Blood Weekly articles from January 2009

Blood Weekly archives from January 2009

Study of placenta unexpectedly leads to cancer gene.
January 1, 2009... University of Rochester Medical Center scientists discovered a gene mutation that impairs the placenta and also is influential in cancer development, according to a study published online December 16, 2008, in the journal PLoS (Public Library...

Allergan, Inc. Announces Nationwide Availability of ACZONE[R] Gel 5%.
January 1, 2009... Allergan Inc. (NYSE: AGN) announced the nationwide availability of ACZONE[R] (dapsone) Gel 5%, a new, first-in-class topical treatment for inflammatory acne.Representing the first new molecule in a decade approved by the FDA for the topical...

Scientists at Khon Kaen University detail research in alpha-thalassemia.
January 1, 2009... "Context.-Thalassemia and hemoglobinopathies are major public health problems worldwide. To establish a cost-effective screening tool for newborns in regions where the incidence of these disorders is significant, study of the hemoglobin and...

Research from Waseda University in the area of artificial oxygen published.(Report)
January 1, 2009... "Hemoglobin vesicles (HbVs) are artificial oxygen carriers encapsulating purified and concentrated Hb solution in phospholipid vesicles (liposomes). We examined in-vitro reaction profiles of a formulation of HbV with NO and CO in anaerobic and...

New findings in blood substitutes described from University of Parma.
January 1, 2009... According to a study from Parma, Italy, "Historically, exogenous administration of hemoglobin solutions to implement the oxygen transport capacity for clinical applications suffered from dramatic drawbacks, resulting in the failure of many...

Research from University of Texas yields new findings on fungemia.
January 1, 2009... "We identified three cases of C. tropicalis strains causing breakthrough fungemia in allogeneic stem cell recipients receiving caspofungin prophylaxis and treatment," researchers in the United States report (see also Fungemia). "Three...

Research from Kyushu University in the area of Gaucher disease described.
January 1, 2009... "The activity of lysosomal acid beta-glucocerebrosidase (AGC, EC 3.2.1.45), which hydrolyzes the O-glycosidic linkage between D-glucose and ceramide of glucosylceramide (GlcCer), is a marker for the diagnosis of Gaucher disease because the...

King's Daughters Medical Center Leverages Unique Bedside Interactive Technology to Meet Requirements of Patient Safety Goal 16.
January 1, 2009... In an effort to improve patient safety and standards compliance, GetWellNetwork, Inc., the leading provider of Interactive Patient Care (IPC) solutions, is enabling King's Daughters Medical Center (KDMC) to meet the requirements of The Joint...

Research conducted at M.D. Gershman and co-authors has provided new information about life sciences.
January 1, 2009... According to a study from the United States, "Pharmaceutical compounding, the manipulation of ingredients to create a customized medication, is a widespread practice. In January 2005, the Centers for Disease Control and Prevention was notified...

Research from National University provide new insights into life sciences.
January 1, 2009... "We have shown that benznidazole (BZL), a drug used to treat Chagas disease, markedly reduced the production of pro-inflammatory cytokines and NO-derived metabolites in experimentally Trypanosoma cruzi-infected rats. Treatment with BZL exerted...

Research on myelodysplastic syndrome published by M.A. Sekeres et al.
January 1, 2009... " Myelodysplastic syndromes (MDS) comprise a group of pathologically and cytogenetically distinct bone marrow disorders. Little is known about the characteristics of MDS patients, including their pathological and prognostic classifications,...

Research reports from Carl Gustav Carus University provide new insights into myelodysplastic syndrome.
January 1, 2009... "The prognosis of patients with de novo myelodysplastic syndrome (MDS) who are red blood cell transfusion-dependent (TD) and receive supportive care is inferior to that of patients who do not require transfusions. Whether TD also affects...

Research reports from N. Douetguilbert and co-authors provide new insights into myelodysplastic syndrome.
January 1, 2009... "Isochromosome of the long arm of chromosome 20 with loss of interstitial material [ider(20q)] is a variant of deletion of chromosome 20q and a rare abnormality in myelodysplastic syndrome (MDS)," researchers in Brest, France report (see also...

