Blood Weekly articles from September 2004

Blood Weekly archives from September 2004

Cord blood company initiates lawsuits to protect patent rights.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- PharmaStem Therapeutics, Inc., announced that it has initiated multiple lawsuits for patent infringement to protect its intellectual property rights relating to umbilical cord blood stem cells. ...

U.S. communities to raise money in September for blood cancer research.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- September marks the annual observance of Leukemia, Lymphoma and Myeloma Awareness Month, a time to commemorate the estimated 670,000 patients in the U.S. currently battling blood cancers. As part...

Company introduces enhanced red cell collection technology.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- Haemonetics Corp. introduced an enhancement to its leukocytes-reduced red cell collection technology that, according to the company, triples the time within which donated blood can be filtered to remove...

Anti-idiotypic Ab neutralizes anti-C2 FVIII inhibitor.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- A novel anti-idiotypic Ab neutralizes C2 domain-specific factor VIII (FVIII) inhibitors. FVIII administration "elicits specific inhibitory antibodies (Abs) in about 25% of patients with hemophilia...

Blood donation may be a source of hepatitis E virus transmissions in Japan.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- Blood donation may be a source of hepatitis E virus transmissions in Japan. "Risk factors for acquiring hepatitis E among individuals in industrialized countries including Japan are not fully...

AML-associated mutant inhibits differentiation of myeloid/erythroid stem cells.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- An acute myeloid leukemia-associated mutant inhibits differentiation of myeloid/erythroid stem cells. "The CCAAT/enhancer binding protein alpha (C/EBPalpha) is an essential transcription factor for...

Antibody against VEGF receptor arrests human leukemia cell proliferation.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- Antibody against VEGF receptor arrests human leukemia cell proliferation. "Vascular endothelial growth factor (VEGF) and its receptors (VEGFR) have been implicated in promoting solid tumor growth...

Clopidogrel-associated autoimmune thrombocytopenic purpura reported.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- A case of clopidogrel-associated autoimmune thrombocytopenic purpura has been reported. Physcians in the United States described their experience treating "a 51-year-old male who underwent coronary...

Efavirenz plasma levels reproducibly predictive of primary treatment failure.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- Efavirenz plasma levels are reproducibly predictive of primary treatment failure in HIV-infected patients. According to recent research from Sweden, "Efavirenz is a drug subject to extensive...

Novel benzodithiazines are nontoxic and have anti-HIV-1 integrase activity.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- Novel benzodithiazines are nontoxic and have anti-HIV-1 integrase activity. "HIV-1 integrase (IN) is an essential enzyme for effective viral replication and is an attractive target for selective...

Pancreatitis associated with didanosine plus tenofovirin in HIV infection.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- Pancreatitis is associated with coadministration of didanosine and tenofovirin in HIV infection. "The rise in didanosine concentrations in plasma when given with tenofovir raises concern for a high...

Ritonavir decreases nonrenal clearance of digoxin.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- Ritonavir decreases the nonrenal clearance of digoxin. "Our objective was to examine the influence of ritonavir on P-glycoprotein (P-gp) activity in humans by characterizing the effect of ritonavir...

Sustained benefit of HAART lost when prisoners return to community.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- The sustained benefit of highly active antiretroviral therapy is lost when HIV-1-infected prisoners return to the community. "Responses to highly active antiretroviral therapy (HAART) in...

Levan polysaccharides have strong antitumor activity.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- Levan polysaccharides have strong antitumor activity. According to recent research from South Korea, "Levans were isolated from the cultures of Gluconoacetobacter xylinus (G-levan; M-w=40,000),...

U.S. NIH awards nearly $1.5 million for study of human bone precursor cells.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- Velcura Therapeutics, Inc. was awarded $1,452,000 to study the mechanisms by which primitive cells develop into mature bone-forming cells. Velcura, as part of its work developing therapies for bone...

tetR real-time PCR detects and quantifies tetracycline-resistant bacteria.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- A tetR real-time PCR assay detects and quantifies tetracycline-resistant bacteria. According to recent research published in the Journal of Biochemical and Biophysical Methods, "Bacteria of implant...

Researchers study the dependence of blood flow conductivity on flow velocity.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- Researchers in the Netherlands have extended the Maxwell-Fricke theory to explain the dependence of the electrical conductivity of blood flow on flow velocity. According to a study from the...

