Blood Weekly articles from May 2009

Blood Weekly archives from May 2009

Remote or rural residence not associated with increased time to kidney transplantation.
May 7, 2009... Contrary to what may be a common perception, researchers found no evidence that the likelihood of kidney transplantation is lower among remote- or rural-dwelling patients treated for kidney failure in the United States, according to a study in...

'Nature vs. nurture' study of deceased donor pairs in kidney transplantation.(Obituary)
May 7, 2009... The implications of a new study could improve the outcomes, and potentially survival rates, for some of the thousands of individuals who undergo kidney transplants each year. The study concluded that donor-related risk factors, yet to be...

Study findings from K. Petrie et al provide new insights into acute myeloid leukemia.
May 7, 2009... According to recent research published in the journal Current Opinion in Hematology, "Purpose of review Since the 1970s, the concept of differentiation therapy has been viewed as a promising and revolutionary approach for the treatment of acute...

Studies from Shanghai Jiao Tong University have provided new data on acute promyelocytic leukemia.
May 7, 2009... "All-trans retinoic acid (ATRA)/arsenic trioxide (ATO) combination-based therapy has benefitted newly diagnosed acute promyelocytic leukemia (APL) in short-term studies, but the long-term efficacy and safety remained unclear. From April 2001,...

Study results from Children's Hospital update understanding of apoptosis.
May 7, 2009... According to a study from the United States, "Extensive apoptosis of leukocytes during sepsis and endotoxic shock constitutes an important mechanism linked to the excessive mortality associated with these disorders. Caspase inhibitors confer...

Researchers' work from University of Fukui focuses on drug development.
May 7, 2009... According to recent research from Fukui, Japan, "Myelotoxicity, a major toxicity of vinorelbine. may be related to the degree of one's exposure to vinorelbine. In theory, clarithromycin has the potential to alter vinorelbine's pharmacokinetics...

Study findings on endometriosis are outlined in reports from L. Kang and colleagues.
May 7, 2009... In this recently published study, investigators in Shanghai, People's Republic of China conducted a study "To examine the clinical application of laparoscopic partial resection of symptomatic adenomyosis combined with uterine artery Occlusion...

Study results from C. Cordonnier and colleagues in the area of fungal disease published.
May 7, 2009... "Empirical antifungal therapy is the standard of care for neutropenic patients with hematological malignancies who remain febrile despite broad-spectrum antibacterial treatment. Recent diagnostic improvements may ensure the early diagnosis of...

Studies from Kyoto University, Medical Department yield new information about hematologic disease.
May 7, 2009... "The impact of donor-recipient ABO matching on outcomes after allogeneic stem cell transplantation has been a matter of controversy. Individual patient data-based meta-analysis was conducted with a pooled data set provided through six published...

Study data from T. Kawase and colleagues update understanding of hematologic disease.
May 7, 2009... "The finding that the risk of relapse in hematologic malignancy decreases after allogeneic hematopoietic stem cell transplantation (HSCT) has lead to the concept of a graft-versus-leukemia (GVL) effect. However, this beneficial effect is...

Findings in hemophilia reported from E.I.B. Peerschke and co-researchers.
May 7, 2009... According to a study from the United States, "Quantification of inhibitory antibodies against infused factor VIII (FVIII) has an important role in the management of patients with hemophilia A. This article summarizes results from the largest...

Research in the area of insulin resistance reported from T. Grau and colleagues.
May 7, 2009... According to recent research from Madrid, Spain, "Purpose of review Despite increasing evidence that critically ill patients have lower energy requirements than expected, most guidelines continue to recommend elevated caloric requirements in h...

New Klebsiella pneumoniae study results from S.G. Stahlhut et al described.
May 7, 2009... "FimH is an adhesive subunit of type 1 fimbriae expressed by different enterobacterial species. The enteric bacterium Klebsiella pneumoniae is an environmental organism that is also a frequent cause of sepsis, urinary tract infection (UTI), and...

Research on legionnaire disease published by scientists at St. Antonius Hospital.
May 7, 2009... According to recent research from Nieuwegein, Netherlands, "Polymorphisms leading to deficiency of mannose-binding lectin (MBL) are associated with predisposition to infection. However, MBL deficiency can be protective against intracellular...

