Blood Weekly articles from August 2008

Blood Weekly archives from August 2008

Water-diffusion technology identifies brain regions damaged by prenatal alcohol exposure.
August 7, 2008... Scientists know that children with Fetal Alcohol Spectrum Disorder (FASD) often have structural brain damage. Yet little is known about how white matter connections, and deep gray matter structures that act as relay stations, are affected in...

'Statins' linked to improved survival in kidney transplant recipients.
August 7, 2008... For patients receiving kidney transplants, treatment with cholesterol-lowering "statin" drugs may lead to longer survival, reports a study in the November 2008 Journal of the American Society of Nephrology (JASN) (see also American Society of...

Discovery of a mechanism that regulates cell movement.
August 7, 2008... A study performed by researchers at the Institute for Research in Biomedicine (IRB Barcelona), in collaboration with researchers at the Instituto de Biologia Molecular of the CSIC, reveal a mechanism that controls the movement of cells in a...

Male kidneys for men only?
August 7, 2008... The gender of donor and recipient plays a larger role in kidney transplants than previously assumed. Female donor kidneys do not function as well in men u due to their smaller size. Women have a higher risk of rejecting a male donor kidney....

Discovery of a new signaling mechanism may lead to novel anti-inflammatory therapy.
August 7, 2008... A team of researchers at the University of California, San Diego School of Medicine has uncovered a new signaling mechanism used to activate protein kinases that are critical for the body's inflammatory response. Their work will be published in...

Study results from K. Sai et al provide new insights into cancer.
August 7, 2008... According to recent research from Tokyo, Japan, "Background and purpose Cytochrome P450 3A4 (CYP3A4) converts an anticancer prodrug, irinotecan, to inactive metabolites such as APC. However, the contribution of CYP3A4 genetic polymorphisms to...

Research from R. Soundravally and co-researchers yields new findings on dengue fever.(Report)
August 7, 2008... According to a study from Pondicherry, India, "Antigen peptides are actively transported across the endoplasmic reticulum by the transporters associated with antigen presentation (TAP). TAP genes polymorphism could influence the selection...

Studies in the area of dialysis reported from P.M. Palevsky and co-researchers.
August 7, 2008... According to a study from the United States, "The optimal intensity of renal-replacement therapy in critically ill patients with acute kidney injury is controversial. We randomly assigned critically ill patients with acute kidney injury and...

New drug resistance study findings recently were published by researchers at Kyushu University.(Report)
August 7, 2008... According to recent research from Fukuoka, Japan, "Stenotrophomonas maltophilia (previously named Xanthomonas maltophilia) is an aerobic, nonfermentive, Gram-negative bacillus that is widespread in the environment. It is considered to be an...

Research reports on enzyme research from A.A. Birukova and colleagues provide new insights.
August 7, 2008... "Acute lung injury, sepsis, lung inflammation, and ventilator-induced lung injury are life-threatening conditions associated with lung vascular barrier dysfunction, which may lead to pulmonary edema. Increased levels of atrial natriuretic...

Research from University of Leipzig in the area of life sciences published.
August 7, 2008... "The antimicrobial activity of new tetracationic and water-soluble meso-substituted tetrahydroporphyrin tetratosylat (BL1065) and of dicationic water-soluble chlorine e6 Photolon (TM) (BLC1013) is described. The dark toxicity and...

Simple flow-based total nucleated cell differential.
August 7, 2008... A new method published in Cytometry part B uses DRAQ5 to gate all nucleated cells, FlowCount beads, a panel of 6 antibodies in 4 clusters and the 5 fluorescence channels plus forward and side scatter on the Beckman Coulter FC500 flow cytometer...

Studies from Novo Nordisk in the area of life sciences published.
August 7, 2008... "Recombinant activated factor VIIa (rFVIIa) is indicated for on-demand treatment of bleeding and the prevention and treatment of surgical bleeding in patients with hemophilia A or B who have antibodies to coagulation factors VIII or IX. The...

Report summarizes mesothelioma study findings from University of Rochester.
August 7, 2008... "Malignant pleural mesothelioma (MPM) is a rare cancer that rnetastasizes to mediastinal lymph nodes (MLNs). The diagnosis of MPM metastatic to MLNs may not be straightforward," researchers in the United States report (see also Mesothelioma)....

