Immunotherapy Weekly articles from June 1998

Immunotherapy Weekly archives from June 1998

Years Bring Experience to High Dose IL-2 Therapy for Cancer Patients.
June 8, 1998... High dose interleukin-2 (IL-2) can be safely administered to metastatic cancer patients. Researchers from the U.S. National Cancer Institute (NCI)/National Institutes of Health (NIH), Bethesda, Maryland, treated a consecutive series of 1241...

Allovectin-7 Cancer Gene Therapy Completes Phase II Studies.
June 8, 1998... A phase II study showed that Allovectin-7 cancer gene therapy for metastatic malignant melanoma was safe and induced clinically significant tumor regression. Researchers from several clinical centers participated in phase I/II studies of...

Antibody Therapy Makes Waves in Clinical Trials.
June 8, 1998... Iodine-131 anti-B1 antibody safely and effectively produced high response rates in a clinical trial involving non-Hodgkin's lymphoma (NHL) patients. Researchers from the University of Nebraska Medical Center conducted a meta-analysis of data...

Poor Results Send Researchers Looking Elsewhere.
June 8, 1998... All-trans retinoic acid (ATRA), with or without (alpha) interferon (IFN), was inactive against squamous cell carcinoma (SCC) in a clinical trial. Researchers from the Institut Gustave-Roussy and the Roche Company, France, conducted a...

Rituximab/(alpha)Interferon Combination Immunotherapy Trial Completed.
June 8, 1998... The combination of Rituximab and alpha interferon ((alpha)IFN) can be safely given to low-grade or follicular (LG/F) non-Hodkin's lymphoma (NHL) patients. Researchers from Stanford University Medical Center, California, the Fred Hutchinson...

Memory Cells May Promote Their Own Infection by HIV.
June 8, 1998... A normal cell-surface enzyme may pave the way for HIV to destroy immunologic memory. The finding provides an explanation for the selective loss of memory T cells during HIV infection. It may also provide clues to the development of an AIDS...

Vitamin Increases T-Cell Counts.
June 8, 1998... A pilot study suggests that a vitamin-like agent - in the absence of any other therapy - can reverse T-cell declines in patients with asymptomatic HIV infection. Eight of the 11 patients in the study had increased CD4 counts after four months...

Vaccinated Mice Reject Established Tumors.
June 8, 1998... A fusion-cell vaccine could cause the body to reject tumors, animal studies suggest. The vaccine is made up of fusion cells (FC) created by combining the nuclei of carcinoma cells and dendritic cells. Dendritic cells (DC) are the body's chief...

Many Hurdles for Successful Combination Vaccines.
June 8, 1998... It's more than just mixing. Combinations of existing vaccines are more than the sum of their parts: they are complex new vaccine entities. Developers wishing to take advantage of the trend toward combination vaccines must make similarly...

Patients Lacking IL-12 or With Reduced Levels Are Susceptible to Infections.
June 8, 1998... Researchers have identified a previously unknown kind of human genetic immunodeficiency which renders people susceptible to infection by mycobacteria and Salmonella, but not other pathogens. F. Altare and colleagues from France, Sweden, the...

Optimism in the Face of Stressful Situations Affects Immune System.
June 8, 1998... While research has tied optimism to better coping and disease course with health challenges such as surgery and AIDS, a new study is the first relating optimism to immune change in a healthy population. According to research published in the...

A Phase II Study of Daily Subcutaneous (SQ) Low Dose Interleukin-2 (IL-2), In HIV Associated Malignancies.
June 8, 1998... "A Phase II Study of Daily Subcutaneous (SQ) Low Dose Interleukin-2 (IL-2), In HIV Associated Malignancies." Z.P. Bernstein, G. Barresi, M. Gould, S. Jacob, B. Polesz, P. Curtin and M. Caliguiri. Roswell Park Cancer Institute, Buffalo, New York;...

Immune Response to Orthotopically Injected Pancreatic Tumor Cells.
June 8, 1998... "Immune Response to Orthotopically Injected Pancreatic Tumor Cells." K. Morikane and M.A. Hollingsworth. Eppley Institute, University of Nebraska Medical Center, Omaha, Nebraska. According to an abstract submitted by the authors to the 89th...

