Immunotherapy Weekly articles from March 2003

Immunotherapy Weekly archives from March 2003

Monoclonal antibody may control disease in children.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- Crohn disease, a painful inflammation of the gastrointestinal tract, affects more than 100,000 children in the U.S., causing emotional and social difficulties in addition to its physical symptoms. A...

Tolerance to bacterial lipoprotein enhances survival to many challenges.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- According to a study from Ireland, "Tolerance to bacterial cell wall components is an adaptive host response. Endotoxin/LPS tolerance is characterized by a survival advantage against subsequent lethal...

IL-28, IL-29 are induced by virus and act through an IL-10 receptor.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- "Cytokines play a critical role in modulating the innate and adaptive immune systems. Here, we have identified from the human genomic sequence a family of three cytokines, designated interleukin 28A...

Family history has limited predictive value for risk.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- Although a family history of asthma is associated with increased risk of asthma in children, family history does not successfully predict enough cases of childhood asthma to be a useful tool in guiding...

Cyclosporine testing reveals a marked post-transplant decrease in clearance.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- "Cyclosporine (CyA) is an immunosuppressant metabolized primarily by the liver and small intestine. The pharmacokinetics of CyA was studied in 6 patients prior to and 1-3 months after liver...

Novel role for immunosuppressive galectin-1 in reproductive biology.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- "Galectin-1, a highly conserved beta-galactoside-binding protein, induces apoptosis of activated T cells and suppresses the development of autoimmunity and chronic inflammation. To gain insight...

The TNF beta gene polymorphism B2B2 is associated with sepsis.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- "In injured patients, it has been shown that a polymorphism of the tumor necrosis factor-beta (TNFbeta) gene is related to the development of sepsis. We investigated the relation of TNFbeta gene...

Polyps linked with colorectal carcinoma via microsatellite instability pathway.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- "The ''hyperplastic polyp'' is considered a benign lesion with no malignant potential, whereas ''serrated adenoma'' is a precursor of adenocarcinoma. The morphologic complexity of the serrated adenoma...

Spectrum broadens as cases reveal previously undescribed mucinous subtype.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- A study from Peoples Republic of China reports "2 cases of primary thymic adenocarcinoma, a very uncommon neoplasm with limited information in the literature. Both patients were men; aged 15 and 39...

E3 promoter responds to activation signals in human T cells.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- According to a study in the United States, "The group C adenoviruses typically cause acute respiratory disease in young children. In addition, a persistent phase of infection has been observed in which...

Apoptotic sensitivity largely confined to cells recently entering the cell cycle.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- "Depending on timing and dose, exogenous glucocorticoids induce a wave of apoptosis in the adult rat anterior pituitary, a response that is enhanced by adrenalectomy. In this study, we show that the...

Only low level LPS inhalation induces a TLR4 dependent Th2 response.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- According to a study from the United States, "Allergic asthma is an inflammatory lung disease initiated and directed by T helper cells type 2 (Th2). The mechanism involved in generation of Th2 responses...

Educational information and coupons about new OTC drug provided.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- Aetna (NYSE:AET) announced a program to provide approximately 475,000 commercial members with information about over-the-counter (OTC) non-sedating antihistamines (NSA) and coupons to purchase Alavert,...

Private label gains marketing rights to loratadine 10 mg tablet equivalent.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- Leiner Health Products has secured the marketing rights to the antihistamine loratadine immediate release 10 milligram tablets (Claritin 10 milligram tablets). Through an exclusive licensing...

A single promoter variant in the TNFRSF6 gene appears to be associated.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- "The tumor necrosis factor receptor superfamily, member 6 gene (TNFRSF6) is situated on chromosome 10q, near the region indicated in several AD linkage studies. In a previous study a significant...

CAP37, a monocyte recruiter, may also serve as a neuroinflammatory protein.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- According to a study from the United States, "Recent evidence suggests that inflammation and immune function in the central, nervous system (CNS) may play a considerable role in the progression of many...

Nectin-1 alpha has role in PS/gamma-secretase-like proteolytic activity.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- "Nectin-1 is a member of the immunoglobulin superfamily and a Ca2+-independent adherens junction protein involved in synapse formation. Here we show that nectin-la undergoes intramembrane proteolytic...

