AIDS Weekly articles from February 1995

AIDS Weekly archives from February 1995

Retrovirus conference heralds new era. (3TC and AZT combination therapy) (2nd National Conference on Human Retroviruses and Related Infections)
February 13, 1995... Findings announced at a relatively unheralded retrovirus conference have completely changed the course of AIDS research. Coverage of the conference, the 2nd National Conference on Human Retroviruses and Related Infections, sponsored by the...

Long-term survivors have low levels of HIV-1.
February 13, 1995... Those who remain asymptomatic for many years despite HIV-1 infection have low levels of HIV-1 and a combination of strong virus-specific immune responses with some degree of attenuation of virus, according to a report from New York University's...

Ganciclovir implant for CMV retinitis results. (cytomegalovirus) (2nd National Conference on Human Retroviruses and Related Infections)
February 13, 1995... Chiron Vision, Irvine, California, reported that a Phase III clinical trial of its sustained-release intraocular ganciclovir implant demonstrated a clinically important improvement over intravenous ganciclovir in delaying the progression of...

Vistide study in CMV retinitis patients data presented. (cidofovir; cytomegalovirus) (2nd National Conference on Human Retroviruses and Related Infections)
February 13, 1995... Gilead Sciences Inc., Foster City, California, announced efficacy data from a 48-patient Phase II/III pivotal study of Vistide (cidofovir) in AIDS patients with CMV retinitis. These data were presented at the Second National Conference on Human...

Regional HIV seroprevalence reported. (2nd National Conference on Human Retroviruses and Related Infections)
February 13, 1995... The AIDS epidemic is sweeping out of control among crack cocaine smokers in the country's poorest neighborhoods, new data show. Several reports presented at the 2nd National Conference on Human Retroviruses and Related Infections, held in...

Data presented on ISIS 5320 anti-HIV compound. (Isis Pharmaceuticals) (2nd National Conference on Human Retroviruses and Related Infections)
February 13, 1995... Isis Pharmaceuticals, Carlsbad, California, announced that data were presented showing that ISIS 5320 inhibits HIV viral replication in the SCID-hu mouse model of HIV infection, developed by Systemix Inc. The data were presented at the 2nd...

Gallium thallium sign of mycobacterial infection in HIV+.
February 13, 1995... Thallium-gallium mismatch pattern is specific for mycobacterial infection in patients who are immunodeficient due to HIV infection, according to a report from Boston University School of Medicine. Nontuberculous mycobacterial infections caused...

Infection of oral mucosal cells by HIV-1 seen in HIV+.
February 13, 1995... HIV-1 provirus DNA was found in oral mucosal squamous cells and mononuclear cells in the saliva of HIV infected persons in a Beth Israel Medical Center report. Electron microscopy and polymerase chain reaction (PCR) have been used to detect...

Adrenal insufficiency reported in AIDS patients.
February 13, 1995... Columbia University Researchers report five cases of primary adrenal insufficiency seen over a two-year period in patients with AIDS. Although adrenal pathology has been found in many patients with AIDS, the connection between pathology and...

Number of AIDS cases stabilizing.
February 13, 1995... The rate at which AIDS is spreading has leveled off and the number of new cases reported every year is falling, health officials said. The report from the U.S. Centers for Disease Control and Prevention (CDC) came just three days after the CDC...

Drug malabsorption contributes to resistance in HIV+. (drug resistance in tuberculosis patients)
February 13, 1995... Drug malabsorption may contribute to the emergence of acquired drug resistance in tuberculosis (TB) patients with HIV infection, according to a report from Hartford, Connecticut. Researcher Kalpana B. Patel and colleagues report on two HIV...

Age and thymopoiesis affect CD4+ T-lymphocyte regeneration after therapy.
February 13, 1995... Research suggests that patient age affects the contribution of the thymus to the regeneration of CD4(+) T-lymphocytes. Crystal L. Mackall et al., from the U.S. National Institutes of Health, suggest that an important step in developing...

Anonymous reporting improves surveillance in Denmark. (AIDS surveillance)
February 13, 1995... AIDS surveillance has been improved in Denmark by the recent introduction of an anonymous mandatory HIV reporting system for all persons testing positive for HIV, according to a report from the Danish Epidemiology Science Center. From 1990...

