Hepatitis Weekly articles from September 2003

Hepatitis Weekly archives from September 2003

Chromatin antibodies associate with autoimmune hepatitis pathology.
September 1, 2003... 2003 SEP 1 - (NewsRx.com & NewsRx.net) -- Chromatin antibodies associate with autoimmune hepatitis pathology. "Our aims were to determine the frequency and prognostic implications of antibodies to chromatin in autoimmune hepatitis. Three...

Inactivated parapoxvirus ovis protects against hepatitis and herpes viruses.
September 1, 2003... 2003 SEP 1 - (NewsRx.com & NewsRx.net) -- Inactivated parapoxvirus ovis protects against hepatitis and herpes viruses. "It is known that some viruses are able to induce vigorous immune reactions. This study shows that inactivated...

Vancomycin-resistant infections are low among liver transplant candidates.
September 1, 2003... 2003 SEP 1 - (NewsRx.com & NewsRx.net) -- Vancomycin-resistant infections are low among liver transplant candidates. "The orthotopic liver transplant (OLT) population has been particularly affected by the increase in vancomycin-resistant...

SPECT imaging may replace liver biopsies in HIV/HCV coinfected patients.
September 1, 2003... 2003 SEP 1 - (NewsRx.com & NewsRx.net) -- SPECT imaging may offer a non-invasive alternative to liver biopsies in HIV patients with hepatitis C. "Performing a liver biopsy in patients infected with HIV and hepatitis C virus (HCV) is...

Hybrid artificial liver support systems can stem hepatic decline.
September 1, 2003... 2003 SEP 1 - (NewsRx.com & NewsRx.net) -- Hybrid artificial liver support systems can stem hepatic decline. According to recent research from the Peoples Republic of China, "artificial liver support system (ALSS) has been used to treat...

GBV-B infections in marmosets closely resemble human hepatitis C virology.
September 1, 2003... 2003 SEP 1 - (NewsRx.com & NewsRx.net) -- GBV-B infections in marmosets closely resemble human hepatitis C virology. "GBV-B virus is a close relative to hepatitis C virus (HCV) that causes hepatitis in tamarins, and thus, is an attractive...

Several factors contribute to treatment failure in chronic hepatitis C.
September 1, 2003... 2003 SEP 1 - (NewsRx.com & NewsRx.net) -- Several factors contribute to treatment failure in chronic hepatitis C. "The treatment of chronic hepatitis C is currently based on a combination of pegylated interferon (IFN)-alpha and ribavirin....

Thymosin-alpha 1 and interferon combination therapy controls HBV infections.
September 1, 2003... 2003 SEP 1 - (NewsRx.com & NewsRx.net) -- Thymosin-alpha 1 and interferon combination therapy controls HBV infections. "Hepatitis B e antibody (HBeAb) and hepatitis B virus (HBV) DNA positive chronic hepatitis is a clinical entity, distinct...

Antigenic escape shifts the antibody balance in hepatitis C-infected patients.
September 1, 2003... 2003 SEP 1 - (NewsRx.com & NewsRx.net) -- Antigenic escape shifts the antibody balance in hepatitis C-infected patients. "This paper investigates the role of cytotoxic T lymphocyte (CTL) and antibody responses in hepatitis C virus (HCV)...

Hepatitis C virus patients often form elevated serum lipase levels.
September 1, 2003... 2003 SEP 1 - (NewsRx.com & NewsRx.net) -- Hepatitis C virus patients often form elevated serum lipase levels. "Extrahepatic manifestations of chronic hepatitis C virus (HCV) infection have been well described. However, hyperlipasemia and/or...

TNF-alpha -308 genotype does not affect HCV infection risk or treatment efficacy.
September 1, 2003... 2003 SEP 1 - (NewsRx.com & NewsRx.net) -- TNF-alpha -308 genotype does not affect HCV infection risk or treatment efficacy. "A G-to-A polymorphic sequence at position -308 in the tumor necrosis factor alpha promoter (TNF308.2) might be...

Cloned Taiwan-3 HDV isolates can replicate in cell culture.
September 1, 2003... 2003 SEP 1 - (NewsRx.com & NewsRx.net) -- Cloned Taiwan-3 HDV isolates can replicate in cell culture According to published research from Taiwan, "hepatitis delta virus (HDV) genotype II is the predominant genotype in Taiwan and is...

Hepatitis vaccines: Recent advances.
September 1, 2003... 2003 SEP 1 - (NewsRx.com & NewsRx.net) -- According to recent research published in the International Journal for Parasitology, "Despite the availability of hepatitis A vaccines that might provide protection for decades, hepatitis B vaccines...

