Blood Weekly articles from February 2009

Blood Weekly archives from February 2009

New tools can better predict successful kidney transplant outcomes.
February 5, 2009... Kidney transplants are the best available therapy for end stage renal disease. Because of the shortage of deceased organ donors, living donor transplantation is rapidly growing and has the advantage of improved outcomes over deceased donor...

Measurement of kidney function in children with kidney disease improved.(Report)
February 5, 2009... A formula used to measure kidney function in children with chronic kidney disease has been revised to make it more precise, according to a study published online January 21 in the Journal of the American Society of Nephrology. This study is...

Researchers detail how aging undermines bone healing.
February 5, 2009... Researchers have unraveled crucial details of how aging causes broken bones to heal slowly, or not at all, according to study results published in the Journal of Bone and Mineral Research. The research team also successfully conducted...

Data on acute promyelocytic leukemia detailed by C. Santamaria and co-authors.
February 5, 2009... According to recent research from Salamanca, Spain, " The gene for preferentially expressed antigen of melanoma (PRAME) has been shown to be over-expressed in acute promyelocytic leukemia, but its actual incidence and clinical impact are still...

Recent findings in alpha-thalassemia described by researchers from Chiang Mai University.(Report)
February 5, 2009... According to recent research from Chiang Mai, Thailand, "The objective of this study was to compare red blood cell indices among normal, alpha-thalassemia-1 trait, and hemoglobin (Hb) Bart's fetuses at mid-pregnancy. A total of 87 pregnancies...

Research from N.J. Weinreb and co-authors provides new data about Gaucher disease.
February 5, 2009... According to recent research from the United States, "We estimated life expectancy at birth for Gaucher disease type 1 (GD1) patients by comparing survival data from GD1 patients enrolled in ICGG Gaucher Registry to the U.S. population using...

New graft-versus-host disease study findings have been published by scientists at Harvard University.
February 5, 2009... In this recently published study, investigators in the United States conducted a study "To determine the natural history of and guidelines for the surgical management of severe acute gastrointestinal (GI) graft-vs-host disease (GVHD) after...

Cleveland Clinic publishes research in hematologic disease.
February 5, 2009... "Fludarabine and 200 cGy TBI are commonly used for reduced-intensity conditioning preceding allogeneic hematopoietic SCT (HSCT). However, graft rejection and disease relapse are significant causes of treatment failure with this regimen,"...

New research on hemophilia a from A. Goodeve and co-authors summarized.
February 5, 2009... According to a study from Sheffield, the United Kingdom, "Genetic testing in hemophilia A. continues to diversify. This article describes recent advances in several aspects of genetic analysis and Its interpretation and reporting." "The...

Reports from Catholic University highlight recent research in hypertension.
February 5, 2009... "The objective of this article is to study the cumulative incidence of intra-abdominal hypertension (IAH) in septic shock (SS) patients during the first 72 hours of intensive care unit (ICU) admission and to determine if the presence and...

Investigators at University of Nottingham have published new data on insulin resistance.
February 5, 2009... According to recent research from Nottingham, the United Kingdom, "Sepsis causes muscle atrophy and insulin resistance, but the underlying mechanisms are unclear. Therefore, the present study examined the effects of lipopolysaccharide...

Reports from N.A. Khan and co-researchers add new data to research in life sciences.(Clinical report)
February 5, 2009... "It is unclear whether race/ethnicity influences survival for acute critical illnesses. We compared hospital mortality among patients of Asian (originating from Asia or Southeast Asia), Native Indian, and European descent admitted to the ICU,"...

Reports on life sciences findings from Virginia Commonwealth University provide new insights.
February 5, 2009... According to recent research from the United States, "Murine studies using anti-T-cell antibodies for conditioning in allogeneic SCT demonstrate engraftment with low rates of GVHD. On the basis of this preclinical model, we conditioned 30...

Research from Tulane University, Medical Department has provided new information about life sciences.(Report)
February 5, 2009... According to recent research from the United States, "Although splenic angioembolization (SAE) has been introduced and adopted in many trauma centers, the appropriate selection for and utility of SAE in trauma patients remains under debate....

