Immunotherapy Weekly articles from November 2000

Immunotherapy Weekly archives from November 2000

Sublingual Immunotherapy May Be Effective Long-Term Treatment for Children.
November 1, 2000... 2000 NOV 1 - (NewsRx.com) -- Sublingual immunotherapy is a safe and effective method for the long-term treatment of pediatric asthma patients, despite having little apparent effect on immunologic variables, researchers report in the...

Adoptive Immunotherapy Lowers Risk of Postsurgical Recurrence.
November 1, 2000... 2000 NOV 1 - (NewsRx.com) -- Adoptive immunotherapy can reduce postsurgical recurrence of hepatocellular carcinoma (HCC), say researchers in Japan. "Postsurgical recurrence of HCC is frequent and fatal," stated T. Takayama and...

Gene Therapy Used to Redirect Anti-Cancer Immune Responses.
November 1, 2000... 2000 NOV 1 - (NewsRx.com) -- Researchers in the United States explored the effectiveness of antigen-specific lymphocyte expansion (ALEX) for its ability to redirect immune responses against target tumors. "Tumor escape from immune...

Therapy Improves Air Flow But Not Nitric Oxide Levels.
November 1, 2000... 2000 NOV 1 - (NewsRx.com) -- Conventional treatments for seasonal allergic rhinitis produce improvements in objective measures of nasal airflow and subjective symptom experience, but do not affect nasal nitric oxide levels, according to a...

New Antibody Test Developed.(autonomic disorders )
November 1, 2000... 2000 NOV 1 - (NewsRx.com) -- Mayo Clinic, Rochester, Minnesota, researchers have developed a new test that will help physicians distinguish autonomic disorders caused by the immune system from other autonomic disorders, allowing for more...

Roquinimex Immunotherapy is Associated With Dermatologic Changes.
November 1, 2000... 2000 NOV 1 - (NewsRx.com) -- Immunotherapy with roquinimex may cause dermatologic graft-vs.-host disease reactions, a recent study found. "Roquinimex (Linomide) is an immunotherapeutic agent used in conjunction with autologous bone...

Cytokine Therapy Shows Promise in Cancer Models.
November 1, 2000... 2000 NOV 1 - (NewsRx.com) -- Cytokine gene delivery using electroporation slowed tumor growth and improved survival in a murine model, researchers in the United States reported. "Cytokines are utilized as adjuvants to traditional...

Electroporation Enhances Numerous Therapies.
November 1, 2000... 2000 NOV 1 - (NewsRx.com) -- Electroporation can be used to enhance the effectiveness of numerous therapeutic modalities. "The development of effective therapies for a variety of diseases is dependent on procedures that allow for...

Simple Sugar May Prevent Lung Infections in CF Patients.(cystic fibrosis )
November 1, 2000... 2000 NOV 1 - (NewsRx.com) -- The lungs contain substances that kill inhaled and aspirated bacteria, thereby preventing lung infections. This system may be disrupted in people with cystic fibrosis (CF). University of Iowa researchers...

Anti-CD45RO Immunotoxin Eliminates Latently Infected CD4(+) Cells.
November 1, 2000... 2000 NOV 1 - (NewsRx.com) -- Researchers in the United States demonstrated that an anti-CD45RO immunotoxin was able to eliminate latently infected CD4(+) cells from HIV infected patients. "Several studies have demonstrated that...

HIV-1 Envelope-Specific Lymphocytes Stimulated by Semi-Allogeneic Cell Hybrids.
November 1, 2000... 2000 NOV 1 - (NewsRx.com) -- According to a study from the United States, semi-allogeneic cell hybrids stimulated HIV-1 envelope-specific cytotoxic T lymphocytes (CTL) in vitro. "The present study was designed to determine whether the...

G-CSF Inhibits Immune Reconstitution After Mismatched Transplant.(Granulocyte-colony stimulating factor )
November 1, 2000... 2000 NOV 1 - (NewsRx.com) -- Granulocyte-colony stimulating factor (G-CSF) blocks interleukin (IL)-12 production, which inhibits immune recovery after mismatched hematopoietic transplantation, researchers in Italy reported. "One major...

