Immunotherapy Weekly articles from November 1998

Immunotherapy Weekly archives from November 1998

Adoptive Immunotherapy Fails to Clear Virus Infection in B-Cell-Deficient Mice.
November 2, 1998... A murine model pointed to an expanded role for B cells in the development and maintenance of CD4 and CD8 T-cell functions. Cytotoxic T lymphocytes (CTL) are associated with the clearance of both acute and chronic viral infections. A...

Cancer Immunology: Suppression of IL-8 in Certain Cancers Affects Autocrine Growth Factors.
November 2, 1998... Antisense suppression of interleukin-8 (IL-8) in liver and pancreatic cancer cells suggests that IL-8 functions as an autocrine growth factor and influences tumorigenicity. In previous research M. Miyamoto and colleagues from the Toyama...

Cancer Immunotherapy: CD40/CD40L Interaction Helps Generate Enhanced CTL Activity.
November 2, 1998... CD40/CD40L interaction with cytokines is important for the generation of cytotoxic T lymphocytes (CTL) against cancer cells. In previous research, T.V. Kalinichenko et al. demonstrated the importance of B7-2 expression for the enhanced...

Cancer Immunotherapy: IL-2 Stimulates Signal Transducers and Activators of Transcription.
November 2, 1998... Interleukin-2 (IL-2) administration stimulates signal transducers and activators of transcription (STAT) in cancer patients. C.M. Nicolet and colleagues from the University of Wisconsin, reported an analysis of the transcription factor...

Immunology: Anti-Adhesion Molecule Therapy May Be Useful After Acute Stroke.
November 2, 1998... Anti-adhesion molecule therapy may help prevent secondary inflammatory mechanisms after the onset of acute stroke. Increasing evidence suggests that inflammatory mechanisms contribute to secondary neuronal injury after acute cerebral...

Bone Marrow Transplantation: CD34+ Cells Is Associated with Rapid Engraftment.
November 2, 1998... Allogeneic transplantation of CD34(+) cells is associated with rapid engraftment and few cases of severe graft-versus-host disease. A. Urbanoispizua et al. performed a study to analyze CD34(+) cell recovery and T cell depletion (TCD)...

Immunology: Deviation from Th1 to Th2 Response Does Not Blunt T cell-Dependent Responses.
November 2, 1998... Treating islet allograft recipient mice with anti-interleukin-12 (IL-12) monoclonal antibody (mAb) effectively produced Th1 to Th2 immune deviation, however it did not prolong engraftment of major histocompatibility complex (MHC)-mismatched...

Immunology: Stress Lowers Cancer-Fighting Ability Among Those Who Need It Most.
November 2, 1998... Chronic stress may reduce the activity of cancer-fighting natural killer (NK) cells in the immune systems of those already predisposed to cancer, according to a study. Among people who cared for spouses with Alzheimer's disease, those with...

Industry News: Diagnostic Test Patented for Cognitive Disorder.
November 2, 1998... Hemispherx Biopharma, Inc., New York, announced that it received Notice of Allowance from the U.S. Patent Office of a patent application entitled "Diagnosis and Treatment of Neuro-cognitive Disorders Associated with Systematic Immunological...

Arthritis Gene Therapy: "Direct In Vivo Transfer of the IL-1Ra Gene In Osteoarthritic Rabbit Knee Joints: Prevention of the Disease Progression.".
November 2, 1998... J.-P. Pelletier, J.C. Fernandes, G. Tardif, V. Lascau-Coman, M. Dupuis and J. Martel-Pelletier. Osteoarthritis Research Unit, Centre de recherche L-C. Simard, CHUM-Campus Notre-Dame, Montreal, Quebec, Canada. According to an abstract...

Arthritis Immunotherapy: "Effects of Intraarticular Injection of Angiogenesis Inhibitor TNP-470 On Collagen-Induced Arthritis.".
November 2, 1998... K.J. Kim, M. Iwase and Y. Kobayashi and T. Itoh. Department of Orthopedic Surgery, Tokyo Women's Medical College, Shinjubu, Tokyo, Japan. According to an abstract submitted by the authors to the 62nd Annual Meeting of the American...