Nation losing interest in AIDS epidemic.
February 13, 1995... Fourteen years and more than 250,000 American deaths since AIDS began making headlines, scientists say they're worried that the nation no longer feels an urgency to treat and find a cure for AIDS. "As long as everyone believed we could find a...

Doctor lashes out at AABB for slow AIDS response. (Dr. Jeffrey Koplan; American Association of Blood Banks)
February 13, 1995... A doctor once prohibited from testifying in blood transfusion lawsuits lashed out in court at the American Association of Blood Banks (AABB), saying it did too little to stop the spread of HIV. Dr. Jeffrey Koplan, a former U.S. Centers for...

B19 viremia uncommon in some HIV+ groups. (parvovirus B19)
February 13, 1995... B19 viremia appears to be uncommon in some groups of HIV infected individuals, according to a multicenter report. Parovirus B19 has been described as a cause of chronic anemia in immunosuppressed patients, including those infected with HIV....

Disease from mycobacteria common in HIV+.
February 13, 1995... Disseminated disease from nontuberculous mycobacteria (NTM) other than Mycobacterium avium is more common than has previously been suspected in HIV-positive patients, according to a report from the U.S. Army. Approximately 97 percent of...

Parathyroid secretion is reduced in AIDS patients.
February 13, 1995... Basal and maximal secretion of parathyroid is reduced in patients with AIDS, according to a report from a Swiss research center. Several endocrine functions may be disturbed in patients infected with HIV. The adrenal gland has received the...

AIDS research evaluation ordered. (by Office of AIDS Research)
February 13, 1995... Federal health officials, hoping to find new ways to treat and prevent AIDS, are ordering a revaluation of the nation's research effort against HIV. Dr. William E. Paul, director of the Office of AIDS Research at the U.S. National Institutes...

Similar induration sizes in HIV(+) and HIV(-) PPD reactors. (purified protein derivative) (Research Report)
February 13, 1995... According to an abstract presented by the authors to the 2nd National Conference on Human Retroviruses and Related Infections, held January 29 - February 2, 1995, in Washington, DC, "OBJECTIVES: Different criteria to define induration...

Development and testing of intramuscular and mucosal genetic vaccines. (Research Report)
February 13, 1995... According to an abstract presented by the authors to Southern or Western Regional meetings of the American Federation for Clinical Research, held February 2-4, 1995, and February 8-11, 1995, in New Orleans, Louisiana and Carmel, California, "The...

Delay and limited HIV IgA production in in-utero vertically HIV-1 infected infants with rapid disease progression compared to infants infected intrapartum with slow disease progression. (immunoglobulin A) (Research Report)
February 13, 1995... According to an abstract presented by the authors to Southern or Western Regional meetings of the American Federation for Clinical Research, held February 2-4, 1995, and February 8-11, 1995, in New Orleans, Louisiana and Carmel, California,...

Improved outcome of HIV infected patients with multidrug-resistant tuberculosis (MDRTB) in a nonoutbreak setting at an inner-city hospital in New York City. (Research Report)
February 13, 1995... According to an abstract presented by the authors to the 2nd National Conference on Human Retroviruses and Related Infections, held January 29 - February 2, 1995, in Washington, DC, "Described outbreaks of MDRTB (resistance to at least isoniazid...

Improved outcomes in a cohort of HIV infected patients with multidrug resistant tuberculosis enrolled in a directly observed therapy tuberculosis program. (Research Report)
February 13, 1995... According to an abstract presented by the authors to the 2nd National Conference on Human Retroviruses and Related Infections, held January 29 - February 2, 1995, in Washington, DC, "Outbreaks of multidrug-resistant (MDR) tuberculosis (TB) with...

Twice weekly INH vs RIF and PZA for TB prophylaxis in HIV infected adults. (isoniazid, rifampin, pyrazinamide, tuberculosis) (Research Report)
February 13, 1995... According to an abstract presented by the authors to the 2nd National Conference on Human Retroviruses and Related Infections, held January 29 - February 2, 1995, in Washington, DC, "OBJECTIVE: To compare the effectiveness of 2 regimens for...

Estimated risk of HIV transmission by screened blood in the United States. (Research Report)
February 13, 1995... According to an abstract presented by the authors to the 2nd National Conference on Human Retroviruses and Related Infections, held January 29 - February 2, 1995, in Washington, DC, "OBJECTIVES: To estimate the risk of HIV transmission by...

