Immunotherapy Weekly articles from May 1999

Immunotherapy Weekly archives from May 1999

Chimeric Immune Receptors Target Viruses and Cancer.
May 3, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Chimeric immune receptors (CIR) impact T-cell function. CIR encompass tumor- or virus-specific ligands or antibodies fused to the signaling domains of either the T-cell receptor or Fc receptor. T...

IL-2 Dose Intensity May Have Clinical Implications.
May 3, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- A phase II trial of increasing doses of interleukin-2 (IL-2) suggests that this approach may have merit in the treatment of cancer. L. Oleksowicz and colleagues from the Roswell Park Cancer...

Modified Protein Inhibits Murine Mammary Cancer.
May 3, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- A murine model suggests that a modified form of C-reactive protein (CRP) may be a viable anticancer strategy. J.J. Kresl and colleagues from Immtech Int, Inc., Illinois, tested CRP in a murine...

CD9 May Determine Degree of Stem Cell Differentiation.
May 3, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Stromal-cell CD9 may determine the degree of stem cell differentiation, researchers suggest. CD9 belongs to the transmembrane 4 superfamily, and influences cell proliferation, motility, and...

rHuG-CSF Induces PMN Activation.
May 3, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Recombinant human granulocyte colony-stimulating factor induces polymorphonuclear leukocyte activation and may affect some hemostatic variables, researchers report. Granulocyte...

NS5A of HCV Inhibits IFN Activity.
May 3, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- The nonstructural protein 5A of the hepatitis C virus appears to inhibit the antiviral activity of interferon, according to a report from Japan. The non-structural protein 5A (NS5A) of some...

Results of Immunosuppressive Therapy for Transplant Patients Reported.
May 3, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- In an exploratory 12-month study of 55 heart transplant patients, adjunct treatment with the humanized monoclonal antibody Zenapax (daclizumab) reduced the number and severity of early organ...

Company Initiates Phase I Clinical Trial of CpG DNA for Hepatitis B.
May 3, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- CpG ImmunoPharmaceuticals, Wellesley, Massachusetts, and Hilden, Germany, has initiated a Phase I clinical trial of CpG 7909, the company's lead product, for use as a vaccine immune stimulant. ...

Study Shows Probiotic May Boost Immune System.
May 3, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Lactobacillus GG (LGG), a probiotic bacterial strain, may improve the human immune response to vaccines, according to new research presented at the meeting of the Federation of American Societies for...

Bone Marrow With Organ Transplants Reduces Rejection.
May 3, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Organ rejection occurs less often and is less severe in patients who receive infusions of bone marrow from the same donor, researchers from the University of Pittsburgh's Thomas E. Starzl...

Drug Scores Well in Trials.
May 3, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Each year, approximately 28,000 Americans die of pancreatic cancer. Only about 20 percent of cases are detected in time to attempt surgical removal of the tumor, and less than 10 percent of patients...

HLA-A2.1K(b) Transgenic Mice Immunized against G280-9V Anchor Modified Peptide Generate G280 Native Epitope Specific CTL.
May 3, 1999... Cancer Vaccines "HLA-A2.1K(b) Transgenic Mice Immunized against G280-9V Anchor Modified Peptide Generate G280 Native Epitope Specific CTL." G.P. Linette, S. Yang, S. Longerich and F.G. Haluska. Hematology-Oncology Massachusetts General...

Genetic Intervention for Pancreatic and Liver Cancer.
May 3, 1999... Cancer Gene Therapy "Genetic Intervention for Pancreatic and Liver Cancer." Nicholas R. Lernoine. ICRF Molecular Oncology Unit, ICSM at Hammersmith, London, United Kingdom. (CW HENDERSON PUBLISHER www.newsfile.com) -- According to an...

Allogeneic Cellular Immunotherapy by S-59/UVA-Treated Donor Leukocytes in Mice with T Cell Depleted BMT.
May 3, 1999... Cancer Immunotherapy "Allogeneic Cellular Immunotherapy by S-59/UVA-Treated Donor Leukocytes in Mice with T Cell Depleted BMT." R.L. Truitt, B.J. Johnson, S. Tabil and J.E. Hearst. Cancer Center, Medical College of Wisconsin, Milwaukee,...

