Blood Weekly articles from June 2009

Blood Weekly archives from June 2009

LSUHSC research describes function of key protein in cancer spread.
June 4, 2009... Research led by David Worthylake, PhD, Assistant Professor of Biochemistry and Molecular Biology at LSU Health Sciences Center New Orleans, may help lay the groundwork for the development of a compound to prevent the spread of cancer. The...

Triglycerides implicated in diabetes nerve loss.
June 4, 2009... A common blood test for triglycerides - a well-known cardiovascular disease risk factor - may also for the first time allow doctors to predict which patients with diabetes are more likely to develop the serious, common complication of...

Acute kidney injury common after liver transplantation.
June 4, 2009... Even mild cases of acute kidney injury after liver transplantation are associated with lower survival for both the patient and the graft. With more severe injury, outcomes are even worse. These findings are in the May issue of Liver...

Investigators at Fudan University target acute leukemia.
June 4, 2009... "Myeloid/NK cell leukemia is distinct entity, being different from the myeloid/NK cell precursor acute leukemia and blastic NK cell lymphoma/leukemia in morphology and immunotypes. The entity is a more mature state than the latter," scientists...

Reports summarize acute leukemia research from Kyoto Prefectural University, Medical Department.
June 4, 2009... "Biphenotypic acute leukemia co-expressing T-lymphoid and myeloid markers is rare, accounting for less than 1% of acute leukemias. However, several clinical characteristics including male predominance, frequent lymphadenopathy and unfavorable...

Study results from University of Florida update understanding of gastroenterology.(Report)
June 4, 2009... "Zinc metabolism during chronic disease is dysregulated by inflammatory cytokines. Experiments with IL-6 knockout mice show that LPS regulates expression of the zinc transporter, Zip14, by a mechanism that is partially independent of IL-6,"...

Study results from P. Caprari and colleagues update understanding of hereditary spherocytosis.
June 4, 2009... According to recent research from Rome, Italy, "The implantation of a prosthetic heart valve (HVP) in patients with hereditary spherocytosis (HS) and hereditary elliptocytosis (HE) is rare, and the changes in the structure and deformability of...

New life sciences research reported from H. Mansouritorghabeh and co-authors.
June 4, 2009... According to a study from Iran, "Combined factor V and VIII deficiency (CF5F8D) is a rare autosomal recessive disorder, with an estimated prevalence of about 1:100,000 in the Jewish population. Affected individuals have between 5 and 30% of...

Research on life sciences discussed by E.N. Johnson and co-researchers.
June 4, 2009... In this recently published article, scientists in the United States conducted a study "To date, there have been no published studies describing rates of device-associated infections over extended. periods at deployed military hospitals. We...

Study results from La Sapienza University broaden understanding of life sciences.
June 4, 2009... "Hospital-acquired infections (HAIs) represent an important cause of morbidity and mortality in neonatal intensive care units (NICUs). All neonates admitted for > 48 hours between January 2003 and December 2006 in the NICU of the teaching...

Research on liver transplant discussed by A. Lacasse and co-researchers.
June 4, 2009... "A. Lacasse, K.O. Cleveland. Trichosporon mucoides fungemia in a liver transplant recipient: case report and review.Transpl Infect Dis 2009: 11: 155-159," scientists writing in the journal Transplant Infectious Disease report (see also Liver...

New lymphoblastic lymphoma research has been reported by scientists at University of Athens, Medical Department.
June 4, 2009... "Lymphomas associated with Warthin's tumor (WT) are extremely uncommon and the majorities are of B cell type. We report the simultaneous occurrence of T-cell lymphoblastic lymphoma (T-LBL) and WT in an 81-year-old patient, who presented with...

Research on neutropenia discussed by scientists at State University of New York.
June 4, 2009... According to recent research published in the journal Cancer Chemotherapy and Pharmacology, " Our objective was to build a mechanism-based pharmacodynamic model for the time course of neutropenia in cancer patients following paclitaxel...

Studies from R. Ram et al further understanding of neutropenia.
June 4, 2009... According to a study from Israel, "Monitoring the rate of infections in individual centers that treat patients with hematological malignancies is of major importance. However, there are no uniform guidelines for infection surveillance." ...