Findings from M. Goldman et al in life sciences reported.
May 7, 2009... "In August 2005, the Canadian Blood Services decreased the deferral period for tattooing and ear or body piercing from 12 to 6 months. This study assessed the impact of this change on blood safety and availability," scientists in Ottawa, Canada...

New findings from Taipei Veterans General Hospital in the area of life sciences published.
May 7, 2009... According to recent research from Taipei, Taiwan, "A 50-year-old man presented with an asymptomatic, 1.5 x 1.5 cm, dark-brown noduloplaque with a rubbery consistency (Fig. 1) on the lateral aspect of the left lower leg of uncertain duration....

New life sciences study findings recently were published by researchers at Vanderbilt University.
May 7, 2009... "Tuon and colleagues have developed an animal model to examine the impact of sepsis on memory in rats," researchers in the United States report (see also Life Sciences). "They report important data that expand the understanding of the...

Findings in lupus reported from K. Anam and co-researchers.(Report)
May 7, 2009... "Tissue damage associated with a severe injury can result in profound inflammatory responses that may trigger autoimmune development in lupus-prone individuals. In this study, we investigated the role of a large full-thickness cutaneous burn...

Researchers at University of Medicine and Dentistry of New Jersey target lymphangioma.
May 7, 2009... According to recent research from the United States, " Attributed to congenital malformation of lymphatic duets, diffuse retroperitoneal cystic has it distribution that often corresponds to the location. of primitive fetal lymphatic sacs. Three...

Studies from Osaka University, Medical Department in the area of lymphoma described.
May 7, 2009... " Because recognizable lesions are often absent, selection of biopsy sites for diagnosis of intravascular large B-cell lymphoma (IVL) is frequently problematic. A 59-year-old woman was admitted with fever and general fatigue," scientists in...

New myelodysplastic syndrome study findings have been reported by P.K. Eplingburnette and colleagues.
May 7, 2009... According to recent research from the United States, "Purpose of review Myelodysplastic syndrome is an important hematological malignancy affecting the expanding aged population. Our understanding of the biology of this disease has been limited...

Researchers from University of Paris detail new studies and findings in the area of myelodysplastic syndrome.
May 7, 2009... " Drug treatments for patients with high-risk myelodysplastic syndromes provide no survival advantage. In this trial, we aimed to assess the effect of azacitidine on overall survival compared with the three commonest conventional care...

Researchers from University of Paris report details of new studies and findings in the area of myelodysplastic syndrome.
May 7, 2009... According to recent research from Bobigny, France, "Purpose of review Myelodysplastic syndromes (MDS) are characterized by chronic cytopenias and a high risk of transformation to acute myeloid leukemia, To date, only allogeneic stem cell...

Study data from Celgene Corporation update knowledge of myelodysplastic syndrome.(Report)
May 7, 2009... "Multiple myeloma treatment with lenalidomide-based regimens is associated with risk of venous thromboembolism (VTE), particularly during concomitant use with erythropoiesis-stimulating agents (ESAs). The risk of VTE in myelodysplastic syndrome...

New pancreatitis research reported from P.D. Hardt and co-authors.
May 7, 2009... According to a study from Giessen, Germany, "Purpose of review To learn about the prevalence, pathophysiology, and treatment of exocrine pancreatic involvement in critically ill patients. Recent findings Elevations in the levels of pancreatic...

Findings from University of Giessen in sepsis reported.
May 7, 2009... " One of the main causes of death in European and US intensive care units is sepsis. It involves a network of pro-inflammatory cytokines such as TNF-alpha, IL-1 beta and IL-6," investigators in Giessen, Germany report (see also Sepsis). ...

New sepsis findings from E.N. Deal and co-authors described.(Report)
May 7, 2009... According to a study from the United States, "Various dosing strategies for cefepime have been developed in an effort to maximize pharmacodynamic exposure of this agent against gram-negative infections. An assessment of cefepime dosing...

New sepsis research from Emory University discussed.
May 7, 2009... "In the previous issue of Critical Care, Blanco and colleagues contributed to a growing body of literature on the international epidemiology of severe sepsis. Taken together, these studies confirm that the sepsis incidence is high, that the...

