Blood Weekly articles from October 2003

Blood Weekly archives from October 2003

Intensive SCT conditioning regimen effective for high-risk leukemia patients.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- Despite high toxicity, an intensive stem-cell transplantation conditioning regimen can improve the outcome for high-risk leukemia patients. "The major cause for failure of autologous stem-cell...

Oral tolerance induction may reduce GVHD risk in stem-cell graft recipients.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- Oral tolerance induction may reduce the risk graft-versus-host disease (GVHD) in stem-cell graft recipients. GVHD "is the major obstacle for successful allogeneic stem-cell transplantation (SCT),"...

Novel LC-based assay detects Hemopure doping in athletes.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- A novel liquid chromatography (LC)-based assay can be used to detect Hemopure doping by athletes. "Since January 2000, hemoglobin-based oxygen carriers, such as Hemopure, belong to the list of...

Stem cell transplantation benefits confirmed for pediatric CML patients.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- The benefits of hematopoietic stem-cell transplantion (SCT) for pediatric chronic myeloid leukemia (CML) patients have been confirmed. SCT "is the only proven cure" for CML, "a rare disease in...

Fludarabine-melphalan regimen increases post-SCT T-cell engraftment, GVHD risk.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- Conditioning with fludarabine and melphalan increases the rate of T-cell engraftment - and the risk of GVHD - in stem-cell transplant recipients. "Hematopoietic stem-cell transplantation may be used...

Monthly chimerism analysis can predict stem-cell graft failure.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- Monthly chimerism analysis can identify patients with a high risk of graft failure after stem-cell transplantation. In recent study from South Korea, "hematopoietic chimerism (HpC) was assayed...

CD8 T, CD16 NK have different telomere shortening rates, telomerase activity.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- Aging based on telomere length and telomerase activity are different in CD8 T and CD16 NK cells; NK have telomerase activity and delayed senescence. "Telomeres are specialized structures located at...

Hepcidin is critical for iron transport, macrophage iron collection.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- Hepcidin is critical for iron transport, macrophage iron collection; lack of it can produce hemochromatosis. According to recent research published in the journal Blood, "Human hepcidin, a 25-amino...

Transcription coactivator OCA-B gene may be involved in B-cell expansion.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- The OCA-B gene is needed after B-cell receptor ligation and T helper costimulation, and appears to be involved in signaling B-cell expansion. "The tissue-specific transcriptional coactivator OCA-B...

Alpha-proteobacterium in an immunocompetent geriatric patient causes bacteremia.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- Bacteremia in an immunocompetent geriatric patient is caused by a new organism, an alpha-proteobacterium. According to recent research from North Ireland, "An 89-year-old male with pyrexia and...

Trials for investigational pathogen inactivation system halted.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- Cerus Corporation (CERS) and subsidiaries of Baxter International, Inc., (BAX) announced that they are voluntarily halting phase III trials for their pathogen-inactivated red blood cell program. ...

Primary central nervous system lymphoma can have cryoglobulin deposits.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- Primary CNS lymphoma can have associated cryoglobulins too. "Primary central nervous system lymphomas (PCNSLs) represent malignant non-Hodgkin B-cell lymphomas confined to the central nervous...

Dosing regimens polarize the mobility and viability of vessel progenitor cells.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- Dosing regimens polarize the mobility and viability of vessel progenitor cells. According to published research from Italy, "there is growing evidence that vasculogenesis (progenitor cell-derived...

10-Minute cardiac troponin I test receives U.S. FDA clearance.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- i-STAT Corporation (STAT), a manufacturer of point-of-care diagnostic systems for blood analysis, has received U.S. Food and Drug Administration clearance to market its 10-minute i-STAT System Cardiac...

Novel source found in human embryonic stem-cell-derived cardiomyocytes.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- Adult heart cells have limited regenerative capacity and therefore any significant cell loss, such as occurs during a heart attack, is mostly irreversible and may lead to the development of progressive...

C-section has minor risk of maternal HSV-2 brain inflammation.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- Cesarean sections can have an HSV-2 meningitis or encephalitis risk for the mother. "Herpes simplex virus type 2 (HSV-2) encephalitis is rare, especially during pregnancy. In immunocompetent...

