Hepatitis Weekly articles from June 2003

Hepatitis Weekly archives from June 2003

Recurrent hepatitis can remain undetected after liver transplantation.
June 2, 2003... 2003 JUN 2 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - A recent study has shown that patients who undergo liver transplantation for autoimmune hepatitis may have recurrent liver disease that isn't detected in...

Livers rejected for transplantation still yield useful cells for therapy.
June 2, 2003... 2003 JUN 2 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Livers that don't meet the requirements for organ donation can still provide cells that will benefit liver patients. Researchers in Italy reported the new...

Counteracting loops explain immune response to hepatitis C virus infection.
June 2, 2003... 2003 JUN 2 - (NewsRx.com & NewsRx.net) -- Counteracting loops explain immune response to hepatitis C virus infection. According to published research from England, "Cellular immune responses play an important role in the control of...

Regular, light alcohol consumption stems toxin-induced acute hepatitis in rats.
June 2, 2003... 2003 JUN 2 - (NewsRx.com & NewsRx.net) -- Regular light alcohol consumption stems toxin-induced acute hepatitis in rats. "Daily, light ethanol consumption enhances hepatic regeneration following 70% partial hepatectomy in rats. Whether such...

Vinyl chloride monomer exposure compounds the effects of hepatitis B virus.
June 2, 2003... 2003 JUN 2 - (NewsRx.com & NewsRx.net) -- Vinyl chloride monomer exposure compounds the effects of hepatitis B virus. "Vinyl-chloride monomer (VCM), a human carcinogen, has caused angiosarcoma of the liver. Recent studies have shown that...

Hepatitis C virus-related liver cancer can prevail where hepatitis B is endemic.
June 2, 2003... 2003 JUN 2 - (NewsRx.com & NewsRx.net) -- Hepatitis C virus-related liver cancer can prevail where hepatitis B is endemic. According to recent research from Taiwan, "in a community-based prospective study, the authors examined the...

Vascular growth factor predicts recurrence in liver cancer patients.
June 2, 2003... 2003 JUN 2 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - A growth factor that modulates angiogenesis, or neovascularization, is a biomarker for the risk of primary liver cancer recurrence. According to medical...

Interferon and ribavirin prove effective in HCV patients with normal ALT values.
June 2, 2003... 2003 JUN 2 - (NewsRx.com & NewsRx.net) -- Interferon and ribavirin prove effective in HCV patients with normal ALT values. "Combination therapy of interferon-alpha(2b) and ribavirin was prospectively evaluated in 20 patients with chronic...

Hepatitis A vaccine does not affect course of HIV.
June 2, 2003... 2003 JUN 2 - (NewsRx.com & NewsRx.net) -- Hepatitis A vaccination did not affect the course of HIV infection in HIV-positive patients. "The safety and immunogenicity of inactivated hepatitis A (HepA) vaccine was assessed in 133 hepatitis A...

Vaccination against hepatitis A elicits humoral and cellular immune responses.
June 2, 2003... 2003 JUN 2 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - Vaccination against hepatitis A stimulates release of both interferon-gamma and interleukin-10, according to a report in Pharmacotherapy. Mary S....

Data presented on next CoVal fusion in pipeline targeting HBV.
June 2, 2003... 2003 JUN 2 - (NewsRx.com & NewsRx.net) -- Stressgen Biotechnologies Corp. (SSB) presented its latest preclinical research results at the 6th annual Conference on Vaccine Research on its new CoVal fusion compound, HspBcor, designed to treat...

Four hepatitis B prevention programs evaluated.
June 2, 2003... 2003 JUN 2 - (NewsRx.com & NewsRx.net) -- Four hepatitis B prevention programs in four states in the U.S. were evaluated for effectiveness. According to recent research from the United States, "During 1992-2000, the authors studied...

