Blood Weekly articles from July 2009

Blood Weekly archives from July 2009

Advance in understanding cellulose synthesis.
July 2, 2009... Cellulose is a fibrous molecule that makes up plant cell walls, gives plants shape and form and is a target of renewable, plant-based biofuels research. But how it forms, and thus how it can be modified to design energy-rich crops, is not well...

New mechanism fundamental to the spread of invasive yeast infections identified.
July 2, 2009... A group of researchers led by Carnegie Mellon University Biological Sciences Professor Aaron Mitchell has identified a novel regulatory gene network that plays an important role in the spread of common, and sometimes deadly, yeast infections....

Peripheral nerve repair with fat precursor cells led to wider nerves and less muscle atrophy.
July 2, 2009... To determine if guided fat (adipose) precursor cells (APCs) could improve nerve regeneration and functional recovery, researchers at the University of Pittsburgh (USA) used biodegradable nerve guides to transplant APCs into the injured...

Another McGill/JGH breakthrough opens door to early Alzheimer's diagnosis.
July 2, 2009... This press release is available in French. A new diagnostic technique which may greatly simplify the detection of Alzheimer's disease has been discovered by researchers at McGill University and the affiliated Lady Davis Institute for Medical...

An alternative treatment for hypervascular hepatocellular carcinoma.
July 2, 2009... HCC is the fifth most common cancer in the world and the third most frequent cause of cancer-related death. Only about 20% of HCC patients are eligible for surgical resection. Therefore, RFA has been used increasingly as a safe technique for...

New hematologic disease research from A. Dodero et al outlined.
July 2, 2009... "Haploidentical hematopoietic stem cell transplantation provides an option for patients with advanced hematologic malignancies lacking a compatible donor. In this prospective phase 1/2 trial, we evaluated the role of reduced-intensity...

New findings reported from Vanderbilt University describe advances in hydatidiform mole.
July 2, 2009... "Partial molar pregnancy with coexisting fetus is a rare complication of pregnancy and carries significant risks to both the mother and the fetus," scientists in the United States report (see also Hydatidiform Mole). "Maternal risks...

New findings from A.M. Asemissen and co-authors in the area of immunotherapy published.(Report)
July 2, 2009... According to recent research from Berlin, Germany, "PAX2 is a transcription factor and member of the highly conserved family of paired box genes. PAX2 is aberrantly expressed in a variety of solid and hematologic malignancies." "PAX2...

Studies conducted at Children's Hospital on iron overload recently published.
July 2, 2009... According to recent research from the United States, "R2* magnetic resonance imaging (R2*-MRI) can quantify hepatic iron content (HIC) by noninvasive means but is not fully investigated. Patients with iron overload completed 1.5T R2*-MRI...

Reports by W.X. Li and co-researchers describe recent advances in kidneys.
July 2, 2009... " The optimal timing to start continuous renal replacement therapy (CRRT) for acute kidney injury (AKI) patients has not been accurately established. The recently proposed risk, injury, failure, loss, end-stage kidney disease (RIFLE) criteria...

Data on life sciences detailed by J. Koenigsmann and co-authors.
July 2, 2009... "Loss of neurofibromin or interferon consensus sequence binding protein (Icsbp) leads to a myeloproliferative disorder. Transcription of NF1 is directly controlled by ICSBP," researchers in Berlin, Germany report (see also Life Sciences). ...

Investigators at University of Amsterdam zero in on life sciences.
July 2, 2009... According to recent research from Netherlands, "Leukocyte adhesion deficiency-1/variant (LAD1v) syndrome presents early in life and manifests by infections without pus formation in the presence of a leukocytosis combined with a Glanzmann-type...

New life sciences research from Fukuoka University discussed.
July 2, 2009... According to recent research from Fukuoka, Japan, "The blood-brain barrier (BBB) is highly restrictive of the transport of substances between blood and the central nervous system. Brain pericytes are one of the important cellular constituents...

New life sciences study findings have been reported by scientists at Cincinnati Children's Hospital.
July 2, 2009... "The zinc finger protein growth factor independent-1 (Gfi1) is a transcriptional repressor that is critically required for normal granulocytic differentiation. GFI1 loss-of-function mutations are found in some patients with severe congenital...

