Blood Weekly articles from June 2003

Blood Weekly archives from June 2003

Oncogene-expressing stem cells downregulate tumor suppressor BRCA1.
June 5, 2003... 2003 JUN 5 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Hematopoietic stem cells expressing the oncogene BCR-ABL downregulate a key anti-cancer molecule, researchers in France report. "BCR-ABL fusion oncogene is...

Nonmyeloablative conditioning enables marrow-induced tolerance.
June 5, 2003... 2003 JUN 5 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - A nonmyeloablative conditioning regimen enables the induction of transgenic tolerance through bone marrow transplantation, according to researchers in Boston....

Intensified GVHD prophylaxis enables haploidentical stem cell transplants.
June 5, 2003... 2003 JUN 5 - (NewsRx.com & NewsRx.net) -- Intensified prophylaxis against graft-versus-host reactions enables haploidentical stem cell transplantation for acute lymphoblastic leukemia patients. Researchers in Japan described their...

Postnatal bone marrow stromal cells could stimulate therapeutic angiogenesis.
June 5, 2003... 2003 JUN 5 - (NewsRx.com & NewsRx.net) -- Postnatal bone marrow stromal cells could stimulate therapeutic angiogenesis. "Bone marrow stromal cells (MSCs) are pluripotent cells capable of differentiation into several tissue types. This...

Pumilio proteins expressed by murine hematopoietic cells.
June 5, 2003... 2003 JUN 5 - (NewsRx.com & NewsRx.net) -- Pumilio proteins are expressed by fetal and adult hematopoietic cells in mice. "Self-renewal is the common functional property of all types of stem cells and is thought to be regulated by unknown...

Adult bone marrow only reliable source of mesenchymal stem cells.
June 5, 2003... 2003 JUN 5 - (NewsRx.com & NewsRx.net) -- Adult bone marrow is the only consistent source of mesenchymal stem cells (MSCs). After birth, these cells "self-replicate, proliferate and differentiate into mesenchymal tissues, including bone,...

Gene dosage aids detection of 9p21 deletions in children.
June 5, 2003... 2003 JUN 5 - (NewsRx.com & NewsRx.net) -- Gene dosage aids the detection of chromosome abnormalities in pediatric leukemia patients. "Deletion of the 9p21 chromosomal region is frequently found in childhood acute lymphoblastic leukemia...

Antithymocyte globulin and cyclosporine can lead to Merkel cell carcinoma.
June 5, 2003... 2003 JUN 5 - (NewsRx.com & NewsRx.net) -- Antithymocyte globulin and cyclosporine therapy can lead to development of Merkel cell carcinoma. According to published research from Japan, "We report a patient who developed Merkel cell...

Theophylline induces progenitor cell apoptosis.
June 5, 2003... 2003 JUN 5 - (NewsRx.com & NewsRx.net) -- Theophylline lowers hematopoietic progenitor cell levels in asthma patients. This agent "possesses anti-inflammatory activities in asthma," researchers in Taiwan explained. In a recent study,...

AMEGA facilitates the selection of genetically modified cell populations.
June 5, 2003... 2003 JUN 5 - (NewsRx.com & NewsRx.net) -- AMEGA facilitates the selection of genetically modified cell populations. "While antibiotic selection has been routinely used for the selection of genetically modified cells, administration of...

Acquired von Willebrand syndrome occurs in some geriatric patients.
June 5, 2003... 2003 JUN 5 - (NewsRx.com & NewsRx.net) -- Acquired von Willebrand syndrome is an uncommon bleeding disorder that occurs in old age and may first appear with gastrointestinal bleeding or postoperatively, and can also be associated with...

FDA still lacks timetable for tissue bank oversight.
June 5, 2003... 2003 JUN 5 - (NewsRx.com & NewsRx.net) -- The U.S. Food and Drug Administration (FDA) says it has no timetable for long-delayed regulations governing hundreds of tissue banks despite at least one death from infected tissue and evidence of...