Infection in kidney transplant patient caused by novel mutants of hepatitis B.
June 2, 2003... 2003 JUN 2 - (NewsRx.com & NewsRx.net) -- An infection in a renal transplant recipient caused by novel mutants of hepatitis B virus occurred despite protective anti-hepatitis B surface antibodies. "A renal transplant recipient became...

Viral Hepatitis Prevention Board presents findings on hepatitis B vaccines.
June 2, 2003... 2003 JUN 2 - (NewsRx.com & NewsRx.net) -- The WHO Viral Hepatitis Prevention Board recently presented their findings on hepatitis B vaccines. According to recent research published in the journal Vaccine, "The status and likely impact of...

Antigen-specific T cells and memory cells have alternate roles in HBV activity.
June 2, 2003... 2003 JUN 2 - (NewsRx.com & NewsRx.net) -- Antigen-specific T cells and memory cells have alternate roles in HBV activity. "We analyzed the prevalence and longitudinal fluctuation of hepatitis B virus (HBV)-specific CD8 T cells in chronic...

DNA vaccine and interleukin-12 plasmid protect against hepatitis C.
June 2, 2003... 2003 JUN 2 - (NewsRx.com & NewsRx.net) -- Double boosts of a DNA vaccine along with interleukin-12 protected mice against hepatitis C. "We evaluated the prime-boost immunization consisting of hepatitis C virus (HCV)-core expression plasmid...

RNA aptamers inhibit HCVNS3 protease.
June 2, 2003... 2003 JUN 2 - (NewsRx.com & NewsRx.net) -- RNA aptamers inhibit HCVNS3 protease. "Non-structural protein 3 (NS3) of hepatitis C virus (HCV) has two distinct activities, protease and helicase, which are essential for HCV proliferation. In...

Cloned hepatitis delta virus genotype IIb thrives in cell cultures.
June 2, 2003... 2003 JUN 2 - (NewsRx.com & NewsRx.net) -- Cloned hepatitis delta virus genotype IIb thrives in cell cultures. According to recent research published in the journal Biochemical and Biophysical Research Communications, "analysis of hepatitis...

Enhanced specific gene expression is a new strategy for treating liver cancer.
June 2, 2003... 2003 JUN 2 - (NewsRx.com & NewsRx.net) -- Enhanced specific gene expression is a new strategy for treating liver cancer. "Alpha-fetoprotein (AFP) is a specific tumor marker for hepatocellular carcinoma (HCC). A gene expression system under...

Macrophage inflammatory protein marks a therapy's efficacy against liver cancer.
June 2, 2003... 2003 JUN 2 - (NewsRx.com & NewsRx.net) -- Macrophage inflammatory protein marks a therapy's efficacy against liver cancer. "Macrophage inflammatory protein (MIP-3alpha) is a CC chemokine that attracts immature dendritic cells and...

Interferon-alpha gene transfer improves liver cirrhosis in rodent models.
June 2, 2003... 2003 JUN 2 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Scientists in Japan have reported that interferon-alpha gene therapy prevents liver cirrhosis progression in rodents. The researchers believe the same...

Tanshinone I induces apoptosis in activated hepatic stellate cells.
June 2, 2003... 2003 JUN 2 - (NewsRx.com & NewsRx.net) -- Tanshinone I induces apoptosis in activated hepatic stellate cells. According to a study from South Korea, "hepatic stellate cells play central roles in hepatic fibrosis. The therapeutic goal in...

Percutaneous management of anastomotic biliary stricture is successful.
June 2, 2003... 2003 JUN 2 - (NewsRx.com & NewsRx.net) -- Percutaneous management of anastomotic biliary stricture is successful. According to recent research published in the journal Liver Transplantation, "The purpose of this study was to evaluate the...

Sinusoidal injury may lead to graft damage.
June 2, 2003... 2003 JUN 2 - (NewsRx.com & NewsRx.net) -- Sinusoidal injury may lead to graft damage in liver transplantation. "The aim of this study is to identify the molecular mechanism of small-for-size graft injury through large-scale expression...

