Immunotherapy Weekly articles from October 1998

Immunotherapy Weekly archives from October 1998

Cancer Immunotherapy Combination Chemotherapy/Immunotherapy Was Promising in Pilot Study.
October 5, 1998... Stage 4 neuroblastoma in children over one year of age responded to a multifaceted therapy including high-dose chemotherapy (HDCT) with peripheral blood stem cell (PBSC) rescue in combination with (131)I-meta-iodo-benzylguanidine (mIBG) and...

Cancer Immunotherapy Immune Responses Elicited in IL-2 Gene Therapy Trial of Neuroblastoma.
October 5, 1998... Promising results were obtained in an interleukin-2 (IL-2) gene therapy trial of neuroblastoma patients. Several different murine models have demonstrated that the immunogenicity of tumor cells can be increased by transduction with a range...

Conference Coverage (ICAAC) Pneumococcal Vaccine Results Due Next Year.
October 5, 1998... First results from large-scale efficacy trials of conjugate pneumococcal vaccines will become available in 1999. The trials are now underway in the U.S., Finland, and South Africa, reported Juhani Eskola of the National Public Health...

Conference Coverage (ICAAC) Work Remains on Lyme Disease Vaccine.
October 5, 1998... Licensure of a vaccine against Lyme disease is imminent: but much work remains to be done. The recently-approved vaccine is comprised of the recombinant lipidated outer surface protein of the Lyme disease parasite outer surface protein...

Drug Pricing AIDS Groups Protest Pricing of New Dupont Drug.
October 5, 1998... Cheers for Dupont have turned to angry cries. Excitement over U.S. Food and Drug Administration (FDA) approval of Dupont Pharma's anti-HIV drug Sustiva (efavirenz) has been muted by the firm's announcement that the drug's wholesale price...

Cancer Vaccines Research and Development Vaccine Collaboration Announced.
October 5, 1998... SIGA Pharmaceuticals, Inc. and the Ludwig Institute for Cancer Research announced a research and development agreement on vaccines for cancer therapy. The collaboration is focused on the development of novel immunotherapies for melanoma,...

Therapy (HCV) T-Helper Expression Linked to Interferon Response.
October 5, 1998... Both the expansion of hepatitis C virus-specific T-helper cell precursors and T-helper cell recognition of multiple core epitopes appear to be critical to the success of interferon therapy in the treatment of hepatitis C, according to a report...

Immunology Primate Research Study Expanded.
October 5, 1998... Victor Jones, Immune Network, Vancouver, British Columbia, reported that the phase II primate study of its proprietary monoclonal antibody 1F7 on the immune systems of SHIV infected and control primates is nearing completion and now includes a...

HIV Immunotherapy "Adoptive Immunotherapy of HIV Infection with Autologous CD4-Zeta Gene-Modified CD4 and CD8 T Cells.".
October 5, 1998... S. Deeks, R. Mitsuyasu, D. Scadden, L. Connick, P. Anton, D. Broad and K. Hege. San Francisco General Hosp., San Francisco, CA; Univ. of California, Los Angeles, CA; Massachusetts General Hosp., Boston, MA; Univ. of Colorado Health Science...

HIV Immunotherapy "HIV-1 Polymerase Chain Reaction Does Not Always Correlate with Infectious Virus in Patients on Passive Immunotherapy.".
October 5, 1998... A. Karpas, S. Ash and D.R. Bainbridge. Haematology Department, MRC Centre, Cambridge University; Ealing Hospital, London; Royal London Hospital, London, United Kingdom. According to an abstract submitted by the authors to the 12th World...

Immunology (TB) "Macrophage Migration Inhibitory Factor (MIF) Activates Human Macrophages to Restrict the Growth of Mycobacterium tuberculosis.".
October 5, 1998... M. Oddo, T. Calandra, R. Bucala and P.R.A. Meylan. Institute Microbiology and Division Infectious Diseases, Center Hospital University Vaudois, Lausanne, Switzerland; Picower Institute, Manhasset, New York. According to an abstract...

Immunology (TB) "kD ISCOMS: Immune Responses to the 38 kD Lipoglycoprotein from Mycobacterium tuberculosis.".
October 5, 1998... D.P.A.J. Da Fonseca, J. Frerichs, M. Singh, H. Snippet and A.F.M. Verheul. Eijkman-Winkler Institute for Microbiol., Infect. Dis. and Inflammation, Utrecht, The Netherlands; GBF-German National Research Center for Biotechnology, Braunschweig,...