Differences in immune responses of orally vaccinated mice with five BCG strains. (bacillus Calmette-Guerin) (Research Report)
February 13, 1995... According to a an abstract presented by the authors to the Mucosal Immunity: New Strategies for Protection against Viral and Bacterial Pathogens Keystone Symposia, held January 16-23, 1995, in Keystone, Colorado, "The induction of mucosal immune...

Expression of foreign proteins by influenza virus vectors. (Research Report)
February 13, 1995... According to a an abstract presented by the authors to the Mucosal Immunity: New Strategies for Protection against Viral and Bacterial Pathogens Keystone Symposia, held January 16-23, 1995, in Keystone, Colorado, "The development of a...

Macaque rectal mucosa: a model system for HIV rectal transmission. (Research Report)
February 13, 1995... According to a abstract presented by the authors to the Mucosal Immunity: New Strategies for Protection against Viral and Bacterial Pathogens Keystone Symposia, held January 16-23, 1995, in Keystone, Colorado, "The most common route of...

Surface-modified nanocrystalline ceramics for drug delivery applications. (reprinted from Biomaterials, Dec 1994) (Periodical Report) (Abstract)
February 13, 1995... According to the authors' abstract of an article published in Biomaterials, "Drug delivery systems comprised of various types of carriers have long been the object of pharmacological investigation. The search has been stimulated by the belief...

Inhibition of human immunodeficiency virus type-1 by retroviral vectors expressing antisense-TAR. (reprinted from Human Gene Therapy, Dec 1994) (Periodical Report) (Abstract)
February 13, 1995... According to the authors' abstract of an article published in Human Gene Therapy, "The human immunodeficiency virus type-1 (HIV-1) Tat activation response (TAR) region is essential for Tat-mediated trans-activation of the HIV-1 long terminal...

Conserved V3 loop sequences and transmission of human immunodeficiency virus type 1. (reprinted from AIDS Research and Human Retroviruses, Dec 1994) (Periodical Report) (Abstract)
February 13, 1995... According to the authors' abstract of an article published in AIDS Research and Human Retroviruses, "The third variable region (V3) of the surface glycoprotein (gp120) of envelope sequence subtype B, type 1 human immunodeficiency virus (HIV-1-B),...

Dysregulation of interleukin-7 receptor may generate loss of cytotoxic T cell response in human immunodeficiency virus type 1 infection. (reprinted from European Journal of Immunology, Dec 1994) (Periodical Report) (Abstract)
February 13, 1995... According to the authors' abstract of an article published in European Journal of Immunology, "Virus-specific cytotoxic T lymphocytes (CTL) play a crucial role in modulating an immune response against human immunodeficiency type 1 (HIV-1)...

Possibility of detecting HIV-1 in bone specimens by a PCR in a microtiter-plate assay for HIV-1. (polymerase chain reaction)(reprinted from Unfallchirurg, Dec 1994) (Periodical Report) (Abstract)
February 13, 1995... According to the authors' abstract of an article published in Unfallchirurg, "It is known that HIV can be transmitted by allogeneic bone transplantation. Hitherto neither chemical nor physical methods have existed to allow reliable disinfection...

Absence of recoverable infectious virus and unique immune responses in an asymptomatic HIV+ long-term survivor. (reprinted from AIDS Research and Human Retroviruses, Dec 1994) (Periodical Report) (Abstract)
February 13, 1995... According to the authors' abstract of an article published in AIDS Research and Human Retroviruses, "We have studied a woman with transfusion-acquired HIV who appears to have contained infectious virus to consistently undetectable levels over a...

The antigen antibody specificity exchanger: a new peptide based tool for redirecting antibodies of other specificities to recognize the V3 domain of HIV-1 gp 120. (glycoprotein)(reprinted from Biochemical and Biophysical Research Communications, Dec 15, 1994) (Periodical Report) (Abstract)
February 13, 1995... According to the authors' abstract of an article published in Biochemical and Biophysical Research Communications, "We recently showed that a synthetic peptide corresponding to the third complementary determining region of the heavy chain (CDRH3)...

Short-term effects of lipid-based parenteral nutrition in patients with acquired immunodeficiency syndrome and Pneumocystis carinii pneumonia. (reprinted from Clinical Nutrition, Dec 1994) (Periodical Report) (Abstract)
February 13, 1995... According to the authors' abstract of an article published in Clinical Nutrition, "The human immunodeficiency virus (HIV) is surrounded by a rigid membrane rich in cholesterol. Extraction of cholesterol from the virus envelope reduces its...

