Blood Weekly articles from November 2003

Blood Weekly archives from November 2003

Novel cell line selectively deplete alloreactive donor T-cells from stem-cell grafts.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- A novel cell line selectively deplete alloreactive donor T-cells from stem-cell grafts. "Poor immune reconstitution after haplo-identical stem cell transplantation results in a high mortality from...

Modified human hemoglobin enables targeted oxygen delivery.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- A modified form of human hemoglobin shows promise for targeted oxygen delivery. "To assess O[subscript]2 delivery to tissue by a new surface-modified, polyethylene glycol-conjugated human hemoglobin...

Imatinib suppresses marrow cell monocyte/macrophage differentiation.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- Imatinib suppresses marrow cell monocyte/macrophage differentiation. "The antileukemic tyrosine kinase inhibitor, imatinib, has been reported to inhibit specifically the growth of bcr-abl expressing...

Low-dose short-course ganciclovir effective as post-SCT CMV prophylaxis.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- Limited ganciclovir regimens are safe and effective for CMV prophylaxis in stem cell graft recipients. According to scientists in St. Louis, "In contrast to allogeneic bone marrow transplantation...

SCT conditioning doesn't affect post-transplant CMV risk.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- The type of conditioning used prior to stem-cell transplantation does not affect the risk of post-transplant CMV infection. "Since the incidence of cytomegalovirus (CMV) infections after...

Stem-cell donation by Crohn colitis patients may put recipients at risk.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- Stem-cell donation by Crohn colitis patients may pass the disorder to graft recipients. In the journal Gut, scientists in England described "a case of fulminant Crohn's colitis that occurred...

Cell infusions boost heart function, revive damaged heart muscle.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- Infusing a patient's own cells into a heart artery several days after a heart attack speeds the healing process and strengthens the heart's pumping power, researchers report. In a small study of...

Liver transplant tacrolimus neurotoxicity may be preceded by leukoencephalopathy.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- Liver transplant neurotoxicity following tacrolimus may be preceded by leukoencephalopathy. According to recent research published in the journal Liver Transplantation, "Neurotoxicity is a...

Families with periodontitis have elevated levels of IgG2 that are inherited.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- Families with aggressive periodontitis are found to have elevated levels of IgG2 that are inherited. According to a study from the United States, "IgG2 is elevated in localized but not in...

Erythropoietin treatment could worsen cancer prognosis.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- Results of a European study cast doubt over the value of treating anemia with erythropoietin (epoetin beta) among patients who have cancer. Results of the study show that anemic patients fare better in...

No association found between serum hepcidin and markers of anemia.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- No significant association exists between serum hepcidin and other markers of iron status or anemia. "The hepatic antimicrobial protein, hepcidin, is implicated in duodenal iron absorption and...

IL-17 alone may enhance osteosarcoma cell lysis by natural killer cells.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- Osteosarcoma cells have receptors to IL-17; IL-17 alone may enhance lysis by NK cells, but with IFNgamma they resist NK more. "We investigated the effect of the proinflammatory cytokine interleukin...

On-X prosthetic heart valve maker begins aspirin study.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- Medical Carbon Research Institute, L.L.C., (MCRI), manufacturer of the On-X prosthetic heart valve, announced the initiation of a clinical study under an aspirin-only anticoagulation protocol. The...

Catheter insertion site can make a difference for apheresis patients.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- The site of insertion and other aspects concerning catheters can make a difference for apheresis patients. According to published research from Germany, "In the intensive care unit, apheresis...

Excess vascular endothelial growth factor associates with hyperhomocysteinemia.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- Excess vascular endothelial growth factor associates with hyperhomocysteinemia. "Hyperhomocysteinemia has been reported to be an independent risk factor for atherosclerosis and atherothrombosis....

B7-H3 may be a negative Th1 regulator and may prevent some autoantibodies.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- B7-H3 is involved in downregulation of Th1 responses and lack of it can produce more autoantibodies, experimentally. "We investigated the in vivo function of the B7 family member B7-H3 (also known...

AID may not need cofactors in somatic hypermutation, but may in class-switch.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- Activation-induced cytidine deaminase does not appear to need cofactors in B-cell somatic hypermutation signalling but may need them in class switch. "Activation-induced cytidine deaminase (AID) is...