Herpesvirus 8 infection linked to hepatitis B and HIV infections in Ugandans.
September 1, 2003... 2003 SEP 1 - (NewsRx.com & NewsRx.net) -- Human herpesvirus 8 infection was associated with hepatitis B and HIV infections in Ugandan blood donors. According to recent research from the United States, "Human herpesvirus 8 (HHV-8) is...

Gilead inks nonexclusive HCV licensing agreement, initiate research programs.
September 1, 2003... 2003 SEP 1 - (NewsRx.com & NewsRx.net) -- Gilead Sciences, Inc., (GILD) announced that it has entered into a nonexclusive licensing agreement with Chiron Corp. for the research, development, and commercialization of small molecule therapeutics...

Anemia prevalence is extremely high in renal transplant recipients.
September 1, 2003... 2003 SEP 1 - (NewsRx.com & NewsRx.net) -- Anemia prevalence is extremely high in renal transplant recipients. "The Transplant European Survey on Anemia Management (TRESAM) documented the prevalence and management of anemia in kidney...

Prothrombinase generates thrombosis formation in viral hepatitis infections.
September 1, 2003... 2003 SEP 1 - (NewsRx.com & NewsRx.net) -- Prothrombinase generates thrombosis formation in viral hepatitis infections. According to a study from Canada, "fibrin deposition and thrombosis within the microvasculature is now appreciated to...

Heterologous flaviviruses alter the outcomes of human yellow fever infections.
September 1, 2003... 2003 SEP 1 - (NewsRx.com & NewsRx.net) -- Heterologous flaviviruses alter the outcomes of human yellow fever infections. According to recent research published in the American Journal of Tropical Medicine and Hygiene, "using a recently...

Hepatitis B virus genotypes on India's islands arrived with penal settlers.
September 1, 2003... 2003 SEP 1 - (NewsRx.com & NewsRx.net) -- Hepatitis B virus genotypes on India's islands arrived with penal settlers. "To understand the possible origin of hepatitis B virus (HBV), three of the four hyperendemic, primitive accessible tribes...

Amino acid substitutions on the ISDR associate with hepatitis C viral load.
September 1, 2003... 2003 SEP 1 - (NewsRx.com & NewsRx.net) -- Amino acid substitutions on the ISDR associate with hepatitis C viral load. According to a study from Japan, "the correlation between hepatitis C virus (HCV) genomic sequences and circulating HCV...

The role of anticardiolipin antibodies in chronic viral hepatitis is undefined.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- The role of anticardiolipin antibodies in chronic viral hepatitis is undefined. "Antiphospholipid antibodies are a heterogeneous group of acquired autoantibodies that react with anionic...

Radiofrequency ablation generates 'thermal fixation' of liver cancer.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- Radiofrequency ablation generates 'thermal fixation' of liver cancer. "Radiofrequency ablation (RFA) is increasingly used to treat hepatocellular carcinoma (HCC) in patients awaiting a liver...

Lifestyle modifications improve outcomes for those with alcoholic liver disease.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- Lifestyle modifications improve outcomes for those with alcoholic liver disease. According to a study from the United States, "alcoholic liver disease (ALD) remains a major cause of morbidity and...

Versant HCV RNA 3.0v assay valuable for measuring HCV RNA levels in HIV patients.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- A novel Versant HCV RNA assay is valuable for measuring HCV RNA levels in coinfected HIV patients. In a recent study from Italy, "the new generation assay Versant HCV RNA 3.0v (Bayer Diagnostics)...

Guidelines for screening infants born to HCV-infected mothers are announced.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- Guidelines for screening infants born to HCV-infected mothers have been announced by researchers in Italy. "Hepatitis C virus infection in infancy largely depends on vertical transmission. The...

Stress before liver surgery is milder in donors than in liver disease patients.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- Stress before liver surgery is milder in donors than in liver disease patients. "Partial hepatectomy is a major upper abdominal operation associated with certain stress to the patient. Successful...

Alcohol consumption has serious consequences for hepatitis C patients.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- Chronic alcohol consumption has serious consequences for hepatitis C patients. "The prevalence of hepatitis C is 7-10-fold higher in alcoholics than it is in the general population. Among...

CpG ODN induces IFN-alpha stimulated CD14+ cell killing of tumor cells.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- CpG oligodeoxynucleotide stimulation induces dendritic cell production of IFN-alpha; this allows the CD14+ cells to kill tumor cells by means of TRAIL/Apo-2L-dependent apoptosis. According to a...