Adverse reactions to antituberculosis therapy in a patient with AIDS. (reprinted from Deutsche Medizinische Wochenschrift, Dec 16, 1994) (Periodical Report) (Abstract)
February 13, 1995... According to the authors' abstract of an article published in Deutsche Medizinische Wochenschrift, "A man with advanced HIV infection (CD4 lymphocytes 90/(micro)L, CD4/CD8 ratio 0.2) was admitted to hospital with fever, cough and weight loss....

Zidovudine causes early increases in mitochondrial ribonucleic acid abundance and induces ultrastructural changes in cultured mouse muscle cells. (reprinted from Laboratory Investigation, Dec 1994) (Periodical Report) (Abstract)
February 13, 1995... According to the authors' abstract of an article published in Laboratory Investigation, "BACKGROUND: Zidovudine (azidothymidine, AZT) causes a toxic mitochondrial myopathy in AIDS patients with changes in mitochondrial (mt) DNA and mitochondrial...

3TC AZT combination trial results called "breath of fresh air." (2nd National Conference on Human Retroviruses and Related Infections)
February 20, 1995... The combination of lamivudine (3TC) and zidovudine (AZT) has the most potent and longest lasting effect of any antiretroviral strategy yet tested in clinical trials, according to the results of four Phase II trials conducted in Europe and in...

AIDS-free survival associated with CD4 level. (2nd National Conference on Human Retroviruses and Related Infections)
February 20, 1995... Survival among HIV infected AIDS-free homosexual men is strongly associated with the level of CD4 cells, researchers from Johns Hopkins University report. The research reveals a 2.5 year survival rate of 40 percent for those with very low CD4...

AZT protects against transmission even in very sick women. (maternal-fetal transmission) (2nd National Conference on Human Retroviruses and Related Infections)
February 20, 1995... Further evidence that zidovudine taken during pregnancy significantly reduces HIV transmission to children and that this protective effect occurs even in very sick women, is being offered by a New York City AIDS coalition. A study, conducted...

Caesarean section minimizes risk of HIV infection. (2nd National Conference on Human Retroviruses and Related Infections)
February 20, 1995... The lowest risk of HIV transmission during childbirth appears to occur during caesarean deliveries without complications, but this childbirth method is not practical for routine use in HIV infected mothers, according to a report from Columbia...

Clinical trial of transdominant Rev underway. (2nd National Conference on Human Retroviruses and Related Infections)
February 20, 1995... Three patients with HIV infection have received five transfers of autologous T cells carrying a gene construct - Rev M10 - that suppresses HIV replication without affecting T-cell function. All three patients have received transfers of at least...

Compound represents new approach to anti-HIV drugs. (H-0294) (2nd National Conference on Human Retroviruses and Related Infections)
February 20, 1995... A new approach to anti-HIV drugs targets viral proteins that enable HIV to insert its genetic material in non-dividing cells. The first of this class of drugs is a compound dubbed H-0294 that is able to inhibit HIV-1 replication in macrophages...

Heterosexual transmission most common in South Bronx. (2nd National Conference on Human Retroviruses and Related Infections)
February 20, 1995... Heterosexual transmission appears to be the leading cause of new HIV infections in the Bronx, New York, according to a report from a South Bronx hospital and the U.S. Centers for Disease Control and Prevention. The study was reported January...

New Hoechst Bayer NNRTI enters clinical study. (non-nucleoside reverse transcriptase inhibitor)(quinoxaline derivative) (2nd National Conference on Human Retroviruses and Related Infections)
February 20, 1995... A new type of non-nucleoside reverse transcriptase inhibitor (NNRTI) has recently entered clinical trials, according to a report at the 2nd National Conference on Human Retroviruses and Related Infections, held January 29-February 2, 1995, in...

Rapid screening for HIV antibodies. (2nd National Conference on Human Retroviruses and Related Infections)
February 20, 1995... Two new antibody tests for HIV have been shown in recent studies to be rapid, inexpensive and accurate alternatives to tests currently in use, researchers report. The test kits are self-contained and include ready-to-use reagents in dropper...