Fas can induce apoptosis in B cells, but other surface receptors may intervene.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- Fas can induce apoptosis in B cells, but other surface receptors determine to susceptibility to it, unlike other cells. "Engagement of the cell surface receptor Fas/APO-1 (CD95) initiates a...

Glass membranes used to seperate fibronectin from human plasma.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- A novel technique filtering technique enables the seperation of fibronectin from human plasma. In a recent study from the United States, "Macroporous glass membranes were prepared from glass fiber...

Brucellosis patient sera reacts to aminopeptidase N purified from Brucella.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- Acute and chronic brucellosis patient sera reacts to an aminopeptidase N purified from Brucella. According to a study from Mexico, "An immunogenic aminopeptidase was purified from Brucella...

Hormonal factors associate with the risk for Hodgkin disease in women.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- Hormonal factors associate with the risk for Hodgkin disease in women. "Reproductive factors have been suggested to have an impact on the development of Hodgkin disease (HD) in women. In the San...

Anticoagulants could target the angiogenic properties of blood factors.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- Anticoagulants could target the angiogenic properties of blood factors. "In addition to its primary role in hemostasis and blood coagulation, thrombin is a potent mitogen capable of inducing...

Molecular test measures extent of remission, potential for relapse.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- An international consortium of researchers reported the first use of a sensitive molecular test to measure the precise extent of remission or the likelihood of relapse in cancer patients being treated...

"Birthing partners" for stem cells described.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- Blood-forming stem cells may not enter this world alone. They may have birthing partners - cells that live in bone marrow - with which they interact. The research, reported in two papers in Nature,...

NIH grant to be used for development of stem cell treatment.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- Aastrom Biosciences, Inc., (ASTM) announced that it has received a $100,000 Phase I Small Business Innovation Research grant from the U.S. National Institutes of Health (NIH) to develop a bone marrow...

Fibrin polymerization rate in antiphospholipid syndrome plus SLE may be a risk.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- Patients with antiphospholipid syndrome plus lupus have an increased fibrin polymerization rate that may be a clotting risk. "The main event in blood coagulation is the thrombin-catalyzed...

Ischemic colitis patients have lower protein Z, thus risk hypercoagulability.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- Patients with ischemic colitis have a higher risk of clotting complications than diverticulitis patients or normal controls, due to lower plasma protein Z. "Hypercoagulable states have been...

Gene mutation responsible for inflammation identified.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- A mutation in one of the genes that might be responsible for the inflammation that characterizes Crohn disease has been identified by researchers at Temple University's School of Medicine (TUSM). ...

MIT engineers report new approach to tissue engineering.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- Massachusetts Institute of Technology (MIT) engineers report a new approach to creating three-dimensional samples of human tissue that could push researchers closer to their ultimate goal: tissues for...

Adult regulatory genes active during early Hydra embryogenesis.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- Adult regulatory genes are active during early Hydra embryogenesis. "Hydra is a classical model to study key features of embryogenesis such as axial patterning and stem cell differentiation,"...

EBV mononucleosis with thrombocytopenia can have anti-platelet autoantibodies.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- EBV mononucleosis can cause immune thrombocytopenia, with autoantibodies to platelet glycoproteins present. "In this study, we detected autoantibodies to platelet glycoproteins GPIIb/IIIa and...

Drug's price stirs debate.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- Last winter and spring, five Oregon Health & Science University (OHSU) patients used $1.9 million worth of NovoSeven, a $5000-a-dose drug that can stop massive bleeding in minutes. Facing budget...

Non-TBI conditioning reduces SCT toxicity in Fanconi anemia patients.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- Conditioning without radiation reduces toxicity after stem-cell transplantation for Fanconi anemia (FA). According to scientists in England, allogeneic SCT "is the only curative option for severe...

SLUG gene deletion can cause piebaldism.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- SLUG gene deletions can cause piebaldism in humans. "Slug is a zinc-finger neural crest transcription factor, encoded by the SLUG gene, which is critical for development of hematopoietic stem...

Factor V Leiden mutation does not correlate with stillbirth risk.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- Factor V Leiden mutation does not correlate with stillbirth risk. According to published research from Germany, "an association between the factor V Leiden variant and an increased risk of pregnancy...

