AIDS Weekly articles from August 1991

AIDS Weekly archives from August 1991

AIDS conference moved, new chair announced. (Harvard Aids Institute) (Max Essex; VIII International Conference on AIDS, May 1992) (Information Briefs From Worldwide Sources)
August 26, 1991... Harvard Aids Institute The VIII Annual International Conference on AIDS, originally scheduled to be held in Boston, Massachusetts, in May 1992, will be moved to a site outside the United States, according to the Harvard AIDS Institute,...

Vitamin D, UV light possibly harmful to people with HIV. (Harvard Medical School)(ultraviolet radiation) (Information Briefs From Worldwide Sources)
August 26, 1991... Harvard Medical School Vitamin D and similar compounds "might have adverse effects in individuals infected with HIV," researchers at Tufts and Harvard medical schools suggest (see also Periodical Report, page 16, this issue.) The...

Differential effect of MPL on T cell groups suggests potential for improving immune response in AIDS, cancer. (Ribi ImmunoChem Research Inc.) (monophosphoryl lipid A) (Information Briefs From Worldwide Sources)
August 26, 1991... Ribi ImmunoChem Research Inc. MPL immunostimulant (monophosphoryl lipid A) may have the potential to improve immune responsiveness in AIDS and cancer patients by eliminating the inhibitory effects of certain white blood cells,...

Vimrxyn shipped in preparation for phase I clinical trials. (U.S. National Institutes of Health) (AIDS drug) (Information Briefs From Worldwide Sources)
August 26, 1991... U.S. NIH VIMRx Pharmaceuticals Inc. announced that it has shipped to the U.S. National Institutes of Health (NIH) Repository sufficient quantities of its AIDS drug VIMRxyn for the Phase I clinical trials. These trials will be...

Fluconazole effective as prophylaxis of disseminated fungal infections. (VII International Conference on AIDS) (Information Briefs From Worldwide Sources)
August 26, 1991... VII International Conference on AIDS Fluconazole is effective and well-tolerated as prophylaxis against disseminated candidiasis in HIV -positive patients, according to the results of a clinical study presented at the VII International...

AIDS not independent risk factor for suicide, study indicates. (VII International Conference on AIDS) (Information Briefs From Worldwide Sources)
August 26, 1991... VII International Conference on AIDS A psychological study of long-term survivors of AIDS found that an AIDS diagnosis did not independently increase the risk of suicide. The study results were presented at the VII International...

Factors affecting AIDS survival. (University of California) (Information Briefs From Worldwide Sources)
August 26, 1991... University of California Age, race, whether an individual received AIDS via blood transfusion, and, to lesser extent, sex and sexual orientation all influence survival for AIDS patients, according to two University of California...

Ministry releases AIDS statistics. (Costa Rica) (Information Briefs From Worldwide Sources)
August 26, 1991... Costa Rica In a report released August 11, 1991, the Costa Rican Health Ministry's AIDS department said that of 271 cases diagnosed since 1983, 40 were detected in the first seven months of 1991, and 70 in 1990. Of the total, 87 AIDS...

31st Interscience Conference on Antimicrobial Agents and Chemotherapy sponsored. (American Society for Microbiology) (Information Briefs From Worldwide Sources)
August 26, 1991... American Society for Microbiology For the 31st year, the American Society for Microbiology (ASM) will sponsor the Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), September 29 - October 2, 1991 at the McCormick...

AIDS Food Bank becomes Project Open Hand. (California) (Information Briefs From Worldwide Sources)
August 26, 1991... California In what is being called "good management sense," the AIDS Food Bank has officially become the Project Open Hand Food Bank as operations were transferred over from the San Francisco AIDS Foundation. "With AIDS dollars...

Operating room video wins national award. (Novela Health Education)(Surgery in the Age of AIDS, a video program) (Information Briefs From Worldwide Sources)
August 26, 1991... Novela Health Education Surgery in the Age of AIDS (Prevention of Viral Transmission in the Operating Room), a video program produced by Novela Health Education in cooperation with the University of Washington (UW) Department of...

Distribution agreement reached with INCSTAR. (Cellular Products) (AIDS and HTLV-I retrovial diagnostic and research test kits) (Information Briefs From Worldwide Sources)
August 26, 1991... Cellular Products Cellular Products Inc., a company engaged in the development and marketing of biotechnology products, announced that it has executed a distribution agreement with INCSTAR Corp., Stillwater, Minnesota, whereby INCSTAR...

