Immunotherapy Weekly articles from June 2003

Immunotherapy Weekly archives from June 2003

Counteracting loops explain immune response to hepatitis C virus infection.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- Counteracting loops explain immune response to hepatitis C virus infection. According to published research from England, "Cellular immune responses play an important role in the control of...

Faulty cell-cycle regulation may affect activation of FTY720-mediated apoptosis.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- Research findings suggest that cell-cycle regulator dysfunction may play an important role in the signal transduction pathway for activation of apoptosis mediated by the immunosuppressant, FTY720. ...

Dust mite allergy increases the risk of prostate cancer.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- Breast and lung cancer have no allergy-related association, but dust mite allergy increases the risk of prostate cancer. "The associations among certain allergic disorders, atopy upon skin-prick...

Amphotericin B deoxycholate dose can be escalated in patients with neutropenia.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- Patients with neutropenia can have dosage of amphotericin B doubled if given continuous infusion therapy. According to recent research from the United States, "Amphotericin B deoxycholate (AmB-d)...

Drug treatment successful for lupus-associated insulin resistance.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- Drug treatment with cyclophosphamide and mycophenolate mofetil was successful for treating systemic lupus erythematosus-associated type B insulin resistance syndrome. "Systemic lupus erythematosus...

Predictive value is better by skin prick test than specific IgE antibodies.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- Comparison of the RAST and skin prick tests in terms of predicting hay fever shows that negative results correlate better with lack of hay fever than positive results with symptoms, and that although...

Nebulized adrenaline did not offer a significant advantage in treating infants.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- Nebulized adrenaline did not offer a significant advantage over nebulized saline in treatment of infants with acute bronchiolitis, but more patients in that group were discharged from the hospital...

CD28 is essential for disease formation and should be an immunotherapy target.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- A transgenic mouse model shows that CD28 stimulation is critical for the formation of allergic asthma, and thus CD28 could be a target for immunotherapy. According to a study from the United States,...

Alternaria fungal spores are major cause of symptoms in sensitized children.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- The fungus Alternaria (spores) appears to be responsible for a large proportion of allergic rhinitis symptoms. According to a study from Sweden, "Allergic rhinitis is associated with exposure to...

Hypersaline nasal irrigation works well in seasonal pediatric sufferers.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- Hypersaline nasal irrigation works well in seasonal pediatric allergic rhinitis sufferers. According to recent research published in the journal Pediatric Allergy and Immunology, "Recent evidence...

The serum IL-10/IL-12 ratio and sE-selectin is increased in wheezing infants.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- Wheezing infants and children with skin rash had different levels of serum markers such as IL-10, IL-12, and sE-selectin that appear to be indicative of future allergies. Published research from...

Mutant familial amyloid precursor protein loses apoptosis-inducing property.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- Mutant familial amyloid precursor protein loses the ability to induce stress-related apoptosis; interactions are also altered with SV40 protein. According to recent research from Canada, "The...

Antithymocyte globulin and cyclosporine can lead to Merkel cell carcinoma.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- Antithymocyte globulin and cyclosporine therapy can lead to development of Merkel cell carcinoma. According to published research from Japan, "We report a patient who developed Merkel cell...

Ascorbic acid modifies the surface of asbestos, removing iron and silica.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- Ascorbic acid, a component of human lung lining, breaks asbestos down, releasing iron and silica as products, and may thus be involved in pathogenesis. According to recent research from Italy,...

New research reveals why people do not take medications.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- Social distractions and fear of side effects are two of the main reasons African American adults don't take their asthma medication, according to a study from researchers at the University of...

Antineutrophil cytoplasmic autoantibodies may be related to other diseases.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- Antineutrophil cytoplasmic autoantibodies may be related to diseases other than vasculitis. According to a study from Czech Republic, "Anti-neutrophil cytoplasmic antibodies (ANCA) are mostly known...

Pemphigus vulgaris and tufted hair folliculitis may be linked.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- Pemphigus vulgaris appears to be linked in some way to tufted hair folliculitis. "Tufted hair folliculitis (THF) is a rare disease which is characterized by the emergence of multiple hairs from...

