Immunotherapy Weekly articles from November 2003

Immunotherapy Weekly archives from November 2003

High IgG levels against murine leukemia virus are found in human psoriasis.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- Human endogenous retroviruses of the murine leukemia virus family may be the cause of psoriasis as IgG is high in patients, but are highly prevalent in humans. "Increasing evidence suggests that...

Finely tuned analyses depict the dynamics of antibody to HBV X protein.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- Finely tuned analyses depict the dynamics of antibody to HBV X protein. "The recombinant form of the 17 kDa, highly hydrophobic and disulfide-bonded hepatitis B virus X protein (HBX) was used for...

The changing face of severe asthma: Boys in childhood and women as adults.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- Almost two out of three children with severe asthma are boys. But women account for more than two out of three adults with severe asthma. And no one really knows why. Those are some of the most...

Gene profiling can identify forms of leprosy; elucidates immune evasion.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- Gene profiling can identify forms of leprosy and elucidate immune evasion tactics. According to published research from the United States, "Leprosy presents as a clinical and immunological spectrum...

Bone loss is specific on ultrasounds of those with early rheumatoid arthritis.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- Bone loss is specific on ultrasounds of those with early rheumatoid arthritis. According to a study from Japan, "rheumatoid arthritis (RA) is a major cause of secondary osteoporosis and is...

CTL in vitiligo patients react to gp100, not MelanA/MART-1 or tyrosinase.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- Of melanocyte antigens gp100, MelanA/MART-1, and tyrosinase, only gp100 stimulated cytotoxic T lymphocyte reactivity in vitiligo patients. According to recent research published in the Journal of...

FDA grants anti-CD4 drug fast-track status for the treatment of HIV-1.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- Tanox, Inc., (TNOX) announced that the U.S. Food and Drug Administration (FDA) has granted fast-track status to TNX-355 for the treatment of patients with human-immunodeficiency virus 1 (HIV-1)...

Liver transplant tacrolimus neurotoxicity may be preceded by leukoencephalopathy.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- Liver transplant neurotoxicity following tacrolimus may be preceded by leukoencephalopathy. According to recent research published in the journal Liver Transplantation, "Neurotoxicity is a...

Families with periodontitis have elevated levels of IgG2 that are inherited.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- Families with aggressive periodontitis are found to have elevated levels of IgG2 that are inherited. According to a study from the United States, "IgG2 is elevated in localized but not in...

Asthma may occur due to vagal reflex stimulation from gastroesophageal reflux.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- Vagal reflex stimulation may be involved in the airway hyperresponsiveness that can accompany gastroesophageal reflux. "Airway hyperresponsiveness is among the defining phenomena in asthma. In this...

Tri-Nasal Nasal Spray acquired from Muro Pharmaceutical.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- Collegium Pharmaceutical, Inc., a closely held specialty pharmaceutical company, announced that it has acquired from Muro Pharmaceutical, Inc., all rights to Tri-Nasal (triamcinolone acetonide, USP)...

Avoiding pets may not prevent allergies.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- Exposure to high levels of cat allergen as a child may prevent the development of allergies, according to a study published in the Journal of Allergy and Clinical Immunology (JACI). Researchers...

CD226 is on nonresting human endothelial cells, allows adhesion of leukocytes.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- The transmembrane glycoprotein CD226 is involved in adhesion of leukocytes to endothelial cells and in endothelial cells it is an inducible molecule. According to recent research published in the...

P-glycoproteins for multidrug resistance are in Haemonchus contortus, eggs.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- Nematode eggshells and adults of Haemonchus contortus contain P-glycoproteins involved in multidrug resistance, although individual parasites have different degrees of it. "The multidrug resistance...

IL-17 alone may enhance osteosarcoma cell lysis by natural killer cells.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- Osteosarcoma cells have receptors to IL-17; IL-17 alone may enhance lysis by NK cells, but with IFNgamma they resist NK more. "We investigated the effect of the proinflammatory cytokine interleukin...

Virus delivered nitroreductase/CB1954 acts synergistically with 5-FU on cancer.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- The enzyme-prodrug combination nitroreductase/CB1954 creates cancer cell apoptosis by the caspase pathway, and acts synergistically with 5-fluorouracil. According to published research from England,...