Smoking increases oral candidiasis pneumonia in HIV+. (2nd National Conference on Human Retroviruses and Related Infections)
February 20, 1995... Cigarette smoking appears to significantly increase the likelihood and rate of development of oral candidiasis, hairy leukoplakia and bacterial pneumonia in HIV infected men, according to a report from the U.S. Centers for Disease Control and...

rgp160 shows immunogenicity in HIV-. (baculovirus recombinant glycoprotein)
February 20, 1995... Baculovirus rgp160, under study as a potential vaccine for HIV, appears to be well tolerated and to induce certain humoral and cell mediated responses, according to an AIDS Vaccine Clinical Trials Network study involving HIV negative adults....

Deficiency linked with increased HIV transmission mortality. (vitamin A deficiency; mother-fetus transmission)
February 20, 1995... An increased percentage of vertical transmission, as well as mother/child mortality, occurs in women who are deficient in vitamin A, researchers from Johns Hopkins University and Malawi, Africa, report. Vitamins are essential for normal...

Active TB may independently accelerate course of HIV. (tuberculosis)
February 20, 1995... Active tuberculosis (TB) appears to be an independent marker of advanced immunosuppression in HIV positive patients, but it also may act as a co-factor to accelerate the clinical course of HIV infection. Earlier studies suggest that HIV...

CMV pneumonia is associated with absence of AECs. (cytomegalovirus; alveolar epithelial cells)
February 20, 1995... Cytomegalovirus (CMV) pneumonia in immunocompromised individuals is associated with the absence of HLA class II antigens within the infected cells, primarily type II alveolar epithelial cells (AEC), researchers reported. Christine L....

Most AIDS patients with TB and low CD4 have atypical radiographs. (tuberculosis)
February 20, 1995... Pulmonary tuberculosis (TB) should be suspected in AIDS patients presenting with CD4 counts less than 0.20x10(9) cells/L and radiographic findings atypical for reactivation TB, according to a report from the University of Pennsylvania....

Booster HBV vaccines needed in HIV+ children. (hepatitis B virus)
February 20, 1995... Booster vaccines for hepatitis B virus (HBV) may be necessary in children infected with HIV, according to a report from New York's Mount Sinai School of Medicine. Researcher Shahana A Choudhury and colleagues previously showed that antibody...

HIV-1 encoding envelope associated with growth failure.
February 20, 1995... A murine study conducted by Mount Sinai Medical Center researchers suggests that expression of an HIV-1 proviral construct encoding envelope and regulatory genes may be associated with postnatal growth and cachexia in infants. Several clinical...

AIDS study not to commence until FDA approval is obtained. (Food and Drug Administration; clinical testing of Reticulose)
February 20, 1995... Advanced Viral Research Corporation, Miami, Florida, announced that the U.S. Food and Drug Administration (FDA) has instructed the company to cease all activities directly related to the previously announced pilot AIDS study assessing the effects...

Syphilis testing is not cost-effective in detecting HIV infected antibody-negative blood donations. (Research Report)
February 20, 1995... According to an abstract presented by the authors to the 2nd National Conference on Human Retroviruses and Related Infections, held January 29 - February 2, 1995, in Washington, DC, "OBJECTIVES: Contemporary blood processing and storage...

Progress in HIV-1 vaccine development. (Research Report)
February 20, 1995... According to an abstract presented by the authors to the 2nd National Conference on Human Retroviruses and Related Infections, held January 29 - February 2, 1995, in Washington, DC, "Prophylactic vaccines for HIV-1 have been given to over 1500...

Epidemiology and biology of lung cancer in human immunodeficiency virus seropositive (HIV+) patients. (Research Report)
February 20, 1995... According to an abstract presented by the authors to the 2nd National Conference on Human Retroviruses and Related Infections, held January 29 - February 2, 1995, in Washington, DC, "Lung cancer is the leading cause of cancer deaths in the United...

Universal base analogs in antisense oligodeoxinucleotides (AS ODNs): a therapeutic strategy against HIV variability. (Research Report)
February 20, 1995... According to an abstract presented by the authors to the 2nd National Conference on Human Retroviruses and Related Infections, held January 29 - February 2, 1995, in Washington, DC, "Sequence-specific activity of AS ODNs against HIV derives from...

Case-control study of HIV seroconversion in health care workers (HCWs) after percutaneous exposure (PE) to HIV infected blood. (Research Report)
February 20, 1995... According to an abstract presented by the authors to the 2nd National Conference on Human Retroviruses and Related Infections, held January 29 - February 2, 1995, in Washington, DC, "OBJECTIVE: To determine risk factors for HIV seroconversion in...

