Immunotherapy Weekly articles from May 2003

Immunotherapy Weekly archives from May 2003

Roadblocks to tumor vaccines could be overcome with interleukin-2.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Roadblocks to tumor vaccines could be overcome with interleukin-2. "Transforming growth factor-beta (TGF-beta), found at the site of most tumors, has been recognized as one of the mechanisms...

High-speed images show how cells mobilize for immune response.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- New high-speed imaging techniques are allowing scientists to show how a single cell mobilizes its resources to activate its immune response, a new research study shows. Howard R. Petty, PhD,...

Subjects have decreased expression of CD95 on CD4+ T-lymphocytes.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Autism may have an immune dysfunction component, and Fas (CD95) was found to be lower on CD4+ helper T cells and higher as a soluble form in blood. According to recent research published in the...

Pten in B cells controls homeostasis and IgG class switch recombination.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- The tumor suppressor Pten has roles in B cells ranging from B cell development and homeostasis to control of autoantibody production. "Pten is a tumor suppressor gene mutated in human cancers. We...

Interferon-gamma stimulates p11 gene and protein expression in epithelial cells.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Interferon-gamma stimulates p11 gene and protein expression in epithelial cells. "The effect of interferon (IFN)-gamma on p11 expression was studied in two human epithelial cell lines (BEAS-2B and...

Human adherent monocytes/macrophages can now be isolated and cryopreserved.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Human adherent monocytes/macrophages from mononuclear cell apheresis preparations can be isolated and cryopreserved. "There is evidence from animal and human study that suggests clinical use of...

A Na-K-2Cl cotransporter is confirmed in human tracheobronchial smooth muscle.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- A Na-K-2Cl cotransporter is confirmed in trachea and bronchial smooth muscle. According to a study from the United States, "Inhibition of the Na-K-2Cl (NKCC) cotransporter by loop diuretics is...

Activation by CD4-dependent and -independent mechanism is CD154 blockade sensitive.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Activation alloreactive CD8+ T Cells by CD4-dependent and -independent mechanisms is CD154 blockade sensitive. According to recent research published in the Journal of Immunology, "CD154, one of...

Peptone-yeast extract medium preferred in definitive diagnosis of amebiasis.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Peptone-yeast extract medium preferred in definitive diagnosis of amebiasis from Entamoeba histolytica/Entamoeba dispar. "Amebiasis is a common protozoan infection worldwide, causing serious health...

Transgenic mouse model shows glial factor prevents motor neuron loss.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Glial cell line-derived neurotrophic factor protein prevents motor neuron loss of transgenic model mice for amyotrophic lateral sclerosis. "Effects of glial cell line-derived neurotrophic factor...

Immunodominant protein and others identified of B. anthracis exosporium.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Immunodominant protein and others identified of B. anthracis exosporium. According to published research from the United States, "Spores of Bacillus anthracis, the causative agent of anthrax, are...

Correlation between seropositivity, subject age found in children in Mozambique.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Positive correlation between seropositivity for anti-cysticercus antibodies and subject age was found among children living in urban environs of Maputo, Mozambique. "Blood and fecal samples were...

Airozin launched.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Pilot Therapeutics Holdings, Inc., (PLTT), a specialty pharmaceutical company developing and commercializing a portfolio of pharmaceutical and clinically validated over-the-counter (OTC) products,...

Interleukin-13 is a potential target for the treatment of lung disease.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Interleukin-13 is a potential target for the treatment of lung disease. According to a study from the United States, "interleukin (IL)-13 is a key cytokine in asthma pathogenesis. We used...

Treating GERD may reduce need for asthma medications in children.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Children who suffer from both asthma and gastroesophageal reflux disease (GERD) may require fewer asthma medications after receiving anti-GERD treatment, according to a study published in the April...

Human bronchial epithelial cells' nitric oxide induces activator protein-1.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Bronchial epithelial cells' nitric oxide (NO) activates an NO scavenger, activator protein-1 (AP-1). According to published research from Japan, "Exhaled nitric oxide (NO) is increased in...