Passive immunotherapy appears to be an effective way to treat melanoma.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- Passive immunotherapy should soon be a recognized way of effectively treating melanoma. According to recent research published in the journal Bulletin du Cancer, "The protocols of tumor...

The asparaginyl endopeptidase inhibitor, acyloxymethylketone, is cell-permeable.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- The potent asparaginyl endopeptidase inhibitor, acyloxymethylketone, is cell-permeable; alters antigen presentation. "Mammalian asparaginyl endopeptidase (AEP) or legumain is a recently identified...

The C-terminal domain of human CAP18 was used to develop more active analogues.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- The C-terminal domain of human antibacterial protein CAP18 was used as a base to develop 2 proteins with stronger antibacterial effect. "This paper reports the effect of the synthesized 27-amino...

Innate antimicrobials are important, despite some bacterial immune evasion.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- Antimicrobial peptides are involved in innate immune defense against bacteria, and bacteria have evolved some ways to evade these molecules. According to recent research published in the journal...

Interferons alpha and beta act on p53; do have antitumor, antiviral activities.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- Interferons alpha and beta collaborate with p53, effecting tumor suppression and antiviral effects; new types of interferon or better targeted delivery may be clinically effective. "In the recent...

Catheter insertion site can make a difference for apheresis patients.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- The site of insertion and other aspects concerning catheters can make a difference for apheresis patients. According to published research from Germany, "In the intensive care unit, apheresis...

Rheumatoid arthritis treatment studied in phase II trial.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- Regeneron Pharmaceuticals, Inc., (REGN) announced that the company's IL-1 Trap demonstrated evidence of efficacy and safety in patients with rheumatoid arthritis (RA) in a phase II dose-ranging study in...

Phase II study initiated to evaluate recombinant alpha 1-antitrypsin gel.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- ProMetic Life Sciences (TSX: PLI) and Arriva Pharmaceuticals, Inc., announced that their joint venture company, Arriva-ProMetic, Inc., (JV), has opened a phase II clinical study to evaluate its lead...

Two phase IIa trials initiated in dermatology.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- Encysive Pharmaceuticals (ENCY) announced that its majority-owned German affiliate, Revotar Biopharmaceuticals AG, initiated two double-blind, placebo, and standard drug controlled phase IIa clinical...

CD8 + chronic lymphocytic leukemia had other markers, cytokines expressed.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- In atypical chronic lymphocytic leukemia cells expressing CD8, there are a series of other unique immune markers and cytokines expressed. According to a study from Mexico, "Atypical chronic...

B7-H3 may be a negative Th1 regulator and may prevent some autoantibodies.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- B7-H3 is involved in downregulation of Th1 responses and lack of it can produce more autoantibodies, experimentally. "We investigated the in vivo function of the B7 family member B7-H3 (also known...

Regulatory T cells have role in protection from autoimmunity.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- Regulatory T cells are a diverse population of T cells involved in protecting against autoimmunity, and may be used therapeutically in the future. According to recent research published in the...

AID may not need cofactors in somatic hypermutation, but may in class-switch.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- Activation-induced cytidine deaminase does not appear to need cofactors in B-cell somatic hypermutation signalling but may need them in class switch. "Activation-induced cytidine deaminase (AID) is...

Fas can induce apoptosis in B cells, but other surface receptors may intervene.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- Fas can induce apoptosis in B cells, but other surface receptors determine to susceptibility to it, unlike other cells. "Engagement of the cell surface receptor Fas/APO-1 (CD95) initiates a...

Dendritic cells battle meningococcal, listerial meningitis two separate ways.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- Dendritic cells function by two different pathways to combat bacterial meningitis from Listeria monocytogenes and Neisseria meningitides. "Few bacteria are capable of causing infections of the...

Nerve tissue from cattle is still disseminated during slaughter; is a BSE risk.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- Nerve tissue from cattle is still disseminated during slaughter and is a BSE risk. According to a study from Ireland, "In the absence of reliable live animal tests for the presence of BSE in cattle,...

Study of novel anticancer agent gets boost from $3M grant.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- Roswell Park Cancer Institute (RPCI) has been awarded a Clinical Translational Research Grant of $3,089,794 by the Breast Cancer Research Program of the U.S. Department of Defense for the study of a...