Study results from Charite University provide new insights into necrosis.
January 1, 2009... According to recent research from Berlin, Germany, "Context.-Tumor necrosis factor alpha, interleukin 6, and interleukin 8 serum/plasma levels are frequently used for the monitoring of patients with systemic immune activation/sepsis. This...

Report summarizes parotidectomy study findings from Johns Hopkins University.
January 1, 2009... According to recent research published in the journal Laryngoscope, "Free abdominal fat transfer (FAT) grafts have been used after superficial parotidectomy to restore facial contour. We reviewed our experience with the use of FAT...

Scientists at University of Leuven describe research in purpura.
January 1, 2009... According to a study from Heverlee, Belgium, "Phytochemical analysis of the leaves of Boldoa purpurascens Cav. led to isolation of four flavone glycosides, three of which are new compounds. Their structures have been determined by mass...

Data on sepsis discussed by O. Plan and colleagues.
January 1, 2009... According to a study from Montpellier, France, "Intermittent infusion of vancomycin is widely used to treat late-onset sepsis in neonates. On the other hand, the continuous infusion of vancomycin could improve bactericidal efficacy since its...

Reports on sepsis findings from Washington University provide new insights.
January 1, 2009... In this recently published article, scientists in the United States conducted a study "To examine the relationship between treatment-related variables for Candida bloodstream infection and hospital mortality. Retrospective cohort analysis."...

Reports summarize sepsis research from Johann Wolfgang Goethe University.
January 1, 2009... According to recent research published in the journal Critical Care Medicine, "In early stages of septic shock, impaired myocardial function plays an important prognostic role. In this context, B-type natriuretic peptide (BNP) has been shown to...

Researchers at University of Sherbrooke publish new data on sepsis.
January 1, 2009... According to recent research published in the journal Critical Care Medicine, "Sepsis-induced organ dysfunctions remain prevalent and account for >50% of intensive care unit admissions for acute renal failure with a mortality rate nearing 75%....

New findings reported from University of Pittsburgh describe advances in sickle cell anemia.(Clinical report)
January 1, 2009... According to recent research from the United States, "Reduced-intensity conditioning (RIC) regimens have the potential to decrease toxicities related to hematopoietic stem cell transplantation (HCT) in patients with sickle cell disease (SCD)...

Studies from Thomas Jefferson University yield new data on transfusion medicine.(Report)
January 1, 2009... "Acute lung injury (ALI) is a well known complication following the transfusion of blood products and is commonly referred to as transfusion-related acute lung injury (TRALI). The objectives of this review are to summarize current knowledge of...

Studies from Comenius University in the area of whipple disease published.
January 1, 2009... According to recent research from Bratislava, Slovakia, "Whipple's disease is a chronic inflammatory systemic disorder in which all organs can be invaded by the rod-shaped bacterium Tropheryma whipplei. It is a rare disease and frequently...

Scientists at University of Washington, Department of Chemistry publish new data on apoptosis cell biology.
January 1, 2009... Data detailed in 'Differential responses of FLIPLong and FLIPShort-overexpressing human myeloid leukemia cells to TNF-alpha and TRAIL-initiated apoptotic signals' have been presented. "Clonal marrow cells from patients with early...

Reports outline atrial septal defects genetics study findings from Hacettepe University.
January 1, 2009... Researchers detail in 'Familial pulmonary arterial hypertension, leucopenia, and atrial septal defect: a probable new familial syndrome with multisystem involvement,' new data in atrial septal defects. "We present two siblings with identical...

Research reports on chemotherapy from M. Pless and colleagues provide new insights.
January 1, 2009... Scientists discuss in 'Induction chemotherapy followed by parenchyma-sparing surgery in medically inoperable NSCLC-results of a feasibility study' new findings in chemotherapy. "Feasibility trial to test the toxicity and outcome of three cycles...

New Gaucher disease study results from National Human Genome Research Institute described.
January 1, 2009... Current study results from the report, 'Optimization and validation of two miniaturized glucocerebrosidase enzyme assays for high throughput screening,' have been published. "Glucocerebrosidase (GC) catalyzes the hydrolysis of...