Vascular tissue fragility occurs in surface areas with thrombolysis.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- The antiplatelet agent trapidil alters the secretion of membrane metalloproteinases and thromobolysis leads to enhanced gelatinolytic activity in human vessels. "Although matrix metalloproteinases...

oxLDL-induced NF-kappaB activation entails ROS generation, proteasome activation.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- oxLDL-induced NF-kappaB activation in atherosclerosis entails ROS generation and proteasome activation, both events being inhibited by HDL. According to recent research from France, "Oxidized...

Human nuclear autoantigen translocates to plasma membrane blebs during apoptosis.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Presumed human nuclear autoantigen translocates to plasma membrane Blebs during apoptosis. "The structure and subcellular localization of a number of molecules change during apoptosis. These...

HLA-B phenotypes B*51 and B*15 have more predictable disease outcome.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Certain HLA-B phenotypes are predictive for different outcomes in Behcet disease. According to recent research from France, "In Moroccan patients, predisposition to Behcet disease is associated with...

Donor T cell-derived TNF is required for graft-versus-host disease.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Donor T cell-derived TNF is required for graft-versus-host disease after bone marrow transplantation. According to published research from the United States, "Previous studies in murine bone marrow...

Activated CD8+ T cells increase clonally in the CNS.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Activated CD8+ T cells are increased in CSF during and after a Borrelia burgdorferi infection of the CNS. "Borrelia burgdorferi may cause an acute infection of the central nervous system (CNS) that...

Potassium channel IK1 and neurotrophin-3 are decreased in the nerves.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Potassium channel IK1 and neurotrophin-3 are decreased in inflamed human bowel nerves and may explain symptoms. According to recent research published in the journal Neuroreport, "Calcium-activated...

Vaccine elicits tumor-specific antibodies in patients with breast cancer.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Researchers have identified tumor-specific antibodies in patients with breast cancer vaccinated with gene-modified allogeneic tumor cells. "Thirty HLA-A2+ women with metastatic breast cancer...

The prodomain of IL-1 alpha interacts with RNA processing elements.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Selective apoptosis of a wide range of tumor cells is obtained with the IL-1alpha precursors' leftover component, the "prodomain"; this component interacts with RNA splicing and processing elements. ...

Hue-Saturation-Intensity (HSI) works better than the gold standard.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Histochemical staining of lung cancer tissue by hue saturation density for levels of proliferating cells with Ki-67 worked better than the gold standard. "We tested a recently developed flexible...

Noncovalent scFv multimers of tumor-targeting humanized antibody constructed.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- According to a study from Australia, "Single-chain variable fragments (scFvs) of anti-Lewis(y) hu3S193 humanized antibody were constructed by joining the V-H and V-L domains with either +2 residues, +1...

Angiogenesis targeting is one way that immunotherapy could fight cancer.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Angiogenesis targeting is one way that immunotherapy could fight cancer. According to a study from Australia, "one of the most controversial issues in immunology for over a century has been whether...

CD4+ cells play critical role in tumor immunity against simian virus 40 antigen.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- CD4+ T lymphocytes played a critical role in antibody production and tumor immunity against simian virus 40 large tumor antigen. According to recent research published in the journal Cancer...

Tumor therapy with epidermal growth factor receptor vaccine investigated.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Immunogene therapy of tumors was investigated with a vaccine based on xenogeneic epidermal growth factor receptor. "The breaking of immune tolerance against self epidermal growth factor receptor...

The terminal complement components are important for immune defense.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- The terminal complement components are important for immune defense against Candida infections. According to a study from Austria, "Candida activates complement via all three pathways leading to...

Defective DNA repair, increased genomic instability is the cause.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Radiosensitive severe combined immunodeficiency results from defective DNA repair and increased genomic instability in artemis-deficient cells. "In developing lymphocytes, the recombination...

Superoxide dismutase is directly implicated in virulence of fungal pathogen.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Superoxide dismutase is directly implicated in virulence of fungal pathogen, C. neoformans var. gattii. According to recent research published in the journal Molecular Microbiology, "The pathogenic...

IL-1 receptor antagonist IL1RN*3 allele predisposes for spontaneous abortion.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Some women with recurrent spontaneous abortions have the IL1RN*3 allele of the IL1 receptor antagonist gene. According to a study from Finland, "Genetic factors may contribute to the development of...

