Blood Weekly articles from December 2008

Blood Weekly archives from December 2008

New clue emerges for cellular damage in Huntington's disease.
December 4, 2008... CAMBRIDGE, Mass. (November 17, 2008) u "Huntington's disease presents an ideal vantage point to study neurodegenerative disease, because we know the misfolded protein that's responsible," says Martin Duennwald, formerly a postdoctoral...

Alzheimer's Gene Slows Brain's Ability to Export Toxic Protein.
December 4, 2008... The only known genetic risk factor for Alzheimer's disease slows down the brain's ability to export a toxic protein known as amyloid-beta that is central to the damage the disease causes, scientists have found (see also Alzheimer Disease). ...

Findings from Charite University provide new insights into autoimmune hemolytic anemia.(Report)
December 4, 2008... According to a study from Berlin, Germany, "Autoimmune hemolytic anemia (AIHA) is usually classified as either warm or cold type. During the past few decades, mixed types (Mxs) have also been described in a number of cases (6%-8% of AIHA),...

New findings from J. Galletti and co-authors describe advances in autoimmune hemolytic anemia.(Report)
December 4, 2008... According to recent research from Buenos Aires, Argentina, "The mechanisms underlying the frequent association between chronic lymphocytic leukemia (CLL) and autoimmune hemolytic anemia are currently unclear. The erythrocyte protein band 3 (B3)...

Study findings from N.I. Shapiro et al provide new insights into bacteremia.(Clinical report)
December 4, 2008... According to a study from the United States, "The study objective was to derive and validate a clinical decision rule for obtaining blood cultures in Emergency Department (ED) patients with suspected infection. This was a prospective,...

Studies from University of Nebraska yield new data on hematologic disease.
December 4, 2008... According to recent research from the United States, "A significant need exists for effective and well-tolerated treatments for patients with hematologic malignancies. Bendamustine hydrochloride is a novel cytotoxic agent that possesses...

Study results from Alfred Hospital in the area of influenza published.
December 4, 2008... According to recent research from Melbourne, Australia, "A 24-year old female who had been intubated for respiratory distress was transferred to our intensive care unit, where a subsequent diagnosis of Guillain Barre Syndrome was made. Her only...

Reports summarize lactic acidosis study results from Korea University, Emergency Department.(Report)
December 4, 2008... In this recent article published in the Emergency Medicine Journal, scientists in South Korea conducted a study "To compare the prognostic abilities of lactic acidosis and hyperlactatemia and determine the influence of metabolic acidosis when...

Findings from L.R. Franca and co-researchers advance knowledge in life sciences.(Clinical report)
December 4, 2008... In this recently published study, investigators in Paris, France conducted a study "To estimate the impact of drotrecogin alfa (DA) on intensive care workload in an observational study while illustrating the use of propensity score (PS)...

New life sciences findings from A.W. Bernard and co-researchers published.
December 4, 2008... According to recent research from the United States, "Sickle cell patients commonly present to the emergency department (ED). Identifying those requiring admission and those who can safely be discharged is difficult." "It was hypothesised...

New life sciences findings from M. Veihola and co-authors described.
December 4, 2008... According to a study from Helsinki, Finland, "Given increasing cost pressures, the need to improve the technical efficiency of the production chain used for collected blood in blood banking should be recognised. Data envelopment analysis (DEA)...

Report summarizes life sciences study findings from L. Morey and co-researchers.
December 4, 2008... "In plants, as in mammals, mutations in SNF2-like DNA helicases/ATPases were shown to affect not only chromatin structure but also global methylation patterns, suggesting a potential functional link between chromatin structure and epigenetic...

Studies from A.P. Mank et al have provided new data on life sciences.
December 4, 2008... According to recent research from Netherlands, "Patients with haematological malignancies have periods of neutropenia caused by the disease process and subsequent treatments, during which time they are at an increased risk of developing Life...

Researchers at National Cancer Institute release new data on myelodysplastic syndrome.
December 4, 2008... According to recent research published in the journal Proceedings of the National Academy of Sciences of the United States of America, "The myelodysplastic syndromes (MDS) comprise a group of premalignant hematologic disorders characterized by...