Syngeneic bone marrow transplant patients do have graft-versus-host disease risk.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- Syngeneic bone marrow transplant patients can get a graft-versus-host disease type syndrome. According to a study from the United States, "Rappeport first reported the clinical syndrome of...

Real-time PCR best choice for CMV monitoring in ATL patients.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- Real-time polymerase chain reaction (PCR) assays are the best choice for CMV monitoring in ATL patients. In a recent study, scientists in Japan "analyzed the efficiency of the quantitative...

Clinical significance of gene defects in coagulation disorder reviewed.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- A researcher has reviewed the clinical significance of gene diagnosis for defects in coagulation factors and inhibitors. According to a study from Austria, "cDNA sequences of all known coagulation...

Dextran-grafted branched polyethylenimine improves gene vector stability.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- Dextran-grafted branched polyethylenimine improves gene vector stability. "In vivo instability of a polycationic vector limits its efficacy after systemic administration. Conjugation of hydrophilic...

Haptoglobin-hemoglobin complex-specific Fab antibody blocks binding to CD163.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- A haptoglobin-hemoglobin complex-specific Fab antibody was capable of blocking the binding of the complex to CD163. "During intravascular hemolysis, hemoglobin (Hb) binds to haptoglobin (Hp)...

Nitridergic platelet pathway activated by hementerin.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- The nitridergic platelet pathway is activated by hementerin, a metalloprotease from the leech Haementeria depressa. According to published research from Brazil, "Hementerin (HT) is an 80-kDa...

Steroid resistant HCV-related autoimmune disorders respond to alternate therapy.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- Steroid resistant HCV-related autoimmune disorders respond to alternate therapy. "We report two cases of hepatitis C virus (HCV) associated autoimmune hematological disorders successfully treated...

Factor VIII gene therapy has produced positive results in a phase 1 trial.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- Factor VIII gene therapy has produced positive results in a phase 1 trial. "In a phase 1 dose escalation study, 13 subjects with hemophilia A received by peripheral intravenous infusion a retroviral...

Hepatitis C-positive grafts are useful for orthotopic liver transplantations.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- Hepatitis C-positive grafts are useful for orthotopic liver transplantations. According to recent research from the United States, "hepatitis C (HCV)-positive liver grafts have been increasingly...

Pharmaceutical company files for GM-CSF approval in Canada.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- Cangene Corporation (CNJ) announced that it has filed a Canadian New Drug Submission for Leucotropin, a protein known as GM-CSF. The submission seeks approval from the Biologics and Genetic...

The HTLV-1 virus depends on TAXREB803 for Tax gene transactivation.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- The HTLV-1 virus depends on TAXREB803 for Tax gene transactivation. "Expression of the human T cell lymphotropic virus type 1 (HTLV-1) genes is transcriptionally activated by the cognate oncoprotein...

Orphan drug status granted for OGP.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- The Committee for Orphan Medicinal Products (COMP) adopted a positive opinion on the designation of the product OGP (10-14)L (H-Tyrosine-Glycine-Phenilalanine-Glycine-Glycine-OH) as an orphan drug for...

Thrombocytopenia non-responsive to splenectomy has T-cell clonal expansion.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- Immune thrombocytopenia patients treated by splenectomy can respond or not; nonresponders have clonal expansion of T-cell receptors with VB3 and VB15. "In recent years, a pathophysiological role...

HBV immune globulin and lamivudine stop viral recurrence after liver graft.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- HBV immune globulin and lamivudine stop viral recurrence after liver graft. According to a study from Spain, "antiviral prophylaxis with lamivudine appears to reduce hepatitis B virus (HBV)...

Insight into mechanism of cladribine is crucial for its optimal use.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- Insight into the mechanism of action and resistance to cladribine is crucial for its optimal use. "The inherent or acquired resistance of leukemic cells to cytostatic agents is a major clinical...

Presence of ALL1/AF4 or BCR/ABL fusion genes linked to poor ALL outcome.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- "To elucidate the biologic and clinical heterogeneity of adult pro-B acute lymphoblastic leukemia (ALL) (ie, terminal deoxynucletidyl-transferase-positive[TdT(+)], CD19(+), CD10(-), surface...