FTCD autoantibody production is B-cell driven in autoimmune hepatitis patients.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- FTCD autoantibody production is B-cell driven in autoimmune hepatitis patients. According to published research from Canada, "anti-liver cytosol type 1 (LC1) autoantiloody is detected in 30% of sera...

Interferon inhibits liver cancer dissemination after curative resection.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- Interferon inhibits liver cancer dissemination after curative resection in mice. "The aim of this study was to examine the mechanism of interferon alpha (IFN-alpha) on inhibition of metastasis and...

Hospitals falling short in updating Colorado disease database.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- Colorado hospitals and other health organizations are not regularly updating a state database that tracks diseases such as anthrax, cholera, and the plague, state auditors said on August 18, 2003. ...

American Stock Exchange lists stock of infectious disease drug maker.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- The American Stock Exchange (Amex) listed the common stock of Immtech International, Inc., under the ticker symbol IMM. Immtech International, Inc., is a is a pharmaceutical company focused on the...

HCV-focused biopharma reports 4.3 million net loss for second quarter.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- Genelabs Technologies, Inc., (GNLB) reported revenues of $0.8 million and a net loss of $4.3 million, or $0.07 per share, for the quarter ended June 30, 2003. This compares to revenues of $1.0...

VScan test kits shipped to India, Thailand.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- Medical Services International, Inc., (MSITF) said that, as a result of its recently signed sales agreement with Global Connect Technologies Corporation for India and Thailand, that the VScan rapid test...

Delayed hepatitis A booster still effective in people older than 2 years.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- Delayed hepatitis A booster is still effective in people older than two years. "Current immunization schedules for hepatitis A vaccine specify administration of a booster within 6-12 or 6-18 months...

Two-dose hepatitis B vaccination schedule immunogenic in adults.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- A two-dose schedule of hepatitis B immunization was immunogenic in adults. According to a study from Pakistan and Cuba, "Healthy subjects (15-50 years old) were randomized to receive,...

Hepatitis C upregulation of MHC class I impairs natural killer cell activity.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- Hepatitis C upregulation of MHC class I impairs natural killer cell activity. According to recent research from Germany, "the mechanisms of immune evasion and the role of the early immune response...

Epimmune announces termination of merger agreement.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- Epimmune, Inc., (EPMN) announced that the merger agreement between Epimmune and Anosys has terminated. The companies concluded that conditions did not support the concept of the combined company....

An amino-terminal portion of the HCVNS3 protein has ties to liver cancer risk.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- An amino-terminal portion of the HCVNS3 protein has ties to liver cancer risk. "The NS3 protein of hepatitis C virus subtype 1b (HCV-1b) isolates obtained from 89 patients with hepatocellular...

Alcohol-related metabolizing enzymes affect genes that raise liver cancer risk.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- Alcohol-related metabolizing enzymes affect genes that raise liver cancer risk. "The effect of genetic polymorphisms for glutathione S-transferase (GST) M1, GSTT1, GSTP1-1 (GSTP1), cytochrome P450...

Duck hepatitis B virus core protein contains a central site for genome release.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- Duck hepatitis B virus core protein contains a central site for genome release. "Viral nucleocapsids compartmentalize and protect viral genomes during assembly while they mediate targeted genome...

Chronic hepatitis B therapy flare fails due to hepatitis D coinfection.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- Chronic hepatitis B therapy flare fails due to hepatitis D coinfection. "In 1997, a 27-year-old homosexual man contracted acute hepatitis B that developed into chronic hepatitis. Because of repeated...

New models explain the topology of hepatitis C virus envelope glycoproteins.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- New models explain the topology of hepatitis C virus envelope glycoproteins. According to published research from France, "hepatitis C virus encodes two envelope glycoproteins, E1 and E2, that are...

Hepatitis E virus infection is transmitted from uncooked deer meat to humans.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- Hepatitis E virus infection is transmitted from uncooked deer meat to humans. "Zoonosis has been suggested for hepatitis E virus (HEV) infection, but so far is based only on indirect evidence. We...

Interferon causes sustained hepatitis C virus clearance in kidney recipients.
September 15, 2003... 2003 SEP 15 - (NewsRx.com & NewsRx.net) -- Interferon causes sustained hepatitis C virus clearance in kidney recipients. "To date, there is no available treatment of hepatitis C virus (HCV) infection after renal transplantation (RT). Among...

