AIDS Weekly articles from December 1999

AIDS Weekly archives from December 1999

Immune CD8(+) T Cells Prevent Reactivation of T. gondii.(Statistical Data Included)
December 13, 1999... 1999 DEC 13 - (NewsRx.com) Immune CD8(+) T cells can be used to prevent reactivation of Toxoplasma gondii infection in immunosuppressed patients, researchers from the United States suggest. T. gondii infection is a serious cause of...

Hyperthermia Linked to Gene Expression.(Statistical Data Included)
December 13, 1999... 1999 DEC 13 - (NewsRx.com) -- Heat shock proteins induced by hyperthermia may play an important role in the viral regulation of monocytic function by cytomegalovirus. The immediate-early (IE) genes of human cytomegalovirus (CMV) can be...

Periodontal Attachment Loss Associated with MHC Haplotype.(Statistical Data Included)
December 13, 1999... 1999 DEC 13 - (NewsRx.com) -- Peridontal attachment loss in HIV infected patients may be genetically influenced, suggests research from Australia. "Periodontal attachment loss is mediated by overproduction of tumour necrosis factor (TNF)...

Chemokines: Molecular Targets for Therapeutic Intervention.(Statistical Data Included)
December 13, 1999... 1999 DEC 13 - (NewsRx.com) -- Chemokine agonists may help regulate disease, suggest a study from the United States. "Despite the youth of the chemokine field, many antagonists of chemokine function have already been identified and tested at...

Computer Model Assists in Developing HIV-1 RT Inhibitors.(Statistical Data Included)
December 13, 1999... 1999 DEC 13 - (NewsRx.com) -- Quantitative structure-activity relationships (QSAR) and comparative molecular field analysis (CoMFA) models help explain the structural requirements of HIV-1 reverse transcriptase (HIV-1 RT) inhibitory activity of...

Model Could Show How Immune System Is Thwarted by HIV, Cancer.(Statistical Data Included)
December 13, 1999... 1999 DEC 13 - (NewsRx.com) -- Researchers at the Center for Blood Research and Harvard Medical School reported in the November 23, 1999, Proceedings of the National Academy of Sciences the development of an animal model that literally...

Clues to AIDS Virus Variability Discovered.(Statistical Data Included)
December 13, 1999... 1999 DEC 13 - (NewsRx.com) -- Scientists working with monkeys at the University of Wisconsin-Madison have discovered new evidence explaining why retroviruses such as HIV in people and SIV in rhesus monkeys are so variable and difficult for the...

State-Mandated Voluntary Newborn Screening Studied.(Statistical Data Included)
December 13, 1999... 1999 DEC 13 - (NewsRx.com) -- Researchers from the United States recently studied state-mandated voluntary newborn HIV screening in a large university hospital. M. Polaneczky and colleagues, New York Hospital, Cornell Medical Center,...

HIV Plasma Load Not Lowered by TB Treatment in African Study.(Statistical Data Included)
December 13, 1999... 1999 DEC 13 - (NewsRx.com) -- by Salynn Boyles, Senior Editor -- HIV-1 and TNF-alpha plasma load did not decline significantly due to tuberculosis treatment in dually infected patients in Africa. Researchers from the U.S. Centers for...

Secondary Prophylaxis Studied.(Statistical Data Included)
December 13, 1999... 1999 DEC 13 - (NewsRx.com) -- Isoniazid plus sulphadoxine-pyrimethamine is a useful combination for the secondary prophylaxis of patients coinfected with Mycobacterium tuberculosis and HIV. An annual 20 percent excess mortality rate is...

Immunosuppression Linked to T-Cell Function.(Statistical Data Included)
December 13, 1999... 1999 DEC 13 - (NewsRx.com) -- Tuberculosis immunosuppression appears to be related to a primary abnormality in T-cell function, a study from Ohio's Case Western University suggests. Researcher C.S.Hirsch and colleagues evaluated...

Evolutionary Link is Suggested for HIV-1.(Statistical Data Included)
December 13, 1999... 1999 DEC 13 - (NewsRx.com) -- by Salynn Boyles, Senior Editor -- There appears to be an evolutionary link between HIV-1 and a group of endogenous retroviruses first seen some 30 million years ago. Duke University, USA, researchers describe...

HIV Coreceptor CXCR4 Critical for Receptor Internalization.(Statistical Data Included)
December 13, 1999... 1999 DEC 13 - (NewsRx.com) -- CXCR4 serves as the primary coreceptor for entry of T-cell tropic HIV, suggest researchers from the United States. "The G protein-coupled chemokine receptor CXCR4 serves as the primary coreceptor for entry of...