Brucellosis patient sera reacts to aminopeptidase N purified from Brucella.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- Acute and chronic brucellosis patient sera reacts to an aminopeptidase N purified from Brucella. According to a study from Mexico, "An immunogenic aminopeptidase was purified from Brucella...

C. jejuni cytolethal distending toxin subunits A, C allow binding to cells.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- Campylobacter jejuni cytolethal distending toxin subunits CdtA and CdtC allow the complex to bind to cells; they also can compete with the active complex that includes the CdtB nuclease. ...

Antigen-specific immunotherapy and cancer vaccines reviewed.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- Scientists have published a review of antigen-specific immunotherapy and cancer vaccines in a recent issue of the International Journal of Cancer. "The specific activation of the immune system to...

Clinical studies of vaccines targeting breast cancer reviewed.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- Investigators have published a review of clinical studies of vaccines targeting breast cancer in a recent issue of the journal Clinical Cancer Research. "Many clinical studies have been undertaken...

Dendritic cell vaccine induces T-cell immunity in stage IV melanoma patients.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- Single injection of CD34+ progenitor-derived dendritic cell vaccine can lead to induction of T-cell immunity in patients with stage IV melanoma. According to a study from the United States, "There...

Heat shock protein from a non-autologous tumor used as anti-tumor vaccine.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- Heat shock protein derived from a non-autologous tumor can be used as an anti-tumor vaccine. According to published research from Ireland, "Antigenic cross-reactivity between certain tumors has...

Her-2/neu is potential vaccine target for acute lymphoblastic leukemias.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- The Her-2/neu antigen is a potential vaccine target for acute lymphoblastic leukemias. "Her-2/neu is a tumor-associated antigen that is expressed on several adenocarcinomas and correlates with poor...

Immunogene vaccine improves outcome after combination therapy for myeloma.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- Immunogene vaccination improved the outcome after combination therapy for myeloma murine myeloma. According to a study from Canada, "Increasing evidence suggests a role for immunologic vaccination...

Skin, normally below physiologic temperature, enables C. albicans mating.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- Skin that is normally below physiologic temperature is at conditions favorable for Candida albicans to mate. "Mating between natural a/a and alpha/alpha strains of Candida albicans requires that...

The nectin family of molecules are involved in adhesion, mobility, polarization.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- Nectins and nectin-like molecules appear to play an important part in cell adhesion, mobility, and polarization. According to recent research published in the journal Cancer Science, "Nectins are a...

ICOS to manufacture clinical antibody candidate, M200.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- ICOS Corp. (ICOS) announced that it has entered into a manufacturing agreement with Protein Design Labs (PDL), Inc., (PDLI), a biopharmaceutical company based in Fremont, California. Under the...

Phosphoglycerate kinase is in C. sinensis; may be required for movement.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- Phosphoglycerate kinase can be found in several parts of adult Clonorchis sinensis, and may be involved in energy production for muscle contraction and movement. "Phosphoglycerate kinase (PGK) is...

Fibrin polymerization rate in antiphospholipid syndrome plus SLE may be a risk.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- Patients with antiphospholipid syndrome plus lupus have an increased fibrin polymerization rate that may be a clotting risk. "The main event in blood coagulation is the thrombin-catalyzed...

Ischemic colitis patients have lower protein Z, thus risk hypercoagulability.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- Patients with ischemic colitis have a higher risk of clotting complications than diverticulitis patients or normal controls, due to lower plasma protein Z. "Hypercoagulable states have been...

Chinese medicine uses the seahorse; molecular profiling reveals many lectins.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- Chinese traditional medicine uses the seahorse; elucidation into its immunology may yield information related to its effect in humans. According to recent research published in the journal FEBS...

Crohn disease drug therapies will nearly double to $1.2 billion in 2012.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- Decision Resources, Inc., finds that sales of Crohn disease (CD) drug therapies will increase from $713 million in 2002 to nearly $1.2 billion in 2012. According to a new Pharmacor study entitled...

Gene mutation responsible for inflammation identified.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- A mutation in one of the genes that might be responsible for the inflammation that characterizes Crohn disease has been identified by researchers at Temple University's School of Medicine (TUSM). ...

