AIDS Weekly articles from April 1995

AIDS Weekly archives from April 1995

FDA set to evaluate new vaccine technology.
April 10, 1995... The U.S. Food and Drug Administration (FDA) is prepared to evaluate new preventive and therapeutic vaccines based on emerging technologies, according to Karen Goldenthal, director of vaccines and related product applications for the FDA's Center...

Naked DNA vaccine protects 1 of 4 monkeys against SHIV. (simian human immunodeficiency virus)
April 10, 1995... A naked DNA HIV vaccine protected one of four monkeys against massive challenge with an infectious HIV/SIV hybrid virus. The vaccine is being developed by a research team led by David B. Weiner of the University of Pennsylvania in collaboration...

New technology permits gene therapy in non-dividing cells.
April 10, 1995... A new synthetic, self-replicating plasmid can express genetic material in the cytoplasm of virtually any type of cell, according to a report at the Third Annual Vaccines: New Technologies and Applications Conference, held March 20-22 in...

Seven cases of HIV spread through insemination reported.
April 10, 1995... At least seven women in California, Arizona and British Columbia have been infected with HIV through artificial insemination received before 1986, according to a recent report. The report concludes that infection with HIV through donor...

Study shows effective treatment for AIDS-induced anorexia.
April 10, 1995... A study of 139 patients at 18 AIDS treatment centers across the United States concluded that dronabinol (Marinol) is a safe and effective treatment for AIDS-induced anorexia associated with weight loss. The patients treated with dronabinol...

Liver biopsy useful in determining infection.
April 10, 1995... Liver biopsy is a powerful tool for the rapid diagnosis of infection in HIV-infected patients who have unexplained fever and abnormal liver function test results, according to a report from France's Institut Pasteur. Hepatobiliary diseases...

HIV-1 RNA isolated in feces using simple method.
April 10, 1995... There may be a link between the route of HIV-1 transmission and the presence of HIV-1 in the intestinal lumen and between the onset of gastrointestinal symptoms and the detection of HIV-1 RNA in feces, according to a report from the Netherlands....

Polio vaccine theory prompts new HIV study by FDA.
April 10, 1995... A Bethlehem, New Hampshire, lawyer has persuaded the U.S. Food and Drug Administration (FDA) to test old polio vaccines for contamination that he thinks might be the link for how HIV spread from monkeys to the human population. Walter Kyle,...

FDA licenses immune thrombocytopenic purpura treatment.
April 10, 1995... Univax Biologics, Inc., Rockville, Maryland, announced that the U.S. Food and Drug Administration (FDA) has licensed Rh Pharmaceuticals Inc., Winnipeg, Canada, to manufacture WinRho SD (Rho (D) Immune Globulin Intravenous (Human)) for the...

R-HGH(M) trial for children with HIV-associated FTT announced. (failure to thrive)
April 10, 1995... A dose-finding study utilizing Serono Laboratories', Norwell, Massachusetts, mammalian cell-derived recombinant human growth hormone (r-hGH(m)), Serostim, in children with HIV-associated "failure to thrive" will begin immediately. Failure to...

Beijing plans new AIDS hot line.
April 10, 1995... China's capital, Beijing, will open a second AIDS hot line to cope with increasing numbers of Chinese wanting information on the fatal disease, the official media said. The hot line, sponsored by Beijing's municipal authorities, will start...

German fund created for patients of tainted blood scandal.
April 10, 1995... The government, pharmaceutical companies and blood centers have created a $175 million fund for 1,300 Germans infected with HIV from tainted blood products, officials said. But a group representing hemophiliacs called the fund inadequate and...

Alaskan senate approves bill to make it a crime to transmit HIV.
April 10, 1995... A bill to create a new felony crime of knowingly transmitting HIV passed the Alaskan State Senate, despite criticism that it might deter voluntary testing for the virus. The charge would apply to people who knew they were infected with HIV and...

Hemophiliacs get extension to sue over HIV.
April 10, 1995... Hemophiliacs who became infected with HIV as a result of using blood products would get additional time to sue for damages under a bill approved by an Assembly committee. The measure approved gives hemophiliacs who have run up against the...