Comparison of the Humoral and Cellular Immune Response Against MUCII-KLH and GD3-KLH Conjugate Vaccines Mixed with Various Adjuvants.
May 3, 1999... Cancer Vaccines "Comparison of the Humoral and Cellular Immune Response Against MUCII-KLH and GD3-KLH Conjugate Vaccines Mixed with Various Adjuvants." S.K. Kim, G. Ragupathi, C. Musselli and P.O. Livingston. Department of Medicine,...

Interleukin-13 Conjugated Cytotoxin as a Potent Drug for AIDS Kaposi's Sarcoma Xenograft.
May 3, 1999... Drug Development "Interleukin-13 Conjugated Cytotoxin as a Potent Drug for AIDS Kaposi's Sarcoma Xenograft." S.R. Husain and R.K. Puri. Laboratory of Molecular Tumor Biology, Division of Cellular and Gene Therapies, Center for Biologics...

National Guidelines Needed to Manage Rhinitis and Prevent Complications.
May 3, 1999... Allergy Medicine Rachelefsky, G.S. "National Guidelines Needed to Manage Rhinitis and Prevent Complications." Annals of Allergy Asthma & Immunology, March 1999;82(3):296-305. (CW HENDERSON PUBLISHER www.newsfile.com) -- According to...

Appropriate Use of Interferon beta-1a in Multiple Sclerosis.
May 3, 1999... Multiple Sclerosis Jacobs, L.; Brownscheidle, C.M. "Appropriate Use of Interferon beta-1a in Multiple Sclerosis." Biodrugs, March 1999;11(3):155-163. (CW HENDERSON PUBLISHER www.newsfile.com) -- According to the authors' abstract of an...

Improvement in CNS Protective Treatment in Non-High-Risk Childhood Acute Lymphoblastic Leukemia: Report From the Japanese Children's Cancer and Leukemia Study Group.
May 3, 1999... Pediatrics Tsurusawa, M.; Katano, N.; Yamamoto, Y.; Hirota, T.; Koizumi, S.; Watanabe, A.; Takeda, T.; Hatae, Y.; Yatabe, M.; Mimaya, J.; Gushiken, T.; Nishi, K.; Anami, K.; Kikuta, A.; Kanegane, H.; Asami, K.; Nishikawa, K.; Sekine, I.;...

Labeling of Monoclonal Antibodies With Diethylenetriaminepentaacetic Acid-appended Radioiodinated Peptides Containing D-amino Acids.
May 3, 1999... Radioimmunotherapy Govindan, S.V.; Mattes, M.J.; Stein, R.; Mcbride, B.J.; Karacay, H.; Goldenberg, D.M.; Hansen, H.J.; Griffiths, G.L. "Labeling of Monoclonal Antibodies With Diethylenetriaminepentaacetic Acid-appended Radioiodinated...

Hematoporphyrin Derivatives Potentiate the Radiosensitizing Effects of 2-deoxy-D-glucose in Cancer Cells.
May 3, 1999... Radiotherapy Dwarakanath, B.S.; Adhikari, J.S.; Jain, V. "Hematoporphyrin Derivatives Potentiate the Radiosensitizing Effects of 2-deoxy-D-glucose in Cancer Cells." International Journal of Radiation Oncology Biology Physics, March 15,...

Co-Delivery of Cytokines Boosts Immunization Efficacy.
May 10, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Co-delivery of interleukin-12 (IL-12) gives gene gun immunization the boost it needs to induce effective antitumor immunity. DNA-based immunization is a rapidly expanding area of vaccine...

MAGE Genes are Potential Cancer Immunotherapy Targets.
May 10, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Hepatocellular carcinoma tumor-specific immunotherapy may make use of MAGE gene products. Research has demonstrated that the activation of human MAGE genes leads to the expression of a set of...