Cryptococcus neoformans has a MATa strain that has a multifunctional CPRa.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- Cryptococcus neoformans has a MATa strain that has a multifunctional CPRa; it's a pheromone receptor, virulence factor, and growth regulator. "Cryptococcus neoformans is the etiologic agent of...

Cryptosporidium parvum kills the host cell on egress.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- The parasite Cryptosporidium parvum kills the host cell as it leaves. According to published research from the United States, "Cryptosporidium parvum is an intracellular protozoan parasite that...

Antibodies to CFTR recognize protein in human, mouse lung, colon epithelium.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- Cystic fibrosis transmembrane conductance regulator protein is easily detectable by all antibodies in both human and mouse respiratory and colonic epithelium. According to a study from Portugal,...

Yeast can be made to do V(D)J recombination with murine RAG1 or RAG2.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- Yeast can be made to do V(D)J recombination with murine RAG1 or RAG2. "Antigen receptor genes are assembled during lymphoid development by a specialized recombination reaction normally observed...

Anti-infective ability of DC should be studied to apply to anticancer efforts.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- Dendritic cell based anticancer immunotherapy research should encompass anti-infectious response research. "Dendritic cells (DC) are the most potent antigen-presenting cells (APC) that initiate T...

Paraneoplastic pemphigus can occur with hepatocellular carcinoma, too.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- Paraneoplastic pemphigus can occur with hepatocellular carcinoma, too. According to a study from Austria, "Paraneoplastic pemphigus (PNP) is an autoimmune mucocutaneous blistering disease associated...

ALP from the fluid of sterile and fertile E. granulosus cysts charactierized.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- Alkaline phosphatase from fertile Echinococcus granulosus cysts is better than from sterile ones in identifying patient immunoreactivity. According to recent research from Iran, "Alkaline...

Sociability may reduce the probability of catching the common cold.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- Sociability, but not the quality of it or health practices, may reduce the probability of catching colds. "There is considerable evidence that social relationships can influence health, but only...

EBV mononucleosis with thrombocytopenia can have anti-platelet autoantibodies.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- EBV mononucleosis can cause immune thrombocytopenia, with autoantibodies to platelet glycoproteins present. "In this study, we detected autoantibodies to platelet glycoproteins GPIIb/IIIa and...

E. coli O157:H7 virulence is due to the DeltatatABC genes.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- Enterohemorrhagic Escherichia coli O157:H7 cytotoxicity is due to DeltatatABC; it affects shiga toxin and flagellin. According to recent research from France, "Shiga toxin producing Escherichia...

Lactoferrin appears to have serine protease activity against bacterial proteins.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- Lactoferrin, found in human milk, can degrade enteropathogenic E. coli proteins involved in attachment and pore formation; this antibacterial action can work on other bacteria that use the same system....

Substandard fungal allergy diagnostics, therapy may improve with new technology.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- Diagnosis and immunotherapy in fungal allergy are substandard; recombinant technology may help improve them. "For decades, airborne fungal spores have been implicated as causative factors in...

Persistent pediatric gastroenteritis may be due to astrovirus serotype-3.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- Persistent pediatric gastroenteritis may be due to astrovirus serotype-3. "The relationship between cases of persistent diarrhea and the levels and type of human astrovirus was investigated,"...

Syngeneic bone marrow transplant patients do have graft-versus-host disease risk.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- Syngeneic bone marrow transplant patients can get a graft-versus-host disease type syndrome. According to a study from the United States, "Rappeport first reported the clinical syndrome of...

Most M non-typeable group A streptococci can be given an M type following FIGE.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- Most M non-typeable group A streptococci can now be grouped with a corresponding M type if run on FIGE. According to published research from the United States, "Group A streptococcus (GAS) are...

HLA-B22 alleles linked to rapid disease progression in white HIV patients.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- HLA-B22 alleles exert a potent influence over the course of HIV infection in white patients. "The human leukocyte antigen (HLA)-B22 serogroup - which consists of the alleles B*54, B*55, and B*56 -...

SHIV Nef ITAM deletions linked to loss of virulence in macaques.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- Deletions in the ITAM motif of simian-human immunodeficiency virus (SHIV) Nef protein cause of loss of virulence in macaques. According to published research from France, "SHIVsbg, expressing Vpu,...