HCV infections are detected in many people with primary lymphoma of the liver.
June 2, 2003... 2003 JUN 2 - (NewsRx.com & NewsRx.net) -- HCV infections are detected in many people with primary lymphoma of the liver. "Primary lymphoma of the liver (PLL) is rare. In some cases, the hepatic lymphoma has been diagnosed in patients who...

Neuropsychiatric side effects plague chronic hepatitis C patients on interferon.
June 2, 2003... 2003 JUN 2 - (NewsRx.com & NewsRx.net) -- Neuropsychiatric side effects plague chronic hepatitis C patients on interferon. "The purpose of this study, was to systematically describe the neuropsychiatric side effects of treatment with...

HAV RNA genotype-determining region is not linked to disease severity.
June 2, 2003... 2003 JUN 2 - (NewsRx.com & NewsRx.net) -- HAV RNA genotype-determining region is not linked to disease severity. According to recent research published in the journal Hepatology Research, "although hepatitis A is still a considerable...

Woodchuck hepatitis virus class I polymorphism models aspects of hepatitis B.
June 2, 2003... 2003 JUN 2 - (NewsRx.com & NewsRx.net) -- Woodchuck hepatitis virus class I polymorphism models aspects of hepatitis B. According to recent research published in the journal Tissue Antigens, "the woodchuck (Marmota monax) is an animal model...

Clinical labs could use DNA microarray for detecting hepatitis B virus.
June 2, 2003... 2003 JUN 2 - (NewsRx.com & NewsRx.net) -- Clinical labs could use DNA microarray for detecting hepatitis B virus. "We have developed a sensitive and quantitative assay using a DNA microarray for the detection of hepatitis B virus (HBV) DNA...

Apoptotic signals in hepatitis C virus infection are contradictory.
June 2, 2003... 2003 JUN 2 - (NewsRx.com & NewsRx.net) -- Apoptotic signals in hepatitis C virus infection are contradictory. "Infection with hepatitis C virus (HCV) is characterized by inflammatory liver damage and a long viral persistence associated with...

Hepatitis C virus IRES facilitates protein synthesis in tumor vessels.
June 2, 2003... 2003 JUN 2 - (NewsRx.com & NewsRx.net) -- Hepatitis C virus IRES facilitates protein synthesis in tumor vessels. According to a study from Japan, "the development of gene delivery systems for therapeutic use involves vectors (often...

New cell lines allow scientists to study lamivudine-resistant hepatitis B.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Stable cell lines that express lamivudine-resistant strains of hepatitis B virus (HBV) have been developed by researchers at Glaxo Wellcome-Heritage Research...

IgM antibody provides clues about hepatitis recurrence after liver transplant.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Quantitative monitoring for IgM antibody to hepatitis C virus (HCV) can distinguish viral recurrence from graft rejection in patients who receive liver...

Outcomes for patients with autoimmune liver disease depend on several factors.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- Outcomes for patients with autoimmune liver disease depend on several factors. "Autoimmune hepatitis can affect diverse ethnic groups, and its clinical expression and outcome can vary accordingly....

A decline in alpha-fetoprotein may signal lamivudine-induced stability.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- A decline in alpha-fetoprotein levels may signal lamivudine-induced stability. "Markedly elevated alpha-fetoprotein levels in the range of >1,000 ng/mL are highly suspicious for the presence of...

Triple combination retreatment has limited results in hepatitis C nonresponders.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- Triple combination retreatment has limited results in hepatitis C nonresponders. "Retreatment of interferon-resistant chronic hepatitis C represents a significant clinical challenge. In an...

Serum matrix metalloproteinase is clinically significant in some liver diseases.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- Serum matrix metalloproteinase is clinically significant in some liver diseases. "Matrix metalloproteinases (MMPs) have the ability to degrade basement membranes and may thus play an important role...

Interleukin-1 works through enzymatic pathways to inhibit hepatitis C virus.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- Interleukin-1 works through enzymatic pathways to inhibit hepatitis C virus. "Interleukin-1 (IL-1) plays an important role in the inflammatory process. Some studies have demonstrated that IL-1...