Researchers' work from Ghent University focuses on life sciences.(Report)
February 5, 2009... "Chromosomal translocations involving the EVI1 locus are a recurrent finding in myeloid leukemia and are associated with poor prognosis. In this study, we performed a detailed molecular characterization of the recurrent translocation...

Scientists at Korea University target magnetic resonance.
February 5, 2009... According to a study from South Korea, "Revision Bankart operations frequently show capsulolabral buttress loss and recurrent soft tissue Bankart lesion. Capsulolabral augmentation is designed to increase glenohumeral stability by 2 separate...

Studies from A.V. Kalade and co-authors have provided new information about mediastinal lymphadenopathy.(Report)
February 5, 2009... "The aim of this study was to assess the incremental value of endoscopic ultrasound (EUS)-guided fine-needle aspiration (FNA) to positron emission tomography ( PET) in the diagnosis of unexplained mediastinal lymphadenopathy and staging of...

Studies from Cukurova University, Medical Department add new findings in the area of mucormycosis.
February 5, 2009... According to a study from Adana, Turkey, "Among patients with haematologic disorders, mucormycosis most commonly occurs in those with acute leukaemia or lymphoma who have developed neutropenia due to malignancy or to chemotherapy, and in...

Research reports from N. Sugimori and co-authors provide new insights into myelodysplastic syndrome.(Clinical report)
February 5, 2009... "Some patients with myelodysplastic syndrome (MDS) show a marked increase in the percentage of immature platelet fraction (IPF%) despite the absence of severe thrombocytopenia. To determine the significance of such an unbalanced increase in the...

Researchers from Royal Adelaide Hospital publish new studies and findings in the area of myelodysplastic syndrome.
February 5, 2009... Researchers in Adelaide, Australia conducted a study "To study disease characteristics of adult patients with myelodysplastic syndromes (MDS) in South Australia and to analyse their outcome and survival. One hundred and eight adult patients...

New findings from T. Savage and co-authors describe advances in necrosis.
February 5, 2009... According to a study from Galway, Ireland, "Tumor necrosis factor receptor-associated periodic syndrome (TRAPS) is one of a number of well described hereditary periodic febrile syndromes. We report a case in an infant, with a strong family...

Data on neutropenia detailed by researchers at Monash University.
February 5, 2009... "A major randomized clinical trial, evaluating voriconazole versus liposomal amphotericin B (LAMB) as empirical therapy in febrile neutropenia, recommended voriconazole as a suitable alternative to LAMB. The current study sought to investigate...

Reports from University of Dublin add new data to research in neutropenia.
February 5, 2009... "X-linked neutropenia (XLN, OMIM #300299) is a rare form of severe congenital neutropenia. It was originally described in a three-generation family with five affected members that had an L270P mutation in the GTP-ase binding domain (GBD) of the...

Findings from Novartis in pharmacokinetics reported.
February 5, 2009... "Deferasirox (Exjade, ICL670, CGP72670) is an iron-chelating drug for p.o. treatment of transfusional iron overload in patients with beta-thalassemia or sickle cell disease. The pharmacokinetics and disposition of deferasirox were investigated...

ScienceFirst Staff Expansion.
February 5, 2009... ScienceFirst is pleased to announce that two new associates have joined the Cedar Knolls office (see also ScienceFirst). Valery Sudakin, PhD, has been named science manager. Before joining ScienceFirst, Dr. Sudakin was an investigator at...

Investigators at University of Medicine and Dentistry of New Jersey zero in on sepsis.
February 5, 2009... "Severe sepsis and acute lung injury are challenging diagnoses as they relate to designing and reporting of clinical trials. The limited success in bringing forward new therapies in these areas is likely proof of that Premise," investigators in...

New sepsis findings from Toyama University published.
February 5, 2009... According to recent research from Toyama, Japan, "The use of glucocorticoids for treatment of sepsis has waxed and waned during the past several decades, and recent randomized controlled trials have evoked a reassessment of this therapy. Most...

New sepsis study findings reported from University of Pennsylvania, Medical Department.
February 5, 2009... " Sepsis - terminology and basic facts The pathways of complement activation The role of the complement system in the pathogenesis of sepsis Aetiology-dependent mechanisms of complement activation in sepsis Sepsis-associated coagulopathy and...