Cancer Center for HIV-Related Malignancies opens. (at Roswell Park Cancer Institute)
April 10, 1995... The Center for HIV-Related Malignancies, Buffalo, New York, has been established at Roswell Park Cancer Institute to meet the needs of patients who have cancer as a result of HIV infection. The center affords patients access to unique, cutting...

Study finds 15 percent of TB cases also have AIDS. (tuberculosis)
April 10, 1995... More than 15 percent of Chicago, Illinois, patients diagnosed with tuberculosis (TB) also have AIDS, attesting to the dramatic resurgence of the lung disease and its growing hold on those stricken with AIDS, according to a new study. The rate...

Five-year-old boy no longer has HIV.
April 10, 1995... A Los Angeles, California, boy who was infected with HIV at birth apparently fought off the infection and is virus-free at age five. Dr. Yvonne J. Bryson, a pediatrician and AIDS specialist at the University of California, Los Angeles (UCLA),...

Stronger guidelines for PCP prophylaxis announced. (Pneumocystis carinii pneumonia)
April 10, 1995... The incidence of Pneumocystis carinii pneumonia (PCP) among HIV-infected infants has not declined in the United States, prompting revision of current guidelines for prophylaxis of these children by the U.S. Centers for Disease Control and...

Three anti-Pneumocystis combined agents effective in ACTG trial. (trimethoprim-sulfamethoxazole and dapsone, AIDS Clinical Trials Group)
April 10, 1995... In severely immunodepressed AIDS patients trimethoprim-sulfamethoxazole and dapsone are more effective than aerosolized pentamidine in preventing Pneumocystis carinii pneumonia, according to a NIAID AIDS Clinical Trials Group (ACTG) study. The...

CDC reports inmate with HIV infects fifty people. (Centers for Disease Control and Prevention)
April 10, 1995... Fifty people who were linked through sex or needles to an HIV infected prisoner also had the virus, and about half didn't know, the government has reported. The case study, published by the U.S. Centers for Disease Control and Prevention...

Dental hygiene student exposed to HIV while treating inmate.
April 10, 1995... A dental hygiene student has tested negative for HIV six weeks after being exposed while treating an infected inmate at the Westville Correctional Center, Indiana, according to a published report. A dental instrument containing body fluids of...

Maternal to fetus PCP reported in France. (Pneumocystis carinii pneumonia)
April 10, 1995... A case of maternal to fetus transmission of Pneumocystis carinii pneumonia (PCP) in France illustrates the importance of prophylaxis against PCP during pregnancy. "To our knowledge, the occurrence of P. carinii pneumonia during pregnancy was...

HHV-6 may alter normal immune functions. (human herpesvirus-6)
April 10, 1995... Normal immune functions may be seriously impaired by the induction of an anergic T-cell state by human herpesvirus-6 (HHV-6), researchers indicated. Louis Flamand, University of Montreal, Montreal, Quebec, Canada, and colleagues performed a...

A one-stage procedure for the measurement of TNF-alpha and IL-6 produced by whole blood from HIV positive individuals. (tumor necrosis factor, interleukin-6)(Research Report)
April 10, 1995... According to an abstract submitted by the authors to the Eighth Mediterranean Symposium on HIV Infection, held March 10-11, 1995, in Toulon, France, "Production of cytokines in vitro may be assessed after stimulation with polyclonal activators....

A study of two procedures of HIV-1 isolation from whole blood culture.(Research Report)
April 10, 1995... According to an abstract submitted by the authors to the Eighth Mediterranean Symposium on HIV Infection, held March 10-11, 1995, in Toulon, France, "Culture techniques for isolation of HIV from small amounts of whole blood treated with...

Pott's disease of the cranio-vertebral junction in an AIDS patient.(Research Report)
April 10, 1995... According to an abstract submitted by the authors to the Eighth Mediterranean Symposium on HIV Infection, held March 10-11, 1995, in Toulon, France, "A case of tuberculosis (TB) of the cervical spine (Pott's disease) associated with a...