Phase Ib/II clinical trial for Hemospan begins.
June 5, 2003... 2003 JUN 5 - (NewsRx.com & NewsRx.net) -- Sangart, Inc., a biopharmaceutical company developing oxygen transport agents, announced the initiation of its phase Ib/II clinical trial for Hemospan (MP4) at the Karolinska Hospital in Stockholm,...

Lymphoproliferative disorder can have EBV infection in both B and T cells.
June 5, 2003... 2003 JUN 5 - (NewsRx.com & NewsRx.net) -- Lymphoproliferative disorder having EBV infection in both B and T cells can occur as a result of bone marrow transplant. "Post-transplantation lymphoproliferative disorder (PTLD) is usually an...

TNF-alpha production induced from human monocytes by beta-1,3-glucan oligomer.
June 5, 2003... 2003 JUN 5 - (NewsRx.com & NewsRx.net) -- A beta-1,3-glucan oligomer from laminarin induces tumor necrosis factor (TNF)-alpha production from human peripheral blood monocytes, Nagasaki University scientists demonstrated. "We prepared a...

Novel conditioning regimen enables mismatched stem cell transplants.
June 5, 2003... 2003 JUN 5 - (NewsRx.com & NewsRx.net) -- A novel conditioning regimen enables Fanconi anemia (FA) patients to safely receive stem cell grafts from partially mismatched donors. "Hematopoietic stem cell transplantation (HSCT) represents the...

Hemodialysis concentrate maker reports revenues, updates trials.
June 5, 2003... 2003 JUN 5 - (NewsRx.com & NewsRx.net) -- Rockwell Medical Technologies, Inc., (RMTI), a hemodialysis concentrate manufacturer, reported that its first quarter 2003 sales were $3,435,000, an increase of 40.5% over the first quarter of 2002. ...

Vaccine producer provides updates on corporate programs.
June 5, 2003... 2003 JUN 5 - (NewsRx.com & NewsRx.net) -- Acambis plc (ACAM) announced its results for the first quarter ended 31 March 2003. During the first quarter of 2003, there were a number of positive developments relating to our smallpox vaccine...

Method achieves RNA interference in differentiated embryonic stem cells.
June 5, 2003... 2003 JUN 5 - (NewsRx.com & NewsRx.net) -- According to University of Cambridge geneticists, "dsRNA of several hundred nucleotides in length is effective at interfering with gene expression in mouse oocytes, pre-implantation embryos, and...

Bleeding disorder tied to defect in cellular transport mechanism.
June 5, 2003... 2003 JUN 5 - (NewsRx.com & NewsRx.net) -- Defects in a cargo receptor that shuttles proteins from one place to another within the cell lie at the root of a rare bleeding disorder, according to a new study. An international research team...

Flt-3 ligand antagonizes thrombopoietin in myelosuppressed primates.
June 5, 2003... 2003 JUN 5 - (NewsRx.com & NewsRx.net) -- Flt-3 ligand antagonizes thrombopoietin (TPO) in rhesus macaques. According to recent research published in the British Journal of Haematology, "a placebo-controlled study evaluated the efficacy of...

Immunoglobulin failure and retreatment can occur in anemic pediatric patients.
June 5, 2003... 2003 JUN 5 - (NewsRx.com & NewsRx.net) -- About 10% of pediatric Kawasaki disease patients require retreatment by immunoglobulins due to failure. "Several cases of Kawasaki disease (KD) were unresponsive to the initial treatment with...

PTEN protein may be absent in B-CLL with a normal PTEN genotype.
June 5, 2003... 2003 JUN 5 - (NewsRx.com & NewsRx.net) -- PTEN protein may be absent in B-CLL with a normal PTEN genotype. According to a study from Switzerland, "One fifth of B-cell chronic lymphocytic leukemia (B-CLL) patients exhibit loss of...

Bone marrow stem cells may one day help treat damaged livers.
June 5, 2003... 2003 JUN 5 - (NewsRx.com & NewsRx.net) -- Research at Washington University School of Medicine in St. Louis suggests that stem cells from bone marrow or umbilical cord blood may be useful for treating people with liver damage due to cirrhosis,...