Rat Glioma Model of Active Immunotherapy against Mutated Epidermal Growth Factor Receptor (mEGF-R).
June 8, 1998... "Rat Glioma Model of Active Immunotherapy against Mutated Epidermal Growth Factor Receptor (mEGF-R)." D.W. Cai, R. Somasundaram, S. Pereira, W. Wunner, S. Eck, E. Furth, K. Judy, S. Earp and D. Herlyn. The Wistar Institute and University of...

Retroviral Gene Transfer of Protectin (CD59) Enhances the Resistance of Human Melanoma Cells to Homologous Complement-Mediated Lysis.
June 8, 1998... "Retroviral Gene Transfer of Protectin (CD59) Enhances the Resistance of Human Melanoma Cells to Homologous Complement-Mediated Lysis." S. Coral, E. Fonsatti, L. Sigalotti, F. Colizzi, A. Gasparollo, I. Cattarossi, A. Visintin, M.P. Colombo, M....

Immunization of Mice with the Synthetic Nonasaccharide KH-1 Results in Antibodies Against Adenocarcinoma Cells.
June 8, 1998... "Immunization of Mice with the Synthetic Nonasaccharide KH-1 Results in Antibodies Against Adenocarcinoma Cells." G. Ragupathi, P.P. Deshpande, L. Howard, K.O. Lloyd, S.J. Danishefsky and P.O. Livingston. Memorial Sloan-Kettering Cancer Center,...

Accelerated Repair of Acetic Acid Induced Gastric Ulcers Using Antiviral and Antibacterial Vaccines Stimulating Angiogenesis and Fibrogenesis in Rats.
June 8, 1998... "Accelerated Repair of Acetic Acid Induced Gastric Ulcers Using Antiviral and Antibacterial Vaccines Stimulating Angiogenesis and Fibrogenesis in Rats." O.A. Bedini, O.M. Laudanno, A. Naves, G. Guastalli, P. San Miguel and J.A. Cesolari. Cat. de...

The Clinical Role of Specific IgE and IgG4 Antibodies in Patients Having Immunotherapy for Seasonal Allergic Rhinitis.
June 8, 1998... Ohashi, Y.; Nakai, Y.; Tanaka, A.; Kakinoki, Y.; Masamoto, T.; Kato, A.; Sakamoto, H. "The Clinical Role of Specific IgE and IgG4 Antibodies in Patients Having Immunotherapy for Seasonal Allergic Rhinitis." Clinical Otolaryngology, April...

Dystrophin Acts as a Transplantation Rejection Antigen in Dystrophin-Deficient Mice: Implication for Gene Therapy.
June 8, 1998... Ohtsuka, Y.; Udaka, K.; Yamashiro, Y.; Yagita, H.; Okumura, K. "Dystrophin Acts as a Transplantation Rejection Antigen in Dystrophin-Deficient Mice: Implication for Gene Therapy." Journal of Immunology, May 1, 1998;160(9):4635-4640. According...

Randomised Controlled Trial of Aminosidine (Paromomycin) Upsilon Sodium Stibogluconate for Treating Visceral Leishmaniasis in North Bihar, India.
June 8, 1998... Jha, T.K.; Olliaro, P.; Thakur, C.P.N.; Kanyok, T.P.; Singhania, B.L.; Singh, I.J.; Singh, N.K.P.; Akhoury, S.; Jha, S. "Randomised Controlled Trial of Aminosidine (Paromomycin) Upsilon Sodium Stibogluconate for Treating Visceral Leishmaniasis in...

Cationic Lipids Enhance Cytokine and Cell Influx Levels in the Lung Following Administration of Plasmid: Cationic Lipid Complexes.
June 8, 1998... Freimark, B.D.; Blezinger, H.P.; Florack, V.J.; Nordstrom, J.L.; Long, S.D.; Deshpande, D.S.; Nochumson, S.; Petrak, K.L. "Cationic Lipids Enhance Cytokine and Cell Influx Levels in the Lung Following Administration of Plasmid: Cationic Lipid...

Adjuvant Therapy of Melanoma.
June 8, 1998... "Adjuvant Therapy of Melanoma." Seminars in Surgical Oncology, June 1998;14(4):302-310. According to the authors' abstract of an article published in Seminars in Surgical Oncology, "Patients with AJCC Stage IIB and III melanoma have a poor...

Overview of Melanoma Vaccines: Active Specific Immunotherapy for Melanoma Patients.
June 8, 1998... "Overview of Melanoma Vaccines: Active Specific Immunotherapy for Melanoma Patients." Seminars in Surgical Oncology, June 1998;14(4):328-336. According to the authors' abstract of an article published in Seminars in Surgical Oncology,...