Recent findings from University of Cincinnati highlight research in sepsis.
February 5, 2009... "The expected benefit of treating severe sepsis with drotrecogin a (activated) for an individual patient may depend upon several clinical factors including disease severity. Our objective was to create a decision support tool incorporating...

Reports on sepsis findings from National University provide new insights.(Clinical report)
February 5, 2009... "This study is to investigate the clinical utility of detection of peripheral blood triggering receptor expressed on myeloid cells (TREM)-1 mRNA as an early indicator of sepsis among critically ill patients and to compare the results of TREM-1...

Research findings from University of East London update understanding of sepsis.
February 5, 2009... "Studies have shown the efficacy of intra-partum antibiotics in preventing early-onset group B streptococcal sepsis. This approach results in a high intra-partum antibiotic use," scientists writing in the Journal of Antimicrobial Chemotherapy...

Research findings from University of Heidelberg update understanding of sepsis.
February 5, 2009... "It was hypothesized that the inflammatory response of patients with severe sepsis may result in changes of plasma levels of oxidized low-density lipoproteins (ox-LDLs) and that drotrecogin (activated) (DAA) (Xigris, Eli Lilly and Company...

Research from Cooper University provide new insights into sepsis.
February 5, 2009... "No studies have specifically evaluated the incidence or clinical characteristics of atrial fibrillation (AF) in a mixed medical-surgical population of patients with sepsis. We undertook to determine the incidence and clinical Course of...

Scientists at Free University release new data on sepsis.(Report)
February 5, 2009... According to a study from Brussels, Belgium, "The aim of this study is to evaluate the feasibility of applying sepsis bundles in the intensive care unit (ICU) and their effect on outcomes. In this prospective, observational study in a 31-bed...

Scientists at National Chung-Hsing University release new data on sepsis.
February 5, 2009... "Sepsis is a complicated syndrome in which proinflammatory and anti-inflammatory cytokines are expressed simultaneously. However, it remains unclear for the expression of interleukin (IL)-4 and IL-4 delta 2 in patients with severe sepsis,"...

Studies from Free University in the area of sepsis published.(Report)
February 5, 2009... According to recent research from Brussels, Belgium, "The aim of the study was to investigate predictors of post-intensive care unit (ICU) in-hospital mortality with special emphasis oil the impact of sepsis and organ system failure. This study...

Studies from W.L. Chang et al provide new data on sickle cell anemia.
February 5, 2009... "A 27-year-old female with sickle cell disease (HbSS) was admitted presenting with severe bone pain and fever. She refused blood transfusions throughout her hospital stay for religious reasons," scientists in the United States report (see also...

Studies from Keio University, Medical Department further understanding of stem cell research.(Report)
February 5, 2009... According to a study from Tokyo, Japan, "High-dose cytarabine is one of the major components of the conditioning regimen for hematopoietic stem cell transplantation (HSCT), and frequently causes severe oral mucositis. We have recently...

New transfusion medicine study findings reported from University of California.(Report)
February 5, 2009... "The objective of this study was to analyze the outcomes associated with uncross-matched blood transfusion during trauma resuscitation. Our hypothesis was that uncross-matched blood transfusion is a predictor of the need for massive transfusion...

Research from Osaka Medical Center in the area of acute leukemia therapy published.
February 5, 2009... A report, 'Fulminant septicemia of Bacillus cereus resistant to carbapenem in a patient with biphenotypic acute leukemia,' is newly published data in Journal of Infection and Chemotherapy. According to recent research published in the Journal...

Research from A.J. Brink and co-authors yields new data on clinical trial research.
February 5, 2009... Data detailed in 'Recommendations to achieve rapid therapeutic teicoplanin plasma concentrations in adult hospitalised patients treated for sepsis' have been presented. "The optimum teicoplanin loading dose and duration of therapy required for...

Study data from Duke University, Department of Medicine update knowledge of sepsis prevention.(Report)
February 5, 2009... A report, 'APOE genotype affects outcome in a murine model of sepsis: implications for a new treatment strategy,' is newly published data in Anaesthesia and Intensive Care. "In this study, we assessed whether apolipoprotein E (APOE)...