Monophosphoryl Lipid A Manipulates IFN-gamma Levels.(interferon)
May 10, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- By increasing interferon-gamma (IFN-gamma) levels, monophosphoryl lipid A (MPL) upregulates major histocompatibility complex (MHC) class I expression. C.H. Cho and colleagues from the Inha...

SART-1 Peptide May Join Anticancer Arsenal.
May 10, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- The SART-1 peptide induces tumor-specific cytotoxic T lymphocytes (CTLs). In previous research, M. Kikuchi and colleagues from Kurume University School of Medicine, Japan, described the SART-1...

MAb Facilitates Photodynamic Cancer Therapy.
May 10, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Laboratory coupling merges a photosensitizer to a tumor specific monoclonal antibody (MAb) for targeted photoimmunotherapy. One of the previous limitations of photodynamic therapy has been the...

Heat Shock Protein Plays Role in Modulating Allograft Rejection.
May 10, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Manipulation of a heat shock protein molecule may be useful in changing the course of allograft rejection, findings suggest. Allograft rejection is a process of immune reactivity that is...

Possible Plague Vaccine Antigens ID'd in Mice.(identified)
May 10, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Rodents are blamed for history's devastating plague epidemics, but now they are giving researchers valuable hints for vaccine development. The etiologic agent of pneumonic and bubonic plague,...

PCT Prevents Transfusion-Associated Graft-Versus-Host Disease.
May 10, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Photochemical treatment may offer an alternative to gamma irradiation to prevent transfusion-associated graft-versus-host disease, researchers indicated. Photochemical treatment (PCT) with the...

Transplantation Benefits Substantial Number of AMM Patients.(agnogenic myeloid metaplasia)
May 10, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Allogeneic stem cell transplantation was helpful to certain patients with agnogenic myeloid metaplasia. Patients with agnogenic myeloid metaplasia (AMM), a chronic myeloproliferative disorder,...

Study Finds HIV Likely To Lurk For Years.
May 10, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- HIV can hide in the body for as long as 60 years, even when patients take strong cocktails of drugs, scientists said. Their findings are bad news for those who had hoped the drugs, which can...

Immune Response to Hepatitis B Spares Liver Cells.
May 10, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- A new study suggests that, contrary to current belief, the immune system eliminates most hepatitis B virus (HBV) without resorting to large-scale destruction of infected liver cells. A report of...

Combining, Co-Stimulatory Molecule B7.1-DNA with E7 Peptide Vaccination Enhances the Antigen's Immunological Effect.(Abstract)
May 10, 1999... Cancer Vaccines "Combining, Co-Stimulatory Molecule B7.1-DNA with E7 Peptide Vaccination Enhances the Antigen's Immunological Effect." H. Khong, S. Gur, J. Chun, C.J. Allegra, J.A. Berzofsky and S.N. Khleif. Medicine and Metabolism...

Eradication of Tumors in Mice Transgenic for Carcinoembryonic Antigen (CEA) by Adoptive Immunotherapy.(Abstract)
May 10, 1999... Cancer Vaccines "Eradication of Tumors in Mice Transgenic for Carcinoembryonic Antigen (CEA) by Adoptive Immunotherapy." F.J. Primus, S. Mizobata, K. Tompkins and J.F. Simpson. Wakayama Medical School, Wakayama, Japan; Vanderbilt...

Immune Disregulation in Malaria and Concomitant Measles.
May 10, 1999... Disease Associations "Immune Disregulation in Malaria and Concomitant Measles." Isabella Quakyi. Georgetown University, 37th and 0 Sts NW, Washington, DC 20057. (CW HENDERSON PUBLISHER www.newsfile.com) -- NIH GRANT NUMBER:...

Development of a Leishmania Vaccine Using Interleukin-12 as an Adjuvant.
May 10, 1999... Vaccine Development "Development of a Leishmania Vaccine Using Interleukin-12 as an Adjuvant." R.T. Kenney. Affiliation not available. (CW HENDERSON PUBLISHER www.newsfile.com) -- NIH GRANT NUMBER: 1Z01BI03012-03. PRINCIPLE...