NLS in UL84 protein mediates nuclear import via importin alpha/beta pathway.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Nonconventional nuclear localization signal (NLS) in UL84 protein of human cytomegalovirus mediates nuclear import via importin alpha/beta pathway. "The open reading frame UL84 of human...

Mast cell-derived exosomes induce maturation of dendritic cells.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Mast cell-derived exosomes induced phenotypic and functional maturation of dendritic cells and elicited specific immune responses in vivo. "Mast cells (MCs) are considered major players in...

CD4 T cells crucial as source of CD154 in initiation of type 1 diabetes.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- CD4 T cells are crucial as a functional source of CD154 in the initiation of type 1 diabetes in NOD mice. "Although the critical requirement of CD4 T cells in type 1 (insulin-dependent) diabetes...

Carbohydrates of adult worms characterized by lectin-binding analysis.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Carbohydrates of adult Echinococcus granulosus worms characterized by lectin-binding analysis. According to recent research from Uruguay, "The identification of lectin-binding structures in adult...

Rare case of ADEM developing after allogeneic bone marrow transplantation.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Rare case of acute disseminated encephalomyelitis (ADEM) developed after allogeneic bone marrow transplantation. "Acute disseminated encephalomyelitis (ADEM) is a rare inflammatory demyelinating...

A spectrophotometric assay was developed for prostaglandin E synthase.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- A new spectrophotometric method for detection of the enzyme prostaglandin E synthase is less cumbersome. "The measurement of prostaglandin E synthase (PGES) activity is cumbersome because the...

IL-3 stimulation activates PU.1 transcription factor through p38(MAPK) pathway.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- IL-3 stimulation of mcl-1 gene transcription activates PU.1 transcription factor through p38(MAPK)-dependent pathway. "We have previously demonstrated that the antiapoptotic gene mcl-1 is activated...

Matrix metalloproteinase-12 played an important role in glomerular injury.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Matrix metalloproteinase-12 played an important role in glomerular injury in crescentic glomerulonephritis model. According to a study from Japan, "Rat anti-glomerular basement membrane (GBM)...

Refractory chronic disease is treatable with extracorporeal photochemotherapy.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Photochemotherapy given as treatment for graft-versus-host disease is effective treatment for refractory disease, improving liver enzymes and softening sclerodermatous skin symptoms. ...

HLA-B*5130 is a new allele carrying a rare nucleotide substitution in exon 4.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- A new HLA-B allele with a nucleotide substitution in exon 4 has been termed HLA-B*5130. "We report herein the identification of a new HLA-B*51 allele in a Spanish Caucasoid organ donor. The novel...

Intracellular HSP 70 can be assessed with an immunometric assay.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- A newly developed immunoassay for detection of heat shock protein 70 is comparable to flow cytometry, but lower cost. "Heat shock proteins (Hsp) have been associated to several clinical relevant...

Peptic ulcer disease appears to occur in people with CagA antibodies.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- CagA-specific antibodies are prevalent in peptic ulcer disease, and disease is also independently seen with some specific HLA polymorphisms. According to published research from Germany, "In order...

All glycoprotein B genotypes can be found in all types of infection.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- All four human cytomegalovirus glycoprotein B genotypes can be found in all types of infection. According to a study from Italy, "Human cytomegalovirus (HCMV) strains, obtained from immunocompetent...

Phase II results evaluating Actimmune to be released.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- InterMune, Inc., (ITMN) announced that results of a randomized, double-blind, placebo-controlled phase II clinical trial evaluating Actimmune's (interferon gamma-1b) influence on several underlying...

Tumor-derived suppressor molecules impede host antitumor immune activity.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Tumor-derived suppressor molecules impede host antitumor immune activity. According to recent research published in the journal Experimental Biology and Medicine, "Tumors can evade immune responses...

Regulatory T cells may be subdivided into natural and adaptive types.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Self tolerance and immune response appear to be regulated by T-Reg cells that may be subdivided into natural and adaptive type. "The regulation of immune responses to self-antigens is a complex...

There may be more critical periods of life in psychoneuroimmunology.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- There may be periods of life in which psychological factors play a stronger role in host immunity. According to a study from the United States, "Although it is possible to demonstrate an influence...