New non-small cell lung cancer findings from Shinshu University described.
June 4, 2009... " Our objective was to assess the effcacy and toxicity of concurrent chemoradiotherapy with cisplatin + weekly divided-dose docetaxel in patients with stage III non-small-cell lung cancer (NSCLC). A total of 34 patients aged less than 75 years...

New sepsis research has been reported by scientists at University of Minnesota.
June 4, 2009... "The history of adjunctive treatments for severe sepsis has been fraught with more failures than successes. To date, there have been few interventions that have been demonstrated to be efficacious by multiple large, well-designed, multicenter...

New sepsis research reported from Washington University, Medical Department.
June 4, 2009... According to a study from the United States, "Catheter-related bloodstream infections (CR-BSIs) are a common, frequently preventable complication of central venous catheterization. CR-BSIs can be prevented by strict attention to insertion and...

New sepsis study findings recently were published by researchers at University of Heidelberg.(Report)
June 4, 2009... According to a study from Mannheim, Germany, "Despite a decreased mortality from sepsis, the absolute number of sepsis-related deaths has actually increased during the last years. At present, there are no biological markers available that can...

Recent findings in small cell lung cancer described by researchers from Akita University, Medical Department.(Report)
June 4, 2009... "Small lesions are frequently detected in the lung with computed tomography (CT) in clinical practice. It is important to know the CT features of small-sized periphearal small cell lung cancer (SCLC) for early-stage diagnosis," scientists in...

Research from A.T. Nurden and colleagues has provided new data on thrombocytopenic purpura.
June 4, 2009... According to recent research from Pessac, France, "Idiopathic thrombocytopenic purpura is an acquired disease characterised by a low platelet count. Development of autoantibodies is a main cause of the disease." "Although many patients...

New tuberculosis study findings have been reported from Y.K. Wen et al.
June 4, 2009... "We report a 70-year-old man who presented with cervical lymphadenopathy, hypercalcemia, and acute renal failure. Lymph node biopsy revealed caseating granulomas," scientists writing in the journal Clinical Nephrology report (see also...

Research from Chongqing University of Medical Sciences has provided new data on acute cholangitis immunology.(Report)
June 4, 2009... Research findings, 'Triggering receptor in myeloid cells (TREM-1) specific expression in peripheral blood mononuclear cells of sepsis patients with acute cholangitis,' are discussed in a new report. According to a study from Chongqing, People's...

Studies conducted at M.O. Timsit et al on bladder exstrophy recently published.
June 4, 2009... A report, 'Use of forearm free-flap phalloplasty in bladder exstrophy adults,' is newly published data in Bju International. "To assess the long-term outcome and cosmetic results of forearm free-flap phalloplasty for correcting micropenis...

Research reports on blood substitutes from University of Pretoria provide new insights.
June 4, 2009... A new study, 'Non-toxicity of IV injected perfluorocarbon oxygen carrier in an animal model of liver regeneration following surgical injury,' is now available. According to recent research published in the journal Artificial Cells, Blood...

Study findings from T. Harnois et al provide new insights into blood substitutes.
June 4, 2009... Researchers detail in 'High-level production of recombinant arenicola marina globin chains in Escherichia coli: a new generation of blood substitute,' new data in blood substitutes. "This work reports for the first time the expression of a...

Research on Crohn disease risk factors described by scientists at University of Amsterdam, Department of Surgery.
June 4, 2009... Fresh data on Crohn disease are presented in the report 'Outcome of surgical treatment for fistula in ano in Crohn's disease.' "Recurrence rates and long-term functional outcome after surgical treatment of anal fistula in Crohn's disease were...

Researchers from Chi-Mei Medical Center, Department of Pathology report on findings in large-cell lymphoma.
June 4, 2009... A report, 'Lymphohistiocytic anaplastic large cell lymphoma involving skin: a diagnostic challenge,' is newly published data in Pathology - Research and Practice. "Systemic anaplastic large cell lymphoma (ALCL) involving the skin should be...

Reports from Mugla University add new data to research in life sciences.
June 4, 2009... Current study results from the report, 'Sulfite determination by a biosensor based on bay leaf tissue homogenate: very simple and economical method,' have been published. According to recent research from Mugla, Turkey, "Of all the food...

