Immunotherapy Weekly articles from September 1999

Immunotherapy Weekly archives from September 1999

BCG and IFN-(alpha) Have Synergistic Therapeutic Effect.
September 6, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- A combination of immunotherapeutic agents exhibits a synergistic effect in a murine model of bladder cancer. Y.H. Gan and colleagues from the National University of Singapore investigated...

CD154 Gene Transfer Inhibits Tumor Growth.
September 6, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- CD154 gene transfer into MC38 colon carcinoma cells inhibited tumor growth in vivo. In previous research, C. Esche and colleagues from the University of Pittsburgh, Pennsylvania, demonstrated...

Chemo-Immunotherapy Shows Promise for Colorectal Cancer.
September 6, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Repeated cycles of chemo-immunotherapy show promise for the treatment of unresectable metastases in colorectal cancer patients. G. Silecchia and colleagues from the University Roma Tor Vergata,...

Laser Immunotherapy Solutions Get Better and Better.
September 6, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Glycated chitosan is better than indocyanine green and water for monitoring laser immunotherapy. F. Xu and colleagues from the University of Virginia reported their experimental results of...

Three-Dimensional Study Investigates Tumor Pathogenesis.
September 6, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- A three-dimensional, in vitro study helps researchers understand tumor adhesion, penetration, and internalization. C. Durek and colleagues from the University of Lubeck, Germany, studied...

Behavioral Program Boosts Antibody for Cancer.
September 6, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Women with breast cancer who participated in a psychological intervention program showed lower levels of a stress hormone and higher levels of a antibody that fights breast tumors than did other...

T. cruzi Infects Human Dendritic Cells.
September 6, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Trypanosoma cruzi, the etiological agent of Chagas' disease, is able to infect human dendritic cells, researchers report. A hemoflagellate protozoan parasite, T. cruzi infects humans as well as...

Lengthened IFN Therapy Improves HBV Outcome.
September 6, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- An interferon course that is twice as long as standard therapy appears to offer significant advantages for the treatment of chronic hepatitis B. Researchers from the European Concerted Action on...

Model Identifies and Selects T-Cell Clones for Immunotherapy.
September 6, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- A recently described experimental model may be effective for identifying and selecting T-cell clones for immunotherapy to prevent or treat relapse following hematopoietic cell transplantation. ...

Double Transplant Frees Patient from Need for Immunosuppressive Drugs.
September 6, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- While organ transplants have been one of the great success stories of 20th century medicine, one of the downsides of the lifesaving procedures has been the requirement that organ recipients take...

Large Doses of Vitamin C Endorsed by Researcher.
September 6, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Large doses of vitamin C may boost the immune system and help the human body's defense mechanisms ward off diseases and health problems, including heart attacks and cancer, according to research at...

Fibrocytes: Blood-Borne, Fibroblast-Like Cells with Potent Antigen Presentation Properties.
September 6, 1999... Cancer Immunotherapy "Fibrocytes: Blood-Borne, Fibroblast-Like Cells with Potent Antigen Presentation Properties." R. Bucalla. The Picower Institute for Medical Research, 350 Community Drive, Manhasset, New York 10030, USA. (CW...

Development of a Vaccine Against Colon Carcinoma Based on Cytokine-Transduced Autologous Tumor Cells.
September 6, 1999... Cancer Vaccines "Development of a Vaccine Against Colon Carcinoma Based on Cytokine-Transduced Autologous Tumor Cells." K.L. Glazenburg, S. Withoff, M.M.J. Kraak, M.L. van Veen, E.G.E. de Vries, J.C. Wilschut and T. Daemen. University of...

Evaluation of Immunomodulatory Property of Nyctanthes arbor-tristis.
September 6, 1999... Drug Development "Evaluation of Immunomodulatory Property of Nyctanthes arbor-tristis." A. Bhatia and J. Kaur. Department of Biotechnology, Punjabi University, Patiala 147002, Punjab, India. (CW HENDERSON PUBLISHER www.newsfile.com) --...

