AIDS Weekly articles from December 2003

AIDS Weekly archives from December 2003

IL-7 safely stimulates T-cell renewal in SIV-infected macaques.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- Interleukin (IL)-7 safely stimulates T-cell renewal in macaques infected with the simian version of HIV (SIV). "The main failure of antiretroviral therapy is the lack of restoration of HIV-specific...

Alpha1-antitrypsin gene mutations may raise HIV infection risk.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- Polymorphisms in the AAT gene may heighten carriers' susceptibility to HIV infection. In a recent study, scientists in Australia "sought to determine whether variants of the human alpha1-antitrypsin...

Heat-denatured signal-amplified HIV p24 assay suitable for use in developing areas.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- The heat-denatured signal-amplified p24 antigen HIV assay is suitable for use in developing regions. This assay "is a low-cost test allowing the determination of plasma levels of HIV-1 p24 antigen...

Novel molecular HIV test has single-copy sensitivity for viral RNA.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- A novel molecular HIV test has single-copy sensitivity for viral RNA. According to published research from the United States, "More sensitive assays for human immunodeficiency virus type 1 (HIV-1)...

Elevated cytokine levels in adipose tissue suppress adiponectin output in HALS patients.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- Elevated cytokine levels in adipose tissue suppress adiponectin activity in HIV lipodystrophy patients. According to published research from Denmark, "Human immunodeficiency virus (HIV)-associated...

Long-term HAART does not lead to full T-cell recovery.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- Long-term HAART regimens do not induce full T-cell recovery in HIV patients. "In most HIV-1-infected patients, highly active antiretroviral therapy (HAART) reduces plasma viral load to To...

Bisexuality, abuse, drugs behind AIDS spread among South's rural blacks.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- Health officials have struggled for years to understand why blacks across the rural South are contracting AIDS at a faster rate than whites. A research scientist at the University of Alabama has...

China can use lessons from anti-SARS battle to take on AIDS, U.N. expert says.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- The lessons China learned in beating back SARS earlier this year can help it fight its AIDS epidemic - as long as the central government keeps providing quick and honest information, the head of the...

High-dose methadone linked to QT prolongation and Torsades de Pointes in HIV patients.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- High-dose methadone therapy may cause QT prolongation and Torsades de Pointes in HIV patients. According to published research from Spain, "Four patients infected with human immunodeficiency virus...

New TB vaccine shows promise in people with AIDS.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- An innovative vaccine against tuberculosis has shown promise in people with HIV, researchers from Dartmouth Medical School and the National Public Health Institute of Finland report. An...

Biopharma company announces third quarter 2003 financial results.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- GenVec, Inc., (GNVC), a biopharmaceutical company, announced financial results for the third quarter ended September 30, 2003. GenVec reported higher revenues and a lower net loss through the first...

Company reports record first quarter sales of VScan test kits.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- Medical Services International, Inc., (MSITF) announced that it has sold VScan test kits worth US$268,000 in the first quarter (period ending September 30, 2003) of its current fiscal year. This...

Lipid-focused company reports improved results in third quarter.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- Lipid Sciences, Inc., (LIPD) reported results for the third quarter and 9 months ended September 30, 2003. Lipid Sciences is a development-stage biotechnology company that is conducting research...

Ravuconazole, voriconazole, and albaconazole are active against Chaetomium.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- Antifungals ravuconazole, voriconazole, albaconazole, but not micafungin, are active against Chaetomium. "Chaetomium is an unusual etiological agent of human infections, but the mortality rate...

Human genes involved in HIV life cycle have high alternate splicing rates.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- Human genes involved in the HIV life cycle have high alternate splicing rates. "Alternative splicing may generate splice forms with different biologic roles or missing protein domains implicated in...

Investigational device exemption application submitted for HIV-1 test.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- Calypte Biomedical Corporation (CYPT), the developer and marketer of the only two U.S. Food and Drug Administration (FDA) approved HIV-1 antibody tests for use with urine samples, announced that it is...