Mucosal Vaccines: "Local and Disseminated IgA Antibody Responses after Intravaginal or Intranasal Immunization: Possible Role of a Mucosal Immune Inductive Site.".
November 2, 1998... H.-Y. Wu, S. Abdu, and M.W. Russell. Univ. of Alabama at Birmingham, Birmingham, Alabama. According to an abstract submitted by the authors to the 38th Interscience Conference on Antimicrobial Agents and Chemotherapy, held September...

Cancer Immunology: "Tumor Immunity and Autoimmunity Induced by Immunization with Homologous DNA.".
November 2, 1998... Journal of Clinical Investigation, September 15, 1998;102(6):1258-1264. Weber, L.W.; Bowne, W.B.; Wolchok, J.D.; Srinivasan, R.; Qin, J.; Moroi, Y.; Clynes, R.; Song, P.; Lewis, J.J.; Houghton, A.N. According to the authors' abstract of...

Cancer Immunotherapy: "Enhanced Antitumour Effect of Liposomal Daunorubicin Using Antibody-Phospholipase C Conjugates or Fusion Protein.".
November 2, 1998... International Journal of Oncology, October 1998;13(4):819-825. Carter, G.; White, P.; Fernie, M.; King, S.; Mclean, G.; Titball, R.; Carr, F.J. According to the authors' abstract of an article published in International Journal of...

Drug Development: "Preclinical Antitumor Efficacy of S-1: A New Oral Formulation of 5-fluorouracil on Human Tumor Xenografts.".
November 2, 1998... International Journal of Oncology, October 1998;13(4):693-698. Fukushima, M.; Satake, H.; Uchida, J.; Shimamoto, Y.; Kato, T.; Takechi, T.; Okabe, H.; Fujioka, A.; Nakano, K.; Ohshimo, H.; Takeda, S.; Shirasaka, T. According to the...

Cancer Immunotherapy: IL-2 Mediates Durable Responses in Metastatic Cancer Patients.
November 2, 1998... High-dose interleukin-2 (IL-2) mediated durable therapeutic responses in patients with metastatic melanoma or renal cancer. S.A. Rosenberg and colleagues from the U.S. National Cancer Institute initiated a study to determine the durability...

Cystic Fibrosis Drug Reverses Osteoporosis after Transplants in CF Patients.
November 2, 1998... Studies of a drug known as Pamidronate indicate that the drug is effective in partially reversing osteoporosis due to drugs taken after various transplantation procedures, including lung transplants in cystic fibrosis patients. The...

Arthritis Gene Therapy: "Adenovector-Mediated Gene Transfer of Active Transforming Growth Factor-(beta)1 in the Murine Knee Joint Induces Fibrosis and Osteophyte Formation.".
November 2, 1998... A.C. Bakker, H.M. van Beuningen, P. van Lent, P.M. van der Kraan, C.D. Richards, F.A.J. van de Loo and W.B. van den Berg. Department of Rheumatology, University Hospital Nijmegen, The Netherlands; Department of Pathology, McMaster University,...

Immunology (TB): "Immunomodulating Effects of CRL-1072 in Human U937 Macrophages.".
November 2, 1998... C. Jagannath, J.K. Actor, C. Leonard and R.L. Hunter Jr. University of Texas at Houston Medical School, Houston, Texas. According to an abstract submitted by the authors to the 38th Interscience Conference on Antimicrobial Agents and...

Pathogenesis (Alzheimer's Disease): "Amyloid Precursor Protein (APP) mRNA is Stabilized in Vitro by hnRNP C and Nucleolin.".
November 2, 1998... L. Rajagopalan, C. Westmark, J. Jarzembowski and J.S. Malter. Department of Pathology, University of Wisconsin Medical School, Madison, Wisconsin. According to an abstract submitted by the authors to the Annual Meeting of the Association...