New findings from School of Medicine in the area of sepsis therapy published.(Report)
February 5, 2009... Research findings, 'The mitochondria-targeted antioxidant MitoQ protects against organ damage in a lipopolysaccharide-peptidoglycan model of sepsis,' are discussed in a new report. "Sepsis is characterised by a systemic dysregulated...

Studies in the area of sepsis therapy reported from J.L. Del Pozo and co-researchers.(Clinical report)
February 5, 2009... Data detailed in 'Effectiveness of the antibiotic lock therapy for the treatment of port-related enterococci, Gram-negative, or Gram-positive bacilli bloodstream infections' have been presented. "The purpose of this study is to evaluate the...

Recent findings from W.W. Piette and co-authors highlight research in acne vulgaris.(Clinical report)
February 5, 2009... In this recent article published in the journal Archives of Dermatology, scientists in the United States conducted a study "To evaluate the risk of hemolysis in subjects with glucose-6-phosphate dehydrogenase (G6PD) deficiency who were treated...

Research reports on acute myeloid leukemia from M.E.D. Chamuleau and colleagues provide new insights.
February 5, 2009... "Indoleamine 2,3-dioxygenase degrades the amino acid tryptophan which is essential for T cells. Tryptophan depletion causes T-cell cycle arrest and solid tumors that express high levels of indoleamine 2,3-dioxygenase can create immune...

Study findings on acute myeloid leukemia are outlined in reports from University of Udine.
February 5, 2009... According to recent research from Udine, Italy, "WT1 overexpression is described in several oncological diseases including acute myeloid leukemia (AML). Quantification of WT1 in bone marrow samples may be useful as a marker of minimal residual...

New research on adenovirus from Temple University summarized.
February 5, 2009... According to recent research from the United States, "Allograft inflammatory factor-1 (AIF-1) is a calcium-binding, scaffold-signalling protein expressed in vascular smooth muscle cells (VSMCs) in response to injury. The effects of AIF-1...

Research results from Medical University of Vienna update understanding of alcoholism.
February 5, 2009... According to a study from Vienna, Austria, "Originally, aetiology of liver disease has been incorporated into the computation of the Model of End-stage Liver Disease (MELD) score. Clinical observations prompted us to hypothesize that patients...

Findings from K. Pekkan and co-authors broaden understanding of anatomy.
February 5, 2009... "Flow structures, hemodynamics and the hydrodynamic surgical pathway resistances of the final stage functional single ventricle reconstruction, namely the total cavopulmonary connection (TCPC) anatomy, have been investigated extensively....

Data from Kyoto University advance knowledge in aneurysm.
February 5, 2009... According to recent research from Kyoto, Japan, "Recanalization after coil embolization of cerebral aneurysms remains a limitation of this progressively accepted modality. The Matrix detachable bioabsorbable coil (Boston Scientific...

New aneurysm study results reported from I. Linfante et al.
February 5, 2009... According to a study from the United States, "Nicardipine has been used to treat cerebral vasospasm in patients with aneurysmal subarachnoid hemorrhage. Intra-arterial (IA) infusion of high concentrations of nicardipine decreases procedure...

Research on aneurysm described by scientists at Tohoku University.(Report)
February 5, 2009... According to a study from Sendai, Japan, "In ultrasonic-measurement-integrated (UMI) simulation of blood flows, feedback signals proportional to the difference of velocity vector optimally estimated from Doppler velocities are applied in the...

Nara Medical University reports research in angiology.
February 5, 2009... "Isoflurane has been shown to induce tolerance against ischaemic injury in adult rodents. Although the delayed preconditioning effect of isoflurane has been demonstrated in neonatal rat pups, the acute preconditioning effects of isoflurane...

Scientists at Thomas Jefferson University publish research in angiomyolipoma.
February 5, 2009... According to recent research from the United States, "Introduction/objective: To describe a novel. management approach to patients presenting for living renal donation who have a suspicious renal mass or cyst and review the current literature...

Researchers from Sichuan University report on findings in angiotensins.
February 5, 2009... According to recent research published in the journal Biomedical Chromatography, "The capability of biopartitioning micellar chromatography (BMC), using pure Brij35 solution and mixed micellar system of Brij35-SDS (85:15) as mobile phase, to...