Serum hepatitis C virus RNA disappears spontaneously in some chronic carriers.
September 15, 2003... 2003 SEP 15 - (NewsRx.com & NewsRx.net) -- Serum hepatitis C virus RNA disappears spontaneously in some chronic carriers. According to recent research from Japan, "the natural course of hepatitis C virus (HCV) infection has not been fully...

Hepatitis B core antigen stimulates interleukin-18 production.
September 15, 2003... 2003 SEP 15 - (NewsRx.com & NewsRx.net) -- Hepatitis B core antigen stimulates interleukin-18 production. "Clearance of hepatitis B virus infection (HBV) infection implies a polyclonal vigorous T-helper 1 (Th1) and cytotoxic T-lymphocyte...

Real-time technologies profile the molecular characteristics of liver cancer.
September 15, 2003... 2003 SEP 15 - (NewsRx.com & NewsRx.net) -- Real-time technologies profile the molecular characteristics of liver cancer. "The aim of this study was to develop and validate a molecular index for the diagnosis of hepatocellular carcinoma...

Hepatitis C status doesn't significantly impact postoperative outcomes.
September 15, 2003... 2003 SEP 15 - (NewsRx.com & NewsRx.net) -- Hepatitis C status doesn't significantly impact postoperative outcomes. According to recent research published in the journal Anesthesia and Analgesia, "the impact of the hepatitis C virus (HCV)...

Hepatitis A virus replication parallels its pathogenesis.
September 15, 2003... 2003 SEP 15 - (NewsRx.com & NewsRx.net) -- Hepatitis A virus replication parallels its pathogenesis. According to recent research published in the Journal of Medical Virology, "the correlation between the length of viremia as detected by...

Hepatitis B virus nucleic acids show patterning with lamivudine treatment.
September 15, 2003... 2003 SEP 15 - (NewsRx.com & NewsRx.net) -- Hepatitis B virus nucleic acids show patterning with lamivudine treatment. "We examined whether lamivudine treatment, in addition to the rapid decline of HBV serum DNA described in a large number...

Vical grants options for cancer targets.
September 15, 2003... 2003 SEP 15 - (NewsRx.com & NewsRx.net) -- Vical, Inc., (VICL) announced that Merck & Co., Inc., (MRK) and Vical have amended their existing license agreement. Under the amended agreement, Merck has obtained an option license for rights to...

Diffusion-weighted MR liver images in hepatitis C patients aren't quantifiable.
September 15, 2003... 2003 SEP 15 - (NewsRx.com & NewsRx.net) -- Diffusion-weighted MR liver images in hepatitis C patients aren't quantifiable. "Magnetic resonance diffusion-weighted imaging (DWI) of the liver was investigated to determine whether this method...

Serial ultrasounds are useful for assessing liver lesions in animal models.
September 15, 2003... 2003 SEP 15 - (NewsRx.com & NewsRx.net) -- Serial ultrasounds are useful for assessing liver lesions in animal models. "The woodchuck hepatitis virus (WHV)/woodchuck system is studied as animal model of human hepatocellular carcinoma (HCC)...

New HIV rapid test is 100% accurate.
September 15, 2003... 2003 SEP 15 - (NewsRx.com & NewsRx.net) -- Medical Services International, Inc., (MSITF) has received test results back from India showing that the VScan rapid test kit for HIV 1&2 was 100% accurate. Based on the results obtained in the...

Carbamyl phosphate synthetase I gene characterized.
September 15, 2003... 2003 SEP 15 - (NewsRx.com & NewsRx.net) -- The features of the carbamyl phosphate synthetase I (CPSI) gene have been characterized. Human CPSI "is an essential hepatic enzyme that initiates the urea cycle," scientists in the United States...

HCV genetic variability does not affect hepatitis treatment response in HIV patients.
September 15, 2003... 2003 SEP 15 - (NewsRx.com & NewsRx.net) -- The genetic diversity of HCV does not affect the response to anti-hepatitis treatment in HIV patients. Researchers in France conducted a study "to examine whether hepatitis C virus (HCV)...

Macrophage inflammatory protein 2 aids regeneration after hepatectomy.
September 15, 2003... 2003 SEP 15 - (NewsRx.com & NewsRx.net) -- Macrophage inflammatory protein 2 promoted liver regeneration after 70% hepatectomy. "Recent studies show CXC chemokine elevations after hepatic resection; blockade of epithelial...