Drug Development: "Effects of New Triphenylethylene Platinum(II) Complexes on the Interaction with Phosphatidylcholine Liposomes.".
November 2, 1998... Chemical & Pharmaceutical Bulletin, September 1998;46(9):1480-1483. Grenier, G.; Berube, G.; Gicquaud, C. According to the authors' abstract of an article published in Chemical & Pharmaceutical Bulletin, "In a previous work, we...

Cancer Immunotherapy: GM-CSF and CD80 Gene-Transduction Cooperate in Antitumor Immunity.
November 9, 1998... When murine hematopoietic tumor cells, which have been transduced with either granulocyte-macrophage colony-stimulating factor (GM-CSF) or CD80 genes, are inoculated together as a vaccine, they cooperate to enhance antitumor immunity. ...

Cancer Immunotherapy: Certain Cancer Antigens are Attractive Targets for Specific Immunotherapy.
November 9, 1998... Testing reveals that five melanoma antigens should make attractive targets for specific anti-cancer immunotherapy. N. Labarriere and colleagues from the Inserm Institute of Biology, Nantes, France, expanded research on several tumor...

Cancer Immunotherapy: IL-12, IL-15 have Synergistic Immune-Modulating Effect In Vitro.
November 9, 1998... The combined administration of interleukin (IL)-12 and IL-15 may be less toxic and just as useful as anti-cancer immunotherapy with IL-2 alone. The cytokines IL-2 and IL-12 modify the functional status of T- and natural killer (NK) cells...

Cancer Immunotherapy: OK-432 Stimulates Immune Responses From Lymph Node Cells of Cancer Patients.
November 9, 1998... OK-432 stimulates cytotoxic T lymphocyte (CTL) and lymphokine-activated killer (LAK) cell activity in mononuclear cells from the regional lymph nodes of lung cancer patients. K. Takahashi and colleagues from the University of Tokushima,...

Cytokine Gene Transfer Targeting Circulating IL-5 May Be Therapeutic for Asthmatics.
November 9, 1998... Strategies that target circulating interleukin (IL)-5 and/or its receptors may have a place in the treatment of allergic airways eosinophilic inflammation. J. Wang and colleagues from the McMaster University in Hamilton, Ontario, Canada,...

Immunopathology Anti-TNF(alpha) Products Have Therapeutic Merit in the Treatment of Crohn's Di.
November 9, 1998... Specific cytokine-directed therapy may have a role in the treatment of Crohn's disease. Tumor necrosis factor-alpha (TNF(alpha)) is thought to play a central role in the immunopathology of Crohn's disease. Particularly as the levels of...

AIDS Therapies Anticholesterol Drug Restores PBMC Immune Responses.
November 9, 1998... In vitro experiments suggest that AIDS therapies may be enhanced by immunorestorative drugs. The studies showed that an anticholesterol drug could restore normal in vitro proliferative and cytokine responses to peripheral blood mononuclear...

PBPC Transplantation Underlying Clinical Characteristics Influence Sustained Engraftment.
November 9, 1998... Some patients with poor platelet engraftment may be candidates for newly developed cytokine therapies, researchers indicated. Although much data has been published that documents variables associated with early platelet engraftment after...

Therapy (HCV) Leukocyte IFN-(alpha) Useful in Dialysis Patients.
November 9, 1998... Low-dose leukocyte interferon-alpha therapy is useful in the treatment of patients with chronic hepatitis C who are on dialysis. Kidney failure is a contraindication to interferon therapy, and active chronic hepatitis is incompatible with...

Therapy (TB): Aerosolized IFN-(alpha) May Advance Tuberculosis Treatment.
November 9, 1998... Aerosolized interferon-alpha may be a beneficial addition to therapy for patients with pulmonary tuberculosis. Researchers from Italy's Istituto Lazzaro Spallanzani found that adding interferon to standard therapeutic protocols resulted in...

Immunology Enhanced Method for Inducing Mucosal Immune Responses Reported.
November 9, 1998... CpG ImmunoPharmaceuticals, Inc., Wellesley, Massachusetts, researchers have demonstrated the ability of CpG DNA to stimulate potent immune responses in animal models when administered as part of a mucosal vaccine. A research study...

