Immunotherapy Weekly articles from October 2003

Immunotherapy Weekly archives from October 2003

CD44 mediates CCL5-induced cell activation and HIV infectivity enhancement.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- CD44 mediates CCL5-induced cell activation and enhancement of HIV infectivity. "The CC-chemokine RANTES (regulated on activation normal T-cell expressed and secreted; CCL5) transduces multiple...

Proteasome dysfunction in cytotoxicity mediated by anti-Ras antibodies.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- Scientists have found evidence that proteasome dysfunction in cytotoxicity is mediated by anti-Ras intracellular antibodies. According to published research from Italy, "Anti-Ras intracellular...

CD8 T, CD16 NK have different telomere shortening rates, telomerase activity.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- Aging based on telomere length and telomerase activity are different in CD8 T and CD16 NK cells; NK have telomerase activity and delayed senescence. "Telomeres are specialized structures located at...

Patients cautioned about melatonin.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- People with asthma should consider limiting the use of melatonin as a sleep aid, according to researchers at National Jewish Medical and Research Center. Pulmonologist Rand Sutherland, MD, MPH, and...

Atherosclerosis patients have CMV infection in vessel walls.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- Atherosclerotic lesions have human cytomegalovirus infection in the vessel walls; may be a site of latency. According to recent research published in the journal Molecular and Cellular...

Gemifloxacin is active against Neisseria gonorrhoeae with gyrA mutation.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- Gemifloxacin is active against Neisseria gonorrhoeae, including strains with gyrA mutations. "The MIC of gemifloxacin and 5 other quinolones was tested against 31 clinical isolates of Neisseria...

Biopharma inks agreement with Guangdong Medicine Group Corp.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- Hemispherx Biopharma, Inc., (HEB) announced that it has signed an agreement with Guangdong Medicine Group Corp. to organize clinical trials, marketing, sales, and distribution for both of its lead...

DHHS panel recommends Kaletra as part of protease inhibitor-based regimen.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- A panel convened by the U.S. Department of Health and Human Services (DHHS) has recommended Kaletra (lopinavir/ritonavir), in combination with zidovudine or stavudine plus lamivudine, as a preferred...

Salbutamol use may increase eosinophil CXCL8 production, asthmatic response.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- Regular salbutamol use may make eosinophil response to allergen stronger, increase airway inflammation via CXCL8/IL-8 increases in asthmatics. "Regular salbutamol use can exacerbate allergen-induced...

Restraint stress modulates regulation of inflammation and immunity.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- Acute restraint stress in allergic contact dermatitis modulates regulation of sensitizer-induced inflammation and immunity. "Previously, we demonstrated that restraint stress applied before...

Hepcidin is critical for iron transport, macrophage iron collection.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- Hepcidin is critical for iron transport, macrophage iron collection; lack of it can produce hemochromatosis. According to recent research published in the journal Blood, "Human hepcidin, a 25-amino...

Polymer-coated stents offer a way to delivery gene therapy to immune cells.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- Polymer-coated stents offer a way to delivery gene therapy to immune cells. According to a study from the United States, "metallic stents coated with a polyurethane emulsion containing plasmid DNA...

Ofloxacin receives FDA approval.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- Ranbaxy Pharmaceuticals Inc. (RPI), a wholly owned subsidiary of Ranbaxy Laboratories Limited (RLL), has received final approval from the U.S. Food and Drug Administration (FDA) to manufacture and...

Styryl-lactone goniothalamin induces leukemia cell caspase-dependent apoptosis.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- The styryl-lactone plant derivative goniothalamin induces leukemia cell mitochondrial, caspase-dependent apoptosis. According to recent research published in the journal Toxicology In Vitro,...

Human intestinal mucosa is rich in antibacterial, antifungal peptides.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- The human colonic mucosa is rich in peptides that have antibacterial and antifungal properties. According to recent research published in the journal Peptides, "Antimicrobial peptides and proteins...

Oral melatonin reduces proinflammatory response induced by amyloid-beta protein.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- Oral antioxidants melatonin and vitamins C and E reduced nitrites, lipoperoxides; but melatonin also reduced the proinflammatory response in an amyloid beta inflammation model. "To determine the...