Third-quarter results reported. (Unimed Inc.) (Information Briefs From Worldwide Sources)
August 26, 1991... Unimed Inc. Unimed Inc. reported total consolidated revenues for the third quarter of fiscal 1991 ended June 30 of $2,458,000, $1,250,000 or 103 percent greater than consolidated revenues of $1,208,000 for the third quarter of fiscal...

Year-to-year profits up 400 percent. (Synthetech Inc.) (Information Briefs From Worldwide Sources)
August 26, 1991... Synthetech Inc. Albany, Oregon-based Synthetech Inc. announced profits of $65,629 or $.01 per share for the quarter ended June 30, 1991, compared to a loss of $76,358 or ($.01) per share last year. Revenues of $463,065 were a 69...

Profitable second-quarter results announced. (Newport-Pharmaceuticals International) (Information Briefs From Worldwide Sources)
August 26, 1991... Newport Pharmaceuticals International Newport Pharmaceuticals International Inc. announced continued positive financial results for its second quarter and six months ended June 30, 1991. The company reported net income of...

Highly potent and selective inhibition of HIV-1 replication by a novel series of 6-substituted acyclouridine derivatives. (Information About Grants and Research Worldwide)
August 26, 1991... Highly Potent and Selective Inhibition of HIV-1 AUTHORS: B. Masanori, S. Shigeta, E.DeClercq, H. Tanaka, T. Miyasaka, M. Ubasawa, K. Umezu and R.T. Walker. Fukushima Medical College, Fukushima, Japan; Rega Institute, K.U. Leuven,...

Novel sulfonic acid polymers as a new class of potent and highly selective anti-HIV-1 agents. (Information About Grants and Research Worldwide)
August 26, 1991... AUTHORS: P. Mohan and M. Baba. University of Illinois at Chicago, Chicago, Illinois; Fukushima Medical College, Fukushima, Japan. According to an abstract submitted by the authors to the VII International Conference on AIDS, held in...

Potent and selective anti-HIV activity of 9-(2-phosphonyl-methoxyethyl) adenine (PMEA) in human macrophages. (Information About Grants and Research Worldwide)
August 26, 1991... AUTHORS: L. Ercoli, C. Perno, J. Balzarini, S. Parisi, G. Milanese, R. Calio and G. Rocchi. II University of Rome, Italy; Rega Institute for Medical Research, Leuven, Belgium. According to an abstract submitted by the authors to the VII...

Oxidative stress: a marker of progression and a therapeutic target in HIV infection. (reactive oxygen series, ROS) (Information About Grants and Research Worldwide)
August 26, 1991... AUTHORS: J.P. Revillard. Lab. Immunol. - INSERM U80 UCBL Hop. E. Herriot, Lyon, France. According to an abstract submitted by the authors to the VII International Conference on AIDS, held in Florence, Italy, June 16-21, 1991: "Oxidative...

HIV-1 specific pyridinone RT inhibitors: preclinical biological characterization of two investigational new drugs. (Information About Grants and Research Worldwide)
August 26, 1991... AUTHORS: M. Goldman, J. O'Brien, T. Ruffing, A. Stern, S. Gaul, W. Saari, J. Wai, J. Hoffman, C. Rooney, J. Quintero, W. Schleif, E. Wmini, and J. Nunberg. Merck Sharp & Dohme Research Laboratories, West Point, Pennsylvania. According to...

Inhibition of HIV replication by HIV-specific CTL. (Information About Grants and Research Worldwide)
August 26, 1991... AUTHORS: S. Koenig, G. Jones, E. Boone, A. Brewah, A. Newell, B. Torbett, D. Mosier, and A. Fauci. MedImmune, Inc., Gaithersburg, Maryland; LIR, NIAID, NIH, Bethesda, Maryland; Medical Biology Institute, La Jolla, California. According to...

Enhancement of human immunodeficiency virus 1 replication in monocytes by 1,25-dihydroxycholecalciferol. (vitamin D)(Proceedings of the National Academy of Sciences, Aug. 1991;88(15):6632-6636) (Reviews and Information From Periodicals and Journals Worldwide)
August 26, 1991... SOURCE: Proceedings of the National Academy of Sciences, August 1991;88(15):6632-6636. The biologically active form of vitamin D - at physiologic levels - increases HIV-1 replication in monocytes as powerfully as any HIV enhancer yet...

