Blood Weekly articles from July 2003

Blood Weekly archives from July 2003

Low molecular weight heparin safe for hepatic VOD prevention.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Low molecular weight heparin (LMWH) is safe as prophylaxis against hepatic veno-occlusive disease in stem cell transplant recipients, researchers in Canada say....

NK-92 autograft purging effective.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Cytotoxic cells can be used for ex vivo purging of autologous hematopoietic stem cell grafts, researchers in the United States report. "Although...

New class of human stem cells discovered.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- Scientists with University Health Network, University of Toronto, have discovered a new class of human stem cells that rapidly grow when implanted in the bone marrow of mice. The findings, reported...

Prostaglandin E-2 induces osteoclast differentiation of hematopoietic bone marrow cells.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- Prostaglandin E-2 (PGE2) induces osteoclast differentiation of hematopoietic bone marrow cells. PGE2 "is a known bone absorbing agent that acts on osteoblasts to facilitate osteoclastogenesis by...

Wnt signaling involved in hematopoietic cell self-renewal.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- Wnt signaling plays a key role in the self-renewal of hematopoietic stem cells (HSCs). These cells "have the ability to renew themselves and to give rise to all lineages of the blood; however, the...

Novel myeloid-like NK cell progenitor identified.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- A novel myeloid-like NK cell progenitor has been identified in umbilical cord blood. "Natural killer (NK) cell differentiation from pluripotent CD34+ human hematopoietic stem cells or oligopotent...

HAART appears to have caused biological shift towards more treatable disease.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- Since the use of highly active antiretroviral therapy (HAART) to treat HIV, physicians have seen an improvement in the prognosis for patients with AIDS-related lymphomas. Researchers from the U.S....

Unrelated stem cell grafts improve survival for children with high recurrence risk.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- Unrelated stem cell grafts improve survival chances for children with high-risk acute lymphoblastic leukemia (ALL). "Allogeneic stem cell transplantation (SCT) is frequently considered as treatment...

More cytokines are produced by circulating lymphoid and myeloid cells in AML.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- Acute myelogenous leukemia patients have blood cells that produce more cytokines than normal cells. According to recent research from England, "A simple assay was developed to assess the potential...

Gemtuzumab ozogamicin may be effective for pediatric patients.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- Gemtuzumab ozogamicin (GO) can be beneficial for pediatric leukemia patients. This agent "was developed to treat CD33+ acute myeloid leukemia (AML)," researchers in the Netherlands explained....

Alternatives to human embryonic stem cells promoted.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- Scientists told a U.S. Senate panel on June 12, 2003, that alternatives to human embryonic stem cells, including adult stem cell treatment and umbilical cord blood transplants, have had proven success...

Serratia species have multiple mechanisms, including unique beta-lactamases.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- Potential pathogen strains of Serratia are found to be naturally resistant to many antibiotics and to produce some unique beta-lactamases. According to recent research published in the Journal of...

Leukocyte depletion prior to storage sometimes will not filter well.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- Not all blood behaves the same in attempts to store autologous blood depleted of leukocytes; sickle cell anemia is an identifiable reason in some cases. According to a study from Germany, "New...

"Immortalized" cells enable researchers to grow human arteries.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- In a combination of bioengineering and cancer research, a team of Duke University Medical Center researchers has made the first arteries from non-embryonic tissues in the laboratory, an important step...

Glycine-treated products can be stored briefly and used after opening.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- Some glycine-treated blood products can be stored briefly and used after opening. Scientists in Japan "evaluated microbial viability in preparations packaged for single use only which mandate that...

FDA issues 510(k) clearance for new blood banking system.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- Ortho-Clinical Diagnostics announced that its Micro Typing Systems subsidiary received 510(k) clearance from the U.S. Food and Drug Administration (FDA) to begin marketing the Ortho ProVue, a new, fully...

Novel flow cytometry assay can measure lymphocyte levels in RBC-contaminated samples.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- A novel flow cytometry assay can measure lymphocyte levels in samples contaminated with red blood cells. "Determination of lymphocyte subpopulations is usually carried out by flow cytometry using...