Classical antisense PTOs used against key multimodal targets.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- Antisense Pharma focuses on the drug development for cancer treatment by combining precise selection of key cancer target molecules and DNA based phosphorothioate oligonucleotides (PTO). Positive data...

Cryptosporidiosis can produce arthritis, resolved by pathogen clearance.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- Cryptosporidiosis can produce reactive arthritis; pathogen clearance resolves rheumatic disease. "In contrast to arthritic disease caused by different bacterial agents, reactive arthritis due to...

Adults fail to follow flu vaccine guidelines.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- Adults with asthma are considered a high-risk group for developing complications after contracting the influenza virus, yet the majority of adults with asthma do not receive an annual influenza...

Asthma is exacerbated by eosinophilic pneumonia; corticosteroids may protect.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- Asthmatics who get idiopathic chronic eosinophilic pneumonia have worsened asthma but fewer pneumonia recurrences later, perhaps because they are given more corticosteroids. "Since idiopathic...

Children's school routines disrupted.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- According to a national sample of members surveyed from the National Association of School Nurses (NASN), asthma is more disruptive of school routines than any other chronic condition, has a significant...

HLA genotypes linked to Artemisia vulgaris allergy identified.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- HLA genotypes linked with allergic reactions to wormood have been identified. "Different human leukocyte antigen (HLA) class II alleles have been associated with the development of atopic asthma,"...

Preschool patients tested for pulmonary function.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- In one of the first pulmonary function studies to compare preschool children with asthma to healthy controls of similar age, French researchers, using tests that did not require active cooperation,...

BAFF regulates the number of B cells; high levels relate to autoimmune disease.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- BAFF is a member of TNF family that can alter the number of B cells; overexpression causes B-cell expansion and is related to autoimmune disease. According to recent research from Switzerland, "The...

Septicemia and bacterial DNA can cause autoantibodies and SLE-like symptoms.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- Septicemia and bacterial DNA can cause autoantibodies and some systemic lupus erythematosus-like symptoms. According to recent research from Japan, "Recent evidence has revealed that bacterial DNA...

HLA-A genes linked to pemphigus vulgaris in Jewish patients.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- Mutant HLA-A region genes have been linked to pemphigus vulgaris (PV) in Jewish patients. According to scientists in Israel, PV "is the most severe autoimmune blistering disorder of the skin that is...

Transcription coactivator OCA-B gene may be involved in B-cell expansion.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- The OCA-B gene is needed after B-cell receptor ligation and T helper costimulation, and appears to be involved in signaling B-cell expansion. "The tissue-specific transcriptional coactivator OCA-B...

Alpha-proteobacterium in an immunocompetent geriatric patient causes bacteremia.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- Bacteremia in an immunocompetent geriatric patient is caused by a new organism, an alpha-proteobacterium. According to recent research from North Ireland, "An 89-year-old male with pyrexia and...

Catecholamines enhance growth of E. coli but not some other bacteria.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- Catecholamines increase growth of E. coli but not some other bacterial species, including oral anaerobes. "The purpose of this study was to examine the effects of catecholamines on in vitro growth...

Trials for investigational pathogen inactivation system halted.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- Cerus Corporation (CERS) and subsidiaries of Baxter International, Inc., (BAX) announced that they are voluntarily halting phase III trials for their pathogen-inactivated red blood cell program. ...

Data from Theratope vaccine trial to be presented at breast cancer symposium.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- Biomira, Inc., (BIOM, BRA) announced that data from the final analysis of its Theratope vaccine phase III clinical trial in metastatic breast cancer will be presented at the 26th Annual San Antonio...

A dipstick assay works well to detect Brucella specific IgM serum antibodies.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- A dipstick assay for detection of Brucella IgM in serum works as well as an agglutination test, and not as well as culture in early brucellosis, but the culture assay works far better on patients sick...

Infection leading to autoimmune disease may also induce retinal vasculitis.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- Infection leading to autoimmmune disease may also induce retinal vasculitis. "Retinal vasculitis is a rare, but potentially blinding intraocular inflammatory condition with diverse etiology....

Par Pharmaceutical announces agreement with Bristol-Myers Squibb for Megace.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- Par Pharmaceutical, Inc., the principal subsidiary of Pharmaceutical Resources, Inc. (PRX), has entered into an agreement with Bristol-Myers Squibb Company (BMY) to license the Megace trade name to be...