Pyridinone derivatives: specific human immunodeficiency virus type 1 reverse transcriptase inhibitors with antiviral activity. (L drugs, L-697,639 and L-697-661)(Proceedings of the National Academy of Sciences, Aug. 1991;88(15):6863-6867) (Reviews and Information From Periodicals and Journals Worldwide)
August 26, 1991... SOURCE: Proceedings of the National Academy of Sciences, August 1991;88(15):6863-6867. The identity of the mysterious "L drugs" - non -nucleoside HIV-1 reverse transcriptase inhibitors already in clinical trials - is finally revealed...

Response to treatment with the leukocyte-derived immunomodulator IMREG-1 in immunocompromised patients with AIDS-related complex. (Annals of Internal Medicine, July 15, 1991;115(2):84-91) (Reviews and Information From Periodicals and Journals Worldwide)
August 26, 1991... SOURCE: Annals of Internal Medicine, July 15, 1991;115(2):84-91. The results of a placebo-controlled clinical trial that was once expected to win FDA approval for the immunomodulator IMREG-1 appear in this issue of the Annals of...

Recommendations for preventing transmission of human immunodeficiency virus and hepatitis B virus to patients during exposure-prone invasive procedures. (Morbidity and Mortality Weekly Report Supplement, Aug. 15, 1991) (Reviews and Information From Periodicals and Journals Worldwide)
August 26, 1991... SOURCE: Morbidity and Mortality Weekly Report Supplement, August 15, 1991. "This document has been developed by the Centers for Disease Control (CDC) to update recommendations for prevention of transmission of human...

Notice to readers: process for identifying exposure-prone invasive procedures. (Morbidity and Mortality Weekly Report, Aug. 15, 1991) (Reviews and Information From Periodicals and Journals Worldwide)
August 26, 1991... SOURCE: Morbidity and Mortality Weekly Report, August 15, 1991. "On July 12, 1991, Centers for Disease Control (CDC) published `Recommendations for Preventing Transmission of Human Immunodeficiency Virus and Hepatitis B Virus to...

Government to change AIDS definition to better gauge epidemic. (U.S. Centers for Disease Control) (Informative Briefs From Worldwide Sources)
August 19, 1991... U.S. CDC The federal government will soon expand its AIDS definition to better reflect the magnitude of the HIV epidemic, American Medical News reports. The U.S. Centers for Disease Control (CDC) will announce that, effective...

Leaked report finds fraud at NCI. (U.S. National Institutes of Health; data on the discovery of HIV) (Informative Briefs From Worldwide Sources)
August 19, 1991... U.S. NIH The draft report of an internal U.S. National Institutes of Health (NIH) investigation finds that data on the discovery of HIV were falsified and fabricated by U.S. researchers, the Chicago Tribune claims. The data in...

Large study confirms value of early therapy with Retrovir. (U.S. National Institute of Allergy and Infectious Diseases) (Informative Briefs From Worldwide Sources)
August 19, 1991... U.S. NIAID A study of more than 2,500 HIV-positive homosexual or bisexual men from four metropolitan areas has reinforced the benefits of Retrovir brand zidovudine and preventive drugs for Pneumocystis carinii pneumonia (PCP) in...

Fluconazole drug of choice for esophageal candidiasis and treatment-resistant oral candidiasis. (The Netherlands) (Informative Briefs From Worldwide Sources)
August 19, 1991... The Netherlands Fluconazole has become the agent of choice for both oral and esophageal candidiasis in patients with AIDS, according to a presentation made at Opportunistic Infections: Pathogenesis and Therapy, a symposium during the...

Azoles appear superior to amphotericin B as maintenance therapy for cryptococcosis. (VII International Conference on AIDS) (Informative Briefs From Worldwide Sources)
August 19, 1991... VII International Conference on AIDS The azole antifungal agents appear to be preferable to amphotericin B as suppressive therapy to prevent recurrence of cryptococcosis, according to a paper presented at the VII International...

Long-term AIDS survivors evidence pragmatic, realistic attitude, study indicates. (VII International Conference on AIDS) (Informative Briefs From Worldwide Sources)
August 19, 1991... VII International Conference on AIDS Long-term survivors of AIDS are characterized by a realistic, yet positive outlook toward their illness, according to the results of a psychological study presented at the VII International...

Workshop on AIDS education for Southeast Asian organizations sponsored. (Indonesia) (Informative Briefs From Worldwide Sources)
August 19, 1991... Indonesia The American Foundation for AIDS Research (AmFAR) will sponsor a four-day workshop in Jakarta, Indonesia, to help community-based organizations (CBOs) in Southeast Asia develop proposals for AIDS education projects, and then...

