AIDS Weekly articles from February 1995

AIDS Weekly archives from February 1995

AAG spells bad news for some protease inhibitors. (alpha-1 acid glycoprotein) (2nd National Conference on Human Retroviruses and Related Infections)
February 27, 1995... A glycoprotein contained in normal human serum profoundly decreases the anti-HIV effect of several members of a new class of antiretroviral drugs. Protease inhibitors are designed to interfere with the function of an enzyme crucial to HIV...

Protease inhibitors: good news and bad news. (2nd National Conference on Human Retroviruses and Related Infections)
February 27, 1995... In the race to develop a practical inhibitor of HIV protease, Abbott and Merck have gained an early lead with Searle stumbling in the early going. The latest results from clinical and preclinical tests of several candidate protease...

ICU not justified in PCP patients with respiratory failure. (intensive care unit, Pneumocystis carinii pneumonia)
February 27, 1995... Treatment of AIDS patients with Pneumocystis carinii pneumonia and respiratory failure in hospital intensive care units (ICU) may no longer be economically justifiable, according to a report from San Francisco General Hospital. "Our study...

Improved assays shorten preseroconversion window period. (testing donated blood for HIV)
February 27, 1995... Recent improvement in the sensitivity of anti-HIV assays has considerably shortened the preseroconversion window period; thus, the incremental reduction in the window period that could be achieved with direct virus-detection assays has...

Long-term indeterminate Western blot study shows no infection. (HIV testing of blood donors)
February 27, 1995... Researchers stated that the long-term follow-up of blood donors who had indeterminate results on Western blot did not show evidence of HIV infection. J. Brooks Jackson, M.D., Case Western Reserve University School of Medicine and University...

Membrane filter is effective in removing HIV from fluids. (containing serum)
February 27, 1995... Researchers tested a membrane filter and found it to be effective in removing HIV from fluids that contain serum or serum products. Kevin H. Oshima, U.S. Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, and colleagues, in...

White House raps Pentagon for not spending research funds. (for breast cancer and AIDS research)
February 27, 1995... In a rare public scolding, the White House told the Pentagon not to hold up money earmarked for breast cancer and AIDS research. Chief of Staff Leon Panetta released a letter he sent to Defense Secretary William Perry in which he said that...

Zipper-like domain of gp41 related to HIV virus entry. (glycoprotein)
February 27, 1995... The leucine zipper-like domain of the HIV transmembrane protein gp41 does not appear to play a major role in HIV-1 envelope oligomerization, but is related to the series of events associated with virus entry, according to a report from North...

CDC warns of costly errors in "window period" negatives. (Centers for Disease Control and Prevention)
February 27, 1995... The attorney for a woman who wrongly believed for two years that she carried HIV says her case demonstrates the need for attention to the problem of inaccurate tests and their potentially shattering impact. A U.S. Centers for Disease Control...

NIAID gives go-ahead to eight test therapies for HIV. (National Institute of Allergy and Infectious Diseases)
February 27, 1995... Possibilities for using gene therapy against HIV infection are expanding, Dr. Robert E. Walker said at the annual scientific assembly of the American College of Chest Physicians. Eight studies have been approved for gene transfer in...

Urine testing for HIV as accurate as blood testing.
February 27, 1995... Two studies recently published in the Archives of Pathology and Laboratory Medicine and Clinical Infectious Diseases come to important conclusions about urine testing for HIV; it is as accurate as blood testing and plays a major role in...

In vitro response to HIV envelope seen. (in person infected with HIV for long time without progressing to AIDS)
February 27, 1995... Sera from a woman who has been HIV positive since 1981 but has not progressed to AIDS had an absence of recoverable infectious virus and a strong in vitro proliferative response to HIV envelope proteins. "Cohorts of long-term survivors and...

Anti-Id MAbs identify neutralizing anti-gp120 in HIV+. (anti-idiotype monoclonal antibodies)
February 27, 1995... Anti-idiotype monoclonal antibodies (anti-Id MAbs) may identify and measure neutralizing anti-gp120 antibodies of defined specificity in the sera of HIV positive persons. In previous studies researcher Kandasamy Hariharan and colleagues...