New life sciences study findings recently were reported by S. Wutzler and co-researchers.
July 2, 2009... According to a study from Frankfurt, Germany, "Monocytes represent a key immunocompetent cell type, whose functional capacity is profoundly influenced by systemic trauma. Because data on monocyte function in a heterogeneous trauma population,...

Reports summarize life sciences research from R.C. Piazza and co-authors.
July 2, 2009... According to recent research from the United States, "As burn wound sepsis continues to be one of the most common causes of death in burn patients, it is important to note the trend of increased involvement of fungal pathogens." "Very...

Researchers at University of Alabama have published new data on life sciences.(Report)
July 2, 2009... "Approximately 50% of fatal and 15% of nonfatal burn-injured patients have detectable blood alcohol content (BAC) at the time of admission, and it is hypothesized that alcohol exacerbates burn-related immunosuppression. The purpose of this...

Researchers from University of Nottingham report recent findings in life sciences.
July 2, 2009... According to recent research from Loughborough, the United Kingdom, "A cross-sectional study was conducted to evaluate the seroprevalence of and risk factors for Toxoplasma gondii antibodies in 260 blood donors seen at blood banks in Mansoura...

Studies from E. Bosque et al in the area of life sciences described.
July 2, 2009... "This article is a complex case study of an infant, born at 33 2/7 weeks' gestation, with restrictive dermopathy, who died at 5 weeks of age. The review of perinatal and postnatal courses, as well as the rare disorder of restrictive dermopathy,...

Data on malaria published by researchers at University of Virginia.
July 2, 2009... According to recent research from the United States, "We enrolled 382 patients at two hospitals in Uganda ill a prospective observational Study of severe sepsis. Because artemisinins improve Survival in murine sepsis models, we performed a post...

Researchers from Yonsei University, Medical Department discuss findings in myelodysplastic syndrome.
July 2, 2009... According to recent research from Seoul, South Korea, "We describe a novel case of simultaneous karyotypic abnormalities of isochromosome 17q and trisomy 14 in a patient with myelodysplastic syndrome (MDS) in leukemic transformation. A...

Studies in the area of myelodysplastic syndrome reported from T.J. Gaymes and co-researchers.(Report)
July 2, 2009... According to recent research from London, the United Kingdom, " Aberrant or impaired repair of double-strand DNA breaks is a common feature of de novo acute myeloid leukemia and myelodysplastic syndromes. Since poly (ADP-ribose) polymerase...

Study findings from University of Dusseldorf provide new insights into myelodysplastic syndrome.
July 2, 2009... "We studied the impact of comorbidities on survival and evaluated the prognostic utility of comorbidity scores in MDS patients, who received best supportive care and were assessable according to the Charlson Comorbidity Index (CCI) and the...

Individuals Who Apply Pesticides Are Found to Have Double the Risk of Blood Disorder.
July 2, 2009... A study involving 678 individuals who apply pesticides, culled from a U.S. Agricultural Health Study of over 50,000 farmers, recently found that exposure to certain pesticides doubles one's risk of developing an abnormal blood condition called...

Recent findings in neutropenia described by Y.T. Li and colleagues.(Report)
July 2, 2009... According to recent research from the United States, "Neutropenia and related infections are the most important dose-limiting toxicities in anticancer chemotherapy and radiotherapy. In this study, we explored a new strategy for augmenting host...

Scientists at Mayo Clinic publish research in neutropenia.
July 2, 2009... "Cyclic neutropenia (CN) is a rare genetic disorder where patients experience regular cycling of numbers of neutrophils and various other haematopoietic lineages. The nadir in neutrophil count is the main source of problems due to risk of...

New research on peritonitis from A. Sandberg and co-authors summarized.
July 2, 2009... "Antibiotic treatment of Staphylococcus aureus infections is often problematic due to the slow response to therapy and the high frequency of infection recurrence. The intracellular persistence of staphylococci has been recognized and could...

Researchers from Catholic University, Medical Department provide details of new studies and findings in the area of pharmacokinetics.(Report)
July 2, 2009... According to a study from Seoul, South Korea, "Empirical use of intravenous (IV) itraconazole (ITZ) for febrile neutropenic patients has recently been introduced in Korea. This study was designed to investigate the population pharmacokinetics...