Anti-HIV gp160 (Env) Antibodies Respond to HAART.(Highly active antiretroviral therapy )
November 1, 2000... 2000 NOV 1 - (NewsRx.com) -- Highly active antiretroviral therapy (HAART) may enhance HIV specific humoral immunity by increasing anti-HIV gp160 (Env) antibodies, according to a study from the United Kingdom. "Reconstitution of...

Immuno-Chemotherapy Has Striking Antitumor Effectiveness.
November 1, 2000... 2000 NOV 1 - (NewsRx.com) -- The combination of immunotherapy with chemotherapy induced a strong antileukemic response in murine models, researchers in Poland reported. "Until recently antitumor effects of interleukin (IL)-12 have...

Interferon Treatment Delays MS Development in High-Risk Individuals.(multiple sclerosis )
November 1, 2000... 2000 NOV 1 - (NewsRx.com) -- Early treatment with the multiple sclerosis (MS) therapy interferon beta-1a, or Avonex(r), can significantly reduce the rate at which individuals at high risk for the disease actually develop clinically...

Alloimmunization with Paternal Mononuclear Cells is Successful.
November 1, 2000... 2000 NOV 1 - (NewsRx.com) -- Alloimmunization with paternal mononuclear cells can be used to successfully treat recurrent spontaneous abortion (RSA), finds a study from Argentina. "Alloimmunization as a treatment for RSA is still...

Methacholine Useful in Diagnosis.
November 1, 2000... 2000 NOV 1 - (NewsRx.com) -- Patients with allergic and nonallergic rhinitis show a pronounced increase in nasal sensitivity following exposure to methacholine, making that substance useful in the rhinitis diagnosis, according to...

Corticosteroids Do Not Increase Effectiveness of Antibiotics.
November 1, 2000... 2000 NOV 1 - (NewsRx.com) -- Combining antibiotic therapy for recurrent sinusitis with corticosteroids does not appear to confer a significant increase in treatment benefits. "Emerging evidence indicates that medically recalcitrant...

SIVmac251-Derived Vector Transduces Human Dendritic Cells.
November 1, 2000... 2000 NOV 1 - (NewsRx.com) -- Lentiviral vectors derived from simian immunodeficiency virus (SIV) can transduce human dendritic cells (DCs), report researchers in France. "Lentivirus-derived vectors are very promising gene delivery...

Unique Collaborative Service Established for Childhood Allergy-Related Anaphylaxis.(collaborative service between the Women's and Children's Hospital, in Adelaide, Australia, the South Australian Department of Education, Training, and Employment (DETE), the Australian Red Cross SA, and St. John's Ambulance)
November 1, 2000... 2000 NOV 1 - (NewsRx.com) -- Studies in preschool and school-aged children have resulted in a new collaborative service between the Women's and Children's Hospital, in Adelaide, Australia, the South Australian Department of Education,...

Patients Sought for Cancer Immunotherapy Study.
November 1, 2000... 2000 NOV 1 - (NewsRx.com) -- The University of California, San Francisco, Comprehensive Cancer Center is enrolling patients for trials to investigate a new treatment for kidney cancer, prostate cancer, and melanoma. The aim of the...

Schering-Plough Corp. Exercises Options to Develop Interferon for Multiple Applications.
November 1, 2000... 2000 NOV 1 - (NewsRx.com) -- Schering-Plough Corp. will develop a novel protein discovered by Human Genome Sciences Inc., known as an interferon, in hopes of commercializing a drug that could fight cancer and other diseases. Even if...

Holistic Treatment Advocated for First "Environmental Epidemic".
November 1, 2000... 2000 NOV 1 - (NewsRx.com) -- According to Mary L. Hardy, MD, director of the Cedars-Sinai Medical Center Integrative Medicine Medical Group, respiratory disease (including sinusitis, environmental asthma, and related conditions) has...

Abciximab Causes Complications in Cardiac Surgery.
November 1, 2000... 2000 NOV 1 - (NewsRx.com) -- Abciximab-treated patients have a higher occurrence of bleeding complications during cardiac surgery, noted researchers in the United States. "Early surgical experience with abciximab and other...