NPY-like immunoreactive system in brain, olfactory organ, retina in ontogeny.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- According to recent research in Italy, "The anatomical distribution of neuropeptide tyrosine (NPY)-like immunoreactivity was investigated in the brain, olfactory organ and retina of the zebrafish, Danio...

Failure to sequester autoreactive B cells adds to breakdown of tolerance.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- According to recent research in the United States, "We have studied the regulation of anti-DNA B cells in transgenic mice with a heavy chain transgene (3H9H/56R). This transgene codes for a heavy chain...

CD1-mediated gamma/delta T cells, TNF alpha can induce dendritic cell maturation.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- "Immature myeloid dendritic cells (DCs) express only low levels of MHC class II but express high levels of CD1 a, b, and c antigen-presenting molecules at the cell surface. As Vdelta1(+) gamma/delta T...

New pool of B lymphocytes have large amount of kappa double-productive B cells.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- According to a study from Israel, "The extent of allelic exclusion in Ig genes is very high, although not absolute. Thus far, it has not been clearly established whether rapid selection of the...

Natural killer cells with IL-18 receptors respond effectively to IL-18.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- According to recent research from Japan, "IL-18 administration promotes innate immunity resulting in significant antitumor effects in multiple murine tumor models. Here, we examined the effector...

Three IFN-lambdas act through a distinct class II cytokine receptor complex.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- Recent research from the United States reports "the identification of a ligand-receptor system that, upon engagement, leads to the establishment of an antiviral state. Three closely positioned genes on...

Protection of follicular and MZ B cells requires CD19-dependent survival signals.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- According to recent research in the United States, "Loss of membrane-bound Ig results in the rapid onset of apoptosis in recirculating B cells. This observation implies that a competent B cell receptor...

Mitochondrial injury key in eosinophil apoptosis, enhanced by GCs.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- According to a study in the United States, "The mainstay of asthma therapy, glucocorticosteroids (GCs) have among their therapeutic effects the inhibition of inflammatory cytokine production and...

Ku86 is degraded to variant Ku86 by an inducible serine protease.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- According to a study from Sweden, "The Ku autoantigen has been implicated in a number of cellular functions including growth control, immunoglobulin gene rearrangement, and DNA repair. A variant...

Wrong protein implicated in autoimmunity.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- The evidence seemed convincing that a protein called interleukin-12 is a major contributor to autoimmune disorders. But a new report argues that interleukin-12 has been wrongly accused, at least in the...

Intravenous gammaglobulin (IVIg) treatment does involve many risks.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- According to recent research from the United States, "Intravenous immune globulin (IVIg) is considered an effective and safe treatment for autoimmune neuropathies, especially in comparison to the...

DAT optimizes dopaminergic transmission in synaptic cleft during degeneration.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- "We have evaluated the ability of the injured nigrostriatal dopaminergic system to produce highly reactive hydroxyl radicals ((OH)-O-.) by the electrochemical detection of salicylate hydroxylation. ...

Expression patterns of CD14 and CD16 generate PMN phenotype for severe infection.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- "In polymorphonuclear neutrophils (PMN) CD14, one of the receptors for lipopolysaccharides (LPS) is stored intracellularly as a preformed protein, with only few receptors expressed on the surface. We...

Pathogenic E. coli O78 strain adheres to surfaces of intestinal tract.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- "The role of fimbria in adherence of an avian pathogenic Escherichia coli (APEC) 078 strain 789 to chicken intestine was studied. Bacterial adhesion to tissue sections representing the regions within...

Extremely low frequency magnetic fields do not affect immune activity.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- According to a study from Japan, "Several epidemiologic studies have suggested an association between exposure to extremely low frequency (ELF) magnetic fields (MFs) and cancer in adults and children. A...

Expression of ECM components in a highly infiltrative in vivo glioma model.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- "This work demonstrates the expression of extracellular matrix (ECM) components in a highly infiltrative brain tumor model developed by simple inoculation of spheroids from five human glioma biopsy...