Research on pheochromocytoma detailed by scientists at Dongguk University.
July 2, 2009... According to recent research from South Korea, "A 48-year-old man presented for evaluation of general weakness. Because he had a history of excessive alcohol use, an abdominal computed tomography scan was obtained, which revealed a left adrenal...

Findings in pneumonia reported from Panjab University.
July 2, 2009... "Despite extensive research, the mortality associated with sepsis in hospitals remains very high. We have evaluated the protective immunomodulatory effect of thalidomide alone or with Augmentin in Klebsiella pneumoniae B5055-induced sepsis in...

Study data from S.R. Eachempati and co-authors update knowledge of pneumonia.
July 2, 2009... According to recent research from the United States, "Ventilator-associated pneumonia (VAP) is a leading cause of mortality in critically ill patients. Although previous studies have shown that de-escalation therapy (DT) of antibiotics may...

Study results from G.L. Daikos et al provide new insights into pneumonia.(Clinical report)
July 2, 2009... "VIM-1-producing Klebsiella pneumoniae (VPKP) is an emerging pathogen. A prospective observational study was conducted to evaluate the importance of VIM production on outcome of patients with K. pneumoniae bloodstream infections (BSIs),"...

Studies in the area of Pseudomonas aeruginosa reported from INSERM.
July 2, 2009... "The search for new molecules to fight Pseudomonas aeruginosa is of paramount importance. Carbon monoxide (CO) is known to act as an effective inhibitor of the respiratory chain in P. aeruginosa, but the practical use of this gas as an...

Researchers from Catholic University discuss findings in purpura.
July 2, 2009... "Developing mechanistic models to predict an organism's body temperature facilitates the study of physiological stresses caused by extreme climatic conditions the species might have faced in the past or making predictions about changes to come...

Studies from N.H. Cox and colleagues yield new information about purpura.
July 2, 2009... "Surgical bleeding and occasionally purpura due to calcium-channel blockers have been described. To present cases in whom purpura or internal bleeding due to calcium-channel blockers was a presenting feature, including one subject with...

454 Life Sciences Celebrates a Revolution in Genomics - Announces the 454th Peer-Reviewed Publication Using the Genome Sequencer System.
July 2, 2009... In September 2005, a paper published in the journal Nature introducing a novel, highly parallel sequencing system capable of producing 100-fold greater throughput than the state-of-the-art capillary electrophoresis instrument. The paper...

Data from Taipei Medical University advance knowledge in sepsis.(Report)
July 2, 2009... "The purpose of this study was to investigate whether physicians with larger sepsis caseloads provide better outcomes, defined as lower in-hospital mortality rates, for patients with sepsis. Retrospective cross-sectional study. This study used...

Investigators at University of Schleswig-Holstein have published new data on sepsis.
July 2, 2009... According to recent research published in the journal Diagnostic Pathology, "Pattern recognition receptors are a key component of the first line host defense against infection, recognizing specific microbial products. We hypothesize that...

New sepsis research reported from University of Halle-Wittenberg.
July 2, 2009... According to recent research published in the Canadian Journal of Physiology and Pharmacology, "In sepsis, systemic inflammatory response syndrome (SIRS), and multiorgan dysfunction syndrome (MODS), a severe prognostically relevant cardiac...

Research data from Shandong University update understanding of sepsis.
July 2, 2009... According to a study from Jinan, People's Republic of China, "Physical and immunologic barriers of the small intestine play an important role in development and treatment of sepsis, so a rat model of sepsis was used to investigate the effect of...

Spectral announces publication demonstrating Toraymyxin(TM) significantly reduces mortality from sepsis in prospective controlled trial.
July 2, 2009... Spectral Diagnostics Inc. (TSX:SDI), a company developing products for the treatment of sepsis, announced that findings demonstrating the Toraymyxin(TM) cartridge, a blood purification device that absorbs endotoxin from the bloodstream, when...

Study data from University of Lille, Medical Department update knowledge of sepsis.
July 2, 2009... "Use of metal carbonyl-based compounds capable of releasing carbon monoxide (CO) in biological systems have emerged as a potential adjunctive therapy for sepsis via their antioxidant, anti-inflammatory, and antiapoptotic effects. The role of CO...

New sickle cell anemia study findings reported from A. Koren and co-authors.
July 2, 2009... "Sickle cell anemia is a hemolytic anemia caused by a single mutation in position 6 of the P globin molecule. About 80 patients with SCA in northern Israel are currently receiving treatment," investigators in Afula, Israel report (see also...

