Blood Weekly articles from October 2008

Blood Weekly archives from October 2008

New gene variant identified for nondiabetic end stage renal disease in African-Americans.
October 2, 2008... Scientists at Johns Hopkins schools of Public Health and Medicine have, for the first time, identified variants in the gene MYH9 that are associated with increased risk for non-diabetic end stage renal disease (ESRD,) which is the near-loss of...

Strategies for preventing gastrointestinal complications in severely burned patients.
October 2, 2008... Gastrointestinal dysfunction is a common complication of severe burns. Injury to GI function, especially to GI barrier function, is an important initiator as well as a stimulator for occurrence of systemic inflammatory response syndrome, sepsis...

American College of Physicians Issues Guideline for Drug Treatment of Men and Women with Osteoporosis or Low Bone Density.
October 2, 2008... The American College of Physicians (ACP) released a new clinical practice guideline on drug treatment of osteoporosis or low bone density to prevent fracture in men and women. The guideline appears in the September 16, 2008, issue of Annals of...

Study results from George Washington University in the area of angiology published.(Clinical report)
October 2, 2008... "Blood O-2 saturation and lactate concentration gradients from superior vena cava (SVC) to pulmonary artery (PA) occur in critically ill patients. These gradients (Delta SO2 and Delta[Lac]) may be positive or negative," scientists in the United...

Cyclacel Expands Phase 2 Sapacitabine Trial in Elderly AML to Include Patients With MDS.
October 2, 2008... Cyclacel Pharmaceuticals, Inc. (NASDAQ:CYCC) (NASDAQ:CYCCP) announced that it has advanced sapacitabine into Phase 2 development as a second-line treatment for myelodysplastic syndromes (MDS). The MDS study is designed as a protocol amendment...

New findings from K. Abhishek and co-authors in the area of hypotension published.
October 2, 2008... According to recent research from the United States, "Acute ischemia of the rectum is uncommon and usually occurs after aorto-iliac surgery. In this report, we present a case of acute ischemic proctosigmoiditis that developed from a brief...

Research reports on life sciences from Stanford University provide new insights.(Report)
October 2, 2008... "Strict glucose control with insulin is associated with decreased mortality in a mixed patient population in the intensive care unit. Controversy exists regarding the relative benefits of glucose control versus a direct advantageous effect of...

Scientists at Beaumont Hospital release new data on life sciences.
October 2, 2008... "Point prevalence surveys are useful in detecting changes in the pattern of healthcare-associated infection (HCAI). In 2004 the Hospital Infection Society was asked to conduct a third national. prevalence survey, which included U.K., Wales,...

Studies from R.S. Wiener et al have provided new data on life sciences.
October 2, 2008... According to a study from the United States, "Context The American Diabetes Association and Surviving Sepsis Campaign recommend tight glucose control in critically ill patients based largely on 1 trial that shows decreased mortality in a...

New findings in liver cirrhosis described from University of California.
October 2, 2008... "Fungal sepsis after ureteroscopy (URS) is rarely reported. We report on 2 cases of acute fungemia that developed after routine ureteroscopic stone manipulation in patients with advanced liver cirrhosis," investigators in the United States...

New liver transplant study findings have been reported by P. Feltracco and colleagues.
October 2, 2008... According to a study from Padua, Italy, "Severe infectious diseases after liver transplant are associated with high risk of multiorgan failure and mortality. Septic shock is difficult to manage in this setting since it is often unresponsive to...

Report summarizes neutropenia study findings from G. Dranitsaris and co-researchers.
October 2, 2008... In this recent report published in the American Journal of Clinical Oncology - Cancer Clinical Trials, researchers in Toronto, Canada conducted a study "To develop a cycle-based. risk prediction model for neutropenic complications (NC) during...

Data on sepsis detailed by L. Tuon and co-authors.
October 2, 2008... In this recently published article, scientists in Criciuma, Brazil conducted a study "To evaluate the cognitive performance in rats that survived sepsis induced by cecal ligation and puncture (CLP) after 10, 30 and 60 days." "Prospective,...

Findings in sepsis reported from University of Michigan.(Report)
October 2, 2008... According to recent research from the United States, "IL-17A is a proinflammatory cytokine produced by a variety of cells. In the current study, we examined the role of IL-17A in sepsis induced in mice by cecal ligation and puncture (CLP)." ...

