Blood Weekly articles from July 2008

Blood Weekly archives from July 2008

New protocol streamlines therapy that makes more kidney transplants possible.
July 31, 2008... A new therapy developed at Cedars-Sinai Medical Center improves transplant rates and outcomes for patients awaiting living- and deceased-donor kidney transplantation, according to a study published in the July 17 issue of the New England...

Kidney transplants less successful at night.
July 31, 2008... Kidney transplants should be carried out during the day if possible. At least this is the conclusion suggested by a survey just published by urologists and internists at the University of Bonn (Transplantation Proceedings, vol. 40, p. 1341...

Researchers design model for automated, wearable artificial kidney.
July 31, 2008... Two researchers from UCLA and the Veterans Affairs Greater Los Angeles Healthcare System have developed a design for an automated, wearable artificial kidney, or AWAK, that avoids the complications patients often suffer with traditional...

Data on blood safety reported by researchers at University of Frankfurt.(Report)
July 31, 2008... According to recent research published in the journal Medical Education, "Medical students are at risk of occupational exposure to blood-borne viruses following needlestick injuries (NSIs) during medical school. The reporting of NSIs is an...

New research on cancer from University of Texas summarized.
July 31, 2008... "Few data exist on the etiology, presentation, prognosis, and management of fungal endophthalmitis (FE) in cancer patients. FE cases were identified by reviewing the ophthalmology reports and microbiology cultures of patients at The University...

Investigators at Taipei Veterans General Hospital publish new data on myelodysplastic syndrome.
July 31, 2008... According to recent research published in the Jcr - Journal of Clinical Rheumatology, "There have been 22 reported cases of Behcet disease associated with myelodysplastic syndrome. The majority of cases belong to incomplete types of Behcet...

Studies conducted at M. Yamasaki et al on necrosis recently published.
July 31, 2008... " To examine the effect of recombinant granulocyte colony-stimulating factor (G-CSF) on the number and function of neutrophils and on the histopathology of pulpal inflammation in normal and neutropenic rats. The effect of G-CSF on changes in...

Reports by T.G. Majczenko and co-researchers describe recent advances in neutropenia.
July 31, 2008... "Although a highly effective medication, the usage of clozapine is limited mostly by its 2.7% incidence of neutropenia. It is often a treatment of last resort for patients with severe psychiatric illnesses, and therefore often the only...

Studies from Harvard University have provided new data on neutropenia.
July 31, 2008... According to recent research from the United States, "Candida albicans fungemia in cancer patients is thought to develop from initial gastrointestinal (GI) colonization with subsequent translocation into the bloodstream after administration of...

Erasme University details research in sepsis.(Report)
July 31, 2008... According to a study from Brussels, Belgium, "C-reactive protein (CRP) may be a useful marker of sepsis but its use in the evaluation of response to therapy remains poorly defined. The aim of this study was to define the time course of CRP...

Investigators at National Institutes of Health have published new data on sepsis.
July 31, 2008... "Mortality from sepsis has remained high despite recent advances in supportive and targeted therapies. Toll-like receptors (TLRs) sense bacterial products and stimulate pathogenic innate immune responses," scientists in the United States report...

New sepsis study findings have been reported from University of Tennessee.
July 31, 2008... "Striking individual differences in severity of group A streptococcal (GAS) sepsis have been noted, even among patients infected with the same bacterial strain. We had provided evidence that HLA class II allelic variation contributes...

Study Shows Use of AdvanDx's PNA FISH(TM) Test was Associated with an 82% Reduction in Intensive Care Unit Mortality Rates from Staphylococcus aureus Bloodstream Infections.
July 31, 2008... AdvanDx announced that a new study shows use of AdvanDx's PNA FISH(TM) test was associated with an 82% reduction in mortality rates from S. aureus bloodstream infections in the intensive care unit (ICU), a 53% reduction in overall mortality...

Findings from Duke University in sickle cell anemia reported.
July 31, 2008... According to a study from the United States, "Up to 30% of adult patients with sickle cell disease (SCD) will develop pulmonary hypertension (pHTN), a complication associated with significant morbidity and mortality. To identify genetic factors...