Gene vector for HIV cleared to begin phase I/II trial.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- Enzo Biochem, Inc., (ENZ) announced that Enzo Therapeutics, its wholly owned subsidiary, has been cleared to proceed with a phase I/II study of its Stealth Vector HGTV43 gene construct for HIV infection...

Preclinical development program initiated for new HIV vaccine candidate.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- The Immune Response Corporation (IMNR) has initiated a preclinical development program with IR103, a new vaccine candidate for the prevention and treatment of HIV, the virus that causes AIDS. The...

HIV-related preventive behavior in U.S. improves in many population groups.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- Data from national surveys conducted in the United States from 1987-2002 indicate that adolescents and adults in certain populations remain at high risk for transmitting or acquiring HIV infection. ...

Oxidative stress likely involved in early HIV Tat-related neurodegeneration.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- Oxidative stress appears to play a key role in the development of HIV Tat-induced neurodegeneration. "HIV-1 transactivating protein Tat is neurotoxic and is believed to play a role in the...

Despite high cost, PCR assay for group O HIV suitable for use in endemic areas.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- Despite its high cost, a polymerase chain reaction (PCR)-based test for group O HIV may improve viral load measurements in endemic areas. "HIV-1 group O infections remains essentially restricted to...

Children left motherless by AIDS in U.S. drops from 1978 to 1998.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- The number of children left motherless by AIDS in the United States has dropped from 1978 to 1998. According to recent research from the United States, "When a mother dies of AIDS, basic needs of...

HIV Nef signaling - but not trafficking - underlies impaired T-cell development.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- HIV Nef signaling - but not trafficking - underlies Nef-induced inhibition of T-cell development "The HIV-1 gene nef is important for progression toward AIDS and cellular depletion of the infected...

HIV Nef's ability to downregulate MHC-I molecules key to viral immune escape.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- HIV Nef's ability to downregulate MHC-I molecules plays a key role in viral immune escape. "Nef is an HIV-1 protein that is absent in most retroviruses, yet its reading frame is highly maintained...

HIV Tat interacts with distinct proteasomal alpha and beta subunits.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- HIV Tat interacts with distinct cellular proteasome alpha and beta subunits. "The human immunodeficiency virus-1 (HIV-1) Tat protein was previously reported to compete the association of PA28...

Educational program fails to improve adherence to HIV treatment in minority patients.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- A novel educational intervention does not improve adherence to HIV treatment in minority patients. According to published research from Texas, "A 24-week open-label clinical trial was conducted in...

Expanded HIV care needed for aborigines and women in Canada.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- Greater efforts are needed to provide HIV care to aborigines and women in Canada. In a recent study, scientists there "evaluated all human immunodeficiency virus (HIV)-related deaths over the period...

HAART effective for pediatric HIV patients.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- Highly active antiretroviral therapy (HAART) is effective for pediatric HIV patients. According to published research from Spain, "An observational study was performed involving 95 children with...

LC/MS/MS assay suitable for measuring atazanavir levels in peripheral blood.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- A novel liquid chromatography-tandem mass spectrometric assay provides accurate and highly sensitive measurements of atazanavir levels in peripheral blood. According to published research from the...

Negative effects of saquinavir hard gel treatment subside over time.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- The negative effects of saquinavir hard gel treatment on the overall outcome of HIV therapy subside over time. "Saquinavir hard gel capsule (hgc), the first human immunodeficiency virus (HIV)...

Rituximab shows promise for HIV patients with Castleman disease.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- The anti-CD20 monoclonal antibody rituximab shows promise for the treatment of Castleman disease in HIV patients. According to a study from France, "To assess the clinical benefit of rituximab for...

Whole milk component of breast milk carries highest HIV load.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- The whole milk component of breast milk carries the highest HIV load. Scientists in the United States conducted a study "to determine which of the four components of breast milk (whole milk, skim...

Attenuated FIV vaccine protects against systemic or mucosal challenge.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- An attenuated FIV vaccine provided protection from an intraclade challenge administered systemically or mucosally. "Feline immunodeficiency virus (FM) infection of domestic cats represents a...

China offers free treatment to AIDS patients with financial woes.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- China says it will provide free treatment to thousands of HIV and AIDS patients in severe financial straits to help combat the spread of the disease. About 5000 HIV and AIDS patients with "financial...