New findings from Nagoya University in the area of myelodysplastic syndrome published.
August 7, 2008... "P53 mutation has been reported in various solid tumors, acute leukemia and myelodysplastic syndrome (MDS), but the diagnostic significance of p53 in MDS remains to be determined. The purpose of the present paper was to examine p53 mutation and...

Study findings on myeloma are outlined in reports from M.S. Bhandari and colleagues.
August 7, 2008... "Multiple malignancies in the same patient are unusual. This is particularly true for patients with hematologic malignancies who have a concomitant solid tumor," researchers in the United States report (see also Myeloma). "We report the...

Studies from Showa University provide new data on neutropenia.(Report)
August 7, 2008... According to recent research published in the journal Cancer Chemotherapy and Pharmacology, " Fever occurring in a neutropenic patient remains a common life-threatening complication of cancer chemotherapy, and febrile neutropenia (FN) is...

New Parkinson disease research from Z. Ganor et al outlined.
August 7, 2008... "Mutations in GBA and LRRK2 genes have been implicated in Parkinson disease (PD), particularly in Ashkenazi Jews. An Israeli Ashkenazi cohort of 420 patients with PD, 333 elderly controls, and 3,805 young controls was screened for eight GBA...

Research on pharmacokinetics detailed by P.M. Lorusso and co-authors.
August 7, 2008... According to a study from the United States, " This phase I study assessed the safety, optimally tolerated regimen (OTR), pharmacokinetics, pharmacodynamics, and preliminary clinical activity of lapatinib and docetaxel in patients with advanced...

Telescope Embedded in Spectacle Lens Promises to Make Driving Easier for Visually Impaired.
August 7, 2008... Glasses embedded with a telescope promise to make it easier for people with impaired vision to drive and do other activities requiring sharper distance vision. Schepens Eye Research Institute scientists describe the advantages of these...

Studies from University of Milan in the area of sepsis described.
August 7, 2008... According to recent research published in the journal Transplantation Proceedings, "Severe sepsis in transplant recipients results in an extremely high morbidity mortality rate. Microvascular alterations play an important role in the...

Studies from W.C. Cirocco and colleagues reveal new findings on sepsis.
August 7, 2008... "Stapled hemorrhoidopexy (SH) was conceived and developed in Europe. Over the past decade, there have been reports of severe, life-threatening complications and 2 deaths," researchers in the United States report (see also Sepsis). "These...

Study data from University of Tennessee provide new insights into sepsis.
August 7, 2008... "Intra-abdominal sepsis (IAS) following pancreatectomy is associated with the need for therapeutic intervention and may result in mortality. We retrospectively reviewed patients developing IAS following elective pancreatectomy," researchers in...

New sickle cell anemia data have been reported by K.B. Taori and co-authors.
August 7, 2008... According to recent research published in the American Journal of Roentgenology, "The purpose of our study was to detect changes in renovascular resistance through renal Doppler indexes in young sickle cell disease patients with normal routine...

Research from University of Vermont, Medical Department provide new insights into subarachnoid hemorrhage.
August 7, 2008... According to recent research published in the journal Stroke, "Cerebral vasospasm after subarachnoid hemorrhage ( SAH) is a major contributor to mortality and morbidity after aneurysm rupture. Recently, R-type voltage-dependent Ca2+ channel (...

Reports outline surgery research from St. Joseph University.(Report)
August 7, 2008... According to a study from Beirut, Lebanon, "The purpose of this study was to evaluate the safety of femoral arterial pressure monitoring in cardiac surgery. Prospective, observational study." "Cardiac surgery unit (CSU) in a university...

Data on thrombocytopenic purpura reported by researchers at Monash University.(Report)
August 7, 2008... "Receptors on platelets that contain immunoreceptor tyrosine-based activation motifs (ITAMs) include collagen receptor glycoprotein (GP) VI, and Fc gamma RIIa, a low affinity receptor for immunoglobulin (Ig) G. We examined the function of GPVI...

Studies by T. Yuri and co-authors describe new findings in thrombocytopenic purpura.
August 7, 2008... "A 64-year-old Japanese woman suffering from idiopathic thrombocytopenic purpura was treated with prednisolone. During the course of steroid withdrawal she developed parotid gland enlargement and cervical lymph node swelling with multiple...