Liposome entrapment of hepatitis A virus peptides produces effective vaccine.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- Liposome entrapment of multiple antigenic peptide bearing VP1 and VP3 domains of the hepatitis A virus is a robust method for vaccine design. "Multiple antigen peptides (MAP) have been demonstrated...

Hepatitis B vaccination of high-risk adults is cost-effective.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- Hepatitis B vaccination of high-risk adults would save lives and money, according to a report in the American Journal of Medicine. According to a study from the United States, "The sequelae of...

Immune transfer through stem cell transplantation effective.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Researchers in Germany have identified a novel method of inducing immunity to hepatitis B virus (HBV) infection. "Previous data indicate that a transfer of...

Researchers find potential new treatment for children.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- Researchers from the Johns Hopkins Children's Center and five other institutions have found that a drug recently approved for adults with chronic hepatitis C (CHC) also may be a safe and effective...

HCV replication occurs on a membranous web in liver cancer cells.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- HCV replication occurs on a membranous web in liver cancer cells. According to a study from Germany, "Formation of a membrane-associated replication complex, composed of viral proteins, replicating...

HDV infection persists without hepatitis B virus envelope protein carbohydrates.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- HDV infection persists without hepatitis B virus envelope protein carbohydrates. "Hepatitis delta virus (HDV) particles are coated with the large (L), middle (M), and small (S) hepatitis B virus...

Genomic imbalances are precursors for hepatocellular carcinoma progression.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- Genomic imbalances are precursors for hepatocellular carcinoma progression. According to recent research from South Korea, "hepatocellular carcinoma (HCC) is one of the most prevalent...

Ketoconazole-induced hepatotoxicity is dose and time dependent in rats.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- Ketoconazole-induced hepatotoxicity is dose and time dependent in rats. According to published research from the United States, "this study has examined ketoconazole (KT)-induced hepatotoxicity in...

Hepatoma hepatitis B virus variants collect in B- and T-cell epitopes of HBx.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- Hepatoma hepatitis B virus variants collect in B- and T-cell epitopes of HBx. "Hepatitis B virus (HBV) X gene, encoding a pleotropic transactivator of HBx protein, has been associated with the...

Observer bias makes grading and staging chronic viral hepatitis problematic.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- Observer bias makes grading and staging chronic viral hepatitis problematic. "We performed a retrospective study to investigate the feasibility of grading and staging of chronic viral hepatitis on...

Hepatitis C virus nonstructural proteins display complex interactions.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- Hepatitis C virus nonstructural proteins display a variety of complex interactions. According to a study from France, "replication of the hepatitis C virus (HCV) genome has been proposed to take...

Hepatitis C drug market to grow to $9 billion in 2012.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- Decision Resources, Inc., one of the world's leading research and advisory firms focusing on pharmaceutical and healthcare issues, finds that the hepatitis C virus (HCV) drug market will grow from $2.5...

Genotype 1a subgenomic hepatitis C virus replicons advance viral analysis.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- "Recently, cell-based replicon systems for hepatitis C virus (HCV), in which the nonstructural proteins stably replicate subgenomic viral RNA in Huh? cells, were developed. To date, one limitation of...

The topology of hepatitis C virus protein NS4B suggests many shared functions.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- The topology of hepatitis C virus protein NS4B suggests many shared functions. According to recent research from Sweden, "hepatitis C virus (HCV) belongs to the Hepacivirus genus in the Flaviviridae...

Other viral infections common among HIV-infected women.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- Other viral infections are common among HIV-infected and high-risk HIV-uninfected women. According to a study from the United States, "Viruses that can persist in the host are of special concern in...

Induction and prolonged maintenance therapy yields results in HCV nonresponders.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Patients diagnosed with chronic hepatitis C who don't respond to typical treatment regimens may fare better with combinations of induction and prolonged...