Phase I clinical trials of a second UltiMAb antibody begin.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- Medarex, Inc., (MEDX) announced that its licensee, Novartis Pharma, AG, has commenced phase I clinical trials of a fully human antibody product candidate for the treatment of autoimmune disease. ...

AIRE regulates negative selection of organ-specific T cells.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- Transgenic work shows that mutated human AIRE gene causes a failure in ability to delete organ specific autoantibodies in the thymus, thus elucidating the cause of autoimmune polyendocrinopathy syndrome...

Cicatricial pemphigoid, epidermolysis bullosa can be immunofluorescent-diagnosed.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- Two indirect immunofluorescence techniques are now options available to distinguish cicatricial pemphigoid and epidermolysis bullosa acquisita. According to a study from Netherlands, "Binding of...

Dexamethasone and anti-IgM apoptosis will not occur if Ik-6 is overexpressed.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- Overexpression of Ik-6 appears to confer resistance to apoptosis in 2 different cell lines with differing mechanisms. "In previous studies, we demonstrated an over-expression of the...

Acquired von Willebrand syndrome occurs in some geriatric patients.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- Acquired von Willebrand syndrome is an uncommon bleeding disorder that occurs in old age and may first appear with gastrointestinal bleeding or postoperatively, and can also be associated with...

Chronic graft-versus-host disease rarely gives bullous scleroderma.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- The second case of bullous sclerodermatous graft versus host disease is described resulting from bone marrow transplant. "Cutaneous graft-versus-host disease (GVHD) is the most common clinical...

Lymphoproliferative disorder can have EBV infection in both B and T cells.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- Lymphoproliferative disorder having EBV infection in both B and T cells can occur as a result of bone marrow transplant. "Post-transplantation lymphoproliferative disorder (PTLD) is usually an...

Glial cells protect against LPS-induced blood-brain barrier permeabilization.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- LPS endotoxin causes paracellular permeability of blood brain barrier; glial cells prevent the process. According to recent research from France, "Numerous infections of the central nervous system...

Protective effect against future pediatric allergies can be lowered by chemicals.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- The amount of breast feeding protection against atopy may be lowered by the level of breast milk contaminants. "Despite the numerous studies on the possible protective effect of breast feeding...

Pneumococcal pneumolysin has cytolytic and complement-activating activities.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- Mutation studies of Streptococcus pneumoniae toxin pneumolysin show that it has 2 activities: complement activation and cytolysis. According to recent research published in the journal Infection...

TNF-alpha production induced from human monocytes by beta-1,3-glucan oligomer.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- A beta-1,3-glucan oligomer from laminarin induces tumor necrosis factor (TNF)-alpha production from human peripheral blood monocytes, Nagasaki University scientists demonstrated. "We prepared a...

Calcitriol launched for hypocalcemia.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- American Pharmaceutical Partners, Inc., (APPX) announced the launch of calcitriol for injection with shared 180-days of marketing exclusivity. Calcitriol, the generic equivalent of Abbott Laboratories,...

Western blot is the most sensitive and specific method for detection in neonates.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- Western blot is the most sensitive and specific method for detection of toxoplasmosis in neonates. "The goal of the study reported here was to compare the results of Western blot with other...

Protein-losing enteropathy may possibly be caused by complement activation.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- Cryoglobulinemia can be associated with protein losing enteropathy, possibly caused by complement activation. According to a study from Greece, "We describe a case of protein-losing enteropathy in...

Th2 response occurs early in infection, Th1 follows with reduction in parasites.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- Th1 response and a drop in the number of Leishmania guyanensis only follows a Th2 response with increased numbers of parasites. "Intralesional Th2 responses preceded the development of Th1...

Transcriptional factor Id2 functions to suppress B cell genes.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- The transcription factor Id2 is induced by TGF-beta and is involved in repression of B cell genes, thus it is involved in lineage determination. "Dendritic cells (DCs) are potent antigen-presenting...