Pegylated polystyrene particles serve as a model system for artificial cells.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- Pegylated polystyrene particles serve as a model system for artificial cells. According to published research from the Netherlands, "Pegylated polystyrene particles (PS-PEG) were prepared as a model...

Stem cell gene therapy produces regenerative bone protein in healing mice.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- Stem cell gene therapy produces regenerative bone protein in healing mice. "Muscle-based gene therapy and tissue engineering hold great promise for improving bone healing. However, the relative...

Company reports $8.8M Q2 loss, provides clinical update.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- Emisphere Technologies, Inc., (EMIS) announced results for the second quarter ended June 30, 2004. The company also highlighted its progress in development programs using its proprietary eligen...

Pharmaceutical company licenses compound from Millennium Pharmaceuticals.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- Portola Pharmaceuticals, Inc., announced that it has licensed Millennium Pharmaceuticals, Inc.'s, Factor Xa inhibitor program. Given orally once a day, the lead compound is a small molecule that...

Pittsburgh incubator signs Revivicor, Inc. as new tenant.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- The Pittsburgh Life Sciences Greenhouse (PLSG) announced that Revivicor has leased laboratory space in the PLSG Incubator. Revivicor commercializes therapies that can treat and cure serious human...

Liver-directed cell therapy is expected to augment organ shortages.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- Liver-directed cell therapy is expected to augment organ shortages. According to a study from the United States, "Treatment of acute or chronic liver diseases by cell transplantation is an...

Child with atypical CML treated successfully with imatinib mesylate.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- A child with atypical chronic myelogenous leukemia was treated successfully with imatinib mesylate. "Atypical chronic myelogenous leukemia (aCML) is a myelodysplastic/myeloproliferative disorder...

Biotech company updates phase 3 clinical trial of acute transfusion study.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- V.I. Technologies, Inc. (VITX), a biotechnology company developing anti-infective products, provided an update on the status of the company's acute transfusion phase 3 clinical trial. It also...

Company introduces cloned cats born by new technique.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- The first two cats cloned by chromatin transfer (CT), a new cloning technology, are healthy and normal after having been born June 10 and 12, 2004. Genetic Savings & Clone (GSC), a pet-gene banking...

Rituximab safe and effective as CAD therapy.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- Rituximab is a safe and effective treatment for cold agglutinin disease (CAD). According to recent research from Norway, standard treatments for primary chronic CAD are "ineffective, but remissions...

Interferons effective in the treatment of severe acute respiratory syndrome.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- Interferons are effective in the treatment of severe acute respiratory syndrome. "Severe acute respiratory syndrome (SARS) is caused by the SARS coronavirus (SCV). The disease appeared in the...

SARS-CoV entry suppressed by peptides corresponding to HR on spike glycoprotein.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- SARS-CoV entry is suppressed by peptides corresponding to heptad repeat regions on spike glycoprotein. According to published research from China, "Heptad repeat regions (HR1 and HR2) are highly...

SARS-CoV follows the general fusion mechanism of class I viruses.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- SARS-coronavirus follows the general fusion mechanism of class I viruses. "Severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) is a newly identified member of Family Coronaviridae,"...

New research focuses on developmental and stem cell biology.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- Joslin Diabetes Center has established a new section on Developmental and Stem Cell Biology. Research in this field has been ongoing at Joslin for a number of years, particularly in identifying...

Low viremia accounts for seronegative diagnoses in some hepatitis B carriers.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- Low viremia accounts for seronegative diagnoses in some hepatitis B carriers. According to a study from France, "occult hepatitis B virus (HBV) infections show little or no serological markers of...

Gene expression patterns in leukemia cells linked to treatment outcome.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- A relatively small number of genes are linked to either resistance or sensitivity to four major cancer drugs used to treat acute lymphoblastic leukemia (ALL), suggesting that these genes are key to...

ETS transcription factor GABP alpha essential for early embryogenesis.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- The ETS transcription factor GABP alpha is essential for early embryogenesis. "The ETS transcription factor complex GABP consists of the GABPalpha protein containing an ETS DNA binding domain, and...

pRb and p107 play a central role in regulating epidermal homeostasis.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- pRb and p107 play a central role in regulating epidermal homeostasis. According to published research from the Netherlands, "The retinoblastoma gene product, pRb, plays a crucial role in cell cycle...