Cancer Immunotherapy "Antigen-Specific Immunotherapy for Murine Lung Metastatic Tumors Expressing Human Papillomavirus Type 16 E7 Oncoprotein.".
October 5, 1998... International Journal of Cancer, September 25, 1998;78(1):41-45. Ji, H.X.; Chang, E.Y.; Lin, K.Y.; Kurman, R.J.; Pardoll, D.M.; Wu, T.C. According to the authors' abstract of an article published in International Journal of Cancer, "An...

Cancer Immunotherapy "Comparative Analysis of Interleukin 15 and Interleukin 2 for Induction of Killer Activity and of Type 2 Cytokine Production by Mononuclear Cells from Lung Cancer Patients.".
October 5, 1998... British Journal of Cancer, September 1998;78(5):616-620. Takeuchi, E.; Yanagawa, H.; Suzuki, Y.; Bando, H.; Sone, S. According to the authors' abstract of an article published in British Journal of Cancer, "Interleukin (IL) 15 is a...

Immunotoxins "A Bivalent Disulfide-Stabilized Fv with Improved Antigen Binding to erbB2.".
October 5, 1998... Journal of Molecular Biology, August 21, 1998;281(3):475-483. Bera, T.K.; Onda, M.; Brinkmann, U.; Pastan, I. According to the authors' abstract of an article published in Journal of Molecular Biology, "We have used protein engineering...

Meningococcal Disease "Induction of Immunologic Refractoriness in Adults by Meningococcal C Polysaccharide Vaccination.".
October 5, 1998... Journal of Infectious Diseases, September 1998;178(3):870-874. Granoff, D.M.; Gupta, R.K.; Belshe, R.B.; Anderson, E.L. According to the authors' abstract of an article published in Journal of Infectious Diseases, "Thirty-four adults were...

Tuberculosis (Drug Resistance) "Mechanisms of Isoniazid Resistance in Mycobacterium tuberculosis: Enzymatic Characterization of Enoyl Reductase Mutants Identified in Isoniazid-Resistant Clinical Isolates.".
October 5, 1998... Journal of Infectious Diseases, September 1998;178(3):769-775. Basso, L.A.; Zheng, R.J.; Musser, J.M.; Jacobs, W.R.; Blanchard, J.S. According to the authors' abstract of an article published in Journal of Infectious Diseases, "Mutants...

Cancer Immunotherapy Combination Antibody/Cytokine Therapy Shows In Vivo Potential.
October 5, 1998... A fusion protein created from a chimeric immunoglobin G (IgG) anti-idiotype (Id) antibody (Ab) and the cytokine interleukin-2 (IL-2) shows promising immunotherapy potential in a B-cell lymphoma model. Previous research has suggested that...

Conference Coverage (ICAAC) Antibody Avidity ID'd As Pneumococcal Immunity Correlate.
October 5, 1998... High-avidity antibodies are a key correlate of protective immunity to pneumococci. The finding comes from a molecular analysis of antibodies produced by healthy adults in response to Streptococcus pneumoniae capsular polysaccharides (PPS)....

Chronic Myelogenous Leukemia NOD/SCID Mice Provide In Vivo Model.
October 5, 1998... The use of non-obese diabetic mice with severe immunodeficiency disease is an appropriate in vivo model of chronic myelogenous leukemia biology, researchers concluded. After a chronic phase (CP), chronic myelogenous leukemia (CML) finally...

Diagnostics (HIV) "Positive Selection of Vpr in Human Immunodeficiency Virus Type 1 Infection and Disease Progression.".
October 5, 1998... N. Saksena, B. Wang and R. Joswiak. Retroviral Genetics Laboratory, Westmead Hospital, Westmead NSW; Westmead Hospital Retroviral Genetics Lab Westmead, NSW, Australia. According to an abstract submitted by the authors to the 12th World...

HPV Vaccine "A Phase I Study of a Recombinant Virus-Like Particle Vaccine against Human Papillomavirus Type 11 in Healthy Adult Volunteers.".
October 5, 1998... R. Reichman, W. Bonnez, D. O'Brien, R. Rose, S. Koenig, J. Suzich, W. White, S. Wilson, J. Balsley, D. Carlin and E. Connor. University of Rochester, Rochester, New York; MedImmune, Inc., Gaithersburg, Maryland. According to an abstract...