Studies from Fudan University, Department of Haematology have provided new information about myelodysplastic syndrome prognosis.(Report)
January 1, 2009... New investigation results, 'Prognostic analysis of refractory anaemia in adult myelodysplastic syndromes,' are detailed in a study published in Chinese Medical Journal. According to recent research from Shanghai, People's Republic of China,...

Scientists at California State University release new data on purpura.
January 1, 2009... Scientists discuss in 'Exogenous hyalin and sea urchin gastrulation. Part III: biological activity of hyalin isolated from Lytechinus pictus embryos' new findings in purpura. According to recent research from the United States, "Hyalin is a...

Investigators at Brown University target sepsis.(Report)
January 1, 2009... Research findings, 'Sepsis strategies in development,' are discussed in a new report. "Severe sepsis, defined as inflammation and organ failure due to infection, continues to result in a mortality of approximately 30% despite advances in...

Researchers at University of British Columbia, Department of Pediatrics release new data on sepsis in children.
January 1, 2009... Investigators publish new data in the report 'Sepsis and septic shock. A global perspective and initiative.' "Sepsis and septic shock are major contributors to mortality in children worldwide. While many factors may contribute to poor outcomes,...

Data on sickle cell anemia in adolescents published by M.M. Al-Qurashi and colleagues.
January 1, 2009... A new study, 'The prevalence of sickle cell disease in Saudi children and adolescents. A community-based survey,' is now available. According to a study from Riyadh, Saudi Arabia, "To determine the prevalence and regional distribution of sickle...

Data on adverse drug reactions reported by researchers at University of Louisville.
January 1, 2009... "Particulate embolization remains a serious complication of cardiac surgery. Adverse events associated with particulate embolization affect patient morbidity and long-term survival, and increase the length of hospital stay and the cost of...

New findings from D.R. Beers and co-authors describe advances in amyotrophic lateral sclerosis.
January 1, 2009... According to recent research published in the journal Proceedings of the National Academy of Sciences of the United States of America, "Neuroinflammation, marked by gliosis and infiltrating T cells, is a prominent pathological feature in...

Research from Virginia Commonwealth University in the area of anatomy described.(Report)
January 1, 2009... "Differences in nasal anatomy among human subjects may cause significant differences in respiratory airflow patterns and subsequent dosimetry of inhaled gases and particles in the respiratory tract. This study used computational fluid dynamics...

Data on aneurysm described by researchers at University of Tokyo, Medical Department.
January 1, 2009... According to a study from Hongo, Japan, "Segmental arterial mediolysis (SAM) is a rare condition characterized by splanchnic arterial catastrophe caused by mediolysis. We report a 59-year-old man with a ruptured splenic arterial aneurysm who...

Findings from University of Toronto provide new insights into aneurysm.(Clinical report)
January 1, 2009... According to recent research from Toronto, Canada, "The objective is to report the feasibility and technique of treating popliteal artery aneurysms (PAA) with a stent made of nitinol rings externally supported by thin polyester (Anaconda...

New findings from E.D. Dillavou and co-researchers in the area of aneurysm described.
January 1, 2009... According to recent research published in the Journal of Vascular Surgery, "Open and endovascular thoracic aneurysm repairs are associated with significant complications including paraplegia, stroke, vascular insufficiency, and death....

Reports by G. Cantore and co-researchers describe recent advances in aneurysm.
January 1, 2009... According to a study from Rome, Italy, "Despite new endovascular techniques and technological advances in microsurgery, the treatment of giant intracranial aneurysms is still a daunting neurosurgical task. Many of these aneurysms have a large,...

Reports outline aneurysm research from Seoul National University.(Report)
January 1, 2009... "The aim of this study was to evaluate the acute and follow-up outcomes of cerebral aneurysms that perforated during endovascular treatment. Nine hundred ten patients harboring 1056 intracranial aneurysms received 1164 endovascular treatments...

Reports outline aneurysm research from University of Leuven.
January 1, 2009... In this recent study, researchers in Louvain, Belgium conducted a study "To assess the incidence and clinical significance of thrombotic, nonocclusive mural deposits in abdominal aortic stent-grafts incidentally found on follow-up computed...