Research from F. Zaja and colleagues has provided new data on thrombocytopenic purpura.
July 31, 2008... According to recent research from Udine, Italy, "Rituximab 375 mg/m(2) weekly for four weeks has significant activity in patients with immune thrombocytopenia. We evaluated the activity of lower dose rituximab (100 mg iv weekly for 4 weeks) in...

Research from Kobe University yields new findings on apoptosis cell biology.
July 31, 2008... Data detailed in 'Arsenic trioxide augments Chk2/p53-mediated apoptosis by inhibiting oncogenic Wip1 phosphatase' have been presented. "The oncogenic Wip1 phosphatase (PPM1D) is induced upon DNA damage in a p53-dependent manner and is required...

Research data from Royal College of Surgeons, Department of Clinical Microbiology update understanding of clinical microbiology.
July 31, 2008... New investigation results, 'Can we do better in controlling and preventing methicillin-resistant Staphylococcus aureus (MRSA) in the intensive care unit (ICU),' are detailed in a study published in European Journal of Clinical Microbiology &...

Researchers at University Medical Center have published new data on enzyme research.(Report)
July 31, 2008... New research, 'Tissue factor-independent effects of recombinant factor VIIa on hemostasis,' is the subject of a report. "The molecular mechanisms responsible for the hemostatic efficacy of recombinant activated factor VII (rFVIIa; NovoSeven,...

New findings reported from Emory University, Aflac Cancer Center and Blood Disorders Service describe advances in hemophilia.
July 31, 2008... A report, 'Safety update on recombinant factor VIIa in the treatment of congenital and acquired hemophilia,' is newly published data in Seminars In Hematology. "Recombinant activated factor VII (rFVIIa) appears to be safe when used for its...

Autonoma University reports research in hemophilia therapy.(Report)
July 31, 2008... Research findings, 'Orthopedic management in hemophilia: a Spanish outlook,' are discussed in a new report. "Hematologists are of the opinion that orthopedic surgeons will eventually not be required in the clinical management of patients with...

New life sciences study findings recently were reported by researchers at Children's Hospital.(Report)
July 31, 2008... Research findings, 'A prospective, observational, post-approval registry of inhibitor patients treated with multiple or single doses of recombinant activated factor VII,' are discussed in a new report. According to a study from Marseille,...

Research from McGill University, Lady Davis Institute for Medical Research in the area of life sciences published.(Report)
July 31, 2008... Research findings, 'Arsenic trioxide decreases AKT protein in a caspase-dependent manner,' are discussed in a new report. "Arsenic trioxide (As2O3) is used clinically to treat acute promyelocytic leukemia but is less successful in other...

Seirei Hamamatsu General Hospital, Department of Pediatrics describes research in purpura.
July 31, 2008... Scientists discuss in 'Pulmonary hemorrhage associated with Henoch-Schonlein purpura in a child' new findings in purpura. According to recent research published in the journal Clinical Rheumatology, "Swelling of the right ankle and purpura on...

Research on acute leukemia detailed by L. Fouillard and co-authors.
July 31, 2008... According to recent research from Paris, France, " The possibility of performing syngeneic hematopoietic stem cell transplantation is rare and there are concerns about the absence of a graft-versus-leukemia effect following such a strategy. We...

Research from University of Basel in the area of acute myeloid leukemia published.
July 31, 2008... "We have studied a patient with acute myeloid leukemia (AML) and t(10;11)(q23; p15) as the sole cytogenetic abnormality. Molecular analysis revealed a translocation involving nucleoporin 98 (NUP98) fused to the DNA-binding domain of the...

Studies from Sichuan University yield new data on aneurysm.
July 31, 2008... "Intracranial aneurysm (ICA) is a common condition but with a high mortality rate when rupture occurs. The treatment of ruptured or unruptured ICA, especially with an endovascular approach, has been evolving rapidly," investigators in Chengdu,...

Studies from Erasmus University provide new data on angiology.
July 31, 2008... According to recent research published in the journal Angiology, "The effect of age and blood pressure on the carotid and the radial artery distensibilities was investigated. Patients referred to the outpatient clinic of the Department of...