Nearly $800,000 awarded to 15 education projects. (American Foundation for AIDS Research) (Informative Briefs From Worldwide Sources)
August 19, 1991... American Foundation for AIDS Research The American Foundation for AIDS Research (AmFAR) has awarded $793,784 to 15 highly innovative AIDS education projects across the nation, as part of its continuing effort to bring HIV prevention...

Dentist's refusal to treat person with AIDS found to be discriminatory. (New York; Judge Rosemarie Maldonado) (Informative Briefs From Worldwide Sources)
August 19, 1991... New York In a powerful legal ruling, the Chief Administrative Law Judge of the New York Commission on Human Rights held that a dentist's refusal to provide dental services to a patient with AIDS violated the City Human Rights Law. ...

First North American sale of test to detect HIV-1 and HIV-2 approved. (Canada) (Informative Briefs From Worldwide Sources)
August 19, 1991... Canada Genetic Systems Corporation announced that it has received Canadian approval to sell a test for clinical trial use to detect antibodies to both HIV-1 and HIV-2. The test is the first of its kind to be sold in North America....

Patent allowance and federal grant for new antiviral treatment received. (LIDAK Pharmaceuticals) (Informative Briefs From Worldwide Sources)
August 19, 1991... LIDAK Pharmaceuticals LIDAK Pharmaceuticals announced that it has received a notice of allowance on a U.S. patent covering additional uses of its antiviral and antiinflammatory compound, LIDAKOL. The new patent includes 18 claims...

Agreement with Fujisawa USA Inc. announced. (Vestar) (Informative Briefs From Worldwide Sources)
August 19, 1991... Vestar Vestar Inc. announced August 12, 1991, that they have signed an agreement with Fujisawa USA Inc. dissolving their joint venture and assigning all rights to AmBisome. Under the terms of the agreement all assets of the joint...

Fiscal 1991 financial results announced. (Agouron Pharmaceuticals) (Informative Briefs From Worldwide Sources)
August 19, 1991... Agouron Pharmaceuticals Agouron Pharmaceuticals Inc. reported revenues of $4,795,000 and a net loss of $6,621,000 or $1.42 per share, for its fiscal year ended June 30, 1991. The results for fiscal 1991 compare to a loss of...

Revenues up 111 percent. (The Liposome Company) (Informative Briefs From Worldwide Sources)
August 19, 1991... The Liposome Company The Liposome Company, Inc. reported August 13, 1991, total revenues for the second quarter ended June 30, 1991, were $2,170,000, a 111.1 percent increase over the second quarter of 1990. The net loss for the...

Record quarterly revenues reported. (Epitope) (Informative Briefs From Worldwide Sources)
August 19, 1991... Epitope Epitope Inc. reported August 13, 1991, its second consecutive quarter of record revenues. For the three months ended June 30, 1991, revenues of $1,298,685 and a loss of $1,065,279 (13 cents per share) were announced. These...

Association of arthritis, inflammatory muscle diseases and other rheumatic manifestations with HIV positivity and AIDS. (Information About Grants and Research Worldwide)
August 19, 1991... AUTHORS: PA: PA-91-82. National Institute of Arthritis and Musculoskeletal and Skin Diseases. "The Arthritis and Muscle Biology Programs of the National Institute of Arthritis and Musculoskeletal and Skin Diseases invite research...

The principal neutralization determinant of SIV is different than HIV-1. (Information About Grants and Research Worldwide)
August 19, 1991... AUTHORS: S. Putney, A. Langlois, G. LaRosa, R. Desrosiers, R.H. Meloen, K. Javaherian, et al. Repligen Corp., Cambridge, Massachusetts; Duke University, Durham, North Carolina; NERPRC, Southboro, Massachusetts; CVI, Holland. According...

Immunological parameters associated with protection against challenge with HIV-1 in rgp 160-immunized chimpanzees. (Information About Grants and Research Worldwide)
August 19, 1991... AUTHORS: J.W. Mannhalter, N. Barrett, Z. Kupcu, O. Kistner, H.M. Wolf, K. Huber, G. Eder, F. Dorner, R.C. Gallo, B. Moss, MM. Eibl. Immuno AG, Vienna, Austria; NCI, NIAID, NIH, Bethesda, Maryland. According to an abstract submitted by...