BMT can be successful in subjects with mental disorders.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- Bone marrow transplantation can be successful in subjects with mental disorders. "Bone marrow transplantation (BMT) is a critical treatment of malignant illnesses including leukemia and others....

Survival not substantively affected by depressed mood or other psychopathology.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- Survival is not substantively affected by depressed mood or other psychopathology. According to a study from the United States, "An electronic database search identified 15 studies of psychosocial...

IV infusions of human umbilical cord blood stem cells benefit rodents with ALS.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- Stem cells derived from human umbilical cord blood (HUCB) migrate to damaged areas in the brain and spinal cord caused by disease or injury and provide some therapeutic benefit, according to results of...

Plasmapheresis was used to sucessfully lower the titers of autoantibodies.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- Plasmapheresis was used to lower the titers of autoantibodies to treat bullous pemphigoid. Recent research published in the Journal of Dermatology "reports a case of bullous pemphigoid successfully...

EntreMed and Corvas scientists identify new cancer target.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- EntreMed, Inc., (ENMD) and Corvas International, Inc., (CVAS) published preclinical findings demonstrating that the growth of primary and metastatic tumors in animal models was prevented when scientists...

The first case of primary colorectal T-cell lymphoma is reported.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- The first case of primary colorectal T-cell lymphoma is reported. According to published research from Japan, "We report here a case of primary colorectal T-cell lymphoma in a 49-year-old man....

Novel liquid occlusive effective for wound dressing.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- A novel liquid wound dressing can help maintain hemostasis and prevent infection. Researchers in the United States "evaluated a novel octylcyanoacrylate-based liquid occlusive dressing for...

Capillary electrophoresis immunoassay is comparable to chemiluminescence.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- Capillary electrophoresis immunoassay is comparable to chemiluminescent assay for estradiol serology. According to a study from People's Republic of China, "A rapid and sensitive capillary...

Private placement funds will further develop stem cell technology.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- A.I. Software, Inc., (ASOW) announced that a private placement of securities has raised gross proceeds of $861,500, which will be used to help fund continuing development of its stem cell expansion...

Blood safety company closes new financing.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- Blood safety products company V.I. Technologies, Inc. (NASDAQ:VITX) announced that it had completed the closing and funding of its recent equity financing. This included the Pall Corporation...

Griscelli syndrome without hemophagocytosis occurs with a new Rab27A mutation.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- A new deletion in Rab27A gene produces a phenotype of Griscelli syndrome without hemophagocytosis but with apparent partial albinism and Elejalde immunodeficiency syndrome characteristics. ...

Incidence of sepsis could be underestimated in newborns.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- Authors of a research letter in the June 6, 2003, issue of The Lancet suggest that the incidence of disease caused by group B streptococcal infection in babies is underestimated because the current gold...

Dual cancers can coexist: Chronic lymphocytic leukemia and mantle cell lymphoma.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- A patient had dual cancers: chronic lymphocytic leukemia in blood and mantle cell lymphoma in lymph nodes. According to recent research from Portugal, "We report a case of a patient with 2 B-cell...

Patients with chronic hepatitis C and mixed cryoglobulinemia undergo apheresis.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- Patients with chronic hepatitis C and mixed cryoglobulinemia have undergone immunosorbent apheresis. "In this short-term open label clinical pilot study, conducted at one center, the immune complex...

Phase I data on suberoylanilide hydroxamic acid presented.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- Aton Pharma, Inc., announced that the abstract "Clinical Experience of the Histone Deacetylase Inhibitor Suberoylanilide Hydroxamic Acid (SAHA) in Heavily Pre-Treated Patients with Hematological...

Thrombospondin-2 is required for megakaryocyte formation and function.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- Thrombospondin-2 is required for megakaryocyte formation and function. According to published research from the United States, "mice that lack the matricellular angiogenesis inhibitor,...

Tissue factor messenger RNA is higher in cancer and hypercoagulable diseases.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- The level of tissue factor in white blood cells is high in intravascular coagulation and several other diseases. "In a preliminary study, we have demonstrated that tissue factor (TF) is...

New study shows patients at risk for kidney disease may benefit from new therapy.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- Data presented at the 2003 American Transplant Congress showed that the conversion of patients at risk for the development of Chronic Renal Allograft Failure (CRAF) from cyclosporine to Prograf...