New findings in angiotensins described from Uppsala University.(Report)
July 31, 2008... "The aim of this study was to investigate the effect of the plasma concentration of irbesartan, a specific angiotensin II type 1 receptor (AT1R) antagonist, and the blood pressure response in relation to AT1R gene polymorphisms. Plasma...

Research from University of Helsinki in the area of angiotensins described.
July 31, 2008... "Evaluation of relation between blood pressure (BP) and intraocular pressure (IOP) in two hypertensive rat strains: spontaneously hypertensive rats (SHR) and double transgenic (dTGR) (harboring human renin and angiotensinogen genes) rats, and...

Study results from University of Jaen broaden understanding of angiotensins.
July 31, 2008... "Men are at greater risk of cardiovascular and renal diseases than women. Several hypertensive rat models also exhibit gender differences in blood pressure," scientists writing in the International Journal of Andrology report (see also...

Study findings from Astellas Pharma, Inc. provide new insights into antifungals.
July 31, 2008... "Further optimization of the potent antifungal activity of side chain analogs of the natural product FR901379 led to the discovery of compound 8 with an excellent, well-balanced pro. le," researchers in Kashima, Japan report (see also...

Scientists at Hallym University detail research in apoptosis.(Report)
July 31, 2008... According to a study from South Korea, "CD7, one of the galectin-1 receptors, has crucial roles in galectin-1-mediated apoptosis of activated T-cells and T-lymphoma progression in peripheral tissues. In this study, we showed that CD7 promoter...

New arteriovenous malformation findings from S.K. Cho and co-researchers published.(Report)
July 31, 2008... In this recently published article, scientists in Seoul, South Korea conducted a study "To assess retrospectively the treatment results of ethanol embolization of peripheral arteriovenous malformations (AVMs) with a dominant outflow vein...

Study results from J. Rovensky and colleagues broaden understanding of arthritis.
July 31, 2008... According to recent research published in the Israel Medical Association Journal, "In both adjuvant arthritis and rheumatoid arthritis, edema and inflammation appear in synovial joints. Edema or effusion reflects an imbalance in lymph...

Reports from Malmo University highlight recent research in atherosclerosis.
July 31, 2008... According to a study from Malmo, Sweden, "Lysophosphatidylcholine (LPC) has been attributed a pro-inflammatory role in atherosclerosis. Cell culture studies have identified stimulation of cytokine expression and chemotaxis by micromolar (mc M)...

Research data from University of Texas update understanding of autism.
July 31, 2008... According to recent research from the United States, "Neuroligins (NLs) are postsynaptic cell-adhesion molecules that are implicated in humans in autism spectrum disorders because the genes encoding NL3 and NL4 are mutated in rare cases of...

New autoimmune disease study findings recently were published by researchers at Medical University of Vienna.
July 31, 2008... "To determine a possible causative association between autoimmunity and premature ovarian ageing (POA), 394 women undergoing IVF at an academically affiliated private IVF centre were retrospectively evaluated for the presence of...

Reports from Queen Elizabeth Hospital describe recent advances in autoimmune disease.
July 31, 2008... According to a study from Birmingham, the United Kingdom, "Liver transplantation remains an effective treatment for those with end-stage disease and with intractable liver-related symptoms. The shortage of organs for transplantation has...

Research from Kobe University, Medical Department yields new findings on azoospermia.(Report)
July 31, 2008... According to recent research from Kobe, Japan, "To investigate the metabolic syndrome and sex hormones in patients with Klinefelter's syndrome (KFS), 46XY men with nonobstructive azoospermia (NOA), and an age-matched obstructive azoospermia...

Research reports on B-cell lymphoma from University of Miami provide new insights.
July 31, 2008... According to recent research published in the journal Blood, "Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease characterized by variable clinical outcomes. Outcome prediction at the time of diagnosis is of paramount importance."...

Research results from G.N. Papaliodis and co-authors update knowledge of B-cell lymphoma.
July 31, 2008... In this recent report published in the journal Ocular Immunology and Inflammation, researchers in the United States conducted a study "To report a case of a pseudo-hypopyon as the presentation for recurrent B-cell lymphoma. Case report. Case...

Researchers from Indiana University, Medical Department publish findings in B-cell lymphoma.
July 31, 2008... According to recent research from the United States, "Natural killer T (NKT) cells are a T-cell subpopulation known to possess immunoregulatory functions and recognize CD1d molecules. The majority of NKT cells express an invariant T-cell...

