Blood Weekly articles from September 2003

Blood Weekly archives from September 2003

Scientists find that stem cells in the bone marrow become liver cells.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- They still don't have a personality, and they're waiting for the maturity call. Stem cells in our bone marrow usually develop into blood cells, replenishing our blood system. However, in states of...

Drug-coated red blood cells destroy blood clots from within.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- Thrombosis is a common cause of complications and even death following surgery. To create a better means of preventing thrombosis, researchers at University of Pennsylvania School of Medicine coated red...

Drug may eliminate transfusions in patients with blood disorder.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- The use of hydroxyurea may eliminate the need for future blood transfusions in children with beta-thalassemia major, an inherited blood disorder, according to a new study. Beta-thalassemia occurs...

R-HDS regimen with stem cell autografting effective against mantle cell lymphoma.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- The R-HDS chemotherapy regimen - in combination with rituximab-purged stem cell autografts - is effective against mantle cell lymphoma (MCL). Patients suffering from MCL are "rarely cured with...

Hypoxia enhances bone marrow hematopoietic cell activity.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- Low-oxygen environments can enhance bone marrow stem cell activity. "It has been proposed that bone marrow (BM) hematopoietic stem and progenitor cells are distributed along an oxygen (O-2)...

First U.K. line generated.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- A major breakthrough has been made by U.K. researchers at King's College London in the generation of new human embryonic stem (hES) cells. The potential therapeutic value of hES in the treatment of...

Targeting TNF pathway along with ATRA may represent route to treat leukemias.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- Targeting TNF pathway along with ATRA may represent route to treat leukemias. According to a study from Canada, "The nuclear receptor ligand all-trans retinoic acid (ATRA) causes dramatic terminal...

Research hampered by shortage of monkeys.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- A nationwide shortage of rhesus macaque monkeys is hampering efforts to create cures from new information such as the human genome sequence, organ transplant techniques, and the use of stem cells to...

Immature dendritic cells have a receptor for human mannan-binding lectin.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- Monocytes and dendritic cells produce mannan-binding lectins, and immature dendritic cells have an upregulated receptor for some. "Mannan-binding lectin (MBL) is a collectin synthesized by the...

Vancomycin-resistant infections are low among liver transplant candidates.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- Vancomycin-resistant infections are low among liver transplant candidates. "The orthotopic liver transplant (OLT) population has been particularly affected by the increase in vancomycin-resistant...

A novel skin model invites new ways to explore angiogenesis in vitro.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- A novel skin model invites new ways to explore angiogenesis in vitro. "We have previously shown that reconstructed human skin engineered from autologous keratinocytes, fibroblasts, and sterilized...

All donations now screened for West Nile in U.S.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- This year, every blood donation collected in the United States is being screened for West Nile virus, according to a U.S. Centers for Disease Control and Prevention (CDC) update in Morbidity and...

FDA license granted for new HIV test kit.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- Bio-Rad Laboratories, Inc., (BIO, BIO.B) has received a license from the U.S. Food and Drug Administration for its HIV-1/HIV-2 PLUS O EIA test kit used for diagnostic testing and the screening of blood...

Antithymocyte globulin lowers GVHD, worsens T-cell deficiency.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- Antithymocyte globulin therapy in bone marrow transplant recipients lowers incidence of graft versus host disease, but extends the time of severe T cell deficiency. "The effect of antithymocyte...

Syngeneic stem cell grafts offer little improvement over autografts for breast cancer patients.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- Syngeneic stem cell grafts offer little improvement over autografts for breast cancer patients. "Metastatic breast cancer has been a common indication for autologous hematopoietic stem cell...

Cytokine imbalances mark the pathogenesis of chronic lymphocytic leukemia.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- Cytokine imbalances mark the pathogenesis of chronic lymphocytic leukemia. According to published research from Poland, "the serum concentration of two proangiogenic cytokines: basic fibroblast...

G-CSF raises GVHD but not mortality risk in matched sibling stem cell graft recipients.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- Posttransplant G-CSF treatment raises the risk of GVHD - but not overall mortality - in recipients of matched sibling stem cell grafts. According to published research from Sweden, "the effect of...