Delayed graft function worsens with reduced pressure reperfusion.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- Delayed graft function appears to be worsened by reduced pressure reperfusion and improved by rinsing with Carolina rinse solution prior to reperfusion. "Despite extensive efforts in the fields of...

Microchimerism can be avoided by perfusing out donor kidney lymphocytes.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- Microchimerism can be avoided by perfusing out donor kidney lymphocytes prior to transplantation. According to recent research from Norway, "After solid organ transplantation, donor lymphocytes...

Analysis: Neoral improves graft survival in living-donor transplant patients.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- Novartis Pharmaceuticals Corp. (NVS) reported that the long-term survival rates of a transplanted kidney from a living donor appear to be significantly greater with cyclosporine-based immunosuppressive...

Breastfeeding does not protect children from acute lymphocytic leukemia.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- Breastfeeding does not protect children from acute lymphocytic leukemia. According to recent research from England, "Matched pair analysis relating to 3376 mothers of children who died of cancer...

Eosinophilia counts have limitations as liver graft rejection screening tools.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- Eosinophilia counts have limitations as liver graft rejection screening tools. "This study evaluates the predictive value of the blood eosinophil count in the diagnosis of acute cellular rejection,...

Epstein-Barr virus-associated T-cell lymphoma can develop after renal transplant.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- Epstein-Barr virus-associated T-cell lymphoma can develop after renal transplant. According to recent research published in the Journal of Korean Medical Science, "The incidence of...

Initial clinical data reported from phase I/II trial of GVAX vaccine.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- Cell Genesys, Inc., (CEGE) reported initial clinical data from a phase I/II trial of GVAX cancer vaccine for multiple myeloma, a type of bone marrow cancer, as well as positive interim results on a...

Some patients have autoreactive T cells to an acetylcholine receptor subunit.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- Some myasthenia gravis patients with late onset and thymoma have autoreactive T cells to an acetylcholine receptor subunit. "In vitro T cell proliferative response to an alternative splicing...

Motor nerve cell findings may yield treatments for spinal cord injury, disease.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- Manufacturing motor nerve cells may someday be possible to help restore function in victims of spinal cord injury or such diseases of motion as Parkinson's and Lou Gehrig's disease or post-polio...

Endothelial cell inflammatory response to endotoxin needs actin polymerization.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- Actin polymerization to produce stress fibers, ICAM-I and IL-8 expression are endothelial cell proinflammatory activities when challenged with endotoxin. "Endotoxin-induced intercellular adhesion...

BEAM may cause more gastrointestinal toxicity than BEAC.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- The BEAM chemotherapy regimen may cause more gastrointestinal toxicity than the BEAC regimen. "High-dose chemotherapy supported by autologous stem cell transplantation is widely used in patients...

Efforts to reduce viral hepatitis transmission by health workers fall short.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- Efforts to reduce viral hepatitis transmission by health workers fall short in Germany. "Transmission of HBV and HCV from people who work in medical professions to their patients is still an...

Bartonella bacilliformis IalB is expressed with low pH and temperature.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- The expression of IalB is altered following the environmental clues of pH and temperature change, but not in response to oxidative stress or hemin change, and relates to vector-host passage. ...

Study finds clopidogrel not effective in certain patients.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- Researchers at Sinai Hospital of Baltimore have discovered that patients with overreactive platelets, which may be a risk factor for clotting, do not always respond to current drugs designed to decrease...

Tolerization appears to happen after what would seem to be a normal Th1 response.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- Tolerization induced by pre-transplant blood transfusion happens after what would appear to be a normal Th1 response. "Donor-specific blood transfusion (DSBT) promotes graft acceptance in certain...

Stem cell antigen-1 reveals information about pulmonary vascular endothelium.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- Stem cell antigen-1 reveals information about pulmonary vascular endothelium. "Although the function of the cell surface protein stem cell antigen-1 (Sca-1) has not been identified, expression of...

TT virus group 1 variants prevail among kidney transplant recipients.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- TT virus group 1 variants prevail among kidney transplant recipients. "TT virus (TTV) genogroup 1 infection has an increased prevalence in solid organ transplant recipients. In this study, the...