Neutralizing Mechanism of a Monoclonal Antibody Against Japanese Encephalitis Virus Glycoprotein E.
June 8, 1998... "Neutralizing Mechanism of a Monoclonal Antibody Against Japanese Encephalitis Virus Glycoprotein E." American Journal of Tropical Medicine and Hygiene, April 1998;58(4):389-398. According to the authors' abstract of an article published in...

Report of Immune Monitoring of Prostate Cancer Patients Undergoing T-Cell Therapy Using Dendritic Cells Pulsed With HLA-A2-Specific Peptides From Prostate-Specific Membrane Antigen (PSMA).
June 8, 1998... Salgaller, M.L.; Lodge, P.A.; Mclean, J.G.; Tjoa, B.A.; Loftus, D.J.; Ragde, H.; Kenny, G.M.; Rogers, M.; Boynton, A.L.; Murphy, G.P. "Report of Immune Monitoring of Prostate Cancer Patients Undergoing T-Cell Therapy Using Dendritic Cells Pulsed...

Interferon gamma-1b Compared With Placebo in Metastatic Renal-Cell Carcinoma.
June 8, 1998... Gleave, M.E.; Elhilali, M.; Fradet, Y.; Davis, I.; Venner, P.; Saad, F.; Klotz, L.H.; Moore, M.J.; Paton, V.; Bajamonde, A. "Interferon gamma-1b Compared With Placebo in Metastatic Renal-Cell Carcinoma." New England Journal of Medicine, April 30,...

Recombinant Human Interleukin-2, Recombinant Human Interferon alfa-2a, or Both in Metastatic Renal-Cell Carcinoma.
June 8, 1998... Negrier, S.; Escudier, B.; Lasset, C.; Douillard, J.Y.; Savary, J.; Chevreau, C.; Ravaud, A.; Mercatello, A.; Peny, J.; Mousseau, M.; Philip, T.; Tursz, T. "Recombinant Human Interleukin-2, Recombinant Human Interferon alfa-2a, or Both in...

T-Cell Vaccination Induces T-Cell Receptor V beta-Specific Qa-1-Restricted Regulatory CD8(+) T Cells.
June 8, 1998... Jiang, H.; Kashleva, H.; Xu, L.X.; Forman, J.; Flaherty, L.; Pernis, B.; Braunstein, N.S.; Chess, L. "T-Cell Vaccination Induces T-Cell Receptor V beta-Specific Qa-1-Restricted Regulatory CD8(+) T Cells." Proceedings of the National Academy of...

Current Trends in Chemotherapy for Metastatic Nonseminomatous Testicular Germ Cell Tumors.
June 8, 1998... Bokemeyer, C. "Current Trends in Chemotherapy for Metastatic Nonseminomatous Testicular Germ Cell Tumors." Oncology, May-June 1998;55(3):177-188. According to the author's abstract of an article published in Oncology, "With the introduction of...

Detection of Kanamycin-Resistant Mycobacterium tuberculosis by Identifying Mutations in the 16S rRNA Gene.
June 8, 1998... Suzuki, Y.; Katsukawa, C.; Tamaru, A.; Abe, C.; Makino, M.; Mizuguchi, Y.; Taniguchi, H. "Detection of Kanamycin-Resistant Mycobacterium tuberculosis by Identifying Mutations in the 16S rRNA Gene." Journal of Clinical Microbiology, May...

Depletion of anti-Gal alpha 1-3Gal Antibody in Baboons by Specific alpha-Gal Immunoaffinity Columns.
June 8, 1998... Kozlowski, T.; Ierino, F.L.; Lambrigts, D.; Foley, A.; Andrews, D.; Awwad, M.; Monroy, R.; Cosimi, A.B.; Cooper, D.K.C.; Sachs, D.H. "Depletion of anti-Gal alpha 1-3Gal Antibody in Baboons by Specific alpha-Gal Immunoaffinity Columns."...

The Role of Antibodies in Acute Vascular Rejection of Pig-to-Baboon Cardiac Transplants.
June 8, 1998... Lin, S.S.; Weidner, B.C.; Byrne, G.W.; Diamond, L.E.; Lawson, J.H.; Hoopes, C.W.; Daniels, L.J.; Daggett, C.W.; Parker, W.; Harland, R.C.; Davis, R.D.; Bollinger, R.R.; Logan, J.S.; Platt, J.L. "The Role of Antibodies in Acute Vascular Rejection...