Functional conservation between domains mediating antibody-dependent enhancement of HIV-1, HIV-2 and SIV. (Information About Grants and Research Worldwide)
August 19, 1991... AUTHORS: W. E. Robinson Jr., V.M. Hirsch, L. Horton, W.M. Mitchell, P. Johnson. Dept. of Pathology, Vanderbilt University, Nashville, Tennessee; Dept. of Microbiology, Georgetown University, Rockville, Maryland. According to an...

Genetic variability of molecular SIVagm clones in vivo. (apathogenic Simian Immunodeficiency Virus) (Information About Grants and Research Worldwide)
August 19, 1991... AUTHORS: J. Denner, M. Baier, M. Dittmar, K. Cichutek, S. Norley, R. Kurth. Paul-Ehrlich-Institute, Langen, Germany. According to an abstract submitted by the authors to the VII International Conference on AIDS, held in Florence,...

Analysis of mutations in the HIV-1 envelope glycoprotein that affect fusion and infectivity. (Information About Grants and Research Worldwide)
August 19, 1991... AUTHORS: K.A. Page, S.M. Stearns, D.R. Littman. Dept. of Microbiology, University of California, San Francisco, California. According to an abstract submitted by the authors to the VII International Conference on AIDS, held in...

Genetic relationships among international HIV-1 isolates. (Information About Grants and Research Worldwide)
August 19, 1991... AUTHORS: F.E. McCutchan, B.L.P. Ungar, A.K. Fowler, C.R. Roberts, D.S. Burke. Henry M. Jackson Foundation, Rockville, Maryland; Div. of Tropical Public Health, USUHS, Bethesda, Maryland; SRA Laboratories, Rockville, Maryland; Div. of...

Hyperimmune antisera against synthetic peptides representing the glycoprotein of human immunodeficiency virus type 2 can mediate neutralization and antibody-dependent cytotoxic activity. (Proceedings of the National Academy of Sciences, July 1991;88(14):6082-6086) (Reviews and Information From Periodicals and Journals Worldwide)
August 19, 1991... SOURCE: Proceedings of the National Academy of Sciences, July 1991;88(14):6082-6086. Is the SIV/HIV-2 model relevant for AIDS vaccine research? After finding that the V3 loop of HIV-2 can elicit neutralizing antibodies, a Swedish...

Evidence for non-V3-specific neutralizing antibodies that interfere with GP120/CD4 binding in human immunodeficiency virus 1-infected humans. (Proceedings of the National Academy of Sciences, July 1991;88(14):6171-6175) (Reviews and Information From Periodicals and Journals Worldwide)
August 19, 1991... SOURCE: Proceedings of the National Academy of Sciences, July 1991;88(14):6171-6175. The humoral immune response directed against the gp120 envelope protein of HIV-1 in infected humans includes at least two types of neutralizing...

Synergistic inhibition of human immunodeficiency virus type 1 (HIV-1) replication in vitro by 1-/(2-hydroxyethoxy)methyl~-6-phenylthiothymine (HEPT) and recombinant interferon-alpha. (6-substituted acyclouridine derivative)(Antiviral Research, 1991;15:323-330) (Reviews and Information From Periodicals and Journals Worldwide)
August 19, 1991... SOURCE: Antiviral Research, 1991;15:323-330. The 6-substituted acyclouridine derivative known as HEPT, which inhibits HIV-1 but not HIV-2 reverse transcriptase in vitro, shows in vitro anti-HIV synergism with interferon-alpha...

Passive primate protection, Prevention of HIV-1 IIIB infection in chimpanzees by CD4 immunoadhesin, and Prevention of HIV-2 and SIV SM infection by passive immunization in cynomolgus monkeys. (Nature, Aug. 1, 1991;352(6334):376-377, 343-436, and 436-438) (Reviews and Information From Periodicals and Journals Worldwide)
August 19, 1991... SOURCE: Nature, August 1, 1991;352(6334):376-377, 343 -436, and 436-438. Two separate studies demonstrate passive protection of primates against retrovirus infection: but it remains to be seen whether these findings can be applied to...

Effectiveness in disease and injury prevention assessment of broadcast media airings of AIDS-related public service announcements - United States, 1987-1990. (Morbidity and Mortality Weekly Report, Aug. 8, 1991)
August 19, 1991... SOURCE: Morbidity and Mortality Weekly Report, August 8, 1991. "Television and radio public service announcements (PSAs) are an integral part of acquired immunodeficiency syndrome (AIDS) public information campaigns. This report...

