Immunotherapy Weekly articles from June 2004

Immunotherapy Weekly archives from June 2004

Disodium cromoglycate inhibits mast cell-mediated allergic reactions.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Disodium cromoglycate (DSCG) shows promise as an anti-allergy agent. In a recent study from South Korea, scientists evaluated the effect of DSCG on "mast cell-mediated immediate-type...

Synthetic androstene analogue ameliorates murine collagen-induced arthritis.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- A novel synthetic androstene analogue ameliorates collagen-induced arthritis in mice. "Dehydroepiandrosterone (DHEA), a precursor of immune-regulating hormones (IRH) including the androstenes, has...

Hepatitis A/B vaccine cost-effective substitute for hepatitis B vaccine.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Substituting the bivalent hepatitis A/B vaccine for the hepatitis B in prisons in the United States would be cost-effective. According to a study from the United States, "Hepatitis B immunization...

Estrogen receptor beta localized to mitochondria.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Estrogen receptor beta is localized to mitochondria. Scientists at the University of North Texas reported, "Estrogen receptors (ERs) are believed to be ligand-activated transcription factors...

Pneumococcal vaccine is immunogenic in ataxia-telangiectasia patients.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- The seven-valent pneumococcal conjugate vaccine elicited an immune response in patients with ataxia-telangiectasia. According to recent research from Germany, "Immune responses to a 7-valent...

CTL ontogeny and viral escape have implications for HIV vaccine design.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Cytotoxic T lymphocyte (CTL) ontogeny and viral escape have implications for HIV vaccine design. According to recent research published in the journal Trends in Immunology, "The protective role of...

Components of HIV vaccine are recognized by T-helper cells.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Minor components of a multi-envelope HIV vaccine are recognized by type-specific T-helper cells. "HIV has thus far evaded control by vaccines, in part due to the high diversity among viral...

IL-15 may be beneficial for AIDS immunotherapy.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Interleukin-15 (IL-15) may be beneficial for AIDS immunotherapy. According to recent research published in the journal Trends in Immunology, "The current antiretroviral therapy has improved the...

Neutralizing antibodies against HIV-1 tat antigen characterized.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Scientists have characterized neutralizing human monoclonal antibodies against human immunodeficiency virus type 1 tat antigen. According to a study from France, "The human immunodeficiency virus...

Role of therapeutic vaccines for the control of HIV-1 reviewed.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Scientists review the role of therapeutic vaccines for the control of HIV-1 in a recent issue of the Journal of Antimicrobial Chemotherapy. According to recent research from England, "The recent...

Virus-like particles rich in HIV-1 envelope gp120 developed.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Researchers have developed virus-like particles rich in HIV-1 envelope gp120. "In order to improve the immunogenicity of HIV-1 envelope glycoproteins, we have fused gp120 to a carrier protein,...

Encouraging data reported from phase I study of asthma/allergy drug.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Avanir Pharmaceuticals (AVN) announced the completion of the initial phase I clinical trial for its experimental asthma/allergy drug, AVP 13358. The study included 54 healthy volunteers and was...

Phase I trial of CRX-675 initiated in patients with seasonal allergic rhinitis.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Corixa Corporation (CRXA), a developer of immunotherapeutics, announced the initiation of a phase I clinical trial to test the safety and immune response activity of CRX-675 for seasonal allergic...

Allergic fungal rhinosinusitis occurs in 6% of chronic rhinosinusitis.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Allergic fungal rhinosinusitis occurs in 6% of chronic rhinosinusitis. "Chronic rhinosinusitis (CRS) is a disease very frequently encountered by otorhino-laryngologists. According to Ponikau et al.,...

Increased atopy caused by development of Th2 immune response to allergens.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Increased atopy may be caused by the development of a Th2 immune response to environmental allergens. "Developed nations are experiencing a marked increase in prevalence of the familial allergic...

Unknown mechanism of action involved in expression of cytokines in mast cells.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- An unknown mechanism of action is involved in the expression of cytokines in mast cells. Scientists in Japan reported, "Olopatadine hydrochloride (olopatadine) is an anti-allergic drug that...