Embryos constructed through somatic cell nuclear transfer.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- Embryos were constructed through somatic cell nuclear transfer. According to recent research from Singapore, "Production of genetically identical non-human primates through somatic cell nuclear...

P16(INK4A) status independent of EBV-induced cell proliferation and latency.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- P16(INK4A) status is independent of EBV-induced cell proliferation and latency. "Epstein-Barr virus (EBV) has the ability to promote cell cycle progression following the initial infection of primary...

New antifungal agents have potential role in prophylaxis.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- New antifungal agents have a potential role in the prophylaxis of fungal infections. "Antifungal prophylaxis represents a significant advance in the management of patients at risk from fungal...

HDAC inhibitors trigger apoptosis in HPV+ cells by inducing E2F-p73 pathway.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- HDAC inhibitors trigger apoptosis in HPV+ cells by inducing the E2F-p73 pathway. "Histone deacetylase (HDAC) inhibitors induce an intrinsic type of apoptosis in human papillomavirus (HPV)-positive...

Mobilization of antiretroviral SIV gene therapy vector is feasible.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- The mobilization of an antiretroviral SIV gene therapy vector is feasible. "Exploitation of the intracellular virus machinery within infected cells to drive an anti-viral gene therapy vector may...

Polymorphism-197C/G in XBP1 may indicate a genetic risk for schizophrenia.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- A polymorphism-197C/G in XBP1 may indicate a genetic risk for schizophrenia. According to a study from China, "Schizophrenia and bipolar disorder are two major psychiatric illnesses that may share...

PRDM5 gene is silenced in human cancers and has growth-suppressive activities.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- The PRDM5 gene is silenced in human cancers and has growth-suppressive activities. According to published research from the United States, "Several genes that contain the PR (PRDI-BF1 and RIZ)...

Gliomatosis peritonei is genetically unrelated to the associated teratoma.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- Gliomatosis peritonei is genetically unrelated to the associated teratoma. "Gliomatosis peritonei, a rare condition that occurs almost exclusively in the setting of ovarian immature teratoma, is...

HSV-2 infection increases risk of HIV transmission.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- HSV-2 infection increases risk of HIV transmission. According to a study from the United States, "The synergistic relationship between herpes simplex virus type 2 (HSV-2) and transmission of human...

Lentivirus-based antisense vector inhibits HIV replication.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- "We present preclinical studies that demonstrate in vitro the feasibility and efficacy of lentivirus-based vector antisense gene therapy for control of HIV replication in primary T lymphocytes isolated...

Early HIV-1 diversity not restricted to certain risk groups/subtypes.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- Early HIV-1 diversity is not restricted to certain risk groups/subtypes. According to recent research from the United States, "African women frequently acquire several genetically distinct human...

P. jiroveci polymorphisms suggest common infection source among disease type.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- Pneumocystis jiroveci polymorphisms suggest a common infection source in AIDS patients with pneumonia and in patients with pulmonary disease. According to published research from Spain, "This study...

Fungal pheromone receptor PCSTE3 from P. carinii cloned and characterized.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- The fungal pheromone receptor PCSTE3 from Pneumocystis carinii has been cloned and characterized. "The fungal pathogen Pneumocystis carinii remains the most prevalent opportunistic infection in...

Abundant expression of granzyme A but not perforin in CD8+ cell granules in GALT.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- There is abundant expression of granzyme A but not perforin in CD8+ cell granules in GALT. "Because GALT is a major portal of entry for HIV-1 and reservoir for viral replication, we hypothesized...

Adoptive transfer of activated autologous CD4+ cells can augment immune system.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- The adoptive transfer of activated autologous CD4+ cells can augment the immune system. "We have previously shown that adoptive transfer of in vitro CD3/CD28 activated autologous CD4+ T cells...

Brownian adhesive dynamics (BRAD) simulate receptor-mediated binding of viruses.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- Brownian adhesive dynamics (BRAD) simulate receptor-mediated binding of viruses. According to a study from the United States, "Current viral docking models have relied upon the assumption that bond...