Several hematologic disorders are linked to hepatitis C virus infection.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- Several hematologic disorders are linked to hepatitis C virus infection. "More than 4 million people in the United States are infected with hepatitis C virus (HCV). During the next 20-30 years, the...

Stem cell therapy is a safe tool for mending broken hearts.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- A group of researchers from Rio de Janeiro, Brazil, has shown that stem cell injections by catheters into diseased hearts are feasible and safe, even for very sick patients. The results also...

New data confirms safety of Lipitor in combination with anti-blood-clotting drug.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- Results of a new study showed that patients taking Lipitor (atorvastatin calcium), when used in combination with clopidogrel bisulfate, an anti-blood-clotting agent, experienced equal blood-clotting...

C1 inhibitor benefits sepsis due to lowering of neutrophil activation.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- The treatment of sepsis patients with C1 inhibitor lowers EA, complement, and IL-8 and thus neutrophil activation. According to a study from Switzerland, "Forty patients with severe sepsis or...

FDA clears VIDAS D-Dimer New.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- bioMerieux, Inc. has received clearance from the U.S. Food and Drug Administration (FDA) for its VIDAS D-Dimer New extended range D-dimer assay to exclude the presence of suspected deep vein thrombosis...

NS1 serotype specific IgG ELISA distinguishes primary, secondary infection.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- NS1 serotype specific IgG ELISA can distinguish primary and secondary dengue virus infection, if serum is taken at disease onset, because secondary IgG is not made immediately. According to recent...

Toxoplasma gondii ELISA can give false-positive IgM due to sphingolipids.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- Toxoplasma gondii ELISA can have unspecific IgM reactivity that corresponds with sphingolipids or ceramides found in pathogen, but not due to infection, in pregnant or grafted patients. "During a...

Grant awarded to develop hepatitis C virus drug susceptibility assay.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- ViroLogic, Inc. (VLGC) has been awarded a grant from the U.S. National Institute of Allergy and Infectious Diseases (NIAID), a division of the U.S. National Institutes of Health, to develop a hepatitis...

Lengthened targeting arms do not increase HR efficiency in stem-cell beta-globin locus.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- Lengthened targeting arms do not increase HR efficiency in stem-cell beta-globin loci. "The correction of mutant beta-globin genes has long been a therapeutic goal for patients with beta-thalassemia...

Expression of the novel gene asrij overlaps with vascular markers.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- Expression of the novel gene asrij overlaps with vascular markers. "We have identified a novel gene expressed in murine embryonic stem (ES) cells and in a restricted, tissue-specific pattern during...

Programmed death-1 is involved in protection from GVHD lethality.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- Graft-versus-host (GVHD) disease lethality may be reduced by enhancing programmed death-1, as blockade accelerates GVHD. According to recent research published in the Journal of Immunology, "Acute...

Disease development can be monitored and predicted.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- People with HIV and their physicians could have a less expensive tool to track the progression from HIV infection to AIDS. According to researchers from the Johns Hopkins Bloomberg School of Public...

Stem-cell company provides cardiac risk assessment calculator.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- Heart attacks generally don't provide telltale signals before they occur, so it is vital to assess risk as early as possible. Now, getting that potentially life-saving information is just a click...

Researchers describe stem-cell therapy for myocardial repair, regeneration.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- Heart attack and the resulting heart failure is still one of the leading causes of death in the Western world. Therefore, new therapeutic approaches to restore damaged heart tissue are indispensable....

Cytotoxic T lymphocytes can be generated ex vivo to target multiple myeloma.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- Cytotoxic T lymphocytes can be generated ex vivo to target multiple myeloma. According to a study from the United States, "multiple myeloma (MM) is an incurable plasma cell malignancy characterized...

Negative selection augments the characterization of bone marrow derivatives.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- Negative selection augments the characterization of bone marrow derivatives. "Mesenchymal stem cells (MSCs) are typically enriched from bone marrow via isolation of the plastic adherent,...

Platelet populations become different after abdominal uterine removal.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- Platelet populations become different after abdominal uterine removal. "This study was designed to clarify the quantitative relationship between platelet aggregation and the secretion of adenosine...

89 Killer immunoglobin-like receptor alleles (KIR) have been sequenced.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- 89 Killer immunoglobin-like receptor alleles have been sequenced and translated to date. "We have compiled the nucleotide sequences and their amino acid translations from a total of 89 Killer...