Long-term non-progressors among the Italian cohort of hemophiliacs with HIV/AIDS infection.(Research Report)
April 10, 1995... According to an abstract submitted by the authors to the Eighth Mediterranean Symposium on HIV Infection, held March 10-11, 1995, in Toulon, France, "OBJECTIVES: To give an epidemiological characterization of HIV positive, long-term...

Chronic hepatitis band C in HIV positive patients.(Research Report)
April 10, 1995... According to an abstract submitted by the authors to the Eighth Mediterranean Symposium on HIV Infection, held March 10-11, 1995, in Toulon, France, "OBJECTIVES: describe the impact of chronic hepatitis in HIV positive patients (pts) and main...

Transmission of type C hepatitis virus (HC) by intravenous immunoglobulins (IVIG) Gammagard: evaluation of benefit/risk ratio in HIV (HIV+) infected patients.(Research Report)
April 10, 1995... According to an abstract submitted by the authors to the Eighth Mediterranean Symposium on HIV Infection, held March 10-11, 1995, in Toulon, France, "Several cases of HC infection after IVIG Gammagard(R) infusions has been reported. The possible...

HIV antigen immune responses before and after immunotherapy with rp160 in asymptomatic infected individuals.(Research Report)
April 10, 1995... According to an abstract submitted by the authors to the Eighth Mediterranean Symposium on HIV Infection, held March 10-11, 1995, in Toulon, France, "The aim of the investigation was to study HIV immune responses in asymptomatic individuals with...

Rabbits transfused with human immunodeficiency virus type 1-infected blood develop immune deficiency with CD4+ lymphocytopenia in the absence of clear evidence for HIV type 1 infection. (reprinted from AIDS Research and Human Retroviruses, February 1995)(Periodical Report)(Abstract)
April 10, 1995... According to the authors' abstract of an article published in AIDS Research and Human Retroviruses, "Rabbits can be infected with human immunodeficiency virus (HIV-1), but no disease signs similar to acquired immunodeficiency syndrome (AIDS) have...

Carcinoma of the lung in HIV-positive patients: findings on chest radiographs and CT scans. (reprinted from the American Journal of Roentgenology, March 1995)(Periodical Report)(Abstract)
April 10, 1995... According to the authors' abstract of an article published in American Journal of Roentgenology, "OBJECTIVE: Several recent clinical studies have described an association between HIV seropositivity and lung cancer. The purpose of this study was...

Impaired Fc alpha receptor expression is linked to increased immunoglobulin A levels and disease progression in HIV-1-infected patients. (reprinted from AIDS, March 1995)(Periodical Report)(Abstract)
April 10, 1995... According to the authors' abstract of an article published in AIDS, "OBJECTIVES: Expression of immunoglobulin (Ig) A Fc receptors (Fc alpha R) and their saturation by endogenous IgA were studied on blood monocytes and neutrophils to evaluate the...

Effect of adjuvants on immunogenicity of MN recombinant glycoprotein 120 in guinea pigs. (reprinted from AIDS Research and Human Retroviruses, February 1995)(Periodical Report)(Abstract)
April 10, 1995... According to the authors' abstract of an article published in AIDS Research and Human Retroviruses, "The immunogenicity of recombinant gp120 from the MN strain of HIV-1, a candidate HIV-1 vaccine, was evaluated in guinea pigs using adjuvant...

Safety and immunogenicity of a V3 loop synthetic peptide conjugated to purified protein derivative in HIV-seronegative volunteers. (reprinted from AIDS, March 1995)(Periodical Report)(Abstract)
April 10, 1995... According to the authors' abstract of an article published in AIDS, "OBJECTIVES: To develop a peptide-based model for a preventive vaccine for HIV-1 infection. DESIGN: Phase I trial in HIV-1-seronegative volunteers. PARTICIPANTS: Adult...

Preventive chemotherapy for HIV-associated tuberculosis in Uganda: an operational assessment at a voluntary counseling and testing centre. (reprinted from AIDS, March 1995)(Periodical Report)(Abstract)
April 10, 1995... According to the authors' abstract of an article published in AIDS, "OBJECTIVE: To assess the operational aspects of isoniazid preventive chemotherapy (IPT) for tuberculosis in persons dually infected with HIV and Mycobacterium tuberculosis...