CDC study lists on-the-job HIV risks. (Centers for Disease Control and Prevention)
February 27, 1995... Concerns among healthcare workers about their risks of acquiring HIV infections on the job - through accidental needlesticks and other injuries involving breaks in the skin - prompted a recent U.S. Centers for Disease Control and Prevention...

Study backs HIV transfusions. (passive immunotherapy)
February 27, 1995... AIDS patients experienced some benefit, including a delay in symptoms, when treated with blood from HIV positive patients who hadn't developed the disease, French researchers say. In a study published in the February 14, 1995, issue of the...

Trimethoprim-sulfamethoxazole can be given orally.
February 27, 1995... The pharmacokinetic characteristics of trimethoprim and sulfamethoxazole appear to be similar in critically ill and non-critically ill AIDS patients, according to a report from the University of Toronto. Current dosage regimens of...

Health commission votes to end anonymous HIV testing. (North Carolina Commission for Health Services)
February 27, 1995... An AIDS activist is promising to fight a state commission's decision to end anonymous HIV testing at health departments in June 1995 and switch to exclusive use of confidential testing. The North Carolina Commission for Health Services voted...

AZT superior to ddC in initial AIDS therapy. (zidovudine, zalcitabine)
February 27, 1995... Zidovudine shows major advantages over zalcitabine in initial monotherapy for AIDS in terms of functional outcomes such as symptom impact, disability, work and health status, according to a report by the Roche Laboratories study group....

Washing birth canal may prevent mother-to-infant HIV.
February 27, 1995... Washing the birth canal with chlorhexidine may be a simple way to minimize the risk of HIV transmission from mothers to babies during birth, according to a report from Malawi, Africa. The technique was described at the Second National...

HIV showing dramatic rise among women.
February 27, 1995... More and more women are contracting HIV through heterosexual sex as the spread of the disease dramatically increases among women in the United States, health officials say. HIV cases among women are increasing by about 17 percent a year, and...

AIDS-associated Burkitt's lymphoma cell lines (AABCL) secrete IL-12. (Research Report)
February 27, 1995... According to an abstract submitted by the authors to the 36th Annual Meeting of the American Society of Hematology, held December 2-6, 1994, in Nashville, Tennessee, "IL-12 is a 70kD heterodimer formed by 40kD heavy chain (p40) and 35kD light...

CD34+ bone marrow microvascular endothelial are consistently infected by HIV-1 in patients with AIDS. (Research Report)
February 27, 1995... According to an abstract submitted by the authors to the 36th Annual Meeting of the American Society of Hematology, held December 2-6, 1994, in Nashville, Tennessee, "Bone marrow insufficiency is common in patients with AIDS and is reflected by...

HIV-1 infection is latent in primary and transformed bone marrow stromal cells. (Research Report)
February 27, 1995... According to an abstract submitted by the authors to the 36th Annual Meeting of the American Society of Hematology, held December 2-6, 1994, in Nashville, Tennessee, "Anemia, neutropenia, and thrombetopenia are evident in HIV-1 seropositive,...

Role of zidovudine (AZT) usage on subsequent development of lymphoma (NHL) in HIV infected men. (Research Report)
February 27, 1995... According to an abstract submitted by the authors to the 36th Annual Meeting of the American Society of Hematology, held December 2-6, 1994, in Nashville, Tennessee, "PURPOSE: To assess the role of zidovudine (AZT) in subsequent development of...

Risk-adapted treatment of HIV-related high grade non-Hodgkin's lymphomas with CHOP followed by IFN-alpha maintenance therapy. (cyclophosphamide, hydroxydaunomycin, Oncovorin, prednisone; interferon-alpha) (Research Report)
February 27, 1995... According to an abstract submitted by the authors to the 36th Annual Meeting of the American Society of Hematology, held December 2-6, 1994, in Nashville, Tennessee, "The majority of HIV-related non-Hodgkin s lymphomas (NHL) is of high grade...

Efficient transduction of CD34+ cells with an anti-HIV-1 ribozyme-bearing retroviral vector. (Research Report)
February 27, 1995... According to an abstract submitted by the authors to the 36th Annual Meeting of the American Society of Hematology, held December 2-6, 1994, in Nashville, Tennessee, "Previous experiments have demonstrated an efficient gene transfer of neomycin...