Intraoperative infusion of magnesium has beneficial effects on surgical outcome.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- Intraoperative infusion of magnesium has beneficial effects on cardiac surgical outcomes. According to recent research published in the Journal of International Medical Research, "Pre- and...

Novel gene may be involved in CLL development.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- A novel gene may be involved in leukemia pathogenesis. Scientists in Greece described "the characterization of a new gene (E4.5) that maps at chromosome band 13q14.3, a chromosomal area frequently...

Chronic-phase CML patients respond to imatinib, but questions remain.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- Chronic-phase CML patients respond to imatinib but response duration questions remain. According to recent research from the United States, "Imatinib mesylate (Gleevec, Glivec, formerly STI571;...

Gln 192 from blood coagulation factor Xa plays key role in function.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- Gln 192 from blood coagulation factor Xa helps mediate coagulation proteases and their inhibitors. "The serine protease factor Xa (FXa) is inhibited by ecotin with picomolar affinity. The structure...

Amelogenin, 17 DNA loci effective as paternity markers in incest case.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- Amelogenin and chromosome 17 DNA loci are effective as paternity markers in incest cases. Scientists in Croatia "performed a paternity test in a case of incest between brother and sister." ...

Immature dendritic cells are largely unaffected by apoptotic T cells.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- Apoptotic T cells have no major effect on immature dendritic cells, nor are they phagocytized by them; also, this does not induce them into a tolerogenic mode. "Dendritic cells (DCs) play an...

Primary ocular lymphoma is often diagnosed late, following brain metastasis.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- Primary ocular lymphoma is often diagnosed late, following metastasis. According to recent research from the United States, "Primary ocular lymphoma involves the globe in the absence of any systemic...

PAH exposure linked to DNA damage in human blood cells.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- PAH exposure is linked to DNA damage in human blood cells. In a recent study, researchers in South Korea "investigated by using comet assay the effects of polycyclic aromatic hydrocarbon (PAH) as a...

Autologous cellular therapy company receives license to manufacture in Australia.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- Isolagen, Inc., (ILE) announced it received license no. 174347 from the Therapeutic Goods Administration (TGA) in Australia to begin the manufacture of autologous fibroblasts, including the initiation...

Coagulation monitoring systems company closes latest funding round.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- HemoSense, Inc., a point-of-care blood coagulation monitoring system company, announced the closing of its latest round of funding. Participating in this round were leading medical investment firms...

Dialysis company reports second quarter and 6-month results for 2003.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- Fresenius Medical Care, AG, (FMS), a provider of dialysis products and services, announced the results for the second quarter and the first 6 months of 2003. The company reported a 7% increase in...

Grants to fund rapid, portable detection systems for HIV, blood lead.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- Alderon Biosciences of Research Triangle Park, North Carolina, announced the award of two new research grants. As the original developer and manufacturer of the LeadCare, a U.S. Food and Drug...

Hepatitis C virus patients often form elevated serum lipase levels.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- Hepatitis C virus patients often form elevated serum lipase levels. "Extrahepatic manifestations of chronic hepatitis C virus (HCV) infection have been well described. However, hyperlipasemia and/or...

TaqMan-based test provides accurate SMN copy number counts.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- A novel TaqMan-based genetic screen provides accurate copy numbers of SMN genes. SMA "is a neuromuscular disease caused by homozygous deletion of the SMN1 gene in more than 90% of patients,"...

Small interfering RNAs protect stem cells from HIV infection.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- Hematopoietic stem cells transduced with antiviral RNA become resistant to HIV infection. "The phenomenon of RNA interference mediated by small interfering RNAs (siRNAs) is a potent gene-silencing...

Acute myeloid leukemia responds to thalidomide in some patient cases.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- Acute myeloid leukemia responds to thalidomide in some patient cases. "In analogy to solid neoplasms, accumulating data suggest the requirement of angiogenesis also for the development and...

Factor VII gene intronic mutation in a lethal factor VII deficiency studied.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- Scientists have studied the factor VII gene intronic mutation in a lethal factor VII deficiency. "In a patient with lethal factor VII (FVII) deficiency, two homozygous nucleotide substitutions were...