CCR5 genotype does not affect HCV infection risk or treatment outcome.
September 15, 2003... 2003 SEP 15 - (NewsRx.com & NewsRx.net) -- CCR5 genotype does not affect HCV infection risk or treatment outcome. "Unlike in HIV, homozygosity for a 32-bp deletion (Delta32) of the chemokine receptor 5 (CCR5) gene was recently described in...

Early response to therapy allows accurate prediction of treatment success.
September 15, 2003... 2003 SEP 15 - (NewsRx.com & NewsRx.net) -- Early virologic response (EVR) in patients with chronic hepatitis C following 12 weeks of individualized, weight-based dosing of PegIntron (peginterferon alfa-2b) and Rebetol (ribavirin) combination...

Liver cancers develop spontaneously in mice with hereditary fatty liver.
September 15, 2003... 2003 SEP 15 - (NewsRx.com & NewsRx.net) -- Liver cancers develop spontaneously in mice with hereditary fatty liver. According to published research from Japan, "the fatty liver Shionogi (FLS) mouse is an inbred strain that develops...

Thrombosis-related mutation not linked to post-transplant HAT.
September 15, 2003... 2003 SEP 15 - (NewsRx.com & NewsRx.net) -- A thrombosis-related mutation does not appear to increase the risk of hepatic artery thrombosis (HAT) in liver transplant recipients. HAT "after liver transplantation is associated with a high...

The telomerase hTERT gene is a target for oncogenic mechanisms.
September 15, 2003... 2003 SEP 15 - (NewsRx.com & NewsRx.net) -- The telomerase hTERT gene is a target for oncogenic mechanisms. According to published research from the United States, "malignant transformation from mortal, normal cells to immortal, cancer...

Chronic hepatitis B patients with liver cancer may host mutated virus.
September 15, 2003... 2003 SEP 15 - (NewsRx.com & NewsRx.net) -- Chronic hepatitis B patients with liver cancer carry mutated HBV virus. "Chronic hepatitis B infection is a major cause of hepatocellular cancer (HCC). The pathogenesis of the carcinogenesis is...

Hepatitis A virus replication requires nonstructural protein 2B amino acid 216.
September 15, 2003... 2003 SEP 15 - (NewsRx.com & NewsRx.net) -- Hepatitis A virus replication requires nonstructural protein 2B amino acid 216. "Clinical isolates of hepatitis A virus (HAV) replicate inefficiently in cell culture unless mutations are acquired...

Crm1 is involved in hepatitis B virus X protein-induced cancer activation.
September 15, 2003... 2003 SEP 15 - (NewsRx.com & NewsRx.net) -- Crm1 is involved in hepatitis B virus X protein-induced cancer activation. According to a study from the United States, "hepatitis B virus (HBV) includes an X gene (HBx gene) that plays a critical...

The dynamics of hepatitis C virus replication in the liver can be explained.
September 15, 2003... 2003 SEP 15 - (NewsRx.com & NewsRx.net) -- The dynamics of hepatitis C virus replication in the liver can be explained. "Hepatitis C virus (HCV) replication at the cellular level is not fully understood. This study describes an optimized...

TaqMan PCR quantifies viral load during lamivudine therapy for hepatitis B.
September 22, 2003... 2003 SEP 22 - (NewsRx.com & NewsRx.net) -- TaqMan PCR quantifies viral load during lamivudine therapy for hepatitis B. "Monitoring of hepatitis B virus (HBV) levels in serum plays an important role in the management of chronic hepatitis B...

Circulating KL-6 predicts interferon-related interstitial pneumonia.
September 22, 2003... 2003 SEP 22 - (NewsRx.com & NewsRx.net) -- Circulating KL-6 predicts interferon-related interstitial pneumonia. According to a study from Japan, "interstitial pneumonia (IP) is a serious adverse event of interferon alpha (IFNalpha)...

Glycyrrhizin suppositories might improve quality of life in HCV nonresponders.
September 22, 2003... 2003 SEP 22 - (NewsRx.com & NewsRx.net) -- Glycyrrhizin suppositories might improve quality of life in HCV nonresponders. According to recent research from Japan, "intravenous administration of glycyrrhizin has potential efficacy on...

Homogenous HAV particles can be created from laboratory generated intermediates.
September 22, 2003... 2003 SEP 22 - (NewsRx.com & NewsRx.net) -- "Among the picornaviridae, hepatitis A virus (HAV) is unique in that its assembly is driven by domain 2A of P1-2A, the precursor of the structural proteins (Probst, C. et al., J Biol Chem,...

