Immunotherapy Weekly articles from July 2003

Immunotherapy Weekly archives from July 2003

Growth factor regulation may block tumor entry by immune effector cells.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Growth factor regulation may block tumor entry by immune effector cells. "The expression of endothelial cell (EC) adhesion molecules involved in leukocyte-vessel wall interactions is suppressed in...

The elderly have an increased susceptibility to infection following trauma.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Geriatric subjects have decreased neutrophil superoxide function; which combined with trauma, leads to a decrease in immune response and an increase in bacterial and fungal infections. "Previous...

More cytokines are produced by circulating lymphoid and myeloid cells in AML.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Acute myelogenous leukemia patients have blood cells that produce more cytokines than normal cells. According to recent research from England, "A simple assay was developed to assess the potential...

The risk for childhood acute lymphoblastic leukemia is diminished with allergy.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Atopic disease such as hay fever, neurodermatitis, and contact eczema appears to protect against acute lymphoblastic leukemia risk. "Our objective was to test the hypothesis that the risk of...

Antifungal drug helps kids with immune disorder avoid hospitalization.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- The antifungal medication itraconazole is well tolerated and effectively prevents fungal infections in children who have chronic granulomatous disease (CGD), report scientists from the U.S. National...

Immune system stages of eliminating viral infections, cancer cells discovered.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Researchers at the University of Texas Southwestern Medical Center at Dallas have partially uncovered the stages in the elimination of viral infections and cancer cells by the human immune system. ...

Strain differences affect electroporation-mediated transgene expression in mice.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Strain differences affect electroporation-mediated transgene expression in mice. "We previously demonstrated that cytokine expression following intramuscular gene transfer of a naked plasmid is...

Sporadic lower motor neuron disease can be clinically sub-classified.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- New classifications of lower motor neuron disease are proposed following differential clinical analysis. According to recent research from Netherlands, "The discovery of the genetic basis of...

WHO criteria for trypanosomiasis can be improved by measuring IgM in the CSF.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Researchers propose a change to the WHO stage determination for African trypanosomiasis to new CNS involvement criteria that include IgM and exclude determination of trypanosomes. According to...

Low concentration, concerted action of mixed cytokines have more potent effects.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Airway fibroblasts respond differently to sets of cytokines produced by allergen stimulated and nonstimulated peripheral blood mononuclear cells. "Accumulating data show that fibroblasts are...

Fc epsilon receptor for IgE beta chain is a catalyst for IgE reactions.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- The beta chain of the IgE receptor acts as a catalyst for signal transduction and amplification. According to published research from Japan, "The beta chain, a component of the high-affinity...

Study shows levocetirizine improves allergic rhinitis sufferers' QOL.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Study data indicate Xyzal (levocetirizine; UCB Pharma) significantly improves patients' quality of life as compared with placebo in patients with persistent allergic rhinitis (PER). The new quality...

White wine contains proteins from grapes and yeast; none from bacteria.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Chardonnay wine contains more proteins from grapes, some from yeast, and none from bacteria. "The objective of this study was to analyze the origin of proteins of a Chardonnay wine. Three various...

An amebic thiol-specific antioxidant prevents killing by host mononuclear ROS.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Amebic dysentery begins with attachment to host mononuclear cells with GalNAc lectin and attachment of a thiol specific antioxidant to its cytoplasmic domain to neutralize reactive oxygen species...

AAAAI offers advice on avoiding stinging insect allergies.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Summer is a time of year when many people are stung by insects. Up to 5% of Americans are at risk for severe, potentially life-threatening allergic reactions from stinging insects, according to the...

Serratia species have multiple mechanisms, including unique beta-lactamases.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Potential pathogen strains of Serratia are found to be naturally resistant to many antibiotics and to produce some unique beta-lactamases. According to recent research published in the Journal of...

EGF-positive cancer may be treatable with diptheria toxin-EGF fusion protein.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Epidermal growth factor positive glioblastomas may be treatable with a targeted diptheria toxin-EGF fusion protein. "The cytotoxicity of a diphtheria toxin-human epidermal growth factor fusion...

Asthma in high percentage of North Carolina children undiagnosed, study shows.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- A new, first-of-its kind, University of North Carolina at Chapel Hill survey of 122,829 children at 499 middle schools in the state has turned up disturbing information about asthma, now the most common...

Study shows link between food allergies and life-threatening asthma attacks.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- For the first time, researchers have shown a link between food allergies and life-threatening asthma attacks in children, highlighting the important relationship between allergy and severe asthma in...

Indoleamine 2,3-dioxygenase gene is highly induced by IgE receptor and IFN-gamma.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Indoleamine 2,3-dioxygenase gene is highly induced by IgE receptor, Fc epsilon RI, and IFN-gamma in atopic monocytes. "Antigen-presenting cells (APCs) are crucial in regulating the outcome of T...