Industry News (Patents and Technology): Antigen-Specific T-Cell Expansion Broad Patent Issuance Announced.
November 9, 1998... Fred Hutchinson Cancer Research Center, Seattle, Washington, and Targeted Genetics Corp. announced that they have received notification from the U.S. Patent and Trademark Office regarding the issuance of a patent entitled, "Rapid Expansion...

Industry News (Patents and Technology): U.S. Patent Received for Transgenic Antibody Production.
November 9, 1998... Genzyme Transgenics Corp., Framingham, Massachusetts, was granted a U.S. patent entitled, "Transgenic Production of Antibodies in Milk" by the U.S. Patent and Trademark Office. The patent grants Genzyme Transgenics exclusive rights to the...

Immuno-Stimulation "Activation of Antigen Presenting Cells (APCs) by Immuno-Stimulatory DNA Sequences (ISS).".
November 9, 1998... H. Kobayashi, E. Martin-Oroxco, J. Van Uden and E. Raz. Department of Medicine, University of California, San Diego, La Jolla, California. According to an abstract submitted by the authors to the 62nd Annual Meeting of the American College...

Alveolar Echinococcosis: "Towards an Immunotherapy of Alveolar Echinococcosis?".
November 9, 1998... L. Jenne, J. Kilwinski, W. Flick and P. Kern. Department of Immunology, University Hospital, Geneve, Switzerland; Department of Infectious Diseases and Clinical Immunology, University Hospital, Ulm, Germany. According to an abstract...

DNA Vaccines: "Assessment of Interferon-gamma Producing Cells By Elispot After Immunization of Humans with a PFCSP DNA Vaccine.".
November 9, 1998... M. Sedegah, R. Wang, D.L. Doolan, T. Le, R. Hedstrom, T.R. Jones, J.A. Tine, P. Hobart, A. Malik-Kumar and S.L. Hoffman. Malaria Program, Naval Medical Research Institute, Bethesda, Maryland; Virogenetics Corporation, Troy, New York; Vical,...

Gender Differences: "Gender Differences in Inhibition of Human Whole Blood Lymphocyte Proliferation and Interactions Between Calcium Channel Blockers and Immunosuppressants.".
November 9, 1998... F.-S. Chow and W.J. Jusko. Department of Pharmaceutics, State University of New York at Buffalo, Buffalo, New York. According to an abstract submitted by the authors to the 1998 Annual Meeting of the American Association of Pharmaceutical...

Gender Influences: "Influence of Gender on Prednisolone Effects on Whole Blood T-Cell Deactivation and Trafficking in Rats.".
November 9, 1998... G.M.L. Meno-Tetang, J.V.S. Gobburu and W.J. Jusko. Wyeth-Ayerst Research, Pearl River, New York; Center for Drug Development Science, Washington, DC; School of Pharmacy, State University of New York at Buffalo, Buffalo, New York. ...

Cancer Immunotherapy: "Expression of Signal Transducing T-Cell Receptor zeta Molecules After Adoptive Immunotherapy in Patients with Gastric and Colon Cancer.".
November 9, 1998... International Journal of Cancer, October 29, 1998;78(3):301-305. Kono, K.; Ichihara, F.; Iizuka, H.; Sekikawa, T.; Matsumoto, Y. According to the authors' abstract of an article published in International Journal of Cancer, "We and others...

Cancer Therapy "Inhibition of Human Telomerase by 2'-O-methyl-RNA.".
November 9, 1998... Proceedings of the National Academy of Sciences of the United States of America, September 29, 1998;95(20):11549-11554. Pitts, A.E.; Corey, D.R. According to the authors' abstract of an article published in Proceedings of the National...

Malaria (Therapy): "Quinine and Mefloquine in the Treatment of Multidrug-Resistant Plasmodium falciparum Malaria in Pregnancy.".
November 9, 1998... Annals of Tropical Medicine and Parasitology, September 1998;92(6):643-653. Mcgready, R.; Cho, T.; Hkirijaroen, L.; Simpson, J.; Chongsuphajaisiddhi, T.; White, N.J.; Nosten, F. According to the authors' abstract of an article...