Immunohistochemical distinction of invasive from noninvasive breast lesions.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- According to recent research in the United States, "Identification of myoepithelial cells using antibodies to cytoskeletal proteins, such as smooth muscle myosin heavy chain (SMM-HC) and calponin, can...

Rheumatic syndromes are associated with malignancy.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- "The relation between rheumatic syndromes and an underlying malignancy is a complex one. As a result of autoimmunity, an aberrant immune response, or the use of immunomodulatory drugs, many of the...

G protein-RACK1 forms signaling scaffold important for intracellular responses.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- According to a study in the United States, "A yeast two-hybrid approach was used to discern possible new effectors for the betagamma subunit of heterotrimeric G proteins. Three of the clones isolated...

SHP-1 acts to negatively regulate IL-3-driven survival and proliferation.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- "The tyrosine phosphatase SHP-1 (Src homology phosphatase-1) has been widely implicated as a negative regulator of signaling in immune cells. We have investigated in detail the role of SHP-1 in...

Report of signal cascade controlled by IL-2 that mediates NK cell survival.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- "Interleukin-2 (IL-2) prevents cell apoptosis and promotes survival, but the involved mechanisms have not been completely defined. Although phosphatidylinositide 3-kinase (PI 3-kinase) has been...

Growth arrest of HPV-positive cells is independent of E6/E7 oncogene expression.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- "Inhibitors of histone deacetylase (HDAC) are capable of arresting growth in cervical carcinoma cells in the G1 phase of the cell cycle. Although HPV E6/E7 mRNA steady-state levels appeared to be...

Testicular germ-cell apoptosis after combined exposure to test compounds.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- According to recent research in the United States, "This study reports and characterizes the testicular apoptosis following daily exposure of male Sprague-Dawley rats to subchronic combined doses of...

Adrenal hormone and cortisol stress reactions were lowered by some GI drugs.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- According to recent research from Japan, "Rikkunshi-to, a gastrointestinal function regulatory traditional Chinese herbal (Kampo) medicine, has recently been evaluated for its clinical usefulness in...

Antiinflammatory therapy effects additive, alter decline of pulmonary function.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- According to a study in the United States, "Some of the most important pathobiology in cystic fibrosis occurs not as a direct result of impaired chloride transport, but the downstream consequences of...

IRF-4 plays role in control of T lymphocyte ability to produce cytokines.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- "Production of cytokines is one of the major mechanisms employed by CD4[superscript]+ T cells to coordinate immune responses. Although the molecular mechanisms controlling T cell cytokine production...

IE1 binds to HDAC-2 to undo suppression of viral transcription and replication.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- According to a study from the United States, "Herpesviruses start their transcriptional cascade at nuclear domain 10 (ND10). The deposition of virus genomes at these nuclear sites occurs due to the...

Granzyme B-serglycin complex comes in two packaging sizes for exocytosis.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- "We have recently shown that the physiological mediator of granule-mediated apoptosis is a macromolecular complex of granzymes and perforin complexed with the chondroitin-sulfate proteoglycan,...

AN/BN patients have autoantibodies that bind to alpha-MSH, ACTH, and LHRH.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- "The hypothalamic arcuate nucleus is involved in the control of energy intake and expenditure and may participate in the pathogenesis of eating disorders such as anorexia nervosa (AN) and bulimia...

NOSTRIN modulates NO release and subcellular distribution of eNOS.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- According to recent research in Germany, "Activity and localization of endothelial nitric oxide synthase (eNOS) is regulated in a remarkably complex fashion, yet the complex molecular machinery...

Monocyte-derived cells enhance antimicrobial response to lipopolysaccharide.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- According to recent research from the United States, "Epithelia react to microbial pathogens by mounting a defensive response that includes the production of antimicrobial peptides. "In this study,...

EBI3 plays role in Th2-type immune responses induction, inflammation development.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- According to a study from the United States, "Epstein-Barr virus-induced gene 3 (EBI3) is a widely expressed IL-12p40-related protein that associates as a heterodimer with either IL-12p35 or an IL-12p35...

vIL-10 inhibition of antigen-presenting function may help in EBV immune evasion.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- According to recent research in the United States, "Monocytes and macrophages play a central role in viral infections, as a target for viruses and in activation of both innate and adaptive immune...