Divergent virology can affect the outcome of ex vivo T-cell expansion.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- Divergent virology can affect the outcome of ex vivo T-cell expansion. "To modulate alloreactivity after hematopoietic stem-cell transplantation, 'suicide' gene-modified donor T cells (GMCs) have...

Arsenic trioxide is effective against acute promyelocytic leukemia.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- Arsenic trioxide is effective against acute promyelocytic leukemia. "Acute promyelocytic leukemia (APL) is now the most potentially curable subtype of acute myeloid leukemia in adults because of...

Flavonoids can differentially modulate the efficacy of chemotherapeutics.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- Flavonoids can differentially modulate the efficacy of chemotherapeutics. "We studied the ability of five structurally related flavonoids (quercetin (QU), luteolin (LU), apigenin (AP), galangin...

Researchers validate the Hammersmith prognostic scoring system.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- Researchers validate the Hammersmith prognostic scoring system. According to a study from England, "We assessed clinical results in 145 patients with chronic myeloid leukemia in chronic phase who...

Vigorous studies required for understanding, management of NK leukemia, lymphoma.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- Vigorous studies required for understanding, management of NK leukemia, lymphoma. According to a study from Japan, "Natural killer (NK) cells are lymphocytes with a large granular lymphocyte...

Allogeneic SCT superior to autotransplantation for young leukemia patients.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- Allogeneic SCT is superior to autotransplantation for the treatment of young leukemia patients. "In the European Organization for Research and Treatment of Cancer Leukemia Group and Gruppo Italiano...

Chromosome 9 inversion linked to poor stem-cell transplantation outcome.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- Leukemia patients with the chromosomal abnormality inv(9) may be poor candidates for stem-cell transplantation. Previous reseach revealed "delayed engraftment after autologous and allogeneic...

Cutaneous T- and B-cell lymphoma need subclassification, specific treatment.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- Cutaneous T- and B-cell lymphoma need subclassification before specific treatment for that type, for optimal results. "Primary cutaneous T- and B-cell lymphomas are a heterogenous group of diseases...

Global patient organization launched to help millions with lymphoma.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- A new alliance has been launched to provide global support to the millions of people living with lymphoma - the most common blood cancer and the third most common cancer of childhood. The Lymphoma...

CD80+ B-cell levels may predict melanoma outcome.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- Circulating levels of CD80+ B cells may help predict the outcome of melanoma treatment. Scientists in Spain conducted a study to "evaluate whether the number of circulating lymphocytes expressing...

Positive, long-term, follow-up data reported from phase I trial of GVAX.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- Cell Genesys, Inc., (CEGE) reported long-term follow-up data from a phase I clinical trial of GVAX melanoma vaccine, a patient-specific vaccine made directly from patient tumor biopsies. Data from...

Company discusses GenSci merger and announces plans to streamline.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- IsoTis, S.A., (ISON) and GenSci Regeneration Sciences, Inc., announced the publication and mailing of the joint information circular (IC) in connection with the intended merger of IsoTis with GenSci...

Multiple myeloma patients may appear to have hyperphosphatemia due to artifact.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- Multiple myeloma patients may appear to have hyperphosphatemia, but this is a sample preparation artifact. "We report the case of a patient with IgG multiple myeloma and pseudohyperphosphatemia....

Ochratoxin A and some metabolites alter kidney cell surface marker expression.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- Mycotoxin ochratoxin A and metabolites alter expression of cell surface markers on kidney cells and even low concentrations could be involved in pathogenesis. "The modulations of...

Myelodysplastic syndrome may occur after acute promyelocytic leukemia.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- Myelodysplastic syndrome may occur after acute promyelocytic leukemia. According to a study from France, "With improved treatment of acute promyelocytic leukemia (APL) by all transretinoic acid...

Philadelphia chromosome may be involved in bone marrow suppression.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- Philadelphia chromosome may be involved in bone marrow suppression. According to published research from Japan, "We describe a patient who presented with aplastic anemia associated with the...

Plasmablastic transformation and acute leukemia can result from multiple myeloma.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- Disease progression in multiple myeloma may even involve plasmablastic transformation and acute leukemia. "We describe morphological, immunophenotypic, and cytogenetic characterization of a case of...