Studies from S. Shetty et al provide new data on thrombophilia.
August 7, 2008... According to a study from Bombay, India, "The clinical phenotype in hemophilia generally cot-relates with the type of mutations." "We studied 16 patients with severe hemophilia A (factor VIII and factor VIII:Ag The researchers...

New transplantation data have been reported by J. Junginger and co-authors.
August 7, 2008... According to recent research from Tubingen, Germany, "The short cold ischemic tolerance of the gut is a major problem in small bowel transplantation. We have shown that intestinal lipid administration is beneficial during systemic inflammation...

Findings from St. Thomas' Hospital provide new insights into vasculitis.
August 7, 2008... According to recent research from London, the United Kingdom, "Cardiovascular disease may be increased in patients with systemic vasculitides (SV). The Ankle-Brachial Pressure Index (ABPI) is a non-invasive tool for the assessment of...

New findings from University of Texas, M. D. Anderson Cancer Center in the area of acute lymphoblastic leukemia therapy published.(Report)
August 7, 2008... Research findings, 'Secondary myelodysplastic syndrome in a patient with Philadelphia-positive acute lymphoblastic leukemia after achieving a major molecular response with hyperCVAD plus imatinib mesylate,' are discussed in a new report. "The...

Scientists at Scientific Institute, Division of Pediatrics describe research in autoinflammatory disease.
August 7, 2008... A new study, 'Diagnosis and management of autoinflammatory diseases in childhood,' is now available. "Autoinflammatory diseases are a group monogenic inflammatory conditions characterized by an early onset during childhood. Under the term...

Studies from M.L. Slovak and colleagues yield new information about life sciences.(Conference notes)
August 7, 2008... Current study results from the report, 'International Working Group on MDS cytogenetics: October 2007 meeting report,' have been published. According to recent research from the United States, "The inaugural meeting of the International Working...

Study data from National Medical Center update understanding of myelodysplastic syndrome cell biology.
August 7, 2008... Investigators publish new data in the report 'Functional analysis of myelodysplastic syndromes-derived mesenchymal stem cells.' According to recent research from Mexico, "Two different reports, including one from our own group, have recently...

Researchers from University of Rochester detail findings in myelodysplastic syndrome risk factors.
August 7, 2008... Scientists discuss in 'Is there an entity of chemically induced BCR-ABL-positive chronic myelogenous leukemia' new findings in myelodysplastic syndrome. According to recent research from the United States, "Advances in the therapy of malignancy...

Recent studies from Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins add new data to myelodysplastic syndrome therapy.
August 7, 2008... Data detailed in 'Myeloablative allogeneic bone marrow transplant using T cell depleted allografts followed by post-transplant GM-CSF in high-risk myelodysplastic syndromes' have been presented. According to recent research from the United...

Researchers from Cedars-Sinai Medical Center, Division of Hematology detail new studies and findings in the area of myeloid leukemia therapy.(Report)
August 7, 2008... Scientists discuss in 'Cucurbitacin B induces differentiation, cell cycle arrest, and actin cytoskeletal alterations in myeloid leukemia cells' new findings in myeloid leukemia. "Cucurbitacins have long been utilized for their abortifacient and...

Scientists at University of North Texas describe research in acute hypotension.(Report)
August 7, 2008... According to a study from the United States, "The effect of antihypertensive drugs on autonomic neural control of the cerebral circulation remains unclear. This study was designed to compare middle cerebral artery mean blood velocity responses...

New acute leukemia data have been reported by W. Stock and co-authors.
August 7, 2008... "A phase I study was performed to determine the safety and pharmacokinetics of XK469R in patients with refractory acute leukemia. The study aimed to determine the maximum tolerated dose (MTD) and dose limiting toxicity (DLT) of XK469R given...

Data on anesthesia described by J. Fazakas et al.
August 7, 2008... "Although the contraindications for thoracic epidural anesthesia (TEA) are well defined, the debate continues about whether TEA improves outcomes. Pro and con trials and a metaanalysis in the past have yielded equivocal results; they did not...