Shunning steroids reduces HBV reactivation risk for patients with lymphoma.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Omitting steroids from the drug regimens of hepatitis B virus (HBV) carriers with lymphoma is a significant way to prevent viral reactivation. According...

MIA2 expression could be a marker for chronic liver injury.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- MIA2 expression could be a marker for chronic liver injury. "The novel human gene MIA2 encoding a melanoma inhibitory activity (MIA) homologous protein was identified by a GenBank(TM) search....

Nanoparticle-supported gene probes visualize HBV and HCV genotypes.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- Nanoparticle-supported gene probes visualize HBV and HCV genotypes. "A visual gene-detecting technique using nanoparticle-supported gene probes is described. With the aid of gold...

Replicable HBV persists in the blood of patients recovered from acute hepatitis.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- Replicable HBV persists in the blood of patients recovered from acute hepatitis. According to recent research from Japan, "several studies have reported the presence of hepatitis B virus (HBV) DNA...

Adaptation causes hepatitis C diversification after liver transplantation.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- Adaptation causes hepatitis C virus diversification after liver transplantation. According to published research from the United States, "liver transplantation represents a unique model for...

Interferon wipes out hepatitis C virus-associated cryoglobulinemia symptoms.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- Interferon wipes out hepatitis C virus-associated cryoglobulinemia symptoms. "We describe a 54-year-old man with hepatitis C virus (HCV) infection-associated cryo-globulinemia type III. The patient...

Celiac disease should be ruled out in autoimmune liver disease patients.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- Celiac disease should be ruled out in autoimmune liver disease patients who present with unspecific symptoms. "The clinical presentation of adult celiac disease is often uncharacteristic, with...

Cytoskeletal alterations make liver cells vulnerable to self destruction.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- Cytoskeletal alterations make liver cells vulnerable to self destruction. "Immunopathological differences between autoimmune hepatitis (AIH) and chronic hepatitis C (CH-C) have not been well...

An endogenous pathway drives the efficacy of hepatitis C combination therapy.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- An endogenous pathway drives the efficacy of hepatitis C combination therapy. According to a study from England, "the success of interferon-alpha and ribavirin combination therapy for the treatment...

Higher doses of interferon may benefit HCV genotype 1 nonresponders.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- Higher doses of interferon may benefit HCV genotype 1 nonresponders. "A randomized trial was conducted to assess the efficacy of daily (QD) or thrice weekly (TIW) administration of interferon-alpha...

Cambodian herpesvirus-8 and hepatitis B transmission patterns are differential.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- Cambodian herpesvirus-8 and hepatitis B transmission patterns are differential. "Among 164 individuals in a rural population of Cambodia, antibodies to human herpesvirus-8 (HHV-8) were found among...

Interferon receptor gene promoter polymorphisms dictate hepatitis C response.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- Interferon receptor gene promoter polymorphisms dictate hepatitis C response. "We studied a possible correlation between the dinucleotide microsatellite polymorphism of the interferon alpha/beta...

Hepatitis C virus prevents HAART-induced immune deactivation.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- Hepatitis C virus (HCV) prevents immune deactivation in HIV patients treated with antiretroviral agents. The impact of HCV coinfection "on the kinetics of serum beta 2-microglobulin levels in...

Study shows liver complications in chronic hepatitis C associated with obesity.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- Patients with chronic hepatitis C who are overweight or obese, especially in the abdominal area, are at increased risk for having fatty liver (steatosis) and a more serious condition called...

Mimotope-based vaccines may be effective hepatitis C virus immunogens.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- Mimotope-based vaccines may be useful as hepatitis C virus immunogens "The hypervariable region 1 (HVR1) of the E2 protein of hepatitis C virus (HCV) is highly heterogeneous in its primary sequence...

Suicidal gene therapy.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- An international collaboration of scientists has demonstrated the promise of gene therapy for combating hepatitis C infections, which affect about 200 million people worldwide. Currently, the...