Primary central nervous system lymphoma can have cryoglobulin deposits.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- Primary CNS lymphoma can have associated cryoglobulins too. "Primary central nervous system lymphomas (PCNSLs) represent malignant non-Hodgkin B-cell lymphomas confined to the central nervous...

Molecular fingerprinting and histology may show contradictory tissues of origin.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- Cancer samples must be examined for the site of origin of a tumor; molecular fingerprinting should reveal tissue origin, but histology results may not agree. According to published research from...

HSP10, HSP60 increase during progression of large bowel, uterine cancer.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- Heat shock proteins HSP10 and HSP60 become increasingly overexpressed as progression of large bowel cancer and uterine cancer occurs; could make good markers. "In the present study, we evaluated the...

Drug developed for rare disease may help millions more as cancer treatment.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- An antiangiogenesis drug developed at the University of Michigan (U-M) is showing promise in studies of three different disease families, including multiple forms of cancer. The drug,...

All-trans-retinoic acid improves effect of tumor vaccination.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- All-trans-retinoic acid eliminates immature myeloid cells from tumor-bearing mice and improves the effect of vaccination. "Tumor-induced immunosuppression is one of the crucial mechanisms of tumor...

Cancer vaccines present unique challenges.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- Cancer vaccines present unique challenges. According to a study from the United States, "Whether vaccines are designed to prepare the immune system for the encounter with a pathogen or with cancer,...

HPV-16-transformed cells expressing herpes thymidine kinase induce immunity.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- Immunization with live HPV-16-transformed mouse cells expressing the herpes simplex thymidine kinase and either granulocyte-macrophage colony stimulating factor (GM-CSF) or interleukin-2 (IL-2) had...

Immunization in tumor prevention reviewed.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- Researchers have published a review of immunization for tumor prevention in the journal International Immunopharmacology. According to a study from Italy, "Recent experimental data suggest that...

Progress in field of cancer vaccines reported.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- Progress in the field of cancer vaccines has been reported in a recent issue of the journal Cellular and Molecular Life Sciences. According to a study from France, "The observation that in some...

Level of disease activity, oral or vaginal location induce different enzymes.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- Candida albicans expresses different enzyme genes at different rates depending on location of infection and level of disease activity. "The in vivo expression of Candida albicans secreted aspartyl...

Two immune events occur involving dendritic cells and peptide:MHCII complexes.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- Two sets of immune events occur with dendritic cells and fluorescently tagged peptide binding to MHCII. "Peptide:MHC II complexes derived from a fluorescent antigen were detected in vivo to...

C-section has minor risk of maternal HSV-2 brain inflammation.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- Cesarean sections can have an HSV-2 meningitis or encephalitis risk for the mother. "Herpes simplex virus type 2 (HSV-2) encephalitis is rare, especially during pregnancy. In immunocompetent...

Fc receptor mediates antibody regulation of T-cell immunity.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- Antibody regulation of T-cell immunity against intracellular pathogens is Fc receptor-mediated. "Immunity to intracellular microbial pathogens, including Chlamydia species, is controlled primarily...

Bile acid apoptosis can be blocked by CFLIP-L interacting with p38 MAPK.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- Bile acid mediated apoptosis in cholestasis can be inhibited by CFLIP-L binding p38 MAPK and blocking activation/ phosphorylation. "In cholestasis, toxic bile acids accumulate within the liver...

ICOS may be involved in Peyer patch expansion and IgA, IgG production.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- Peyers patches still form but are smaller in ICOS/B7RP-1 negative mice, but IgA and IgG, not IgM, are reduced. "T-cell co-stimulatory molecule, inducible co-stimulator (ICOS)/B7-related protein-1...

Pharmaceutical companies to identify drug candidates for an allergy target.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- Discovery Partners International, Inc., (DPII) of San Diego, California, and Kyorin Pharmaceutical Co., Ltd., of Tokyo, Japan, announced further details surrounding the collaboration disclosed in the...

Sonic hedgehog mutations cause reduced protein activity, holoprosencephaly.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- Mutations in the Sonic hedgehog gene cause changes in the protein, reduced activity in neural tissue, and some forms of human holoprosencephaly. According to recent research from the United States,...