New data from Army illuminate research in aneurysm.
August 7, 2008... According to recent research from Beijing, People's Republic of China, " Due to their location, large and giant intracavernous and paraclinoid aneurysms remain a challenge for vascular neurosurgeons. We identified characteristics, surgical...

Study findings from University of Washington broaden understanding of aneurysm.
August 7, 2008... According to recent research from the United States, "Bronchial artery aneurysms occur rarely, but they are potentially life threatening and require treatment to avoid rupture and other complications. A 37-year-old man, who was otherwise...

Data on angiology discussed by M.L. Antonova and colleagues.
August 7, 2008... According to recent research published in the journal Annals of Biomedical Engineering, "The arterial wall viscoelasticity plays an essential role in the vascular responsiveness to vasoactive drugs or pathologies. The aim of this investigation...

New research on angiology from M.A.D. Vente and co-authors summarized.(Report)
August 7, 2008... " The aim of this study is to evaluate the toxicity of holmium-166 poly(L-lactic acid) microspheres administered into the hepatic artery in pigs. Healthy pigs (20-30 kg) were injected into the hepatic artery with holmium-165-loaded...

Studies from Miyazaki University, Medical Department provide new data on angiology.
August 7, 2008... "Smooth muscle cell (SMC)-rich intima is a morphological feature of atherosclerotic lesions that is observed in eroded plaque and spastic arteries. Arteries with SMC-rich intima are susceptible to vasoconstriction or vasospasm against some...

Studies from W.C. Methodiusngwodo and colleagues provide new data on angiology.(Report)
August 7, 2008... According to recent research from the United States, "We have replaced aortography and open thoracic surgery to diagnose and treat blunt traumatic thoracic aortic disruption (TTAD) in favor of CT angiography (CTA) and endovascular repair. The...

Recent findings from D.M. Rabi and co-authors highlight research in angiotensins.
August 7, 2008... "Clinical practice recommendations for hypertension do not make recommendations specific to men or women. However, the sex hormones appear to modulate differently the renin-angiotensin system (RAS), which plays a central role in the regulation...

Reports outline antibiotics study results from S. Roy et al.
August 7, 2008... According to a study from Calcutta, India, "Development of biomaterials, which are inherently antibacterial having broad-spectrum activity against both Gram-positive and Gram-negative bacteria with considerable biocompatibility, is of...

Research from Leiden University yields new findings on antibiotics.(Report)
August 7, 2008... According to recent research from Netherlands, "Chitosan, a biodegradable and biocompatible polymer, has attracted great attention in the pharmaceutical and biomedical fields especially due to its properties to reversibly open the tight...

Research from University of Pennsylvania reveals new findings on aortic dissection.(Report)
August 7, 2008... "Conventional open repair of acute complicated type B aortic dissection is associated with significant morbidity and mortality. This study examined the results of thoracic endovascular aortic repair (TEVAR) in acute type B aortic dissection...

Nihon University publishes research in apoptosis.(Report)
August 7, 2008... "Cerebral ischemia followed by oxygen reperfusion induced apoptosis in hippocampal neurons in the stroke-prone spontaneously hypertensive rat (SHRSP) but not in Wistar Kyoto rats (WKY). We investigated whether...

Research findings from W. Pickering et al update understanding of apoptosis.
August 7, 2008... "Coagulation has an absolute requirement for macromolecular complexes to be assembled on a negatively charged phospholipid (PL) surface. Previously, we reported that malignant T-lymphoblastoid cells have the ability to support procoagulant...

Studies from Hong Kong University of Science & Technology reveal new findings on apoptosis.
August 7, 2008... According to recent research from Hong Kong, People's Republic of China, "Accumulating evidence indicates that deregulation of cyclin-dependent kinase 5 (Cdk5) activity is associated with apoptosis in various neurodegenerative disease models....

Findings in artificial chromosomes reported from University of Leeds.
August 7, 2008... According to recent research from Leeds, the United Kingdom, "Genome scans using large numbers of randomly selected markers have revealed a small proportion of loci that deviate from neutral expectations and so may mark genomic regions that...

Researchers from University of Liege describe findings in artificial chromosomes.
August 7, 2008... "Koi herpesvirus (KHV) is the causative agent of a lethal disease in koi and common carp. In the present study, we describe the cloning of the KHV genome as a stable and infectious bacterial artificial chromosome (BAC) clone that can be used to...