Research from Ankara University, Department of Chemical Engineering in the area of life sciences described.
June 4, 2009... New investigation results, 'Impact of inoculation strategy on the progress of Candida rugosa cultivation,' are detailed in a study published in Artificial Cells, Blood Substitutes, and Immobilization Biotechnology. "Batch cultivation of Candida...

Studies from University Medical Center have provided new data on life sciences.(Report)
June 4, 2009... A new study, 'Role of p38 and early growth response factor 1 in the macrophage response to group B streptococcus,' is now available. "Group B streptococcus (GBS), the most frequent single isolate in neonatal sepsis and meningitis, potently...

Research findings from Zhejiang University, Department of Stomatology update understanding of oral squamous cell carcinoma.(Report)
June 4, 2009... Researchers detail in 'Proteomic diagnosis models from serum for early detection of oral squamous cell carcinoma,' new data in oral squamous cell carcinoma. "The early diagnosis of oral squamous cell carcinoma (OSCC) is crucial to prevent...

Scientists at University of South Carolina, Department of Psychology discuss research in pain management.
June 4, 2009... A report, 'Use of handheld wireless technology for a home-based sickle cell pain management protocol,' is newly published data in Journal of Pediatric Psychology. In this recent report, researchers in the United States conducted a study "To...

Reports outline pharmacokinetics research from D.J. Touw and colleagues.
June 4, 2009... Fresh data on pharmacokinetics are presented in the report 'Therapeutic drug monitoring of aminoglycosides in neonates.' "The efficacy and toxicity of aminoglycosides show a strong direct positive relationship with blood drug concentrations,...

Research from University of Birmingham, Institute of Biomedical Research in the area of purpura prognosis published.
June 4, 2009... Fresh data on purpura are presented in the report 'Vasculitic IgA nephropathy: prognosis and outcome.' According to a study from the United Kingdom, "A vasculitic glomerulonephritis is seen in both IgA nephropathy and Henoch-Schonlein purpura....

Research from Military Hospital reveals new findings on sepsis animal studies.(Report)
June 4, 2009... New research, 'The effect of methylprednisolone on treatment in rats with induced sepsis,' is the subject of a report. According to recent research published in the journal Clinical and Experimental Medicine, "In this study, an appropriate...

Research from Rikshospitalet University, Institute of Immunology yields new data on sepsis immunology.
June 4, 2009... A report, 'Innate immune responses to danger signals in systemic inflammatory response syndrome and sepsis,' is newly published data in Scandinavian Journal of Immunology. According to recent research from Oslo, Norway, "The systemic immune...

New surgery study findings have been reported by researchers at National Defense Medical College, Department of Surgery.
June 4, 2009... A report, 'Role of translocation of pathogen-associated molecular patterns in sepsis,' is newly published data in Digestive Surgery. "Unlike animals, the incidence of bacterial translocation and its clinical significance remain to be determined...

Study findings from National University broaden understanding of acute myeloid leukemia.
June 4, 2009... According to a study from Singapore, Singapore, "L.-M. Poon, H.-Y. Chia, L.-K. Tan, T.-C. Liu, L.-P. Koh. Successful intensive chemotherapy followed by autologous hematopoietic cell transplantation in a patient with acute myeloid leukemia and...

Research findings from Army update understanding of adverse drug reactions.
June 4, 2009... According to recent research from the United States, "Helicopter transport of injured or ill patients in Operation Iraqi Freedom is a necessary but often high-risk endeavor. Our facility initiated a thorough process improvement and...

New allergies study results from F. Gally et al described.
June 4, 2009... "The multifunctional surface protein CD38 acts as a receptor with ecto-enzymatic activity, hydrolyzing NAD to generate several products known to exhibit Ca2+-mobilizing properties. Although CD38 is a convenient marker of immune cell...

Recent findings in alpha 1-antitrypsin deficiency described by researchers from Washington University.(Report)
June 4, 2009... "Oxidative stress is a key element in the pathogenesis of emphysema, but oxidation of nucleic acids has been largely overlooked. The aim of this study was to investigate oxidative damage to nucleic acids in severe emphysematous lungs,"...