Pathogenesis (IL-12) "Activation of Mononuclear Cells by Interleukin-12: An In Vivo Study in Chimpanzees.".
October 5, 1998... F.N. Lauw, A.A. Te Velde, P.E.P. Dekkers, P. Speelman, J.M.F.G. Aerts, C.E. Hack, S.J.H. Van Deventer and T. Van Der Poll. Academic Med. Center, University of Amsterdam, and Central Laboratory of the Netherlands Red Cross Blood Transfusion...

Cancer Immunotherapy "Photoactivated 8-Methoxypsoralen Treatment Causes a Peptide-Dependent Increase in Antigen Display by Transformed Lymphocytes.".
October 5, 1998... International Journal of Cancer, September 25, 1998;78(1):70-75. Hanlon, D.J.; Berger, C.L.; Edelson, R.L. According to the authors' abstract of an article published in International Journal of Cancer, "Ex vivo exposure of malignant...

Monoclonal Antibodies "Expression of Costimulatory Molecule CD40 in Murine Heart with Acute Myocarditis and Reduction of Inflammation by Treatment with Anti-CD40L/B7-1 Monoclonal Antibodies.".
October 5, 1998... Circulation Research, August 24, 1998;83(4):463-469. Seko, Y.; Takahashi, N.; Azuma, M.; Yagita, H.; Okumura, K.; Yazaki, Y. According to the authors' abstract of an article published in Circulation Research, "Evidence has accumulated that...

Conference Coverage (ICAAC) 2 New Flu Drugs Fight For Headlines.
October 12, 1998... Is the flu-drug market big enough for two drugs with similar efficacy and activity? Two firms are ready to find out, and the potential stakes are enormous. Ten to 20 percent of U.S. residents - 26 to 55 million potential customers - get...

Conference Coverage (ICAAC) CDC: Herpes Still Infects Two-Thirds of U.S.
October 12, 1998... Two out of three U.S. residents over the age of 12 years have herpes, reports the U.S. Centers for Disease Control and Prevention (CDC). A CDC study shows that herpes simplex virus type 1 (HSV-1) - most commonly associated with oral cold...

Conference Coverage (ICAAC) Non-Vaccine, Non-Drug Nasal Spray Kills Flu Bugs.
October 12, 1998... It isn't a drug, it isn't a vaccine, but it just might stop the flu. A water-based emulsion developed by Novavax Inc., Rockville, Maryland, kills on contact all types of the influenza virus. The product is not toxic to human cells, and...

Conference Coverage (ICAAC) Primary HIV Infection + HAART: Better Than Vaccine?
October 12, 1998... Patients who receive highly active antiretroviral therapy (HAART) during primary HIV infection may never get AIDS - even if they stop taking the drugs. And with some 44,000 new HIV infections expected in the U.S. in the coming year, a...

Conference Coverage (ICAAC) Unvaccinated Children Protected, But May Pay Later.
October 12, 1998... Children not directly vaccinated are being protected by chickenpox vaccine - but they may later pay a price. A study of chickenpox in daycare centers shows that the decrease in children getting the once-common disease is proportionally...

EBV Dendritic Cells Improve Generation of CTLs.
October 12, 1998... Adoptive transfer of Epstein-Barr virus (EBV)-specific dendritic cells may be effective against posttransplantation EBV-associated lymphoma. The use of immunosuppressive therapies after organ transplantation increases the recipient's risk...

Outbreaks Did HAV Vaccine Stop a Memphis Epidemic? The Jury's Still Out.
October 12, 1998... It is not clear whether a massive vaccination program was instrumental in stopping an outbreak of hepatitis A virus in Memphis, Tennessee. Although hepatitis A cases fell dramatically following the vaccination campaign, it is possible that...

Transplantation Immunotherapy Lipid-Mediated IL-10 Gene Transfer Inhibits Graft Rejection.
October 12, 1998... Inhibition of donor-specific cellular and humoral immune responses by lipid-mediated gene transfer of viral interleukin-10 (vIL-10) prolonged vascularized cardiac allograft survival in vivo. A major complication associated with...