Quantitative Normalization of CD4 Cells in Blood and Lymph Node of HIV Infected Adults at Early Stage of Chronic Infection and No Previous Antiretroviral Therapy Treated with Ziagen Plus Amprenavir.
September 6, 1999... Drug Development (Antiviral) "Quantitative Normalization of CD4 Cells in Blood and Lymph Node of HIV Infected Adults at Early Stage of Chronic Infection and No Previous Antiretroviral Therapy Treated with Ziagen Plus Amprenavir." G.P....

Interferon-gamma- and Interleukin-4-Targeted Gene Therapy for Atopic Allergic Disease.
September 6, 1999... Allergy Medicine Wang, K.W.; Kim, T.S.; Kim, K.M. "Interferon-gamma- and Interleukin-4-Targeted Gene Therapy for Atopic Allergic Disease." Immunology, July 1999;97(3):462-465. (CW HENDERSON PUBLISHER www.newsfile.com) -- According to...

Immunotherapy With Effector Cells and IL-2 of Lymph Node Metastases of Human Squamous-Cell Carcinoma of the Head and Neck Established in Nude Mice.
September 6, 1999... Cancer Immunotherapy Chikamatsu, K.; Reichert, T.E.; Kashii, Y.; Saito, T.; Kawashiri, S.; Yamamoto, E.; Whiteside, T.L. "Immunotherapy With Effector Cells and IL-2 of Lymph Node Metastases of Human Squamous-Cell Carcinoma of the Head and...

Application of oligo-(14-amino-3,6,9,12-tetraoxatetradecanoic acid) Lipid Conjugates as Steric Barrier Molecules in Liposomal Formulations.
September 6, 1999... Liposomal Delivery Ansell, S.M.; Kojic, L.D.; Hankins, J.S.; Sekirov, L.; Boey, A.; Lee, D.K.; Bennett, A.R.; Klimuk, S.K.; Harasym, T.O.; Dossantos, N.; Semple, S.C. "Application of oligo-(14-amino-3,6,9,12-tetraoxatetradecanoic acid)...

Design of Immuno-Enzymosomes With Maximum Enzyme Targeting Capability: Effect of the Enzyme Density on the Enzyme Targeting Capability and Cell Binding Properties.
September 6, 1999... Liposomal Delivery Fonseca, M.J.; Haisma, H.J.; Klaasen, S.; Vingerhoeds, M.H.; Storm, G. "Design of Immuno-Enzymosomes With Maximum Enzyme Targeting Capability: Effect of the Enzyme Density on the Enzyme Targeting Capability and Cell...

Elastase Activated Liposomal Delivery to Nucleated Cells.
September 6, 1999... Liposomal Delivery Pak, C.C.; Erukulla, R.K.; Ahl, P.L.; Janoff, A.S.; Meers, P. "Elastase Activated Liposomal Delivery to Nucleated Cells." Biochimica Et Biophysica Acta - Biomembranes, July 15, 1999;1419(2):111-126. (CW HENDERSON...

Targeting Human Prostatic Carcinoma Through Basic Fibroblast Growth Factor Receptors in an Animal Model: Characterizing and Circumventing Mechanisms of Tumor Resistance.
September 6, 1999... Prostate Cancer Davol, P.A.; Frackelton, A.R. "Targeting Human Prostatic Carcinoma Through Basic Fibroblast Growth Factor Receptors in an Animal Model: Characterizing and Circumventing Mechanisms of Tumor Resistance." Prostate, August 1,...

Oral Ganciclovir Treatment in Chronic Hepatitis B Virus Infection: A Pilot Study.
September 6, 1999... Therapy (HBV) Hadziyannis, S.J.; Manesis, E.G.; Papakonstantinou, A. "Oral Ganciclovir Treatment in Chronic Hepatitis B Virus Infection: A Pilot Study." Journal of Hepatology, August 1999;31(2):210-214. (CW HENDERSON PUBLISHER...

Daily Interferon Regimen for Chronic Hepatitis C - A Prospective Randomised Study.
September 6, 1999... Therapy (HCV) Bruno, R.; Debiaggi, M.; Sacchi, P.; Maffezzini, E.; Zara, F.; Brunetti, E.; Filice, C.; Patruno, S.F.A.; Filice, G. "Daily Interferon Regimen for Chronic Hepatitis C - A Prospective Randomised Study." Clinical Drug...