New sepsis study results from M. Sanzgarcia et al described.
May 7, 2009... "Patients with recurrent episodes of Escherichia coli bloodstream infection (REC-BSI) have been described previously only in small studies. We report on the incidence, clinical significance, and predisposing conditions of REC-BSI in a general...

Reports from University of Colorado advance knowledge in sepsis.
May 7, 2009... " Septic encephalopathy secondary to a breakdown of the blood-brain barrier (BBB) is a known complication of sepsis. However, its pathophysiology remains unclear," scientists in the United States report (see also Sepsis). "The present...

Reports outline sepsis study findings from University of California.
May 7, 2009... According to recent research from the United States, " Sepsis is the 10th leading cause of death in the United States. The National Center for Health Statistics' multiple-cause-of-death (MCOD) dataset is a large, publicly available,...

Research conducted at Emory University has provided new information about sepsis.
May 7, 2009... " Diabetes mellitus (DM) is one of the most common chronic co-morbid medical conditions in the USA and is frequently present in patients with sepsis. Previous studies reported that people with DM and severe sepsis are less likely to develop...

Research on sepsis published by F. Venet et al.
May 7, 2009... "Sepsis syndrome represents the leading cause of death in intensive care unit. Patients present features consistent with a decline in immune responsiveness potentially contributing to mortality," scientists in Lyon, France report (see also...

Research on sepsis published by scientists at Washington University, Medical Department.(Report)
May 7, 2009... According to recent research from the United States, "Sepsis is a severe, life-threatening infection and a leading cause of death in hospitals. A hallmark of sepsis is the profound apoptosis-induced depletion of lymphocytes generating a...

Researchers from Cooper University provide details of new studies and findings in the area of sepsis.
May 7, 2009... "Current murine models of sepsis do not account for the effects of aggressive fluid resuscitation on hemodynamics and mortality. Evaluate the impact of fluid resuscitation regimens on cardiovascular performance and survival in a murine model of...

Researchers from University of Washington detail new studies and findings in the area of sepsis.
May 7, 2009... According to recent research from the United States, "Sepsis is an important clinical problem with a mortality rate of 20% to 30%." "Lymphocyte apoptosis has been recognized as an important step in the pathogenesis of experimental sepsis,...

Studies from University of Queensland have provided new information about sepsis.(Clinical report)
May 7, 2009... According to a study from Brisbane, Australia, "A lack of published pharmacokinetic data on statins in sepsis has prompted concerns about their safety and toxicity. This study determined single dose pharmacokinetics of Atorvastatin administered...

Studies from University of Texas in the area of sepsis described.
May 7, 2009... According to recent research published in the journal Critical Care, "Impairment of the protein C pathway plays a central role in the pathogenesis of sepsis. Treatment with recombinant human activated protein C (rhAPC) has been reported to...

Study Finds Blood Cells Can Be Reprogrammed to Act as Embryonic Stem Cells.
May 7, 2009... In a recent study, U.S. researchers have reprogrammed cells found in circulating blood into cells that are molecularly and functionally indistinguishable from embryonic stem cells, a revolutionary achievement that provides a readily accessible...

Research from Central South University, Institute of Molecular Hematology reveals new findings on acute promyelocytic leukemia therapy.
May 7, 2009... A new study, 'Use of all-trans retinoic acid in combination with arsenic trioxide for remission induction in patients with newly diagnosed acute promyelocytic leukemia and for consolidation/maintenance in CR patients,' is now available....

New alpha-thalassemia research reported from N. Sardon Estevez and co-authors.
May 7, 2009... New investigation results, 'Diagnostic value of zinc protoporphyrin in a screening strategy for alpha-thalassemia,' are detailed in a study published in European Journal of Haematology. "The definitive diagnosis of alpha-thalassemia involves...

Data from Wayne State University, Department of Pediatrics advance knowledge in epilepsy.(Clinical report)
May 7, 2009... Research findings, 'Role of subdural electrocorticography in prediction of long-term seizure outcome in epilepsy surgery,' are discussed in a new report. "Since prediction of long-term seizure outcome using preoperative diagnostic modalities...