NaPro's gene editing demonstrates gene alteration in human cells.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- NaPro BioTherapeutics, Inc., (NPRO) announced the development of a clinically applicable protocol to achieve specific gene alteration in human hematopoietic stem/progenitor cells. These results,...

Complement anaphylatoxin C3a involved in homing to bone marrow.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- The complement anaphylatoxin C3a plays a key role in hematopoietic stem cell homing to bone marrow. "Complement has recently been implicated in developmental pathways and noninflammatory...

Embryonic cells can differentiate into transplantable hepatocytes.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- Clinically useful hepatocytes can be derived from embryonic stem cells. Embyonic cells "provide a unique source for tissue regeneration," scientists in Japan explained. H. Yamamoto and...

Hydrostatic pressure can enhance mesenchymal progenitor cell differentiation.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- Hydrostatic pressure can be used to enhance mesenchymal progenitor cell differentiation in vitro. "Much attention has been given to the influences of bioactive factors on mesenchymal progenitor...

Neural stem cells take a step closer to the clinic.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- Scientists working with cells that may someday be used to replace diseased or damaged cells in the brain have taken neural stem cell technology a key step closer to the clinic. Writing in the June...

Spermatogonial cell expansion possible.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- Spermatogonial stem cells can be expanded ex vivo. "Spermatogenesis is dependent on a small population of stem cells," scientists in Japan explained. "Although stem cells are believed to expand...

Tyrosine kinase activity increased in leukemic mice.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- Tyrosine kinase activity is increased in stem cells from leukemic mice. "Tyrosine kinase has an important role with regard to self-renewal and as a comitogen in the movement of stem cells out of the...

Antigen-primed CD8 cells can cause graft failure without major effector pathways.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- Antigen-primed cytotoxic T cells can cause marrow graft rejection even in the absence of major effector pathways. "Engraftment failure following allogeneic bone marrow (BM) transplantation is of...

Early post-transplant proteinuria may mark glomerular vasculopathy.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- Proteinuria developing shortly after stem cell transplantation may mark glomerular vasculopathy. According to published research from Japan, "a one-year-old boy with hemophagocytic...

Fibrin gel could act as delivery system for mesenchymal stem cells.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- A novel fibrin gel could be used to deliver mesenchymal stem cells to bone sites. "A potential therapy to enhance healing of bone tissue is to deliver isolated mesenchymal stem cells (MSCs) to the...

Human hematopoietic cells can contribute to liver recovery.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- Human hematopoietic cells may be useful for treating liver damage. "Rodent bone marrow cells can contribute to liver. If these findings are applicable to humans, marrow stem cells could...

Interleukin-7 may improve post-transplant T-cell recovery.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- Interleukin-7 may improve T-cell recovery after hematopoietic stem cell transplantation. "In mice, interleukin-7 (IL-7) hastens T-cell reconstitution and might cause autoimmune diseases, lymphoma,...

Aspirin may be better preventive than ticlopidine in African-American patients.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- Aspirin appears to be the better treatment than the antiplatelet drug ticlopidine for preventing recurrent stroke in black patients, according to a study in the Journal of the American Medical...

Study finds intravenous immunoglobulin may induce stroke in some patients.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- Researchers at Wake Forest University School of Medicine have discovered that a relatively common treatment for a diverse group of diseases may induce stroke in a small percentage of the population. ...

Second generation fibrin glue improves hemostasis after throat surgery.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- A modern fibrin glue enables improved hemostatic control after throat surgery. Researchers in Israel "performed a prospective randomized study in 179 patients to examine the second-generation...

LifeNet releases Optium, a demineralized bone matrix.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- LifeNet, a nonprofit tissue banking system, has added Optium to its product offerings for hospitals, patients, and surgeons across the United States. Optium is a demineralized bone matrix. ...

Faster method for growing adult stem cells for bone regeneration wins award.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- A new method for using adult stem cells for bone or other tissue regeneration without having to go through the intermediate step of expanding the number of cells in tissue culture has won a Kaye...

Bone marrow can enhance hydroxyapatite-induced bone healing.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- Bone marrow can be used to enhance hydroxyapatite-induced bone healing. "Hydroxyapatite is a synthetic bone graft, which is used for the treatment of bone defects and nonunions," researchers in the...