Calcium Mobilization Generates DCs for Immunotherapy of CML.(Statistical Data Included)
September 13, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Calcium signaling can cause chronic myelogenous leukemia (CML) myeloid progenitor cells to acquire dendritic cell (DC) characteristics with immunotherapeutic potential. Friederike H.C. Engels...

Oligodeoxynucleotides Show Promise as Adjuvants.(Statistical Data Included)
September 13, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Oligodeoxynucleotides containing CpG motifs strongly influence immune responses from allergic patients. B. Bohle and colleagues from the University of Vienna, Austria, investigated the effects...

Fusion Proteins Can Have Immunomodulating Effect.(Statistical Data Included)
September 13, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Fusion proteins can be used to convert B7-negative tumors into B7-positive tumors without gene transfer. P. Holliger and colleagues from the University Klin Koln, Germany, demonstrated that...

Activated Natural Killer Cells Exhibit Enhanced Lysis.(Statistical Data Included)
September 13, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Natural killer (NK) cells activated with interleukin (IL)-2 and IL-12 demonstrated enhanced lysis of tumor cells. C. Lehmann and colleagues from the University of Kiel, Germany, investigated the...

Immunoregulation of Sarcoid Granulomas with Somatostatin.(Statistical Data Included)
September 13, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Somatostatin analogs show potential immunomodulatory effects against sarcoidosis and other granulomatous diseases. A.M.C. Tenbokum and colleagues from Erasmus University, The Netherlands,...

Nasal Tolerance Induced by Antigen Therapy.(Statistical Data Included)
September 13, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Recombinant fragments of human nicotinic acetylcholine receptor (AcChoR) can be used to induce nasal tolerization against myasthenia gravis. D. Barchan and colleagues from the Weizmann Institute...

Posttransplant CTL Transfer Works for Solid Tumors.(Statistical Data Included)
September 13, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- It isn't supposed to work for solid organ recipients, but it does. The dramatic treatment of a dying patient for the first time shows adoptive immunotherapy is possible in organ transplant...

Tat Toxoid Immunogenic, Safe In Human Trials.(Statistical Data Included)
September 13, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- A new AIDS vaccine/treatment strategy is moving quickly through human trials. The immunogen is an inactivated form of the HIV Tat protein. It could be both a vaccine and a treatment for AIDS. ...

IL-12 and NK Cells Have Role in Effector Phase of GVHD.(Statistical Data Included)
September 13, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Interleukin-12 and natural killer cells have a role in the effector phase of murine syngeneic graft-versus-host disease, researchers indicate. Syngeneic graft-vs-host disease (SGVHD) is induced...

Normal IgG4 Has Two Different Antigen-Combining Sites.(Statistical Data Included)
September 13, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- IgG4 antibodies possess two different antigen-binding sites, according to a recent report. Unlike other immunoglobulin G (IgG) subclasses, IgG4 antibodies in plasma have been reported to be...

Human MBL Shown To Directly Neutralize Influenza A.(Statistical Data Included)
September 13, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Human manan-binding lectin may play a critical role in influenza A immunity through direct viral neutralization and inhibition of viral spread. Mannan-binding lectin (MBL) is a C-type serum...

Inflammatory Mechanism of Subacute Thyroiditis Studied.(Statistical Data Included)
September 13, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Recent findings help clarify the immunohistochemical expression of growth factors in subacute thyroiditis. The inflammatory-mechanistic basis of subacute thyroiditis remains unclear. S. Toda and...

Vaccine Trial Initiated in Lung Cancer Patients.(Statistical Data Included)
September 13, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- York Medical Inc., Mississauga, Ontario, Canada, has announced that the first patient has been enrolled in its pivotal clinical trial to evaluate its cancer vaccine in advanced lung cancer patients....

Four Genes Found that Could Prevent Lupus.(Statistical Data Included)
September 13, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- The recent discovery of four genes that can halt lupus, which affects about 1.5 million Americans, could lead to the development of preventive drugs. By studying mice biologically altered to have...