Report summarizes bioengineering study findings from Drexel University, Medical Department.
July 31, 2008... According to recent research published in the Journal of Biological Chemistry, "Interleukin (IL)-5 exerts hematopoietic functions through binding to the IL-5 receptor subunits, alpha and beta c. Specific assembly steps of full-length subunits...

New research on biomedicine from University of London, King's College summarized.(Report)
July 31, 2008... "in this paper we offer some reflections on embryos in the biomedical worlds of embryonic stem cells (ESC) and pre-implantation genetic diagnosis (PGD)," scientists in London, the United Kingdom report (see also Biomedicine). "We draw upon...

New blood pressure study findings have been reported by S.S.M. Chen and co-researchers.
July 31, 2008... In this recent report, researchers in London, the United Kingdom conducted a study "To determine the relation of ambulatory systolic blood pressure to aortic obstruction and more extensive vascular dysfunction, assessed by central aortic,...

Reports summarize blood pressure research from J.B. Joensen and co-authors.(Report)
July 31, 2008... "This study assesses measurement variation in the measurement of ankle systolic blood pressure (ABP) when measured with Doppler ultrasound and with the strain gauge method. Ninety-seven patients were included," researchers in Copenhagen,...

Research from J.Y.A. Foo and co-researchers in the area of blood pressure described.(Report)
July 31, 2008... "Ankle brachial index is useful in monitoring the pathogenesis of peripheral arterial occlusive diseases. Sphygmomanometer is the standard instrument widely used but frequent prolonged monitoring can be less comfortable for patients,"...

New bone marrow research from University of Minnesota outlined.(Report)
July 31, 2008... According to recent research from the United States, "Myeloablative conditioning results in thymic epithelial cell (TEC) injury, slow T-cell reconstitution, and a high risk of opportunistic infections. Keratinocyte growth factor (KGF)...

Studies from Medical University of Innsbruck in the area of bone research published.
July 31, 2008... "Medical implants are increasingly often inserted into bone of frail patients, who are advanced in years. Due to age, severe trauma or pathology-related bone changes, osseous healing at the implant site is frequently limited," scientists in...

Studies from M.A. Fanelli and colleagues reveal new findings on breast cancer.
July 31, 2008... According to a study from Mendoza, Argentina, "The cadherin-catenin proteins have in common with heat shock proteins (HSP) the capacity to bind/interact proteins of other classes. Moreover, there are common molecular pathways that connect the...

Researchers from INSERM report recent findings in bronchiolitis.
July 31, 2008... According to a study from France, "Obliterative bronchiolitis (OB) is the major cause of long-term lung allograft loss resulting from an unclear immune process occurring in the absence of the donor's immune cells. The present authors...

Study findings from University of London provide new insights into cancer.
July 31, 2008... "There has been a substantially increased interest in biomedical research impact assessment over the past 5 years. This can be studied by a number of methods, but its influence on clinical guidelines must rank as one of the most important,"...

Investigators at University of Alabama target cardiology.(Report)
July 31, 2008... According to a study from the United States, "Extracorporeal photopheresis (ECP) is used to treat recurrent severe rejection in clinical heart and lung recipients. The mechanisms of the salutary effects of ECP are poorly understood, but appear...

Data on cardiovascular disease reported by researchers at Johns Hopkins University.
July 31, 2008... According to recent research from the United States, "Depression accelerates the development and progression of cardiovascular disease and confers an increased risk of mortality. Platelets share biochemical similarity with the central nervous...

Studies from University of Plymouth reveal new findings on cardiovascular disease.
July 31, 2008... According to recent research from Plymouth, the United Kingdom, "Nitric oxide (NO), produced by the polymorphic endothelial nitric oxide synthase (NOS3), plays an important role in endothelial function. The aim was to determine the effect of...

Data on chronic lymphocytic leukemia discussed by researchers at University of Turin, Medical Department.(Report)
July 31, 2008... According to recent research from Turin, Italy, "CD38 rules proliferation signals in chronic lymphocytic leukemia (CLL) cells, suggesting that the molecule is not merely a prognostic marker but also a key element in the pathogenetic network...

