Immunotherapy Weekly articles from September 2003

Immunotherapy Weekly archives from September 2003

Targeted DNA vaccine may reverse disease.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- Stanford University Medical Center researchers have developed a way to tailor therapies to combat the specific inappropriate responses of autoimmune diseases in mice. The researchers also have shown...

Propolis has stronger effects against IL-1 beta in cartilage than indomethacin.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- Propolis and its active principle caffeic acid phenethyl ester have stronger effects against interleukin-1beta in cartilage than indomethacin. According to a study from Italy, "Propolis, a natural...

Resistance may occur in bacteria if innate antibiotic proteins are used.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- There may be a risk involved in use of innate antibiotic molecules against bacterial infection. According to a study from Canada, "A remarkable range of novel antibiotics is attracting increasing...

Autoreactive B lymphocytes may be removable by recombinant fusion proteins.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- Autoantigen Fcgamma1 fusion proteins appear to selectively eliminate autoreactive B lymphocytes. According to a study from Germany, "Antigen-specific B cells are key players in many autoimmune...

Anti-gp41 antibody and interleukin-16 have synergistic anti-HIV effects.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- The cytokine interleukin (IL)-16 and an antibody targeting the HIV gp41 protein have synergistic antiviral effects. "HIV-1 replication is inhibited in T cells transfected with an anti-gp41 single...

IVIG is immunomodulatory, anti-inflammatory, and provides passive immunization.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- Intravenous immunoglobulin acts as an immunomodulatory, anti-inflammatory, and passive immunization providing therapeutic agent. "Intravenous immunoglobulin (IVIG) preparations are fractionated...

Treatment passes Phase II clinical trials.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- About 10% of people with psoriasis develop chronic inflammation of the joints called psoriatic arthritis. In clinical trials testing a drug based on the discovery of Professor David Wallach of the...

Polysaccharide extracts from different algae produce different immune effects.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- Polysaccharide extracts from different microalgae produce differing immune effects, but both act as anti-inflammatory agents. According to published research from Spain, "Crude polysaccharide...

Mast cell product-antagonizing is short-term treatment, long-term solutions needed.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- Allergic rhinitis treatment has been short term, based on mast cell product reduction; soon longterm therapy may be possible. "Mast cells not only function as effector cells, but also influence...

Rhinitis immunotherapy using specific subcutaneous allergen is better than drugs.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- Allergic rhinitis may be treated and reduced by subcutaneous allergen specific immunotherapy, instead of drugs. According to recent research from Denmark, "Allergen-specific immunotherapy in the...

Latex allergy may create cross-reactive fruit allergies; kiwi is highest risk.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- Patients with allergy to latex should be warned of possible crossreactivity with some fruits; kiwi, banana, avocado being the greatest risk. "Since the first case reported in 1927, latex allergy has...

Immature dendritic cells have a receptor for human mannan-binding lectin.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- Monocytes and dendritic cells produce mannan-binding lectins, and immature dendritic cells have an upregulated receptor for some. "Mannan-binding lectin (MBL) is a collectin synthesized by the...

Gallerimycin, a moth-derived antifungal peptide, isn't active against yeast.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- A new antifungal discovered in wax moth, gallerimycin, is not active against yeast. According to published research from Germany, "A novel defensin-like peptide was identified in the greater wax...

TSLC1 gene in human lung cancer is probably a cell adhesion molecule.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- The mouse ortholog of TSLC1, a tumor suppressor gene in human lung cancer, is found to be a cell adhesion molecule that may be expressed more to slow metastasis. According to recent research from...

Airway epithelium is in constant repair; allergens create cyclic Th2 response.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- Asthmatic airway epithelium is in constant repair mode, and a cycle of Th2 responses due to contact with environmental allergens. "Epithelial cells in the airway wall actively interact with...

Biomedical engineer receives $1.8 million grant to study lung damage.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- University of California Irvine biomedical engineer Steven C. George, who is one of the first U.S. scientists to create three-dimensional living lung tissue, has received a $1.8 million grant from the...

Disodium chromoglycate doesn't help kids with asthma.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- After 35 years of use, advice has changed and doctors are no longer recommended to prescribe disodium cromogycate (DSCG) to children with asthma. New research, just published in The Cochrane...