B7.1/IL-12 Gene Transfer Stimulates Immune Response in Melanoma Cells.
November 1, 2000... 2000 NOV 1 - (NewsRx.com) -- Adenovirus-mediated gene transfer of the B7.1 co-stimulatory molecule with the cytokine gene interleukin (IL)-12 results in immunostimulatory responses in melanoma cells, researchers in Canada report. ...

Preclinical Results of Suicide Gene Therapy Approach are Promising.
November 1, 2000... 2000 NOV 1 - (NewsRx.com) -- Researchers in Japan report successful suicide gene therapy/cytokine therapy for carcinomatous peritonitis in animal models. "Carcinomatous peritonitis is characterized by massive malignant ascites, while...

Aventis/Gencell Has Numerous Therapeutic Modalities Under Development.
November 1, 2000... 2000 NOV 1 - (NewsRx.com) -- Aventis/Gencell, a company in the United States, is actively pursuing p53 gene therapy, immunotherapy, and anti-angiogenesis gene therapy modalities against cancer. "Aventis/Gencell has been committed to...

Immuno-Gene Therapy Results Promising in Murine Model.
November 1, 2000... 2000 NOV 1 - (NewsRx.com) -- Transduction of renal cell carcinoma cells with cytokine genes resulted in reduced tumor growth and increased survival in murine models, researchers in Poland reported. "Renal cell cancer is resistant to...

High-Dose Interferon Alfacon-1 Safely Fights Hepatitis C Infection.
November 1, 2000... 2000 NOV 1 - (NewsRx.com) -- Administration of high-dose interferon alfacon-1 (Infergen, Amgen) appears to eliminate hepatitis C virus (HCV) infections in most infected patients without increasing their risk of serious side effects,...

Second Course of Interferon Increases Response Rate in Hepatitis C Relapsers.
November 1, 2000... 2000 NOV 1 - (NewsRx.com) -- Hepatitis C virus (HCV) relapsers could potentially be helped by taking a second dose of interferon therapy, according to medical investigators in Japan. These gastroenterologists say that HCV RNA, which...

Encouraging Results from MUC1/IL-2 Immunotherapy Clinical Trial Reported.
November 8, 2000... 2000 NOV 8 - (NewsRx.com) Results from a clinical trial of MUC1 and interleukin (IL)-2 immunotherapy in breast cancer patients are encouraging. "Polymorphic epithelial mucin, encoded by the MUC1 gene, is present at the apical surface...

Patients with History of Penicillin Allergy Usually Test Negative and Can Use Drug Safely.
November 8, 2000... 2000 NOV 8 - (NewsRx.com) -- Most patients with a history of allergy to penicillin show a negative reaction to a skin test for the drug and can safely use penicillin, according to a pilot study in the October 2000 issue of Chest. The...

Squaric Acid Dibutylester Effective Immunotherapy in Children.
November 8, 2000... 2000 NOV 8 - (NewsRx.com) -- Researchers in Italy have found that squaric acid dibutylester (SADBE) is a safe and effective immunotherapeutic for resistant cutaneous warts in children. "We evaluated the efficacy of SADBE contact...

Gamma-Glutamyl-Containing Peptides Have Potential.
November 8, 2000... 2000 NOV 8 - (NewsRx.com) -- Gamma-glutamyl-containing peptides have immunomodulatory potential, researchers in the United States and Russia reported. "Earlier we described gamma-glutamyl and beta-aspartyl containing peptides that...

BCH-1393 Has Synergistic Anti-Tumor Activity When Combined with Cyclophosphamide.
November 8, 2000... 2000 NOV 8 - (NewsRx.com) -- According to a study from Canada, N,N-dimethylaminopurine pentoxycarbonyl D-arginine (BCH-1393) has synergistic anti-tumor activity when combined with cyclophosphamide. "BCH-1393 is a novel low molecular...

Interleukin-1 Receptor Antagonists Show Promise for Treatment.(otitis media)
November 8, 2000... 2000 NOV 8 - (NewsRx.com) -- Blocking the effects the cytokine interleukin-1 may be useful in the treatment of otitis media, or inflammatory ear infections, researchers say. J.E. Kerschner and colleagues at the Children's Hospital of...