Most household cleaners remove peanut allergens.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Peanut allergy sufferers and their parents take note: A Johns Hopkins Children's Center study finds that most soaps and household cleaners will remove enough peanut allergen from hands and dining...

APP contributes to inflammatory condition in Alzheimer disease.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Amyloid precursor protein contributes to the inflammatory condition in Alzheimer disease. "Alzheimer's disease is a progressive neurodegenerative disorder characterized by extracellular deposition...

Burden of dealing with dementia prompts caregivers to misjudge patient happiness.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Two studies provide new evidence that caring for aging loved ones can take an alarming toll on mind and body. One study finds the burden of caring for an Alzheimer patient can lead to a measurable...

Enhanced iNOS expression associated with progression of CAL in Kawasaki disease.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Enhanced iNOS expression is associated with progression of CAL in Kawasaki disease. "Nitric oxide (NO) serves many vasoprotective roles, but the massive release of NO causes arterial wall...

Patients with moderate thrombocytopenia do not require treatment.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Patients with moderate thrombocytopenia do not require treatment. "To define usefulness and response to therapy and outcome in adults with idiopathic thrombocytopenic purpura (ITP) in clinical...

Hamster model for Chlamydia pneumoniae infection developed.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Scientists have developed a hamster model for Chlamydia pneumoniae infection. "We report that intraperitoneal injection of Chlamydia pneumoniae purified elementary bodies (EBs) in the hamster causes...

Membranal polypeptides of Bacillus anthracis identified.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Scientists have identified chromosomally encoded membranal polypeptides of Bacillus anthracis through a proteomic analysis. "Bacillus anthracis is the causative agent of anthrax disease....

Data: Avelox remains active against bacterial strains.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- North American surveillance data presented at the 14th annual European Congress of Clinical Microbiology and Infectious Diseases showed the antibiotic Avelox (moxifloxacin HCl) was still active against...

Fas-mediated apoptosis enhanced in ageing human keratinocytes.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Fas-mediated apoptosis is enhanced in ageing human keratinocytes. "Cellular senescence and apoptosis are two metabolically related and seemingly synergistic processes that are involved in tissue...

Incidence of chronic lung diseases in children highest in polluted inner cities.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- The incidence of chronic lung diseases in children are the highest in polluted inner cities. "Examination of the current state of health in the United States suggests that childhood lung diseases...

More than 50% of surveyed African-American parents unaware of asthma triggers.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- A recent survey found that less than half of African-American parents with young children in Atlanta, Georgia, and Chicago, Illinois, were aware of the most common triggers of asthma, reported...

Early childhood ear infections linked to asthma.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Children with recurrent ear infections may have an increased risk of developing asthma, according to a new study. Results of the study, published in the May 2004 issue of Chest, showed that...

Chemokines and cytokines expressed in Salmonella-infected chicken hatchlings.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Chemokines and cytokines are expressed in Salmonella-infected chicken hatchlings. Scientists in the U.K. reported, "Poultry meat and eggs contaminated with Salmonella enterica serovar Enteritidis or...

Hedgehog-interacting protein prevents basal cell carcinoma.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Recombinant hedgehog-interacting protein provides immunoprevention of basal cell carcinomas. "Basal cell carcinomas (BCCs) are driven by abnormal hedgehog signaling and highly overexpress several...

Micropatterned hyaluronan surfaces orient lymphatic endothelial cell growth.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Micropatterned hyaluronan surfaces orient lymphatic endothelial cell growth. "The implant of a biocompatible device capable of guiding lymphatic vessel regeneration in patients who underwent removal...

Prestorage plasma filtration activates the complement cascade.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Prestorage plasma filtration activates the complement cascade. According to recent research in Sweden, "Complement activation and generation of pro-inflammatory cytokines occur during storage of...

Protective role of fibulin-1 elucidated.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- The protective role of fibulin-1 (Fbln-1) in breast cancer patients has been elucidated. According to recent research from Italy, Fbln-1 is "an immunogenic breast cancer-related glycoprotein...

Gefitinib and trastuzumab show promise for treatment of metastatic breast cancer.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- The combination of gefitinib and trastuzumab shows promise for the treatment of metastatic breast cancer (MBC). "Despite new therapies and several treatment options," MBC "remains incurable,"...