Genetic therapy options for HIV patients reviewed.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- Gene therapy options for HIV patients have been reviewed. "Despite the tremendous success of highly active antiretroviral treatment (HAART) introduced nearly eight years ago for the treatment of...

HIV sensitivity to RANTES neutralization can mark disease progression.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- HIV sensitivity to RANTES neutralization can be used to help mark disease progression. "In approximately half of human immunodeficiency virus (HIV) type 1-infected individuals, the development of...

Reduced NCR expression underlies NK cell dysfunction during HIV infection.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- Reduced NCR expression underlies NK cell dysfunction during HIV infection "Signals leading to NK cell triggering are primarily mediated by natural cytotoxicity receptors (NCR) upon binding to...

CSF analysis vital for diagnosis of opportunistic CNS infections in HIV patients.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- CSF analysis is vital for the diagnosis of opportunistic CNS infections in HIV patients. "In up to 50% of all human immunodeficiency virus (HIV) patients, the nervous system is clinically involved,"...

Some HIV-2 strains don't use normal HIV coreceptors.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- Some HIV-2 strains don't use the normal HIV coreceptors for cell entry. "In vivo, human immunodeficiency virus type 2 (HIV-2) infection reveals several unique characteristics when compared to HIV-1...

Yeast model aids study of CCR5 activation.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- A yeast model has enabled a detailed characterization of CCR5 signaling. "CCR5 is a G protein-coupled receptor for RANTES, MIP-1alpha, MIP-1beta, and MCP-2 that functions as the front line...

Antiretroviral treatment can impair antimalarial immune activity.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- Antiretroviral treatment can impair antimalarial immune activity. "In response to the HIV/AIDS pandemic, antiretroviral treatment is currently being implemented in sub-Saharan Africa, where malaria...

Indinavir suppresses transendothelial migration of immature dendritic cells.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- The anti-HIV agent indinavir (IDV) suppresses the transendothelial migration of some immature immune cells. IDV "is a protease inhibitor that successfully suppresses HIV-1 replication as part of...

Nicotinamide riboside transporter is needed for H. influenzae survival.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- Haemophilus influenzae needs pnuC to survive in vivo; this may be a good target for therapy. "The gene for the nicotinamide riboside (NR) transporter (pnuC) was identified in Haemophilus...

H. pylori HP1361 ORF is essential for transformation.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- HP1361 ORF of Helicobacter pylori is a comE3 homolog of Bacillus subtilis, and is essential for DNA binding and uptake during transformation. According to published research from Taiwan, "To find...

H. pylori histidine kinases, response regulators affect virulence.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- Helicobacter pylori histidine kinases and response regulators are involved in attachment, colonization, and bacterial competition; thus control virulence. According to recent research published in...

Pepsinogens I, II are high in patients with H. pylori, lower after cure.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- Pepsinogens I and II are high in patients with Helicobacter pylori, lower after undergoing cure, and may be related to symptoms in peptic ulcer disease. "There are some reports the gastric atrophy...

Steroid resistant HCV-related autoimmune disorders respond to alternate therapy.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- Steroid resistant HCV-related autoimmune disorders respond to alternate therapy. "We report two cases of hepatitis C virus (HCV) associated autoimmune hematological disorders successfully treated...

Virosome hepatitis A vaccine efficacious in young children in Nicaragua.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- Results from a randomized placebo-controlled trial indicate that a virosome hepatitis A vaccine is efficacious in young children in Nicaragua. "Immunization of young children could control hepatitis...

Herpes simplex virus induces the chemokine RANTES/CCL5.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- Herpes simplex virus infection induces the chemokine RANTES/CCL5; IRF-3, NF-kappaB are involved. According to published research from Denmark, "Chemokines regulate migration of leukocytes to sites...

Double immunostaining depends on glycine washes, blocking, dye type, mounting.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- Double autoimmunostaining can depend of glycine washes, nonspecific blocking, type of dye, and mounting medium. According to recent research from Japan, "Double autoimmunostaining by a sequential...

Adjuvant licensed for the development of HIV vaccine.
November 5, 2003... 2003 NOV 5 - (NewsRx.com & NewsRx.net) -- The Immune Response Corporation (IMNR) and Hybridon, Inc., (HYBN) have entered into a license agreement for the use of Amplivax as an adjuvant in the development of a novel vaccine candidate for the...