11778 Mutation does not change cellular response to cytotoxic drugs.
June 5, 2003... 2003 JUN 5 - (NewsRx.com & NewsRx.net) -- The 11778 mutation does not change cellular response to cytotoxic drugs. According to recent research from the United States, "Leber's hereditary optic neuropathy (LHON) is a bilateral subacute...

Chemotherapy has good results with epidural NHL if diagnosed promptly.
June 5, 2003... 2003 JUN 5 - (NewsRx.com & NewsRx.net) -- Chemotherapy has good results with epidural NHL if diagnosed promptly. "Spinal cord compression is a rare presentation of non-Hodgkin lymphoma," scientists writing in the journal Pediatric...

The origin of blood meals can help epidemiological tracking, using PCR.
June 5, 2003... 2003 JUN 5 - (NewsRx.com & NewsRx.net) -- The species origin of mosquito blood meals is beginning to be trackable. According to published research from the United States, "A PCR protocol was developed to identify host blood meals from...

Breakthrough needle-destruction device receives FDA approval.
June 5, 2003... 2003 JUN 5 - (NewsRx.com & NewsRx.net) -- The Center for Devices and Radiological Health (CDRH) of the U.S. Food and Drug Administration (FDA) has approved the sale and distribution of the Disintegrator PRO for clinical use. The...

Pluripotent neural progenitor cells are present in the adult human brain.
June 5, 2003... 2003 JUN 5 - (NewsRx.com & NewsRx.net) -- Multipotential neural progenitor cells are found in the subcortical white matter of the adult human brain. According to a study from the United States, "The subcortical white matter of the adult...

CBV conditioning for stem cell transplantation safe and effective.
June 5, 2003... 2003 JUN 5 - (NewsRx.com & NewsRx.net) -- A novel conditioning regimen is safe and effective for patients undergoing stem cell transplantation (SCT) to treat non-Hodgkin lymphoma (NHL). Allogeneic SCT "has been shown to be a curative...

Scientists uncover role of Fanconi anemia genes.
June 5, 2003... 2003 JUN 5 - (NewsRx.com & NewsRx.net) -- Scientists at the Johns Hopkins Kimmel Cancer Center have identified three genes, long linked to a rare inherited disease known as Fanconi anemia (FA), that now appear to play a role in many cases of...

China broadens usage of i-STAT system.
June 5, 2003... 2003 JUN 5 - (NewsRx.com & NewsRx.net) -- i-STAT Corporation (STAT), a manufacturer of point-of-care diagnostic systems for blood analysis, announced it is making stepped-up shipments of the i-STAT System to China. The shipments are part...

Disposition of a synthetic analogue of lipid A studied in rats.
June 5, 2003... 2003 JUN 5 - (NewsRx.com & NewsRx.net) -- Eisai & Co. Ltd. (Japan) is developing a treatment for sepsis resulting from Gram-negative bacterial infections. Company scientists recently characterized the disposition of the compound, E5564, a lipid...

Researchers call for changes.
June 5, 2003... 2003 JUN 5 - (NewsRx.com & NewsRx.net) -- The number of human stem cell lines available for research turns out to be far fewer than thought when President Bush placed limits on such studies more than a year ago. The finding that only 11...

Alliance with NIA follows completion of analyses of precursor cells.
June 5, 2003... 2003 JUN 5 - (NewsRx.com & NewsRx.net) -- Lynx Therapeutics, Inc., (LYNX) announced that it has entered into a service agreement with the National Institute on Aging (NIA) of the U.S. National Institutes of Health to study stem cell gene...

Bone marrow-derived hepatocytes arise from cell fusion.
June 5, 2003... 2003 JUN 5 - (NewsRx.com & NewsRx.net) -- Bone marrow-derived hepatocytes develop through cell fusion, rather than stem cell differentiation. "Evidence suggests that hematopoietic stem cells might have unexpected developmental plasticity,...