Co-expression of FGF3 (Int-2) and its receptor (a splice variant of FGFR2) in Kaposi's sarcoma tumors. (Research Report)
February 20, 1995... According to an abstract presented by the authors to the 2nd National Conference on Human Retroviruses and Related Infections, held January 29 - February 2, 1995, in Washington, DC, "The expression of FGF3 has recently been detected in 55% of...

Gene therapy for human immunodeficiency virus infection: combination of anti-HIV-1-Rev sFV and ribozyme to the HIV-1 RRE. (single chain variable fragments; Rev responsive element) (Research Report)
February 20, 1995... According to an abstract presented by the authors to the 2nd National Conference on Human Retroviruses and Related Infections, held January 29 - February 2, 1995, in Washington, DC, "Gene therapeutic strategies for the treatment of human...

Adoptive transfer of genetically modified cells in identical twins discordant for HIV-1 infection. (Research Report)
February 20, 1995... According to an abstract presented by the authors to the 2nd National Conference on Human Retroviruses and Related Infections, held January 29 - February 2, 1995, in Washington, DC, "BACKGROUND: As a prelude to gene therapy trials in HIV...

Use of paclitaxel (Taxol) as therapy for HIV-associated Kaposi's sarcoma (KS). (Research Report)
February 20, 1995... According to an abstract presented by the authors to the 2nd National Conference on Human Retroviruses and Related Infections, held January 29 - February 2, 1995, in Washington, DC, "Inhibitors of microtubule assembly are known to be clinically...

Inhibition of the anti-V3 response to an HIV vaccine by maternal antibody. (Research Report)
February 20, 1995... "Inhibition of the Anti-V3 Response to an HIV Vaccine by Maternal Antibody." M.T. Jelonek, J.L. Maskrey, K.S. Steimer, B.J. Potts, K.W. Higgins and M.A. Keller. Harbor-UCLA Medical Center', Torrance, California; Chiron Corp., Emeryville,...

The immunological potential of apoptotic debris produced by tumor cells and during HIV infection. (reprinted from Immunology Letters, Dec 1994) (Periodical Report) (Abstract)
February 20, 1995... According to the author's abstract of an article published in Immunology Letters, "Apoptosis is a major cause of cell death in health and disease. In contrast to necrosis, apoptosis does not induce an inflammatory response and the cellular...

Spermicides and barrier contraception. (reprinted from Current Opinion in Obstetrics & Gynecology, Dec 1994) (Periodical Report) (Abstract)
February 20, 1995... According to the authors' abstract of an article published in Current Opinion in Obstetrics & Gynecology, "The contraceptive failure rate of condoms varies from 2 to 13%, depending on the study population, yet it is the contraceptive method with...

Dendritic cells from HIV-1 infected individuals show reduced capacity to stimulate autologous T-cell proliferation. (reprinted from Immunology Letters, Dec 1994) (Periodical Report) (Abstract)
February 20, 1995... According to the authors' abstract of an article published in Immunology Letters, "Dendritic cells (DC) exposed for a short period of time (1 day) in vitro to HIV infection caused stimulation of autologous T-cells, but those exposed for a longer...

Rapid grouping of HIV-1 infection in subtypes A to E by V3 peptide serotyping and its relation to sequence analysis. (reprinted from Biochemical and Biophysical Research Communications, Dec 30, 1994) (Periodical Report) (Abstract)
February 20, 1995... According to the authors' abstract of an article published in Biochemical and Biophysical Research Communications, "We developed a typing assay for HIV-1 using subtype specific peptides corresponding to the five major subtypes of HIV-1 (A to E)....

HIV-1-env specific cytotoxicity in patients with asymptomatic HIV disease before and after immunization with recombinant gp160. (reprinted from International Journal of Immunopathology and Pharmacology, Sep-Dec 1994) (Periodical Report) (Abstract)
February 20, 1995... According to the authors' abstract of an article published in International Journal of Immunopathology and Pharmacology, "Env-specific cytotoxic activity was studied in asymptomatic HIV infected patients and found in 46% of them. The in vitro...