A comparison of fat-free mass estimates in men infected with the human immunodeficiency virus. (reprinted from Journal of Parenteral and Enteral Nutrition, Jan-Feb 1995) (Periodical Report) (Abstract)
February 27, 1995... According to the authors' abstract of an article published in Journal of Parenteral and Enteral Nutrition, "BACKGROUND: Loss of lean-body mass has been found to be predictive of death from wasting in HIV infected individuals. Several...

Retroviral recombination can lead to linkage of reverse transcriptase mutations that confer increased zidovudine resistance. (reprinted from Journal of Virology, Feb 1995) (Periodical Report) (Abstract)
February 27, 1995... According to the authors' abstract of an article published in Journal of Virology, "Inhibitors of the human immunodeficiency virus protease represent a promising new class of antiretroviral drugs for the treatment of AIDS. We now report the in...

Cytotoxic T-lymphocyte induction in asymptomatic HIV-1 infected patients immunized with Retrovector transduced autologous fibroblasts expressing HIV-1(IIIB) Env/Rev proteins. (reprinted from AIDS, Jan 1995) (Periodical Report) (Abstract)
February 27, 1995... According to the authors' abstract of an article published in AIDS, "OBJECTIVE: To demonstrate the safety and enhancement of HIV-1-specific immune responses in HIV infected asymptomatic patients following treatment with retroviral vector...

Antibodies to the putative SIV infection-enhancing domain diminish beneficial effects of an SIV gp160 vaccine in rhesus macaques. (simian immunodeficiency virus)(reprinted from AIDS, Jan 1995) (Periodical Report) (Abstract)
February 27, 1995... According to the authors' abstract of an article published in AIDS, "OBJECTIVE: To demonstrate that antibodies against amino acids (aa) 603-622 of the SIV gp41 transmembrane glycoprotein enhance infection of SIV in vivo. DESIGN: A synthetic...

CDR3-independent gamma delta V delta 1 T-cell expansion in the peripheral blood of HIV infected persons. (reprinted from Journal of Immunology, Feb 1, 1995) (Periodical Report) (Abstract)
February 27, 1995... According to the authors' abstract of an article published in Journal of Immunology, "A majority of circulating gamma delta T cells in humans express the V delta 2 variable segment associated with the V gamma 9 segment. A minor subset uses the...

Effect of sex, age and transmission category on the progression to AIDS and survival of zidovudine-treated symptomatic patients. (reprinted from AIDS, Jan 1995) (Periodical Report) (Abstract)
February 27, 1995... According to the authors' abstract of an article published in AIDS, "OBJECTIVE: To evaluate the effect of transmission category and demographic, clinical and immunological characteristics on the progression to AIDS and survival of...

Effects of second-site mutations on dominant interference by a human immunodeficiency virus type 1 envelope glycoprotein mutant. (reprinted from Journal of Virology, Feb 1995) (Periodical Report) (Abstract)
February 27, 1995... According to the authors' abstract of an article published in Journal of Virology, "We have demonstrated previously that a human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein containing a Val-to-Glu substitution at the second...

3TC AZT combination trial results called "breath of fresh air." (2nd National Conference on Human Retroviruses and Related Infections)
February 20, 1995... The combination of lamivudine (3TC) and zidovudine (AZT) has the most potent and longest lasting effect of any antiretroviral strategy yet tested in clinical trials, according to the results of four Phase II trials conducted in Europe and in...

AIDS-free survival associated with CD4 level. (2nd National Conference on Human Retroviruses and Related Infections)
February 20, 1995... Survival among HIV infected AIDS-free homosexual men is strongly associated with the level of CD4 cells, researchers from Johns Hopkins University report. The research reveals a 2.5 year survival rate of 40 percent for those with very low...

AZT protects against transmission even in very sick women. (maternal-fetal transmission) (2nd National Conference on Human Retroviruses and Related Infections)
February 20, 1995... Further evidence that zidovudine taken during pregnancy significantly reduces HIV transmission to children and that this protective effect occurs even in very sick women, is being offered by a New York City AIDS coalition. A study, conducted...

Caesarean section minimizes risk of HIV infection. (2nd National Conference on Human Retroviruses and Related Infections)
February 20, 1995... The lowest risk of HIV transmission during childbirth appears to occur during caesarean deliveries without complications, but this childbirth method is not practical for routine use in HIV infected mothers, according to a report from Columbia...