Aerosolized Ribavirin and Immunotherapy Successful Against Pneumona in Myelosuppressed Adults.
November 8, 2000... 2000 NOV 8 - (NewsRx.com) -- Combination therapy with aerosolized ribavirin and immunotherapy is effective against respiratory syncytial virus (RSV) pneumonia in myelosuppressed adults with leukemia, say researchers. "During community...

Remicade Approved for Broader Indication.
November 8, 2000... 2000 NOV 8 - (NewsRx.com) -- Schering-Plough Corp. (SGP), Kenilworth, New Jersey, and Centocor, Inc., Malvern, Pennsylvania, announced that the Committee for Proprietary Medicinal Products (CPMP) of the European Agency for the Evaluation...

FDA Approval Received for CTLA4-Ig Clinical Trial.
November 8, 2000... 2000 NOV 8 - (NewsRx.com) -- Repligen Corp. (RGEN), Needham, Massachusetts, announced it has received approval from the U.S. Food and Drug Administration (FDA) to initiate a Phase II clinical trial with CTLA4-Ig. The trial will...

Early Antiretroviral Treatment Has Immunological Benefits.
November 8, 2000... 2000 NOV 8 - (NewsRx.com) -- Researchers in Spain report that early antiretroviral therapy has immunological benefits for patients with HIV-1 infection. M. Plana and colleagues at the Hospital Clinic in Barcelona investigated "whether...

Experimental Drug Helps Rebuild HIV-Damaged Immune Systems Faster than Antiviral Drugs Alone.
November 8, 2000... 2000 NOV 8 - (NewsRx.com) -- Adding an experimental drug to antiviral therapy may help persons with advanced HIV infection rebuild their immune systems faster than antiviral therapy alone, suggest early results from AIDS Clinical Trials...

HIV-1 Immunogen Fails to Increase Disease-Free Survival for Patients Receiving Antiretroviral Therapy.
November 8, 2000... 2000 NOV 8 - (NewsRx.com) -- Adding HIV-1 Immunogen to unrestricted antiretroviral therapy (ART) does not reduce disease progression among adults infected with HIV, compared to what is achievable by ART alone, according to an article in...

HIV Neutralizing Antibody Binds to HIV-1 Envelope Peptide.
November 8, 2000... 2000 NOV 8 - (NewsRx.com) -- Certain peptides may help in the design of anti-HIV immunogens, according to researchers in the United States. "The human monoclonal antibody 2F5 (MAb 2F5) binds to a linear B-cell peptide epitope from the...

Dendritic Cells Mediate Protective Antiviral and Antitumor Immunity.
November 8, 2000... 2000 NOV 8 - (NewsRx.com) -- According to a study from Switzerland, activation of dendritic cells (DC) by a liposomal peptide vaccine induced antiviral and antitumor protection in vivo. "Initiation of antiviral and antitumor T-cell...

Patent Issued for Monoclonal Antibodies to Prostate-Specific Membrane Antigen.
November 8, 2000... 2000 NOV 8 - (NewsRx.com) -- BZL Biologics Inc., New York, New York, announced that Cornell University in New York was issued U.S. Patent No. 6,136,311 entitled "Treatment and Diagnosis of Cancer." BZL holds the exclusive worldwide...

Canadian Patent Position Completed for Zadaxin in Hepatitis C.
November 8, 2000... 2000 NOV 8 - (NewsRx.com) -- SciClone Pharmaceuticals (SCLN), San Mateo, California, announced that it has received an issued patent in Canada for the use of the company's lead drug, Zadaxin, for the treatment of hepatitis C, one of the...

Viral RNA Level is Best Predictor of Response to Interferon.
November 8, 2000... 2000 NOV 8 - (NewsRx.com) -- Hepatitis C virus (HCV) RNA levels can better predict alanine aminotransferase (ALT) normalization after interferon therapy than ALT levels can predict HCV RNA detection, investigators report. Yatian Zhang...

Chemotherapy for Fungal Infection Enhanced by Interferon-Gamma.(systemic cryptococcosis)
November 15, 2000... 2000 NOV 15 - (NewsRx.com) Interferon gamma immunotherapy has been found to enhance the effects of antifungal chemotherapy against systemic cryptococcosis. "The possible enhancement, using immunotherapy with interferon-gamma...

