Immunotherapy Weekly articles from June 1999

Immunotherapy Weekly archives from June 1999

Peptide-Pulsed PBMC is an Effective Melanoma Vaccine.
June 14, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Immunization with Mage3 or Melan-A peptide-pulsed autologous peripheral blood mononuclear cells (PBMC) plus recombinant human interleukin-12 (RhIL-12) makes an effective vaccination. Thomas F....

Radioimmunotherapy Socks Non-Hodgkin's Lymphoma.
June 14, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Radioimmunotherapy sends 850-fold greater radiation dose to tumor cells, sparing normal organs. G.A. Wiseman, representing colleagues from several institutions from Illinois, California,...

Only Mature RSV Envelope Elicits Neutralizing Abs.
June 14, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Subunit vaccines for respiratory syncytial virus (RSV) must use the mature form of the immunodominant protein in the viral envelope, new studies show. RSV is the leading viral cause of major...

"Berlin Patient" Case Points To Promise of "New HAART" Regimens to Treat HIV.
June 14, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Long-term control of HIV may be achievable through the use of new highly active antiretroviral therapy ("new HAART") regimens, as noted in a report in the May 27, 1999, issue of the New England...

For 15 years, Research Group Has Been at Forefront of AIDS.
June 14, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- To the gay men they sought for blood samples, the University of Pittsburgh researchers in Pennsylvania were known as the "vampires," people who lurked in the basements and back rooms of bars with...

Aged Thymus Has Potential To Rebuild HIV Ravaged Immune System.
June 14, 1999... (CW HENDERSON PUBLISHER www.newsfile.com) -- Until now, scientists believed that the human thymus - the organ that produces the immune system's infection-fighting T cells - stopped functioning after puberty. Now, in a paper published by...

Systemic Immunotherapy of Advanced Prostate Cancer (CaP): Preliminary Results of a Phase I Clinical Trial Using Recombinant Vaccina Virus Encoding Human MUC-1 and Interleukin-2 (IL-2) Genes.
June 14, 1999... Cancer Vaccines "Systemic Immunotherapy of Advanced Prostate Cancer (CaP): Preliminary Results of a Phase I Clinical Trial Using Recombinant Vaccina Virus Encoding Human MUC-1 and Interleukin-2 (IL-2) Genes." Arndt van Ophoven, Cho-Lea...

Hepatitis C Transgenic Mice as Model of Liver Injury.
June 14, 1999... Animal Models (HCV) "Hepatitis C Transgenic Mice as Model of Liver Injury." Emmett V. Schmidt. Massachusetts General Hospital, 32 Fruit Street, Boston, Massachusetts 02114. (CW HENDERSON PUBLISHER www.newsfile.com) -- NIH GRANT NUMBER:...

Anti-Idiotypic Antibody Vaccination in Conjunction with Intensive Therapy (IT) and Autologous Stem Cell Transplantation (ASCT) for Patients (PTS) with Metastatic Breast Cancer (MBC).
June 14, 1999... Cancer Vaccines "Anti-Idiotypic Antibody Vaccination in Conjunction with Intensive Therapy (IT) and Autologous Stem Cell Transplantation (ASCT) for Patients (PTS) with Metastatic Breast Cancer (MBC)." D. Reece, K. Foon, R. Ceriani, M....

Vaccination of High Risk Breast Cancer Patients (pts) Lacking Identifiable Disease with GN12-Keyhole Limpet Hemocyanin (KLH) Conjugate Plus QS21.
June 14, 1999... Cancer Vaccines "Vaccination of High Risk Breast Cancer Patients (pts) Lacking Identifiable Disease with GN12-Keyhole Limpet Hemocyanin (KLH) Conjugate Plus QS21." T. Gilewski, L. Norton, A. Houghton and R. Israel. Memorial...

Influence of Immunonutrition on Transplant Success.
June 14, 1999... Immunonutrition "Influence of Immunonutrition on Transplant Success." J.W. Alexander. University of Cincinnati, Cincinnati, Ohio 45221. (CW HENDERSON PUBLISHER www.newsfile.com) -- NIH GRANT NUMBER: 1R03AI42743-01. GRANT EXPIRES:...

New Bifunctional Chelating Agents for Radioimmunotherapy with Radiometals.
June 14, 1999... Radioimmunotherapy (Cancer) "New Bifunctional Chelating Agents for Radioimmunotherapy with Radiometals." Donald J. Buchsbaum. University of Alabama at Birmingham, Birmingham, Alabama. (CW HENDERSON PUBLISHER www.newsfile.com) -- NIH...