Studies from University of South Carolina provide new data on spherocytosis.
July 2, 2009... "Hereditary spherocytosis is a common form of hemolytic anemia sometimes requiring splenectomy in recalcitrant cases. The complications of splenectomy include an increased risk of thrombosis, usually presenting with deep vein thrombosis or...

St. Joseph Hospital Named a Center of Medical Excellence for Kidney Transplants.
July 2, 2009... St. Joseph Hospital has recently met criteria to participate in Anthem Center of Excellence for Medical Transplantation. The hospital has been named a Blue Distinction Center for kidney transplantation by the Blue Cross and Blue Shield...

Data on thrombocytopenia detailed by researchers at University of Perugia.
July 2, 2009... " Defects of integrin alpha(IIb)beta(3) are typical of Glanzmann's thrombasthenia, an inherited autosomal recessive bleeding disorder characterized by the failure of platelets to aggregate in response to all physiological agonists, but with no...

New findings in thrombocytopenic purpura described from University of Illinois.
July 2, 2009... "To review the pharmacology, pharmacokinetics, efficacy, and safety of romiplostim, the first drug approved for use in patients with immune thrombocytopenic purpura (ITP). Articles were identified through searches of MEDLINE (1966-January 2009)...

Reports outline thyroid cancer research from University Hospital.
July 2, 2009... "Two cases of an extremely rare paraganglioma-like variant of medullary thyroid carcinoma (MTC) are reported. The patients were a 65-year-old male (case 1) and a 14-year-old female (case 2)," scientists writing in the journal Cytopathology...

Research on transplantation detailed by S.W. Kim and co-authors.
July 2, 2009... "To evaluate the toxicity and efficacy of an i.v. preparation of BU (12.8 mg/kg), combined with CY (120 mg/kg), a prospective study was performed on 30 Japanese patients (median age, 30 years) with hematologic malignancies undergoing...

Research on acute myeloid leukemia therapy discussed by scientists at University of Freiburg.
July 2, 2009... Fresh data on acute myeloid leukemia are presented in the report 'The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells.' According to a...

Study data from University of Szeged update knowledge of acute pancreatitis genetics.
July 2, 2009... Data detailed in 'Plasma concentrations of high-mobility group box protein 1, soluble receptor for advanced glycation end-products and circulating DNA in patients with acute pancreatitis' have been presented. "High-mobility group box protein 1...

Researchers' work from Sanjay Gandhi Postgraduate Institute of Medical Sciences, Department of Transfusion Medicine focuses on autoimmune hemolytic anemia.(Report)
July 2, 2009... Research findings, 'Clinical and serological characterization of autoimmune hemolytic anemia in a tertiary care hospital in North India,' are discussed in a new report. According to recent research from Lucknow, India, "Clinical and serological...

Research from Ogaki Municipal Hospital, Department of Dermatology in the area of dermatology described.
July 2, 2009... Researchers detail in 'Autoerythrocyte sensitization syndrome with vertigo and hemilateral auditory impairment,' new data in dermatology. "Autoerythrocyte sensitization syndrome (AES) is characterized by recurrent, painful purpura or...

Data from University of Tubingen, Department of Physiology advance knowledge in hemolysis cell biology.
July 2, 2009... New investigation results, 'Hemin-induced suicidal erythrocyte death,' are detailed in a study published in Annals of Hematology. "Several diseases, such as malaria, sickle cell disease, and ischemia/reperfusion may cause excessive formation of...

Researchers from University of Virginia publish findings in life sciences.
July 2, 2009... Investigators publish new data in the report 'Linezolid-induced purpuric medication reaction.' According to a study from the United States, "A 64-year-old Caucasian male was seen in consultation for a petechial eruption that began 9 days after...

Research findings from University of Stellenbosch, Department of Radiology update understanding of lymphadenopathy in children.
July 2, 2009... Researchers detail in 'Comparing three-dimensional volume-rendered CT images with fibreoptic tracheobronchoscopy in the evaluation of airway compression caused by tuberculous lymphadenopathy in children,' new data in lymphadenopathy....

New magnetic resonance in children study findings recently were published by G.R. Kirk and co-researchers.
July 2, 2009... Data detailed in 'Regionally specific cortical thinning in children with sickle cell disease' have been presented. According to recent research published in the journal Cerebral Cortex, "Sickle cell disease (SCD) is a chronic disease with a...