New hematologic disease study findings recently were reported by researchers at Emory University, Winship Cancer Institute.
May 7, 2009... New investigation results, 'Detection of respiratory viruses with a multiplex polymerase chain reaction assay (MultiCode-PLx Respiratory Virus Panel) in patients with hematologic malignancies,' are detailed in a study published in Leukemia &...

Study results from Shinshu University, Department of Pediatrics update understanding of pediatric in children.
May 7, 2009... Investigators publish new data in the report 'High incidence of meropenem resistance among alpha-hemolytic streptococci in children with cancer.' According to recent research published in the journal Pediatrics International, "Infections caused...

Study findings on lymphoma immunology are outlined in reports from Center for Cancer Research.(Report)
May 7, 2009... New research, 'Autoimmunity and hematologic malignancies: associations and mechanisms,' is the subject of a report. According to recent research from the United States, "Although the true prevalence of autoimmune diseases remains to be better...

New myelodysplastic syndrome therapy study findings have been published by scientists at Medical University of Vienna.
May 7, 2009... A report, 'Deferasirox induces regression of iron overload in patients with myelodysplastic syndromes,' is newly published data in European Journal of Clinical Investigation. According to a study from Vienna, Austria, "Transfusion-related...

New neutropenia therapy research reported from University of Texas, M.D. Anderson Cancer Center.
May 7, 2009... A new study, 'The changing face of febrile neutropenia-from monotherapy to moulds to mucositis. Fever and neutropenia: the early years,' is now available. According to a study from the United States, "The importance of neutropenia as a...

Research conducted at University of Pittsburgh, Department of Dermatology has provided new information about purpura.
May 7, 2009... Scientists discuss in 'Periumbilical purpura prior to gastrointestinal involvement in Henoch-Schönlein purpura' new findings in purpura. According to a study from the United States, "Henoch-Schönlein purpura (HSP) is a systemic...

Study findings from Dicle University, Department of Hematology broaden understanding of purpura therapy.(Report)
May 7, 2009... Scientists discuss in 'The efficacy of rituximab in patients with splenectomized refractory chronic idiopathic thrombocythopenic purpura' new findings in purpura. "The most difficult problem a physician encounters is the management of patients...

Scientists at National Heart, Lung, & Blood Institute publish research in sickle cell anemia.(Report)
May 7, 2009... New research, 'Near-infrared spectra absorbance of blood from sickle cell patients and normal individuals,' is the subject of a report. "Limited data are available regarding the physicochemical dynamics of tissue hypoxia in sickle cell disease....

Studies in the area of acute myeloid leukemia reported from J.E. Lancet and co-researchers.
May 7, 2009... According to a study from the United States, "Purpose of review Given the high rates of relapse in acute myeloid leukemia (AML), there is tremendous opportunity for the development of new therapeutic strategies in the postremission state....

New alloimmunization data have been reported by A. Franco and co-authors.
May 7, 2009... According to recent research from the United States, "To determine whether prenatal management using guidelines established for anti-D is applicable to anti-Jka. A computerized database containing the records of all alloimmunized pregnancies at...

New anaphylactic shock study results from J. Chen et al described.
May 7, 2009... "To report a rare but severe adverse effect of intravenous itraconazole, anaphylactic shock with hypotension and hypoxemia, in a female patient with acute lymphoblastic leukemia (ALL). SUMMARY: A 36-year-old woman with ALL received antifungal...

Researchers at Catholic University, Medical Department release new data on angiology.
May 7, 2009... According to a study from Santiago, Chile, "Vascular calcification has been widely recognized as a significant contributor to cardiovascular risk in patients with chronic kidney disease. Recent evidence suggests that BMP-7 decreases the...

Data from J. Minami and colleagues advance knowledge in angiotensins.
May 7, 2009... According to recent research from Mibu, Japan, "Among angiotensin receptor blockers (ARBs), telmisartan is suggested to function as a partial agonist of peroxisome proliferator-activated receptor-gamma (PPAR gamma) and to improve lipid and...

Research on angiotensins described by R.D. Feldman and colleagues.
May 7, 2009... "Notwithstanding the availability of antihypertensive drugs and practice guidelines, blood pressure control remains suboptimal. The complexity of current treatment guidelines may contribute to this problem," investigators in London, Canada...