Treating Allergic Rhinitis in Pregnancy - Safety Considerations.
June 14, 1999... Allergy Medicine Mazzotta, P.; Loebstein, R.; Koren, G. "Treating Allergic Rhinitis in Pregnancy - Safety Considerations." Drug Safety, April 1999;20(4):361-375. (CW HENDERSON PUBLISHER www.newsfile.com) -- According to the authors'...

Utilization and Cost of Immunotherapy for Allergic Asthma and Rhinitis.
June 14, 1999... Allergy Medicine Donahue, J.G.; Greineder, D.K.; Connorlacke, L.; Canning, C.F.; Platt, R. "Utilization and Cost of Immunotherapy for Allergic Asthma and Rhinitis." Annals of Allergy Asthma & Immunology, April 1999;82(4):339-347. (CW...

Fast and Simple Purification of Chemically Modified Hammerhead Ribozymes Using a Lipophilic Capture Tag.
June 14, 1999... Hammerhead Ribozymes Sproat, B.S.; Rupp, T.; Menhardt, N.; Keane, D.; Beijer, B. "Fast and Simple Purification of Chemically Modified Hammerhead Ribozymes Using a Lipophilic Capture Tag." Nucleic Acids Research, April 15,...

A Randomized, Multicenter Comparison of Tacrolimus and Cyclosporine Immunosuppressive Regimens in Cardiac Transplantation: Decreased Hyperlipidemia and Hypertension With Tacrolimus.
June 14, 1999... Heart Transplantation Taylor, D.O.; Barr, M.L.; Radovancevic, B.; Renlund, D.G.; Mentzer, R.M.; Smart, F.W.; Tolman, D.E.; Frazier, O.H.; Young, J.B.; Vanveldhuisen, P. "A Randomized, Multicenter Comparison of Tacrolimus and Cyclosporine...

Anti-LFA-1 alpha Reduces the Dose of Cyclosporin A Needed To Produce Immunosuppression in Heterotopic Cardiac Transplanted Rats.
June 14, 1999... Heart Transplantation Harrison, P.C.; Madwed, J.B. "Anti-LFA-1 alpha Reduces the Dose of Cyclosporin A Needed To Produce Immunosuppression in Heterotopic Cardiac Transplanted Rats." Journal of Heart and Lung Transplantation, April...

Generation of Monoclonal Antibodies to Native Human Immunodeficiency Virus Type 1 Envelope Glycoprotein by Immunization of Mice With Naked RNA.
June 14, 1999... Monoclonal Antibodies Giraud, A.; Atamanonal, Y.; Battail, N.; Piga, N.; Brand, D.; Mandrand, B.; Verrier, B. "Generation of Monoclonal Antibodies to Native Human Immunodeficiency Virus Type 1 Envelope Glycoprotein by Immunization of Mice...

Cellular and Humoral Immune Responses to MUC1 Mucin and Tandem-Repeat Peptides in Ovarian Cancer Patients and Controls.
June 14, 1999... Ovarian Cancer Snijdewint, F.G.M.; Vonmensdorffpouilly, S.; Karuntuwanamarta, A.H.; Verstraeten, A.A.; Vanzantenprzybysz, I.; Hummel, P.; Nijman, H.W.; Kenemans, P.; Hilgers, J. "Cellular and Humoral Immune Responses to MUC1 Mucin and...

Diagnostic OvaRex(TM)-MAb-B43.13 Has Therapeutic Properties.
June 28, 1999... (CW Henderson Publisher www.newsfile.com) -- The monoclonal antibody (MAb) OvaRex(TM)-MAb-B43.13, which has been used for immunoscintigraphic diagnostics, has immune-modulating effects in ovarian cancer patients. The MAb...

High Metastatic Ability Associated With Resistance to TNF.
June 28, 1999... (CW Henderson Publisher www.newsfile.com) -- Highly metastatic cancers are resistant to the immunomodulating cytokine tumor necrosis factor (TNF). E.V. Korobko and colleagues from the Russian Academy of Science, Moscow, investigated the...

Tumor-Associated Fibroblasts Influence Immune Response.
June 28, 1999... (CW Henderson Publisher www.newsfile.com) -- Tumor-activated myofibroblasts prevent immune cells from attacking cancer cells. B. Lieubeau and colleagues from the Institute of Biology, INSERM, France, sought to elucidate the role of...