Researchers from Kyoto University publish findings in myelodysplastic syndrome.
July 2, 2009... A new study, 'Simultaneous occurrence of inflammatory bowel disease and myelodysplastic syndrome due to chromosomal abnormalities in bone marrow cells,' is now available. According to a study from Kyoto, Japan, "Although chromosomal...

New neutropenia study findings recently were published by researchers at College of Medicine, Division of Hematology.(Clinical report)
July 2, 2009... Research findings, 'Progenitor cell self-renewal and cyclic neutropenia,' are discussed in a new report. "Cyclic neutropenia (CN) is a rare genetic disorder where patients experience regular cycling of numbers of neutrophils and various other...

Research conducted at Post Graduate Institute of Medical Education and Research has updated our knowledge about purpura in children.(Report)
July 2, 2009... Investigators publish new data in the report 'Serum and urine nitric oxide levels in children with Henoch-Schonlein purpura during activity and remission: a study from North India.' "The objective of this study is to compare serum and urine...

Study results from Kitasato University provide new insights into purpura.
July 2, 2009... Data detailed in 'Henoch-Schönlein pupura complicated by perforation of the gallbladder' have been presented. "Henoch-Schönlein purpura is a systemic vasculitis of small vessels characterized by purpura, arthralgias,...

Study results from N.H. Cox and colleagues broaden understanding of purpura.
July 2, 2009... A report, 'Purpura and bleeding due to calcium-channel blockers: an underestimated problem? Case reports and a pilot study,' is newly published data in Clinical & Experimental Dermatology. "Surgical bleeding and occasionally purpura due to...

New sepsis in children study findings recently were published by researchers at Kings College, Department of Dermatology.
July 2, 2009... A report, 'Ecthyma gangrenosum: an important feature of pseudomonal sepsis in a previously well child,' is newly published data in Clinical & Experimental Dermatology. "Ecthyma gangrenosum is a rare, distinctive skin disorder associated with...

Researchers from Queen Elizabeth Hospital, Department of Intensive Care discuss findings in sepsis epidemiology.
July 2, 2009... Data detailed in 'Long-term survival of intensive care and hospital patient cohorts compared with the general Australian population: a relative survival approach' have been presented. "Long-term post-hospital survival of intensive care cohorts...

Research from V. Brousse et al broadens understanding of sickle cell anemia in children.
July 2, 2009... New investigation results, 'Does regular blood transfusion prevent progression of cerebrovascular lesions in children with sickle cell disease,' are detailed in a study published in Annals of Hematology. According to recent research from Paris,...

Research from A.S. Al-Mulhim and co-researchers provides new data on sickle cell anemia epidemiology.(Report)
July 2, 2009... Research findings, 'Laparoscopic cholecystectomy in 427 adults with sickle cell disease: a single-center experience,' are discussed in a new report. According to a study from Hofuf, Saudi Arabia, "Sickle cell disease (SCD) is common in the...

Study findings from Osaka City University, Department of Gastroenterology provide new insights into thrombocytopenic purpura therapy.(Clinical report)
July 2, 2009... Research findings, 'Long-term efficacy of Helicobacter pylori eradication in patients with idiopathic thrombocytopenic purpura: 7-year follow-up prospective study,' are discussed in a new report. "Helicobacter pylori eradication is useful for...

Reports from H. Nakajima and co-researchers add new data to research in vasculitis.
July 2, 2009... Fresh data on vasculitis are presented in the report 'Thrombotic eosinophilic vasculitis.' "Eosinophilic vasculitis is characterized by pruritic erythema, papules and angio-oedema. We report a case of thrombotic eosinophilic vasculitis with...

Studies from Cardiff University, Department of Haematology provide new data on von Willebrand disease.
July 2, 2009... New investigation results, 'C1584: effect on von Willebrand factor proteolysis and von Willebrand factor antigen levels,' are detailed in a study published in Acta Haematologica. "The present review provides a clearer picture of the effect of...

New acute leukaemia data have been reported by F. Bernard and co-authors.
July 2, 2009... According to recent research from Marseille, France, "We compared the impact of a conditioning regimen with BU (n = 16) or fractionated TBI (n = 42) on height growth during adolescence and final height (FH), in 58 adults transplanted for acute...