Flea-borne transmission model evaluates vaccines against bubonic plague.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- A flea-borne transmission model is useful for evaluating vaccine efficacy against naturally acquired bubonic plague. "A flea-to-mouse transmission model was developed for use in testing new...

Company seeks partner for Immunogene therapy for cancer.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- AMDL, Inc., (ADL), developer and marketer of tests for the early detection of cancer and other serious diseases, announced that it has launched a major effort to seek a strategic partner for clinical...

Immunotherapy for cancer: Inflammations open up access to tumors.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Although the immune system potentially recognizes tumor cells as foreign and destroys them, vaccination therapies have so far been disappointing. Malignant tumors seem to establish a special...

Complement function in antibody-mediated cancer immunotherapy described.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Researchers describe complement function in monoclonal-antibody-mediated cancer immunotherapy in a recent issue of Trends in Immunology. "Complement activation by monoclonal antibodies can cause...

Current developments of immunotherapy in the clinic reviewed.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Researchers review current developments of immunotherapy in the clinic According to published research from the United States, "The clinical application of immunotherapy for cancer is rapidly moving...

Heat shock protein 70-pulsed dendritic cells elicit tumor immunity.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Tumor-derived heat shock protein 70-pulsed dendritic cells elicit tumor-specific cytotoxic T lymphocytes (CTLs) and tumor immunity. "Vaccination with autologous tumor-derived heat shock proteins...

Plasmids costimulate DNA vaccine against carcinoembryonic antigen.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Plasmids encoding membrane-bound IL-4 or IL-12 strongly costimulate DNA vaccination against carcinoembryonic antigen (CEA). "Vaccination with plasmids encoding an antigen of interest (DNA...

Tumor-specific antigens are encoded by gene MAGE-C2.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Researchers report two new tumor-specific antigenic peptides that are encoded by gene MAGE-C2 and presented to cytolytic T lymphocytes by HLA-A2. According to a study from Belgium, "We have...

Vaccination against cervical cancer reviewed.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Scientists review vaccines against cervical cancer in a recent issue of Hospital Medicine. According to recent research from Wales, "The link between human papillomavirus (HPV) and cervical cancer...

C-terminal antibody binding domain of C. albicans mp58 is protective.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- The C-terminal antibody binding domain of Candida albicans mp58 represents a protective epitope during candidiasis. "The 58-kDa surface mannoprotein of Candida albicans (mp58) elicits strong...

Abciximab and heparin resolve thrombus on atrial septal occluder.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Abciximab and heparin have been successfully used to resolve a thrombus on an atrial septal occluder. "Acute device thrombosis is a rare but important complication after transcatheter atrial septal...

Infliximab effective against refractory Kawasaki disease.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- The anti-TNF-alpha monoclonal antibody infliximab may be effective against refractory Kawasaki disease (KD) in children. KD is "a multisystem vasculitis of unknown etiology, with coronary artery...

Myocardial ischemia triggers substance P release from spinal cord.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Myocardial ischemia triggers the release of substance P from cardiac afferent spinal neurons, which could underlie the pain of angina. In a recent study from the United States, "[a]ntibody-coated...

MMP3 involved in control of synaptic structure at the neuromuscular junction.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- MMP3 is involved in the control of synaptic structure at the neuromuscular junction. "Matrix metalloproteinases are important regulators of extracellular matrix molecules and cell-cell signaling....

TALL-104 cells injure glioma cells by apoptotic and necrotic pathways.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- TALL-104 cells injure glioma cells by apoptotic and necrotic pathways. "TALL-104 is a human leukemic T cell line that expresses markers characteristic of both cytotoxic T lymphocytes and natural...

Phase III Ampligen trial meets primary endpoint for CFS.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Hemispherx Biopharma, Inc., (HEB) announced that its pivotal phase III chronic fatigue syndrome (CFS) trial of Ampligen met its primary endpoint with patients receiving Ampligen for 40 weeks. A...

Novel C. rodentium type III secreted proteins reduce colon hyperplasia.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Novel Citrobacter rodentium type III secreted proteins reduce hyperplasia in the colon. "Citrobacter rodentium is a member of a group of pathogens that colonize the lumen of the host...