CD4+ and CD8+ T cell apoptosis inhibited by CXCR4 blockade in HIV-infected cells.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- CD4+ and CD8+ T cell apoptosis can be inhibited by the CXCR4 blockade in HIV-infected cells. According to a study from France, "Mechanisms of CXCR4-mediated T lymphocyte apoptosis in human...

EE155 region has important role in down-regulation of CD4 by HIV-1 Nef protein.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- The EE155 region has an important role in the down-regulation of CD4 by the HIV-1 Nef protein. According to a study from South Korea, "The human immunodeficiency virus (HIV) nef gene encodes a 27...

Endosome disruption enhances functional nuclear delivery of Tat-fusion proteins.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- Endosome disruption enhances functional nuclear delivery of Tat-fusion proteins. According to recent research published in the journal Biochemical and Biophysical Research Communications, "Tat...

Envelope glycoproteins not required for insertion of host ICAM-1 into HIV-1.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- Envelope glycoproteins are not required for insertion of host ICAM-1 into HIV-1. "Previous works have indicated that incorporation of surface glycoprotein into retroviruses such as the human...

Fas-mediated apoptosis increased in PMNs from HIV-infected patients.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- Fas-mediated apoptosis is increased in polymorphonuclear cells from HIV-infected patients. According to a study from Venezuela, "Neutrophils represent an important line of innate host defense...

Functional SIV nef genes allow for efficient zoonotic infection in humans.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- Functional SIV nef genes allow for efficient zoonotic infection in humans. "The accessory Nef protein allows human immunodeficiency virus type 1 (HIV-1) to persist at high levels and to cause AIDS...

HIV Env-coreceptor interactions help mediate virus-cell/cell-cell fusion.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- HIV Env-coreceptor interactions help mediate virus-cell/cell-cell fusion. "The membrane fusion events which initiate human immunodeficiency virus type 1 (HIV-1) infection and promote cytopathic...

HIV-1 promoter contains a CATA box for optimal transcription and replication.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- The HIV-1 promoter contains a CATA box for optimal transcription and replication. According to a study from the Netherlands, "The human immunodeficiency virus type 1 (HIV-1) transcriptional promoter...

HIV-1-based vector used to develop mutants incapable of developing resistance.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- An HIV-1-based vector was used to develop mutants incapable of developing resistance. "We have constructed a human immunodeficiency virus type 1 (HIV-1)-based lentiviral vector expressing a 937-base...

HIV-specific CD8+ T cells exhibit markedly reduced levels of Bcl-2 and Bcl-x[subscript]L.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- HIV-specific CD8+ T cells exhibit markedly reduced levels of Bcl-2 and Bcl-x[subscript]L. "Human immunodeficiency virus-specific CD8+ T cells are highly sensitive to spontaneous and CD95/Fas-induced...

IFN-gamma-induced inhibition of HIV replication mediated before virus entry.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- IFN-gamma-induced inhibition of HIV replication is mediated befoe virus entry. "Alterations in the expression of CXCR4 and CCR5, the co-receptors for HIV entry, may be associated with susceptibility...

Mast cells may serve as a viral reservoir for HIV-1.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- Mast cells may serve as a viral reservoir for HIV-1. "Evidence that human progenitor mast cells are susceptible to infection with CCR5-tropic strains of HIV-1 and that circulating HIV-1-infected...

Morphine prolongs survival of SIV-infected cells in early infection.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- Morphine prolongs survival of SIV-infected cells in early infection. According to recent research published in the journal Toxicology in Vitro, "Progression of HIV infections to AIDS is a complex...

Multiple HIV-1 Nef functions contribute to efficient replication in macrophages.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- Multiple HIV-1 Nef functions contribute to efficient replication in macrophages. "The human immunodeficiency virus type 1 (HIV-1) Nef protein has been shown to accelerate viral growth kinetics in...

N-linked glycosylation in CXCR4 N-terminus inhibits HIV-1 env gp binding.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- N-linked glycosylation in the CXCR4 N-terminus inhibits HIV-1 envelope glycoprotein binding. According to recent research published in the journal Virology, "CXCR4 is a co-receptor along with CD4...

Noninfectious X4 but not R5 HIV-1 inhibits lymphoid tissue antibody response.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- Noninfectious X4 but not R5 HIV-1 virions inhibit lymphoid tissue antibody response. According to recent research published in the Journal of Virology, "Ex vivo human immunodeficiency virus type 1...