CD1a-negative dendritic cells can be created from blood with a pinecone extract.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- Differentiation into CD1a-negative dendritic cells in the absence of cytokines is possible with a pinecone extract. According to recent research published in the journal International...

Intramedullary histoplasmosis spinal cord abscess can cause paraplegia.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- Intramedullary histoplasmosis can cause paraplegia; it can be treated by surgery of abscess and antifungal agents. According to a study from the United States, "An immunocompetent patient from a...

Palpebral edema can be a cutaneous manifestation of hyperthyroidism.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- Unilateral eyelid edema may be related to hyperthyroidism. "Three cases of palpebral edema associated with Graves disease are described. These patients had unilateral edema and minimal erythema of...

Distinguishing virus-specific T cells can be done with peptide-HLA-GFP complexes.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- Circulating HTLV-I specific T cells can be identified by uptake of peptide-HLA-green fluorescent protein complexes. According to recent research from the United States, "Antigen-specific CD8+ T...

The virulence gene cagA and MUC2 mucin are linked with cancer risk.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- Helicobacter pylori cag A virulence gene is upregulated in precancerous and cancerous lesions, and these lesions specifically produce the MUC2 mucin. "Gastric intestinal metaplasia (IM) and gastric...

Surgery to repair abdominal aortic aneurysm can have long-term success.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- Despite many complicating factors, abdominal aortic aneurysm surgery can successfully be performed on dialysis patients. "Abdominal aortic aneurysm repair in patients undergoing chronic...

Vaccination against hepatitis A elicits humoral and cellular immune responses.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - Vaccination against hepatitis A stimulates release of both interferon-gamma and interleukin-10, according to a report in Pharmacotherapy. Mary S....

Data presented on next CoVal fusion in pipeline targeting HBV.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- Stressgen Biotechnologies Corp. (SSB) presented its latest preclinical research results at the 6th annual Conference on Vaccine Research on its new CoVal fusion compound, HspBcor, designed to treat...

TNF-receptor associated periodic syndrome may be treatable with TNF receptors.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- TNF-receptor associated periodic syndrome (TRAPS) may be treatable with recombinant TNF receptor analogs. According to a study from France, "Hereditary periodic fever syndromes are defined as...

Cutaneous B-cell pseudolymphoma is a recurrent risk years after antigen therapy.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- Cutaneous B-cell pseudolymphoma has a risk of recurrence and dissemination years after intradermal antigen therapy. Recent research published in the Journal of the European Academy of Dermatology...

Kinetics, gene regulation in lymphocyte polarization to Th1 & Th2 cells studied.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- According to a study in the European Journal of Immunology, "Many genes implicated in Th1 and Th2 differentiation have been identified in both human and mouse. However, the functional roles and...

MHCBN, available on the internet, has MHC binding and non-binding peptide data.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- There is a comprehensive database available for finding proteins that bind or not to MHC. According to a study from India, "MHCBN is a comprehensive database of Major Histocompatibility Complex...

New FOCIS centers to advance clinical research on a global scale.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- A new international outreach effort, developed by the Federation of Clinical Immunology Societies (FOCIS), will assist institutions throughout the world that focus on clinical immunology to provide...

Immunotherapy does not prevent or reverse diabetic lumbosacral plexopathy.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- Immunotherapy did not prevent or reverse diabetic lumbosacral plexopathy. "Three patients are described who had severe and progressive diabetic lumbosacral plexopathy despite active...

Experts examine global progress in vaccines.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- Many of the world's vaccine scientists met at the National Foundation for Infectious Diseases' (NFID) Sixth Annual Conference on Vaccine Research to present the latest research on vaccines against...

Lipoxins work towards resolution of intestinal and other inflammations.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- Naturally occurring and synthetic lipoxins are responsible for attenuation of the inflammatory response. "Many inflammatory processes are self-limiting, suggesting the existence of endogenous...

Immunology a dominant force in revolutionizing fight against immune-mediated disorders.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- A growing consensus among doctors and scientists that seemingly unrelated diseases actually share common pathways was a key topic for the nearly 3,500 scientists and medical researchers who met in...