Conference Coverage (ICAAC) Primary Epstein-Barr Virus Infection Often Misdiagnosed.
October 12, 1998... Doctors aren't suspicious enough of primary Epstein-Barr virus (EBV), an Israeli study shows. The herpesvirus responsible for kissing disease causes a chronic infection that has been linked to Burkitt's lymphoma and nasopharyngeal cancer....

Immunology Findings Extend Previously Defined Functions of IL-8.
October 12, 1998... Interleukin-8 stimulates bone marrow to release polymorphonuclear leukocytes into peripheral blood, study findings show. Several studies have demonstrated previously that interleukin-8 (IL-8) causes a rapid granulocytosis with the release...

Immunology Researchers Find Key Immune Response Gene.
October 12, 1998... Researchers said they may have found a gene that acts as a "conductor" that orchestrates the body's entire immune response. The team at British-based Chiroscience Group Plc think they can use the gene as the basis for designing drugs to...

Cancer Immunotherapy "Human Tumor Growth Suppression By Apoptosis Induced With Anti-ErbB-2 Chimeric Monoclonal Antibody.".
October 12, 1998... K. Imai, S. Sasaki, T. Ishida, Y. Hinoda and M. Tsujisaki. First Department of Internal Medicine, Sapporo Medical University, Sapporo, Japan. According to an abstract submitted by the authors to the Eleventh International Conference on...

DNA Vaccines (HIV) "SIV-Specific Cytotoxic T Lymphocytes Induced by DNA Immunization.".
October 12, 1998... M. Robertson, S. Mossman, J.B. Lynch, K. Watanabe, P.D. Greenberg and N.L. Flaigwood. University of Washington, Seattle, Washington; Seattle Biomedical Research Institute, Seattle, Washington. According to an abstract submitted by the...

Radioimmunotherapy "Issues In Radioimmunotherapy Dosimetry.".
October 12, 1998... M.G. Stabin. Oak Ridge Institute for Science and Education, Oak Kidge, Tennessee. According to an abstract submitted by the author to the Eleventh International Conference on Monoclonal Antibodies for Cancer, held March 19-21, 1998, in...

Cancer Immunotherapy "Chimeric Human-Mouse IgG Antibodies with Shuffled Constant Region Exons Demonstrate That Multiple Domains Contribute to in vivo Half-Life.".
October 12, 1998... Cancer Research, September 1, 1998;58(17):3905-3908. Zuckier, L.S.; Chang, C.J.; Scharff, M.D.; Morrison, S.L. According to the authors' abstract of an article published in Cancer Research, "Structural features that determine the...

HBV Vaccines "Economic Evaluation of Different Vaccination Strategies Against Hepatitis B in Children and Adolescents.".
October 12, 1998... Medizinische Klinik, August 15, 1998;93(8):468-477. Szucs, T.D.; Smala, A.; Berger, K.; Windorfer, A. According to the authors' abstract of an article published in Medizinische Klinik, "In this cost-effective study, 4 different vaccination...

Melanoma Vaccines "Correlation of Specific Immune Responses with Survival in Melanoma Patients with Distant Metastases Receiving Polyvalent Melanoma Cell Vaccine.".
October 12, 1998... Journal of Clinical Oncology, September 1998;16(9):2913-2920. Hsueh, E.C.; Gupta, R.K.; Qi, K.; Morton, D.L. According to the authors' abstract of an article published in Journal of Clinical Oncology, "PURPOSE: The mechanisms that underlie...

Therapy (HCV) "Retrospective Analysis of the Effect of Interferon Therapy on the Clinical Outcome of Patients with Viral Cirrhosis.".
October 12, 1998... Cancer, September 1, 1998;83(5):901-909. Benvegnu, L.; Chemello, L.; Noventa, F.; Fattovich, G.; Pontisso, P.; Alberti, A. According to the authors' abstract of an article published in Cancer, "BACKGROUND: Recent data suggest that...

Cancer Immunotherapy "Preparation And Characterization Of A Humanized 520C9 Single-Chain Fv/Human Interleukin-2 Fusion Protein.".
October 12, 1998... J. Li, S.F. Gyorffy, P.C.Y. Liaw, D.B. Ring, J.H. Dove, C.S. Kwok and R.C. Austin. McMaster University, Hamilton, Ontario; Chiron Corporation, Emeryville, California. According to an abstract submitted by the authors to the Eleventh...