Current trends: acquired immunodeficiency syndrome - Dade County, Florida, 1981-1990. (Morbidity and Mortality Weekly Report, July 25, 1991) (Reviews and Information From periodicals and Journals Worldwide)
August 19, 1991... SOURCE: Morbidity and Mortality Weekly Report, July 25, 1991. "In the United States, the impact of the epidemic of acquired immunodeficiency syndrome (AIDS) has been most substantial in urban areas. In addition, AIDS has...

Human immunodeficiency virus-related lymphomas: a possible association between tumor proliferation, lack of ploidy anomalies, and immune deficiency. (Journal of Clinical Oncology, Aug., 1991;9(8):1334-1340) (Reviews and Information From periodicals and Journals Worldwide)
August 19, 1991... The higher proliferative activity and lower incidence of DNA aneuploidy seen in AIDS-related lymphomas compared to non AIDS-related lymphomas of comparable histologic grade appear to represent differences in disease pathogenesis, according to...

Study says AZT and drugs for pneumonia delay onset of AIDS. (Johns Hopkins School of Public Health) (Informative Briefs From Worldwide Sources)
August 12, 1991... Johns Hopkins School of Public Health Johns Hopkins School of Public Health researchers have shown that early use of zidovudine (AZT) and preventive drugs for an AIDS-related pneumonia called PCP (Pneumocystis carinii pneumonia) are...

DDI advances in approval process. (U.S. Food and Drug Administration Advisory Committee) (dideoxyinosine) (Informative Briefs From Worldwide Sources)
August 12, 1991... U.S. FDA Advisory Committee An independent advisory panel has recommended that dideoxyinosine (ddI) be approved for treatment of AIDS patients not responding to zidovudine (AZT), the journal Nature reports. The U.S. Food and Drug...

Patients with AIDS can tolerate substantial loss of CD4 cells. (U.S. National Cancer Institute) (Informative Briefs From Worldwide Sources)
August 12, 1991... U.S. NCI Patients with AIDS are unlikely to die if immune system cells called CD4 cells remain above a specific level, suggests a new study by scientists from the U.S. National Cancer Institute (NCI) and the Harvard School of Public...

Researchers discover neural receptor for HIV. (University of Pennsylvania) (Informative Briefs From Worldwide Sources)
August 12, 1991... University of Pennsylvania University of Pennsylvania researchers have identified a molecule commonly found on the surface of some nerve and brain cells that appears to be the receptor for HIV in brain, spinal cord and nerve infections....

Vision tests monitor disease progress. (Washington University School of Medicine) (Informative Briefs From Worldwide Sources)
August 12, 1991... Washington University School of Medicine The eyes have been called the window to the soul, but researchers at Washington University School of Medicine in St. Louis, Missouri, are turning to these telling organs to learn more about the...

OPRR report on Zagury collaboration leads to agency censuring. (U.S. National Institutes of Health Office for Protection from research Risks; Daniel Zagury) (Informative Briefs From Worldwide Sources)
August 12, 1991... U.S. NIH The NIH Office for Protection from Research Risks (OPRR) has censured the U.S. National Institutes of Health (NIH) for failing to ensure the safety of human subjects in AIDS immunotherapy trials during collaborations with...

New anti-HIV-1 trial to begin. (Johns Hopkins Medical Institutions) (tat inhibitor) (Information Briefs From Worldwide Sources)
August 12, 1991... Johns Hopkins Medical Institutions The Johns Hopkins division of clinical pharmacology is conducting the only U.S. study of an experimental drug called "tat inhibitor" that attacks a process controlling reproduction of HIV. The...

Video stresses HIV risk to healthcare professionals. (Novela Health Education) (Learning Health Care in the Age of AIDS program) (Information Briefs From Worldwide Sources)
August 12, 1991... Novela Health Education "During my second day as a student learning to draw blood, I managed to stick myself with a needle, and later on found out that the patient was HIV positive." The speaker is a young medical technologist...

Predictions map the future of AIDS. (Institute of Management Sciences) (Information Briefs From Worldwide Sources)
August 12, 1991... Institute of Management Sciences The HIV epidemic is currently growing fastest among intravenous drug users. The rate of infection for a group of high-risk women, many of whom are intravenous drug users or partners to them, may be as...