Food allergy may be a source to consider for asthma of unknown origin.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- Although rare, foods may be a source to investigate in asthma of unknown origin; blinded food challenges can prove it. According to a study from the United States, "Food allergy may present with a...

Patent awarded for therapeutic uses of interleukin-9 receptor protein.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- Genaera Corp. (GENR) announced issuance by the United States Patent and Trademark Office of patent number 6,602,850 covering the use of certain soluble human interleukin-9 (IL-9) receptor protein...

Revotar reports positive results with small molecule selectin antagonist.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- Encysive Pharmaceuticals (ENCY) announced its majority-owned German affiliate, Revotar Biopharmaceuticals, AG, reported positive results with bimosiamose in a 12-patient, double-blind, cross-over,...

Study links preschool snoring, asthma, and nighttime cough.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- Preschool-age children who regularly snore have a higher prevalence of asthma and nighttime cough than children who do not snore, says a new study. The study found that preschool children who snored...

Study of glucocorticoid-receptor interactions may lead to new anti-asthma agents.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- Studies on the binding of glucocorticoids to the receptor and subsequent activity may lead to new and better anti-asthma agents. "Glucocorticoids are widely used to treat inflammatory and immune...

Nramp gene determines efficacy of mycobacteria-based asthma treatment.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- The human Nramp gene determines the efficacy of mycobacteria-based asthma treatment. "Genes controlling antibacterial resistance may be important in the hygiene hypothesis, which states that lack of...

Array analysis of autoimmune disease leads to vaccine development.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- Researchers have developed protein arrays that could be used to diagnose autoimmune diseases, such as multiple sclerosis, earlier than is currently possible. The approach, described in the...

Some MG seronegative patients may be MuSK antibody positive.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- MG seronegative patients may be atypical and some can be identified by MuSK antibody positivity. "Serum antibodies to muscle specific receptor tyrosine kinase (MuSK) were detected in 12/32 patients...

Systemic lupus erythematosus is more prevalent than was previously thought.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- Lupus is more prevalent than previously thought, but many testing positive for the disease have milder cases. "Systemic lupus erythematosus (SLE) is the most diverse of the autoimmune diseases...

Efficient Vav3 translocation to B cell membrane rafts requires Grb2 and BLNK.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- Vav3 requires Grb2 and BLNK to translocate efficiently to membrane rafts. According to published research from Japan, "Despite the importance of the Vav family proteins for B cell receptor (BCR)...

Breast cancer, metastasis, growth reduced with i.v. bee venom therapy in murine model.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- In a mouse breast cancer model, intravenous but not intradermal bee venom reduced metastasis to lung. According to published research from Croatia, "The possible tumor growth-inhibiting and...

Symptoms, cirrhosis disease progression are known; cause and cure remain elusive.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- Some of the symptoms and disease progression are known for primary biliary cirrhosis, but the cause and cure, other than liver transplant, remain elusive. According to published research from the...

Antithymocyte globulin lowers GVHD, worsens T-cell deficiency.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- Antithymocyte globulin therapy in bone marrow transplant recipients lowers incidence of graft versus host disease, but extends the time of severe T cell deficiency. "The effect of antithymocyte...

Seropositive schizophrenic patients respond to cerebrospinal fluid filtration.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- Therapy resistant schizophrenia or affective spectrum psychosis patients positive for Borna disease virus antibodies do respond to cerebrospinal fluid filtration. "According to previous...

Cytokine imbalances mark the pathogenesis of chronic lymphocytic leukemia.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- Cytokine imbalances mark the pathogenesis of chronic lymphocytic leukemia. According to published research from Poland, "the serum concentration of two proangiogenic cytokines: basic fibroblast...

Diabody-based gene therapy represents a new strategy for cancer therapy.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- Diabody-based gene therapy represents a new strategy for cancer therapy. "Infiltrating T cells are found in many malignancies, but they appear to be mostly anergic and do not attack the tumor,...

Antibody fragments fused to IL-12 and to TNF-alpha exert anti-tumor effect.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- The combination of a tumor-targeting antibody fragment fused to interleukin 12 and to tumor necrosis factor alpha exerts a synergistic effect against tumors. "The potent antitumor activity of...