Combination Therapy "Effects of Interferon Gamma (IFNgamma) and Interleukin-6 (IL-6) on the Intracellular Growth of L. monocytogenes and Cooperation with Antibiotics in Human Enterocyte-Like Cell Line Caco-2.".
October 12, 1998... Y. Ouadrhiri, Y. Sibille and P.M. Tulkens. University Catholique de Louvain & ICP, Brussels, Belgium. According to an abstract submitted by the authors to the 38th Annual Conference on Cardiovascular Disease Epidemiology and Prevention,...

HIV Vaccines "Effects of a PPD-Pentavalent V3 Loop Penta-Peptide Conjugate Vaccine on Reduction of Viral Loads and HIV V3 Sequence in HIV(+) Subjects.".
October 12, 1998... A. Rubinstein, Y. Mizrachi, J. Lenz, M. Pettoello-Mantovani, G.Q. Liu, H. Goldstein, I. Yust, M. Burke, N. Vardinon, Z. Spirer and S.J. Cryz. Albert Einstein College of Medicine, Bronx, New York; Saurasky Medical Center, University Tel-Aviv,...

Cancer Immunotherapy "Tumor Cell Apoptosis, Lymphocyte Recruitment and Tumor Vascular Changes Are Induced by Low Temperature, Long Duration (Fever-Like) Whole Body Hyperthermia.".
October 12, 1998... Journal of Cellular Physiology, October 1998;177(1):137-147. Burd, R.; Dziedzic, T.S.; Xu, Y.; Caligiuri, M.A.; Subjeck, J.R.; Repasky, E.A. According to the authors' abstract of an article published in Journal of Cellular Physiology, "A...

Therapy (HCV) "Cellular Immunity to Hepatitis C Virus Core Protein and the Response to Interferon in Patients with Chronic Hepatitis C.".
October 12, 1998... Hepatology, September 1998;28(3):815-822. Lasarte, J.J.; Garciagranero, M.; Lopez, A.; Casares, N.; Garcia, N.; Civeira, M.P.; Borrascuesta, F.; Prieto, J. According to the authors' abstract of an article published in Hepatology, "To...

DNA Vaccines (FIV) DNA Vaccine Protects Against FIV Without Inducing Detectable Antibodies.
October 19, 1998... Significant protection was realized against feline immunodeficiency virus (FIV) infection with a DNA vaccine that did not induce detectable levels of antiviral antibodies. DNA-mediated immunization is a promising alternative approach to...

Apheresis Cell Yields are Lower in Second Procedure.
October 19, 1998... Intra-apheresis recruiment of blood progenitor cells may be age-specific. Few comprehensive studies have been reported about the kinetics of blood progenitor cells (BPCs) during apheresis. In hematopoietic transplantation, progenitor...

Asthma (Treatment) Monoclonal Antibody Therapy May Help Severe Chronic Asthma.
October 19, 1998... Injecting patients with antibodies against their own immune cells may be useful in the treatment of severe chronic asthma, researchers working in the United Kingdom and United States recently reported. Asthma is caused by inflammation in...

Hematopoiesis NOD/SCID System Is Useful to Evaluate In Vivo Consequence of Cytokine Treatment.
October 19, 1998... The use of non-obese diabetic/severe-combined immunodeficient (NOD/SCID) mice may be valuable in evaluating cytokine action on human repopulating cells in vivo. Ursula Kapp, Hospital for Sick Children, Toronto, Canada, and colleagues...

TB Immunotherapy Immune System Protein Slays TB Microbe.
October 19, 1998... A protein manufactured by the human immune system kills the bacteria that cause tuberculosis, an international team of scientists has observed in laboratory tests. The discovery, they say, could lead to new treatments for a disease that...

Cancer Immunotherapy Gene-Mediated Suppression of TGF-(beta) Synthesis Inhibits Gliomas In Vivo.
October 19, 1998... In vivo decorin gene transfer suppresses transforming growth factor-(beta) (TGF-(beta)) synthesis and inhibits malignant glioma growth in an animal model. Research suggests that the expression of the immunosuppressive cytokine TGF-(beta)...