Mycobacterium xenopi treatment is unnecessary for HIV patients on HAART.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- Mycobacterium xenopi treatment is unnecessary for HIV patients on HAART. Scientists in England described "treatment decisions and outcomes for 20 patients" with confirmed, symptomatic M. xenopi...

Patent expands adeno-associated virus manufacturing processes and technology.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- Targeted Genetics Corporation (TGEN) announced the issuance of an additional patent related to its adeno-associated virus (AAV) vector production technology. U.S. patent #9,180,114, titled...

Potential low-cost options for monitoring disease status described.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- Authors of a research letter highlight how assessment of total blood lymphocyte count and albumen concentrations could have potential as low-cost alternatives in assessing the disease status of...

AIDS epidemic should be treated as a disaster.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- In September, the World Health Organization (WHO) declared the HIV/AIDS epidemic a global health emergency requiring a rapid scaled-up treatment response, but researchers argue that governments should...

UNAIDS welcomes Canada's move to implement WTO pact on generic medicines.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- The U.N. AIDS organization, UNAIDS, welcomed draft legislation introduced by the Canadian government that would amend the country's patent laws to allow drug makers to manufacture and export lower-cost...

WHO steps up action against fake medicines.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- The World Health Organization (WHO) has launched a drive against counterfeit drugs in Southeast Asia, where it is feared that millions of people are being duped by fake and potentially dangerous drugs...

Amplified ribosomal DNA restriction analysis useful for identifying M. tuberculosis.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- Amplified ribosomal DNA restriction analysis (ARDRA) is useful for distinguishing between Mycobacterium tuberculosis and non-tuberculous mycobacteria. In a recent study from Norway, researchers...

Benzothiazolesulfonamides with potent activity against HIV protease synthesized.
December 8, 2003... 2003 DEC 8 - (NewsRx.com & NewsRx.net) -- Benzothiazolesulfonamides with potent activity against a key HIV enyzme have been synthesized. According to published research from Missouri, "The HIV virus encodes for a unique aspartyl protease...

AZT has cytotoxic effects on placenta in pregnant women.
December 8, 2003... 2003 DEC 8 - (NewsRx.com & NewsRx.net) -- AZT treatment can have toxic effects on the placenta in pregnant recipients. "The anti-HIV drug 3'-azido-3'-deoxythymidine (AZT) is the drug of choice for preventing maternal-fetal HIV transmission...

Ritonavir derivatives have potent anti-HIV activity, despite poor pharmacokinetics.
December 8, 2003... 2003 DEC 8 - (NewsRx.com & NewsRx.net) -- A series of ritonavir derivatives possess potent anti-HIV activity, despite their poor pharmacokinetics. "Isopropyl substituted 4-thioazolyl valine side chains are highly optimized P-2-P-3 ligands...

Simplified ViroSeq HIV genotype test retains accuracy.
December 8, 2003... 2003 DEC 8 - (NewsRx.com & NewsRx.net) -- A modified version of the ViroSeq HIV genotype assay simplifies the test process without compromising accuracy. "Genotypic testing for HIV-1 resistance to anti-retroviral drugs has become accepted...

Fluorescence-based assay aids screening of potential HIV RT RNase H inhibitors.
December 8, 2003... 2003 DEC 8 - (NewsRx.com & NewsRx.net) -- A novel fluorescence-based assay may aid the search for agents that can suppress HIV RT ribonuclease H (RNase H) activity. In a recent study from the United States, "A fluorescence resonance energy...

Ritonavir and indinavir inhibit calpain activity.
December 8, 2003... 2003 DEC 8 - (NewsRx.com & NewsRx.net) -- Several antiretroviral agents strongly inhibit calpain activity, and may thus have therapeutic use for patients with calpain-related degenerative disorders. "Treatment with drugs designed to...

China's AIDS epidemic is reaching "frightening" levels, renowned expert says.
December 8, 2003... 2003 DEC 8 - (NewsRx.com & NewsRx.net) -- The number of AIDS patients in China is reaching "frightening" levels, a renowned expert on the disease said, after Beijing said it would provide free treatment to thousands of sufferers in dire...