Psoriasis: "The Antipsoriatic Agent Dimethylfumarate Immunomodulates T-Cell Cytokine Secretion and Inhibits Cytokines of the Psoriatic Cytokine Network.".
November 9, 1998... British Journal of Dermatology, September 1998;139(3):390-395. Ockenfels, H.M.; Schultewolter, T.; Ockenfels, G.; Funk, R.; Goos, M. According to the authors' abstract of an article published in British Journal of Dermatology, "Interactions...

Skin Disease: "Discovery of Ascomycin Analogs with Potent Topical But Weak Systemic Activity for Treatment of Inflammatory Skin Diseases.".
November 9, 1998... Current Pharmaceutical Design, October 1998;4(5):367-379. Mollison, K.W.; Fey, T.A.; Gauvin, D.M.; Sheets, M.P.; Smith, M.L.; Pong, M.; Krause, R.; Miller, L.; Or, Y.S.; Kawai, M.; Wagner, R.; Wiedeman, P.E.; Clark, R.F.; Gunawardana, I.W.K.;...

Genetic Immunization Dendritic Cell Targeting Enhances Vaccination.
November 23, 1998... Dendritic cells play an important role in controlling and augmenting the immunological outcome of genetic immunization. Gene vaccines have several advantages over live/attenuated or protein subunit vaccines. These advantages include...

Allergy Immunotherapy Pathogenesis Research Suggests Immunotherapy Opportunities.
November 23, 1998... A better understanding of the pathogenesis involved in allergic reactions paves the way for creating potential immunotherapeutics for this disease. French researchers H. Dalens et al. studied vernal keratoconjunctivitis in a population of...

Autoimmune Gene Therapy Engineered T Cells Target Allergic Encephalomyelitis.
November 23, 1998... T cells genetically engineered to express latent transforming growth factor-beta 1 (TGF-beta 1) may be useful in the therapy of autoimmune diseases. L.Z. Chen and colleagues from the New York University School of Medicine researched gene...

Cancer Immunotherapy Autologous Melanoma Cell Vaccine Generates Immunity.
November 23, 1998... A phase I clinical trial demonstrated that vaccination with irradiated autologous melanoma cells engineered to secrete human granulocyte-macrophage colony-stimulating factor (GM-CSF) was capable of generating a potent antitumor immunity in...

Cancer Immunotherapy Chromosomal Aberrations Responsible for Failed Therapy.
November 23, 1998... Genetic analysis explains the pathogenesis of failed cancer immunotherapy. Research based on conventional cytogenetic studies of tumor cells from patients with breast or ovarian cancer have shown multiple chromosomal abnormalities...

Cancer Immunotherapy Study Explores Pathogenesis of Renal Cancer Immunotherapy.
November 23, 1998... Proinflammatory cytokines IFN-gamma and TNF-alpha play a critical role in the successful treatment of renal cancer by immunotherapy. Research has demonstrated that mice bearing the experimental murine renal cancer Renca can be successfully...

Immunomodulation (HIV) Prostaglandin E-2 Affects HIV-1 Transcription.
November 23, 1998... Prostaglandin E-2 (PGE(2)) induces signaling events that affect the pathogenesis of HIV-1 infection. Canadian researchers from the University of Quebec explored the interactions of PGE(2) on viral and host cellular factors of HIV-1...

Conference Coverage (AASLD) HCV+ African-Americans Respond Poorly to IFN.
November 23, 1998... Two surprising studies find that African-Americans have a poorer response to hepatitis C virus therapy than other ethnic groups. One study suggests that interferon is less effective in African-Americans than in other groups even after...

Conference Coverage (AASLD) Pegylated IFN May Offer Advantage Over Standard Treatment.
November 23, 1998... A longer lasting form of interferon alpha-2a may offer a significant advantage over standard interferon therapy for the treatment of chronic hepatitis C. Pegylated 40K-interferon alpha-2a (Hoffmann-La Roche) was shown to be far more...