New angiology study results reported from D. Demetriades et al.(Clinical report)
June 4, 2009... According to a study from the United States, "The traditional approach to stable blunt thoracic aortic injuries (TAI) is immediate repair, with delayed repair reserved for patients with major associated injuries. In recent years, there has been...

Research from L. Marquardt and co-researchers yields new findings on angiology.
June 4, 2009... According to a study from Oxford, the United Kingdom, "The higher risk of early recurrent stroke after posterior circulation transient ischaemic attack or minor stroke versus after carotid territory events could be due to a greater prevalence...

Data from M. Vallejo and colleagues advance knowledge in angiotensins.(Report)
June 4, 2009... "Angiotensin I-converting enzyme (ACE) insertion/deletion (I/D) polymorphism has been associated with the genetic susceptibility to several cardiovascular diseases; however, its association with cardiovascular risk factors (CRFs) in different...

New angiotensins study results reported from Nihon University.
June 4, 2009... "Combination therapy with multiple anti-hypertensives is required to achieve target blood pressure (BP) control and is recommended as the first-line therapy in hypertension. Although angiotensin receptor blockers (ARBs) may be combined with...

Study data from Technical University of Munich provide new insights into antithrombotics.(Report)
June 4, 2009... " Concern regarding the rate of delayed acute stent thrombosis associated with drug-eluting stent (DES) treatment has resulted in upward revision of the advised duration of dual antiplatelet therapy after DES implantation by both European and...

New apoptosis data have been reported by X.Y. Chen and co-authors.
June 4, 2009... According to recent research from Beijing, People's Republic of China, "Cardiotoxin III (CTX III), a 60-amino acid basic polypeptide isolated from Naja venom, showed potential therapeutic activity toward cancer cells. Here we report that CTX...

New apoptosis study findings reported from Kyoto Pharmaceutical University.
June 4, 2009... "The methanolic extract and its ethyl acetate-soluble fraction from the dried powder of cultured Cordyceps sinensis mycelium showed cytotoxic effects on promyelocytic leukemia HL-60 cells. Sitosterol (1), 5 alpha,8...

New findings from Kaohsiung Medical University in the area of apoptosis published.(Report)
June 4, 2009... According to recent research published in the journal Toxicology, "It has been reported that anti-inflammatory drugs (AIDs) inhibited bone repair in animal studies, and suppressed proliferation and induced cell death in rat osteoblast cultures....

Research on artificial saliva reported by scientists at Chulalongkorn University.
June 4, 2009... According to recent research published in the Journal of the American Dental Association, "The authors conducted an in vitro study to compare the hardness of normal enamel with enamel eroded by a cola soft drink and enamel remineralized by...

Research from Kobe University yields new data on atherosclerosis.(Report)
June 4, 2009... According to recent research published in the journal Cardiovascular Research, "Receptor for advanced glycation end products (RAGE) plays a pivotal role in the genesis of diabetic vascular diseases. To further explore the mechanisms underlying...

Study results from C. Karmonik and colleagues broaden understanding of atherosclerosis.
June 4, 2009... According to recent research from the United States, "The purpose of this paper is to evaluate the capability of feature space analysis (FSA) for quantifying the relative volumes of principal components (thrombus, calcification, fibrous, normal...

Reports from Polytechnic University describe recent advances in atrial fibrillation.
June 4, 2009... According to a study from Valencia, Spain, "The ventricular response during atrial fibrillation (AF) presents particular characteristics that may play a relevant role in the selection of the most appropriate treatment. Using different ECG...

Research results from I. Cruzgonzalez and co-authors update knowledge of atrial fibrillation.
June 4, 2009... "Patients with atrial fibrillation are at an increased risk of having a cardioembolic stroke. Most of the thrombi responsible for these ischemic events originate in the left atrial appendage (LAA)," researchers in the United States report (see...

Research findings from Y. Usui et al update understanding of autoimmune disease.
June 4, 2009... In this recently published article, scientists in Tokyo, Japan conducted a study "To examine the effects of bone marrow-derived regulatory dendritic cells (DCs) with potent immunoregulatory properties on the development of experimental...