Fewer AIDS babies born in U.S. but worldwide transmissions remain epidemic.
December 8, 2003... 2003 DEC 8 - (NewsRx.com & NewsRx.net) -- The World Health Organization estimates that about 800,000 infants become infected with HIV each year around the globe, mainly through mother-to-child transmission, which can occur during pregnancy and...

Study: About 4.5 million Indians have HIV.
December 8, 2003... 2003 DEC 8 - (NewsRx.com & NewsRx.net) -- The virus that causes AIDS is being spread through India's general population mainly by married men who have unprotected sex with prostitutes, according to a new study. About 610,000 Indians...

AIDS vaccine trials begin in South Africa, Switzerland.
December 8, 2003... 2003 DEC 8 - (NewsRx.com & NewsRx.net) -- The International AIDS Vaccine Initiative (IAVI) has begun human trials in South Africa and Switzerland to test HIVA.MVA, a candidate vaccine to prevent people uninfected with HIV/AIDS from contracting...

Experimental AIDS vaccine didn't stop HIV.
December 8, 2003... 2003 DEC 8 - (NewsRx.com & NewsRx.net) -- An experimental AIDS vaccine tested in Thailand on some 2500 drug users failed to protect them from becoming infected with HIV, the vaccine's developer says. The poor results were widely expected...

VScan maker receives IRB approval for live testing.
December 8, 2003... 2003 DEC 8 - (NewsRx.com & NewsRx.net) -- On October 30, 2003, Medical Services International, Inc., (MSITF) announced that the company had agreed to begin live testing in south Florida in conjunction with the company's accelerated efforts to...

Clinical isolate fungi are mostly Candida; only amphotericin B acts on all.
December 8, 2003... 2003 DEC 8 - (NewsRx.com & NewsRx.net) -- Fungal isolates from hospital patients are predominantly Candida; most are susceptibility to amphotericin B, but fewer are to other agents. "The aim of this study was to analyze the type and...

High theoretical risk of HIV, HCV transmission for forensic pathologists.
December 8, 2003... 2003 DEC 8 - (NewsRx.com & NewsRx.net) -- Forensic pathologists have a high theoretical risk of work-related HIV and/or hepatitis C virus (HCV) infection. "Using a cumulative probability analysis and published data," researchers in the...

Positive preliminary results reported on AVR118.
December 8, 2003... 2003 DEC 8 - (NewsRx.com & NewsRx.net) -- Advanced Viral Research Corp. (ADVR) reported that preliminary results from the first 15 cachectic (wasting) AIDS patients treated with the company's novel immunomodulator AVR118 showed improvement in...

The zinc-chelating agent disulfiram may have anticancer applications.
December 8, 2003... 2003 DEC 8 - (NewsRx.com & NewsRx.net) -- The zinc-chelating agent disulfiram may have anticancer applications. According to published research from Taiwan, "cell invasion and angiogenesis are crucial processes in cancer metastasis that...

MWG Biotech announces agreement to automate HIV and HCV viral load assays.
December 8, 2003... 2003 DEC 8 - (NewsRx.com & NewsRx.net) -- MWG Biotech (NWU) announced the signing of a contractual framework with the diagnostics division of Bayer HealthCare, LLC, through its Canadian affiliate Bayer, Inc., and its Irish affiliate Bayer...

New York Assembly pushes for state oversight of prison healthcare.
December 8, 2003... 2003 DEC 8 - (NewsRx.com & NewsRx.net) -- New York's Democratic state legislators and prisoner advocates promoted legislation on November 14, 2003, to give the state Health Department oversight over some aspects of the healthcare system for the...

Brain damage found in HIV patients on antiretroviral therapy.
December 8, 2003... 2003 DEC 8 - (NewsRx.com & NewsRx.net) -- Researchers have found significant damage in the brains of HIV-positive patients whose viral load is effectively suppressed by antiretroviral therapy. In one of the first studies of its kind,...