Income and AIDS rates in Los Angeles County. (reprinted from AIDS, March 1995)(Periodical Report)(Abstract)
April 10, 1995... According to the authors' abstract of an article published in AIDS, "OBJECTIVE: To examine the relationship between income and AIDS rates in Los Angeles County (LAG) by race/ethnicity. METHODS: 1990 US census data were used to classify LAC...

Protection against HIV may require mucosal immunity.
April 17, 1995... Induction of mucosal immunity may be necessary for vaccine prevention of HIV infection, according to researcher Jiri Mestecky of the University of Alabama at Birmingham. In an invited address to the Second International Conference on...

Efficacy of nonoxynol-9 for HIV prevention debated.
April 17, 1995... Is the contraceptive nonoxynol-9 as effective as condoms in preventing HIV infection? That question was debated in the March issue of AIDS with researchers differing over whether the issue has been settled. K.M. Wittkowski of Germany's...

Autologous blood donation may have limited value.
April 17, 1995... The increased cost of autologous blood donations, coupled with the limited protection of the procedure, may not be justified today, researchers suggested. Despite reports of dangers associated with blood transfusion, significant improvements...

New protease inhibitor trial information.
April 17, 1995... The most current information on clinical trials of the three leading protease inhibitors is detailed in the March 1995 issue of the Journal of the International Association of Physicians in AIDS Care. The journal focuses on the most recent...

Major role seen for IL-12 as vaccine adjuvant. (interleukin 12)
April 17, 1995... The potent cytokine interleukin 12 (IL-12) can be used to modulate both primary and secondary immune responses when used as a vaccine adjuvant, animal studies show. According to Stan F. Wolf of Genetics Institute and Harvard University,...

Gallium-67 identifies TB in HIV. (tuberculosis)
April 17, 1995... Gallium-67 chest scans may be of diagnostic value in the clinical evaluation of HIV-infected patients presenting with fever of unknown origin, according to a report from Spain. Fever is frequent in patients infected with HIV and may be due to a...

M. scrofulaceum in AIDS patient manifests in skin lesions. (Mycobacterium scrofulaceum)
April 17, 1995... University of South Carolina researchers report a case of disseminated Mycobacterium scrofulaceum infection in an AIDS patient presenting as chronic ulcerative and nodular skin lesions with probable cavitary lung involvement. Infection due to...

HIV gains resistance to experimental drugs, study says.
April 17, 1995... The study involved protease inhibitors, a promising group of experimental drugs designed to stop the virus from reproducing by disabling a crucial enzyme. Researchers said the new finding suggests treatment with one protease inhibitor may make...

CW Henderson now largest publisher of health weeklies.
April 17, 1995... Atlanta-based publisher C.W. Henderson has launched both his longest and shortest newsletters. "Based on our number of titles, I believe we are now the world's largest publisher of health weeklies with eleven," he said. AIDS Weekly Plus (50...

Shark cartilage cancer and AIDS study receives FDA grant.
April 17, 1995... The U.S. Food and Drug Administration (FDA) has granted an investigational new drug (IND) application to Lane Labs - USA, Inc., Woodcliff Lake, New Jersey. Under the terms of the application, which was assigned IND 47,373, Lane Labs will...

Expert warns of powerful strains. (of HIV infection)
April 17, 1995... Four strains of HIV usually spread through sexual intercourse between men and women has infected millions in Asia and Africa, and will come to the United States if it hasn't already, a scientist warned. The strains of HIV, known as A, C, D and...

Hydrophobic peptide inhibits cell-cell fusion.
April 17, 1995... Mechanisms of HIV-1 envelope glycoprotein gp120/gp41 interaction with the target cell membrane leading to membrane fusion may be different in cell-cell and virus-cell fusion, according to a report from the University of California at San...