B7-2/GM-CSF Combination Immunogene Therapy for Gliomas: Preliminary Results from a Pilot Clinical Trial.(Statistical Data Included)
September 13, 1999... Cancer Immunotherapy "B7-2/GM-CSF Combination Immunogene Therapy for Gliomas: Preliminary Results from a Pilot Clinical Trial." I.F. Parney, L.-J. Chang, E. Solano, M.A. Farr-Jones, H. Vandenhoven, C. Hao, K. Kane, A. Gainer, R. Urtasun,...

Can DNA Immunization Against CD28 or CTLA-4 Prevent Rheumatic Disease in Rodent Models?(Statistical Data Included)
September 13, 1999... DNA Vaccines (Arthritis) "Can DNA Immunization Against CD28 or CTLA-4 Prevent Rheumatic Disease in Rodent Models?" Nadia Terrazzini, Michael Binks, Benny Chain and Torben Lund. Department of Immunology, University College London, United...

Construction of a DNA Vaccine Based on the fomA Gene from Fusobacterium nucleatum ATCC 10953.(Statistical Data Included)
September 13, 1999... DNA Vaccines (Periodontitis) "Construction of a DNA Vaccine Based on the fomA Gene from Fusobacterium nucleatum ATCC 10953." C.K. Skar, H. Steinmoen, I.P. Nunes, A. Nerland, A. Bolstad and V. Bakken. Department of Odontology - Oral...

Suppressive Versus Stimulatory Effects of Allergen/Cholera Toxoid (CTB) Conjugates Depending on the Nature of the Allergen in a Murine Model of Type I Allergy.(Statistical Data Included)
September 13, 1999... Autoimmune Disease Wiedermann, U.; Jahnschmid, B.; Lindblad, M.; Rask, C.; Holmgren, J.; Kraft, D.; Ebner, C. "Suppressive Versus Stimulatory Effects of Allergen/Cholera Toxoid (CTB) Conjugates Depending on the Nature of the Allergen in a...

CD3x Anti-Nitrophenyl Bispecific Diabodies: Universal Immunotherapeutic Tools for Retargeting T Cells to Tumors.(Statistical Data Included)
September 13, 1999... Cellular Immunotherapy Manzke, O.; Fitzgerald, K.J.; Holliger, P.; Klock, J.; Span, M.; Fleischmann, B.; Hescheler, J.; Liu, Q.H.; Johnson, K.S.; Diehl, V.; Hoogenboom, H.R.; Bohlen, H. "CD3x Anti-Nitrophenyl Bispecific Diabodies:...

Modulation of Immune Function by a Modified Bovine Whey Protein Concentrate.(Statistical Data Included)
September 13, 1999... Immunology Cross, M.L.; Gill, H.S. "Modulation of Immune Function by a Modified Bovine Whey Protein Concentrate." Immunology and Cell Biology, August 1999;77(4):345-350. (CW HENDERSON PUBLISHER www.newsfile.com) -- According to the...

Anticancer Effect of 9-nitrocamptothecin Liposome Aerosol on Human Cancer Xenografts in Nude Mice.(Statistical Data Included)
September 13, 1999... Liposomal Delivery Knight, V.; Koshkina, N.V.; Waldrep, J.C.; Giovanella, B.C.; Gilbert, B.E. "Anticancer Effect of 9-nitrocamptothecin Liposome Aerosol on Human Cancer Xenografts in Nude Mice." Cancer Chemotherapy and Pharmacology,...

Distribution of Camptothecin After Delivery as a Liposome Aerosol or Following Intramuscular Injection in Mice.(Statistical Data Included)
September 13, 1999... Liposomal Delivery Koshkina, N.V.; Gilbert, B.E.; Waldrep, J.C.; Seryshev, A.; Knight, V. "Distribution of Camptothecin After Delivery as a Liposome Aerosol or Following Intramuscular Injection in Mice." Cancer Chemotherapy and...

A Genetically Modified Recombinant Tumor Necrosis Factor-alpha Conjugated to the Distal Terminals of Liposomal Surface Grafted Polyethyleneglycol Chains.(Statistical Data Included)
September 13, 1999... Recombinant Cytokines Savva, M.; Duda, E.; Huang, L. "A Genetically Modified Recombinant Tumor Necrosis Factor-alpha Conjugated to the Distal Terminals of Liposomal Surface Grafted Polyethyleneglycol Chains." International Journal of...