Study results from D. Crowtherswanepoel et al provide new insights into chronic lymphocytic leukemia.
July 31, 2008... "To address the proposition that familial B-cell chronic lymphocytic leukemia (CLL) may exhibit a more restricted phenotype than sporadic CLL with respect to immunoglobulin gene usage or ontogenic development, we compared immunoglobulin (Ig)...

New circulation research findings from Columbus Children's Hospital published.(Report)
July 31, 2008... According to a study from the United States, "Despite increased interest in complications within pediatric cardiology, the domain of imaging-related diagnostic errors has received little attention. We developed a new taxonomy for diagnostic...

New clinical trial research research has been reported by J.M. Calvoromero et al.
July 31, 2008... In this recent study, researchers in Caceres, Spain conducted a study "To study the adverse outcomes and its predictors during anticoagulant therapy in patients with venous thromboembolic disease (VTD) from a rural population. This is a...

Researchers from Monash University detail findings in clostridium.(Report)
July 31, 2008... "Reduced tissue perfusion leading to tissue ischemia is a central component of the pathogenesis of myonecrosis caused by Clostridium perfringens. The C. perfringens alpha-toxin has been shown capable of inducing these changes, but its potential...

Reports from U. Tebbe et al highlight recent research in coagulation.
July 31, 2008... According to recent research from Detmold, Germany, " Patients with persistent atrial fibrillation (AF) scheduled for electrical cardioversion need immediate anticoagulation. Unfractionated heparin (UFH) is often used for early anticoagulation...

Research from T. Ebner and co-authors provides new data about coagulation.
July 31, 2008... "Assessment of oocyte maturity and quality (morphological appearance) at the time of retrieval is difficult as the egg is obscured by a large cumulus mass that hinders adequate scoring. Since no data are available on the possible relationship...

Research on compression fractures reported by scientists at University of Texas.
July 31, 2008... In this recent report, researchers in the United States conducted a study "To describe vertebroplasty and kyphoplasty, which are relatively new techniques used to treat painful vertebral compression fractures. Setting Patients. This article...

Research from Shanghai Jiao Tong University provides new data about cytometry.
July 31, 2008... "In vivo studies showed that dendritic cell (DC) dysfunction occurred in tumor microenvironment. As tumors were composed of many kinds of cells, the direct effects of tumor cells on immature DCs (imDCs) are needed for further studies in vitro,"...

Data on deep vein thrombosis published by M.R. Lassen and colleagues.
July 31, 2008... "We investigated the efficacy of rivaroxaban, an orally active direct factor Xa inhibitor, in preventing venous thrombosis after total knee arthroplasty. In this randomized, double-blind trial, 2531 patients who were to undergo total knee...

Findings from Sahlgrenska University broaden understanding of deep vein thrombosis.(Clinical report)
July 31, 2008... According to recent research from Gothenburg, Sweden, "This phase 3 trial compared the efficacy and safety of rivaroxaban, an oral direct inhibitor of factor Xa, with those of enoxaparin for extended thromboprophylaxis in patients undergoing...

Research from I. Saeed et al has provided new information about depression.(Survey)
July 31, 2008... According to a study from London, the United Kingdom, "Health-related quality of life (HRQOL) is an important. measure of outcome that is known to improve after cardiac transplantation, and some studies have suggested that the HRQOL approaches...

Research from L.C. Weng and co-researchers yields new findings on depression.(Survey)
July 31, 2008... "The aim of this study was to examine the effect of self-efficacy on depression and to consider the mediating effect of self-care behaviour. Depression is a problem for kidney transplant recipients and can compromise their quality of life,"...

New diabetes study findings have been reported from University of Tsukuba.
July 31, 2008... "Congenital nephrogenic diabetes insipidus (NDI) is characterised by an inability to concentrateurine despite normal or elevated plasma levels of the antidiuretic hormone arginine vasopressin. We report a Japanese extended family with NDI...

Studies from C.B. Tighe and colleagues reveal new findings on diabetes.
July 31, 2008... "Adhesive capsulitis is characterized by a progressive and painful loss of shoulder motion of unknown etiology. Previous studies have found the prevalence of adhesive capsulitis to be slightly greater than 2% in the general population,"...