Reports outline B-cell lymphoma study findings from Peking University.
June 4, 2009... "Intravascular large B-cell lymphoma (IVLBCL) is a rare subtype of diffuse large B-cell lymphoma (DLBCL). It commonly presents with a variety of symptoms due to occlusion of small vessels by tumor cells in different organ systems,"...

Reports summarize B-cell lymphoma study results from University of Thessaly.
June 4, 2009... "Inner centromere protein (INCENP) is a member of the Chromosomal Passenger Complex (CPC), which is a four member protein complex essential for proper completion of mitosis and cell division (cytokinesis). Inappropriate chromosomal segregation...

Research from A. Stathis and co-authors provides new data about B-cell lymphoma.
June 4, 2009... "Cytomegalovirus (CMV) is an opportunistic pathogen causing different diseases in immunocompromised patients and leading to death in a high percentage of cases. CMV infection is also relatively frequent among patients with hematological...

Scientists at Okayama University discuss research in B-cell lymphoma.
June 4, 2009... According to a study from Okayama, Japan, "We conducted a retrospective analysis to evaluate the impact on clinical outcomes of adding rituximab to cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) treatment for diffuse large...

Research reports on basal cell cancer from I. Elghissassi and colleagues provide new insights.
June 4, 2009... " Basal cell carcinoma (BCC) is the most common carcinoma in the community, but the incidence of metastatic events is exceedingly low. The few reported cases most often appear in regional nodes or the lungs, and patients usually exhibit...

Research on behavior detailed by scientists at University of Maryland.
June 4, 2009... In this recently published article, scientists in the United States conducted a study "To examine whether participants with the most behavioral goals to achieve were more likely to meet more goals than those given fewer goals. Eight hundred...

Study findings from Tufts University, Department of Agriculture broaden understanding of biochemistry.
June 4, 2009... "Genetic factors, specifically the VKORC1 and GGCX genes, have been shown to contribute to the interindividual variability in response to the vitamin K-antagonist, warfarin, which influences the dose required to achieve the desired...

New bioengineering findings from R. Falkner and co-authors described.
June 4, 2009... According to a study from London, the United Kingdom, "Is globalization promoting regulatory convergence in agricultural biotechnology policies in the South? This article examines the nature and limits of regulatory convergence in the field of...

New findings from University of Virginia in the area of bioengineering published.
June 4, 2009... According to a study from the United States, "AML1-ETO is the chimeric protein product of the t(8;21) in acute myeloid leukemia. The ETO portion of the fusion protein includes the eTAFH domain, which is homologous to several TATA binding...

Findings from Karolinska University advance knowledge in biologics.
June 4, 2009... "Tumour necrosis factor (TNF) antagonists have proved effective as treatment against rheumatoid arthritis ( RA), but the unresolved issue of whether the use of anti-TNF therapy increases the already elevated risk of lymphoma in RA remains a...

Reports from Laval University advance knowledge in bioluminescence.
June 4, 2009... According to recent research published in the journal Brain, "Activation of microglial cells in response to ischaemic injury, inflammatory and/or immune stimuli is associated with the marked induction of Toll-like receptor 2 (TLR2). At present,...

New biomedicine research from Purdue University discussed.(Report)
June 4, 2009... "Measurements of body sounds on the skin surface have been widely used in the medical field and continue to be a topic of current research, ranging from the diagnosis of respiratory and cardiovascular diseases to the monitoring of voice...

New biomedicine research from Shizuoka University outlined.
June 4, 2009... According to recent research published in the journal IEEE Transactions on Biomedical Engineering, "A new contactless technique for electrical impedance imaging, using an eddy current managed along with the tetrapolar circuit method, is...

Studies from L. Faes et al add new findings in the area of biomedicine.(Report)
June 4, 2009... According to recent research from Trento, Italy, "A method to perform time-varying (TV) nonlinear prediction of biomedical signals in the presence of nonstationarity is presented in this paper. The method is based on identification of TV...

Studies from University of Vienna have provided new information about biomedicine.
June 4, 2009... "We present an algorithm for discarding cardiopulmonary resuscitation (CPR) components from ventricular fibrillation ECG (VF ECG) signals and establish a method for comparing CPR attenuation on a common dataset. Removing motion artifacts in ECG...