Polyvalent Melanoma Cell Vaccine Induces Humoral and Cell-Mediated Responses.
June 22, 1998... Correlation of immune responses during vaccination with a polyvalent melanoma cell vaccine (PMCV) determined increases in overall survival in melanoma patients. Researchers from the John Wayne Cancer Institute, California, conducted a phase II...

Fucosyl-GM1 Ganglioside Vaccine Is Immunogenic in SCLC Patients.
June 22, 1998... Vaccination with a fucosyl-GM1 (Fuc-GM1) ganglioside vaccine produced immunogenic responses in a cohort of patients with small cell lung cancer (SCLC). Maura N. Dickler, representing colleagues from the Memorial Sloan-Kettering Cancer Center,...

Immunotoxin Therapy Prolongs Survival in AML Model.
June 22, 1998... A novel fusion toxin (DT[388]-GM-CSF) significantly prolonged the survival of mice in a SCID mouse model of human acute myeloid leukemia (AML). Philip Hall, representing colleagues from the Medical University of South Carolina, presented...

PROSTVAC Progresses to Phase II Trials In Battle against Prostate Cancer.
June 22, 1998... A vaccine protocol based on a recombinant vaccinia virus expressing prostate specific antigen (PSA) (PROSTVAC) was administered safely to patients with adenocarcinoma of the prostate. Joseph P. Eder Jr., representing colleagues from the...

Ho's "Raging Fire" Put Out.
June 22, 1998... A new theory of AIDS pathogenesis supersedes the "raging fire" and "tap-and-drain" models put forward by David Ho. Instead of a constant systemic battle between a horde of HIV virions and a constantly surging supply of new T cells, the new...

Chemokine Has Key Role in Virus-Induced Eye Inflammation.
June 22, 1998... The CC chemokine macrophage inflammatory protein-1(alpha) (MIP-1(alpha)) is necessary for the development of severe stromal keratitis. MIP-1(alpha) is not required to control virus growth in the cornea, however, indicated Terrence M. Tumpey,...

New Tests Demonstrate Much Larger, More Specific Immune Responses to Viruses.
June 22, 1998... Using novel assays described as the new "gold standard" for measuring specific immune responses to viruses, researchers have found that the response of CD8(+) T cells, which provide the front line of protection against invading viruses, is...

HIV Infected Adults Show Evidence of Thymus Activity.
June 22, 1998... Contrary to the widely held belief that the thymus, an organ essential for producing competent immune cells, is not functional in adulthood, researchers at the Gladstone Institute of Virology and Immunology, University of California at San...

Interferon Has Some Activity in Children with HCV Infection.
June 22, 1998... Interferon alpha offers some efficacy in the treatment of chronic hepatitis C virus infection in children, according to a report from Massachusetts. Researcher Maureen M. Jonas and colleagues from Boston's Children's Hospital found, however,...

TNF Peptides Represents Potential Tuberculosis Treatment.
June 22, 1998... The 11 mer peptide based on amino acids 70 to 80 of the human tumor necrosis factor may be an effective treatment for mycobacterial infections. Researcher W.J. Britton and colleagues from Australia's Centenary Institute of Cancer Medicine and...

Impact of Innate Immune Response on Strategies for In Vivo Application of Adenoviral Vectors.
June 22, 1998... "Impact of Innate Immune Response on Strategies for In Vivo Application of Adenoviral Vectors." G. Wolf, S. Worgall, R.G. Crystal, H. Lorenz, G. Willimsky, B. Dorken and T. Blankenstein. Humboldt-University of Berlin, Germany; Max-Delbruck-Center...

Mono- and Bicistronic Infectious Adenovirus Cosmids for the Genetic Modification of Dendritic Cells.
June 22, 1998... Mono- and Bicistronic Infectious Adenovirus Cosmids for the Genetic Modification of Dendritic Cells." W. Lindenmaier, K.E.D. Ditimar, C. Hiller-Hotinka, I. Dallmann, K. Littman-JanBen, R. Bonewald, M. Templin, S. Weib and J. Atzpodien. Dept. of...

Establishment of Genetically Modified Cancer Cells for Experimental Cancer Therapy.
June 22, 1998... "Establishment of Genetically Modified Cancer Cells for Experimental Cancer Therapy." Y.-C. Che, C.-H. Lo and R.-L. Yen. Department of Radiation Oncology, Chang-Gung Memorial Hospital, Kwei-Shan, Tao-Yuan, Taiwan. According to an abstract...