Research from Dokuz Eylul University, Medical Department yields new data on neutropenia.
December 4, 2008... "This prospective study analysed 83 patients (age 45 +/- 17 years) with haematological neoplasms, implanted with 93 tunnelled catheters, who were neutropenic or developed neutropenia during treatment. Catheters were implanted in the right (n =...

Research from R.L. Derr et al has provided new information about neutropenia.
December 4, 2008... In this recent report, researchers in the United States conducted a study "To use bone marrow transplantation (BMT) as a model for testing the association between hyperglycemia and infection. This cohort study included 382 adults (6.5% with...

Research from St. George's University reveals new findings on neutropenia.(Clinical report)
December 4, 2008... "Goals of work Neutropenia is a life-threatening, dose-limiting toxicity of many chemotherapy regimens. The goals of this study were to assess the incidence and risk of chemotherapy-induced neutropenia, febrile neutropenia (FN) and dose...

Investigators at Mayo Clinic release new data on non-hodgkin lymphoma.
December 4, 2008... " The major cause of death in aggressive lymphoma is relapse or nonresponse to initial therapy. Lenalidomide has activity in a variety of hematologic malignancies, including non-Hodgkin's lymphoma (NHL)," researchers in the United States report...

Researchers at Zhejiang University target non-langerhans-cell histiocytosis.
December 4, 2008... "Rosai-Dorfman disease (RDD) is an idiopathic histiocytic proliferation affecting the lymph nodes. Isolated intracranial RDD is rare and usually appears as a well-defined, dural-based lesion without lymphadenopathy," scientists writing in the...

Researchers' work from University of Miami focuses on perfusion.(Clinical report)
December 4, 2008... "A prehospital trial in trauma patients has been proposed to evaluate Hemopure (hemoglobin glutamer-250 [bovine], hemoglobin-based oxygen carrying compound [HBOC]-201, Biopure). We tested the hypothesis that HBOC-201 would improve...

Recent studies by H. Wasserstrom and co-authors add new data to pneumococcal disease findings.
December 4, 2008... "Splenectomized patients are susceptible to bloodstream infections with encapsulated bacteria, potentially due to loss of blood filtering but also defective production of anticarbohydrate Ab. Recent studies propose that a lack of Ab is related...

New sclerosing cholangitis study results reported from University of Heidelberg.(Report)
December 4, 2008... "Secondary sclerosing cholangitis (SSC) is a chronic cholestatic disorder caused by mechanical, infectious, toxic, or ischemic factors. A new variant of SSC occurring after long-term treatment in intensive care units (ICU) has been recently...

Data from A.E. Jones and colleagues advance knowledge in sepsis.
December 4, 2008... According to a study from the United States, "Quantitative resuscitation consists of structured cardiovascular intervention targeting predefined hemodynamic end points. We sought to measure the treatment effect of quantitative resuscitation on...

Data from John Hunter Hospital advance knowledge in sepsis.(Report)
December 4, 2008... According to a study from Newcastle, Australia, "Splenectomy is associated with a lifelong increase in the risk of sepsis. The aim of this study was to determine the level of knowledge of patients who have undergone splenectomy within an...

Investigators at Sutcu Imam University release new data on sepsis.(Report)
December 4, 2008... "This study was designed to compare the effect of pretreatment with N-acetylcysteine (NAC) and beta-glucan (beta GLU) on inflammatory response in a rat model of sepsis. The study was performed in the animal laboratory of the Kahramanmaras Sutcu...

New sepsis research from University of Western Australia described.
December 4, 2008... "Polymorphisms within the gene encoding macrophage migration inhibitory factor (MIF) have been associated with susceptibility to inflammatory diseases such as rheumatoid arthritis and increased risk of developing sepsis. We investigated the...

Recent findings from J.M. Huston and co-authors highlight research in sepsis.(Report)
December 4, 2008... According to recent research from the United States, "High mobility group box 1 (HMGB1) is a critical mediator of lethal sepsis. Previously, we showed that apoptotic cells can activate macrophages to release HMGB1." "During sepsis,...

Recent findings from University of Jena highlight research in sepsis.(Survey)
December 4, 2008... In this recent report, researchers in Jena, Germany conducted a study "To simultaneously determine perceived vs. practiced adherence to recommended interventions for the treatment of severe sepsis or septic shock. One-day cross-sectional...