Data on biopsy described by researchers at University of Leipzig.
June 4, 2009... According to recent research from Leipzig, Germany, "We report a clinical case of chronic myelogenous leukaemia (CML) with regional B-lymphoblastic transformation. Peripheral leukocytosis of 160 x 10(9)/L, splenomegaly and fatigue suggested...

Findings from University of Sydney provide new insights into blood pressure.
June 4, 2009... " To determine the value of monitoring blood pressure by quantifying the probability that observed changes in blood pressure reflect true changes. Analysis of blood pressure measurements of patients in the perindopril protection against...

New blood pressure research has been reported by scientists at Seoul National University.(Report)
June 4, 2009... "The objective of this study was to evaluate the merits of a blood pressure (BP) manometry feedback method for measurement of vestibular evoked myogenic potentials. Sixty ears of 30 normal volunteers were prospectively investigated,"...

Research data from University of Connecticut update understanding of blood pressure.
June 4, 2009... According to recent research from the United States, "Previous studies have evaluated the impact of oral magnesium on blood pressure; however, they used magnesium salts with low bioavailability, had methodological issues, and showed differing...

Research from Henry Ford Hospital yields new findings on blood pressure.(Clinical report)
June 4, 2009... "Energy drinks are frequently purported to improve cognitive function and concentration. However, the cardiovascular effects of these drinks have not been adequately studied," researchers in the United States report (see also Blood Pressure)....

Scientists at Teikyo University, Medical Department target blood pressure.(Report)
June 4, 2009... According to a study from Japan, "A higher degree of clinical efficacy with olmesartan compared with other angiotensin receptor blockers, has been reported by several sources. In this study of 31 examples of cases of essential hypertension,...

New bone marrow study findings have been published by scientists at Catholic University.(Report)
June 4, 2009... "Human mesenchymal stromal cells (MSCs) can be isolated from a variety of adult and perinatal tissues and exert multipotency and self renewal properties which make them suitable for cell-based therapy. Their potential plasticity extended to...

Reports from Tohoku University, Medical Department describe recent advances in bone marrow.
June 4, 2009... "The cysteinyl leukotrienes (LTs), LTC4, LTD4, and LTE4, are potent inflammatory mediators and are involved in allergic reactions, such as bronchoconstriction, eosinophilic inflammation, and allergic cell proliferation. The present study aimed...

Research data from University of Gothenburg, Sahlgrenska Academy update understanding of bone research.
June 4, 2009... According to a study from Gothenburg, Sweden, "Extensive bone grafting remains a delicate procedure, because of the slow and difficult integration of the grafted material into the physiological architecture. The recent use of platelet...

Research from M. Soltan et al has provided new information about bone research.
June 4, 2009... According to recent research from the United States, "Bone regeneration requires (in orchestrated interaction between various cells and other biological components. The synthesis of bone matrix with the release of cellular cytokines and growth...

Researchers from University of Sao Paulo detail findings in bone research.(Report)
June 4, 2009... According to recent research from Brazil, "The aim of this study was to evaluate the possibility of obtaining guided bone regeneration using a poly-tetrafluoroethylene (PTFE) nonporous barrier for 2 endosseous implants, partially inserted in...

New data from J. Hoffmann et al illuminate research in brain cancer.(Report)
June 4, 2009... "The aim of this study was to determine the efficacy of sagopilone (ZK-EPO), a novel epothilone, compared with other anticancer agents in orthotopic models of human primary and secondary brain tumors. Autoradiography and pharmacokinetic...

Studies from A.S. Costantini and co-researchers update current data on breast cancer.(Report)
June 4, 2009... According to recent research published in the journal Tumori, "Aims and background. Evidence of the association between leukemia and benzene exposure has been provided by several epidemiological studies." "An increased risk of breast...

Reports from Z.X. Li and colleagues advance knowledge in Burkitt lymphoma.
June 4, 2009... "Curcumin, a natural compound extracted from rhizomes of curcuma Curcuma species, has been shown to possess potent anti-inflammatory, anti-tumor and anti-oxidative properties. However, the mechanism of action of the compound remains poorly...