Nasal vaccine delivery platform data presented at vaccine conference.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- Carrington Laboratories, Inc., (CARN) announced that results of an initial study sponsored by its subsidiary DelSite Biotechnologies, Inc., were presented at the 6th Annual Conference of Vaccine...

Coronary artery inflammation is a high risk for babies with low serum albumin.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- Kawasaki disease patients are all at risk for coronary artery inflammation, but if they are less than 1 yr old and have low serum albumin, they have a very high risk. "The objective of this study...

Immunoglobulin failure and retreatment can occur in anemic pediatric patients.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- About 10% of pediatric Kawasaki disease patients require retreatment by immunoglobulins due to failure. "Several cases of Kawasaki disease (KD) were unresponsive to the initial treatment with...

Mannose-binding lectin mutation is linked with cardiovascular lesions in babies.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- In children "Kawasaki disease is an acute vasculitis of possible infectious cause, which in particular affects the coronary arteries. Young children rely mostly on their innate immune system for...

Percentage of liver remaining is predictive of degree of hepatic function.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- The percentage of liver remaining in hepatic resection is predictive of risk relating to hepatic function and length of hospital stay. According to a study from the United States, "Liver-enhancing...

Pediatric patients will require monitoring of mycophenolic acid levels.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- In pediatric liver transplant recipients, the levels of mycophenolic acid must be monitored, but coadministration with cyclosporine A will require larger doses than with tacrolimus. According to...

Coexposure with magnetic fields and vinblastine increases effect on lymphocytes.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- Low frequency magnetic fields can increase cell proliferation in normal lymphocytes and even enhances micronucleus and apoptosis frequency in lymphocytes given vinblastine. "Interference of 50 Hz,...

Antibodies to VlsE IR6 can persist years after successful antibiotic treatment.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- Antibody response to VlsE IR6 peptide of Borrelia burgdorferi after successful antibiotic treatment is not indicative of actual disease; the antibody response can persist for years. According to...

ELISPOT is a very useful method for T cell epitope mapping.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- ELISPOT is a very useful method for T cell epitope mapping, and this paper describes how to use it in that context. According to a study from the United States, "The ELISPOT assay is particularly...

Food intolerance is most often the cause of pain.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- Pediatric migraine is often the product of food intolerance, and treatment should address this issue first. "Diet can play an important role in the precipitation of headaches in children and...

The origin of blood meals can help epidemiological tracking, using PCR.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- The species origin of mosquito blood meals is beginning to be trackable. According to published research from the United States, "A PCR protocol was developed to identify host blood meals from...

Immune cells may help deliver cancer vaccines for children.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- In a finding that could lay the groundwork for future cancer vaccines for children, cancer researchers working in cell culture have shown that modified immune cells can efficiently deliver genetic...

Nonepisodic autosomal dominant spinocerebellar ataxias have different mechanisms.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- Nonepisodic autosomal dominant spinocerebellar ataxias have different mechanisms, one of which is missense mutation in protein kinase C gamma regulatory domain. According to a study from the United...

Isolated fetal ascites must include consideration of Wolman disease.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- Fetal ascites can be caused by Wolman disease and should be considered along with other possible causes before birth. According to recent research from Israel, "Wolman disease is a rare...

Depo-medrol reduced prostaglandin E2 after injection in irreversible pulpitis.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- Pulpal concentrations of prostaglandin E2 were reduced the day after depo-medrol injection in emergency patients with irreversible pulpitis. "The purpose of this prospective, randomized,...

Neonatal skin blistering was induced by IgG4 autoantibodies to desmoglein 3.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- Neonatal pemphigus was induced by IgG4 autoantibodies to desmoglein 3. According to recent research from Germany, "We report a case of neonatal pemphigus vulgaris presenting with skin lesions on the...

Helicobacter pylori vacuolating toxin is now expressible in E. coli.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- The Helicobacter pylori vacuolating toxin is now expressible in E. coli. According to recent research published in the journal Infection and Immunity, "VacA is a secreted toxin that plays a role in...