Clinical trial of transdominant Rev underway. (2nd National Conference on Human Retroviruses and Related Infections)
February 20, 1995... Three patients with HIV infection have received five transfers of autologous T cells carrying a gene construct - Rev M10 - that suppresses HIV replication without affecting T-cell function. All three patients have received transfers of at...

Compound represents new approach to anti-HIV drugs. (H-0294) (2nd National Conference on Human Retroviruses and Related Infections)
February 20, 1995... A new approach to anti-HIV drugs targets viral proteins that enable HIV to insert its genetic material in non-dividing cells. The first of this class of drugs is a compound dubbed H-0294 that is able to inhibit HIV-1 replication in...

Heterosexual transmission most common in South Bronx. (2nd National Conference on Human Retroviruses and Related Infections)
February 20, 1995... Heterosexual transmission appears to be the leading cause of new HIV infections in the Bronx, New York, according to a report from a South Bronx hospital and the U.S. Centers for Disease Control and Prevention. The study was reported January...

New Hoechst Bayer NNRTI enters clinical study. (non-nucleoside reverse transcriptase inhibitor)(quinoxaline derivative) (2nd National Conference on Human Retroviruses and Related Infections)
February 20, 1995... A new type of non-nucleoside reverse transcriptase inhibitor (NNRTI) has recently entered clinical trials, according to a report at the 2nd National Conference on Human Retroviruses and Related Infections, held January 29-February 2, 1995, in...

Rapid screening for HIV antibodies. (2nd National Conference on Human Retroviruses and Related Infections)
February 20, 1995... Two new antibody tests for HIV have been shown in recent studies to be rapid, inexpensive and accurate alternatives to tests currently in use, researchers report. The test kits are self-contained and include ready-to-use reagents in dropper...

Smoking increases oral candidiasis pneumonia in HIV+. (2nd National Conference on Human Retroviruses and Related Infections)
February 20, 1995... Cigarette smoking appears to significantly increase the likelihood and rate of development of oral candidiasis, hairy leukoplakia and bacterial pneumonia in HIV infected men, according to a report from the U.S. Centers for Disease Control and...

rgp160 shows immunogenicity in HIV-. (baculovirus recombinant glycoprotein)
February 20, 1995... Baculovirus rgp160, under study as a potential vaccine for HIV, appears to be well tolerated and to induce certain humoral and cell mediated responses, according to an AIDS Vaccine Clinical Trials Network study involving HIV negative adults....

Deficiency linked with increased HIV transmission mortality. (vitamin A deficiency; mother-fetus transmission)
February 20, 1995... An increased percentage of vertical transmission, as well as mother/child mortality, occurs in women who are deficient in vitamin A, researchers from Johns Hopkins University and Malawi, Africa, report. Vitamins are essential for normal...

Active TB may independently accelerate course of HIV. (tuberculosis)
February 20, 1995... Active tuberculosis (TB) appears to be an independent marker of advanced immunosuppression in HIV positive patients, but it also may act as a co-factor to accelerate the clinical course of HIV infection. Earlier studies suggest that HIV...

CMV pneumonia is associated with absence of AECs. (cytomegalovirus; alveolar epithelial cells)
February 20, 1995... Cytomegalovirus (CMV) pneumonia in immunocompromised individuals is associated with the absence of HLA class II antigens within the infected cells, primarily type II alveolar epithelial cells (AEC), researchers reported. Christine L....

Most AIDS patients with TB and low CD4 have atypical radiographs. (tuberculosis)
February 20, 1995... Pulmonary tuberculosis (TB) should be suspected in AIDS patients presenting with CD4 counts less than 0.20x10(9) cells/L and radiographic findings atypical for reactivation TB, according to a report from the University of Pennsylvania....

Booster HBV vaccines needed in HIV+ children. (hepatitis B virus)
February 20, 1995... Booster vaccines for hepatitis B virus (HBV) may be necessary in children infected with HIV, according to a report from New York's Mount Sinai School of Medicine. Researcher Shahana A Choudhury and colleagues previously showed that antibody...

HIV-1 encoding envelope associated with growth failure.
February 20, 1995... A murine study conducted by Mount Sinai Medical Center researchers suggests that expression of an HIV-1 proviral construct encoding envelope and regulatory genes may be associated with postnatal growth and cachexia in infants. Several...