Company receives exclusive rights to medical testing devices, supplies 10-minute HIV test.
December 8, 2003... 2003 DEC 8 - (NewsRx.com & NewsRx.net) -- QT 5, Inc., (QTFV) has finalized the exclusive worldwide rights to market an innovative line of rapid-result blood and urine test products. The diagnostic platform has been specifically designed for...

Improved stavudine derivatives developed.
December 8, 2003... 2003 DEC 8 - (NewsRx.com & NewsRx.net) -- Enhanced derivatives of the HIV reverse transcriptase inhibitor stavudine have been developed. In a recent study from Japan, "Compounds having methyl, vinyl, and ethynyl groups at the 4'-position...

Host range of feline leukemia virus A could include human, as seen in vitro.
December 8, 2003... 2003 DEC 8 - (NewsRx.com & NewsRx.net) -- Host range of feline leukemia virus A (not B or C) can include human, in vitro: embryonic kidney cells are susceptible to infection if entry barrier is broken. According to published research from...

AIDS vaccine developer reports increased cash due to financing.
December 8, 2003... 2003 DEC 8 - (NewsRx.com & NewsRx.net) -- Epimmune, Inc., (EPMN) announced its financial results for the third quarter ended September 30, 2003. During the quarter, cash and cash equivalents increased by $2.2 million to an ending balance...

ESTRASORB maker announces increased third quarter revenue.
December 8, 2003... 2003 DEC 8 - (NewsRx.com & NewsRx.net) -- Novavax, Inc., (NVAX) announced financial results for the third quarter ended September 30, 2003. Total revenues for the third quarter of 2003 were $4.3 million compared to third-quarter 2002...

CYC202 has beneficial effects in kidney disease models.
December 8, 2003... 2003 DEC 8 - (NewsRx.com & NewsRx.net) -- Cyclacel, Ltd., announced encouraging results by independent American and German investigators testing its CYC202 experimental CDK inhibitor drug in models of two variants of glomerulonephritis:...

Elements of green tea prevent HIV from binding to human T cells.
December 8, 2003... 2003 DEC 8 - (NewsRx.com & NewsRx.net) -- The major component of green tea prevents the binding of HIV to human T cells, the first step in HIV infection, according to a study and an accompanying editorial published in the November 2003 Journal...

Company to donate HIV-1 lab tests to AIDS clinic in Africa.
December 8, 2003... 2003 DEC 8 - (NewsRx.com & NewsRx.net) -- The U.S. and South African operators of the Ithembalabantu (Zulu for "people's hope") Clinic have entered into a new partnership with Primagen Holding B.V. through which Primagen will donate its Retina...

Hypermethalation of MGMT, DAP-K underlie immunodeficiency-related lymphomas.
December 8, 2003... 2003 DEC 8 - (NewsRx.com & NewsRx.net) -- Amedeo Avogadro University of Eastern Piedmont Hypermethalation of MGMT and/or DAP-K frequently underlie immunodeficiency-related lymphomas. "Aberrant promoter hypermethylation is a mechanism...

Newly approved rapid HIV-1 test is really rapid.
December 8, 2003... 2003 DEC 8 - (NewsRx.com & NewsRx.net) -- A newly approved rapid HIV-1 test is really rapid, According to a study from the United States, "The Food and Drug Administration recently approved the OraQuick Rapid HIV-1 Antibody Test. Four...

Nelfinavir downregulates LDL receptors involved in lipoprotein catabolism.
December 8, 2003... 2003 DEC 8 - (NewsRx.com & NewsRx.net) -- The HIV protease inhibitor nelfinavir downregulates LDL receptors involved in lipoprotein catabolism. "Inhibitors of the human immunodeficiency virus (HIV)-1 protease have proven to be effective...

Novel recombinant subtype C HIV-1 strain found in Thailand.
December 8, 2003... 2003 DEC 8 - (NewsRx.com & NewsRx.net) -- A novel recombinant subtype C HIV strain has been isolated in Thailand. Researchers there described "the first HIV-1 recombinant between CRF0I_A.E and subtype C," dubbed NP1809, found in that area....