Cerebral microvessel reactions vary in response to focal ischemia.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- Cerebral microvessel reactions vary in response to focal ischemia. According to a study from the United States, "cerebral microvessels have a unique ultrastructure form, which allows for the close...

Combined rituximab and G-CSF treatment yields long remission times.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- Combined rituximab and G-CSF treatment yields long remission times in non-Hodgkin lymphoma. According to recent research published in the journal Leukemia, "Antibody-dependent cellular cytotoxicity...

Listeria moncytogenes cross-contaminates infants in a newborn nursery.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- Listeria moncytogenes cross-contaminates infants in a newborn nursery. "Molecular evidence of Listeria monocytogenes cross-contamination in a nursery is presented. Listeria monocytogenes serotype...

Several factors combine in late pregnancy to increase hemolytic uremic syndrome.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- Several factors combine in late pregnancy to increase hemolytic uremic syndrome. "Thrombotic thrombocytopenic purpura-hemolytic uremic syndrome occurs more commonly in women and among women is...

Mitchell Seyedin, PhD, named president and CEO of tissue-repair company.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- Isto Technologies, Inc., announced the appointment of Mitchell Seyedin, PhD, to succeed Joseph Feder, PhD, as president and CEO. Feder, who served in this position since cofounding Isto...

PolyHeme maker names Eva C. Essig VP regulatory affairs.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- Northfield Laboratories, Inc., (NFLD) announced that Eva C. Essig, PhD, will join the company as vice president of regulatory affairs. Essig brings more than 12 years of regulatory experience to her...

Monocytes starved of glutamine during infection can't degrade all proteins.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- Monocytes in the blood utilize glutamine; starvation of glutamine during infection inhibits some protein degradation and may lead to immune dysfunction. "Peripheral blood monocytes utilize free...

Structure dictates Hsp90 role in heme activator protein Hap1 activation.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- Structural environment dictates the biological significance of heme-responsive motifs and the role of Hsp90 in the activation of the heme activator protein Hap1. According to a study from the...

Slovenian hemodialysis patients experience low viral hepatitis rates.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- Slovenian hemodialysis patients experience low viral hepatitis rates. According to a study from Slovenia, "the total number of end-stage renal failure patients treated by renal replacement therapy...

LepB gene for signal peptidase is similar in R. rickettsii, R. typhi.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- The lepB gene in the agents for Rocky Mountain spotted fever and murine typhus are similar with conserved areas to do with signal peptidase I functional activity. According to a study from the...

Alliance with NIH, USARMID targets discovery of therapeutics against SARS.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- Aphios Corporation has executed a cooperative agreement with the National Institute of Allergy and Infectious Diseases (NIAID), U.S. National Institutes of Health (NIH) and the U.S. Army Medical...

Patient enrollment completed for phase II ICA-17043 trial.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- Icagen, Inc., a privately held biopharmaceutical company focused on ion channel drug discovery and development, announced completion of enrollment in its phase II clinical trial of ICA-17043 for the...

Hemoxin issued orphan drug status by U.S. FDA.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- Xechem International, Inc., (XKEM) received orphan drug designation from the U.S. Food and Drug Administration (FDA), Office of Orphan Drug Products Development, for Niprisan (hemoxin), the...

A novel technique enhances embryonic and neuronal stem-cell labeling.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- A novel technique enhances embryonic and neuronal stem-cell labeling. "Recent developments in stem-cell and gene therapy will require methods to monitor stem-cell survival and integration repeatedly...

CD184 and alpha4beta1 integrins mediate CD34+ cell pseudoemperipolesis.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- CD184 and alpha4beta1 integrins mediate CD34+ cell pseudoemperipolesis. "Marrow stromal cells play an important role in regulating the development and proliferation of hematopoietic stem cells (HSC)...

Hematopoietic cell Hmgb3 expression prevents myeloid and B-cell differentiation.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- Hmgb3 expression by hematopoietic cells prevents them from becoming myeloid cells or B-cells. According to scientists in Washington, DC, "Hmgb3 is a member of a family of chromatin-binding proteins...

Inhibition of p21 expression can aid hematopoietic cell expansion.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- Inhibition of p21 expression can enhance hematopoietic cell expansion. "Relative quiescence is a defining characteristic of hematopoietic stem cells," scientists at Harvard University explained....