Glucocorticoids Can Prevent Eotaxin-Mediated Inflammation.
November 15, 2000... 2000 NOV 15 - (NewsRx.com) -- Nasally administered glucocorticoids can protect allergic rhinitis sufferers from inflammation caused by nasal eotaxin expression, according to researchers writing in the journal Clinical and Experimental...

Alum Depot Extract Best Compromise Choice For Allergen-Specific Immunotherapy.
November 15, 2000... 2000 NOV 15 - (NewsRx.com) -- Health care professionals using allergen-specific immunotherapy for patients with allergic respiratory problems can safely hedge their bets by using an alum depot extract, according to researchers in Denmark....

Biologic Therapy Safe and Effective in Children.(with Crohn's disease)
November 15, 2000... 2000 NOV 15 - (NewsRx.com) -- Children with active, severe Crohn's disease who had not responded to conventional therapy over four months and had not been able to taper off their potentially growth-stunting steroid therapy, showed...

Remune Monotherapy Safe/Immunotherapeutic in Asymptomatic HIV-1 Patients.
November 15, 2000... 2000 NOV 15 - (NewsRx.com) -- According to results from a clinical trial, Remune monotherapy is safe and has immunomodulating capabilities in asymptomatic HIV-1 infected patients in Thailand. "We examined the effect of a HIV specific...

Human Monoclonal Antibodies Produced in Murine Model are Protective.(against Pseudomonas aeruginosa)
November 15, 2000... 2000 NOV 15 - (NewsRx.com) -- Researchers in the United States have produced human monoclonal antibodies (MAbs) against Pseudomonas aeruginosa (PA) from a transgenic mouse model. The MAbs may be useful as a therapeutic agent against...

Phase II Trial Combines Immunotherapy and Chemotherapy.(for treatment of metastatic renal cell cancer)
November 15, 2000... 2000 NOV 15 - (NewsRx.com) -- Results of a Phase II trial suggest that 5-fluorouracil is not beneficial in combination with recombinant interleukin 2 (rIL-2) and interferon-alpha 2B (IFN-alpha 2B) for the treatment of metastatic renal...

Interleukin-1 Receptor Antagonist May Reduce Progression of Joint Damage.(anakinra may reduce rheumatoid arthritis progression)
November 15, 2000... 2000 NOV 15 - (NewsRx.com) -- Amgen (AMGN) announced that anakinra or interleukin-1 receptor antagonist (IL-1ra), an investigational rheumatoid arthritis (RA) therapy not yet approved by the U.S. Food and Drug Administration, may...

Inhibiting a Specific Enzyme May Lead to Therapy.(for scleroderma)
November 15, 2000... 2000 NOV 15 - (NewsRx.com) -- Blocking the action of a specific enzyme may someday prove to be an effective treatment for scleroderma, a potentially life-threatening disease that results in the overproduction of collagen and which can...

Mayo Clinic Seeks Participants for National Research Study on Peanut Allergy.
November 15, 2000... 2000 NOV 15 - (NewsRx.com) -- Peanut and tree nut allergy can be a serious condition that affects approximately three million Americans. There is no cure for peanut allergy, merely symptomatic relief, and there is a lack of public and...

Effect of Zadaxin on Immune Response of HBV Patients Described.
November 15, 2000... 2000 NOV 15 - (NewsRx.com) -- SciClone Pharmaceuticals (SCLN), San Mateo, California, announced that a study presented at the 51st Annual Meeting of the American Association for the Study of Liver Diseases (AASLD), held in Dallas, Texas,...

Partnership Entered to Develop Antibodies.(Cambridge Antibody Technology and Human Genome Sciences enter partnership)
November 15, 2000... 2000 NOV 15 - (NewsRx.com) -- Cambridge Antibody Technology (CAT), Melbourn, United Kingdom, and Human Genome Sciences (HGSI), Rockville, Maryland, announced that HGS has exercised an option to enter into an exclusive development...

Long-Term Data Presented on Fully Human Anti-TNF Antibody.(tumor necrosis factor)
November 15, 2000... 2000 NOV 15 - (NewsRx.com) -- A study reported at the 64th Annual Scientific Meeting of the American College of Rheumatology, held in Philadelphia, Pennsylvania, during October 2000, suggests that D2E7, the first fully human anti-TNF...