Genetically modified stem cells prevent juvenile diabetes in mice.
June 5, 2003... 2003 JUN 5 - (NewsRx.com & NewsRx.net) -- The Juvenile Diabetes Research Foundation International (JDRF) announced that researchers at the JDRF Center for Immunoregulation at the Walter and Eliza Hall Institute of Medical Research, Melbourne,...

Knowing pathways that regulate vascular stem cells opens up treatment choices.
June 5, 2003... 2003 JUN 5 - (NewsRx.com & NewsRx.net) -- Knowing pathways that regulate vascular stem cells opens up treatment choices. According to recent research published in the journal Trends in Molecular Medicine, "adult bone marrow is a rich...

Murine serpin 2A protein is intracellular and redox-sensitive.
June 5, 2003... 2003 JUN 5 - (NewsRx.com & NewsRx.net) -- The protein murine serpin 2A is intracellular and redox-sensitive. "Murine serpin 2A is expressed at high levels in hemopoietic progenitors and downregulated on differentiation," researchers in...

Novel epithelial-mesenchymal stromal cells identified in fetal liver.
June 5, 2003... 2003 JUN 5 - (NewsRx.com & NewsRx.net) -- A novel class of epithelial-mesenchymal stromal cells has been identified in the fetal liver. "Liver becomes the predominant site of hematopoiesis by 11.5. dpc (days after coitus) in the mouse and...

Patented stem cell expansion technology acquired.
June 5, 2003... 2003 JUN 5 - (NewsRx.com & NewsRx.net) -- A.I. Software, Inc., (ASOW) announced that it has reached an agreement with the Weitzman Institute of Science and Technion - Israel Institute of Technology to acquire the exclusive rights of stem cell...

Platelet-derived growth factor upregulates megakaryocytic transcription factors.
June 5, 2003... 2003 JUN 5 - (NewsRx.com & NewsRx.net) -- Platelet-derived growth factor (PDGF) increases transcription factor expression by platelet progenitor cells. PDGF "is a platelet alpha-granule protein," according to researchers in China who...

Selective amplifier genes containing c-Mpl augment hematopoietic cell expansion.
June 5, 2003... 2003 JUN 5 - (NewsRx.com & NewsRx.net) -- Selective amplifier genes containing c-Mpl augment hematopoietic cell expansion. "We previously developed 'selective amplifier genes (SAGs)' which confer a growth advantage to transduced cells. The...

The tetrapeptide AcSDKP induces angiogenesis in vitro and in vivo.
June 5, 2003... 2003 JUN 5 - (NewsRx.com & NewsRx.net) -- The tetrapeptide AcSDKP induces angiogenesis in vitro and in vivo. According to published research from France, "the tetrapeptide acetyl-Ser-Asp-Lys-Pro (AcSDKP), purified from bone marrow and...

Allografts effective against chronic granulomatous disease.
June 5, 2003... 2003 JUN 5 - (NewsRx.com & NewsRx.net) -- Allogeneic stem cell transplantation is effective against chronic granulomatous disease (CGD). According to published research from Italy, CGD "is a rare primary immunodeficiency caused by an...

Cidofovir effective but toxic for adenovirus-infected patients.
June 5, 2003... 2003 JUN 5 - (NewsRx.com & NewsRx.net) -- Cidofovir is effective but toxic for stem cell graft recipients with posttransplant adenovirus infections. "Adenovirus is an important cause of morbidity and mortality after allogeneic...

Cord blood grafts linked to heightened cytomegalovirus risk.
June 5, 2003... 2003 JUN 5 - (NewsRx.com & NewsRx.net) -- Umbilical cord blood-derived stem cell grafts carry a higher risk of cytomegalovirus (CMV) infection than adult grafts. In a recent study from Japan, CMV infection "in 28 adult patients after cord...

Extracorporeal photopheresis moderately effective against GVHD.
June 5, 2003... 2003 JUN 5 - (NewsRx.com & NewsRx.net) -- Extracorporeal photopheresis treatment is moderately effective in controlling graft-versus-host reactions after stem cell transplantation. Scientists in the United States "conducted a retrospective...