Technical University details research in diabetes.(Report)
July 31, 2008... According to recent research published in the journal Diabetes Technology & Therapeutics, "This study evaluates the quality of care of a pharmacist-managed diabetes clinic focused on an indigent population and compares that quality of care to...

Research from University of Maryland, Medical Department reveals new findings on diabetes management.(Clinical report)
July 31, 2008... According to a study from the United States, "Less than 63% of individuals with diabetes meet professional guidelines target of hemoglobin A1c "Secondary aims examined health care provider (HCP) adherence to prescribing guidelines and...

New diabetic nephropathy study results reported from S. Chang et al.(Report)
July 31, 2008... According to a study from the United States, "Reduced nephron number is hypothesized to be a risk factor for chronic kidney disease and hypertension. Whether reduced nephron number accelerates the early stages of diabetic nephropathy is...

Research from University of Sussex has provided new information about DNA research.
July 31, 2008... "Several human disorders mutated in core components of the major DNA double-strand break (DSB) repair pathway, non-homologous end joining (NHEJ), have been described. Cell lines from these patients are characterized by sensitivity to...

Recent studies from University of Alabama add new data to drug delivery.
July 31, 2008... "Although polymers and hydrogels; are used successfully in biomedical applications, including implants and drug delivery devices, smaller molecular weight oligomers, such as those investigated here, have not been extensively studied in vivo....

Research results from B.C. Cavalcanti and colleagues update understanding of drug development.
July 31, 2008... According to recent research published in the journal Comparative Biochemistry and Physiology C - Toxicology & Pharmacology, "Marine sponges belonging to the order Haplosclerida are one of the more prolific sources of new natural products...

Research from Kyoto University, Medical Department in the area of drug resistance described.(Report)
July 31, 2008... " The potential influence of the multidrug resistance 1 (MDR1) gene and the cytochrome P450 (CYP) genes, CYP3A4 and CYP3A5, on the oral clearance (CL/F) of tacrolimus in adult living-donor liver transplant patients was examined. Furthermore,...

Findings from A.M.S. Assreuy and co-authors broaden understanding of edema.
July 31, 2008... "Sulfated-polysaccharides are exploited as antithrombotic and anticoagulant agents and suggested to be immunostimulants. The sulfated-polysaccharide isolated from the red-marine-algae Champia feldmannii (Cf-PLS) was purified by ion exchange...

Research from G.N. Allahbadia et al broadens understanding of embryo transfer.
July 31, 2008... "Transient motion of embryo transfer-associated antibubbles was observed. This prospective study was performed to determine if this antibubble movement can predict a successful outcome," scientists in Bombay, India report (see also Embryo...

Scientists at Hadassah University target encephalomyelitis.
July 31, 2008... In this recent report, researchers in Jerusalem, Israel conducted a study "To investigate the therapeutic potential of mesenchymal stromal cells (MSCs) in the chronic model of experimental autoimmune encephalomyelitis (EAE). Mesenchymal stromal...

Findings from University of Navarra in enzyme research reported.
July 31, 2008... According to recent research from Pamplona, Spain, " A soluble form of endothelial cell protein C receptor (sEPCR) is generated by shedding of the cellular form. sEPCR binds to protein C and factor VIIa and inhibits both the activation of...

Findings in enzyme research reported from Medical University of Vienna.
July 31, 2008... "Platelet-derived growth factor isoforms and components of the plasminogen activator system are expressed at higher levels during periodontal regeneration. Recombinant platelet-derived growth factor-BB is approved for the treatment of...

New enzyme research research from M.A. Rubtsov et al outlined.
July 31, 2008... According to recent research from Russia, "The translocation t(8;21)(q22;q22) affecting AML1 and ETO genes is known to be one of the frequent chromosome translocations in acute myeloid leukemia. But no data have been available up to date...

Research reports on enzyme research from Medical College provide new insights.(Report)
July 31, 2008... "It has been shown that the polymorphisms of Methylenetetrahydrofolate reductase (MTHFR) gene are associated with susceptibility to several disorders including hyperhomocysteinemia, vascular disease, birth defect, and certain cancers, and...