Research conducted at University of Wisconsin has updated our knowledge about aneurysm.
January 1, 2009... "We previously demonstrated an 80% reduction in paraplegia risk using hypothermia, naloxone, steroids, spinal fluid drainage, intercostal ligation, and optimizing hemodynamic parameters. This report demonstrates that intercostal...

Studies conducted at C. Irwin et al on aneurysm recently published.
January 1, 2009... According to recent research published in the Journal of Vascular Surgery, "Although recognized with increasing frequency, the pathogenesis of venous aneurysms (VA) remains poorly understood. We evaluated 8 patients with 10 VA for the presence,...

Studies from J.P. Lejeune and colleagues provide new data on aneurysm.
January 1, 2009... "Neurosurgical management of residual aneurysms (RA) after coiling remains a challenging issue. We present a consecutive series of 21 patients who underwent microsurgical treatment of a previously coiled aneurysm," scientists writing in the...

Studies from V.L. Rayz and colleagues yield new information about aneurysm.(Report)
January 1, 2009... According to recent research from the United States, "The deposition of intralumenal thrombus in intracranial aneurysms adds a risk of thrombo-embolism over and above that posed by mass effect and rupture. In addition to biochemical factors,...

Reports outline angiography research from University of Frankfurt.
January 1, 2009... In this recently published article, scientists in Frankfurt, Germany conducted a study "To evaluate the feasibility of three-dimensional OD) reconstructed contrast-enhanced (CE) magnetic resonance (MR) angiography in mapping the pelvic...

Data on angiology described by Y. Bejot et al.(Clinical report)
January 1, 2009... "There is little reliable population based information about the distribution of risk factors among the various ischaemic stroke subtypes, even though determining risk factor profiles is of major importance to develop targeted preventive...

Data on angiology detailed by researchers at University of Duisburg-Essen.
January 1, 2009... "Risk stratification can contribute to individualised optimal secondary prevention in patients with cerebrovascular disease. To prospectively investigate the prediction of the Essen Stroke Risk Score (ESRS) and a pathological Ankle Brachial...

Data on angiology reported by researchers at University of Bern.
January 1, 2009... According to a study from Bern, Switzerland, "In vitro testing of vertebroplasty techniques including pulsed jet-lavage for fat and marrow removal in human cadaveric lumbar and thoracic vertebrae. To develop jet-lavage techniques for...

New angiology study findings have been reported from Technion.
January 1, 2009... According to recent research from Haifa, Israel, "Acute pulmonary thromboembolism (PE) is a common cause of death in hospital patients. Quick and accurate diagnosis significantly decreases mortality." "Many medical facilities still have...

Research on angiology reported by scientists at University of Hong Kong.
January 1, 2009... According to recent research from Hong Kong, People's Republic of China, "To investigate the effect of oral isoflavone supplement on vascular endothelial function in patients with established cardiovascular disease. A randomized,...

Researchers from Georgetown University detail findings in angiology.
January 1, 2009... "Management of highly vascular carotid body tumors can involve pre-operative percutaneous embolization before definitive surgical resection," scientists in the United States report (see also Angiology). "This step reduces tumor size,...

Researchers from University of Zurich report on findings in angiology.
January 1, 2009... According to recent research from Zurich, Switzerland, "Peripheral arterial disease (PAD) is associated with systemic impaired flow-mediated dilation (FMD) and increased risk for cardiovascular events. Decreased FMD may be caused by a decrease...

Scientists at University of Alabama discuss research in angiology.(Report)
January 1, 2009... "The influence of wall motion on the hemodynamic characteristics of the human femoral bifurcation and its effects on the development of peripheral artery disease has not been previously investigated. This study aimed in investigating the...

New findings from Uppsala University, Biomed Center describe advances in antibiotics.
January 1, 2009... "Small-colony variants (SCVs) of Staphylococcus aureus are associated with persistent infections and may be selectively enriched during antibiotic therapy. Three pairs of clonally related S. aureus isolates were recovered from patients...

Studies from Loyola University Chicago provide new data on antithrombins.(Report)
January 1, 2009... According to recent research from the United States, "Argatroban is an antithrombin (AT) drug approved by the U.S. Food and Drug administration for the anticoagulation of patients with heparin-induced thrombocytopenia (HIT) and for patients at...