Nosocomial infections in the human immunodeficiency virus infected patient: a 2-year survey. (reprinted from American Journal of Infection Control, Dec 1994) (Periodical Report) (Abstract)
February 20, 1995... According to the authors' abstract of an article published in American Journal of Infection Control, "BACKGROUND: Because HIV infected patients are often hospitalized and have major defects in host defenses, we surveyed all HIV infected patients...

Interleukin-10 inhibits initial reverse transcription of human immunodeficiency virus type 1 and mediates a virostatic latent state in primary blood-derived human macrophages in vitro. (reprinted from Journal of General Virology, Dec 1994) (Periodical Report) (Abstract)
February 20, 1995... According to the authors' abstract of an article published in Journal of General Virology, "Interleukin-10 (IL-10), a product of T lymphocytes, B cells and macrophages, participates in Th-2 immune responses and modulates macrophage functions...

Variation in the expression of human immunodeficiency virus RNA and cytokine mRNA in rectal mucosa during the progression of infection. (reprinted from Lymphokine and Cytokine Research, Dec 1994) (Periodical Report) (Abstract)
February 20, 1995... According to the authors' abstract of an article published in Lymphokine and Cytokine Research, "Previous studies demonstrated that mucosal HIV p24 antigen content varied during the progression of HIV infection. In this study, expression of HIV...

Oral zinc supplementation in the treatment of HIV-infected children. (reprinted from Pediatric AIDS and HIV Infection - Fetus to Adolescent, Dec 1994) (Periodical Report) (Abstract)
February 20, 1995... According to the authors' abstract of an article published in Pediatric AIDS and HIV Infection - Fetus to Adolescent, "Primary zinc (Zn) deficiency has been reported to cause immune dysfunction; secondary Zn deficiency has been noted in...

Lack of association between anti-V3 loop antibodies and perinatal transmission of HIV-1 in Kampala, Uganda. (reprinted from Pediatric AIDS and HIV Infection - Fetus to Adolescent, Dec 1994) (Periodical Report) (Abstract)
February 20, 1995... According to the authors' abstract of an article published in Pediatric AIDS and HIV Infection - Fetus to Adolescent, "This study evaluated the association between reactivity of maternal antibody to human immunodeficiency virus type 1 (HIV-1) V3...

Construction of infectious molecular clones of HIV-1 containing defined mutations in the protease gene. (reprinted from Biochemical and Biophysical Research Communications, Dec 30, 1994) (Periodical Report) (Abstract)
February 20, 1995... According to the authors' abstract of an article published in Biochemical and Biophysical Research Communications, "A DNA clone of HIV-1 containing the full-length infectious viral sequence was cleaved at a unique Nco I restriction site within...

AAG spells bad news for some protease inhibitors. (alpha-1 acid glycoprotein) (2nd National Conference on Human Retroviruses and Related Infections)
February 27, 1995... A glycoprotein contained in normal human serum profoundly decreases the anti-HIV effect of several members of a new class of antiretroviral drugs. Protease inhibitors are designed to interfere with the function of an enzyme crucial to HIV...

Protease inhibitors: good news and bad news. (2nd National Conference on Human Retroviruses and Related Infections)
February 27, 1995... In the race to develop a practical inhibitor of HIV protease, Abbott and Merck have gained an early lead with Searle stumbling in the early going. The latest results from clinical and preclinical tests of several candidate protease inhibitors...

ICU not justified in PCP patients with respiratory failure. (intensive care unit, Pneumocystis carinii pneumonia)
February 27, 1995... Treatment of AIDS patients with Pneumocystis carinii pneumonia and respiratory failure in hospital intensive care units (ICU) may no longer be economically justifiable, according to a report from San Francisco General Hospital. "Our study...

Improved assays shorten preseroconversion window period. (testing donated blood for HIV)
February 27, 1995... Recent improvement in the sensitivity of anti-HIV assays has considerably shortened the preseroconversion window period; thus, the incremental reduction in the window period that could be achieved with direct virus-detection assays has...

Long-term indeterminate Western blot study shows no infection. (HIV testing of blood donors)
February 27, 1995... Researchers stated that the long-term follow-up of blood donors who had indeterminate results on Western blot did not show evidence of HIV infection. J. Brooks Jackson, M.D., Case Western Reserve University School of Medicine and University...

Membrane filter is effective in removing HIV from fluids. (containing serum)
February 27, 1995... Researchers tested a membrane filter and found it to be effective in removing HIV from fluids that contain serum or serum products. Kevin H. Oshima, U.S. Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, and colleagues, in...