Novel suicide fusion genes stem T cell reactions after transplantation.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- Two novel suicide fusion genes stem T cell reactions after transplantation. "Donor lymphocyte infusions (DLI) following allogeneic stem cell transplantation are known to mediate...

The best method for measuring factor VIII in plasma is the chromogenic assay.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- The best method for measuring factor VIII in plasma without concern for interference by other factors is the chromogenic assay. According to a study from the United States, "We compared 1-stage...

PMA approval granted for ProCol vascular bioprosthesis.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- Hancock Jaffe Laboratories, Inc., announced it has received U.S. Food and Drug Administration (FDA) approval to market the ProCol vascular bioprosthesis for hemodialysis access in the United States. The...

Herpesvirus 8 infection linked to hepatitis B and HIV infections in Ugandans.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- Human herpesvirus 8 infection was associated with hepatitis B and HIV infections in Ugandan blood donors. According to recent research from the United States, "Human herpesvirus 8 (HHV-8) is...

Stem cell defect underlies common genetic disorder.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- Howard Hughes Medical Institute researchers have found that Hirschsprung disease, one of the most common genetic disorders, is caused by a defect that blocks neural stem cells from forming nerves that...

Inactivated parapoxvirus ovis protects against hepatitis and herpes viruses.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- Inactivated parapoxvirus ovis protects against hepatitis and herpes viruses. "It is known that some viruses are able to induce vigorous immune reactions. This study shows that inactivated...

Bone marrow transplant has characteristic risks for pulmonary complications.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- Due to immunosuppression, there are predictable points at which there can be pulmonary complications following bone marrow transplant. "Pulmonary complications account for significant morbidity and...

Dried blood suitable for immunological RNA testing.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- Dried blood is suitable for immunological RNA testing in the field. In a recent study, scientists in Japan "examined the utility of dried blood on filter paper for the source of cytokine messenger...

Triggering receptor on myeloid cells can cause sepsis, acute inflammation.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- TREM-1, involved in triggering the hyperinflammatory response to sepsis, may be a good target for anti-sepsis drugs. "TREM-1 (triggering receptor expressed on myeloid cells), a recently discovered...

Insect sting anaphylaxis appears related to mastocytosis, urticaria pigmentosa.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- Mastocytosis and urticaria pigmentosa relate to worst cases of anaphylaxis from insect stings; monitoring of IgE and IgG may give added benefit. According to recent research from the United States,...

IVIG is immunomodulatory, anti-inflammatory, and provides passive immunization.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- Intravenous immunoglobulin acts as an immunomodulatory, anti-inflammatory, and passive immunization providing therapeutic agent. "Intravenous immunoglobulin (IVIG) preparations are fractionated...

Anemia prevalence is extremely high in renal transplant recipients.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- Anemia prevalence is extremely high in renal transplant recipients. "The Transplant European Survey on Anemia Management (TRESAM) documented the prevalence and management of anemia in kidney...

Autosomal recessive Alport syndrome can be a cause of different kidney problems.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- Autosomal recessive Alport syndrome can be a cause of kidney problems such as end stage renal disease or thin basement membrane disease. "We discuss a patient with Alport syndrome who received a...

The use of IVIG in renal transplant may help suppress panel reactive antibodies.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- The use of intravenous immunoglobulin in kidney transplant may help suppress panel reactive antibodies. "Intravenous immunoglobulin preparations (IVIG) are known to be effective in the treatment of...

Childhood survivors not receiving radiation have same life expectancy as general population.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- A new study from St. Jude Children's Research Hospital indicates that survivors of childhood acute lymphoblastic leukemia (ALL) who have not received radiation treatment as part of their therapy have...

Targeted approaches may lead to better treatment of chronic lymphocytic leukemia.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- Targeted approaches may lead to better treatment of chronic lymphocytic leukemia. "Chronic lymphocytic leukemia therapy has changed dramatically over the past decade, with recent studies supporting...