Data on apoptosis described by researchers at East Tennessee State University.
February 5, 2009... According to a study from the United States, "Bifunctional apoptosis regulator (BAR) is an endoplasmic reticulum protein that interacts with both the extrinsic and intrinsic apoptosis pathways. We hypothesize that over-expression of BAR Delta...

Research from University of Colorado in the area of apoptosis published.
February 5, 2009... According to a study from the United States, "Controlled matrix interactions were presented to pancreatic beta-cells in three-dimensional culture within poly (ethylene glycol) hydrogels. Dispersed MIN6 b-cells were encapsulated in gel...

New arthritis study findings recently were published by P.C.P.M. Verschueren and co-researchers.
February 5, 2009... In this recent study, researchers in Louvain, Belgium conducted a study "To characterise the bone morphogenetic protein (BMP) target cells positive for phosphorylated (P)-SMAD1/5, in rheumatoid arthritis (RA) synovium. Synovial biopsies were...

Study findings on arthroplasty are outlined in reports from Mayo Clinic.
February 5, 2009... According to recent research published in the journal Clinical Orthopaedics and Related Research, "Most reports on two-stage reimplantation have focused on the short-term cure rate of infection, but little is known about long-term...

Studies from A. Akl et al provide new data on artificial neural networks.
February 5, 2009... According to recent research from Mansoura, Egypt, "An artificial neural networks (ANNs) model was developed to predict 5-year graft survival of living-donor kidney transplants. Predictions from the validated ANNs were compared with Cox...

Findings in atherosclerosis reported from Vanderbilt University, Medical Department.
February 5, 2009... According to recent research published in the journal Cell Metabolism, "Prostaglandin (PG) E-2, a major product of activated macrophages, has been implicated in atherosclerosis and plaque rupture. The PGE(2) receptors, EP2 and EP4, are...

Data on atopic dermatitis discussed by researchers at Technical University of Dresden.
February 5, 2009... "In this double-blind, within-patient vehicle-controlled study, patients with mild-to-moderate atopic dermatitis (AD) were treated for 3 weeks twice daily with pimecrolimus cream 1% on one forearm and with vehicle cream on the other forearm....

Research reports from T. Forst and co-authors provide new insights into atorvastatin.
February 5, 2009... According to recent research from Mainz, Germany, "We investigated the effect of atorvastatin monotherapy and combined treatment with atorvastatin and pioglitazone on intima-media thickness, vascular function and the cardiovascular risk...

Recent findings from A. Martin and co-authors highlight research in B-cell lymphoma.(Report)
February 5, 2009... According to recent research published in the Haematologica - the Hematology Journal, " The role of re-treatment with rituximab in aggressive B-cell lymphomas still needs to be defined. This study evaluated the influence of prior exposure to...

Reports summarize B-cell lymphoma research from Kuopio University.
February 5, 2009... " There is currently limited experience on the feasibility and efficacy of autologous stem cell transplantation in elderly patients with diffuse large B-cell lymphoma. Design and Methods We analyzed the outcome of 2612 patients with diffuse...

Researchers from University of Connecticut discuss findings in behavior.(Report)
February 5, 2009... According to recent research from the United States, "This study evaluates employees' health and lifestyle changes following health risk appraisal only and health risk appraisal with a consultation (HRAC) based on the constructs of...

Studies from University Hospital describe new findings in lung cancer.
February 5, 2009... "Due to recent advances in imaging, the incidence of patients presenting with bilateral lung lesions is increasing. A single contralateral lung lesion can be an isolated metastasis or a synchronous second primary lung cancer," researchers in...

Data from H.E. Bays et al provide new insights into blood pressure.
February 5, 2009... "Nicotinic acid (niacin) is a well-established treatment for dyslipidaemia - an important cardiovascular disease (CVD) risk factor. However, niacin may also reduce blood pressure (BP), which is another important CVD risk factor," scientists in...

Findings from Harvard University provide new insights into blood pressure.
February 5, 2009... "Research on societal determinants of health suggests the existence of an ''inverse hazard law.'' which we define as: ''The accumulation of health hazards tends to vary inversely with the power and resources of the populations affected.'' Yet,...