Feto-maternal microchimerism prevents T-cell reactions.
June 5, 2003... 2003 JUN 5 - (NewsRx.com & NewsRx.net) -- Cancer patients can safely receive T cell-replete stem cell grafts from haploidentical mothers. "Feto-maternal microchimerism suggests that immunologic tolerance exists between mother and fetus,"...

GVHD effects similar in normal and reduced-intensity transplants.
June 5, 2003... 2003 JUN 5 - (NewsRx.com & NewsRx.net) -- Graft-versus-host reactions have similar effects on the results of conventional and reduced-intensity stem cell transplants. "To clarify the impact of graft-versus-host disease (GVHD) on the...

Metronidazole alters busulfan pharmacokinetics.
June 5, 2003... 2003 JUN 5 - (NewsRx.com & NewsRx.net) -- Metronidazole alters the pharmacokinetics of busulfan (Bu) in stem cell transplant recipients. Bu "is an important component of some myeloablative regimens prior to stem cell transplantation...

Single leukapheresis should be used for pediatric solid tumor patients.
June 5, 2003... 2003 JUN 5 - (NewsRx.com & NewsRx.net) -- A single leukapheresis session should be used to collect stem cells from children with high-risk solid tumors. In a recent study from South Korea, "eighteen of 26 double high-dose chemotherapies...

Treatment effective for t(8;13)-related myeloproliferative disorder.
June 5, 2003... 2003 JUN 5 - (NewsRx.com & NewsRx.net) -- Stem cell transplantation can resolve a myeloproliferative condition linked to the t(8;13) translocation. According to recent research from France, "a rare atypical myeloproliferative disorder...

Johns Hopkins receives $24 million from Donald W. Reynolds Foundation.
June 5, 2003... 2003 JUN 5 - (NewsRx.com & NewsRx.net) -- The Johns Hopkins University School of Medicine has been awarded a 4-year, $24 million gift from the Las Vegas-based Donald W. Reynolds Foundation to establish a multidisciplinary center focused...

Study finds deferiprone provides significantly greater cardiac protection.
June 5, 2003... 2003 JUN 5 - (NewsRx.com & NewsRx.net) -- Iron-induced heart disease is the major cause of death in patients with the genetic blood disorder, thalassemia. A new published study reveals that long-term therapy with deferiprone (Ferriprox)...

Short-term, high-dose cyclosporin may be useful in pediatric refractory disease.
June 5, 2003... 2003 JUN 5 - (NewsRx.com & NewsRx.net) -- Pediatric patients with refractory chronic idiopathic thrombocytopenia purpura may be treatable with cyclosporin A. According to a study from Italy, "We report on 14 children (7 boys, 7 girls) with...

Methods to reduce bacterial infections from blood transfusions considered.
June 5, 2003... 2003 JUN 5 - (NewsRx.com & NewsRx.net) -- A number of methods to reduce the incidence of bacterial infections caused by blood transfusions are under consideration. "In the United States, septic reactions from bacterial contamination of...

Quality of life reports linked to hemoglobin levels in MDS patients.
June 5, 2003... 2003 JUN 5 - (NewsRx.com & NewsRx.net) -- Quality of life reports are correlated with hemoglobin levels in patients with transfusion-dependent myelodysplastic syndromes (MDS). These conditions "are clonal disorders characterized by...

Bacterial molecules activate cord blood-derived mast cells.
June 5, 2003... 2003 JUN 5 - (NewsRx.com & NewsRx.net) -- Bacterial molecules activate mast cells derived from human umbilical cord blood. Researchers at the University of Paris "analyzed whether human normal cord blood-derived mast cells (CBMC) could...

Fibrinogen promotes megakaryocytopoiesis, but not thrombopoiesis.
June 5, 2003... 2003 JUN 5 - (NewsRx.com & NewsRx.net) -- Fibrinogen promotes megakaryocytopoiesis, but not thrombopoiesis in umbilical cord blood. "Megakaryocyte differentiation is composed of three distinct stages: formation of erythromegakaryocytic...