Researchers from Ehime University, Medical Department report recent findings in angiotensins.
May 7, 2009... "Recently we have cloned angiotensin II type 2 receptor-interacting protein 1 (ATIP1) as a novel protein that interacts specifically with the C-terminal tail of the angiotensin II type 2 receptor; however, the pathophysiological roles of ATIP1...

Researchers from Harvard University detail new studies and findings in the area of angiotensins.
May 7, 2009... According to a study from the United States, "Stennett AK, Qiao X, Falone AE, Koledova VV, Khalil RA. Increased vascular angiotensin type 2 receptor expression and NOS-mediated mechanisms of vascular relaxation in pregnant rats." "Am J...

Investigators at National University have published new data on antimicrobials.
May 7, 2009... "Antimicrobial peptides constitute an important part of the innate immune defense and are promising new candidates for antibiotics. Naturally occurring antimicrobial peptides often possess hemolytic activity and are not suitable as drugs,"...

New apoptosis research from Ruhr University outlined.
May 7, 2009... According to a study from Bochum, Germany, "Meridional rhodium(III) polypyridyl complexes of the type mer-[RhX3(DMSO)(pp)] (X = Cl, pp = phen 1, dpq 2, dppz 3, X = Br, pp = phen 4) represent a promising class of potent cytostatic agents for the...

Research on arteriovenous fistula detailed by J. Chew and co-authors.
May 7, 2009... In this recently published study, investigators in Vancouver, Canada conducted a study "To present our experience with the endovascular management of intracranial dural arteriovenous fistulas with direct cortical venous drainage by...

Study findings on arteritis are outlined in reports from G. Canaud and colleagues.
May 7, 2009... According to a study from Paris, France, "Fungal contamination of kidney allograft preservative fluid can lead to renal arteritis and arterial wall rupture. We have evaluated a conservative management strategy based onearly antifungal therapy,...

Reports outline arthroplasty research from S. Tarasevicius and colleagues.
May 7, 2009... "Background and purpose We have previously reported that the first 10 years of hip arthroplasty in Lithuania resulted in a higher cumulative revision rate than that observed in Sweden. We thus compared the corresponding results after...

Studies conducted at F. Consolo et al on artificial liver recently published.
May 7, 2009... "A comprehensive computational study modelling the operation of a rotating hollow-fiber bioreactor for artificial liver (BAL) was performed to explore the interactions between the oxygenated culture medium and the cultured hepatocytes....

New atherosclerosis study findings have been published by M.C. Guisasola and colleagues.(Report)
May 7, 2009... According to a study from Madrid, Spain, "Atherosclerosis is a disease whose pathogenesis involves inflammatory and immunological mechanisms, including an autoimmune reaction against heat shock proteins (Hsps). The purpose of this study was to...

Scientists at University of Rome discuss research in atherosclerosis.
May 7, 2009... "Detection of early carotid vascular disease in patients with systemic lupus erythematosus (SLE) is considered mandatory for evaluation of subclinical atherosclerosis (ATS), and various ultrasonographic ( US) parameters have been proposed. In...

Research results from City Hospital update knowledge of atrial fibrillation.
May 7, 2009... According to a study from Birmingham, the United Kingdom, "Acute atrial fibrillation (AF) is the most common cardiac rhythm encountered in clinical practice and is commonly seen in acutely ill patients in critical care. In the latter setting,...

Study results from S. Rietbrock and colleagues in the area of atrial fibrillation published.(Report)
May 7, 2009... "The objective of this study was to evaluate the rate of stroke associated with aspirin and warfarin in routine clinical practice. The study included patients aged 40+ with chronic atrial fibrillation (cAF) registered in the UK General Practice...

Reports from Eulji University describe recent advances in autosomal dominant polycystic kidney.
May 7, 2009... According to recent research published in the Journal of Korean Medical Science, "Polycystic liver is the most common extra-renal manifestation associated with autosomal dominant polycystic kidney disease (ADPKD), comprising up to 80% of all...

Researchers from La Trobe University publish new studies and findings in the area of behavior.
May 7, 2009... According to recent research from Australia, "Endocrine responses to fluid deprivation/restoration and preference for ethanol solution vs. water were assessed in sheep maintained for 5 months on a 10% ethanol solution as their sole source of...