Research in the area of sepsis reported from Brussels Free University.
December 4, 2008... According to a study from Brussels, Belgium, "IntroductionSepsis remains a common problem in critically ill patients. Considerable advances have been made in our understanding of the pathophysiology of sepsis and recent years have seen a surge...

Scientists at Trinity College discuss research in sepsis.
December 4, 2008... According to a study from Dublin, Ireland, "Tumour necrosis factor-alpha (TNF alpha) has been implicated in the pathogenicity of severe sepsis by both genetic association studies and animal models. Conflicting functional data have emerged in...

Studies from China Agricultural University yield new information about sepsis.(Report)
December 4, 2008... According to a study from Beijing, People's Republic of China, "Sepsis remains a major health concern across the world. The effects of stress on host resistance to sepsis are still not very clear." "To explore the effects of chronic stress...

Studies from D. Galpern and co-researchers update current data on sepsis.(Report)
December 4, 2008... "Central line associated bloodstream infections occur commonly and are a potentially preventable source of morbidity in the critical care setting. The purpose of this study was to find a way to decrease central line-associated bloodstream...

Studies from Miami Children's Hospital yield new data on sepsis.(Clinical report)
December 4, 2008... According to recent research published in the journal Critical Care Medicine, "Hypercapnia is known to modulate inflammation in lungs. However, the effect of hypocapnia and hypercapnia on blood cytokine production during sepsis is not well...

Study findings on sepsis are outlined in reports from University of Tokyo, Medical Department.(Report)
December 4, 2008... According to recent research from Hongo, Japan, "Cytosolic phospholipase A(2)alpha (cPLA(2)alpha) is one of the key enzymes in lipid mediator generation. It preferentially hydrolyzes arachidonoyl-phospholipid in response to cellular stimuli,...

New hemoglobinopathy findings from Tel-Aviv University, Cancer Research Center described.
December 4, 2008... Current study results from the report, 'Regulation of iron absorption in hemoglobinopathies,' have been published. "Beta-thalassemia and sickle cell anemia (SCD) represent the most common hemoglobinopathies caused, respectively, by deficient...

Researchers from University Hospital report recent findings in life sciences.
December 4, 2008... Fresh data on life sciences are presented in the report 'Cellular processes in sepsis.' According to recent research from Zurich, Switzerland, "Sepsis, the systemic inflammatory response to an infection, is an increasingly common condition. It...

New liver failure therapy study results from Virginia Commonwealth University described.
December 4, 2008... Fresh data on liver failure are presented in the report 'Critical management decisions in patients with acute liver failure.' "Few admissions to the ICU present a greater clinical challenge than the patient with acute liver failure (ALF), the...

New sepsis therapy findings from Turkiye Yuksek Ihtisas Hospital described.(Report)
December 4, 2008... New investigation results, 'Role of activated protein C on wound healing process in left colonic anastomoses in the presence of intra-abdominal sepsis induced by cecal ligation and puncture: an experimental study in the rat,' are detailed in a...

Research from Henry Ford Hospital, Department of Emergency Medicine yields new findings on sepsis therapy.
December 4, 2008... A new study, 'Improving outcomes for severe sepsis and septic shock: tools for early identification of at-risk patients and treatment protocol implementation,' is now available. "Sepsis is a significant problem, and septicemia is the 10th...

Study findings on sickle cell anemia are outlined in reports from Akdeniz University, Department of Biochemistry.
December 4, 2008... Scientists discuss in 'Modulation of redox pathways in neutrophils from sickle cell disease patients' new findings in sickle cell anemia. According to recent research from Antalya, Turkey, "Interaction of nitric oxide (NO) with enzymatic...

New thalassemia genetics data have been reported by researchers at Hadassah University, Hematology Department.
December 4, 2008... Investigators publish new data in the report 'Genetic modifiers in hemoglobinopathies.' According to a study from Ein Kerem, Israel, "Hereditary anemias show considerable variation in their clinical presentation. In some cases, the causes of...