Hematopoietic Stem Cells Marrow Cells Transduced with MDR1 Vector Enables Stem Cell Expansion.
November 23, 1998... While it is possible to expand MDR1 stem cells in vitro using hematopoietic cytokines, enforced stem-cell self-renewal divisions can have detrimental consequences. Efforts to expand repopulating hematopoietic cells ex vivo have produced...

Immunology Age-Related Changes Should Be Considered When Evaluating Children's Immune Status.
November 23, 1998... Age-related changes need to be considered along with other factors when evaluating the immune status of children. This is because among children, lymphocyte subsets vary significantly with age. Using flow cytometry, S. Shahabuddin and...

Immunology (TB) Heterologous Immunity and BCG Studied.
November 23, 1998... Researchers from the London School of Infectious and Tropical Diseases report the effect of heterologous immunity on the efficacy of bacillus Calmette-Guerin vaccine. Exposure of populations to microbes which share antigens with pathogens...

Monoclonal Antibodies Immune Therapy May Stop Septic Shock.
November 23, 1998... Monoclonal antibodies (MAbs) to a cellular receptor dramatically rescued rabbits from otherwise lethal septic shock. Septic shock can result in organ failure and severe injury following infection with gram-negative (GN) bacteria. It is...

Immunology Study Discovers Apparent Natural Immunity to Cancer.
November 23, 1998... Scientists said they had seen for the first time how the body can fight off cancer naturally - a discovery they said could lead to ways of battling the disease. They found T cells that can kill cancer cells. Doctors had suspected such T...

Melanoma (Immunotherapy) Scientists Spot Cancer-Killing Cells in Patients.
November 23, 1998... Scientists have identified killer cells in the immune system of skin cancer patients that can recognize and attack the disease, they said. The discovery of the killer cells, known as cytotoxic T lymphocytes, represents a valuable tool for...

Arthritis Gene Therapy "Autologous Fibroblasts as Vector Cells for Anti-Inflammatory Gene Transfer Collagen Arthritis.".
November 23, 1998... N. Bessis, C. Fournier and M.C. Boissier. Groupe de Recherche en Immunopathologie et Immunointervention, Universite Paris-Nord, Bobigny; INSERM U 477, Universite Rene Descartes, Paris; Department de Rhumatologie, CHU Avicenne, Bobigny, France....

Arthritis Immunotherapy "Adeno-Associated Virus (AAV) Production of sTNF and IL1-RA Neutralizes TNAa and IL-1 and Reduces Collagen Induced Arthritis.".
November 23, 1998... H.-G. Zhang, T. Zhou, C.K. Edwards, W.R. Rich and J.D. Mountz. Amgen, Inc., Thousand Oaks, California; University of Alabama at Birmingham. According to an abstract submitted by the authors to the 62nd Annual Meeting of the American...

DNA Vaccines "Manipulation of the Immune Phenotype Following DNA Vaccination.".
November 23, 1998... M. Corr, A. von Damm, D.J. Lee and D.A. Carson. Department of Medicine, University of California at San Diego and The Sam and Rose Stein Institute for Aging, La Jolla, California. According to an abstract submitted by the authors to the...

Immunogenicity (Vaccines) "Immunization of Rabbits With Short Synthetic B-Cell Epitopes of Human La/SSB Autoantigen Elicits Specific B and T Cell Responses Against La/SSB.".
November 23, 1998... A.G. Tzioufas, E.E. Yiannaki, P.G. Vlachoyiannopoulos, M.N. Manoussakis, M. Sakarellos-Daitsiotis, C. Sakarellos and H.M. Moutsopoulos. University of Athens, Athens, Greece; University of Ioannina, Greece. According to an abstract...

Immunosuppression "Organ Transplant Immunosuppression Without Bone Loss.".
November 23, 1998... G.R. Goodman, I.R. Dissanayake, B.R. Sodam, E. Gorodetsky, J. Lu, Y.F. Ma, W.S. Jee and S. Epstein. Albert Einstein Medical Center, Philadelphia, Pennsylvania; Allegheny University of Health Science-MCP, Philadelphia, Pennsylvania;...