Conference Coverage (ICAAC) Next AIDS-Drug Breakthrough Will Focus on New Targets.
October 19, 1998... A wave of new AIDS drugs is ready for clinical testing. But it's the wave after that which is most likely to be revolutionary, says Harvard researcher Scott Hammer. "New agents derived from the existing drug classes... are in...

Cancer Immunotherapy "Outpatient Chemoimmunotherapy for Patents with Metastatic Melanoma.".
October 19, 1998... J.A. Thompson, P.J. Gold, D.R. Markowitz and A. Fefer. University of Washington, Seattle, Washington. According to an abstract submitted by the author to the 8th International Congress on Infectious Diseases, held May 15-18, 1998, in...

Cancer Immunotherapy "Dosimetry Results of Oncolym(Tm) in the Treatment of Refractory B-Cell HL).".Non-Hodgkin's Lymphoma (N.
October 19, 1998... L.I. Verkh, J.L. Murray, C.J. Kripas, B.W. Wessels, V.M. Varma, D. Kahn, D.L. Bushnells, A.N. Serafini and J.C. Oliver. Alpha Therapeutic Corporation; M.D. Anderson; Cornell University; George Washington Medical Center; Iowa City Veterans...

Cancer Immunotherapy "Radioimmunotherapy for Kaposi's Sarcoma: Preclinical Evaluation of the L6 Monoclonal Antibody.".
October 19, 1998... B.R. Leigh, A.M. Hong, R.T. O'Donnell, P. Burke, L. Howell, G.L. DeNardo and S.J. DeNardo. Radiation Oncology, Internal Medicine, Pathology, Radiodiagnosis and Therapy, UC Davis Medical Center, Sacramento, California. According to an...

Cancer Immunotherapy "Endothelial Cells Expressing an Inflammatory Phenotype Are Lysed by Superantigen-Targeted Cytotoxic T Cells.".
October 19, 1998... Clinical and Diagnostic Laboratory Immunology, September 1998;5(5):675-682. Riesbeck, K.; Billstrom, A.; Tordsson, J.; Brodin, T.; Kristensson, K.; Dohlsten, M. According to the authors' abstract of an article published in Clinical and...

Cancer Vaccines "Generation of Human Cytolytic T Lymphocyte Lines Directed Against Prostate-Specific Antigen (PSA) Employing a PSA Oligoepitope Peptide.".
October 19, 1998... Journal of Immunology, September 15, 1998;161(6):3186-3194. Correale, P.; Walmsley, K.; Zaremba, S.; Zhu, M.Z.; Schlom, J.; Tsang, K.Y. According to the authors' abstract of an article published in Journal of Immunology, "Prostate specific...

Cancer Vaccines "MAGE, BAGE and GAGE: Tumour Antigen Expression in Benign and Malignant Ovarian Tissue.".
October 19, 1998... British Journal of Cancer, September 1998;78(6):816-821. Gillespie, A.M.; Rodgers, S.; Wilson, A.P.; Tidy, J.; Rees, R.C.; Coleman, R.E.; Murray, A.K. According to the authors' abstract of an article published in British Journal of Cancer,...

Gene Delivery "Stable and Monodisperse Lipoplex Formulations for Gene Delivery.".
October 19, 1998... Gene Therapy, September 1998;5(9):1272-1282. Zelphati, O.; Nguyen, C.; Ferrari, M.; Felgner, J.; Tsai, Y.; Felgner, P.L. According to the authors' abstract of an article published in Gene Therapy, "A stable single vial lipoplex formulation...

Cancer Immunotherapy "Chemoimmunotherapy in Stage IV Melanoma: The EORTC-Melanoma Cooperative Group Program.".
October 19, 1998... A.M.M. Eggermont. EORTC-MCG. According to an abstract submitted by the author to the 8th International Congress on Infectious Diseases, held May 15-18, 1998, in Boston, Massachusetts, "Phase II-III trials regarding the efficacy of...

Cancer Immunotherapy "Milestones in the Development of Lym-1 Radioimmunotherapy.".
October 19, 1998... G.L. DeNardo, S.J. DeNardo, L.A. Kroger, D.S. Goldstein, K.R. Lamborn, S. Shen and R.T. O'Donnell. University of California Davis Medical Center, Sacramento, California. According to an abstract submitted by the authors to the Eleventh...