Antitumor Effect of Fibroblast Engineered to Express Fas Ligand, (FasL) on Hepatocellular Carcinoma (HCC).
June 22, 1998... "Antitumor Effect of Fibroblast Engineered to Express Fas Ligand, (FasL) on Hepatocellular Carcinoma (HCC)." M. Drozdzik, C. Qian, J.J. Lasarte and J. Prieto. Department of Medicine, School of Medicine, University of Navarra, Pamplona, Spain....

Immunologic Memory Induced by a Glycoconjugate Vaccine in a Murine Adoptive Lymphocyte Transfer Model.
June 22, 1998... Guttormsen, H.K.; Wetzler, L.M.; Finberg, R.W.; Kasper, D.L. "Immunologic Memory Induced by a Glycoconjugate Vaccine in a Murine Adoptive Lymphocyte Transfer Model." Infection and Immunity, May 1998;66(5):2026-2032. According to the authors'...

Clinical Intestinal Transplantation: New Perspectives and Immunologic Considerations.
June 22, 1998... Abuelmagd, K.; Reyes, J.; Todo, S.; Rao, A.; Lee, R.; Irish, W.; Furukawa, H.; Bueno, J.; Mcmichael, J.; Fawzy, A.T.; Murase, N.; Demetris, J.; Rakela, J.; Fung, J.J.; Starzl, T.E. "Clinical Intestinal Transplantation: New Perspectives and...

Prospective Randomized Trial of Two Dose Levels of Interferon alfa With Zidovudine for the Treatment of Kaposi's Sarcoma Associated With Human Immunodeficiency Virus Infection: A Canadian HIV Clinical Trials Network Study.
June 22, 1998... Shepherd, F.A.; Beaulieu, R.; Gelmon, K.; Thuot, C.A.; Sawka, C.; Read, S.; Singer, J. "Prospective Randomized Trial of Two Dose Levels of Interferon alfa With Zidovudine for the Treatment of Kaposi's Sarcoma Associated With Human...

Involvement of T Cells in Enhanced Resistance to Klebsiella pneumoniae Septicemia in Mice Treated With Liposome-Encapsulated Muramyl Tripeptide Phosphatidylethanolamine or gamma Interferon.
June 22, 1998... Tenhagen, T.L.M.; Vanvianen, W.; Savelkoul, H.F.J.; Heremans, H.; Buurman, W.A.; Bakkerwoudenberg, I.A.J.M. "Involvement of T Cells in Enhanced Resistance to Klebsiella pneumoniae Septicemia in Mice Treated With Liposome-Encapsulated Muramyl...

Active and Passive Immunity Against Borrelia burgdorferi Decorin Binding Protein A (DbpA) Protects Against Infection.
June 22, 1998... Hanson, M.S.; Cassatt, D.R.; Guo, B.P.; Patel, N.K.; Mccarthy, M.P.; Dorward, D.W.; Hook, M. "Active and Passive Immunity Against Borrelia burgdorferi Decorin Binding Protein A (DbpA) Protects Against Infection." Infection and Immunity, May...

No Evidence for Increased Frequency of Autoantibodies During Interferon-beta(1b) Treatment of Multiple Sclerosis.
June 22, 1998... "No Evidence for Increased Frequency of Autoantibodies During Interferon-beta(1b) Treatment of Multiple Sclerosis." Acta Neurologica Scandinavica, May 1998;97(5):320-323. According to the authors' abstract of an article published in Acta...

IL-2 Immunotherapy Maintains Disease Response in HIV Associated Malignancies.
June 29, 1998... A phase II study demonstrated that interleukin-2 (IL-2) can be safely tolerated in HIV patients and help maintain disease response against lymphoma. Z.P. Bernstein, representing colleagues from the Roswell Park Cancer Institute, New York,...

New Method Now Monitors Blood Dendritic Cell Numbers.
June 29, 1998... A new method has been devised to monitor patient blood dendritic cell (DC) numbers. D.N.J. Hart, representing colleagues from the Christchurch Hospital, Christchurch, New Zealand, explained the process at the 34th Annual Meeting of the...