Post-Exposure Therapy May Boost Natural Immunity.(Statistical Data Included)
December 13, 1999... 1999 DEC 13 - (NewsRx.com) -- People who experience flu-like symptoms within several weeks of being exposed to HIV could prevent the disease from progressing by beginning highly active antiretroviral therapies (HAART) immediately. Early...

Treatment May Lead to Disease Manifestations.(Statistical Data Included)
December 13, 1999... 1999 DEC 13 - (NewsRx.com) -- The life-prolonging action of highly aggressive anti-retroviral therapy (HAART) may permit the manifestation of slowly evolving disease, such as neoplasms. F.B. Lillo, of San Raffaele Hospital, Italy, and...

Quantitation with Genotyping Helps Manage Treatment.(Statistical Data Included)
December 13, 1999... 1999 DEC 13 - (NewsRx.com) -- HIV-1 quantitation, combined with genotyping, is helpful in guiding safe, effective antiretroviral treatments for individuals with HIV-1 infection, according to researchers from Argentina. HIV-1 resistance to...

Rapid Mutations Pose Challenge.(Statistical Data Included)
December 13, 1999... 1999 DEC 13 - (NewsRx.com) -- The swift rate of HIV-1 mutations to protease inhibitors poses a challenge to managing antiretroviral treatments with genotyping, according to a report from Argentina. HIV-1 resistance to protease inhibitors is...

Oral Desensitization Is Dose Dependent in AIDS Patients.(Statistical Data Included)
December 13, 1999... 1999 DEC 13 - (NewsRx.com) -- The incidence of new allergic reactions in AIDS patients was lower in patients who were given increasing doses of sulfonamides, as opposed to full doses, according to a report from Brazil. C. Brites and...

HCV a Marker of Risk in HIV Patients.(Statistical Data Included)
December 13, 1999... 1999 DEC 13 - (NewsRx.com) -- HCV is more of a marker of risk than a cofactor responsible for glomerular disease (GN) in patients coinfected with HIV, researchers from Italy report. "The presence of HCV infection in patients with HIV...

Deaths from Liver Disease Increasing in HIV Patients.(Statistical Data Included)
December 13, 1999... 1999 DEC 13 - (NewsRx.com) -- Death from end-stage liver disease has become the leading cause of death in HIV positive patients at one Boston, Massachusetts, hospital. Further, one-third of individuals with HIV and underlying liver disease...

Program Increases Diagnosis, Treatment.(Statistical Data Included)
December 13, 1999... 1999 DEC 13 - (NewsRx.com) -- A program that asks HIV patients to "Bring in a Friend" for testing has significantly increased the number of HIV positive individuals who receive early testing and treatment at an inner-city Los Angeles,...

Tampons Assist in HIV-1 Detection.(Statistical Data Included)
December 13, 1999... 1999 DEC 13 - (NewsRx.com) -- Tampons may help detect HIV-1 in women. J.C. Flichman, of the Hospital de Clinicas Jose de San Martin, Argentina, and associates evaluated specimens obtained from vaginal tampons used by women to determine if...

More Errors Occur with Western Blot HIV-1 Antibody Tests.(Statistical Data Included)
December 13, 1999... 1999 DEC 13 - (NewsRx.com) -- According to the U.S. Centers for Disease Control and Prevention's (CDC) model performance evaluation program, Western blot (WB) HIV-1 antibody testing has a higher error rate than does enzyme immunoassay (EIA)....

33 Million Worldwide AIDS Cases Reported.(Statistical Data Included)
December 13, 1999... 1999 DEC 13 - (NewsRx.com) -- Fueled by an increase in the use of injected drugs, HIV is spreading at an alarming rate, according to a report released November 23, 1999. The United Nations Program on HIV/AIDS and the World Health...

CEL-SCI Announces Data from Phase II Study.(Statistical Data Included)
December 13, 1999... 1999 DEC 13 - (NewsRx.com) -- CEL-SCI Corp., in response to media questions in advance of World AIDS Day, released the following frequently asked questions and answers: Do you have any results from your Phase II HIV vaccine study? The...

U.S. Patent Issued for Novel Fluorescent Protease Assay.(Statistical Data Included)
December 13, 1999... 1999 DEC 13 - (NewsRx.com) -- Aurora Biosciences Corporation announced that the U.S. Patent and Trademark Office (USPTO) has issued U.S. Patent Number 5,981,200 entitled "Tandem Fluorescent Protein Constructs." The patent is one of an extensive...

amfAR Launches Online Version of HIV/AIDS Treatment Directory.(Statistical Data Included)
December 13, 1999... 1999 DEC 13 - (NewsRx.com) -- Health care providers and anyone affected by HIV can now access the latest information on approved and experimental HIV therapies online, The American Foundation for AIDS Research (amfAR) announced. The amfAR...