Simultaneous intake of 9c,11t and 10t, 12c-CL can change the T cell population.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Simultaneous intake of 9c,11t and 10t, 12c-CL can change the T cell population. "We evaluated the effect of cis-9, trans-11 (9c, 11t) and trans-10, cis-12 (10t, 12c) conjugated linoleic acid (CLA)...

IL-4 impairs anaphylatoxin induced migration of monocytes and dendritic cells.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Human monocytes and dendritic cells will migrate towards mouse peritoneum injected with anaphylatoxins within four hours; and IL-4 will stop that migration. "Anaphylatoxins mobilize leukocytes to...

NO has role in enhancing/propagating inflammatory conditions, immune response.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- NO has role in enhancing and propagating inflammatory conditions and immune response. According to recent research from the United States, "Mitogen-activated protein (AL4P) kinase and nuclear...

Amino acid residues confer temperature sensitivity to influenza virus strains.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Multiple amino acid residues conferred temperature sensitivity to human influenza virus vaccine strains (FluMist) derived from cold-adapted A/Ann Arbor/6/60. "FluMist influenza A vaccine strains...

Virally induced signaling cascades in host cells do not vary; should be targeted.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Host signalling cascades induced by influenza virus may be the best, least variable target for antiviral therapy. According to a study from Germany, "Influenza viruses continue to pose a severe...

Another susceptibility gene was found in the HLA class I region.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Another susceptibility gene was found in the HLA class I region for juvenile idiopathic arthritis. "Juvenile idiopathic arthritis (JIA) is an HLA-associated rheumatic disease with onset in...

Kinetics of GVL and GVH responses were asynchronous.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Kinetics of graft-vs-leukemia (GVL) and graft-vs-host (GVH) responses were asynchronous and could therefore be temporally dissociated by timely ganciclovir (GCV) administration. According to a...

Virus-virus interaction avoids receptor requirement by retroviruses.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Probability of leukemia increases by virus-virus interaction circumvents the virus receptor requirement for infection by pathogenic retroviruses. "During ongoing C-type retrovirus infection, the...

Serum-resistant Borrelia strain evades by expressing CD59-like molecule.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Serum-resistant Borrelia strain evades C-mediated killing by expressing CD59-like complement inhibitory molecule. According to recent research from Italy, "Borrelia burgdorferi the etiological...

Melatonin counteracts PGE2 inhibition of IL-2 production in lymphocytes.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Melatonin acts via its mt1 membrane receptor on human lymphocytes to counteract PGE2's inhibition of IL-2 production. "It is well known that melatonin plays a fundamental role in human...

A cluster of TRIM genes share a conserved coiled coil region.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- TRIM genes within the MHC class I region are related genes with a conserved coiled coil region. According to a study from England, "The major histocompatibility complex (MHC), a region of high gene...

Sensitivity of IL-10, IL-6 signaling define mechanism that contributes potencies.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Different sensitivities of IL-10 and IL-6 signaling toward mechanisms that inhibit the Janus kinase/STAT pathway define an important mechanism that contributes to the different anti-inflammatory...

Infertile men's seminal plasma contains increased IL-6 and lowered IL-10.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Higher proinflammatory IL-6 and lower immunosuppressive IL-10 were found in infertile men's seminal plasma. According to a study from Venezuela, "In vitro studies have reported that seminal plasma...

S100B levels are of value for monitoring patients during chemoimmunotherapy.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- S100B levels are of value for monitoring patients with metastatic malignant melanoma during chemoimmunotherapy. According to a study from The Netherlands, "Serum S100B and lactate dehydrogenase...

Flavonoids may be able to decrease myelin phagocytosis by macrophages.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Flavonoids with specific stereochemistry are able to decrease the amount of demyelination produced by macrophages. According to recent research published in the journal Biochemical Pharmacology,...

Mutations in toll-like receptor 4 are at the same frequency as in normals.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Toll-like receptor 4 polymorphisms that affect degree of inflammation in response to bacterial products are not present in multiple sclerosis (MS) in proportions different from normal. "Multiple...

Residue at position 48 of PhoQ aids switch in kinase- and phosphatase-dominance.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Residue at position 48 of PhoQ aids switch in kinase- and phosphatase-dominance. According to a study from Canada, "The PhoP/PhoQ two-component regulatory system of Salmonella enterica serovar...