Fournier's gangrene accompanies a severe case of alcoholic hepatitis.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- Fournier's gangrene accompanies a severe case of alcoholic hepatitis. "Fulminant necrotizing soft-tissue infection of the external genitalia and perineum (Fournier's gangrene) occurred in a patient...

Myofibroblast-like cells may link T cells to liver fibrosis.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- Myofibroblast-like cells may link T cells to liver fibrosis. According to a study from Japan, "apoptosis of T cells contributes to the immune homeostasis in inflamed organs. A prominent T-cell...

Renal syndrome linked to hepatitis B infection clears with lamivudine therapy.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- Renal syndrome linked to hepatitis B infection clears with lamivudine therapy. "A 6 year old boy presenting with a five month history of fever, lethargy, and anorexia, was found to have hepatitis B...

New company alliance will develop new interferon alpha and beta products.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- Roche and Maxygen, Inc., (NASDAQ:MAXY) have announced a new alliance to collaborate on the global development and commercialization of Maxygen's portfolio of next-generation interferon alpha and...

Contaminated intravenous anesthetic ampoules led to hepatitis C transmissions.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- Contaminated intravenous anesthetic ampoules led to hepatitis C transmissions. "Two separate cases of acute hepatitis C virus (HCV) infection following medical procedures, arthroscopy and...

Interferon-alpha is effective therapy for children with chronic hepatitis C.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- Interferon-alpha is effective therapy for children with chronic hepatitis C. According to published research from Italy, "children with chronic hepatitis C may be ideal candidates for treatment...

Phase I trial of interferon enhancing therapy completed.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- Transition Therapeutics, Inc., announced that it has completed enrollment and dosing for its Phase I human clinical trial of its interferon enhancer (EMZ701). Twenty healthy volunteers were...

The transmembrane domain of HCV E1 protein may promote viral pathogenesis.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- The transmembrane domain of HCV E1 protein may promote viral pathogenesis. According to a study from Italy, "the molecular mechanisms of pathogenesis in hepatitis C virus (HCV) infection are not...

E-cadherin is a marker for the risk of liver cancer recurrence after resection.
June 23, 2003... 2003 JUN 23 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Researchers in Japan have identified a marker that predicts the risk of cancer recurrence following surgery for primary liver cancer. The marker is...

TACE delays liver cancer progression in patients awaiting donated organs.
June 23, 2003... 2003 JUN 23 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Patients awaiting liver transplantations due to hepatocellular carcinoma can benefit from therapy that prevents tumor progression. Hepatocellular...

Adefovir dipivoxil is an important new therapy for treating hepatitis B virus.
June 23, 2003... 2003 JUN 23 - (NewsRx.com & NewsRx.net) -- Adefovir dipivoxil is an important new therapy for treating hepatitis B virus. "In chronic hepatitis B therapy there are new and exciting developments in antivirals such as nucleotide analogues....

NS3/4A is a dual target for the treatment of patients with chronic hepatitis C.
June 23, 2003... 2003 JUN 23 - (NewsRx.com & NewsRx.net) -- NS3/4A is a dual target for the treatment of patients with chronic hepatitis C. "Persistent infections with hepatitis C virus (HCV) are likely to depend on viral inhibition of host defenses. We...

A cell-based assay monitors hepatitis C virus NS3/4A activity in cells.
June 23, 2003... 2003 JUN 23 - (NewsRx.com & NewsRx.net) -- "The hepatitis C virus (HCV) contains a positive-sense RNA genome that encodes a unique polyprotein precursor, which must be processed by proteases to enable viral maturation. Virally encoded NS3/4A...

Autoimmune hepatitis and Graves disease coexist in the same patient.
June 23, 2003... 2003 JUN 23 - (NewsRx.com & NewsRx.net) -- Autoimmune hepatitis and Graves disease can coexist in the same patient. According to recent research from Japan, "a 31-year-old woman with Graves' disease with a 12-month-history of...