CDC Urges Caution To Reduce Workplace Needlestick Injuries.(Statistical Data Included)
December 13, 1999... 1999 DEC 13 - (NewsRx.com) -- The U.S. Centers for Disease Control and Prevention (CDC) National Institute of Occupational Safety and Health issued a recommendation on November 23, 1999, that employers adopt strategic measures to protect the 8...

Cutaneous CD8(+) T-Cell Infiltrates Suggest Poor Prognosis.(Brief Article)(Statistical Data Included)
December 27, 1999... 1999 DEC 27 - (NewsRx.com) -- Cutaneous and systemic infiltrates with polyclonal CD8 T lymphocytes are seen in advanced AIDS and are associated with a poor prognosis, suggests research from the United States. "Aggressive non-Hodgkin's...

Macrophages Need Nerve Growth Factor for Survival.(Brief Article)(Statistical Data Included)
December 27, 1999... 1999 DEC 27 - (NewsRx.com) Nerve growth factor (NGF) protects macrophages from the cytopathic effects of HIV infection, reports researchers from Italy. Cells of monocyte/macrophage (M/M) lineage play an important role in the pathogenesis...

Smallpox-Related Virus Exploits Chemokine Receptors.(Brief Article)(Statistical Data Included)
December 27, 1999... 1999 DEC 27 - (NewsRx.com) -- As debate continues on whether to destroy the world's last two vials of smallpox virus, University of California at San Francisco (UCSF) scientists have discovered that a virus related to smallpox uses the same...

CD8 Cells Exposed to CD80 and CD86 Molecules Suppress HIV.(Brief Article)(Statistical Data Included)
December 27, 1999... 1999 DEC 27 - (NewsRx.com) -- Recent findings may provide a possible therapeutic approach to increase CD8(+) cell anti-HIV response, according to researchers in the United States. CD8(+) cells activated in the presence of autologous...

Combination Therapy and Vertical Transmission Studied.(Brief Article)(Statistical Data Included)
December 27, 1999... 1999 DEC 27 - (NewsRx.com) -- Combination antiretroviral therapy in pregnancy reduced viral load and helped to prevent vertical HIV transmission in women with advanced HIV disease, according to a report from the United States. J.P. Mcgowan...

Pokeweed Antiviral Protein Shows Promise.(Brief Article)(Statistical Data Included)
December 27, 1999... 1999 DEC 27 - (NewsRx.com) -- Pokeweed antiviral protein (PAP), a natural product isolated from the pokeweed plant, shows great potential as a new anti-HIV drug, researchers from the Hughes Institute, St. Paul, Minnesota, report. In a...

Sulfated Dextrins Slow Progression of Kaposi's Sarcoma.(Brief Article)(Statistical Data Included)
December 27, 1999... 1999 DEC 27 - (NewsRx.com) -- by Cathy Clark, Senior Editor -- Sulfated dextrins inhibit the formation of new blood vessels, according to researchers from the United Kingdom. They also slow the clinical progression of Kaposi's sarcoma,...

Reduced Fertility Associated with Prior Sub-Fertility.(Brief Article)(Statistical Data Included)
December 27, 1999... 1999 DEC 27 - (NewsRx.com) -- Pre-existing subfertility explains reduced fertility rates in HIV infected women, suggests research from Kenya. "HIV-1 infection is associated with lower fertility among women in sub-Saharan Africa and this...

Gene-Trapping Strategies May Aid Drug Research.(Brief Article)(Statistical Data Included)
December 27, 1999... 1999 DEC 27 - (NewsRx.com) -- Genome-wide gene-trapping strategies may prove to be valuable assays for drug research. "With sequence analysis of the human genome well underway, there is an increasingly urgent challenge to understand the...

Male Circumcision Could Prevent Millions of Infections.(Brief Article)(Statistical Data Included)
December 27, 1999... 1999 DEC 27 - (NewsRx.com) -- A simple, outpatient procedure could potentially save millions of men and their partners from becoming infected with HIV, but health professionals have been reluctant to provide the needed information and...

Key Phase of Human Immune Response Seen.(Brief Article)(Statistical Data Included)
December 27, 1999... 1999 DEC 27 - (NewsRx.com) -- The first detailed pictures of key immune system cells locked onto fragments of a foreign substance provide new clues about how the immune system identifies enemy threats and may even lead to a novel way of...

Sildenafil Metabolism Altered When Given with Indinavir.(Brief Article)(Statistical Data Included)
December 27, 1999... 1999 DEC 27 - (NewsRx.com) -- Drug interactions occur when sildenafil is co-administered with indinavir to HIV positive patients, report researchers from England. "The prevalence of erectile dysfunction in HIV infected men is estimated to...