Research from B. Hadjkacem and co-researchers yields new findings on Bernard-Soulier syndrome.(Report)
May 7, 2009... According to a study from Sfax, Tunisia, "Bernard-Soulier syndrome (BSS) is a rare autosomal recessive genetic disorder characterized by thrombocytopenia, circulating giant platelets, and prolonged bleeding time. BSS is explained by a defect in...

New biomedicine study findings have been reported from R. Rodriguezesteban et al.
May 7, 2009... According to a study from the United States, "Molecular perturbations provide a powerful toolset for biomedical researchers to scrutinize the contributions of individual molecules in biological systems. Perturbations qualify the context of...

Study results from Queen Elizabeth Hospital in the area of biomedicine published.
May 7, 2009... According to recent research from Birmingham, the United Kingdom, "Liver transplantation is the established treatment for selected patients with acute liver failure or decompensated chronic liver disease. The procedure is not without its risks,...

Data on blood pressure discussed by T. Pramanik and colleagues.(Report)
May 7, 2009... According to recent research published in the Journal of Alternative and Complementary Medicine, "The objective of this study was to evaluate the immediate effect of slow pace bhastrika pranayama (respiratory rate 6/min) for 5 minutes on heart...

New blood pressure study findings have been reported by scientists at University of California.
May 7, 2009... According to recent research from the United States, "A single bout of mild to moderate exercise can lead to a postexercise decrease in blood pressure in hypertensive subjects, namely postexercise hypotension (PEH). The full expression of PEH...

Scientists at Michigan Technological University target blood pressure.
May 7, 2009... "Carter JR, Ray CA. Sympathetic neural responses to mental stress: responders, nonresponders and sex differences," investigators in the United States report (see also Blood Pressure). "Am J Physiol Heart Circ Physiol 296: H847-H853, 2009....

Studies from University of California in the area of blood pressure described.
May 7, 2009... According to a study from the United States, "Both antioxidant supplementation and exercise training have been identified as interventions which may reduce oxidative stress and thus improve cardiovascular health, but the interaction of these...

Studies from University of Leicester in the area of blood pressure described.
May 7, 2009... "Spontaneous fluctuations in BP (blood pressure) and subsequent change in CBFV (cerebral blood flow velocity) in the MCA (middle cerebral artery) can be used to assess dynamic cerebral autoregulation using transfer function analysis; however,...

New bone marrow data have been reported by R.W. Thomason and co-authors.
May 7, 2009... "We recently reported that parenteral iron therapy is associated with a characteristic pattern of iron staining on bone marrow aspirate smears," scientists writing in the American Journal of Clinical Pathology report (see also Bone Marrow). ...

New bone marrow findings from Marche Polytechnic University published.(Report)
May 7, 2009... " Mesenchymal stromal cells (MSC) are promising candidates for cell therapy and tissue engineering and may be used to treat acute graft-versus-host disease (GvHD). However, major obstacles for their clinical use are the required cell dose and...

New bone marrow study results from A. Gobbi et al described.
May 7, 2009... "The anterior cruciate ligament has been shown to have poor healing ability, and reconstruction is the standard treatment. Primary anterior cruciate ligament repair combined with bone marrow stimulation could restore stability and function in...

Research results from University of California update understanding of bone marrow.(Report)
May 7, 2009... "The objectives of our study were to compare image quality of the spine and visualization of spine abnormalities at 3 T and 1.5 T as well as to evaluate differences in quantitative assessment of normal and neoplastic vertebral bone marrow. One...

Studies from INSERM provide new data on bone marrow transplantation.(Report)
May 7, 2009... According to a study from Paris, France, "The tyrosine kinase JAK3 plays a well-established role during normal lymphocyte development and is constitutively phosphorylated in several lymphoid malignancies. However, its contribution to...

New bone research study results reported from G. Bettega et al.(Report)
May 7, 2009... "Autologous platelet (PLT)-rich plasma has been reported in some studies to promote osteogenesis. The goal of this study was to demonstrate that osteogenesis gained by mixing autologous PLT concentrates (APCs) with a small quantity of...