A Newly Identified MAGE-3-derived Epitope Recognized by HLA-A24-Restricted Cytotoxic T Lymphocytes.(Abstract)
May 10, 1999... Cancer Immunotherapy Oiso, M.; Eura, M.; Katsura, F.; Takiguchi, M.; Sobao, Y.; Masuyama, K.; Nakishima, M.; Itoh, K.; Ishikawa, T. "A Newly Identified MAGE-3-derived Epitope Recognized by HLA-A24-Restricted Cytotoxic T Lymphocytes."...

Intratumoral Distribution of Radiolabeled Antibody and Radioimmunotherapy in Experimental Liver Metastases Model of Nude Mouse.(Abstract)
May 10, 1999... Cancer Immunotherapy Sato, N.; Saga, T.; Sakahara, H.; Yao, Z.S.; Nakamoto, Y.; Zhang, M.L.; Kuroki, M.; Matsuoka, Y.; Iida, Y.; Konishi, J. "Intratumoral Distribution of Radiolabeled Antibody and Radioimmunotherapy in Experimental Liver...

Isoniazid Accumulation in Mycobacterium smegmatis Is Modulated by Proton Motive Force-driven and ATP-dependent Extrusion Systems.(Abstract)
May 10, 1999... Drug Resistance Choudhuri, B.S.; Sen, S.; Chakrabarti, P. "Isoniazid Accumulation in Mycobacterium smegmatis Is Modulated by Proton Motive Force-driven and ATP-dependent Extrusion Systems." Biochemical and Biophysical Research...

Electrocardiographic Changes During Low-dose, Short-term Therapy of Cutaneous Leishmaniasis With the Pentavalent Antimonial Meglumine.(Abstract)
May 10, 1999... Leishmaniasis (Therapy) Ribeiro, A.L.P.; Drummond, J.B.; Volpini, A.C.; Andrade, A.C.; Passos, V.M.A. "Electrocardiographic Changes During Low-dose, Short-term Therapy of Cutaneous Leishmaniasis With the Pentavalent Antimonial Meglumine."...

Antimalarial Prophylaxis - Use and Adverse Events in Visitors to the Kruger National Park.(Abstract)
May 10, 1999... Malaria (Prophylaxis) Durrheim, D.N.; Gammon, S.; Waner, S.; Braack, L.E.O. "Antimalarial Prophylaxis - Use and Adverse Events in Visitors to the Kruger National Park." South African Medical Journal, February 1999;89(2):170-175. (CW...

Bisquinoline Antimalarials: Their Role in Malaria Chemotherapy.(Abstract)
May 10, 1999... Malaria (Therapy) Raynes, K. "Bisquinoline Antimalarials: Their Role in Malaria Chemotherapy." International Journal for Parasitology, March 1999;29(3):367-379. (CW HENDERSON PUBLISHER www.newsfile.com) -- According to the author's...

Predictors for Multidrug-resistant Tuberculosis Among HIV Infected Patients and Response to Specific Drug Regimens.(Abstract)
May 10, 1999... TB (Drug Resistance) Telzak, E.E.; Chirgwin, K.D.; Nelson, E.T.; Matts, J.P.; Sepkowitz, K.A.; Benson, C.A.; Perlman, D.C.; Elsadr, W.M. "Predictors for Multidrug-resistant Tuberculosis Among HIV Infected Patients and Response to Specific...

HIV Inhibited by Anti-Integrase SFv Delivered by SV40 Vector.
May 17, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- An SV40 vector delivering an anti-integrase (IN) single-chain variable fragment (SFv) inhibited HIV-1 replication in infected cells. M. BouHamden and colleagues from the Thomas Jefferson...

Bee Venom Immunotherapy Still Needs Intensive Scrutiny.
May 17, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Patient individuality needs to be incorporated into bee venom immunotherapy research. A. Kettner and colleagues from CHU Vaudois, Switzerland, studied bee venom allergens in various patients...