Intracytoplasmic sperm injection circumvents the specter of HCV transmission.
September 22, 2003... 2003 SEP 22 - (NewsRx.com & NewsRx.net) -- Intracytoplasmic sperm injection circumvents the specter of HCV transmission. According to a study from Italy, "an infertile couple with a hepatitis C (HCV) RNA-positive male came to our attention....

Hepatitis B core antibody positivity doesn't rule out liver lobe donation.
September 22, 2003... 2003 SEP 22 - (NewsRx.com & NewsRx.net) -- Hepatitis B core antibody positivity doesn't rule out liver lobe donation. "We studied the safety of right-lobe donor hepatectomy in living donors with a positive serological test result for...

Alanine aminotransferase depicts treatment efforts for chronic hepatitis C.
September 22, 2003... 2003 SEP 22 - (NewsRx.com & NewsRx.net) -- Alanine aminotransferase depicts treatment efforts for chronic hepatitis C. "Studies of the kinetics of hepatitis C virus (HCV) decline during interferon (IFN)-based therapy have led to insights...

Research alliance with 3-Dimensional Pharmaceuticals terminated.
September 22, 2003... 2003 SEP 22 - (NewsRx.com & NewsRx.net) -- BioCryst Pharmaceuticals, Inc., (BCRX) announced that it has terminated its collaboration with 3-Dimensional Pharmaceuticals, Inc., (3DP) to discover and develop inhibitors of certain enzymes of the...

$35M private financing completed by pharmaceutical company.
September 22, 2003... 2003 SEP 22 - (NewsRx.com & NewsRx.net) -- Coley Pharmaceutical Group, Inc., announced that it recently closed on $30 million of a $35 million placement of preferred stock; a $5 million tranche will close within the next month. The funding...

Lumbar spine BMD measurements don't predict post liver transplant fracture risk.
September 22, 2003... 2003 SEP 22 - (NewsRx.com & NewsRx.net) -- Lumbar spine BMD measurements don't predict post liver transplant fracture risk. "Bone disease has emerged as a serious and complex complication after liver transplantation. The purpose of this...

TNP-470 blocks cancer growth mechanisms in rodent models of liver cancer.
September 22, 2003... 2003 SEP 22 - (NewsRx.com & NewsRx.net) -- TNP-470 blocks cancer growth mechanisms in rodent models of liver cancer. "The objective of this study is to determine if treatment with the angiogenesis inhibitor TNP-470 results in impairment of...

Lamivudine has CD4-cell dependent effect on HBV activity.
September 22, 2003... 2003 SEP 22 - (NewsRx.com & NewsRx.net) -- Lamivudine can reduce HBV activity in HIV patients with relatively high CD4 cell counts. In a recent study, scientists in the Netherlands "retrospectively analyzed the effect of lamivudine on...

Hepatitis C virus upregulates interferon type I receptors in blood cells.
September 22, 2003... 2003 SEP 22 - (NewsRx.com & NewsRx.net) -- Hepatitis C virus upregulates interferon type I receptors in blood cells. "To assess whether hepatitis C virus infection (HCV) affects type I interferon (IFN) receptor expression, the expression...

Soluble form of HAV cellular receptor 1 alters HAV conformation.
September 22, 2003... 2003 SEP 22 - (NewsRx.com & NewsRx.net) -- A soluble form of hepatitis A virus (HAV) cellular receptor 1 containing the immunoglobulin- and mucin-like regions is capable of inducing conformational changes in HAV. According to recent...

Additional data submitted for Nabi-HB Intravenous BLA.
September 22, 2003... 2003 SEP 22 - (NewsRx.com & NewsRx.net) -- Nabi Biopharmaceuticals (NABI) announced that it has submitted supplemental data and information to the U.S. Food and Drug Administration (FDA) on its Nabi-HB Intravenous antibody product biologic...

Early response to therapy allows accurate prediction of treatment success.
September 22, 2003... 2003 SEP 22 - (NewsRx.com & NewsRx.net) -- Early virologic response (EVR) in patients with chronic hepatitis C following 12 weeks of individualized, weight-based dosing of PegIntron (peginterferon alfa-2b) and Rebetol (ribavirin) combination...

Viramidine pharmacokinetics have been measured in preclinical studies.
September 22, 2003... 2003 SEP 22 - (NewsRx.com & NewsRx.net) -- Viramidine pharmacokinetics have been measured in preclinical studies. According to recent research published in the journal Antimicrobial Agents and Chemotherapy, "the pharmacokinetics of...