Small interfering RNAs can silence env in HIV-infected cells.
December 8, 2003... 2003 DEC 8 - (NewsRx.com & NewsRx.net) -- RNA interference (RNAi) can be used to silence expression of the HIV env gene by infected cells. According to scientists in Japan, RNAi "is triggered by the presence of a double-stranded RNA...

Oligodendrocyte Nef expression may underlie HIV-induced vacuolar myelopathy.
December 8, 2003... 2003 DEC 8 - (NewsRx.com & NewsRx.net) -- Expression of the HIV Nef protein by oligodendrocytes may underlie virus-induced vacuolar myelopathy (VM). According to virologists in Canada, VM "is a frequent central nervous system complication...

Anti-Hsp70 antibody levels rise after HIV infection.
December 8, 2003... 2003 DEC 8 - (NewsRx.com & NewsRx.net) -- HIV infection triggers a significant rise in levels of anti-Hsp70 antibodies. "Heat shock proteins (Hsp), especially 70 kDa heat shock protein (Hsp70) play an important role in the life cycle of...

Cyclophilin A needed for functional expression of HIV Vpr.
December 8, 2003... 2003 DEC 8 - (NewsRx.com & NewsRx.net) -- Cyclophilin A is needed for the functional expression of HIV viral protein R (Vpr) by infected cells. According to recent research from Germany, HIV Vpr "is the major virion-associated accessory...

Intrinsic and extrinsic apoptosis pathways both involved in SIV-induced T-cell loss.
December 8, 2003... 2003 DEC 8 - (NewsRx.com & NewsRx.net) -- Caspase-dependent and -independent apoptosis pathways are both involved in SIV-induced T-cell loss. "Studies of human immunodeficiency virus (HIV) and nonhuman primate models of pathogenic and...

Solution structure of mature HIV protease monomer characterized.
December 8, 2003... 2003 DEC 8 - (NewsRx.com & NewsRx.net) -- The structure of mature HIV protease monomer in solution has been characterized. In a recent study, scientists in the United States achieved "the first solution structure of the HIV-1 protease...

Human Nup98 aids HIV Rev-mediated RNA export.
December 8, 2003... 2003 DEC 8 - (NewsRx.com & NewsRx.net) -- HIV RNA export mediated by the viral Rev protein is aided and abetted by a human nucleoporin during infection. According to recent research from the United States, HIV-1 Rev-mediated "nuclear...

Careful cervical monitoring needed for women failing HIV treatment.
December 8, 2003... 2003 DEC 8 - (NewsRx.com & NewsRx.net) -- Careful monitoring of cervical lesions is needed for women failing HIV treatment. In a recent study, scientists in Italy "evaluated the effect of long-term highly active antiretroviral therapy...

Early SHIV control in monkeys causes long-lasting asymptomatic outcomes.
December 8, 2003... 2003 DEC 8 - (NewsRx.com & NewsRx.net) -- Early control of highly pathogenic simian immunodeficiency virus/human immunodeficiency virus (SHIV) chimeric virus infections in rhesus monkeys usually results in long-lasting asymptomatic clinical...

Efavirenz and nevirapine have comparable value as PI replacements.
December 8, 2003... 2003 DEC 8 - (NewsRx.com & NewsRx.net) -- Efavirenz (EFV) and nevirapine (NVP) have comparable value as PI replacements for HIV patients undergoing antiretroviral therapy. In a recent study from Spain, "The outcome of 162 patients...

Hyperlactatemia common during antiretroviral therapy.
December 8, 2003... 2003 DEC 8 - (NewsRx.com & NewsRx.net) -- Hyperlactatemia is common in HIV patients undergoing antiretroviral therapy. According to published research from Italy, "Among 743 HIV-infected patients, a six-month case-control study disclosed a...

Modified WHO therapy effective against chronic diarrhea in HIV patients.
December 8, 2003... 2003 DEC 8 - (NewsRx.com & NewsRx.net) -- A modified World Health Organization (WHO) algorithm is effective for guiding treatment of chronic diarrhea in HIV patients. In a recent study, scientists in Kenya evaluated WHO guidelines "for the...