Reports outline thalassemia therapy study findings from University of North Carolina, Division of Hematology-Oncology.
December 4, 2008... Investigators publish new data in the report 'Hypercoagulability in sickle cell disease and beta-thalassemia.' "Sickle cell disease (SCD) and beta-thalassemia (also referred to as beta-thalassemia) are common hereditary hemoglobinopathies with...

Scientists at University of Central Florida release new data on administrative science.
December 4, 2008... "Catastrophic disasters require additional leadership capabilities because extreme events overwhelm local capabilities and damage emergency response systems themselves," scientists in the United States report (see also Administrative Science)....

Studies from University of Louisville have provided new data on administrative science.(Report)
December 4, 2008... "This research updates existing literature that describes the nature of public affairs programs. A profile of the top 50 public affairs programs, according to rankings from US," scientists in the United States report (see also Administrative...

Yonsei University publishes research in administrative science.
December 4, 2008... "The significance and the role of leadership in organizations and institutions have been widely discussed but not well understood. Much of the previous Literature is limited to leadership practices and education as well as to the American...

Studies from University of Erlangen have provided new information about aneurysm.
December 4, 2008... According to recent research published in the American Journal of Neuroradiology, "Angiographic CT (ACT) produces CT-like images within minutes in the angiography suite." "We present the cases of 2 patients with intraprocedural aneurysmal...

Study results from Mayo Clinic, Medical Department provide new insights into aneurysm.
December 4, 2008... "The molecular characteristics of the pathophysiology of saccular aneurysms remain poorly understood. The purpose of the current study was to investigate the expression of various groups of genes at different stages of aneurysm age in...

Findings from J. Kpodonu and co-authors broaden understanding of angiology.
December 4, 2008... In this recently published article, scientists in the United States conducted a study "To evaluate the feasibility and safety of thoracic endografting in the octogenarian population. Between February 2000 and August 2005, 249 patients with a...

New angiology study findings reported from Seoul National University.(Report)
December 4, 2008... "The purpose of this study was to introduce a new high-definition flow (HDF) Doppler technique and to compare its performance with those of color Doppler ultrasonography (CDU) and power Doppler ultrasonography (PDU) for assessment of hepatic...

Researchers at Brunel University publish new data on angiology.
December 4, 2008... "This numerical study aims to investigate the capacity of the circle of Wills (CoW) to provide collateral blood supply for patients with unilateral carotid arterial stenosis," scientists writing in the Journal of Biomechanics report (see also...

Studies from George Washington University provide new data on angiology.
December 4, 2008... According to recent research from the United States, "The exact process by which blunt trauma to the aorta produces a typical characteristic lesion set of primary, transverse, intimal injury remains unknown. The likely cause is a combination of...

Data from Kyoto University provide new insights into angioplasty.
December 4, 2008... According to recent research from Kyoto, Japan, "We report here a successful case of balloon angioplasty for a stenosis of the pulmonary artery after lung transplantation. A 49-year-old patient with end stage diffuse bronchiectasis with...

New angiotensins findings from D. Sacristan and co-authors described.
December 4, 2008... "Olmesartan medoxomil is a new angiotensin II receptor blockers (ARB) which exhibits pleiotropic effects that are not fully understood. Our aims were: i) to determine the effect of Olmesartan medoxomil on blood pressure, lipid profile and renal...

New anxiety disorders study results reported from Wayne State University.
December 4, 2008... "The study objective was to estimate the prevalence and correlates of antidepressant use by black and white Americans. Data from the Collaborative Psychiatric Epidemiology Surveys (CPES) were analyzed to calculate nationally representative...

New assisted reproduction study findings have been reported by L. Scott and colleagues.
December 4, 2008... According to a study from the United States, "Oocyte and embryo selection are not highly successful, with fewer than 10% of oocytes in assisted reproduction resulting in a delivery. Techniques for oocyte and embryo selection rely on highly...

Research on assisted reproduction reported by scientists at University of Bonn.
December 4, 2008... According to a study from Bonn, Germany, "Embryo viability is a key element for success in assisted reproduction. Since the beginning of the era of assisted reproduction treatment, embryo viability was mostly considered to be a function of...