Tumors with a high proliferation index have a poor prognosis.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- Tumors with a high proliferation index have a poor prognosis. "Microarrays for gene expression profiling are rapidly becoming important research tools for the identification of novel markers, for...

User-defined assays may have applicability in management of leukemia.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- User-defined assays may have applicability in management of leukemia. "An increasing number of risk-stratifying genetic lesions in acute leukemia are being discovered and characterized," scientists...

AML karyotype strongly influences benefits of pre-HSCT consolidation chemotherapy.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- The benefits of intensive consolidation chemotherapy before stem cell transplantation for AML may be limited to patients with good karyotypes. In a recent study from England, "a total of 81 adults...

Hybrid artificial liver support systems can stem hepatic decline.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- Hybrid artificial liver support systems can stem hepatic decline. According to recent research from the Peoples Republic of China, "artificial liver support system (ALSS) has been used to treat...

Prothrombinase generates thrombosis formation in viral hepatitis infections.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- Prothrombinase generates thrombosis formation in viral hepatitis infections. According to a study from Canada, "fibrin deposition and thrombosis within the microvasculature is now appreciated to...

Left liver grafts are successful for patients with MELD score less than 15.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- Left liver grafts are successful for patients with MELD score of less than 15. According to published research from Japan, "Left liver grafts are now seldom used for adult recipients of living donor...

Mesenteric malignant lymphoma detected by routine color Doppler ultrasonography.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- Mesenteric malignant lymphoma can be detected by routine color Doppler ultrasonography. According to recent research from Japan, "This report concerns a case of primary mesenteric malignant lymphoma...

The anti-CD20 monoclonal antibody rituximab is generally well tolerated.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- The anti-CD20 monoclonal antibody rituximab is generally well tolerated. "The chimeric anti-CD20 monoclonal antibody rituximab has become part of the standard therapy for patients with non-Hodgkin's...

P. falciparum hastens red blood cell senescence.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- Malaria parasites hasten red blood cell senescence. "Red blood cells infected with Plasmodium falciparum (IRBCs) undergo changes primarily in their membrane composition that contribute to malaria...

There are three different models for schistosomiasis transmission.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- The mode of schistosomiasis transmission is considered using three different mathematical models. According to a study from Brazil, "In order to analyze the effects of acquired immunity and the...

Hemoglobin levels affect outcomes in pregnant African-American adolescents.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- Hemoglobin levels affect outcomes in pregnant African-American adolescents. According to a study from the United States, "relationships between hemoglobin concentrations and birth outcomes have not...

Myeloma cell contamination minimal in melphalan-mobilized stem cell grafts.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- Myeloma cell contamination is minimal in melphalan-mobilized stem cell grafts. "Optimal methods of stem cell mobilization in multiple myeloma are undefined, and contaminating clonotypic cells could...

Thalidomide has been found to be effective for relapsed or refractory myeloma.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- Thalidomide has been found to be effective for relapsed or refractory myeloma. "Since new treatments have recently been proposed for patients with multiple myeloma, the aim of this article is to...

Enzyme changes cause different abnormalities in oocytes and bone marrow cells.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- Enzyme changes cause different abnormalities in oocytes and bone marrow cells. According to a study from the United States, "protein tyrosine phosphatases are needed for activating maturation...

Healing the heart with stem cells.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- Genetically engineered stem cells can restore heart performance and repair the damage caused by a heart attack, according to a new study. Researchers have tried for years to repair damaged hearts...

Acute pancreatitis can occur during painful sickle cell vaso-occlusive crisis.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- Acute pancreatitis can occur during painful sickle cell vaso-occlusive crisis. According to a study from the United States, "Sickle cell disease is characterized by chronic hemolytic anemia and...

Trypanosomes lacking pre-mRNA, gRNA still form functional RNA-editing complexes.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- Trypanosomal organisms lacking in pre-mRNA or gRNA still can form RNA-editing complexes that do not appear to differ functionally from wild type. "Mitochondrial pre-mRNAs undergo...