Mobilized HSCs later return to marrow.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- Mobilized hematopoietic cells eventually make their way back to their bone marrow home. In a recent study, scientists at the University of Washington "created parabiotic mice, joining ROSA26 and...

Novel EGFP reporter mouse line useful for hematopoietic cell study.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- A novel strain of enhanced green fluorescent protein (EGFP)-expressing reported mice may aid the study of hematopoietic stem cells. "Conditional activation and inactivation of genes using the...

Somatic nucleus reprogramming may be feasible.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- "Reprogramming" of protozoan nuclei may provide a source of customizable cells for therapeutic use. "Somatic nuclei can be epigenetically reprogrammed by factors present in undifferentiated...

Antithymocyte globulin improves outcome for unrelated stem-cell transplantation.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- Antithymocyte globulin (ATG) treatment lower the risk of GvHD and graft failure in recipients of unrelated stem-cell grafts. "Matched unrelated donor transplants have an increased risk of severe...

Beta-blockers may ameliorate GAVE in SCT recipients.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- Beta-blocker therapy may ameliorate gastric antral vascular ectasia (GAVE) in stem-cell transplant recipients. GAVE "may occur after hematopoietic stem-cell transplantation (HSCT) and cause severe...

N-acetyl-L-cysteine does not affect busulfan pharmacokinetics.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- NAC treatment to prevent VOD in stem-cell graft recipients does not affect busulfan pharmacokinetics "Busulfan is currently used as a main component in the conditioning regimen prior to allogeneic...

Serial cytokine monitoring can help identify GVHD patients.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- Serial cytokine monitoring may enable rapid detection of graft-versu-host reactions in SCT recipients. "Tumor necrosis factor-alpha (TNF-alpha) has been implicated in the immunological...

Serum stem-cell growth factor levels useful for monitoring post-SCT recovery.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- Serum levels of stem-cell growth factor (SCGF) can be used to monitor hematopoietic recovery after stem-cell transplantation. SCGF "is a novel cytokine for primitive hematopoietic progenitor...

Safety syringe company to apply for OTC Bulletin Board.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- Maxxon, Inc., (MXON) announced that the U.S. Securities and Exchange Commission has completed its comment and review period for Maxxon's Form 10-SB. The company, whose common stock is currently...

Toxic shock syndrome may be treatable with IVIG therapy.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- Toxic shock syndrome may be treatable with IVIG therapy; mortality and organ failure were greatly reduced. "The efficacy and safety of high-dose intravenous polyspecific immunoglobulin G (IVIG) as...

Immunoliposomes can reduce hemorrhage risk after tPA treatment for stroke.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- Antiactin-targeted immunoliposomes can reduce the risk of hemorrhaging after stroke treatment. "Thrombolytic stroke therapy with tissue plasminogen activator (tPA) is limited by serious risks of...

Anti-SOD autoantibodies may allow damage by radicals in SLE.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- Anti-superoxide dismutase antibodies are partly responsible for damage by radicals in systemic lupus erythematosus. "Free radicals and damage caused by these molecular species are implicated in the...

TCR signal strength controls GATA-3 levels, regulating T-cell differentiation.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- The strength of TCR signal induces differential expression of GATA-3, it in turn regulates CD4/CD8 differentiation. "GATA-3 is expressed at higher levels in CD4 than in CD8 SP thymocytes. Here we...

TSS toxin-1 has a novel domain of the SAG molecule that binds MHC-II.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- Toxic shock syndrome toxin-1 has a domain that binds MHCII that is different than other superantigens, in a new region of the molecule. According to a study from the United States, "Superantigens...

M-T7 protein from myxoma virus may attenuate transplanted kidney rejection.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- In animal models, the M-T7 protein from myxoma virus that alters human chemokines was found to attenuate transplanted kidney rejection. According to recent research published in the journal...

Pregnancy outcome is good following functionally stable kidney transplants.
October 2, 2003... 2003 OCT 2 - (NewsRx.com & NewsRx.net) -- Pregnancy outcome is good following functionally stable kidney transplants; most maternal kidneys survive well, too. "Pregnancy is not contraindicated in renal transplant recipients with stable...