Normal Dendritic Cell Function in HIV(+) Suggests Immunotherapy.
September 20, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Because dendritic cell (DC) function in HIV(+) individuals is normal, these cells could be used to boost patients' cellular immune responses, researchers suggest. C. Chougnet and colleagues from...

Therapy Successfully Targets Vasculature Endothelial Cells.
September 20, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- An immunotherapy for cancer that targets both the tumor vasculature and tumor cells has shown promising results in a murine model of human melanoma. Zhiwei Hu and colleagues from Yale University,...

Lipid-DNA Complexes Induce Potent Antitumor Activity.
September 20, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Intravenous (i.v.) administration of lipid-DNA complexes induces anticancer immunologic effects, a recent study finds. S.W. Dow and colleagues from the National Jewish Medical and Research...

Tumor-Targeted IL-2 Amplifies Immune Response.
September 20, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Booster vaccination with tumor-targeted interleukin-2 (IL-2) amplifies immune responses induced by prior gene therapy with single-chain IL-12. The induction, maintenance, and amplification of...

Co-Stimulatory Pathways Can Optimize Adoptive Immunotherapy.
September 20, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Co-stimulatory pathways can be combined to optimize adoptive anticancer immunotherapy. D. Schmitter and colleagues from the University of Zurich Hospital, Switzerland, investigated co-stimulatory...

HLA Class I Allele Loss in Melanoma Cells Is Detrimental.
September 20, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Human leukocyte antigen (HLA) class I allele loss allows melanoma cells to escape immune recognition. Z.G. Wang and colleagues from the Roswell Park Cancer Institute, Buffalo, New York,...

Immunogene Therapy Prolonged Survival in Murine Cancer Model.
September 20, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Liposome-mediated transfer of a combination of interleukin-2 (IL-2) and IL-6 genes prolonged survival in tumor-bearing mice. X. Cao and colleagues from the Second Military Medical University,...

Mucosal Cytokine Treatment Has Antiviral/Antitumor Activity.
September 20, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- A report from France offers further evidence that mucosal cytokine therapy elicits both antiviral and antitumor response. Researcher M.G. Tovey and colleagues from Villejuif's Cancer Research...

Endometriosis: An Allergic Condition?
September 20, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Are endometriosis and allergies related? It's possible, suggest researchers. Jeffrey A. Morrison, MD, and John Sullivan, MD, both of Harrisburg, Pennsylvania, described a novel treatment - an...

Passive Immunization Protects Against P. aeruginosa.
September 20, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Passive immunization with antiserum against heat-killed bacteria and exotoxin A protects against gut-derived sepsis caused by Pseudomonas aeruginosa in a murine model. T. Matsumoto and...

Oral IFN-(alpha) Action Explored.
September 20, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- The mechanism of action for oral interferon alpha has been evaluated by researchers at North Carolina State University. It is now well accepted that type 1 interferons (IFNs), IFN-alpha and...

Promising Cancer Therapy Improved with Modified Chelate Complex.
September 20, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Radioimmunotherapy of cancer can be improved with the modified chelate, DO3A1Pr, a study suggests. Y.H. Jang and colleagues from CALTECH, Pasadena, California, investigated improvements for a...

Anti-CD154 Aids Islet Engraftment and Survival in Rhesus Monkeys.
September 20, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Long-term anti-CD154 treatment may support islet engraftment and long-term survival, according to animal study findings. Reported effects of anti-CD154 treatment on autoimmunity, alloreactivity,...

Herbal Medicine Shows Anti-HBV Synergy with Vaccine.
September 20, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- An herbal medicine known as sho-saiko-to may have a synergistic effect with vaccine therapy in the treatment of hepatitis B virus. A traditional herbal medicine, sho-saiko-to (TJ-9) improves...

Transcription Factors Interaction Affects Stem Cell Commitment.
September 20, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- The interactions between PU.1 and GATA proteins may affect stem cell lineage decisions, recent findings suggest. The process through which multipotential hematopoietic cells commit to distinct...