The shrimp allergen, Pen m 2, has homology to arginine kinase in all crustaceans.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- According to a study from Taiwan, "Shellfish are a common cause of adverse food reactions in hypersensitive individuals, and shrimp is one of the most frequently reported causes of allergic reactions. A...

Agonist ligand ability to maintain ternary complex results in increased agonist potency.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- According to recent research in the United States, "Responses to partial agonist TCR signals include positive selection of thymocytes, survival of naive T cells, and homeostatic proliferation. As part...

BF cholinergic neuron lesions lead to increase in susceptibility.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- According to recent research from the United States, "The cholinergic system modulates cerebral excitability. We recently reported that immunolesions of the basal forebrain (BF) cholinergic neurons in...

LF 15-0195 enhances AICD by facilitating caspase-8 and caspase-10 activation.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- According to recent research from France, "The deoxyspergualin derivative LF 150195 has demonstrated some efficacy in animal models of autoimmune and graft-versus-host diseases and is currently tested...

Reduction in activated B cells can be achieved by SLC/CCR ligand 21 therapy.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- "The use of receptor antagonists for chemokines is an alternative approach to blocking chemokine actions and has the potential to provide novel therapeutics. We determined the receptor antagonist...

Role of the mitogen-activated protein kinase cascade in regulating apoptosis.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- "Progesterone (P4) inhibits both granulosa cells and spontaneously immortalized granulosa cells (SIGCs) from undergoing apoptosis. P4 does so through a plasma membrane-initiated event. It appears that...

Interleukin-15 overexpression prevents murine AIDS.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- Interleukin (IL)-15 may slow or prevent AIDS progression, researchers in Japan say. "LP-BM5 murine leukemia virus (MuLV) infection causes murine acquired immunodeficiency syndrome (MAIDS), a disease...

Apoptotic, infected cells effective in animals.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Researchers in Sweden have identified a novel and effective method for inducing HIV-specific immune activity. Antigen (Ag)-presenting dendritic cells...

Researchers design CD4 mimic that inhibits HIV-1 entry.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- "The conserved surfaces of the human immunodeficiency virus (HIV)-1 envelope involved in receptor binding represent potential targets for the development of entry inhibitors and neutralizing antibodies....

Therapeutic dendritic-cell vaccine effective against simian AIDS.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- "An effective immune response against human immunodeficiency virus or simian immunodeficiency virus (SIV) is critical in achieving control of viral replication. Here, we show in SIV-infected rhesus...

Resistance to syncytia is due to viral protein's truncation.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- "Human T-cell leukemia virus (HTLV) envelope (Env) glycoproteins induce fusion, leading to rampant syncytium formation in a broad range of cell lines. Here, we identified murine, hamster, canine, and...

CXCR2 homologue enhances reactivation from latency.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- "The open reading frame (ORF) 74 of gamma-2-herpesviruses encodes a G protein-coupled receptor which is highly conserved in members of this subfamily and is homologous to the CXCR2 chemokine receptor....

Mapping of lymphoma-related features onto phylogenetic tree is new research tool.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- "In order to integrate evolutionary concepts into lymphoma research we mapped features of classic Hodgkin lymphoma (a disease which has been recently described to be derived from germinal center...

Human CMV UL97, an antiviral drug target, is required at nuclear egress.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- According to recent research from the United States, "Human cytomegalovirus encodes an unusual protein kinase, UL97, that activates the established antiviral drug ganciclovir and is specifically...

Many transcriptional activators participate in HTLV-I transcription regulation.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- According to a study in the United States, "The human T-cell leukemia virus (HTLV-I)-encoded Tax protein is a potent transcriptional activator that stimulates expression of the integrated provirus. ...

Different IVIg preparations can affect tolerability and efficacy variably.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- "The use of intravenous immune globulin (IVIg) has increased significantly in the past decade, benefiting a wide variety of immune diseases. Seven different formulations of IVIg are now licensed in the...

PHD domain, a zinc finger, is linked to E3 ubiquitin ligase activity.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- According to a study from the United States, "PHD domains constitute a widely distributed subfamily of zinc fingers whose biochemical functions have been unclear until now. Recently, several PHD...