Current developments in cancer vaccines and cellular immunotherapy reviewed.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- Investigators have published a review on the current developments in cancer vaccines and cellular immunotherapy. "This article reviews the immunologic basis of clinical trials that test means of...

IL-6 fused to antibody increases immune response against ovarian cancer.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- Interleukin-6 fused to an anti-idiotype antibody in a vaccine increases the specific humoral immune response against CA125+ (MUC-16) ovarian cancer "Anti-idiotypic (Id) monoclonal antibodies can...

MUC1-derived glycopeptides are strong antigens for breast cancer vaccines.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- MUC1-derived glycopeptide libraries with improved MHC anchors are strong antigens and prime mouse T cells for proliferative responses to lysates of human breast cancer tissue According to recent...

Peptide vaccine with adjuvant and CTLA-4 blockade elicits antitumor response.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- A protective antitumor immune response was elicited by cytotoxic T lymphocyte epitope peptide vaccination combined with CpG-oligodeoxynucleotide adjuvant and a CTLA-4 blockade. "Although peptide...

Molecule subdues inflammatory response.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- Uncontrolled inflammation is a chief cause of morbidity and mortality. In a new study, scientists show that a natural molecule in our body known as SIGIRR regulates inflammation by dampening signals...

Papillomavirus E7 protein blocks pCAF's acetyltransferase, a p53 coactivator.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- Papillomavirus E7 proteins react with pCAF's acetyltransferase domain, normally a coactivator of the p53 transcription factor. According to a study from Canada, "Most cervical carcinomas express...

LPS polysaccharide from strain PCM 1531 isn't same as others in group O6.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- LPS polysaccharide in Citrobacter braakii PCM 1531 is not shared by the rest of serogroup O6. According to a study from Poland, "The O-specific polysaccharide of Citrobacter braakii PCM 1531...

Research alliance centers on monoclonal antibody for inflammatory disease.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- Abbott Laboratories and LigoCyte Pharmaceuticals, Inc., announced a research collaboration on an anti-inflammatory monoclonal antibody for the treatment of inflammatory diseases. The collaboration...

Cordyceps pruinosa extract inhibits NF-kappaB gene expression.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- Extracts from the medicinal fungus Cordyceps pruinosa reduce inflammation by disrupting NF-kappaB gene expression. C. pruinosa "has been used in traditional folk medicine to treat numerous...

Anti-TNF-antibody therapy shows same results in IL-10 knockout mouse as humans.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- Anti-TNF-antibody therapy confirms IL-10 knockout mouse response is the same as in humans; it can be used to investigate other therapeutic approaches. According to recent research published in the...

Protein inhibitor of activated STAT3 and androgen receptor compete for STAT3.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- Androgen receptor and protein inhibitor of activated STAT3 (PIAS3) compete for regulation of STAT3 and thus affect the IL-6 family of cytokines. "STAT3 mainly acts as a signal transducer of IL-6...

Immature dendritic cells are largely unaffected by apoptotic T cells.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- Apoptotic T cells have no major effect on immature dendritic cells, nor are they phagocytized by them; also, this does not induce them into a tolerogenic mode. "Dendritic cells (DCs) play an...

EGF receptor may play critical role in suppressing keratinocyte inflammation.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- EGFR appears to play a critical role in suppressing keratinocyte inflammation; in this case a mouse model of contact hypersensitivity was used, but it may affect all forms of skin inflammation and...

Trio of AFP, PIVKAII, GGTII increases accuracy of liver cancer diagnosis.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- Diagnosis of hepatocellular carcinoma is easier using not only alpha-fetoprotein, but protein induced by vitamin K absence and gamma glutamyl transferase as markers, too. "Serum protein induced by...

Pediatric Lyme arthritis can be diagnosed using a recombinant IR6 assay.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- Pediatric cases of Lyme arthritis can be diagnosed with one or several antigens, of which IR6 appears to be the best. "The performance of ELISAs with the recombinant antigens decorin-binding...