High-Risk Subjects May Have Delayed Reaction To Therapy.
May 17, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- High-risk patients receiving immunotherapy for allergies may need to hang out for evaluation a little longer than the norm. M. Karaayvaz and colleagues from the Gulhane Military Medical Academy,...

RCC Brain Metastases Succumb to IFN-(alpha) Therapy.
May 17, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- A case report demonstrates the successful use of interferon-alpha (IFN-(alpha)) for brain metastases of renal cell carcinoma. J. Murata and colleagues from the Hokkaido University School of...

Triple Therapy Successful for Some Metastatic RCC.
May 17, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Triple combination therapy works in approximately 20 percent of metastatic renal cell carcinoma (RCC) patients. D. Samland and colleagues from the University Magdeburg, Germany, evaluated the...

Liposomes Can Act as Antigen-Presenting Vesicles.
May 17, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Liposomes may serve as artificial antigen presenting cells. A.J.M.L. Vanrensen and colleagues from the Utrecht Institute of Pharmaceutical Sciences, The Netherlands, designed a well-characterized...

Vaccine Strategy Promises HIV Containment.
May 17, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Elegant primate experiments point the way to a vaccine that can contain, but not prevent, HIV infection. Monkeys primed with intradermal HIV DNA and boosted with recombinant fowlpox virus...

H37Rv Antibodies in CSF Don't Identify TB Meningitis.
May 17, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- The detection of antibodies against H37Rv in cerebrospinal fluid serum does not aid in the diagnosis of tuberculosis meningitis, according to a report from India. K.L. Srivastava and colleagues...

Mechanism of flt3 Ligand Expression in Bone Marrow Failure.
May 17, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Increased levels of flt3 ligand in bone marrow failure are due to the mobilization of preformed flt3 ligand from intracellular stores, study findings indicate. The flt3 ligand (FL) is a growth...

Stem Cell Factor or Increased Receptor Expression Is Needed.
May 17, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Interleukin-5 required the costimulation of stem cell factor for optimal hematopoietic progenitor cell line proliferation. The proliferation of hematopoietic stem cells in vitro requires...

Immunomodulator Effects of Allogeneic Blood Transfusions.
May 17, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Potential immunomodulatory effects of allogeneic blood transfusions should be considered in clinical practice, researchers indicated. Although the immunomodulatory effect of allogeneic blood...

IL-12 Shows Little Activity in Phase I/II Studies.
May 17, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Recombinant human interleukin-12 does not appear to be as active as existing therapies in the treatment of chronic hepatitis C, according to a phase I/II study from Germany. Recombinant human...

Study is First to Find that IFN Worsens Asthma.
May 17, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Interferon-alpha appears to dramatically exacerbate existing asthma in patients receiving treatment for chronic hepatitis C virus. Interferon-alpha is used by physicians to treat numerous common...

Impact of IFNs on Testis Examined.
May 17, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- A report from France explores the impact of interferons and interferon-induced antiviral proteins in the testis. Interferons (IFNs) are proteins playing a key role in the antiviral defense...

Form of Chinese Herb Found To Temper Immune System and Kill Cancer Cells.
May 17, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Researchers at the Stanford University School of Medicine, Stanford, California, have discovered that a perennial herb used by the Chinese for hundreds of years to relieve rheumatoid arthritis...

Company Aims To Clone Human Tissue for Transplants.
May 17, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- By acquiring a research company formed by the Scottish institute famous for cloning Dolly the sheep, California biotechnology firm Geron Corp., Silicon Valley, California, hopes one day to clone...

Leukine Drug Extends HIV Therapy.
May 17, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Immunex Corp., Los Angeles, California, said its cancer drug Leukine helps AIDS patients stay on their drug cocktails longer without developing resistance to the drugs - so long as they were started...

Key Peptides Found that Stop - Even Reverse - Kidney Disease in Lupus Patients.
May 17, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Northwestern University Medical School (Chicago, Illinois) researchers have identified key peptides - small bits of proteins - that halt kidney disease in lupus, an autoimmune disease that attacks...