Candidiasis recurrence due to both relapse/reinfection.
April 17, 1995... Recurrences of oropharyngeal candidiasis in AIDS patients can occur both by relapse and reinfection, according to a study from the University of Texas Health Science Center. Oropharyngeal candidiasis caused by Candida albicans is the most...

CD4 count major determinant of death in HIV-related TB. (tuberculosis)
April 17, 1995... Severity of immune deficiency was the major determinant of mortality for HIV-associated tuberculosis patients in a study from Cote d'Ivoire. In earlier studies researcher Alain N. Ackah and colleagues found that HIV-1-infected patients with...

Dapsone/pyrimethamine effective against PCP. (Pneumocystic carinii pneumonia)
April 17, 1995... Dapsone/pyrimethamine appeared to be as effective as aerosolized pentamidine for the prophylaxis of Pneumocystic carinii pneumonia in AIDS patients, and it significantly reduced the incidence of toxoplasmic encephalitis among those who tolerated...

Exclusion of paid donors and p24 antigen testing justified in Thailand.
April 17, 1995... In northern Thailand, the exclusion of paid blood donors as well as the use of p24 antigen testing are justified, researchers from that country and the United States indicated. In order to increase the safety of blood transfusions in Thailand...

Active TB search finds 288 cases in Santa Clara County, California. (tuberculosis)
April 17, 1995... While tuberculosis cases in California dropped by six percent last year, the numbers increased in Santa Clara and Alameda counties, largely due to increased efforts to find and treat people with TB, as well as continued immigration from countries...

Fluconazole active in preventing cryptococcal meningitis.
April 17, 1995... Fluconazole reduces the risk of a first episode of cryptococcal meningitis in HIV-infected patients with CD4 counts less than 250/uL, according to a report from Yale University School of Medicine. Cryptococcal meningitis is the most common...

Toxicity and immunotoxicity studies of a therapeutic anti-HIV plasmid vaccine in rabbits and mice.(Research Report)
April 17, 1995... According to an abstract submitted by the authors to the 34th Annual Meeting of the Society of Toxicology, held March 5-9, 1995, in Baltimore, Maryland, "APL400-001, a plasmid that expresses genes derived from the HIV-1 virus, is a candidate for...

Kaposi's sarcoma among HIV and non HIV infected women.(Research Report)
April 17, 1995... According to an abstract submitted by the authors to the Eighth Mediterranean Symposium on HIV Infection, held March 10-11, 1995, in Toulon, France, "OBJECTIVE: To compare clinical features of Kaposi's sarcoma (KS) in HIV and non HIV infected...

Liver disease caused by hepatitis viruses as an emerging cause of hospital admission and death in HIV+ IDUs. (intravenous drug users)(Research Report)
April 17, 1995... According to an abstract presented by the authors to the 2nd National Conference on Human Retroviruses and Related Infections, held January 29 - February 2, 1995, in Washington, DC, "Actually up to 20% of patients with HIV infection will survive...

Toxicology findings in the use of an oil-in-the water adjuvant, MF59.(Research Report)
April 17, 1995... According to an abstract submitted by the authors to the 34th Annual Meeting of the Society of Toxicology, held March 5-9, 1995, in Baltimore, Maryland, "BIOCINE(R) MF59 Adjuvant is a novel oil in water emulsion composed of squalene (a...

Selective suppression in humoral immunity to treatment with isoniazid in B6C3F1 female mice.(Research Report)
April 17, 1995... According to an abstract submitted by the authors to the 34th Annual Meeting of the Society of Toxicology, held March 5-9, 1995, in Baltimore, Maryland, "Isoniazid (INH) has been widely used as the antibacterial drug for tuberculosis. The...

A vaccine against AIDS: lessons from the past and hopes for the future.(Research Report)
April 17, 1995... According to an abstract submitted by the author to the Eighth Mediterranean Symposium on HIV Infection, held March 10-11, 1995, in Toulon, France, "Safe and effective HIV vaccines are urgently needed to help control the expanding worldwide...