Splicing variants of novel Rnd2 effector Rapostlin induces neurite branching.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Splicing variants of the novel Rnd2 effector Rapostlin induces neurite branching. "Rho family GTPases regulate neuronal morphology. Rnd subfamily is a new branch of Rho family GTPases. Of these...

Agreement signed for humanized antibody to interferon-gamma.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Advanced Biotherapy, Inc., (ADVB) and Innogenetics NV (INNX) announced the signing of a cross-licensing agreement combining Innogenetics' patented humanized antibody to interferon-gamma (known as INNO...

Agreement signed to develop compounds for autoimmune disorders.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- 4SC AG, a German-based drug discovery and development company, and Serono (virt-x: SEO and SRA) announced that they have signed an agreement under which 4SC grants Serono exclusive worldwide rights to...

Mononuclear phagocytes are a vehicle for cryptococcal dissemination.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Mononuclear phagocytes are a vehicle for cryptococcal dissemination. "Secreted phospholipase B (PLB) activity promotes the survival and replication of Cryptococcus neoformans in macrophages in...

Cytokines IL-8 and IL-10 are prognostic factors in burn sepsis.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Cytokines IL-8 and IL-10 are prognostic factors in burn sepsis. Scientists in Turkey report, "Cytokines have been considered as important participants in the post-burn pathophysiological process....

Cytomegalovirus glycoprotein elicits antibody response in macaques.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Rhesus cytomegalovirus glycoprotein B elicits an antibody response in naturally infected rhesus macaques. "Rhesus cytomegalovirus (RhCMV) exhibits strong parallels with human CMV (HCMV) in terms of...

DNA dry powder for non-viral gene delivery prepared by freeze-drying.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- DNA dry powder for non-viral gene delivery can be prepared by spray-freeze drying. According to a study from Taiwan, "This study investigates the feasibility of using the process of spray-freeze...

Artificial antigen presentation reviewed.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Scientists review artificial antigen presentation in a recent issue of Nature Biotechnology. "Artificial antigen presentation aims to accelerate the establishment of therapeutic cellular immunity....

Dendritic cell vaccine efficacy quantified using flow cytometry.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- The protective efficacy of dendritic cell based vaccines in a human papillomavirus type 16 murine challenge model was quantified using flow cytometry. According to recent research published in the...

Pediatric dengue vaccine is cost-effective.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- A pediatric dengue vaccine is cost-effective in Southeast Asia. According to published research from the United States, "To ascertain the economic feasibility of a pediatric tetravalent dengue...

Safety and efficacy of pimecrolimus reviewed.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- The utility of pimecrolimus as a topical anti-inflammatory agent has been reviewed. "Pimecrolimus (SDZ ASM 981, Elidel) is an ascomycin marolactam derivative and a cell-selective inhibitor of...

Cytokine gene expression in diabetes pathogenesis discussed.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- The role of cytokine gene expression in the peritoneal macrophages and splenic CD4- and CD8-positive lymphocytes of nonobese diabetic mice is discussed in a recent issue of the Journal of Clinical...

Maternal immunity to insulin does not affect diabetes risk in progeny.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Maternal immunity to insulin does not affect diabetes risk in progeny of nonobese diabetic mice. "It has been suggested that maternal environment, in particular maternal autoantibodies, modify the...

Compact disk-like microfluidic ELISA platform developed.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- A CD-like microfluidic ELISA platform has been developed. Researchers in the United States devised "an integrated microfluidic device on a compact disk (CD) that performs an enzyme-linked...

Immunonephelometric FLC test useful for monitoring monoclonal gammopathies.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- A novel immunonephelometric assay is useful for monitoring patients with monoclonal gammopathies. "In patients with light-chain myeloma or primary AL-amyloidosis, 24-hr light-chain excretion in the...

MRI enables macrophage monitoring in murine autoimmune neuritis.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- MRI enables monitoring of macrophage activity in murine autoimmune neuritis. Researchers in Germany conducted an "in vivo assessment of macrophage infiltration in adoptive transfer experimental...

Recombinant ELISA highly sensitive and specific for clonorchiasis diagnosis.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Recombinant ELISA is a highly sensitive and specific test for clonorchiasis diagnosis. "We produced a recombinant cysteine proteinase of Clonorchis sinensis and tested its value as an antigen for...