C1 inhibitor benefits sepsis due to lowering of neutrophil activation.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- The treatment of sepsis patients with C1 inhibitor lowers EA, complement, and IL-8 and thus neutrophil activation. According to a study from Switzerland, "Forty patients with severe sepsis or...

IL-23 and IL-27 are members of family of IL-12 related cytokines.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- Interleukin (IL)-23 and IL-27 are new members of the growing family of IL-12 related cytokines with important implications for therapeutics. "The recent discoveries of the two IL-12-related...

DNA vaccination may be the answer to stable, protective T-cell memory.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- DNA vaccination may be the answer to stable, protective T-cell memory. "Distinct populations of both CD4+ and CD8+ memory T cells have been identified on the basis of their location (lymphoid versus...

The interaction of p53 with its target DNA is stereochemically defined.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- Functionality and binding of p53 are dependent on the target DNA's structure for apparent latency or activation. According to a study from Germany, "The most import biological function of the tumor...

Cerebrospinal fluid can be used to distinguish Alzheimers from CJD.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- Cerebrospinal fluid beta-amyloid ratios can be used to distinguish Alzheimer from Creutzfeldt-Jakob disease. According to recent research published in the journal Annals of Neurology, "Decreased...

NS1 serotype specific IgG ELISA distinguishes primary, secondary infection.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- NS1 serotype specific IgG ELISA can distinguish primary and secondary dengue virus infection, if serum is taken at disease onset, because secondary IgG is not made immediately. According to recent...

IL-18BP can bind IL-18, reduce IFNgamma effects of contact hypersensitivity.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- IL-18 increase in skin during contact hypersensitivity can be blocked by IL-18 binding protein; IFN gamma is lowered, but edema is not affected. "Allergic contact dermatitis, the clinical...

Toxoplasma gondii ELISA can give false-positive IgM due to sphingolipids.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- Toxoplasma gondii ELISA can have unspecific IgM reactivity that corresponds with sphingolipids or ceramides found in pathogen, but not due to infection, in pregnant or grafted patients. "During a...

Recombinant vaccines against Japanese encephalitis developed.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- Researchers have developed recombinant vaccines against Japanese encephalitis. "Japanese encephalitis (JE) is the major form of viral encephalitis in much of the South-East Asia, India, and China....

Vipoma can be extrapancreatic and nonneurogenic but with anti-VIP antibodies.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- Vipoma can be extrapancreatic and nonneurogenic; this case had anti-VIP antibody but was in the liver. According to recent research from Tunisia, "Vipoma is a rare neuroendocrine tumor most...

Matrix metalloproteinases appear to play a role in endometriosis.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- Matrix metalloproteinases may play a role in endometriosis; sometimes this may be in response to steroids. "Retrograde menstruation represents a plausible explanation for the development of most...

The serotype 2 polysaccharide of E. faecalis is made during log phase.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- Enterococcus faecalis serotype 2 polysaccharide has two independent promoters with highest transcription found in log phase. According to a study from the United States, "We previously described a...

Antiepileptic drugs can alter and be altered by other drugs.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- Antiepileptic drugs can alter and be altered by other drugs like antibiotics, hormones, and cardiovascular drugs. According to a study from England, "Antiepileptic drugs (AEDs) are commonly...

Retinopathy can be caused by thymoma, autoantibodies against eye proteins.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- Geriatric retinopathy can be cancer associated; the cancer can produce eye proteins and the body can produce an autoantibody response. "A 60-year-old man was admitted for progressive visual loss in...

Ghrelin induces increased feeding by inducing Fos, thus neuronal activation.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- Ghrelin acts on the hypothalamus to induce increased feeding, by inducing Fos and thus neuronal activation. According to a study from the United States, "Ghrelin stimulates feeding when...

Dawson James Securities initiates coverage of HIV vaccine developer.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- Robert Wasserman, director of Research for Dawson James Securities, a division of ViewTrade Financial, has initiated coverage on Immune Response Corporation (IMNR) with a buy rating and a 12-month price...

Drug transport company reports record operating results for fiscal 2003.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- IOMED, Inc., (IOX) reported financial results for its fourth quarter and fiscal year ended June 30, 2003. For the fourth quarter and fiscal year, IOMED reported net income of $0.04 and $0.10 per...