AIDS study not to commence until FDA approval is obtained. (Food and Drug Administration; clinical testing of Reticulose)
February 20, 1995... Advanced Viral Research Corporation, Miami, Florida, announced that the U.S. Food and Drug Administration (FDA) has instructed the company to cease all activities directly related to the previously announced pilot AIDS study assessing the...

Syphilis testing is not cost-effective in detecting HIV infected antibody-negative blood donations. (Research Report)
February 20, 1995... According to an abstract presented by the authors to the 2nd National Conference on Human Retroviruses and Related Infections, held January 29 - February 2, 1995, in Washington, DC, "OBJECTIVES: Contemporary blood processing and storage...

Progress in HIV-1 vaccine development. (Research Report)
February 20, 1995... According to an abstract presented by the authors to the 2nd National Conference on Human Retroviruses and Related Infections, held January 29 - February 2, 1995, in Washington, DC, "Prophylactic vaccines for HIV-1 have been given to over 1500...

Epidemiology and biology of lung cancer in human immunodeficiency virus seropositive (HIV+) patients. (Research Report)
February 20, 1995... According to an abstract presented by the authors to the 2nd National Conference on Human Retroviruses and Related Infections, held January 29 - February 2, 1995, in Washington, DC, "Lung cancer is the leading cause of cancer deaths in the...

Universal base analogs in antisense oligodeoxinucleotides (AS ODNs): a therapeutic strategy against HIV variability. (Research Report)
February 20, 1995... According to an abstract presented by the authors to the 2nd National Conference on Human Retroviruses and Related Infections, held January 29 - February 2, 1995, in Washington, DC, "Sequence-specific activity of AS ODNs against HIV derives...

Case-control study of HIV seroconversion in health care workers (HCWs) after percutaneous exposure (PE) to HIV infected blood. (Research Report)
February 20, 1995... According to an abstract presented by the authors to the 2nd National Conference on Human Retroviruses and Related Infections, held January 29 - February 2, 1995, in Washington, DC, "OBJECTIVE: To determine risk factors for HIV seroconversion...

Co-expression of FGF3 (Int-2) and its receptor (a splice variant of FGFR2) in Kaposi's sarcoma tumors. (Research Report)
February 20, 1995... According to an abstract presented by the authors to the 2nd National Conference on Human Retroviruses and Related Infections, held January 29 - February 2, 1995, in Washington, DC, "The expression of FGF3 has recently been detected in 55% of...

Gene therapy for human immunodeficiency virus infection: combination of anti-HIV-1-Rev sFV and ribozyme to the HIV-1 RRE. (single chain variable fragments; Rev responsive element) (Research Report)
February 20, 1995... According to an abstract presented by the authors to the 2nd National Conference on Human Retroviruses and Related Infections, held January 29 - February 2, 1995, in Washington, DC, "Gene therapeutic strategies for the treatment of human...

Adoptive transfer of genetically modified cells in identical twins discordant for HIV-1 infection. (Research Report)
February 20, 1995... According to an abstract presented by the authors to the 2nd National Conference on Human Retroviruses and Related Infections, held January 29 - February 2, 1995, in Washington, DC, "BACKGROUND: As a prelude to gene therapy trials in HIV...

Use of paclitaxel (Taxol) as therapy for HIV-associated Kaposi's sarcoma (KS). (Research Report)
February 20, 1995... According to an abstract presented by the authors to the 2nd National Conference on Human Retroviruses and Related Infections, held January 29 - February 2, 1995, in Washington, DC, "Inhibitors of microtubule assembly are known to be clinically...

Inhibition of the anti-V3 response to an HIV vaccine by maternal antibody. (Research Report)
February 20, 1995... "Inhibition of the Anti-V3 Response to an HIV Vaccine by Maternal Antibody." M.T. Jelonek, J.L. Maskrey, K.S. Steimer, B.J. Potts, K.W. Higgins and M.A. Keller. Harbor-UCLA Medical Center', Torrance, California; Chiron Corp., Emeryville,...