Gene-Based Therapy Promising in Cancer Trials.
May 17, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Results from a Phase I/II trial indicate that the gene-based prostate cancer therapy Leuvectin may complement conventional surgical and radiotherapy treatments in controlling progress of the disease....

Therapy Shows Promise in Preventing Rejection of Transplanted Organs.
May 17, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- A therapeutic approach that appears to significantly reduce the rejection risk of transplanted organs is currently being studied in multi-center clinical trials but already has been adopted as an...

Shifting Towards Better Immunotherapy Rather Than More Intensive Chemoradiotherapy Using a Nonmyeloablative Approach in Patients with Leukemia.
May 17, 1999... Cancer Immunotherapy "Shifting Towards Better Immunotherapy Rather Than More Intensive Chemoradiotherapy Using a Nonmyeloablative Approach in Patients with Leukemia." S. Slavin, A. Nagler, E. Naparstek, M. Aker, G. Varati, R. Ben-Yosef, G....

Immunotoxin Therapy of Solid Tumors - Preclinical Studies.
May 17, 1999... Cancer Immunotherapy "Immunotoxin Therapy of Solid Tumors - Preclinical Studies." I. Pastan. Current affiliation unavailable. (CW HENDERSON PUBLISHER www.newsfile.com) -- NIH GRANT NUMBER: 1Z01BC08753-16. PRINCIPLE INVESTIGATOR: I....

Antibody Response to Neuraminidase of the Influenza Virus in Children with Acute Lymphoblastic Leukemia Vaccinated Against Influenza After Chemotherapy.
May 17, 1999... Prophylaxis (Flu) "Antibody Response to Neuraminidase of the Influenza Virus in Children with Acute Lymphoblastic Leukemia Vaccinated Against Influenza After Chemotherapy." R. Rokicka-Milewskal, L.B. Brydak, M. Machala and T. Jackowska....

Immunotherapy of Alzheimer's Disease.
May 17, 1999... Therapy (Alzheimer's) "Immunotherapy of Alzheimer's Disease." Victor A. Raso. Boston Biotechnology Corporation, 20 Staniford Street, Boston, Massachusetts 02114. (CW HENDERSON PUBLISHER www.newsfile.com) -- NIH GRANT NUMBER:...

Immune Parameters Accompanying Long-Term Graft Success.
May 17, 1999... Transplant Immunology "Immune Parameters Accompanying Long-Term Graft Success." Nancy L. Reinsmoen. Duke University, Durham, North Carolina 27706. (CW HENDERSON PUBLISHER www.newsfile.com) -- NIH GRANT NUMBER: 1R21AI43286-01. GRANT...

Transplant Immunology of IL2 IFN Gamma Double Knockout Mice.
May 17, 1999... Transplant Immunology "Transplant Immunology of IL2 IFN Gamma Double Knockout Mice." Martin Zand. University of Rochester, River Campus Station, Rochester, New York 14627. (CW HENDERSON PUBLISHER www.newsfile.com) -- NIH GRANT NUMBER:...

Somatostatin Receptor Subtype Expression in Cells of the Rat Immune System During Adjuvant Arthritis.
May 17, 1999... Arthritis (Animal Models) Tenbokum, A.M.C.; Lichtenauerkaligis, E.G.R.; Melief, M.J.; Vankoetsveld, P.M.; Bruns, C.; Vanhagen, P.M.; Hofland, L.J.; Lamberts, S.W.J.; Hazenberg, M.P. "Somatostatin Receptor Subtype Expression in Cells of the...

Elevated Circulating Levels of Soluble Interleukin-1 Receptor Type II During Interleukin-2 Immunotherapy.
May 17, 1999... Interleukins Vannier, E.; Kaser, A.; Atkins, M.B.; Fantuzzi, G.; Dinarello, C.A.; Mier, J.W.; Tilg, H. "Elevated Circulating Levels of Soluble Interleukin-1 Receptor Type II During Interleukin-2 Immunotherapy." European Cytokine Network,...