Grant awarded to develop hepatitis C virus drug susceptibility assay.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- ViroLogic, Inc. (VLGC) has been awarded a grant from the U.S. National Institute of Allergy and Infectious Diseases (NIAID), a division of the U.S. National Institutes of Health, to develop a hepatitis...

Patent allows company to expand position in advanced antisense chemistries.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- Hybridon, Inc., (HYBN) announced the issuance of U.S. patent no. 6,608,035, entitled "Method Of Down-Regulating Gene Expression," claiming methods of orally administering second generation antisense...

Hypothalamic tanycytes have the same molecules to sense glucose as pancreas.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- Hypothalamic glial cells, tanycytes, express the same glucose transporters and K-ATP channel as pancreatic beta cells; thus these cells must be involved in glucose sensing. "The GLUT2 glucose...

Programmed death-1 is involved in protection from GVHD lethality.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- Graft-versus-host (GVHD) disease lethality may be reduced by enhancing programmed death-1, as blockade accelerates GVHD. According to recent research published in the Journal of Immunology, "Acute...

Axonal Guillain-Barre syndrome is more disabling early than demyelinating.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- Axonal pediatric Guillain-Barre is more disabling, has slower recovery from IVIG therapy than the demyelinating form, but at 1 year there is no difference. According to recent research published in...

Phase I trial of autologous VRX496 modified T cells deemed safe.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- VIRxSYS Corporation, a private biotechnology company focused on the development of genetic medicines for the treatment of serious diseases such as HIV/AIDS, announced that an independent Data Safety...

Novel CXCR4 antagonist may prevent HIV-induced neurotoxicity.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- A novel CXCR4 antagonist may help prevent HIV-induced neurotoxicity and dementia. "APJ, a G protein-coupled seven-transmembrane receptor, has been shown to serve as a co-receptor for the entry of...

Intestinal cell cycle dysregulation occurs during SIV infection.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- High-throughput gene expression profiling indicates dysregulation of intestinal cell cycle mediators and growth factors during primary simian immunodeficiency virus infection. According to a study...

Vav prevents HIV Nef-induced GM1 downregulation and NF-AT inhibition.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- The exchange factor Vav prevents HIV Nef-induced GM1 downregulation by T cells, preserving their ability to be activated by the transcription factor NF-AT. "Several findings support the importance...

Baseline immune markers do not predict discordant antiretroviral treatment responses.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- Baseline immune markers cannot be used to predict discordant responses to antiretroviral therapy in HIV patients. "It is unclear why discordant immunologic and virologic responses occur during...

Stavudine treatment, low CD4 cell counts are hypothyroidism risk factors in HIV patients.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- Stavudine treatment and immune suppression increase the risk of thyroid hormone deficiency in HIV patients. Scientists in France conducted a study "to determine the prevalence of and risk factors...

Inflammatory cells support lymphoepithelial lesion angiogenesis.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- Inflammatory cells support lymphoepithelial lesion angiogenesis. According to a study from Japan, "lymphoepithelial lesions (LELs, or epi-myoepithelial islands) in lymphoepithelial sialadenitis...

Pulmonary embolism tends to lead to increased macrophages in right ventricle.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- Pulmonary embolism tends to lead to particular heart damage, increase in macrophages in the right ventricle wall. According to published research from Japan, "To investigate the pathological...

Antigen retrieval using heat, unmasking solutions can be done for electron microscopy.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- Antigen retrieval is possible using heat and various unmasking solutions, in post-embedding immunogold electron microscopy samples. "A novel antigen retrieval procedure was carried out in the...

Cytotoxic T lymphocytes can be generated ex vivo to target multiple myeloma.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- Cytotoxic T lymphocytes can be generated ex vivo to target multiple myeloma. According to a study from the United States, "multiple myeloma (MM) is an incurable plasma cell malignancy characterized...

Low LL-37/hCAP-18 gene expression in human leukemia may give infection risk.
October 1, 2003... 2003 OCT 1 - (NewsRx.com & NewsRx.net) -- LL-37/hCAP-18 gene is expressed at varying, but lower, rates in human leukemia, and may relate to the characteristic susceptibility to infection in patients. According to a study from the Peoples...