Reduced Lymphocyte Counts Persist after Stem Cell Apheresis.
June 29, 1998... Donors who underwent peripheral blood stem cell (PBSC) apheresis had significantly reduced lymphocyte counts that persisted up to 555 days. "Although no clinically adverse effects have yet been observed in our donor group, a potential...

AML Patients with High Risk of Relapse May Benefit from Immunotherapy.
June 29, 1998... Slow lymphocyte recovery after allogeneic bone marrow transplantation may be associated with a higher risk of relapse in patients with acute myeloid leukemia. Such patients may benefit from immune manipulations after bone marrow...

IL-12 Treatment Helps Prevent Acute GVHD.
June 29, 1998... Interleukin-12 treatment at the time of bone marrow transplantation may disturb the activation of alloreactive donor CD4(+) T cells that play a key role in the pathogenesis of acute graft-versus-host disease (GVHD). "We hypothesize that these...

Effectiveness Studies Seen As Vaccine-Marketing Tool.
June 29, 1998... Efficacy trials of candidate vaccines don't provide enough real-world information. As a result, argues U.S. National Institutes of Health researcher John Clemens, manufacturers with a successful vaccine often find themselves unable to market...

Elevated EBV DNA after Stem Cell Transplant May Be Associated with EBV-LPD.
June 29, 1998... The early detection of Epstein-Barr virus-induced lymphoproliferative disease (EBV-LPD) in high risk patients after stem cell transplantation (SCT) is important for improving outcomes. Indiana University Medical Center researcher Kenneth G....

Dendritic Cells Have Immunotherapeutic Potential in Myeloma Treatment.
June 29, 1998... Dendritic cells generated from mononuclear cells and CD34 cells of myeloma patients do not harbor human herpesvirus 8. These cells are an appropriate vehicle for studying immunotherapy treatment of myeloma, indicated G.M. Cull and colleagues,...

Mouse May be Key to Understanding Mycobacterial Infection.
June 29, 1998... An interferon-gamma-deficient mouse model may help explain mycobacterial infection as well as the mechanisms that control other chronic infections. Tests with the model, developed by researchers at the Massachusetts Institute of Technology,...

Gene Gun Immunization using Plasmid DNA Expressing IFN-(alpha) or IL-12 in Combination with Plasmid DNA Expressing a Model Antigen Mimics Immunization with a Recombinant Adenoviral Vector.
June 29, 1998... "Gene Gun Immunization using Plasmid DNA Expressing IFN-(alpha) or IL-12 in Combination with Plasmid DNA Expressing a Model Antigen Mimics Immunization with a Recombinant Adenoviral Vector." T. Tuting, A. Gamboffo, W.J. Storkus, A.B. DeLeo....

Clinical and Immune Responses in Surgically Resected Colorectal Cancer (CRC) Patients Treated with an Anti-Idiotype (Id) Monoclonal Antibody that Mimics Carcinoembryonic Antigen (CEA) With or Without 5-Fluorouracil (5-FU).
June 29, 1998... "Clinical and Immune Responses in Surgically Resected Colorectal Cancer (CRC) Patients Treated with an Anti-Idiotype (Id) Monoclonal Antibody that Mimics Carcinoembryonic Antigen (CEA) With or Without 5-Fluorouracil (5-FU)." K.A. Foon, W.J. John,...

Phase II Trial of the Bispecific Antibody MDX-H210 (ANTI-HER2/NeuxAnti-CD64) Combined with GM-CSF in Patients with Advanced Prostate and Renal Cell Carcinomas that Express HER2/Neu.
June 29, 1998... "Phase II Trial of the Bispecific Antibody MDX-H210 (ANTI-HER2/NeuxAnti-CD64) Combined with GM-CSF in Patients with Advanced Prostate and Renal Cell Carcinomas that Express HER2/Neu." N. James, P. Atherton, A. Koletsky, N. Tchekmedyian and R....

Immunotherapy of Hormone Refractory Prostate Cancer with Antigen-Pulsed Dendritic Cells: A Phase I/II Trial.
June 29, 1998... "Immunotherapy of Hormone Refractory Prostate Cancer with Antigen-Pulsed Dendritic Cells: A Phase I/II Trial." F.H. Valone, E.J. Small, S. Whisenant, M. Peshwa, G. Strang, R. Laus, C. Ruegg and W. van Schooten. Dendreon Corporation, Mountain...