Research reports from University of Michigan provide new insights into aortic aneurysms.
January 1, 2009... In this recent report, researchers in the United States conducted a study "To evaluate our initial experience with hypogastric artery, occlusion using a nitinol vascular plug during endovascular aortic aneurysm repair (EVAR). We reviewed the...

New findings reported from C. Musto and co-authors describe advances in aortic coarctation.(Report)
January 1, 2009... "Endovascular management of aortic coarctation ( CoA) is safe but few data are available concerning the long-term cure of hypertension. Aim of this study was to evaluate immediate and long-term clinical and haemodynamic outcome in a consecutive...

Researchers' work from National Technical University focuses on aplastic anemia.
January 1, 2009... According to recent research published in the journal Thyroid, "Antithyroid drugs have been used for more than 50 years for the management of hyperthyroidism. Most patients tolerate treatment well but some may develop life threatening side...

Data on apoptosis detailed by K.L. Khanduja and co-authors.
January 1, 2009... According to a study from Chandigarh, India, "We investigated the possible mechanisms of All-trans retinoic acid (ATRA)-promoted apoptosis induced by alpha-tocopherol succinate (alpha-TS) in freshly isolated leukemic cells obtained from chronic...

Research from University of Pennsylvania broadens understanding of arteriovenous malformation.
January 1, 2009... In this recent article published in the Journal of Vascular and Interventional Radiology, scientists in the United States conducted a study "To compare digital subtraction pulmonary arteriography (PA) with 16-detector row computed tomography...

Research results from University of Barcelona update knowledge of artificial organs.(Report)
January 1, 2009... "The aim of this study was to determine the optimal positive end-expiratory pressure (PEEP) required during extracorporeal lung membrane support (interventional lung assist [iLA]; Novalung GmbH, Hechingen, Germany). Twenty healthy pigs were...

Researchers from University of Ottawa report recent findings in artificial organs.
January 1, 2009... According to a study from Ottawa, Canada, "This article describes two ongoing numerical studies of fluid-structure interaction in the cardiovascular system: an idealized pulsatile ventricular assist device (VAD), consisting of two fluid...

New atherosclerosis study findings have been published by scientists at University of Cambridge.(Report)
January 1, 2009... "Cell biological studies demonstrate remarkable similarities between mineralization processes in bone and vasculature, but knowledge of the components acting to initiate mineralization in atherosclerosis is limited. The molecular level...

Research reports from University of Leipzig provide new insights into atherosclerosis.
January 1, 2009... "The nuclear liver X receptor-alpha (LXR-alpha) has been implicated in the regulation of intracellular cholesterol homeostasis, inflammatory response, and atherosclerosis susceptibility. The aim of the present study was to test whether...

Researchers from Blood Center report recent findings in atherosclerosis.
January 1, 2009... According to recent research from the United States, "Atherosclerosis is a vascular disease that involves lesion formation at sites of disturbed flow under the influence of genetic and environmental factors. Endothelial expression of adhesion...

Data from S.J. Connolly and colleagues advance knowledge in atrial fibrillation.
January 1, 2009... According to recent research from Hamilton, Canada, "Oral anticoagulation (OAC) therapy is effective in atrial fibrillation but requires vigilance to maintain the international normalized ratio in the therapeutic range. This report examines how...

Data on atrial fibrillation reported by Z.M. Anastas and co-researchers.(Report)
January 1, 2009... "Limited research is available on the accuracy of automatic blood pressure (BP) measurement devices in patients with irregular rhythms. The purpose of this study was to examine the agreement between different methods for noninvasive BP...

Research on atrial fibrillation published by M. Lemay et al.(Report)
January 1, 2009... According to recent research from Lausanne, Switzerland, "Phase-rectified signal averaging (PRSA) is a technique recently introduced to enhance quasi-periodic signal components. An important parameter that can be extracted from surface ECG is...

Data on B-cell lymphoma described by researchers at University of Pittsburgh.
January 1, 2009... According to recent research from the United States, "Lymphoplasmacytic lymphoma (LPL) is a small B-cell lymphoma with plasmacytic differentiation that does not fulfill the criteria for any other small B-cell lymphoma. Cytogenetic...