Warning! The Herceptin MAb is Expressed in Liver Tissue.
June 28, 1999... (CW Henderson Publisher www.newsfile.com) -- The monoclonal antibody (MAb) that recognizes erbB2 is expressed in normal liver tissue. erB2 is the MAb used in the novel and exciting new breast cancer treatment Herceptin. Herceptin has...

Immunotherapy Not As Effective In Children.
June 28, 1999... (CW Henderson Publisher www.newsfile.com) -- Children with severe pediatric Guillain-Barre syndrome (GBS) do not respond as well as adults to immunotherapy. W.D. Graf and colleagues from the Children's Hospital in Seattle, Washington,...

Sweet New Antigen for Staph Vaccines.
June 28, 1999... (CW Henderson Publisher www.newsfile.com) -- A sugar produced by Staphylococcus aureus is sweet news to vaccine researchers. The sugar is the surface polysaccharide poly-N-succinyl (beta)-1-6 glucosamine or PNSG. It is produced only during...

Ex Vivo Treatment of Donor T Cells Induces Anergy to Recipient Alloantigens.
June 28, 1999... (CW Henderson Publisher www.newsfile.com) -- Leukemia patients received donor bone marrow that was treated ex vivo to induce anergy to recipient alloantigens. Successful allogeneic bone marrow transplantation relies on global...

Drug Combinations for Chronic HCV Evaluated.
June 28, 1999... (CW Henderson Publisher www.newsfile.com) -- Combining interferon therapy with either ursodeoxycholic acid or nonsteroidal anti-inflammatory drugs does not appear to improve treatment for chronic hepatitis C virus. Other drug combinations,...

IFN/Ribavirin Combo Useful in HCV/HIV Coinfected Patients.
June 28, 1999... (CW Henderson Publisher www.newsfile.com) -- Combining alpha interferon with ribavirin may improve the therapeutic outcome of patients coinfected with chronic hepatitis C virus and HIV, but further study is needed to confirm this treatment...

Immune Therapy Flushes HIV Out of Hiding.
June 28, 1999... (CW Henderson Publisher www.newsfile.com) -- Researchers said they had struck another blow against HIV, although they stressed they have not cured anybody yet. They said they had teased out one of the hiding places of the virus, allowing...

Vaccine Study Yields Positive Findings.
June 28, 1999... (CW Henderson Publisher www.newsfile.com) -- A vaccine to treat brain cancer has shown promising results in preliminary studies at the University of California Los Angeles (UCLA) Jonsson Cancer Center. A cover-story article published in the...

Study Casts Doubt on Use of Weak HIV as Vaccine.
June 28, 1999... (CW Henderson Publisher www.newsfile.com) -- Three people infected with a weak form of HIV more than 14 years ago have begun to show signs of immunological damage, reducing hope that such HIV strains could be used to develop AIDS vaccines, a...

Ginseng Treatment Enhances Immune System.
June 28, 1999... (CW Henderson Publisher www.newsfile.com) -- Experiments on rats showed that ginseng treatment stimulates the function of phagocytes (part of the immune defense system) to clear bacterial infection more effectively. The results provide...

Preliminary Results of ALVAC-CEA-B7 Phase I Vaccine Trial in Patients with Metastatic CEA-Expressing Tumors.
June 28, 1999... Cancer Vaccines "Preliminary Results of ALVAC-CEA-B7 Phase I Vaccine Trial in Patients with Metastatic CEA-Expressing Tumors." David S. Lee, William Conkright, Heidi E. Horig, Henry Hasson, David S. Park, Vickie Stockdale and Howard L....

Concomitant Use of Autologous Tumor Vaccine and Autologous Stimulated Immune Serum from Co-Culture To Treat Refractory Solid Tumor.
June 28, 1999... Cancer Immunotherapy "Concomitant Use of Autologous Tumor Vaccine and Autologous Stimulated Immune Serum from Co-Culture To Treat Refractory Solid Tumor." K. Alonso, R. Page, G. Kindness and J. McLaren. Institute Advanced Studies in...

Treatment of Ovarian Cancer with Autologous, Hapten-Modified Tumor Cell Vaccine.
June 28, 1999... Cancer Vaccines (Ovarian) "Treatment of Ovarian Cancer with Autologous, Hapten-Modified Tumor Cell Vaccine." David Berd, John Carlson, Ellen Bloome and Charles Dunton. Thomas Jefferson University, Philadelphia, Pennsylvania. (CW...