Acute Isoniazid Exposures and Antidote Availability.
May 17, 1999... Isoniazid-Related Poisonings Santucci, K.A.; Shah, B.R.; Linakis, J.G. "Acute Isoniazid Exposures and Antidote Availability." Pediatric Emergency Care, April 1999;15(2):99-101. (CW HENDERSON PUBLISHER www.newsfile.com) -- According to...

Phase I/II Trial of I-131-MN-14 F(Ab)(2) Anti-carcinoembryonic Antigen Monoclonal Antibody in the Treatment of Patients With Metastatic Medullary Thyroid Carcinoma.
May 17, 1999... Monoclonal Antibodies Juweid, M.E.; Hajjar, G.; Swayne, L.C.; Sharkey, R.M.; Suleiman, S.; Herskovic, T.; Pereira, M.; Rubin, A.D.; Goldenberg, D.M. "Phase I/II Trial of I-131-MN-14 F(Ab)(2) Anti-carcinoembryonic Antigen Monoclonal...

Pharmacodynamics of Vancomycin for the Treatment of Experimental Penicillin- and Cephalosporin-resistant Pneumococcal Meningitis.
May 17, 1999... Pneumococcal Meningitis Ahmed, A.; Jafri, H.; Lutsar, I.; Mccoig, C.C.; Trujillo, M.; Wubbel, L.; Shelton, S.; Mccracken, G.H. "Pharmacodynamics of Vancomycin for the Treatment of Experimental Penicillin- and Cephalosporin-resistant...

CTLA4Ig In Dendritic Cells Promotes Allograft Survival.
May 24, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Genetically-modified dendritic cells (DC) can promote their own tolerance and thus enhance their survival in allogeneic recipients. DC are highly specialized antigen-presenting cells (APC). They...

Clinical Trial Compares Loratadine and Cetirizine.
May 24, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- A study suggests that the effect of H1-blockers differs depending on the target organ. L. Persi and colleagues from the Hopital Arnaud de Villeneuve, France, conducted a double-blind,...

Immunotherapy Reduces Asthma-Related Complications.
May 24, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Allergen immunotherapy combined with inhaled corticosteroids helps reduce asthma-related complications in allergic children. Immunotherapy has been shown to reduce sensitivity to allergens such...

Combination Therapy Inhibits Breast Cancer Cell Growth.
May 24, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Combination therapy provides the basis for a novel strategy against breast cancer. Taking advantage of the fact that type I protein kinase A (PKAI) is overexpressed in the majority of human...

Different IgG Subclasses Have Different Inhibitory Activities.
May 24, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- The inhibitory effect of IgG depends on the different subclasses. The degranulation of mast cells in an allergic response is initiated by the aggregation of high-affinity IgE receptors (Fc...

Monitoring of Antitumor Immune Responses Necessary.
May 24, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Monitoring antitumor immune responses during immunotherapy for cancer will provide insights for further improvement. Cancer remains one of the most important public health concerns, noted...

Distribution of Latent Viral Genomes in Cell Populations.
May 24, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- The cytomegalovirus genome can be detected and quantitated directly in naturally infected populations, researchers report. Human cytomegalovirus (CMV) is a medically important betaherpesvirus...

Lymphocyte Gene Therapy in Trial for MPS II.
May 24, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- A procedure to expand and transduce cryopreserved autologous peripheral blood lymphocytes may be effective in gene therapy for mucopolysaccharidosis. Mucopolysaccharidosis type II (MPS II), or...

Anti-HCV Core IgM Predict Long-Term IFN Response.
May 24, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Hepatitis C virus antibody core immunoglobulin M levels may be sensitive predictors of long-term interferon response in patients with chronic hepatitis C infection. In this study, C. Vandelli...

Long-Term Microchimerism Seen in Trauma Patients.
May 24, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Long-term multilineage chimerism in severe trauma patients who received transfusion may be caused by the engraftment of donor stem cells. "Establishment of long-term multilineage chimerism in...