Research reports on atherosclerosis from M. Mayr and colleagues provide new insights.
August 7, 2008... "We have recently demonstrated that stem cell antigen 1-positive (Sca-1(+)) progenitors exist in the vascular adventitia of apolipoprotein E-deficient (apoE(-/-)) mice and contribute to smooth muscle cell (SMC) accumulation in vein graft...

Research on autoimmune disease published by scientists at University of Basel.
August 7, 2008... "Many of the clinical, histological and serological manifestations of chronic graft-versus-host disease (GVHD) resemble autoimmune disease (AD), and although the differences are significant, they may be more semantic than biological. Indeed,...

New data from X. Mao et al illuminate research in B-cell lymphoma.(Report)
August 7, 2008... " Primary cutaneous B-cell lymphoma (PCBCL) consists mainly of primary cutaneous marginal zone B-cell lymphoma (PCMZL), primary cutaneous follicle centre lymphoma (PCFCL) and primary cutaneous large B-cell lymphoma, leg type (PCLBCL-LT). The...

Research findings from University of California update understanding of B-cell lymphoma.
August 7, 2008... "In an initial epigenetic characterization of diffuse large B-cell lymphoma (DLBCL), we evaluated the DNA methylation levels of over 500 CpG islands. Twelve CpG islands (AR, CDKN1C, DLC1, DRD2, GATA4, GDNF, GRIN2B, MTHFR, MYOD1, NEUROD1,...

Research from Showa University in B-cell lymphoma provides new insights.
August 7, 2008... "Described herein is a case of thymic extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue. Using immunohistochemical double staining it was found that most of the thymic lymphoid follicles in this case possessed...

Researchers at University of Melbourne target B-cell lymphoma.
August 7, 2008... According to recent research from Parkville, Australia, "Primary breast lymphoma is a rare entity. Furthermore, extranodal marginal zone B-cell lymphoma affecting the breast is exceedingly rare." "We report a unique case of invasive...

Study findings from C. Demirkesen et al provide new insights into Behcet disease.
August 7, 2008... According to a study from Istanbul, Turkey, "Adhesion molecules have a role in many vasculitic disorders. Our aim was to evaluate the status of adhesion molecules in nodular lesions of Behcet syndrome (BS) and compare them with results,for the...

New biomedicine research from C.M. Chanaud and colleagues discussed.(Conference notes)
August 7, 2008... According to recent research from the United States, "Clinical Investigators conducting biomedical research involving human participants in the U.S. are responsible for the content of the consent document(s) and for the conduct of the informed...

Reports summarize blood pressure research from University of Florence.(Report)
August 7, 2008... "Objectives The present study investigated whether central blood pressure (BP) predicts cardiovascular (CV) events better than brachial BP in a cohort of normotensive and untreated hypertensive elderly individuals. Limited and conflicting data...

University of California, Medical Department reports research in blood pressure.
August 7, 2008... "Chromogranin A (CHGA) is stored and released from the same secretory vesicles that contain catecholamines in chromaffin cells and noradrenergic neurons. We had previously identified common genetic variants at the CHGA locus in several human...

New findings from Semyung University in the area of bone marrow published.(Report)
August 7, 2008... "Angelicae Gigantis Radix (AGR) is one of the most widely used herbal medications. AGR is the dried root of Angelica gigas Nakai (Umbelliferae), which is known as Korean angelica," scientists writing in the journal Phytotherapy Research report...

Research results from J. Zhang and co-authors update knowledge of bone marrow.(Report)
August 7, 2008... "Oligodendrocyte (OLG) damage leads to demyelination, which is frequently observed in ischemic cerebrovascular diseases. In this study, we investigated the effect of bone marrow stromal cells (BMSCs) on OLGs subjected to oxygen-glucose...

New bone research from Federal University outlined.(Report)
August 7, 2008... "A major problem on modern dentistry is the recovery of bone defects of different etiologies. Biomaterials are used to improve the repair of these defects," investigators in Salvador, Brazil report (see also Bone Research). "Previous...