Scientists at University of Illinois describe research in blood pressure.(Report)
February 5, 2009... According to a study from the United States, "Heffernan KS, Jae SY, Wilund KR, Woods JA, Fernhall B. Racial differences in central blood pressure and vascular function in young men. Am J Physiol Heart Circ Physiol 295: H2380-H2387, 2008." ...

University of Utah publishes research in blood pressure.
February 5, 2009... According to recent research published in the journal Cell Metabolism, "Thiazolidinediones (TZDs) are PPAR gamma activators that exhibit vasculoprotective properties. To determine the vascular function of PPAR gamma, we analyzed Tie2-Cre/flox...

Investigators at University of Sao Paulo release new data on bone marrow.
February 5, 2009... "Vitamin B-6 has shown to be a potentially effective antioxidant agent, and dietary antioxidants are also frequently valuable inhibitors of clastogenesis and carcinogenesis. The purpose of the present work was to study the clastogenicity of...

Reports from University of California add new data to research in bone research.
February 5, 2009... "The in vivo transplantation assay has become a valuable tool for assessing the osteogenic potential of diverse cell populations. It has required that cells are cotransplanted with a matrix into recipient animals using large incisions and...

Research conducted at McGill University has updated our knowledge about bone research.
February 5, 2009... "An ideal material for maxillofacial vertical bone augmentation procedures should not only be osteo-conductive, biocompatible and mechanically strong, but should also be applied using minimally invasive procedures and remain stable with respect...

Research results from A. Ayhanci and colleagues update understanding of bone research.(Report)
February 5, 2009... According to recent research published in the journal Biological Trace Element Research, "Cyclophosphamide (CP) is widely used for the treatment of neoplastic diseases; however, its toxicity causes dose-limiting side effects. Zinc (Zn) is an...

Research results from R. Gapski and co-authors update knowledge of bone research.
February 5, 2009... According to recent research from Curitiba, Brazil, "This case report documents the histological, histomorphometric, and radiographic effects of a new, radiated-preserved bone allograft for sinus elevation procedures. This unique bone...

Study results from M. Orrego and colleagues in the area of bone research published.(Report)
February 5, 2009... "The purpose of this study was to determine if the use of platelet concentrate (PC) and bone plug (BP) does accelerate the healing process in anterior cruciate ligament (ACL) reconstruction. One hundred and eight patients requiring ACL...

Study results from University of Alberta broaden understanding of bone research.(Report)
February 5, 2009... "The purpose of this study was to investigate the preparation process of bone morphogenetic protein-2 (BMP-2) containing bovine serum albumin (BSA) nanoparticles (NPs), and to assess the bioactivity of BMP-2 encapsulated in such NPs. The NPs...

Research conducted at Musashino University has provided new information about breast cancer.
February 5, 2009... "Although several molecular markers for human breast cancer exist, their versatility is limited. Here we demonstrate, through a differential proteome analysis utilizing the fluorogenic derivatization-liquid chromatography/tandem mass...

Research on breast cancer described by S. Blair and colleagues.
February 5, 2009... "Fatigue is a common complication of adjuvant chemotherapy and compromises the quality of life of breast cancer survivors. We sought to correlate serial hemoglobin (Hb) levels with fatigue in a population of women on adjuvant chemotherapy, none...

Studies from Erasmus University have provided new data on bronchiolitis.
February 5, 2009... According to recent research from Netherlands, "In human lung transplantation, chronic rejection is accompanied by obliterative bronchiolitis (013), a fibrosing inflammatory condition that leads to occlusion of the bronchial lumen and graft...

New findings from Cleveland Clinic in the area of bronchogenic cancer described.
February 5, 2009... According to recent research from the United States, "Lung cancer may Occur in the lung transplant population because many patients are former smokers. Not much is known about risk factors and outcomes in these patients." "We performed a...

Findings from M.S. Hamed et al in c reactive protein reported.
February 5, 2009... According to recent research from the United States, "Dark chocolate (DC) is one of the richest sources of flavonoids. Since DC has been demonstrated to have beneficial effects on the cardiovascular system, our study examined its effect on...