L-selectin (CD62L) is particular to a set of resting memory CD4(+) T cells.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- According to recent research from the United States, "Naive CD4(+) T cells use L-selectin (CD62L) expression to facilitate immune surveillance. However, the reasons for its expression on a subset of...

Toll-like receptors act as sensors in immune surveillance.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- According to a study from Japan, "Natural IFN-alpha/beta producing cells (IPCs) play a central role in innate immunity against microbial infections. In primary immune responses, toll-like receptors...

New insight into differences between circulating gammadelta T cell subsets.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- According to recent research in the United States, "Gene expression profiles were compared in circulating bovine GD3.5[superscript]+ (CD8[superscript]-) and GD3.5[superscript]- (predominantly...

Effects of cis-nonachlor, trans-nonachlor, and chlordane on the immune system.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- According to a study in Canada, "The immunotoxicity of cis- and trans-nonachlor and chlordane were investigated in adult male and female Sprague-Dawley rats following a 28-day oral (gavage) treatment....

MIF may have role in both homeostatic, physiological action of glucocorticoids.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- "Glucocorticoid hormones are important antiinflammatory agents because of their antiinflammatory and proapoptotic action within the immune system. Their clinical usefulness remains limited however by...

Calpain may be a novel therapeutic target for regulation of mast cell activity.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- According to recent research in Canada, "Nitric oxide is an important messenger that regulates mast cell activity by modifications to gene expression and intracellular pathways associated with...

Mature T lymphocytes, bronchial and salivary cells produce limitin glycoprotein.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- According to recent research from Japan, "Several reports have described multifunctional eukaryotic mRNAs producing more than one protein through alternative translational initiation at multiple AUG...

TNF-alpha is potential target for treatment intervention.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- According to recent research from New Zealand, "Increased production of PGs by gestational membranes is believed to be a principal initiator of term and preterm labor. Intrauterine infection is...

PAF may impinge on regulation of immune response by regulating activity of MDDC.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- "Although macrophages (Mphi) and monocyte-derived dendritic cells (MDDC) come from a common precursor, they are distinct cell types. This report compares the two cell types with respect to the...

Elongation factor-1 alpha activates SHP-1 leading to macrophage deactivation.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- According to a study from Canada, "The human leishmaniasis are persistent infections of macrophages caused by protozoa of the genus Leishmania. The chronic nature of these infections is in part related...

New HuMax-CD20 and HuMax-EGFr preclinical data presented.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- Genmab A/S announced that its HuMax-CD20 human antibody appears to kill tumor cells that are resistant to rituximab, a marketed antibody directed to the same disease target. In preclinical testing,...

Targeted immunotherapy eradicates cancer in mice.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- Researchers have developed a novel approach to genetically instruct human immune cells to recognize and kill cancer cells in a mouse model. The investigators plan to ultimately apply this strategy in a...

Green tea antioxidant lowers activated stellate cells, gene products.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- According to recent research from the United States, "Activated hepatic stellate cells (HSC) are the primary source of excessive production of extracellular matrix during liver fibrogenesis. Although...

Potential role of apoptotic macrophages in pulmonary inflammation and fibrosis.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- According to recent research from the United States, "Induction of apoptosis has been associated with a variety of exposures which result in inflammatory and fibrotic lung disorders. Macrophages are key...

Genetic 'signature' linked to severe symptoms.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- A team of scientists supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), and other parts of the U.S. National Institutes of Health (NIH) and the private...

vSAg29 expression impacts development of germinal center-derived B cell disease.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- "Mammary tumor virus (Mtv29)-encoded superantigen expressed by SJL/J mouse B cell lymphomas stimulates CD4(+)Vbeta16(+) T cells and thereby acquires T cell help necessary for lymphoma growth. Mtv29...

Astrocytes and Muller cells express multiple connexins.
March 5, 2003... 2003 MAR 5 - (NewsRx.com & NewsRx.net) -- According to a study in the United States, "The rat retina contains two types of macroglial cells, Muller cells, radial glial cells that are the principal macroglial cells of vertebrate retinas, and...