Reports from S. Weiner et al highlight recent research in bone research.(Report)
August 7, 2008... According to a study from the United States, "The purpose of this study was to examine the crestal bone, connective tissue, and epithelial cell response to a laser microtextured collar compared with a machined collar, in the dog model. Six...

Scientists at Medical University of Vienna detail research in bone research.
August 7, 2008... "Osteogenic cells contribute to the process of osseointegration and graft consolidation. However, whether the cells survive low oxygen tension and maintain their responsiveness to natural and therapeutic growth and differentiation factors...

Studies from University of California reveal new findings on bone research.
August 7, 2008... According to recent research published in the journal Circulation Research, "Arterial calcification is ubiquitous in vascular disease and is, in part, prevented by matrix Gla protein (MGP). MGP binds calcium ions through gamma-carboxylated...

Study results from Radboud University update understanding of bone research.
August 7, 2008... "The effect of platelet-rich plasma (PRP) on bone formation was investigated in a rabbit segmental radial defect model. The purpose of the study was to evaluate the bone inductive properties of PRP with titanium fiber mesh and autologous bone...

New bone substitutes research from Ankara University discussed.
August 7, 2008... According to recent research published in the Journal of Bioactive and Compatible Polymers, "Mesenchymal stem cells (MSCs) are multipotent progenitor cells with the ability to differentiate into osteoblasts, chondroblasts, myocytes, and...

Research from University of California in the area of brain cancer published.
August 7, 2008... In this recently published article, scientists in the United States conducted a study "To update past meta-analyses on occupational electromagnetic fields (EMF) and adult brain cancer and leukemia. We collected and evaluated all relevant 1993...

Data on breast cancer reported by researchers at University of Utah.
August 7, 2008... According to recent research from the United States, "Breast cancer survivors must manage chronic side effects of original treatment. To manage these symptoms, communication must include both biomedical and contextual lifestyle factors." ...

Findings from G. Fyrmpas and co-authors broaden understanding of breast cancer.
August 7, 2008... "We report a rare clinical presentation of breast carcinoma metastasis to the ethmoid sinuses, orbit and cavernous sinus in a 70-year-old lady with unsuspected breast carcinoma who presented with clinical features of acute ethmoiditis, orbital...

Research from University Medical Center provides new data about cardiopulmonary bypass.
August 7, 2008... "Pulmonary dysfunction presumably linked to an inflammatory response is frequent after cardiac operations using cardiopulmonary bypass (CPB) and pulmonary hypoperfusion. We previously demonstrated that active perfusion of the lungs during CPB...

Studies conducted at University of Calgary on cardiovascular disease recently published.
August 7, 2008... According to recent research from Calgary, Canada, "Increases in dietary sodium increase blood pressure, whereas emerging, evidence confirms that the reduction in dietary sodium results in reduced cardiovascular events. To estimate the effect...

Scientists at University of Pavia target celiac disease.
August 7, 2008... "Paneth cells, granulated epithelial cells located at the base of small bowel crypts, have a crucial role in innate immunity. Because controversies remain concerning Paneth cell numbers and function in celiac disease (CD), we quantified Paneth...

New cell motility research has been reported by A. Wright et al.
August 7, 2008... "Motility of cancer cells plays a critical role in tumor metastasis, and as such is a target for intervention. The motility of malignant Calu-1 human lung epithelial carcinoma cells is upregulated when placed on a human umbilical vein...

Reports from MS Center describe recent advances in Chagas disease.
August 7, 2008... "Chagas disease was an important medical and social problem in almost all of Latin America throughout the twentieth century It has been combated over a broad swath of this continent over recent decades, with very satisfactory results in terms...

Research by E. Bonhoure and colleagues in chronic myeloid leukemia provides new insights.(Report)
August 7, 2008... "We examined the involvement of sphingosine kinase-1 (SphK1), which governs the ceramide/sphingosine-1-phosphate balance, in susceptibility to imatinib of either sensitive or resistant chronic myeloid leukemia cells. Imatinib-sensitive LAMA84-s...

Research reports on circadian rhythms from University of Edinburgh provide new insights.(Report)
August 7, 2008... "Circadian rhythms control a vast array of biological processes in a broad spectrum of organisms. The contribution of circadian rhythms to the development of megakaryocytes and the regulation of platelet biology has not been defined,"...