National Biotechnology award bestowed to Dr. Kary B. Mullis. (California) (research on polymerase chain reaction; National Biotechnology Ventures Award) (Information Briefs From Worldwide Sources)
August 12, 1991... California Dr. Kary B. Mullis, 47, is the recipient of the 1991 National Biotechnology Ventures Award for his discovery of a breakthrough DNA amplification technology known as polymerase chain reaction, it was announced by the award...

Hospitals cited in survey of the country's best. (University of California, San Francisco) (Information Briefs From Worldwide Sources)
August 12, 1991... University of California, San Francisco The University of California at San Francisco (UCSF) Medical Center again has been named one of the country's 10 best hospitals in a new survey of leading physicians conducted by U.S. News & World...

Poll finds majority of Americans support animal research. (Foundation for Biomedical Research) (Information Briefs From Worldwide Sources)
August 12, 1991... Foundation for Biomedical Research The majority of the American public support the use of animals for biomedical research and testing, according to a recent poll conducted for the Foundation for Biomedical Research by Research...

At-home treatment now available for genital warts. (Oclassen Pharmaceuticals) (Condylox) (Information Briefs From Worldwide Sources)
August 12, 1991... Oclassen Pharmaceuticals In the middle of summer, the season with the highest incidence of sexually transmitted diseases (STDs), a new prescription drug is now available which will allow people to treat themselves at home for external...

Marketing agreement signed with Du Pont covering AIDS research reagent. (Progenics Pharmaceuticals Inc.) (CD4) (Information Briefs From Worldwide Sources)
August 12, 1991... Progenics Pharmaceuticals Inc. Progenics Pharmaceuticals Inc. announced that it has signed a marketing and distribution agreement with E.I. du Pont de Nemours & Company. The agreement covers soluble CD4, a genetically engineered...

Montagnier joins scientific advisory board. (Calypte Biomedical Corporation) (Luc Montagnier of Institut Pasteur, Paris) (Information Briefs From Worldwide Sources)
August 12, 1991... Calypte Biomedical Corporation Calypte Biomedical Corporation announced that Professor Luc Montagnier of Institut Pasteur, Paris, has joined its Scientific Advisory Board. Montagnier, who discovered HIV in 1983, is an acknowledged...

Initial public offering announced. (Vertex Pharmaceuticals Inc.) (Information Briefs From Worldwide Sources)
August 12, 1991... Vertex Pharmaceuticals Inc. Vertex Pharmaceuticals Inc. announced its initial public offering of 3 million shares of common stock at $9 per share. The net proceeds from the offering will be used to fund research and product development...

Second-quarter results reported. (ImmuLogic Pharmaceutical Corporation) (Information Briefs From Worldwide Sources)
August 12, 1991... ImmuLogic Pharmaceutical Corporation ImmuLogic Pharmaceutical Corporation reported financial results for the second quarter and first half ended June 30, 1991. Revenues for the second quarter were $765,000, compared to $785,000...

Recombinant human CD4 immunoglobulin (rCD4-IgG) in patients with HIV-1 infection. (Information About Grants and Research Worldwide)
August 12, 1991... AUTHORS: R.T. Davey, Jr., V. Davey, J. Metcalf, J. Zurlo, M. Polis, J. Falloon, J. Kovacs, K. Zunich, A. Ammann, H. Masur, A. Fauci and H.C. Lane. National Institute of Allergy and Infectious Diseases and Clinical Center, U.S. National...

Zidovudine-associated alterations in nutrient status impact upon immune function. (VII International Conference on AIDS, France) (Information About Grants and Research Worldwide)
August 12, 1991... AUTHORS: G. Shor-Posner, E. Mantaro-Atienza, R. Beach, J.J. Javier, A. Basit, C. Cabrejos, H.E. Sauberlich, D. Feaster and M.K. Baum. Biopsychosocial Center for Studies of AIDS, University of Miami School of Medicine, Miami, Florida. ...

Immunomodulating effects of nutrient therapy used in combination with AZT. (VII International Conference on AIDS, Florence, Italy)(Information About Grants and Research Worldwide)
August 12, 1991... AUTHORS: J. Priestley, M.D. Search Alliance Community Research Initiative, Los Angeles, California. According to an abstract submitted by the author to the VII International Conference on AIDS, held in Florence, Italy: "Objective:...