Oral IFN Effective Against CMV.
September 20, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Low-dose, oral interferon may be a valuable tool in the treatment of cytomegalovirus infections. Oral administration of type 1 interferons (IFNs; murine IFN-alpha and IFN-beta) reduces early...

IFN Useful in HCV with Mixed Cryoglobulinemia.
September 20, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Either interferon monotherapy or interferon with ribavirin is appropriate therapy for hepatitis C virus-associated symptomatic mixed cryoglobulinemia. Hepatitis C virus (HCV) infection has been...

Technique Builds Microscopic Medical Devices for Transplants.
September 20, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- The same technology that creates computer microchips may one day help treat diseases such as diabetes, according to an Ohio State University researcher. Mauro Ferrari, Ohio State, has devised a...

Immunotherapy Trial Initiation Announced.
September 20, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Genzyme Molecular Oncology, Framingham, Massachusetts, announced the initiation of a breast cancer vaccine Phase I clinical trial sponsored by investigator David Avigan, MD, of Beth Israel Deaconess...

HIV Drug Granted Expanded Access in France.
September 20, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Chiron Corp., Amsterdam, The Netherlands, announced that the French Ministry of Health (AFSSAPS) has granted an Authorization for Temporary Use (ATU) of Macrolin IL-2 for the treatment of people with...

Vaccination Centers Established in 13 Ukraine Cities.
September 20, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- American Medical Centers, a subsidiary of First Medical Group, Stamford, Connecticut, USA, announced in conjunction with the Ukraine Ministry of Health that it plans to establish 29 vaccination...

Cuba Upbeat on Vaccine Deal.
September 20, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Cuba's deal with pharmaceutical company SmithKline Beecham to market the island's unique meningitis B vaccine could protect millions round the world as well as prove a useful business prospect,...

Remune in Children Suggests Sustained Reduction of Viral Load.
September 20, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- The Immune Response Corp. announced that data from two U.S. Remune trials appeared in the September 1999 issue of the Journal of Infectious Diseases (1999;180(3)). The preliminary results of a...

Immune Tolerance Induction in Hemophilia A Patients with FVIII Inhibitors: Costly Can Be Cheaper.
September 20, 1999... Hemophilia Therapy (Economics) "Immune Tolerance Induction in Hemophilia A Patients with FVIII Inhibitors: Costly Can Be Cheaper." Alan B. Colowick, Rhonda L. Bohn, Bruce M. Ewenstein and Jerry Avorn. Harvard Medical School and Brigham and...

A Mechanism Underlying the Effect of IFN- on BCG for Induction of Enhanced T-Helper-Type-1 (Th1) Immune Responses.
September 20, 1999... Cancer Immunotherapy "A Mechanism Underlying the Effect of IFN- on BCG for Induction of Enhanced T-Helper-Type-1 (Th1) Immune Responses." Y. Luo, X. Chen, W.C. De Wolf and M.A. O'Donnell. Boston, Massachusetts, USA. (CW HENDERSON...

Identification of Class II-Restricted Melanoma Antigen in a Long-Lived Patient with Melanoma: Implication in Terms of Vaccine Strategies.
September 20, 1999... Cancer Vaccines "Identification of Class II-Restricted Melanoma Antigen in a Long-Lived Patient with Melanoma: Implication in Terms of Vaccine Strategies." H. Zarour, W. Storkus and J. Kirkwood. Melanoma Center, University of Pittsburgh...

Human Immunodeficiency Virus Infected Cells Increase in Skin After Low Dose Ultraviolet B Treatment and Negatively Correlate with Peripheral Load.
September 20, 1999... Phototherapy (HIV) "Human Immunodeficiency Virus Infected Cells Increase in Skin After Low Dose Ultraviolet B Treatment and Negatively Correlate with Peripheral Load." J. Breuer-McHam, D.E. Lewis and M. Duvic. University Texas Medical...