Saliva IgA levels useful for pediatric giardiasis diagnosis.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Saliva immunoglobulin A (IgA) levels can be used in the diagnosis of pediatric giardiasis. In a recent study, scientists in Venezuela "standardized and evaluated an ELISA technique for the detection...

Oral diphtheria vaccine with microparticle adjuvant is immunogenic.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Oral vaccination against diphtheria using polyacryl starch microparticles as adjuvant elicited a strong immune response. "Oral vaccination offers the advantage of eliciting both a mucosal and a...

Anti-tumor activity of dehydrocrotonin and derivatives evaluated.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- The efficacy of natural and synthetic versions of dehydrocrotonin have been evaluated. In a recent study from Brazil, the "anti-tumor properties of dehydrocrotonin and its derivatives were...

Nitric oxide plays protective role in murine encephalomyelitis model.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Nitric oxide plays a protective role in a murine model of encephalomyelitis. According to published research from Germany, "[m]ice with a targeted deletion of the cytokine-inducible nitric oxide...

Somatostatin receptor subtype 2 represents cell differentiation marker in tumors.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Somatostatin receptor subtype 2 may represent a cell differentiation marker in tumors. According to researchers writing in the journal Digestive and Liver Disease, "The presence of cellular...

Vasopressin release reduced in ovariectomy restored by oestradiol replacement.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Vasopressin release reduced in ovariectomy was restored by oestradiol replacement. "The set points for vasopressin release in response to increasing plasma osmolality and hypovolemia alter with...

Caspase-1 mediates Fas-induced apoptosis in human astrocytoma cells.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Caspase-1 mediates Fas-induced apoptosis in human astrocytoma cells. "Resistance to Fas-mediated apoptosis contributes to tumor evasion from the host immune system and enables tumors to mediate...

Trypsin IV is a novel agonist of protease-activated receptors 2 and 4.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Trypsin IV is a novel agonist of protease-activated receptors 2 and 4. "Certain serine proteases signal to cells by cleaving protease-activated receptors (PARs) and thereby regulate hemostasis,...

Actimmune maker reports reduced net losses during first quarter.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- InterMune, Inc., (ITMN) announced results from operations for the first quarter ended March 31, 2004. The company recorded a net loss for the first quarter of 2004 of $11.7 million, or $0.37 per...

Affinitak maker reports decrease in revenues during first quarter.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Isis Pharmaceuticals, Inc., (ISIS) announced its financial results for the first quarter of 2004. The company's revenue for the 3 months ended March 31, 2004, was $12.3 million compared to $14.0...

Antibody-focused pharmaceutical reports $31.0 million in net losses during Q1.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Medarex, Inc., (MEDX) announced its financial results for the 3-month period ended March 31, 2004. During this period, Medarex's net loss was $31.0 million or $0.39 per share as compared to a net...

Diagnostic-device maker reports net loss of $2.2 million in most recent quarter.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Inverness Medical Innovations, Inc., (IMA), a manufacturer and marketer of rapid diagnostic products for the consumer and professional markets, announced its financial results for the quarter ended...

Drugmaker raises $40 million in series D financing.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Microbia, Inc., a privately held biopharmaceutical company discovering and developing small-molecule drugs to treat gastrointestinal disorders, serious fungal infections, and pain and inflammation,...

Net loss reported by developer of humanized antibodies.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Protein Design Labs, Inc., (PDL) reported a net loss of $12.6 million, or $0.13 per basic and diluted share, for the 3 months ended March 31, 2004, compared with net income of $4.1 million, or $0.05 per...

Pharmaceutical company announces first quarter 2004 financial results.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Rigel Pharmaceuticals, Inc., (RIGL) reported financial results for the first quarter ended March 31, 2004. For the first quarter of 2004, Rigel reported a net loss of $13.1 million, or $0.81 per...

Enteral absorption of CsA good in very small children following liver transplant.
June 2, 2004... 2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Enteral absorption of CsA is good in very small children following liver transplant. Scientists from the University of Hamburg reported, "Pharmacokinetic studies in adult and pediatric liver...