Novel purification method improves Langerhans cell yield.
June 5, 2003... 2003 JUN 5 - (NewsRx.com & NewsRx.net) -- A novel purification method improves the potential yield of epidermal Langerhans cells (LCs) from umbilical cord blood. LCs "are a subset of immature dendritic cells (DCs) and play a key role in...

Blood supply company reports first quarter financial results.
June 5, 2003... 2003 JUN 5 - (NewsRx.com & NewsRx.net) -- V.I. Technologies (Vitex), Inc., (VITX), a biotechnology company dedicated to developing products that improve the safety of the transfusion blood supply, announced its financial results for the first...

Endothelial progenitor-like cells are angiogenesis-selective gene vectors.
June 5, 2003... 2003 JUN 5 - (NewsRx.com & NewsRx.net) -- Endothelial progenitor-like cells are angiogenesis-selective gene vectors. According to recent research from Canada, "human and mouse proliferation-competent, bone marrow or peripheral circulation...

CDC inks licensing agreement for test for WNV.
June 5, 2003... 2003 JUN 5 - (NewsRx.com & NewsRx.net) -- Spectral Diagnostics, Inc., (SDI) announced the signing of a licensing agreement with the U.S. Centers for Disease Control (CDC) to develop a rapid point-of-care test for West Nile Virus (WNV)...

Immune transfer through stem cell transplantation effective.
June 12, 2003... 2003 JUN 12 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Researchers in Germany have identified a novel method of inducing immunity to hepatitis B virus (HBV) infection. "Previous data indicate that a transfer of...

Cryopreservation does not lower dendritic cell immunogenicity.
June 12, 2003... 2003 JUN 12 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Cryopreservation of human dendritic cells should not reduce their efficacy in cancer vaccines, researchers in Germany have found. "In the past decade...

Recombinant tissue plasminogen activator effective against HVOD.
June 12, 2003... 2003 JUN 12 - (NewsRx.com & NewsRx.net) -- Recombinant tissue plasminogen activator (rtPA) can be used to manage hepatic veno-occlusive disease (HVOD) in pediatric bone marrow recipients. HVOD "following bone marrow transplantation is...

Mitochondrial DNA mutations play little role in development.
June 12, 2003... 2003 JUN 12 - (NewsRx.com & NewsRx.net) -- Mitochondrial DNA mutations play little role in the development of myelodysplastic syndromes. Scientists in the United States "undertook to systematically analyze the entire mitochondrial genome...

Reduced-intensity rituximab-BEAM-CAMPATH stem cell transplants effective.
June 12, 2003... 2003 JUN 12 - (NewsRx.com & NewsRx.net) -- Stem cell transplants with reduced-intensity rituximab-BEAM-CAMPATH conditioning are safe and effective for lymphoma patients. "The indolent non-Hodgkin's lymphomas are theoretically curable...

PBX1 suppression produces "ultra-competitive" HOXB4-transduced cells.
June 12, 2003... 2003 JUN 12 - (NewsRx.com & NewsRx.net) -- Suppressing PBX1 expression by HOXB4-transduced stem cells dramatically augments competition. In a previous study, scientists in Canada "showed that HOXB4 is a potent stimulator of hematopoietic...

Flow cytometric assay detects apoptosis proteins in residual tumor cells.
June 12, 2003... 2003 JUN 12 - (NewsRx.com & NewsRx.net) -- A flow cytometric assay can measure apoptosis protein expression by residual leukemia cells. "Minimal residual disease (MRD) cells are thought to be responsible for the persistence and relapse of...

Company provides guidance on timing of MBI 226 phase III results.
June 12, 2003... 2003 JUN 12 - (NewsRx.com & NewsRx.net) -- Micrologix Biotech, Inc., (MGIXF) issued its quarterly CEO message in which Dr. Jim DeMesa, president and CEO, provided comments on various company activities, including an update on the timing of...