Research data from University of London, Imperial College update understanding of atherosclerosis.
December 4, 2008... "Atherosclerosis is a chronic inflammatory disease of arteries. It is triggered by proinflammatory mediators which induce adhesion molecules (eg, vascular cell adhesion molecule [VCAM]-1) in endothelial cells (ECs) by activating p38 and c-Jun...

Research from University of Pittsburgh in the area of atorvastatin published.
December 4, 2008... "Using mixed lymphocyte reaction (MLR), the effect of atorvastatin on proliferation of human and baboon peripheral blood mononuclear cells (PBMCs) and human CD4(+) T cells in response to wild-type (WT) and alpha-1,3-galactosyltransferase...

Studies from University of Rouen further understanding of atrial fibrillation.(Clinical report)
December 4, 2008... "The objective was to determine the main parameters taken into account for the decision of antithrombotic treatment of atrial fibrillation (AF) by vitamin K antagonist or aspirin. This was a prospective clinical study of four clinical services...

Research from University of Alcala, Medical Department in attention deficit hyperactivity disorder provides new insights.
December 4, 2008... " We have carried out a bibliometric analysis of scientific publications related to attention-deficit hyperactivity disorder (ADHD) and its pharmacological treatment over the period 1980-2005. We selected (in EMBASE and MEDLINE databases)...

Research in the area of autoimmune disease reported from University of North Carolina.
December 4, 2008... According to recent research from the United States, "Cutaneous autoimmune blistering diseases are associated with tissue injury and fluid accumulation within the skin. The initial trigger for the organ-specific damage is autoantibodies...

Research reports on autoimmune disease from A.G. Gianoukakis and colleagues provide new insights.
December 4, 2008... "Graves' disease, an autoimmune process associated with thyroid dysfunction, can also manifest as remodeling of orbital connective tissue. Affected tissues exhibit immune responses that appear to be orchestrated by resident cells and those...

Study findings from University of Florence broaden understanding of autopsy.
December 4, 2008... According to recent research from Florence, Italy, "The unique case of a 50-year-old known alcoholic whose corpse was exhumed 27 years after death is reported. The man apparently committed suicide by hanging, but many years later the case was...

St. Francis Xavier University reports research in biomedicine.
December 4, 2008... "Technology has become synonymous with medical intervention, particularly in hospital settings in the Western world. Much money is spent on the invention, design, and implementation of biomedical technologies," scientists in Antigonish, Canada...

Data on biopsy described by researchers at Northwestern University.(Report)
December 4, 2008... In this recent report published in the Journal of Vascular and Interventional Radiology, researchers in the United States conducted a study "To test the hypothesis that transcatheter arterial embolization (TAE) induces expression of...

Investigators at Duke University zero in on blood pressure.(Clinical report)
December 4, 2008... "Observational and clinical studies suggest that high protein intake, particularly protein from plant sources, might reduce blood pressure (BP). To examine the association of dietary protein with BP, we analysed data from PREMIER, an 18-month...

Report summarizes blood pressure study findings from University of Washington.(Report)
December 4, 2008... According to recent research from the United States, "Numerous studies have shown that high olive oil intake reduces blood pressure (BP). These positive effects of olive oil have frequently been ascribed to its minor components, such as...

Recent studies from Innsbruck Medical University add new data to bone research.
December 4, 2008... According to a study from Innsbruck, Austria, "Endochondral bone formation, the process by which most parts of our skeleton evolve, leads to the establishment of the diaphyseal primary (POC) and epiphyseal secondary ossification centre (SOC) in...

Research by S.M. Ibrahim and colleagues in bradycardia provides new insights.
December 4, 2008... "The case is reported of a 30-year-old multigravida, with insignificant history and stable vital signs, admitted to the labour room for normal vaginal delivery of twins. She received combined spinal epidural analgesia (bupivacaine plus...

New cancer findings from P. Tan and co-researchers published.
December 4, 2008... "Identifying the complete repertoire of genes and genetic variants that regulate the pathogenesis and progression of human disease is a central goal of post-genomic biomedical research. In cancer, recent studies have shown that genome-wide...

Research in the area of cancer reported from M.F. Bevans and colleagues.
December 4, 2008... "Goals of work Despite advances in allogeneic hematopoietic stem cell transplantation (HSCT), post-transplant complications are common, and patients' symptom experience has not been well documented. To characterize the symptom experience of...