New sepsis research from University of Turin described.(Report)
October 2, 2008... In this recent report, researchers in Turin, Italy conducted a study "To test the hypothesis that extracorporeal therapy with polymyxin B (PMX-B) may prevent Gram-negative sepsis-induced acute renal failure (ARF) by reducing the activity of...

Reports outline sepsis research from University of Padua.
October 2, 2008... In this recently published article, scientists in Padua, Italy conducted a study "To describe the efficacy and safety of protein C (PC) concentrate to restore physiological values in adult septic patients having clinical contraindications to...

Research conducted at University of Michigan has provided new information about sepsis.
October 2, 2008... In this recently published article, scientists in the United States conducted a study "To assess the association between Staphylococcus aureus (S. aureus) blood stream infections (BSIs) and morbidity and mortality in older adults....

Research from University of Queensland in the area of sepsis described.
October 2, 2008... In this recently published study, investigators in Australia conducted a study "To compare the time course of organ dysfunction/failure, mortality and cause of death in patients with severe sepsis (SS) and patients with severe non-infectious...

Research from National Heart, Lung, & Blood Institute has provided new information about sickle cell anemia.
October 2, 2008... "In addition to vaso-occlusion by sickled erythrocytes, the pathophysiology of sickle cell disease (SCD) is compounded by the diminished bioavailability of nitric oxide (NO), associated with vasoconstriction, endothelial activation and cell...

Research from University of Amsterdam in the area of sickle cell anemia published.
October 2, 2008... "Obstruction of the microcirculation is the most important cause of painful crisis in sickle cell disease (SCD). Extensive microvascular obstruction has been observed in mouse models of SCD," scientists in Netherlands report (see also Sickle...

Researchers from University of Hong Kong publish findings in thyroid cancer.
October 2, 2008... According to recent research published in the journal Annals of Surgical Oncology, "Anaplastic thyroid carcinoma (ATC) is a notoriously aggressive malignancy associated with a highly lethal clinical course despite therapeutic intervention. Our...

New urinary tract infection study results from Washington University described.(Report)
October 2, 2008... According to a study from the United States, "Nosocomial infections are problematic in the ICU because of their frequency, morbidity, and mortality. The most common ICU infections are pneumonia, bloodstream infection, and urinary tract...

Reports summarize coagulation study results from Case Western Reserve University.
October 2, 2008... Scientists discuss in 'The elusive physiologic role of Factor XII' new findings in coagulation. "Physiologic hemostasis upon injury involves many plasma proteins in a well-regulated cascade of proteolytic reactions to form a clot. Deficiency of...

New findings from J. Bordes and co-authors in the area of life sciences published.(Clinical report)
October 2, 2008... A new study, 'A non-surgical device for faecal diversion in the management of perineal burns,' is now available. According to a study from France, "Burns to the perineal, buttock and upper thigh areas are frequently exposed to continual faecal...

Reports summarize pediatric in children study results from Medical College, Department of Paediatrics.
October 2, 2008... Data detailed in 'Fetal ascites owing to congenital cytomegalovirus: response to ganciclovir' have been presented. "A term newborn with severe congenital cytomegalovirus (CMV) infection is described. Fetal ascites was detected at 28 weeks...

Researchers at Emory University have published new data on life sciences.
October 2, 2008... A new study, 'The carbon monoxide diffusing capacity: clinical implications, coding, and documentation,' is now available. "The test for the diffusing capacity of the lung for carbon monoxide (DLCO) has been available for nearly 100 years for...

Researchers from National Institutes of Health report details of new studies and findings in the area of life sciences.
October 2, 2008... Investigators publish new data in the report 'Effects of (-)-epigallocatechin gallate on the redox reactions of human hemoglobin.' According to a study from the United States, "The toxicity of acellular hemoglobin (Hb)-based therapeutics has...

Researchers from University of Sao Paulo, Department of Infectious Diseases publish findings in life sciences.(Report)
October 2, 2008... Current study results from the report, 'Investigation of an outbreak of Enterobacter cloacae in a neonatal unit and review of the literature,' have been published. According to a study from Sao Paulo, Brazil, "Enterobacter cloacae has emerged...