Cancer Immunotherapy "Characterization of a Novel Bispecific Antibody That Mediates Fc gamma Receptor Type I-Dependent Killing of Tumor-Associated Glycoprotein-72-Expressing Tumor Cells.".
October 19, 1998... Clinical Cancer Research, September 1998;4(9):2237-2243. Russoniello, C.; Somasundaram, C.; Schlom, J.; Deo, Y.M.; Keler, T. According to the authors' abstract of an article published in Clinical Cancer Research, "A bispecific antibody was...

Cancer Immunotherapy "Prevention of Intestinal Toxic Effects and Intensification of Irinotecan's Therapeutic Efficacy Against Murine Colon Cancer Liver Metastases by Oral Administration of the Lipopeptide JBT 3002.".
October 19, 1998... Clinical Cancer Research, September 1998;4(9):2053-2063. Shinohara, H.; Killion, J.J.; Kuniyasu, H.; Kumar, R.; Fidler, I.J. According to the authors' abstract of an article published in Clinical Cancer Research, "The induction of...

Leukemia "Granulocyte-Macrophage Colony-Stimulating Factor Induces the Differentiation of Murine Erythroleukaemia Cells into Dendritic Cells.".
October 19, 1998... Immunology, September 1998;95(1):141-147. Cao, Y.; Zhao, Y.; Yu, Y.; Wang, Y.; Zhang, M.; Zhang, W.; Wang, J. According to the authors' abstract of an article published in Immunology, "Dendritic cells (DC) are professional...

Cancer Immunotherapy Retroviral Vector Successfully Transduces hIFN-(alpha)2 Into Leukemic Cells.
October 26, 1998... The successful transduction of human leukemic cell lines by a defective retroviral vector encoding human interferon-(alpha)2 (hIFN-(alpha)2) brings a potential cancer immunotherapy one step closer to a clinical reality. In several other...

Bone Marrow Transplantation Absence of Perforin Affects Ability to Prevent Rejection.
October 26, 1998... Cytotoxicity mediated by perforin- or Fas ligand-dependent mechanisms is necessary for donor T cells to prevent allogeneic marrow rejection. Donor CD8 cells play a dominant role in preventing allogeneic marrow graft rejection in mice, and...

Case Report Flutamide-Induced Hepatitis Reported.
October 26, 1998... Researchers in Italy report a case of flutamide-induced acute hepatitis in an elderly man with prostate cancer. Flutamide is a nonsteroidal antiandrogen drug used in the treatment of prostatic cancer. Hepatotoxic reactions due to flutamide...

Therapy (HCV) Daily Initial IFN Therapy Beneficial.
October 26, 1998... Daily administration of interferon may be beneficial in patients with chronic hepatitis C virus at the beginning of therapy, according to a report from Japan. "This study suggests that initial daily interferon administration is necessary...

Cancer Immunotherapy Transgene Expression in Dendritic Cells Induces T Cell Responses.
October 26, 1998... Transgene expression of tumor-associated antigens (Ags) in dendritic cells (DC) induced antigen-specific cytotoxic T cell responses in healthy donor cells in vitro. Immunization with Ag-loaded DC has the potential to be a powerful...

Malaria Plasmid Encoding GM-CSF May Enhance DNA Vaccines.
October 26, 1998... Plasmids may be useful in the enhancement of malaria DNA vaccines. Using the murine parasite Plasmodium yoelii (Py) as a model for the development of a malaria vaccine, U.S. Naval Medical Research Institute researchers previously...

Cancer Vaccines (ASN Conference News) Immunotherapy with Genetically Manipulated Cells Promising for Renal Cell Cancer.
October 26, 1998... Immunotherapy with genetically manipulated cells offers a promising new approach to the treatment of metastatic renal cell carcinoma, according to study findings announced at the American Society of Nephrology 31st annual meeting held October...

Industry News (Joint Venture) Autologous Cancer Vaccine Collaboration Established.
October 26, 1998... Antigenics, LLC, New York, New York, announced that they have entered into a strategic collaboration with Sigma-Tau in Italy to launch clinical trials in Italy using Antigenics' proprietary heat shock protein (HSP) vaccines. Sigma-Tau...