Research from H. Nagai and co-authors yields new data on B-cell lymphoma.(Report)
January 1, 2009... "Many controlled clinical trials have proven that rituximab improves the clinical outcome of patients with mature B cell lymphoma. This study was conducted to assess the contribution of rituximab in the actual clinical practice," researchers in...

Study results from University of Massachusetts, Medical Department in the area of B-cell lymphoma published.
January 1, 2009... According to a study from the United States, "The Inhibitor of Growth (ING) gene family encodes structurally related proteins that alter chromatin to regulate gene expression and cell growth. The initial member, ING1, has also been proposed to...

New behavior study findings have been published by scientists at Wake Forest University, Medical Department.(Report)
January 1, 2009... "An understanding of the mechanical deformation behavior of the liver under high strain rate loading conditions could aid in the development of vehicle safety measures to reduce the occurrence of blunt liver injury. The purpose of this study...

Study results from B.M. Schaefer and colleagues in the area of bicuspid aortic valves published.
January 1, 2009... In this recently published article, scientists in the United States conducted a study "To establish a classification of bicuspid aortic valve (BAV) that includes both leaflet morphology and aortic shape. Two academic medical centres of the...

Reports from W.S. Gong et al highlight recent research in bioengineering.
January 1, 2009... "We investigated the vestibulo-ocular responses (VORs) evoked by bilateral electrical stimulation of the nerves innervating horizontal semicircular canals in squirrel monkeys and compared these responses to those evoked by unilateral...

Studies from Hacettepe University have provided new data on bioengineering.(Report)
January 1, 2009... "Determination of electrically active regions in the human body by observing generated bioelectric and/or biomagnetic signals is known as source reconstruction. In the reconstruction process, it is assumed that the volume conductor consists of...

New biomedicine data have been reported by researchers at St. John Fisher College.
January 1, 2009... "Though ubiquitous across the medical social sciences literature, the term ''biomedicine'' as an analytical concept remains remarkably slippery. It is argued here that this imprecision is due in part to the fact that biomedicine is comprised...

Researchers at University of Manchester target biomedicine.
January 1, 2009... According to a study from Manchester, the United Kingdom, "FACTA is a text search engine for MEDLINE abstracts, which is designed particularly to help users browse biomedical concepts (e.g. genes/proteins, diseases, enzymes and chemical...

Researchers from University of Canterbury provide details of new studies and findings in the area of biomedicine.(Report)
January 1, 2009... "Results from the application of three nonlinear stiffness reconstruction algorithms to two simple cylindrical geometries are presented in this paper. Finite-element simulated harmonic motion data with added noise were initially used to...

Baylor College of Medicine, College of Medicine publishes research in blood and marrow transplantation.
January 1, 2009... "Graft failure is a significant cause of morbidity and mortality after hematopoietic stem cell transplantation (HSCT). We used a nonmyeloablative conditioning regimen consisting of the lympho-depleting humanized CD52-antibody Campath-IH and...

New blood pressure findings from Medical University of Graz published.(Clinical report)
January 1, 2009... In this recent report, researchers in Graz, Austria conducted a study "To test the hypothesis that enhanced postexercise vasodilatation is related to sympathetic drive to resistance vessels and to fast marathon performance. Prospective field...

Research data from University of Limpopo update understanding of blood pressure.
January 1, 2009... "Most studies on the anti hypertensive effects of bioflavonoids have reported short-term effects (within 7 weeks) at high concentrations (40-100 mg kg(-1) day(-1)). The present study by contrast has investigated long-term effects of low...

Research from M. Ashworth and co-authors in the area of blood pressure published.
January 1, 2009... According to recent research published in the British Medical Journal, " To determine levels of blood pressure monitoring and control in primary care and to determine the effect of social deprivation on these levels. Retrospective longitudinal...

Studies from University of Sydney reveal new findings on blood pressure.
January 1, 2009... "Large-scale observational studies show that lower blood pressure is associated with lower cardiovascular risk in both men and women although some studies have suggested that different outcomes between the sexes may reflect different responses...