Research from C. Glass and co-authors reveals new findings on lymphoma therapy.
October 2, 2008... Fresh data on lymphoma are presented in the report 'Role of the primary care physician in Hodgkin lymphoma.' According to a study from the United States, "Approximately 8,200 new cases of Hodgkin lymphoma are diagnosed annually in the United...

Data on nosocomial infections described by researchers at Niigata University.
October 2, 2008... Current study results from the report, 'Bacillus cereus nosocomial infection from reused towels in Japan,' have been published. "It was noticed that there was an increase in Bacillus cereus nosocomial infections in the summer from 2000 to 2005....

New Cross Hospital details research in nosocomial infections prevention.(Report)
October 2, 2008... Data detailed in 'A randomized controlled trial on cross-infection control in maxillofacial trauma surgery: a comparison of intermaxillary fixation techniques' have been presented. "Glove perforations and percutaneous injuries occur commonly...

Findings from Iran University, Infectious Diseases Research Center provide new insights into sepsis.(Report)
October 2, 2008... A report, 'Comparison of WBC, ESR, CRP and PCT serum levels in septic and non-septic burn cases,' is newly published data in Burns. According to a study from Iran, "Diagnosis of sepsis is difficult, particularly in cases of burn where signs of...

Reports from Johns Hopkins University highlight recent research in sepsis.
October 2, 2008... Researchers detail in 'Pulmonary vs nonpulmonary sepsis and mortality in acute lung injury,' new data in sepsis. According to a study from the United States, "Acute lung injury (ALI) is a frequent complication of sepsis. It is unclear if a...

Studies from University of Southern California, Department of Diagnostic Radiology yield new data on sickle cell anemia.
October 2, 2008... Researchers detail in 'Magnetic resonance detection of kidney iron deposition in sickle cell disease: a marker of chronic hemolysis,' new data in sickle cell anemia. In this recent study, researchers in the United States conducted a study "To...

Study findings from A.W. Al-Saqladi et al provide new insights into sickle cell anemia in children.(Report)
October 2, 2008... Research findings, 'Growth and nutritional status of children with homozygous sickle cell disease,' are discussed in a new report. "Poor growth and under-nutrition are common in children with sickle cell disease (SCD). This review summarises...

Researchers' work from Dartmouth University, Norris Cotton Cancer Center focuses on thalassemia therapy.
October 2, 2008... New investigation results, 'A cell stress signaling model of fetal hemoglobin induction: what doesn't kill red blood cells may make them stronger,' are detailed in a study published in Experimental Hematology. According to recent research...

New adenoidectomy findings from Medical University of Vienna published.(Report)
October 2, 2008... According to recent research published in the journal Wiener Klinische Wochenschrift, "Purpose of the investigation: Tonsillectomy and adenoidectomy are the most common surgical procedures in otorhinolaryngology. The most serious complication...

Data on agammaglobulinemia published by J. Shiraishi and colleagues.
October 2, 2008... According to a study from Tokyo, Japan, "Reported herein is a case of type AB thymoma accompanied by pure red cell aplasia (PRCA) and Good syndrome. The patient was a 55-year-old woman who was found to be anemic and to have an abnormal shadow...

Study data from S.H. Chen and co-authors update knowledge of alcoholism.(Report)
October 2, 2008... "This study analyzes the effect of the val227ala variant of the peroxisome proliferators-activated receptor-alpha (PPAR-alpha) on non-alcoholic fatty liver disease. 79 patients with NAFLD and 63 healthy counterparts were included in the study,"...

Reports on allergies findings from U. Baranyi and co-researchers provide new insights.
October 2, 2008... According to recent research from Vienna, Austria, "Allergy represents a hypersensitivity disease that affects >25% of the population in industrialized countries. The underlying type I allergic immune reaction occurs in predisposed atopic...

Investigators at Stanford University target allograft rejection.
October 2, 2008... "Intra-graft CD20(+) B-cell clusters are found during acute rejection of renal allografts and correlate with graft recovery following rejection injury. Here using archived kidney tissue we conducted immunohistochemical studies to measure...