Drugs must target particular compartment where protein they act upon is located.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- Drugs must be designed to reach the particular compartment in which the protein they act upon is, within the cell. "One of the more overlooked aspects of drug action and delivery is the...

The herbicide simazine may cause suppression of many immune system functions.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- The herbicide simazine was found to increase adrenal weight and suppress many parts of the immune system in mice. According to published research from South Korea, "Simazine, a triazine herbicide,...

Risk of human ehrlichiosis in Germany present despite no clinical cases.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- The risk of human ehrlichiosis is there in Germany, despite no clinical cases, as Anaplasma phagocytophilum is found present in ticks and a sick horse. "Based on seroprevalence studies and tick...

Inflammatory pseudotumor due to clonal EBV-infected cells can occur in spleen.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- Inflammatory pseudotumor due to clonal EBV-infected cells can occur in the spleen. According to a study from the United States, "We report a case of an inflammatory pseudotumor (IPT) of the spleen...

The StcE gene was probably acquired by E. coli O157:H7 via plasmid.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- StcE, a metalloprotease, was probably acquired by E. coli O157:H7 via plasmid. "Escherichia coli O157:H7 is a source of foodborne illness; causing diarrhea, hemorrhagic colitis, and hemolytic-uremic...

An MHC-like region of 19 genes is conserved between humans and fruit flies.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- A region of 19 MHC and related genes is conserved as a block between humans and fruit flies. According to recent research from France, "Identification of conserved regions between the genomes of...

Midaortic syndrome and cardiomyopathy can give nonimmune fetal hydrops.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- Midaortic syndrome and cardiomyopathy can give nonimmune fetal hydrops. According to recent research published in the journal Pediatrics, "Nonimmune hydrops fetalis is the final common pathway of...

Company provides second quarter update, reports on CCR2 receptor antagonist program.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- Incyte Corp. (INCY) announced its second quarter financial results. "The second quarter has been productive and reflects our commitment to building our product pipeline, reducing expenses, and...

Company receives extension of waivers from EPIL noteholders.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- Elan Corp., plc, (ELN) announced that it has sought and received additional agreements from a majority of the holders of the guaranteed notes issued by Elan's qualifying special purpose entities, Elan...

Immunology company reports financial results, discusses Aventis collaboration.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- ImmunoGen, Inc., (IMGN) announced financial results for the 3- and 12-month periods ended June 30, 2003. For the 3-month period, the company reported a net loss of $6.9 million, or $0.17 per basic...

Shark cartilage has proteoglycans that stimulate macrophage and B, not T cells.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- Aqueous shark cartilage extract comprised of proteoglycans has B cell and macrophage, but not T cell stimulating properties. "Extracts from shark cartilage exhibiting powerful immunostimulating...

Pediatric hypersensitivity requires full elimination of the suspected food.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- Elimination of a particular food from the diet due to allergy or suspected allergy involves extensive education. According to a study from the United States, "the diagnosis and management of food...

Recent recommendations for food allergen avoidance in children are reconciled.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- A comprehensive view of recent recommendations from various bodies regarding food allergies in children reconciles all experts' suggestions. "Food allergy afflicts an increasing number of infants...

Treatment for peanut-induced anaphylaxis may soon involve anti-IgE.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- For most food anaphylaxis, the cure still involves epinephrine; for peanut allergies there are some new solutions being developed that include use of anti-IgE antibodies. According to recent...

Vibrio vulnificus strains vary seasonally in the Galveston Bay estuary.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- Vibrio vulnificus strains vary seasonally in the Galveston Bay estuary, between two rDNA-typable isolates. According to a study from the United States, "The partial sequence (600 bp) containing the...

Human Genome Sciences announces license agreement.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- Human Genome Sciences, Inc., (HGSI) announced a license agreement with Genentech, Inc., (DNA). Under this agreement, Genentech has acquired exclusive, worldwide patent rights to develop and...

Influenza A recurrence in myocarditis may cause cardiogenic shock.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- Reinfection with influenza A following recovery from acute influenza A myocarditis may cause death. According to recent research published in the Circulation Journal, "A 75-year-old man recovered...

Markers of abacavir allergy versus influenza virus infection identified.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- Symptoms useful for distinguishing between influenza virus infection and allergic reactions to the anti-HIV drug abacavir have been identified. "Differentiation between abacavir hypersensitivity and...