Studies conducted at M.I. Dawson et al on cancer recently published.
December 4, 2008... According to recent research from the United States, "(E)-4-[3-(1-Adamantyl)-4'-hydroxyphenyl]-3-chlorocinnamic acid (3-Cl-AHPC) induces the cell-cycle arrest and apoptosis of leukemia and cancer cells. Studies demonstrated that 3-Cl-AHPC bound...

Studies from McGill University describe new findings in cancer.
December 4, 2008... "As cancer treatment outcomes improve, the number of women with cancer seeking fertility preservation increases. Currently, embryo/oocyte cryopreservation appears to provide the best fertility preservation option," investigators in Montreal,...

University of Tubingen details research in cancer.
December 4, 2008... According to recent research from Tubingen, Germany, " Shaping immune responses to prevent tumor-induced tolerance or transplant rejection after solid organ transplantation is a permanently expanding field of research. Immunological tolerance,...

Reports outline capillary electrophoresis research from University of Vienna.
December 4, 2008... According to recent research published in the Journal of Pharmaceutical and Biomedical Analysis, "A capillary electrophoresis (CE) method for testing the stability of a novel oral anticancer metallodrug, tris(8-quinolinolato)gallium(III)...

Studies in the area of cardiomegaly reported from National University.
December 4, 2008... "The aim of this work was to assess the possible correlation between oxidative damage and the development of cardiac hypertrophy in heart tissue from young (40-d-old) and older (4-, 11 - and 19-month-old) spontaneously hypertensive rats (SHR)...

Reports outline cardiopulmonary bypass research from Seoul National University.(Report)
December 4, 2008... "This study evaluated and compared the risks and effects to the inflammatory response of low- and high-dose aprotinin regimens. Between January and June 2006, patients scheduled for cardiac surgery using cardiopulmonary bypass were enrolled and...

Research from T.R. Rani and colleagues has provided new data on cardiopulmonary bypass.
December 4, 2008... According to recent research from Hyderabad, India, "THE ACTIVATED COAGULATION TIME (ACT) is commonly used to monitor heparin anticoagulation during cardiac surgery with cardiopulmonary bypass (CPB). Prolongation of the ACT can also result from...

Research from University of Genoa, Medical Department yields new findings on cardiovascular risk.(Report)
December 4, 2008... "Global cardiovascular risk is a new approach which allows the physicians to quantitate the prognosis of the patients. It is therefore possible that a score, based on the major cardiovascular risk factors, is correlated with some degree of...

Data on cerebral blood flow described by G. Miekisiak et al.(Report)
December 4, 2008... According to recent research from the United States, "We evaluated cerebral blood flow by laser Doppler during 30 secs of hypoxia (0.10 FiO(2)) in anesthetized, ventilated adenosine 2a receptor knockout (A2aR KO) and wild-type (WT) mice to test...

Reports from Z. Morise and colleagues advance knowledge in cholangio cancer.
December 4, 2008... "Intrahepatic cholangiocarcinoma (ICC) is a relatively rare malignancy arising from the biliary epithelium. Prognosis is typically poor," scientists in Japan report (see also Cholangio Cancer). "Currently, aggressive surgical resection is...

Findings from Dalhousie University broaden understanding of cholecystitis.
December 4, 2008... "Gallbladder perforation is a rare condition even in patients affected by acute cholecystitis. Most patients who present with gallbladder perforations are diagnosed preoperatively by radiologic imaging," researchers in Halifax, Canada report...

Scientists at AstraZeneca detail research in chromatography.
December 4, 2008... According to recent research from Macclesfield, the United Kingdom, "The non-selective beta-adrenergic receptor antagonist propranolol [1-(isopropylamino)-3-(1-naphthoxy)-2-propanol] is metabolised extensively in vivo. Enumerating and...

Research from University of Washington has provided new information about chronic lymphocytic leukemia.(Clinical report)
December 4, 2008... " We reported encouraging early results of allogeneic hematopoietic cell transplantation (HCT) after nonmyeloablative conditioning in 64 patients who had advanced chronic lymphocytic leukemia (CLL). Here, we have extended the follow-up to a...