New ampullary cancer study results from H.S. Yao et al described.(Report)
October 2, 2008... According to recent research from Shanghai, People's Republic of China, " Allogeneic blood transfusion (ABT) containing packed red blood cells (RBCs) has a known immunosuppressive effect that may affect cancer metastases and recurrence. This...

Research reports on anatomy from Erasmus University provide new insights.
October 2, 2008... "Live donor kidneys with multiple arteries are associated with surgical complexity for removal and increased rate of recipient ureteral complications. We evaluated the outcome of vascular imaging and the clinical consequences of multiple...

Scientists at University of Helsinki release new data on anesthesia.(Clinical report)
October 2, 2008... "No validated monitoring method is available for evaluating the nociception/antinociception balance. We assessed the surgical stress index (SSI), computed from finger photoplethysmographic waveform amplitudes and pulse-to-pulse intervals, in...

Study findings from University of Louvain broaden understanding of aneurysm.
October 2, 2008... According to a study from Brussels, Belgium, "Capillary malformation-arteriovenous malformation (CM-AVM) is a newly recognized autosomal dominant disorder, caused by mutations in the RASA1 gene in six families. Here we report 42 novel RASA1...

Recent studies by Z. Huang and co-authors add new data to angiotensins findings.
October 2, 2008... According to recent research from Stockholm, Sweden, "Patients with diabetes are often treated with a statin for hyperlipidaemia and an ACE (angiotensin-converting enzyme) inhibitor or angiotensin receptor antagonist for hypertension or...

Studies from F. Zhu et al provide new data on angiotensins.
October 2, 2008... "Agonistic AT, receptor autoantibodies (AT(1)-AAs) have been described in the patients with malignant hypertension or preeclampia. Furthermore, AT(1)-AAs were highly associated with refractory hypertension," scientists in Wuhan, People's...

Research from S. Pendle and co-authors provides new data about anti-infectives.
October 2, 2008... "Between June and November 2004, a vancomycin-resistant Enterococcus faecium (VRE) strain was isolated from 13 patients in the haematology/bone marrow transplant unit. There were difficulties in identifying the organism, which had low-level,...

New antithrombotics study results from E.M.A. Barroso et al described.
October 2, 2008... According to a study from Natal, Brazil, "Fucan is a term used to denominate a family of sulfated L-fucose-rich polysaccharides. The brown alga Spatoglossum schroederi(Dictyotaceae) has three heterofucans namely fucan A, B and C. The 21 kDa...

New aortic dissection research has been reported by scientists at Stanford University, Medical Department.(Clinical report)
October 2, 2008... According to recent research from the United States, "This study assessed midterm results of emergency endovascular stent-grafting for patients with life-threatening complications of acute type B aortic dissection. Between November 1996 and...

Data on aortic stenosis described by researchers at University Hospital.
October 2, 2008... "Hypertension is a frequent finding in patients with aortic stenosis (AS). However, controversial data about the influence of systemic blood pressure on the quantification of AS have been published," researchers in Munster, Germany report (see...

Studies from Osaka University provide new data on apoptosis.
October 2, 2008... According to recent research from Suita, Japan, "The present study employed immunohistochemistry for single-stranded DNA (ssDNA) to detect apoptotic cells in taste buds of the rat circumvallate papilla. Double-labeling of ssDNA and markers for...

Study findings from University of South Australia, Medical Department broaden understanding of apoptosis.
October 2, 2008... "There is great interest in the potential chemopreventive activity of resveratrol against human cancers. However, there are conflicting results on its growth inhibitory effect on normal cells," investigators in Adelaide, Australia report (see...

Research from University of Chile has provided new data on arthritis.
October 2, 2008... According to a study from Santiago, Chile, "The use of regulatory or immature dendritic cells (DCs) as tools for modulating experimental rheumatoid arthritis is very recent. Tumour necrosis factor (TNF)-stimulated DCs have been shown to restore...

Findings from Medical University of Vienna in artificial organs reported.
October 2, 2008... "A proof of concept for the evaluation of external nerve and muscle fiber excitation with the finite element software COMSOL Multiphysics, formerly known as FEMLAB, is presented. This software allows the simultaneous solution of fiber...