Risks associated with transfusions in Canada characterized.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- The odds of acquiring transfusion-related conditions in Canada have been determined. Researchers in Canada produced "a comprehensive review of risks associated with allogeneic red blood cell and...

Final results of phase IIa kidney transplant trial announced.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- Isotechnika, Inc., announced that the company presented the final results of its phase IIa kidney transplant study at the American Transplant Congress in Washington, DC. Designed to evaluate...

Relapse of malignancy after bone marrow transplant is treatable with lymphocytes.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- Donor lymphocyte infusion is now being used to treat hematological malignancy following bone marrow transplant and relapse. According to recent research published in the Saudi Medical Journal, "The...

Study: Thymoglobulin cut rejection rate by nearly 50%.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- SangStat Medical Corp. (SANG) presented final results from its transplant study that showed Thymoglobulin cut the rate of acute rejection by nearly 50% in cadaveric kidney transplant patients compared...

Food and Drug Administration says screening tests will be ready to protect blood supply.
July 3, 2003... 2003 JUL 3 - (NewsRx.com & NewsRx.net) -- Gearing up for another season of West Nile virus, federal officials in the U.S. said on June 9, 2003, that two screening tests to protect the country's blood supply from the disease should be available...

Peptide-pulsed dendritic cells produce little clinical effect.
July 10, 2003... 2003 JUL 10 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - A therapeutic leukemia vaccine prototype based on peptide-pulsed dendritic cells (DCs) has little if any clinical effect, researchers in Japan say. ...

CD34+ enrichment doesn't improve elutriated graft outcome in non-cancer patients.
July 10, 2003... 2003 JUL 10 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - CD34+ cell enrichment does not improve the success rate of elutriated stem cell allografts for non-cancer patients, researchers warn. "T-cell depletion of...

Stem cell allografts effective after reduced-intensity conditioning.
July 10, 2003... 2003 JUL 10 - (NewsRx.com & NewsRx.net) -- Hematopoietic stem cell allografts remain effective against chronic lymphocytic leukemia (CLL) after relatively mild conditioning regimens. "Allogeneic stem cell transplantation (SCT) using...

CD34 cell dose has significant impact on outcome of related, unrelated grafts.
July 10, 2003... 2003 JUL 10 - (NewsRx.com & NewsRx.net) -- Stem cell dose has a significant impact on the outcome of related and unrelated transplants. Researchers at the Fred Hutchinson Cancer Research Center in Seattle conducted a study "to investigate...

Low dose improves survival in peripheral blood recipients.
July 10, 2003... 2003 JUL 10 - (NewsRx.com & NewsRx.net) -- Low stem cell dose improves survival in patients who receive peripheral blood transplants. "Allogeneic peripheral blood stem cell transplantation (PBSCT) has emerged as an alternative to bone...

Phenotype of long-term engrafting cells identified.
July 10, 2003... 2003 JUL 10 - (NewsRx.com & NewsRx.net) -- The phenotype of long-term engrafting stem cells from umbilical cord blood has been identified. "There have been controversies about CD34 and CD38 expression by human cord blood (CB) stem cells,"...

Argatroban used in bypass surgery can avoid heparin-induced thrombocytopenia.
July 10, 2003... 2003 JUL 10 - (NewsRx.com & NewsRx.net) -- In patients with a risk for heparin-induced thrombocytopenia, argatroban can be used instead for operations such as cardiopulmonary bypass. According to a study from the United States, "Whereas...

The BAFF receptor has a unique structure that holds BAFF in the BAFF cage.
July 10, 2003... 2003 JUL 10 - (NewsRx.com & NewsRx.net) -- The BAFF receptor has a unique structure that holds BAFF in the BAFF cage. According to recent research from South Korea, "B-cell activating factor (BAFF) is a key regulator of B-lymphocyte...

IgH clonality can be determined by PCR from paraffinized bone marrow.
July 10, 2003... 2003 JUL 10 - (NewsRx.com & NewsRx.net) -- PCR can be used to check the clonality of IgH to confirm B cell lymphoma involvement in paraffinized bone marrow biopsy. "We investigated whether the determination of clonality by polymerase chain...