The immunological potential of apoptotic debris produced by tumor cells and during HIV infection. (reprinted from Immunology Letters, Dec 1994) (Periodical Report) (Abstract)
February 20, 1995... According to the author's abstract of an article published in Immunology Letters, "Apoptosis is a major cause of cell death in health and disease. In contrast to necrosis, apoptosis does not induce an inflammatory response and the cellular...

Spermicides and barrier contraception. (reprinted from Current Opinion in Obstetrics & Gynecology, Dec 1994) (Periodical Report) (Abstract)
February 20, 1995... According to the authors' abstract of an article published in Current Opinion in Obstetrics & Gynecology, "The contraceptive failure rate of condoms varies from 2 to 13%, depending on the study population, yet it is the contraceptive method...

Dendritic cells from HIV-1 infected individuals show reduced capacity to stimulate autologous T-cell proliferation. (reprinted from Immunology Letters, Dec 1994) (Periodical Report) (Abstract)
February 20, 1995... According to the authors' abstract of an article published in Immunology Letters, "Dendritic cells (DC) exposed for a short period of time (1 day) in vitro to HIV infection caused stimulation of autologous T-cells, but those exposed for a...

Rapid grouping of HIV-1 infection in subtypes A to E by V3 peptide serotyping and its relation to sequence analysis. (reprinted from Biochemical and Biophysical Research Communications, Dec 30, 1994) (Periodical Report) (Abstract)
February 20, 1995... According to the authors' abstract of an article published in Biochemical and Biophysical Research Communications, "We developed a typing assay for HIV-1 using subtype specific peptides corresponding to the five major subtypes of HIV-1 (A to...

HIV-1-env specific cytotoxicity in patients with asymptomatic HIV disease before and after immunization with recombinant gp160. (reprinted from International Journal of Immunopathology and Pharmacology, Sep-Dec 1994) (Periodical Report) (Abstract)
February 20, 1995... According to the authors' abstract of an article published in International Journal of Immunopathology and Pharmacology, "Env-specific cytotoxic activity was studied in asymptomatic HIV infected patients and found in 46% of them. The in vitro...

Nosocomial infections in the human immunodeficiency virus infected patient: a 2-year survey. (reprinted from American Journal of Infection Control, Dec 1994) (Periodical Report) (Abstract)
February 20, 1995... According to the authors' abstract of an article published in American Journal of Infection Control, "BACKGROUND: Because HIV infected patients are often hospitalized and have major defects in host defenses, we surveyed all HIV infected...

Interleukin-10 inhibits initial reverse transcription of human immunodeficiency virus type 1 and mediates a virostatic latent state in primary blood-derived human macrophages in vitro. (reprinted from Journal of General Virology, Dec 1994) (Periodical Report) (Abstract)
February 20, 1995... According to the authors' abstract of an article published in Journal of General Virology, "Interleukin-10 (IL-10), a product of T lymphocytes, B cells and macrophages, participates in Th-2 immune responses and modulates macrophage functions...

Variation in the expression of human immunodeficiency virus RNA and cytokine mRNA in rectal mucosa during the progression of infection. (reprinted from Lymphokine and Cytokine Research, Dec 1994) (Periodical Report) (Abstract)
February 20, 1995... According to the authors' abstract of an article published in Lymphokine and Cytokine Research, "Previous studies demonstrated that mucosal HIV p24 antigen content varied during the progression of HIV infection. In this study, expression of...

Oral zinc supplementation in the treatment of HIV-infected children. (reprinted from Pediatric AIDS and HIV Infection - Fetus to Adolescent, Dec 1994) (Periodical Report) (Abstract)
February 20, 1995... According to the authors' abstract of an article published in Pediatric AIDS and HIV Infection - Fetus to Adolescent, "Primary zinc (Zn) deficiency has been reported to cause immune dysfunction; secondary Zn deficiency has been noted in...

Lack of association between anti-V3 loop antibodies and perinatal transmission of HIV-1 in Kampala, Uganda. (reprinted from Pediatric AIDS and HIV Infection - Fetus to Adolescent, Dec 1994) (Periodical Report) (Abstract)
February 20, 1995... According to the authors' abstract of an article published in Pediatric AIDS and HIV Infection - Fetus to Adolescent, "This study evaluated the association between reactivity of maternal antibody to human immunodeficiency virus type 1 (HIV-1)...