Multibranched peptide constructs derived from the V3 loop of envelope glycoprotein gp120 inhibit human immunodeficiency virus type 1 infection through interactions with CD4.(Research Report)
April 17, 1995... According to an abstract submitted by the authors to the Eighth Mediterranean Symposium on HIV Infection, held March 10-11, 1995, in Toulon, France, "The V3 loop of the gp120 of human immunodeficiency virus type 1 (HIV-1) is assumed to be...

An enzyme immuno assay (EIA) for titration of antibodies to the CD4 binding site of gp120 (CD4BS Abs).(Research Report)
April 17, 1995... According to an abstract presented by the authors to the 2nd National Conference on Human Retroviruses and Related Infections, held January 29 - February 2, 1995, in Washington, DC, "OBJECTIVE: To develop a sensitive, specific and practical assay...

Preparation and characterization of antisense oligonucleotide peptide hybrids containing viral fusion peptides. (reprinted from Bioconjugate Chemistry, January-February 1995)(Periodical Report)(Abstract)
April 17, 1995... According to the authors' abstract of an article published in Bioconjugate Chemistry, "We have developed a strategy for the synthesis of novel oligodeoxynucleotide (ODN)-peptide conjugates on a scale suitable for the investigation of their...

Helper virus-free transfer of human immunodeficiency virus type 1 vectors. (reprinted from the Journal of General Virology, March 1995)(Periodical Report)(Abstract)
April 17, 1995... According to the authors' abstract of an article published in Journal of General Virology, "Recombinant vectors based on the type 1 human immunodeficiency virus (HIV-1) can be used to deliver genes into cells expressing the HIV receptor, CD4. We...

Multiple CTL specificities against autologous HIV-1-infected BLCLs. (B-lymphocyte cell lines)(reprinted from Cellular Immunology, March 1995)(Periodical Report)(Abstract)
April 17, 1995... According to the authors' abstract of an article published in Cellular Immunology, "The cellular immune response to HIV-1 has been well studied but, in many respects, remains incompletely defined. Although CTL specificities against highly...

Infectious disease markers in blood donors in Northern Thailand. (reprinted from Transfusion, March 1995)(Periodical Report)(Abstract)
April 17, 1995... According to the authors' abstract of an article published in Transfusion, "BACKGROUND: A major epidemic of human immunodeficiency virus type 1 (HIV-1) infections that are primarily due to heterosexual transmission has developed in Thailand...

The spectrum of medical conditions and symptoms before acquired immunodeficiency syndrome in homosexual and bisexual men infected with the human immunodeficiency virus. (reprinted from the American Journal of Epidemiology, March 1, 1995)(Periodical Report)(Abstract)
April 17, 1995... According to the authors' abstract of an article published in American Journal of Epidemiology, "The full range and occurrence of medical conditions in persons infected with human immunodeficiency virus (HIV) before they develop illnesses that...

Safety, tolerance, and pharmacokinetics of atevirdine mesylate (U-87201E) in asymptomatic human immunodeficiency virus-infected patients. (reprinted from Antimicrobial Agents and Chemotherapy, March 1995)(Periodical Report)(Abstract)
April 17, 1995... According to the authors' abstract of an article published in Antimicrobial Agents and Chemotherapy, "Atevirdine mesylate (U-87201E) is a new nonnucleoside (bisheteroarylpiperazine) inhibitor of human immunodeficiency virus type 1 reverse...

Fluconazole concentrations in saliva from AIDS patients with oropharyngeal candidiosis refractory to treatment with fluconazole. (reprinted from Antimicrobial Agents and Chemotherapy, March 1995)(Periodical Report)(Abstract)
April 17, 1995... According to the authors' abstract of an article published in Antimicrobial Agents and Chemotherapy, "Fluconazole (FCZ) has been extensively used as a primary therapy for oropharyngeal candidosis in AIDS patients. Clinical resistance to FCZ is...

Successful treatment of Pneumocystis carinii pneumonia in mice with Benanomicin A (ME1451). (reprinted from Antimicrobial Agents and Chemotherapy, March 1995)(Periodical Report)(Abstract)
April 17, 1995... According to the authors' abstract of an article published in Antimicrobial Agents and Chemotherapy, "Benanomicin A (BNM-A) has antimycotic activities via binding to mannan in the cell walls of fungi. Anti-Pneumocystis carinii activity of the...