Quality of life of patients (CDC IV) in a trial of zidovudine versus zidovudine and interferon-alpha; 24 weeks follow-up. (HIV infected patients) (VII International Conference on AIDS, Florence, Italy)(Information About Grants and Research Worldwide)
August 12, 1991... AUTHORS: J. De Boer, M. Sprangers, J. Frissen, J. Lange, M. van der Ende, G. Schreij, R. Kaufmann, H. Weigel, C. Tan Napel, P. Koopmans and F. van Dam. WHO Collaborating Center on Quality of Life, Amsterdam, The Netherlands; Dutch AIDS...

A phase I study to evaluate the tolerance and safety of GLQ223 in HIV positive individuals. (VII International Conference on AIDS, Florence, Italy)(Information About Grants and Research Worldwide)
August 12, 1991... AUTHORS: J. Ciesielka, M. Jacobs, T. Chew and R. Williams. HIVCare, Saint Francis Memorial Hospital, San Francisco, California; Genelabs Inc., Redwood City, California. According to an abstract submitted by the authors to the VII...

Comparative clinical trial of ribavirin and zidovudine in HIV-infected pediatric patients. Mexican experience. (VII International Conference on AIDS, Florence, Italy)(Information About Grants and Research Worldwide)
August 12, 1991... AUTHORS: M. Gorbea, G. Perez, J. Paquentin, F. Torres, E. Morales and V. Fortu*o. Hospital "La Raza," Infectology Medical Center, IMSS, Mexico City. According to an abstract submitted by the authors to the VII International...

Combination zidovudine and interferon-alpha therapy for patients remaining persistently HIV P24 antigen-positive following zidovudine monotherapy. (VII International Conference on AIDS, Florence, Italy)(Information About Grants and Research Worldwide)
August 12, 1991... AUTHORS: W.M. Reitor, P.J. Cimoch, G. Friedberg, D. Vorce and J. Jackowski. Center for Special Immunology, Fort Lauderdale, Florida. According to an abstract submitted by the authors to the VII International Conference on AIDS, held...

Long-term zidovudine treatment: four-year results of the multicenter Canadian azidothymidine study. (VII International Conference on AIDS, Florence, Italy)(Information About Grants and Research Worldwide)
August 12, 1991... AUTHORS: J. Ruedy, J.S.G. Montaner, C. Tsoukas, J. Falutz, M. Fanning, J. Singer, M.T. Schechter, M. Wainberg and M. O'Shaughnessy. Multicenter Canadian Azidothymidine Trial (MCAT), Canadian HIV Trials Network; Federal Center for AIDS,...

HIV in pregnant women and their offspring: evidence for late transmission. (Lancet, July 27, 1991;338(8761):203-207) (Reviews and Information From Periodicals and Journals Worldwide)
August 12, 1991... SOURCE: The Lancet, July 27, 1991;338(8761):203-207. Vertical transmission of HIV appears to occur near to or at the time of delivery, Swedish researchers suggest. Huddinge University Hospital researcher A. Ehrnst and colleagues...

A phase I/II trial of zidovudine, interferon-alpha, and granulocyte-macrophage colony stimulating factor in the treatment of human immunodeficiency virus type 1 infection. (Journal of Infectious Diseases, July 1991;164(1):43-52) (Reviews and Information From Periodicals and Journals Worldwide)
August 12, 1991... SOURCE: The Journal of Infectious Diseases, July 1991;164(1):43-52. Low-dose GM-CSF ameliorates neutropenia caused by AZT/IFN-alpha combination therapy without reducing antiviral efficacy, but the toxicities associated with this...

Copper inhibits the protease from human immunodeficiency virus 1 by both cysteine-dependent nd cysteine-independent mechanisms. (Proceedings of the National Academy of Sciences, July 1991;88(13):5552-5556) (Reviews and Information From Periodicals and Journals Worldwide)
August 12, 1991... SOURCE: Proceedings of the National Academy of Sciences, July 1991;88(13):5552-5556. The finding that the HIV-1 protease contains copper binding sites suggests new strategies for the development of HIV protease inhibitors, NIH...

Generation of a chimeric human and Simian immunodeficiency virus infectious to monkey peripheral blood mononuclear cells. (Journal of Virology, July 1991;65(7):3514-3520) (Reviews and Information From Periodicals and Journals Worldwide)
August 12, 1991... SOURCE: Journal of Virology, July 1991;65(7):3514-3520. A genetically engineered HIV-1/SIV chimeric clone can infect cultures of peripheral blood mononuclear cells (PBMC) from macaque monkeys, Japanese researchers report. The...