Placental villotrophoblastic pulmonary emboli can occur following abortion.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- Pulmonary emboli of chorionic villus origin can occur following abortion as well as in pregnancy. According to a study from Japan, "Although pulmonary trophoblastic embolism is now considered a...

Macrophage migration inhibitory factor acts in septic shock, may be good target.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- Since macrophage migration inhibitory factor is involved in signaling to do with septic shock, it may be a target for controlling septic shock in patients. According to recent research from...

Beer-derived beta-pseudouridine protects against radiation-induced chromosome damage.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- Beer-derived beta-pseudouridine protects blood cells from radiation-induced chromosome damage. Scientists from Japan had "previously found that drinking beer reduces chromosome aberrations in blood...

Aegle marmelos extract prevents radiation damage in blood cells.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- An extract from an Indian religious plant can protect blood cells from radiation damage. In a recent study from India, "the radioprotective effect of a hydroalcoholic extract of Aegle marmelos (AME)...

NF-kappa B increases occur with organ failure; targeting it may reduce risk.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- Sepsis associated organ failure occurs following increased NF-kappaB; targeting it may reduce risk. According to recent research published in the Journal of Infectious Diseases, "Nuclear factor...

Bone marrow cells aid repair of necrotic renal tubules.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- Bone marrow stem cells play a key role in the repair of necrotic renal tubules. "The paradigm for recovery of the renal tubule from acute tubular necrosis is that surviving cells from the areas...

Bone marrow derived cells could heal organs through wound entry.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- Bone marrow derived cells could heal organs through wound entry. "Bone marrow has long been known to be a source of stem cells capable of regeneration of the hematopoietic system. Recent reports,...

Diclofenac is toxic to neural stem cells.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- The anti-inflammatory agent diclofenac is toxic to neural progenitor cells. "Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used in clinical situations as anti-inflammatory, analgesic and...

Gene expression profiles predict outcomes following bone marrow transplants.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- Gene expression profiles predict outcomes following bone marrow transplants. "The liver, skin, and gastrointestinal tract are major target organs of acute graft-versus-host disease (GVHD), the major...

Novel P2Y receptor regulates primitive hematopoietic cell activity.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- A novel P2Y-like receptor regulates primitive hematopoietic cell activity. "Hematopoiesis in mammals undergoes a developmental shift in location from fetal liver to bone marrow accompanied by a...

Slug transcription factor needed for SCF/c-kit-mediated stem cell radioresistance.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- The zinc-finger transcription factor Slug is needed for hematopoietic cell radioresistance mediated by the SCF/c-kit pathway. "Radiation-induced destruction of the hematopoietic system is the...

TCRbeta enhancer activity characterized in T-cell progenitors.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- The activity and function of the TCRbeta enhancer in T-cell progenitors has been characterized. According to recent research from the United States, "previous studies have shown that murine bone...

Airflow obstruction common after myeloablative stem cell transplants.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- Potentially fatal respiratory problems after myeloablative stem cell transplantation develop at an unexpectedly high rate. "Despite advances in the management of myeloablative allogeneic...

Common lymphoid progenitors enhance immune recovery in stem cell graft recipients.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- A rare subset of lymphoid progenitor cells can safely enhance immune recovery after stem cell transplantation. "Lymphoid deficiency after allogeneic hematopoietic cell transplantation (HCT) results...

Donor DNA chimerism monitoring useful in high-risk stem cell graft recipients.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- Donor DNA chimerism monitoring can aid the treatment of stem cell transplant recipients with a high risk of graft failure. In a recent study, scientists in Hong Kong "analyzed the clinical course...

Donor memory T cells do not induce graft-versus-host disease.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- Donor memory T cells do not induce graft-versus-host disease (GVHD). GVHD "remains a major cause of morbidity and mortality in allogeneic stem cell transplantation (alloSCT)," scientists in the...

GVHD, glucocorticoid treatment impair IPC recovery in stem cell recipients.
September 4, 2003... 2003 SEP 4 - (NewsRx.com & NewsRx.net) -- Glucocorticoid treatment and graft-versus-host reactions impair IPC recovery after stem cell transplantation. "Delayed recovery of the immune system is a major cause of post-transplant infection,"...