Long-Term Clinical Efficacy of Grass-Pollen Immunotherapy.
September 20, 1999... Allergy Medicine Durham, S.R.; Walker, S.M.; Varga, E.M.; Jacobson, M.R.; Obrien, F.; Noble, W.; Till, S.J.; Hamid, Q.A.; Nouriaria, K.T. "Long-Term Clinical Efficacy of Grass-Pollen Immunotherapy." New England Journal of Medicine, August...

Molecular Epidemiology of Plasmodium falciparum Antifolate Resistance in Vietnam: Genotyping for Resistance Variants of Dihydropteroate Synthase and Dihydrofolate Reductase.
September 20, 1999... Malaria (Drug Resistance) Masimirembwa, C.M.; Phuongdung, N.; Phuc, B.Q.; Ducdao, L.; Sy, N.D.; Skold, O.; Swedberg, G. "Molecular Epidemiology of Plasmodium falciparum Antifolate Resistance in Vietnam: Genotyping for Resistance Variants...

Methods to Avoid Adverse Effect of Circulating Antigen on Biodistribution of I-125-Labeled AntiTac dsFv: Preinjection of Intact Antibody Versus Clearance of Antigen With Avidin-Biotin System.
September 20, 1999... Radiolabeled Antibodies Kobayashi, H.; Sun, B.F.; Yoo, T.M.; Le, N.; Kim, M.K.; Paik, C.H.; Pastan, I.; Waldmann, T.A.; Carrasquillo, J.A. "Methods to Avoid Adverse Effect of Circulating Antigen on Biodistribution of I-125-Labeled AntiTac...

Retreatment With Higher Dose Interferon alpha in Children With Chronic Hepatitis B Infection.
September 20, 1999... Therapy (HBV) Ozen, H.; Kocak, N.; Yuce, A.; Gurakan, F. "Retreatment With Higher Dose Interferon alpha in Children With Chronic Hepatitis B Infection." Pediatric Infectious Disease Journal, August 1999;18(8):694-697. (CW HENDERSON...

Interferon alpha-2B and Ribavirin in Combination for Patients With Chronic Hepatitis C Who Failed to Respond to, or Relapsed After, Interferon alpha Therapy: A Randomized Trial.
September 20, 1999... Therapy (HCV) Barbaro, G.; Dilorenzo, G.; Belloni, G.; Ferrari, L.; Paiano, A.; Delpoggio, P.; Bacca, D.; Fruttaldo, L.; Mongio, F.; Francavilla, R.; Scotto, G.; Grisorio, B.; Calleri, G.; Annese, M.; Barelli, A.; Rocchetto, P.; Rizzo, G.;...

Outcome of Multi-Drug-Resistant Tuberculosis in France - A Nationwide Case-Control Study.
September 20, 1999... Tuberculosis (Drug Resistance) Flamentsaillour, M.; Robert, J.; Jarlier, V.; Grosset, J. "Outcome of Multi-Drug-Resistant Tuberculosis in France - A Nationwide Case-Control Study." American Journal of Respiratory and Critical Care...

Clinical Trial Studies Nicotinamide for Diabetes.
September 27, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Nicotinamide (NA) can be beneficial to patients with recent-onset Type 1 diabetes, a recent clinical trial shows. N. Visalli and colleagues from the University Campus of Biomedicine, Rome,...

T-Cell Responses to Isoallergens Differ Among Patients.(immune response variation research)
September 27, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Variations in immune responses suggest that allergy patients recognize isoallergens differently. P.A. Wurtzen and colleagues from the University of Copenhagen, Denmark, evaluated patient...

Bispecific Antibodies Are Efficient Cancer Cell Killers.
September 27, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- T cells activated by bispecific antibodies elicit excellent antitumor activity in vitro. R. Zeidler and colleagues from the University of Munich, Germany, investigated the immunomodulating...

Characterization of T-Cell Clonotypes May Facilitate Immunotherapy.
September 27, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Increased understanding of T-cell clonotypes may help researchers develop anticancer strategies. K. Hayashi and colleagues from the St. Marianna University, Japan, sought to determine whether...

Polyclonal Immunoglobulin Successful Against Burn Wound Infections.
September 27, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Passive local immunotherapy (PLI) is safe and efficacious against burn wound infections. Infection is the leading cause of morbidity and mortality in severe burn wound patients. Often treatment...