Positive HuMax-CD4 Results Announced.
November 15, 2000... 2000 NOV 15 - (NewsRx.com) -- Genmab A/S (GEN; GE9), Philadelphia, Pennsylvania, announced positive results from a Phase I/II clinical trial of HuMax-CD4, a fully human antibody used to treat patients with rheumatoid arthritis. ...

Benefits of IL-2-Transduced Cells Must Be Balanced By Toxic Complications.(interleukin-2)
November 15, 2000... 2000 NOV 15 - (NewsRx.com) -- According to a study from Austria, the benefits of interleukin (IL)-2-transduced bone marrow cells must be balanced by dose-limiting toxicities. "The purpose of this study was to investigate the effects...

Monoclonal Antibody Enters Phase II Clinical Trials for Breast and Colorectal Cancer.(Seattle Genetics Inc. tests SGN-15)
November 15, 2000... 2000 NOV 15 - (NewsRx.com) -- Seattle Genetics, Inc., announced the initiation of Phase II clinical testing with one of its lead monoclonal antibody drug conjugates, SGN-15. Two Phase II efficacy studies are being conducted, one for...

Grants Received for Research on Central Nervous System Repair.(Acorda Therapeutics awarded grant)
November 15, 2000... 2000 NOV 15 - (NewsRx.com) -- Acorda Therapeutics, Hawthorne, New York, announced that it has been awarded a Phase I Small Business Innovation Research (SBIR) grant and a Phase I Small Business Technology Transfer Grant (STTR) by the U.S....

B7 Co-Stimulatory Requirements Differ According to Vaccine Type.
November 15, 2000... 2000 NOV 15 - (NewsRx.com) -- Requirements for B7 co-stimulation differ according to whether the vaccine is a DNA vaccine, a protein vaccine, or a recombinant poxvirus vaccine, a recent study indicates. "Whether B7-1 and B7-2 have...

Novel Interleukin Identified that Plays Key Role in Immune System Regulation.(interleukin 21 and interleukin 21 receptor)
November 15, 2000... 2000 NOV 15 - (NewsRx.com) -- Building on a rapidly growing body of research in the field of immunology, scientists at ZymoGenetics, Inc., have identified the interaction of two proteins that appear to play a key role in the human body's...

Immunotherapeutic Suppresses Hepatitis-B-Associated Cancer in Mice.(Enzo Biochem Inc.'s EHT899)
November 15, 2000... 2000 NOV 15 - (NewsRx.com) -- Enzo Biochem, Inc., (ENZ), reported that in preclinical animal studies of the company's proprietary immune regulation product, EHT899, researchers in Israel had achieved complete suppression of HBV-associated...

Liposomal Vaccine is Immunotherapeutic at Higher Dose.
November 15, 2000... 2000 NOV 15 - (NewsRx.com) -- A liposomal vaccine targeting the MUC1 peptide stimulated immune responses in non-small cell lung cancer (NSCLC) patients enrolled in a Phase I study. "A liposomal formulation of a 25-amino acid MUC1...

Phase I Results Announced with SMART Anti-Gamma Interferon Antibody.
November 15, 2000... 2000 NOV 15 - (NewsRx.com) -- Protein Design Labs, Inc. (PDL) (PDLI), Fremont, California, announced the presentation of Phase I clinical results with its investigational drug SMART Anti-Gamma Interferon Antibody at the 64th Annual...

Monoclonal Antibody Reduces Hospitalization Rates, Costs for High-Risk Infants.(Synagis)
November 15, 2000... 2000 NOV 15 - (NewsRx.com) -- MedImmune, Inc. (MEDI), Gaithersburg, Maryland, announced that data from studies with Synagis (palivizumab) were presented at the 2000 Annual Meeting of the American Academy of Pediatrics (AAP), held in...

Interim Combination Monoclonal Antibody Therapy Data Presented.
November 15, 2000... 2000 NOV 15 - (NewsRx.com) -- XTL Biopharmaceuticals Ltd. (XTL), Rehovot, Israel, presented promising data on the antiviral activity and safety of HBV-AbsXTL (XTL-001) from a Phase I trial in chronic hepatitis B virus (HBV) infected...