Small and large cells differ molecularly in patients with CLL.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- Small and large cells differ molecularly in patients with chronic lymphocytic leukemia (CLL). "The genetic events involved in the transformation of chronic lymphocytic leukemia (CLL) to Richter's...

Smaller hepatocellular carcinoma lesions improve survival after transplantation.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- Smaller hepatocellular carcinoma lesions improve survival after transplantation. According to a study from Spain, "a consecutive series of 88 patients underwent transplantation for hepatocellular...

Mast cell beta tryptase levels do not change following liver reperfusion.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- Liver transplant complications appear not to be due to reperfusion activation of mast cells; beta tryptase, released in degranulation, does not change. According to a study from the United States,...

Hemophagocytic lymphohistiocytosis symptoms may be caused by high IP-10, MIG.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- Hemophagocytic lymphohistiocytosis symptoms may be caused by high levels of macrophage produced IP-10 and MIG. "We measured serum interferon-gamma-inducible protein 10 (IP-10) and monokine induced...

Global Med Technologies and Keane announce strategic alliance.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- Wyndgate Technologies, a division of Global Med Technologies, Inc., (GLOB), announced a strategic marketing agreement with the healthcare-solutions division of Keane, Inc., (KEA) to provide Wyndgate's...

Tl-201 chloride scintigraphy may be superior in diagnosing multiple myeloma.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- Tl-201 chloride scintigraphy may be superior in diagnosing multiple myeloma. "The objectives of this study were to investigate the role of whole-body Tl-201-chloride scintigraphy in comparison with...

NIH, MDA announce three top research centers.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- The U.S. National Institutes of Health (NIH) and the Muscular Dystrophy Association (MDA) have announced the creation of three "centers of excellence" for muscular dystrophy research. The...

Stem-cell transplantation effective for pediatric MDS patients with monosomy 7.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- Stem-cell grafts are an effective means of treating pediatric myelodysplastic syndrome (MDS), especially in children with monosomy 7. According to published research from Germany, MDS "without an...

Effects of all-trans retinoic acid (ATRA) on human myeloma cells presented.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- Effects of all-trans retinoic acid (ATRA) on human myeloma cells are presented. According to a study from Japan, "All-trans retinoic acid (ATRA) is a natural oxidative metabolite of vitamin A...

Fixed-dose pegfilgrastim allows neutrophil recovery in patients with NHL.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- Fixed-dose pegfilgrastim allows neutrophil recovery in patients with NHL. "Twenty-nine patients with non-Hodgkin's lymphoma received a single subcutaneous injection of 6 mg pegfilgrastim...

Serum CA-125 is a prognostic factor in non-Hodgkin lymphoma.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- Serum CA 125 is a prognostic factor in non-Hodgkin lymphoma. "Cancer antigen 125 (CA 125) is a glycoprotein expressed in normal tissues originally derived from coelomic epithelia such as...

Clinicians need to recognize prematurity risk in pregnant dialysis patients.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- Clinicians need to recognize prematurity risk in pregnant dialysis patients. According to a study from the United States, "current guidelines for dialysis in pregnant women have been developed in...

Fetal thrombophilic mutations are linked to intrauterine growth retardation.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- Fetal thrombophilic mutations are linked to intrauterine growth retardation. "This study was conducted to investigate the association of maternal and/or fetal factor V Leiden (FVL) and G20210A...

Pregnant women with chronic kidney disease should start dialysis sooner.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- Pregnant women with chronic kidney disease should start dialysis sooner. "Pregnancy occurs uncommonly in women with chronic kidney disease (CKD) and fetal outcome tends to be poor, with high rates...

Leishmania binds red blood cells after antibody, complement.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- Leishmania promastigotes become antibody-bound and activate the complement system, but also adhere to erythrocytes. According to a study from Spain, "In human blood, promastigotes bind natural...

Enterocolitis of pseudomembranous or neutropenic origin must be identified early.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- Pediatric cancer patients with pseudomembranous or neutropenic enterocolitis must be distinguished early on for best therapy and results. According to published research from Netherlands,...