Bordetella pertussis protein pertactin induces immune response.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- The Bordetella pertussis protein pertactin induced type-specific antibodies. "Divergence has been found between Bordetella pertussis vaccine strains and circulating strains. Polymorphism in...

Simultaneous liver-kidney transplant from a living related donor is best.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- Primary hyperoxaluria can be normalized with the least complications by living related liver-kidney transplant. According to recent research from Turkey, "Primary hyperoxaluria type 1 (PH1) is a...

The S100A7 or psoriasin gene is duplicated 5 times in humans.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- The only S100 genes duplicated in humans are five S100A7-like duplicates (psoriasin gene). According to a study from Australia, "The human S100 gene family encodes the EF-hand superfamily of...

Respiratory symptoms like pneumonia are common; can be treated with macrolides.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- Q fever most often presents as pneumonia or other respiratory problems and is resolved by macrolide therapy. According to recent research from Spain, "Sixty-six cases of Q fever in adults,...

Peroral TAS-202 reduces vessel density in models of adjuvant-induced arthritis.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- Peroral TAS-202 reduces vessel density in models of adjuvant-induced arthritis. According to published research from Japan, "the present study was designed to investigate blood vessel density...

Survey: Nasal congestion often treated with the inappropriate medication.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- Studies have shown that nasal congestion is the most bothersome symptom of allergic rhinitis, and according to a new survey, 60% of nasal allergy sufferers agree that nasal congestion is their most...

Antiviral medicine sent to Chinese Hospitals for testing.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- Randy Powers, president of Liddell Laboratories announced that the first shipment of its new antiviral medicine designed for SARS patients will arrive in China and Hong Kong this week for clinical...

Helicobacter pylori infection is more common in sleep apnea patients.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- Helicobacter pylori infection is more common in patients with obstructive sleep apnea. A study from Turkey "investigated the seroprevalence of Helicobacter pylori in patients with obstructive sleep...

Smoking rates in adults with asthma exceed national average.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- Cigarette smoking is more prevalent in adults with acute asthma than in adults without asthma, says a new study. The study found that 35% of adults seeking emergency medical care for asthma...

Allografts effective against chronic granulomatous disease.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- Allogeneic stem cell transplantation is effective against chronic granulomatous disease (CGD). According to published research from Italy, CGD "is a rare primary immunodeficiency caused by an...

Anti-phospholipid syndrome patients have anti-plasminogen autoantibodies.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- Systemic lupus erythematosus patients with anti-phospholipid antibody syndrome have IgG anti-plasminogen that also reacts with human fibrinogen. According to a study from Russia, "Blood plasma...

Antitopoisomerase I antibody found in lupus patients without scleroderma.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- Antitopoisomerase I antibodies were found in two lupus patients without concomitant scleroderma. According to recent research published in the journal Clinical Rheumatology, "We describe two female...

NDA to be submitted for Riquent.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- La Jolla Pharmaceutical Company (LJPC) announced that based on discussions with the U.S. Food and Drug Administration (FDA), the company plans to submit a New Drug Application (NDA) for its lupus drug...

CD28 acts in 2 different ways, dependent on cis and trans conformation.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- CD28 in trans can signal independently via VAV and SLP-76 as a costimulator or interact with the TCR directly in cis. According to a study from England, "The 2-signal theory of T-cell activation...

Short-term, high-dose cyclosporin may be useful in pediatric refractory disease.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- Pediatric patients with refractory chronic idiopathic thrombocytopenia purpura may be treatable with cyclosporin A. According to a study from Italy, "We report on 14 children (7 boys, 7 girls) with...

Frequency of micronuclei changes based on tobacco use and genotoxic exposure.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- Frequency of lymphocyte micronuclei changes is based on the amount of tobacco use and genotoxic agent exposure. "The effect of tobacco smoking on the frequency of micronuclei (MN) in human...

Chronic graft-versus-host disease improves outcome against multiple myeloma best.
June 4, 2003... 2003 JUN 4 - (NewsRx.com & NewsRx.net) -- Graft versus host disease can be beneficial, as chronic disease improves outcome in multiple myeloma transplant cases. According to published research from Spain, "The outcome of 29 multiple...