DNA as Vaccine or Therapeutic Against Cancer and Viral Infections.
June 29, 1998... "DNA as Vaccine or Therapeutic Against Cancer and Viral Infections." K. Moelling, J. Paviovic, J. Schultz, M. Nawrath and D. Petrzilka. Institute of Medical Virology of the University of Zurich, Gloriastrasse, Zurich, Switzerland. According to...

Effect of L-carnitine on Human Immunodeficiency Virus-1 Infection-Associated Apoptosis: A Pilot Study.
June 29, 1998... Moretti, S.; Alesse, E.; Dimarzio, L.; Zazzeroni, F.; Ruggeri, B.; Marcellini, S.; Famularo, G.; Steinberg, S.M.; Boschini, A.; Cifone, M.G.; Desimone, C. "Effect of L-carnitine on Human Immunodeficiency Virus-1 Infection-Associated Apoptosis: A...

Bacillus Calmette-Guerin (BCG) Immunotherapy for Bladder Cancer: Review of Complications and Their Treatment.
June 29, 1998... "Bacillus Calmette-Guerin (BCG) Immunotherapy for Bladder Cancer: Review of Complications and Their Treatment." Australian and New Zealand Journal of Surgery, May 1998;68(5):340-344. According to the authors' abstract of an article published in...

Long-Term Immune Reconstitution and Outcome After HLA-Nonidentical T-Cell-Depleted Bone Marrow Transplantation for Severe Combined Immunodeficiency: A European Retrospective Study of 116 Patients.
June 29, 1998... Haddad, E.; Landais, P.; Friedrich, W.; Gerritsen, B.; Cavazzanacalvo, M.; Morgan, G.; Bertrand, Y.; Fasth, A.; Porta, F.; Cant, A.; Espanol, T.; Muller, S.; Veys, P.; Vossen, J.; Fischer, A. "Long-Term Immune Reconstitution and Outcome After...

Class II-Transfected Tumor Cells Directly Present Endogenous Antigen to CD4(+) T Cells in vitro and Are APCs for Tumor-Encoded Antigens in vivo.
June 29, 1998... Armstrong, T.D.; Clements, V.K.; Ostrandrosenberg, S. "Class II-Transfected Tumor Cells Directly Present Endogenous Antigen to CD4(+) T Cells in vitro and Are APCs for Tumor-Encoded Antigens in vivo." Journal of Immunotherapy, May...

DNA Immunization With Minigenes: Low Frequency of Memory Cytotoxic T Lymphocytes and Inefficient Antiviral Protection Are Rectified by Ubiquitination.
June 29, 1998... Rodriguez, F.; An, L.L.; Harkins, S.; Zhang, J.; Yokoyama, M.; Widera, G.; Fuller, J.T.; Kincaid, C.; Campbell, I.L.; Whitton, J.L. "DNA Immunization With Minigenes: Low Frequency of Memory Cytotoxic T Lymphocytes and Inefficient Antiviral...

Induction of Systemic and Mucosal Immune Responses to Human Immunodeficiency Virus Type 1 by a DNA Vaccine Formulated With QS-21 Saponin Adjuvant Via Intramuscular and Intranasal Routes.
June 29, 1998... Sasaki, S.; Sumino, K.; Hamajima, K.; Fukushima, J.; Ishii, N.; Kawamoto, S.; Mohri, H.; Kensil, C.R.; Okuda, K. "Induction of Systemic and Mucosal Immune Responses to Human Immunodeficiency Virus Type 1 by a DNA Vaccine Formulated With QS-21...

Bactericidal Monoclonal Antibodies That Define Unique Meningococcal B Polysaccharide Epitopes That Do Not Cross-React With Human Polysialic Acid.
June 29, 1998... Granoff, D.M.; Bartoloni, A.; Ricci, S.; Gallo, E.; Rosa, D.; Ravenscroft, N.; Guarnieri, V.; Seid, R.C.; Shan, A.; Usinger, W.R.; Tan, S.Q.; Mchugh, Y.E.; Moe, G.R. "Bactericidal Monoclonal Antibodies That Define Unique Meningococcal B...

Cationic Liposomes Enhance the Rate of Transduction by a Recombinant Retroviral Vector in vitro and in vivo.
June 29, 1998... Porter, C.D.; Lukacs, K.V.; Box, G.; Takeuchi, Y.; Collins, M.K.L. "Cationic Liposomes Enhance the Rate of Transduction by a Recombinant Retroviral Vector in vitro and in vivo." Journal of Virology, June 1998;72(6):4832-4840. According to the...