Dermatology "Successful Treatment of Disseminated Facial Verrucae with Contact Immunotherapy.".
November 23, 1998... European Journal of Dermatology, October-November 1998;8(7):488-491. Weisshaar, E.; Neumann, H.J.; Gollnick, H. According to the authors' abstract of an article published in European Journal of Dermatology, "Disseminated flat warts are a...

Immunology "Tumor Defense by Murine Cytotoxic T Cells Specific for Peptide Bound to Nonclassical MHC Class I." Cancer Research, October 15, 1998;58(20):4682-4687.
November 23, 1998... Griffiths, E.; Ong, H.; Soloski, M.J.; Bachmann, M.F.; Ohashi, P.S.; Speiser, D.E. According to the authors' abstract of an article published in Cancer Research, "Cytotoxic T cells (CTLs) can exhibit considerable antitumor activity. Thus far,...

Immunotherapy "Use of Tacrolimus Eliminates Acute Rejection as a Major Complication Following Simultaneous Kidney and Pancreas Transplantation." Clinical Transplantation, October 1998;12(5):401-405.
November 23, 1998... Peddi, V.R.; Kamath, S.; Munda, R.; Demmy, A.M.; Alexander, J.W.; First, M.R. According to the authors' abstract of an article published in Clinical Transplantation, "This retrospective study illustrates the efficacy of tacrolimus-based...

Malaria (Drug Resistance) "Plasmodium falciparum Resistance to Mefloquine, Chloroquine, and Cycloguanil and Prevention of Malaria in Travellers from France to Africa." Presse Medicale, September 26, 1998;27(28):1419-1423.
November 23, 1998... Lebras, J.; Durand, R.; Dipiazza, J.P.; Pradines, B.; Longuet, C.; Parzy, D. According to the authors' abstract of an article published in Presse Medicale, "OBJECTIVES: Assess the efficacy of preventive and curative treatments of imported...

Monoclonal Antibodies "Enhancement of Cell-Mediated Immunity in Melanoma Patients Immunized with Murine Anti-Idiotypic Monoclonal Antibodies (MELIMMUNE(R)) That Mimic the High Molecular Weight Proteoglycan Antigen.".
November 23, 1998... Clinical Cancer Research, October 1998;4(10):2363-2370. Pride, M.W.; Shuey, S.; Grillolopez, A.; Braslawsky, O.; Ross, M.; Legha, S.S.; Eton, O.; Buzaid, A.; Ioannides, C.; Murray, J.L. According to the authors' abstract of an article...

Mucosal Immunization "Increase in Plasma Viral Load After Oral Cholera Immunization of HIV Infected Subjects." AIDS, October 1, 1998;12(14):F145-F150.
November 23, 1998... Ortigaodeosampaio, M.B.; Shattock, R.J.; Hayes, P.; Griffin, G.E.; Linharesdecarvalho, M.I.; Deleon, A.P.; Lewis, D.J.M.; Castellobranco, R.R. According to the authors' abstract of an article published in AIDS, "OBJECTIVE: Constant...

Pancreatitis "Evaluation of the Immunomodulatory Effect of Gabexate Mesilate in Patients with Severe Acute Pancreatitis." Current Therapeutic Research - Clinical and Experimental, October 1998;59(10):710-716.
November 23, 1998... Pezzilli, R.; Barakat, B.; Morsellilabate, A.M. According to the authors' abstract of an article published in Current Therapeutic Research - Clinical and Experimental, "Gabexate mesilate, a potent serine proteinase inhibitor, has been...

Tuberculosis (Drug Resistance) "Drug-Resistant Pulmonary Tuberculosis in the Baja California-San Diego County Border Population." Western Journal of Medicine, October 1998;169(4):208-213.
November 23, 1998... Peter, C.R.; Schultz, E.; Moser, K.; Cox, M.; Freeman, R.; Ramirezzetina, M.; Lomeli, M.R. According to the authors' abstract of an article published in Western Journal of Medicine, "A study was conducted to determine the frequency of, and risk...