Purifying selection masks mutational flexibility of HIV-1 reverse transcriptase.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- Purifying selection masks the mutational flexibility of HIV-1 reverse transcriptase. According to recent research published in the Journal of Biological Chemistry, "DNA and RNA polymerases share a...

Reduced glutathione and cysteine levels associated with HIV disease progression.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- Reduced glutathione and cysteine levels are associated with HIV disease progression. According to published research from the United States, "Plasma viral load (VL) values and CD4+ cell count are...

U937 cytokine secretion inhibited by HIV-1 gp120 C4-derived peptide constructs.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- U937 cytokine secretion is inhibited by HIV-1 gp120 C4-derived peptide constructs. According to a study from the United States, "Lipopolysaccharide (LPS) stimulation of the human promyelomonocytic...

YMDD aspartates of p66 are required and sufficient for RT polymerase function.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- YMDD aspartates of p66 are required and sufficient for RT polymerase function. "The human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) is a heterodimer comprised of two...

alpha- and theta-defensins bind with high affinity to HIV-1 gp120.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- alpha- and theta-defensins bind with high affinity to HIV-1 gp120. According to a study from the United States, "theta-Defensins are lectin-like, cyclic octadecapeptides found in the leukocytes of...

Glutamine or alanyl-glutamine improves GI symptoms and increases ART levels.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- Glutamine or alanyl-glutamine improves gastrointestinal symptoms and increases antiretroviral drug levels in HIV-infected patients. "The effects of therapy with glutamine and alanyl-glutamine on...

Maximal rate of HIV protease inhibitor resistance occurs at 87% adherence.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- The maximal rate of HIV protease inhibitor resistance occurs at 87% adherence. "The standard view postulates a bell-shaped relationship between adherence to therapy and development of drug-resistant...

Predicted efficacy of HAART for HIV-1 infection not as efficacious against HIV-2.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- The predicted efficacy of highly active antiretroviral therapy for HIV-1 infection indicates that it is not as efficacious against HIV-2 infection. According to a study from the United States,...

HIV RNA higher in rectal mucosa than blood/seminal plasma independent of ART.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- HIV RNA levels are higher in rectal mucosa secretions than in the blood or seminal plasma, independent of antiretroviral therapy. "High levels of human immunodeficiency virus (HIV) in rectal...

U.S. FDA approves Truvada as part of HIV combination therapy.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- Gilead Sciences (GILD) announced that the U.S. Food and Drug Administration (FDA) has granted accelerated approval of Truvada (emtricitabine and tenofovir disoproxil fumarate) a fixed-dose combination...

Guillain-Barre syndrome strongly associated with HIV infection in young adults.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- Guillain-Barre syndrome is strongly associated with HIV infection in young adults. "Neurological manifestations of human immunodeficiency virus (HIV) infection are frequent and several associated...

Potentially preventable infections are leading cause of HIV-related deaths.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- Potentially preventable infections are the leading cause of HIV-related deaths. According to recent research from England, "About 30 million people in Africa are estimated to be living with human...

Erythropoietin is a potent booster of metallothionein gene expression.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- Erythropoietin is a potent booster of metallothionein gene expression. According to recent research published in the journal Experimental Biology and Medicine, "recent evidence has demonstrated an...

Fanconi anemia C gene product regulates differentiation and inflammation genes.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- Fanconi anemia C gene product regulates differentiation and inflammation genes. According to published research from France, "loss of Fanconi anemia ( FA) proteins activity by recessive inherited...

Genesis to provide onsite blood coagulation monitoring with INRatio.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- HemoSense has entered into a 3-year agreement with Genesis HealthCare Corp. to use HemoSense's INRatio Prothrombin Time (PT) monitoring system in Genesis HealthCare's skilled nursing centers. The...

Major beta-thalassemia complications are primarily age-related in North America.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- Major beta-thalassemia complications are primarily age-related in North America. According to a study from the United States, "treatment of patients with beta-thalassemia major has improved...

Stage-specific cellular niches for B lymphopoiesis identified.
September 2, 2004... 2004 SEP 2 - (NewsRx.com & NewsRx.net) -- Stage-specific cellular niches for B lymphopoiesis are identified. "In bone marrow, hematopoiesis is thought to depend on special microenvironments known as niches that maintain blood cells....