Early vaginal bleeding may be due to Rh-, ectopic, or miscarried pregnancy.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- Early vaginal bleeding in pregnancy requires intervention; it is most likely a sign of ectopic pregnancy, miscarriage, or an Rh-negative maternal complication. "The first and foremost diagnosis to...

Chicago to use LinksPoint VectorWatch to identify West Nile virus activity.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- LinksPoint announced that the Chicago (Illinois) Department of Public Health (CDPH) has begun utilizing its LinksPoint VectorWatch geographic risk-modeling system to aid in the prevention of West Nile...

Plasma osmolality is an important element of respiratory adaptations in women.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- Plasma osmolality is an important element of respiratory adaptations in women. "This study tested the hypothesis that plasma osmolality and the strong ion difference [SID] predict PaCO[subscript]2...

Scientists discover cause of leukemia that halted treatment trial for X-SCID.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- U.K. Medical Research Council (MRC) scientists have helped establish the cause of the leukemia that developed in two young patients taking part in a pioneering gene therapy trial to treat the fatal...

CTL in vitiligo patients react to gp100, not MelanA/MART-1 or tyrosinase.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- Of melanocyte antigens gp100, MelanA/MART-1, and tyrosinase, only gp100 stimulated cytotoxic T lymphocyte reactivity in vitiligo patients. According to recent research published in the Journal of...

Umbilical cord blood storage systems sell in Taiwan and Korea.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- ThermoGenesis Corp. announced that the company received orders for three BioArchive Systems from Taiwan and Korea. Kevin Simpson, president and chief operating officer of ThermoGenesis Corp....

Sonic hedgehog needed for neural progenitor cell maintenance in telencephalic niches.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- Sonic hedgehog is needed for neural progenitor cell maintenance in telencephalic stem cell niches. "To directly test the requirement for hedgehog signaling in the telencephalon from early...

A stem cell factor 3'UTR isoform suppresses cotransfected gene expression.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- The SCF 3'UTR can suppress the expression of cotransfected genes. In a recent study from Japan, "One of the isoforms of stem cell factor (SCF) was isolated from an embryonic kidney library with the...

Cord blood cells with lymphoid/NK differentiation capacity identified.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- A novel and rare population of cord blood cells with lymphoid/NK differentiation capacity has been identified. "The hemopoietic stem cell (HSC) compartment encompasses cell subsets with...

Fanconi anemia type C-deficient hematopoietic cells have defective cell cycle control.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- Fanconi anemia type C-deficient hematopoietic cells have defective cell cycle control. "The pathogenesis of bone marrow failure in Fanconi anemia is poorly understood," scientists in the United...

Gene expression by proliferating neural stem cells clarified.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- The patterns of gene expression by proliferating neural stem cells have been clarified. According to published research from the United States, "The genetic programs underlying neural stem cell...

PSGL-1 contributes to E-selectin-mediated progenitor bone marrow homing.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- PSGL-1 contributes to E-selectin-mediated progenitor bone marrow homing. "The nature and exact function of selectin ligands involved in hematopoietic progenitor cell (HPC) homing to the bone marrow...

HSCs home selectively to bone marrow soon after transplantation.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- Donor stem cells are capable of specific homing shortly after transplantation. "Whether hematopoietic stem cells (HSCs) home selectively to bone marrow (BM) early after transplantation remains an...

SCT should be offered early to autosomal recessive osteopetrosis patients.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- Stem-cell transplantation should be used to treat autosomal recessive osteopetrosis, as early as possible. According to published research from the Netherlands, "A retrospective analysis was made...

Stem-cell grafts can be harvested from craniotomy bone flaps.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- Adequate hematopoietic stem-cell grafts can be harvested from craniotomy bone flaps. "Primary brain tumors seldom infiltrate into the cranium, even if they are invasive in the central nervous...

Study finds blood precursors to lupus.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- Researchers have found blood antibodies that can herald the symptoms of lupus years in advance, potentially helping point the way toward future treatments for the life-threatening immune disease. ...

Lack of diacylglycerol kinase in T cells may promote increased immune response.
November 6, 2003... 2003 NOV 6 - (NewsRx.com & NewsRx.net) -- Diacylglycerol kinase zeta in T cells is the molecule regulating diacylglycerol which is involved in length of TCR binding and thus strength of immune response. "Much is known about how T-cell...