Effect of a Th2-Bias on Malarial Immunity in Cameroon.
June 28, 1999... Malaria "Effect of a Th2-Bias on Malarial Immunity in Cameroon." Diane W. Taylor. Georgetown University, 37th and O Sts NW, Washington, DC 20057. (CW Henderson Publisher www.newsfile.com) -- NIH GRANT NUMBER: 1U01AI43888-01. GRANT...

HCV Specific Cytotoxic T-Cell Response in Patients and Transgenic Mice.
June 28, 1999... Pathogenesis (HCV) "HCV Specific Cytotoxic T-Cell Response in Patients and Transgenic Mice." B. Rehermann. Current affiliation unavailable. (CW Henderson Publisher www.newsfile.com) -- NIH GRANT NUMBER: 1Z01DK54509-01. PRINCIPLE...

Liposome S Mutans Delivery System for Caries Immunity.
June 28, 1999... Vaccine Development "Liposome S Mutans Delivery System for Caries Immunity." Noel K. Childers. University of Alabama at Birmingham, Birmingham, Alabama. (CW Henderson Publisher www.newsfile.com) -- NIH GRANT NUMBER: 5R01DE09846-07....

An Antigen-Targeted Approach to Adoptive Transfer Therapy of Cancer.
June 28, 1999... Cancer Immunotherapy Valmori, D.; Pittet, M.J.; Rimoldi, D.; Lienard, D.; Dunbar, R.; Cerundolo, V.; Lejeune, F.; Cerottini, J.C.; Romero, P. "An Antigen-Targeted Approach to Adoptive Transfer Therapy of Cancer." Cancer Research, May 1,...

Stealth Monensin Liposomes as a Potentiator of Adriamycin in Cancer Treatment.
June 28, 1999... Drug Resistance Singh, M.; Ferdous, A.J.; Jackson, T.L. "Stealth Monensin Liposomes as a Potentiator of Adriamycin in Cancer Treatment." Journal of Controlled Release, May 1, 1999;59(1):43-53. (CW Henderson Publisher www.newsfile.com)...

Interferon-alpha Plus Ribavirin in Chronic Hepatitis C Resistant to Previous Interferon-alpha Course: Results of a Randomized Multicenter Trial.
June 28, 1999... Drug Resistance (HCV) Andreone, P.; Gramenzi, A.; Cursaro, C.; Sbolli, G.; Fiorino, S.; Digiammarino, L.; Miniero, R.; Derrico, A.; Gasbarrini, G.; Bernardi, M. "Interferon-alpha Plus Ribavirin in Chronic Hepatitis C Resistant to Previous...

Antimalarial Drug Resistance and Combination Chemotherapy.
June 28, 1999... Malaria (Treatment) White, N. "Antimalarial Drug Resistance and Combination Chemotherapy." Philosophical Transactions of the Royal Society of London Series B - Biological Sciences, April 29, 1999;354(1384):739-749. (CW Henderson...

In vivo and in vitro Characterizations of Three Tc-99m-Labeled Monoclonal Antibody G250 Preparations.
June 28, 1999... Monoclonal Antibodies Steffens, M.G.; Oosterwijk, E.; Kranenborg, M.H.G.C.; Manders, J.M.B.; Debruyne, F.M.J.; Corstens, F.H.M.; Boerman, O.C. "In vivo and in vitro Characterizations of Three Tc-99m-Labeled Monoclonal Antibody G250...

Paracrine Immunotherapy With Interleukin-2 and Local Chemotherapy Is Synergistic in the Treatment of Experimental Brain Tumors.
June 28, 1999... Paracrine Immunotherapy Sampath, P.; Hanes, J.; Dimeco, F.; Tyler, B.M.; Brat, D.; Pardoll, D.M.; Brem, H. "Paracrine Immunotherapy With Interleukin-2 and Local Chemotherapy Is Synergistic in the Treatment of Experimental Brain Tumors."...

Clinical Efficacy and Immunological Effects of Weekly Administration of Interferon-beta in Patients With Type B Chronic Hepatitis.
June 28, 1999... Therapy (HBV) Katayama, K.; Hayashi, N.; Ito, T.; Masuzawa, M.; Kishida, Y.; Yoshihara, H.; Akeyama, T.; Shimizu, Y.; Moriyama, M.; Kasahara, A.; Fusamoto, H.; Kamada, T. "Clinical Efficacy and Immunological Effects of Weekly...