Study results from S.J. Horton et al provide new insights into acute leukemia.
July 2, 2009... According to recent research from London, the United Kingdom, "Chromosomal translocations involving 11q23 are frequent in infant acute leukemia and give rise to the formation of MLL fusion genes. The mechanism of leukemic transformation by...

New data from University of California illuminate research in adverse drug reactions.(Report)
July 2, 2009... According to recent research from the United States, "This study evaluated the safety, immunogenicity, and hemostatic effect of recombinant human Thrombin (rThrombin), in patients undergoing skin grafting for burns. This was a phase 2 multiple...

New allergies study findings have been reported from University of Utrecht.
July 2, 2009... According to recent research from Netherlands, "Medication errors occur regularly in surgical patients, especially due to transfer problems at the time of hospital admission. A method for decreasing the error rate is medication reconciliation...

Data on allograft rejection discussed by researchers at Kyoto Prefectural University, Medical Department.
July 2, 2009... According to a study from Kyoto, Japan, "It has been widely accepted that Th1- and IFN-gamma mediated immune responses are indispensable for corneal allograft rejection in BALB/c hosts. The present study was designed to determine the role of...

New research on aneurysm from G. Marrone and co-authors summarized.
July 2, 2009... "A female patient with severe pulmonary hypertension was admitted for lung transplant evaluation. As an incidental finding, the chest CT showed diffuse and dilated coronaries, not detected at previous echocardiography," scientists in Palermo,...

Researchers at Nara Medical University have published new data on aneurysm.(Report)
July 2, 2009... According to a study from Nara, Japan, "The purpose of this study was to evaluate the accuracy of centerline of flow (CLF) measurement for precise sizing of the Zenith AAA endovascular graft (Zenith) and to identify predictive factors of risk...

Study data from Baylor University update knowledge of aneurysm.
July 2, 2009... "Islet transplantation, an innovative treatment strategy for type 1 diabetes mellitus, is a relatively safe procedure, with less morbidity than pancreas transplantation. Vascular injuries have not been reported to date," investigators in the...

Research from N.W. Tsai et al broadens understanding of angiology.(Report)
July 2, 2009... According to recent research from Kaohsiung, Taiwan, "1. Platelets play a pivotal role during acute ischaemic stroke." "An increase in cytosolic Ca2+ concentrations ([Ca2+](i)) triggers intracellular signal transduction, leading to platelet...

Research from University of Alberta, Medical Department in the area of angiology published.
July 2, 2009... "The distribution of radiolabeled polyvinyl alcohol microspheres (PVAMs) when infused into the portal vein of domestic swine was investigated, with the purpose of assessing implications for pancreatic islet cell transplantation. PVAMs measuring...

Studies from J.H. Peregrin and colleagues provide new data on angioplasty.(Report)
July 2, 2009... According to recent research from Prague, Czech Republic, "This study is the report of a 37-year-old male with a transplanted kidney from a 3.5-year-old donor: the graft had two arteries transplanted with an aortic patch to an external iliac...

Reports outline angiotensins study results from Monash University.
July 2, 2009... According to recent research from Melbourne, Australia, "Eppel GA, Jacono DL, Shirai M, Umetani K, Evans RG, Pearson JT. Contrast angiography of the rat renal microcirculation in vivo using synchrotron radiation." "Am J Physiol Renal...

Research reports on angiotensins from Tulane University provide new insights.
July 2, 2009... According to a study from the United States, "Shao W, Seth DM, Navar LG. Augmentation of endogenous intrarenal angiotensin II levels in Val(5)-ANG II-infused rats." "Am J Physiol Renal Physiol 296: F1067-F1071, 2009. First published...

Researchers from Jilin University report on findings in angiotensins.
July 2, 2009... "1. Several groups have reported that melatonin produces a significant decrease in blood pressure in mammals and that pinealectomy in rats causes hypertension," scientists in Changchun, People's Republic of China report (see also Angiotensins)....

Research reports on aplastic anemia from R. Gurion and colleagues provide new insights.
July 2, 2009... According to recent research from Israel, "Immunosuppressive therapy is the treatment for aplastic anemia patients ineligible for transplantation. The role of hematopoietic growth factors as adjunct to treatment in these patients is unclear."...