Recombinant Human Growth Hormone Improves Syndrome.(Brief Article)(Statistical Data Included)
December 27, 1999... 1999 DEC 27 - (NewsRx.com) -- Recombinant human growth hormone (rhGH) improves fat redistribution syndrome (FRS), also known as lipodystrophy, in patients with HIV. Researchers from the United States sought to determine the efficacy of...

HIV-1 Exposed Dendritic Cells Show Increased Cytokine Production.(Brief Article)(Statistical Data Included)
December 27, 1999... 1999 DEC 27 - (NewsRx.com) -- HIV-1 infected dendritic cells (DC) may have increased proinflammatory activity which may facilitate infection of neighboring cells, researchers from Sweden reported. "Dendritic cells (DC) are potential first...

U.S. NIH Researchers Report on Engineered Vaccine Research.(Brief Article)(Statistical Data Included)
December 27, 1999... 1999 DEC 27 - (NewsRx.com) -- Researchers from the U.S. National Institutes of Health are exploring efforts to improve engineered vaccines for HIV and hepatitis C virus. J.A. Berzofsky and colleagues report on several approaches to develop...

Company Announces Preliminary Results from Phase I/II Trial.(Brief Article)(Statistical Data Included)
December 27, 1999... 1999 DEC 27 - (NewsRx.com) -- Hollis-Eden Pharmaceuticals, Inc., San Diego, California, reports preliminary results from the first 13 patients treated with HE2000 in a Phase I/II HIV trial in South Africa. In this study, HE2000 administered...

Younger Women Have Higher Incidence.(Brief Article)(Statistical Data Included)
December 27, 1999... 1999 DEC 27 - (NewsRx.com) -- Puerto Rican women aged 15-24 years have higher incidence of Chlamydia than older women. Nelson Colon of the Puerto Rico Health Department, and associates described the epidemiologic profile of women visiting...

Magnetoencephalography Assesses Abnormal Brain Activity.(Brief Article)(Statistical Data Included)
December 27, 1999... 1999 DEC 27 - (NewsRx.com) -- Magnetoencephalography (MEG) can help detect central nervous system (CNS) abnormalities in HIV and AIDS patients. "MEG is a non-invasive method for detecting abnormal spontaneous and evoked neuromagnetic...

Pilot Study in Colombia Focuses on Knowledge.(Brief Article)(Statistical Data Included)
December 27, 1999... 1999 DEC 27 - (NewsRx.com) -- Behavioral interventions reduce transmission of HIV in low- and high-risk women. R. Garcia and associates evaluated a behavior change intervention in 60 women with stable sex partners (Group A) and 33 female...

Polyoma Virus-Induced Renal Failure in AIDS Patient Reported.(Brief Article)(Statistical Data Included)
December 27, 1999... 1999 DEC 27 - (NewsRx.com) -- Polyoma virus-induced acute renal failure was diagnosed in a patient with AIDS. Polyoma virus-induced renal failure occurs occasionally in renal transplant patients. According to researchers in the United...

Trade Group Releases Information on New Therapies.(Brief Article)(Statistical Data Included)
December 27, 1999... 1999 DEC 27 - (NewsRx.com) -- A new report released December 1, 1999, by the Pharmaceutical Research and Manufacturers of America (PhRMA), Washington, D.C., has found that in addition to the currently available 61 FDA-approved therapies, 102...

Company Ends U.S. Development Program for Adefovir Dipivoxil.(Brief Article)(Statistical Data Included)
December 27, 1999... 1999 DEC 27 - (NewsRx.com) -- Gilead Sciences, Foster City, California, announced December 3, 1999, the termination of its U.S. HIV development program for the investigational agent adefovir dipivoxil 60 mg. This decision follows a U.S....

Ob-Gyns Recommend Expanded Testing for Diabetes, HIV, HCV.(Brief Article)(Statistical Data Included)
December 27, 1999... 1999 DEC 27 - (NewsRx.com) -- African-American, Hispanic, and Native American women are at higher risk than other ethnic groups for diabetes and their routine medical screening should include a fasting glucose test every three years, says the...

AIDS Action Report Card Delivers "F" for Prevention.(Brief Article)(Statistical Data Included)
December 27, 1999... 1999 DEC 27 - (NewsRx.com) -- AIDS Action issued a World AIDS Day report card on December 1, 1999, on the U.S. government's response to the AIDS epidemic with grades in four areas: an "A-" for research, a "B" for care and treatment, a "C" for...

Group Says Government Has "Short-Changed" CDC's Efforts.(Brief Article)(Statistical Data Included)
December 27, 1999... 1999 DEC 27 - (NewsRx.com) -- According to AIDS Action, for the fourth year in a row, U.S. president Clinton and Congress have tied the hands of the nation's public health forces and threatened the health of a new generation of young people at...