELINE: New York The New York Board of Education voted to prevent high school students from obtaining free condoms at school without signed permission of their parents. Two of the seven board members dissented in the late -night...