Cancer Vaccine Stimulates Tumor-Specific Immune Responses.
November 22, 2000... 2000 NOV 22 - (NewsRx.com) -- Clinical trial data show that vaccination of patients with recurrent malignant astrocytoma with autologous tumor cells and granulocyte-macrophage colony-stimulating factor (GM-CSF) stimulate immune responses,...

Biologic Therapy Safe, Effective in Children with Persistent, Severe Disease.(Crohn's disease)
November 22, 2000... 2000 NOV 22 - (NewsRx.com) -- Children with active, severe Crohn's disease, who had not responded to conventional therapy over four months and had not been able to taper off their potentially growth-stunting steroid therapy, showed...

Natural Killer Cells Benefit Allogenic Bone Marrow Transplantation.
November 22, 2000... 2000 NOV 22 - (NewsRx.com) -- Adoptive immunotherapy with natural killer (NK) cells may be a useful adjunct for patients undergoing allogenic bone marrow transplantation (BMT), suggest researchers in the United States. "BMT has been...

Two Major Allergens Identified in Timothy Grass Pollen.
November 22, 2000... 2000 NOV 22 - (NewsRx.com) -- According to a study from Germany, pollen of timothy grass (Phleum pratense) has two major allergens that affect people. "More than 70% of the patients allergic to grass pollen exhibit immunoglobulin E...

High Paracetamol Use Link Found.(acetaminophen use may be linked with asthma and allergic disease prevalence)
November 22, 2000... 2000 NOV 22 - (NewsRx.com) -- A high usage of paracetamol (acetaminophem) might partly explain why the prevalence of asthma and other allergic diseases is higher in some countries than others, according to research published in the...

Combination Chemo/Immunotherapy Evaluated in Metastatic Disease.
November 22, 2000... 2000 NOV 22 - (NewsRx.com) -- Pilot trial data from a combined modality high-dose chemotherapy regimen with stem cell transplantation and adoptive immunotherapy for breast cancer are encouraging. "We have previously demonstrated that...

Study: C6/Wistar Rat Glioma Model Inappropriate for Evaluating Responses.
November 22, 2000... 2000 NOV 22 - (NewsRx.com) -- According to a study from the United States, the C6/Wistar rat intracranial model may be inappropriate for evaluating immunotherapy protocols as it is allogenic. "Intracranial rat glioma models are a...

Unexpected Cytokines Involved in Mediation.
November 22, 2000... 2000 NOV 22 - (NewsRx.com) -- The mechanisms that cause the symptoms of seasonal allergic rhinitis or hay fever may be at variance with conventional medical thought, according to researchers writing in the Journal of Allergy and Clinical...

Study Finds Brain Activity Affects Immune System.
November 22, 2000... 2000 NOV 22 - (NewsRx.com) -- Next time you feel a little under the weather, try a novel way to boost your immune system - play contract bridge. In a presentation at the annual meeting of the Society for Neuroscience, held November...

Basiliximab Immunosuppression Beneficial to Children.
November 22, 2000... 2000 NOV 22 - (NewsRx.com) -- The use of basiliximab (BX) combined with low-dose calcineurin inhibitors reduces nephrotoxicity complications in children after liver transplantation, researchers in the United Kingdom reported. "Liver...

Virulizin Results Presented.
November 22, 2000... 2000 NOV 22 - (NewsRx.com) -- Lorus Therapeutics Inc. (LORFF; LOR.) reported that the positive results of Phase II clinical trials for its lead anti-cancer drug Virulizin(R) were presented at the 23rd Chemotherapy Foundation Symposium,...

Fully Human Antibodies to be Developed.
November 22, 2000... 2000 NOV 22 - (NewsRx.com) -- Medarex, Inc. (MEDX), Princeton, New Jersey, and Eli Lilly and Company (LLY), Indianapolis, Indiana, announced that Medarex has agreed to produce fully human antibodies for a number of Lilly disease targets....

Heat Shock Protein Immunotherapy Data Presented.
November 22, 2000... 2000 NOV 22 - (NewsRx.com) -- Stressgen Biotechnologies Corp. (SSB) announced the presentation of preclinical data on the immune response to the HspE7 fusion protein at the International Symposium on Heat Shock Proteins in Biology and...