A new target for anti-HIV strategies.
April 24, 1995... A unique regulatory protein may be the Achilles heel of HIV, a series of new studies suggests. Several separate laboratories are racing to develop novel drugs, vaccines and gene therapies that take advantage of these findings. The new...

In vitro resistance to 3TC shown to be frequent. (2'-deoxy-3'-thiacytidine)
April 24, 1995... In vitro resistance to (-)2'-deoxy-3'-thiacytidine (3TC) developed in a high proportion of HIV-infected individuals who were given prolonged monotherapy with this agent as part of a study conducted through the McGill University AIDS Center....

Several HEPT derivatives active against NNRTI-resistant HIV. (nonnucleoside reverse-transcriptase inhibitors)
April 24, 1995... Three of the compounds known as HEPT derivatives are active against most HIV-1 mutants that have developed resistance to nonnucleoside reverse-transcriptase inhibitors (NNRTIs). NNRTIs are a class of structurally dissimilar drugs that have a...

Single mutation gives HIV resistance to AZT, DDI, DDC, and 3TC. (zidovudine, didanosine, zalcitabine, lamivudine)
April 24, 1995... A single mutation in the HIV-1 reverse transcriptase genome permits the virus to resist zidovudine (AZT), didanosine (ddI), zalcitabine (ddC), and lamivudine (3TC). The mutation - the substitution of lysine for arginine at amino-acid position...

Neonatal macaques useful in evaluating AIDS vaccines.
April 24, 1995... A macaque model of neonatal mucosal infection is an indicator of viral pathogenicity which is useful in evaluating candidate live, attenuated virus vaccines against human AIDS, according to a report from Boston's Harvard Medical School. SIV...

Hypericin profile to potentially include hepatitis C and HIV.
April 24, 1995... VIMRx Pharmaceuticals Inc., Stamford, Connecticut, announced that its program to develop hypericin, its lead antiviral/antiretroviral compound, to inactivate viruses in blood used for transfusions is yielding encouraging data which broaden the...

HIV programs thwarted by policies and cultural barriers.
April 24, 1995... University of California, San Francisco (UCSF), researchers warn that overblown expectations, restrictions to sound health policy-making, and cultural barriers thwart the implementation of effective HIV risk-reduction programs - and urge that...

Study promotes AIDS knowledge and understanding.
April 24, 1995... AIDS education can increase knowledge and understanding of the disease among grade-school children without increasing their fear, a study found. Youngsters who took a special three-week course on AIDS showed increases of two or more years in...

AIDS-related cryptococcosis more frequent in men.
April 24, 1995... AIDS-related cryptococcosis appears to be more frequent among male patients who are HIV-positive than among females, according to a report from an Italian research center. Gender is not often considered as a significant variable affecting the...

Conjunctival squamous cell tumors associated with AIDS.
April 24, 1995... A recent epidemic of conjunctival tumors in Uganda is largely due to HIV infection, according to a recent report. The incidence of conjunctival squamous-cell carcinoma in Kampala, Uganda, was steady at around six per million per year from 1970...

Co- and counter-receptors pivotal in cellular response.
April 24, 1995... There appears to be a pivotal role for adhesion co- and counter-receptors in influencing lymphocyte signalling and cellular response to recall antigens in HIV-1 infected persons, according to a report from the United Kingdom. The results of...

Evidence of HIV oncogenesis in Kaposi's sarcoma - sequential neoplasia.
April 24, 1995... California researchers present evidence of the possible role HIV plays in the oncogenesis of early Kaposi's sarcoma (KS). Michael S. McGrath et al., from the San Francisco General Hospital and the University of California, identified a clonal...

Herpesvirus-like DNA sequence found in endemic African Kaposi's sarcoma.
April 24, 1995... New York researchers report on the finding of DNA of the new human gamma-herpes-like virus in classic, endemic African Kaposi's sarcoma (KS) as well as in AIDS-associated KS. Y.Q. Huang et al. suggest that this herpesvirus may be involved in...