Radioimmunotherapy "Evaluation of CH2 Deleted HuCC49 for Intraperitoneal Radioimmunotherapy.".
October 26, 1998... D.J. Buchsbaum, M.B. Khazaeli, M.S. Mayo, P. Horan Hand, J. Schlom and R.F. Meredith. Departments of Radiation Oncology and Medicine, University of Alabama at Birmingham, Birmingham, Alabama; Laboratory of Tumor Immunology and Biology,...

Cancer Immunotherapy "Anti Tumor Effects on Mouse Melanoma Elicited by Local Secretion of Interleukin-12 and Their Enhancement by Treatment with Interleukin-18.".
October 26, 1998... I. Hara, H. Nagai, K. Yamanaka, S. Hara, H. Miyake, K. Gohji, S. Arakawa and S. Kamidono. Department of Urology and Department of Dermatology, Kobe University School of Medicine, Kobe, Japan. According to an abstract submitted by the...

Radioimmunotherapy "Therapy of Refractory Non-Hodgkin's Lymphoma (NHL) With (131)I-LL2 (ANTI-CD22) Radioimmunotherapy (RIT): Results of a Repetitive Dosing Trial.".
October 26, 1998... J. Vose, D. Colcher, P. Bierman, L. Gobar, M. Hohenstein, S. Augustine, D. Goldenberg, M. Tempero and J. Armitage. University of Nebraska Medical Center, Omaha, Nebraska; Imunomedics, Inc., Morris Plains, New Jersey. According to an...

Arthritis "The Specificity of Peptides Bound to Human Histocompatibility Leukocyte Antigen (HLA)-B27 Influences the Prevalence of Arthritis in HLA-B27 Transgenic Rats.".
October 26, 1998... Journal of Experimental Medicine, September 7, 1998;188(5):877-886. Zhou, M.; Sayad, A.; Simmons, W.A.; Jones, R.C.; Maika, S.D.; Satumtira, N.; Dorris, M.L.; Gaskell, S.J.; Bordoli, R.S.; Sartor, R.B.; Slaughter, C.A.; Richardson, J.A.;...

Cancer Immunotherapy "BCG-Activated Killer Cells: In vitro Study of Specific Recognition and Killing Mechanisms of Intravesical Immune Therapy with BCG.".
October 26, 1998... Aktuelle Urologie, August 1998;29(4):175-187. Bohle, A.; Durek, C.; Schafer, I.; Brandau, S.; Ulmer, A.J.; Flad, H.D.; Jocham, D. According to the authors' abstract of an article published in Aktuelle Urologie, "Adjuvant intravesical...

Cancer Immunotherapy "Induction of Anti-Idiotypic Humoral and Cellular Immune Responses by a Murine Monoclonal Antibody Recognizing the Ovarian Carcinoma Antigen CA125 Encapsulated in Biodegradable Microspheres.".
October 26, 1998... Cancer Immunology Immunotherapy, September 1998;47(1):13-20. Ma, J.; Samuel, J.; Kwon, G.S.; Noujaim, A.A.; Madiyalakan, R. According to the authors' abstract of an article published in Cancer Immunology Immunotherapy, "The use of...

Peptide Immunization "IFN-gamma-Secreting T-h Cells Regulate Both the Frequency and Avidity of Epitope-Specific CD8(+) T Lymphocytes Induced by Peptide Immunization: An ex vivo Analysis.".
October 26, 1998... International Immunology, September 1998;10(9):1273-1279. Romieu, R.; Baratin, M.; Kayibanda, M.; Guillet, J.G.; Viguier, M. According to the authors' abstract of an article published in International Immunology, "CD8(+) T lymphocytes are...

Dermatology (Lyell's Syndrome) IVIG Treatments Block Apoptosis Causing Necrotic Skin Disease.
October 26, 1998... Imagine having a drug reaction so strong you lose large sections of your skin. That's what happens to those afflicted with toxic epidermal necrolysis (TEN, or Lyell's syndrome). Researchers I. Viard et al. in Switzerland may have...

Cancer Immunotherapy "A Gene Encoding Tumor Antigenic Peptides of Human Squamous Cell Carcinoma Recognized by Cytotoxic T Lymphocytes.".
October 26, 1998... K. Itohi, S. Shichijo, M. Nakao, Y. Imai, M. Kikuchi, H. Takasu and H. Yamana. Departments of Immunology and Surgery, Kurume University School of Medicine, Cancer Vaccine Division of Kurume University Research Center for Innovative Cancer...