HIV Immunotherapy Alloantigen Stimulation Induces Anti-HIV-1 Responses.
November 30, 1998... Alloantigen stimulation of peripheral blood mononuclear cells (PBMC) from healthy HIV negative donors produces soluble factors that inhibit HIV replication. Several studies have suggested that an immune response to human leukocyte antigen...

Cancer Gene Therapy Oral DNA Vaccination Provides Antitumor Immunity.
November 30, 1998... Oral DNA vaccination with a bacterial carrier induced cell-mediated and systemic humoral immune responses in a murine fibrosarcoma model. Effective anti-cancer vaccines need to deliver antigen-encoding DNA specifically to antigen-presenting...

Cancer Immunotherapy Flt3 Ligand Helps Generate Dendritic Cells for Therapy.
November 30, 1998... Hematopoietic factor Flt3 ligand (Flt3L) combined with other cytokines increases the dendritic cell (DC) population in patients with (pre)neoplastic lesions of the uterine cervix. DC are one of the most efficient antigen presenting cells....

Cancer Immunotherapy IL-15 Activates Tumor-Specific Gamma Delta T Cells.
November 30, 1998... Interleukin (IL)-15 potentiates the in vitro tumor-specific activity and proliferation of peripheral blood gamma delta T cells that have been isolated from glioblastoma cancer patients. Research has shown that gamma delta T cells play a...

Cancer Immunotherapy Intralesional Cytokine Delivery Causes Systemic Toxicity.
November 30, 1998... Intralesional cytokine therapy does not ameliorate systemic toxicity problems for cancer patients. The systemic administration of cytokines as therapy for cancer is complicated by major systemic toxicity. J.A. Davidson and colleagues from...

Cancer Immunotherapy New Melanoma Antigen Discovered.
November 30, 1998... A new shared human melanoma antigen has been identified. R. Lupetti and colleagues from the National Cancer Institute, Italy, reported the identification of a new shared human melanoma antigen that is recognized by a human leukocyte antigen...

Cancer Immunotherapy Synthetic Lipopeptide Induces Tumoricidal Activity.
November 30, 1998... A liposome containing a new synthetic bacterial lipopeptide is a potent activator of macrophage tumoricidal properties. I. Eue and colleagues from the University of Texas MD Anderson Cancer Center studied activation to the tumoricidal state...

Pathogenesis T Cell Understanding Facilitates Immunotherapeutic Strategies.
November 30, 1998... N. Alatrakchi and colleagues from the Institute Gustave Roussy, France, investigated whether T-cell clonal expansion could be found in the blood of 14 untreated patients with B-cell lymphoproliferative disorders ("T Cell Clonal Expansion in...

Conference Coverage (AASLD) Ribavirin/IFN Therapy Twice as Effective as IFN Alone.
November 30, 1998... The largest studies reported to date suggest that combination therapy with ribavirin and interferon is superior to interferon alone for the treatment of chronic hepatitis C virus in both previously treated and untreated patients. The...

HSV Human MAbs For Herpes Therapy and Prevention.
November 30, 1998... A human recombinant monoclonal antibody to herpes simplex virus (HSV) may have therapeutic potential. Alessandro De Logu, The Scripps Research Institute, La Jolla, California, and colleagues reported the characterization of a type-common...

Therapy (TB) Quinolone Fails to Prevent TB Reactivation.
November 30, 1998... A study from Montreal's McGill University found that prolonged ciprofloxacin therapy was not successful in preventing reactivation of tuberculosis. "This case strongly suggests that ciprofloxacin monotherapy lacks prophylactic efficacy,...

Immunology (Malaria)."Transgenic Mice Expressing Human Fetal Globin are Protected From Lethal and Non-Lethal Malaria.".
November 30, 1998... "Transgenic Mice Expressing Human Fetal Globin are Protected From Lethal and Non-Lethal Malaria." H.L. Shear, L. Grinberg, J. Gilman, M.E. Fabry, G. Stamatoyannopoulos, D.D. Goldberg and R.L. Nagel. Montefiore Medical Center and Albert...