Findings in artificial organs reported from University of Salford.
October 2, 2008... According to a study from Salford, the United Kingdom, "Discomfort experienced during surface functional electrical stimulation (FES) is thought to be partly a result of localized high current density in the skin underneath the stimulating...

Reports summarize artificial organs research from M. Lawrence and co-authors.
October 2, 2008... "New multichannel textile neuroprotheses were developed, which comprise multiple sets of transcutaneous electrode arrays and connecting wires embroidered into a fabric layer. The electrode arrays were placed on the forearm above the extrinsic...

Reports summarize artificial organs study results from University of Berlin.
October 2, 2008... According to a study from Berlin, Germany, "The topic of this contribution is iterative learning control of a drop-foot stimulator in which a predefined angle profile during the swing phase is realized. Ineffective dorsiflexion is compensated...

Research on artificial organs detailed by U.S. Hofstoetter and co-authors.
October 2, 2008... According to a study from Vienna, Austria, "Dynamic task-dependent regulation of reflexes controlled by the central nervous system plays an integral part in neurocontrol of locomotion. Such modifications of sensory-motor transmission can be...

Researchers from University of Liverpool discuss findings in artificial organs.
October 2, 2008... "For many years there has been a dearth of effective treatment options for the severe wasting and secondary consequences of motor nerve injury," scientists writing in the journal Artificial Organs report (see also Artificial Organs). "In...

Studies from J. Rozman and co-researchers yield new data on artificial organs.
October 2, 2008... "The article presents the results of modeling, design, and experimental testing of a multielectrode spiral cuff (CUFF) to determine to what extent a CUFF could be used for selective stimulation of different types of nerve fibers within...

Studies from Y. Stickler and co-researchers update current data on artificial organs.
October 2, 2008... "The complete denervation of muscles leads to changes in the muscle fibers as well as in the surrounding tissue. Concerning excitability the most important changes are reductions in fiber diameter, in muscle cross-sectional area, and in...

Data on atherosclerosis reported by S. Poitevin and co-researchers.
October 2, 2008... "Tissue factor (TF), the main trigger of coagulation cascade, is a major component of the atherosclerotic plaque. Matrix metalloproteinases (MMPs) are recognized as key mediators of extracellular matrix remodeling during inflammation,"...

New atherosclerosis findings from Duke University described.
October 2, 2008... According to a study from the United States, "Atherosclerosis and arterial injury-induced neointimal hyperplasia involve medial smooth muscle cell (SMC) proliferation and migration into the arterial intima. Because many 7-transmembrane and...

Scientists at Medical University of Vienna publish research in atherosclerosis.
October 2, 2008... According to a study from Vienna, Austria, " Along the internal carotid artery (ICA), atherosclerotic plaques are often located in its cavernous sinus (parasellar) segments (pICA). Studies indicate that the incidence of pre-atherosclerotic...

New atorvastatin findings from University of Texas published.
October 2, 2008... " We asked whether caffeinated coffee ( CC) blunts the infarct size ( IS)-limiting effects of atorvastatin ( ATV). Adenosine receptor activation is essential for mediating the IS-limiting effects of statins," investigators in the United States...

Data from D.J. Elliott and colleagues advance knowledge in atrial fibrillation.
October 2, 2008... " Atrial fibrillation is the most common significant cardiac arrhythmia and substantially impacts the health status of patients. Enoxaparin has been shown to be a safe and effective alternative to unfractionated heparin for use with...

Research on atrial fibrillation reported by A.M. Gallagher et al.(Report)
October 2, 2008... "Practice guidelines recommend long-term stroke prophylaxis in patients with chronic atrial fibrillation (cAF). To examine treatment initiation and persistence and factors that influence the choice of cAF treatment," scientists writing in the...

Research from H.Y. Dong and co-researchers in the area of B-cell lymphoma published.(Report)
October 2, 2008... "The B-cell-specific transcription factor PAX-5 is physiologically expressed in normal B cells and silenced in plasma cells. The aim of this study was to determine whether PAX-5 expression is universal among B-cell malignancies," scientists in...

Scientists at Seoul National University, Medical Department target B-cell lymphoma.
October 2, 2008... "Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease with various genetic alterations. The aim was to investigate MYC, Bcl-2 and Bcl-6 translocations and copy number changes adult DLBCLs to evaluate their clinicopathological...