Tat-expressing Sendai viral vector-booster does not increase protection.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- No significant enhancement of protection by Tat-expressing Sendai viral vector-booster occurred in a macaque AIDS model. According to a study from Japan, "We previously developed a...

Inducible costimulator ICOS is involved in T cell activation, IL-4 production.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- ICOS is involved in activation of T cells and regulation of IL-4 transcription. According to a study from the United States, "Helper T (Th) cell differentiation is accompanied by complex...

Novel suicide fusion genes stem T cell reactions after transplantation.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- Two novel suicide fusion genes stem T cell reactions after transplantation. "Donor lymphocyte infusions (DLI) following allogeneic stem cell transplantation are known to mediate...

The HSV ICP8 DNA-binding protein becomes altered upon viral replication setup.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- Specific antibodies can recognize the conformational changes that occur in HSV ICP8; the changes appear to occur during assembly of viral DNA replicative structures. According to a study from the...

Histamine receptors can bind many molecules, resulting in diverse actions.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- Histamine receptor research is revealing multiple functions, including neurological involvement. "Histamine and antihistamines are so deeply woven into the fabric of allergic diseases that it is...

Activation of central baroreceptor pathway sustained in hypertension.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- The activation of the central baroreceptor pathway is sustained in obesity hypertension. According to a study from the United States, "The major goal of this study was to determine whether there is...

Peptostreptococcus magnus protein L has immunoglobulin binding domains.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- Peptostreptococcus magnus protein L has kappa-chain immunoglobulin binding domains. According to recent research published in the journal Biochemical Society Transactions, "Protein L is a...

"Macrophageless" mice have near-normal wound healing.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- Surprisingly, mice with genetic mutations that prevent macrophage development have near-normal wound healing abilities. "Damage to neonatal and adult tissues always incites an influx of...

Chromatin antibodies associate with autoimmune hepatitis pathology.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- Chromatin antibodies associate with autoimmune hepatitis pathology. "Our aims were to determine the frequency and prognostic implications of antibodies to chromatin in autoimmune hepatitis. Three...

Inactivated parapoxvirus ovis protects against hepatitis and herpes viruses.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- Inactivated parapoxvirus ovis protects against hepatitis and herpes viruses. "It is known that some viruses are able to induce vigorous immune reactions. This study shows that inactivated...

Interleukin-21 gene therapy activates perforin-dependent tumor immunity.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- Interleukin-21 gene therapy activates perforin-dependent tumor immunity. According to recent research from the United States, "Interleukin (IL)-21 is a key factor in the transition between innate...

Patent granted for ISA247, a calcineurin inhibitor.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- Isotechnika, Inc., has received an issue notification from the United States Patent and Trademark Office regarding its immunosuppressive compound ISA247. This application has been issued United...

Shark cartilage protein stimulates antitumor immunity in murine models.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- Shark cartilage protein stimulates antitumor immunity in murine models. "Shark cartilage has proven to have some inhibitory effects on angiogenesis, metastasis, cell adhesion and proteolysis. In...

Bone marrow transplant has characteristic risks for pulmonary complications.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- Due to immunosuppression, there are predictable points at which there can be pulmonary complications following bone marrow transplant. "Pulmonary complications account for significant morbidity and...

Embryonal rhabdomyosarcoma can occur following liver transplant.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- Liver transplant recipients have a risk of embryonal rhabdomyosarcoma growth following transplant immunosuppression. "Although an increased incidence of de novo malignancies is reported in...

Mannose-binding lectin quantity, thus infection resistance, may be genetic.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- The amounts of mannose-binding lectin and the individual's ability to resist infections appear to be related to specific haplotypes. According to recent research published in the Journal of...

New patents granted on oral-dosed, broad-spectrum immune activators.
September 3, 2003... 2003 SEP 3 - (NewsRx.com & NewsRx.net) -- Hemispherx Biopharma, Inc., (HEB), a company involved in the experimental-stage development of immune based therapies primarily addressing the diseases of Chronic Fatigue Syndrome, HIV/AIDS, and HPV,...