Construction of infectious molecular clones of HIV-1 containing defined mutations in the protease gene. (reprinted from Biochemical and Biophysical Research Communications, Dec 30, 1994) (Periodical Report) (Abstract)
February 20, 1995... According to the authors' abstract of an article published in Biochemical and Biophysical Research Communications, "A DNA clone of HIV-1 containing the full-length infectious viral sequence was cleaved at a unique Nco I restriction site within...

Retrovirus conference heralds new era. (3TC and AZT combination therapy) (2nd National Conference on Human Retroviruses and Related Infections)
February 13, 1995... Findings announced at a relatively unheralded retrovirus conference have completely changed the course of AIDS research. Coverage of the conference, the 2nd National Conference on Human Retroviruses and Related Infections, sponsored by the...

Long-term survivors have low levels of HIV-1.
February 13, 1995... Those who remain asymptomatic for many years despite HIV-1 infection have low levels of HIV-1 and a combination of strong virus-specific immune responses with some degree of attenuation of virus, according to a report from New York University's...

Ganciclovir implant for CMV retinitis results. (cytomegalovirus) (2nd National Conference on Human Retroviruses and Related Infections)
February 13, 1995... Chiron Vision, Irvine, California, reported that a Phase III clinical trial of its sustained-release intraocular ganciclovir implant demonstrated a clinically important improvement over intravenous ganciclovir in delaying the progression of...

Vistide study in CMV retinitis patients data presented. (cidofovir; cytomegalovirus) (2nd National Conference on Human Retroviruses and Related Infections)
February 13, 1995... Gilead Sciences Inc., Foster City, California, announced efficacy data from a 48-patient Phase II/III pivotal study of Vistide (cidofovir) in AIDS patients with CMV retinitis. These data were presented at the Second National Conference on...

Regional HIV seroprevalence reported. (2nd National Conference on Human Retroviruses and Related Infections)
February 13, 1995... The AIDS epidemic is sweeping out of control among crack cocaine smokers in the country's poorest neighborhoods, new data show. Several reports presented at the 2nd National Conference on Human Retroviruses and Related Infections, held in...

Data presented on ISIS 5320 anti-HIV compound. (Isis Pharmaceuticals) (2nd National Conference on Human Retroviruses and Related Infections)
February 13, 1995... Isis Pharmaceuticals, Carlsbad, California, announced that data were presented showing that ISIS 5320 inhibits HIV viral replication in the SCID-hu mouse model of HIV infection, developed by Systemix Inc. The data were presented at the 2nd...

Gallium thallium sign of mycobacterial infection in HIV+.
February 13, 1995... Thallium-gallium mismatch pattern is specific for mycobacterial infection in patients who are immunodeficient due to HIV infection, according to a report from Boston University School of Medicine. Nontuberculous mycobacterial infections...

Infection of oral mucosal cells by HIV-1 seen in HIV+.
February 13, 1995... HIV-1 provirus DNA was found in oral mucosal squamous cells and mononuclear cells in the saliva of HIV infected persons in a Beth Israel Medical Center report. Electron microscopy and polymerase chain reaction (PCR) have been used to detect...

Adrenal insufficiency reported in AIDS patients.
February 13, 1995... Columbia University Researchers report five cases of primary adrenal insufficiency seen over a two-year period in patients with AIDS. Although adrenal pathology has been found in many patients with AIDS, the connection between pathology and...

Number of AIDS cases stabilizing.
February 13, 1995... The rate at which AIDS is spreading has leveled off and the number of new cases reported every year is falling, health officials said. The report from the U.S. Centers for Disease Control and Prevention (CDC) came just three days after the...

Drug malabsorption contributes to resistance in HIV+. (drug resistance in tuberculosis patients)
February 13, 1995... Drug malabsorption may contribute to the emergence of acquired drug resistance in tuberculosis (TB) patients with HIV infection, according to a report from Hartford, Connecticut. Researcher Kalpana B. Patel and colleagues report on two HIV...

Age and thymopoiesis affect CD4+ T-lymphocyte regeneration after therapy.
February 13, 1995... Research suggests that patient age affects the contribution of the thymus to the regeneration of CD4(+) T-lymphocytes. Crystal L. Mackall et al., from the U.S. National Institutes of Health, suggest that an important step in developing...