Anemia practice guidelines provide direction on dosing of erythropoietic agents.
June 12, 2003... 2003 JUN 12 - (NewsRx.com & NewsRx.net) -- The National Comprehensive Cancer Network (NCCN) has issued new "Cancer and Treatment-Related Anemia Practice Guidelines" for physicians that provide new insights on the management of cancer and...

The risk of Hodgkin disease may be associated with exposure to infections.
June 12, 2003... 2003 JUN 12 - (NewsRx.com & NewsRx.net) -- The risk of Hodgkin disease may be associated with exposure to infections. According to a study from England, "In a retrospective cohort study of 404,106 live births in the northern region of...

ST1571 effective for relapsed patients with advanced disease.
June 12, 2003... 2003 JUN 12 - (NewsRx.com & NewsRx.net) -- The novel anti-leukemia agent ST1571 can be effective for patients with advanced disease who relapse after stem cell transplantation. Scientists in Germany assessed "the response to the ABL kinase...

High-dose BCNU chemotherapy with autologous stem cell rescue feasible.
June 12, 2003... 2003 JUN 12 - (NewsRx.com & NewsRx.net) -- Intensive BCNU chemotherapy with autologous stem cell rescue is feasible for patients with advanced gliomas. "Conventional treatment of high-grade glioma includes maximal surgical resection...

Neonatal blood plasma less susceptible than adult plasma to oxidation.
June 12, 2003... 2003 JUN 12 - (NewsRx.com & NewsRx.net) -- Neonatal blood plasma is less susceptible to oxidative damage than adult plasma. "Newborn infants are susceptible to a range of problems attributed to excessive production of free radicals,"...

BIC expression marks Reed-Sternberg cells.
June 12, 2003... 2003 JUN 12 - (NewsRx.com & NewsRx.net) -- A protein expressed almost exclusively by Hodgkin lymphoma (HL) cells. "In a search for genes specifically expressed in Reed-Sternberg (IRS) cells of Hodgkin lymphoma," researchers in the...

Ligands binding human prion proteins targeted.
June 12, 2003... 2003 JUN 12 - (NewsRx.com & NewsRx.net) -- Scientists at Pathogen Removal and Diagnostic Technologies Inc. (PRDT), a joint venture company set up by the American Red Cross and ProMetic Life Sciences Inc., have selected seven ligands that bind...

Blood screening test detects other members of the West Nile virus family.
June 12, 2003... 2003 JUN 12 - (NewsRx.com & NewsRx.net) -- Roche Diagnostics announced that U.S. and Canadian clinical trials for its new assay for detecting West Nile virus in donated blood are scheduled to being by July 1. While the trials are designed...

Cryptosporidium may be cause of severe diarrhea during chemotherapy.
June 12, 2003... 2003 JUN 12 - (NewsRx.com & NewsRx.net) -- Cryptosporidium infection may be responsible for severe diarrhea in pediatric leukemia patients. According to a study from the United Arab Emirates, "four children on chemotherapy for acute...

Cotreatment with SAHA enhances the cytotoxic effects of imatinib.
June 12, 2003... 2003 JUN 12 - (NewsRx.com & NewsRx.net) -- Cotreatment with SAHA enhances the cytotoxic effects of imatinib. According to recent research from the United States, "Here we demonstrate that treatment with SAHA (suberoylanilide hydroxamic...

BCL6 deregulation is involved in DLBCL pathogenesis.
June 12, 2003... 2003 JUN 12 - (NewsRx.com & NewsRx.net) -- BCL6 deregulation is involved in DLBCL pathogenesis. According to a study from the United States, "The BCL6 proto-oncogene encodes a transcriptional repressor whose expression is deregulated by...

New Revimid data shows potential as MDS treatment.
June 12, 2003... 2003 JUN 12 - (NewsRx.com & NewsRx.net) -- Data presented at the Seventh International Symposium on Myelodysplastic Syndromes in Paris demonstrated Revimid (CC-5013) as a potential new agent for treating myelodysplastic syndromes (MDS). ...