Organizing pneumonia was found and treated in a rare pediatric case.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Organizing pneumonia caused by Mycoplasma can occur in children. "We describe a 10 year old boy with organizing pneumonia associated with acute Mycoplasma pneumoniae infection. The diagnosis of...

Human IgG2 can form covalent dimers.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Human IgG2 can form covalent dimers in myeloma cells. According to recent research published in the Journal of Immunology, "Unlike IgA and IgM, IgG has not yet been shown to form covalent polymers....

Impaired PRDI-BF1 transcription repressor identified.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Functionally impaired positive regulatory domain I binding factor 1 (PRDI-BF1) transcription repressor identified in myeloma cell lines. According to published research from the United States, "B...

Activating and inhibitory immune synapses differ in shape and molecules present.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- The activated immune synapse of NK cells has filamentous actin, ezrin, CD45, and CD43, as well as an HLA-C sized synaptic cleft available for binding; while the inhibitory synapse does not. ...

Ubiquitin has several antifungal activities.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Ubiquitin's C terminal fragment has transmembrane antifungal action and inhibits calcineurin, required for fungal growth. According to a study from France, "Secretory granules of chromaffin cells...

Each immunoglobulin-like loop has role in cell-cell adhesion activity.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Each immunoglobulin-like loop has a role in cell-cell adhesion activity. "Nectins are Ca2+-independent immunoglobulin (Ig)-like cell-cell adhesion molecules that form cell-cell junctions,...

Astrocytes perform calcium dependent exocytosis of atrial natriuretic peptide.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Astrocyte release of atrial natriuretic peptide is by calcium dependent exocytosis. According to a study from Slovenia, "Astrocytes are non-neuronal cells in the CNS which, like neurons, are capable...

Microneme protein NcMIC3 vaccine reduces Neospora caninum infection in mice.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Vaccination with recombinant microneme protein NcMIC3 and Ribi adjuvant reduced the incidence of cerebral infection of Neospora caninum-infected mice. According to published research from...

Agonism at MC3-R expressed on peritoneal Mphi leads to inhibition.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Agonism at MC3-R expressed on peritoneal Mphi leads to inhibition of experimental nonimmune peritonitis. According to a study from England, "The issue of which melanocortin receptor (MC-R) is...

G protein-coupled A2a adenosine receptors should be new therapy candidates.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- The natural inflammation control of G protein coupled A2a adenosine receptors should be used to develop anti-inflammatory therapies. "G protein-coupled adenosine receptors are the subject of...

NucliSen Basic Kit NASBA for diagnosis with end-point and real-time detection.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- A NucliSen Basic Kit nucleic acid sequence-based amplification (NASBA) has been developed for diagnosis of parainfluenza virus infection with end-point and real-time detection. According to a study...

Behavioral impairment measures are improved in a new MPTP mouse model.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Behavioral impairment measures are improved in a new 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated-mouse model of parkinsonism. According to recent research published in the Journal...

Neuropeptide Y mRNA expression is differentially upregulated.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Neuropeptide Y mRNA concentration is higher in Parkinson disease patients, and highest in the nucleus accumbens. According to a study from England, "High levels of neuropeptide Y (NPY) are found in...

Efficacy results of DB289 in pneumonia trial released.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Immtech International, Inc., (IMMT) announced the completion of a pilot phase IIa human clinical trial of its oral drug DB289 to treat AIDS patients with Pneumocystis carinii pneumonia (PCP), a form of...

Oral valacyclovir can treat CMV disease following bone marrow transplantation.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Oral valacyclovir is comparable to intravenous ganciclovir for prevention of cytomegalovirus disease after allogeneic bone marrow transplantation. "In this multicenter, randomized study,...

Genotypes are evidence that these cytokines are important in pathogenesis of RPL.
May 7, 2003... 2003 MAY 7 - (NewsRx.com & NewsRx.net) -- Genotypes are evidence that these cytokines are important in pathogenesis of recurrent pregnancy loss (RPL). "Since certain cytokines may play a role in unexplained recurrent pregnancy loss (RPL)...