Study data from Sahlgrenska University update knowledge of B-cell lymphoma.
October 2, 2008... According to recent research published in the journal Pathology International, "Tumor-associated macrophages (TAM) have been ascribed both pro- and anti-tumor properties, but the majority of clinical cancer studies have shown that the presence...

Research from Peking University has provided new data on behavior.(Report)
October 2, 2008... "The aim of this study was to investigate the electrochemical behavior of Ti50N47.2CO2.8 alloy in deaerated artificial saliva solutions with binary NiTi alloy as reference and to characterize the composition and structure of the passive film...

New biomedicine research has been reported by scientists at University of Wisconsin.
October 2, 2008... "Elastomers based on poly(dimethylsiloxane) (PDMS) are promising materials for fabrication of a wide range of microanalytical systems due to their mechanical and optical properties and ease of processing. To date, however, quantitative studies...

Study results from University of Cape Town update understanding of biomedicine.
October 2, 2008... According to a study from Cape Town, South Africa, "Data from African countries indicate that men and women attribute infertility to traditional beliefs about health and disease as well as to biomedical causes, although appropriate knowledge of...

Findings from L.B.M. Resstel et al in blood pressure reported.
October 2, 2008... "1. Increased plasma homocysteine content and increased blood pressure are independently associated with higher cardiovascular risks," scientists in Ribeirao Preto, Brazil report (see also Blood Pressure). "The present study was designed...

New blood pressure study findings recently were reported by S.A. Takmaz and co-researchers.(Clinical report)
October 2, 2008... "To evaluate the efficacy of 2 different doses of intravenous lornoxicam for pain relief during shock wave lithotripsy (SWL). In this randomized, controlled, double-blind study, 60 ASA I-II patients undergoing SWL were randomly divided into 3...

Research results from Chiba University, Medical Department update knowledge of blood pressure.
October 2, 2008... "To clarify the effect of shift work on blood pressure in Japanese men, a 14-year historical cohort study was conducted in day workers (n = 3963) and alternating shift workers (n = 2748) who received annual health checkups between 1991 and 2005...

Studies from University of Barcelona have provided new data on blood pressure.
October 2, 2008... In this recent study, researchers in Barcelona, Spain conducted a study "To evaluate the impact of early blood pressure (BP) changes on diffusion-weighted imaging (DWI) lesion evolution and clinical outcome in patients with stroke treated with...

Investigators at University of London, Imperial College have published new data on bone marrow.
October 2, 2008... According to recent research from Harrow, the United Kingdom, "Dendritic cells stimulate primary T-cell responses and a major activation route is via presentation of antigens pre-processed by other dendritic cells. This presentation of...

Study findings from Henry Ford Hospital provide new insights into brain cancer.
October 2, 2008... "Secreted protein acidic and rich in cysteine (SPARC) regulates cell-extracellular matrix interactions that influence cell adhesion and migration. We have demonstrated that SPARC is highly expressed in human gliomas, and it promotes brain tumor...

Research on cancer detailed by D. Ducloux and co-authors.(Report)
October 2, 2008... "Serum levels of 25-OH-D-3 inversely correlate with the incidence of various types of cancers in the general population. Because risk factors and incidence of cancer in renal transplant recipients (RTRs) are different from the general...

Researchers from University of Ghent provide details of new studies and findings in the area of cardiology.
October 2, 2008... "In contrast to the plethora of vasculopathies to which oxidized low-density lipoprotein cholesterol ( ox-LDL) can be linked, there are no data linking ox-LDL to myocardial ( dys) function in the community. We tested whether ox-LDL, a marker of...

Research reports on cardioprotection from Aarhus University provide new insights.
October 2, 2008... According to recent research from Aarhus, Denmark, "1. Previously, we found that administration of high-dose L-glutamate during postischaemic reperfusion improves haemodynamic recovery and enhances glycogen resynthesis." "In the present...

New cardiovascular disease study findings recently were reported by researchers at College of Medicine.
October 2, 2008... According to recent research from the United States, "Sodium restriction is commonly recommended as a measure to lower blood pressure and thus reduce cardiovascular disease (CVD) and all-cause mortality. However, some studies have observed...