Patients testing positive for anti-Hu antibodies may have underlying cancer.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- When patients with autoimmune diseases test positive for anti-Hu antibodies, there may be an underlying cancer. According to published research from France, "Sera from 71 patients with primary...

T cell sensitization with Bis VIII may cause immune incompetence.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Autoimmune disease could be treated with Bis VIII so that T cell suicide by apoptosis could occur properly, but there would be a risk of inability to respond properly to infection. "Death...

Patients with autoimmune hepatitis form CK19-specific T cells.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Patients with autoimmune hepatitis form CK19-specific T cells "Recently we have demonstrated the existence of anti-cytokeratin 19 (CK19) antibodies in sera of patients with autoimmune hepatitis...

Yersinia enterocolitica infection does not appear to lead to thyroid disease.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Serum antibodies to an indicator of autoimmune thyroid disease and to Yersinia enterocolitica are higher in relatives of patients with thyroid disease, but they do not relate to each other in any way....

Leukocyte depletion prior to storage sometimes will not filter well.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Not all blood behaves the same in attempts to store autologous blood depleted of leukocytes; sickle cell anemia is an identifiable reason in some cases. According to a study from Germany, "New...

Hijacking Rho GTPases allows control of life or death of infected cells.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Some pathogenic bacteria hijack the infected cell's cytoskeleton and Rho GTPases so that they can control life or death issues in the cells they inhabit. According to recent research from Italy,...

Plasmapheresis was used to sucessfully lower the titers of autoantibodies.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Plasmapheresis was used to lower the titers of autoantibodies to treat bullous pemphigoid. Recent research published in the Journal of Dermatology "reports a case of bullous pemphigoid successfully...

IFN-alpha enhances CD154 expression, but needs IL-12 to upregulate IFN-gamma.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Interferon alpha alone is capable of increasing CD154 and appears to need IL-12 to enhance IFN-gamma expression in CD4+ T cells. According to published research from Japan, "Like IL-12, IFN-alpha...

Aspirin-exacerbated respiratory disease patients can take new COX-2 versions.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Aspirin-exacerbated respiratory disease patients can consider taking the new, highly selective COX-2 inhibitors. "Aspirin and nonsteroidal antiinflammatory drugs (NSAIDs) exert their clinical...

GenOdyssee presents preclinical results of interferon alpha variants.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- GenOdyssee, S.A., presented preclinical data on its natural functional variants of interferon alpha (IFN alpha) in a poster presentation at the American Society of Clinical Oncology (ASCO) meeting in...

Leukemia cells internalize specific antibodies that could be linked to toxin.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Chronic lymphocytic leukemia B cells internalize specific antibodies: anti-CD5, CD22, and CD40. According to published research from Germany, "B-cell chronic lymphocytic leukemia (B-CLL) cannot be...

Apoptosis plus CD80 costimulation promote immune response by melanoma cells.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Apoptotic cell death in conjunction with CD80 costimulation conferred uveal melanoma cells with the ability to induce immune responses. "Uveal melanoma is a rare malignancy with a poor prognosis...

Chronically infected individuals have an imbalance of cytokines to antioxidants.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Chronic Chagas disease sufferers have an imbalance of cytokines to antioxidants, a fact that may lead to alternate therapeutic approaches to disease. According to published research from France,...

RDP58 allows higher dosing of chemotherapy without increased GI toxicities.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- SangStat (SANG) announced that, in a mouse tumor model, treatment with RDP58, its anti-inflammatory drug candidate, allowed a significant increase in the dose of irinotecan without increasing...

ImClone Systems and Bristol-Myers discuss Erbitux with FDA.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- ImClone Systems, Inc., (IMCLE) and Bristol-Myers Squibb Co. (BMY) have met with the U.S. Food and Drug Administration (FDA) to discuss clinical trial data including the Merck, KgaA, sponsored 007 phase...

Aspirin-exacerbated respiratory disease desensitization is complex.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Aspirin exacerbated respiratory disease symptoms are caused by histamine and Us, but loss of symptoms in desensitization may involve lowered histamine, and continued LT synthesis but fewer cysLT...

Interleukin-6 promoter polymorphism associated with type 2 diabetes.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- An association between the interleukin-6 (-174) G/C promoter polymorphism and type 2 diabetes has been found in Native Americans and Caucasians. "Chronic low-grade activation of the immune system...

Advances in xenotransplantation reported.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- BioTransplant, Inc., (BTRNQ.OB) announced that scientists from Immerge BioTherapeutics, the company's joint venture with Novartis Pharma AG, have recently reported results from two studies highlighting...

Capillary electrophoresis immunoassay is comparable to chemiluminescence.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Capillary electrophoresis immunoassay is comparable to chemiluminescent assay for estradiol serology. According to a study from People's Republic of China, "A rapid and sensitive capillary...

Therapeutic antibodies for targeted treatment of cancer are the next generation.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Biotechnology is continuing to allow improvements in targeted antibody therapy on many fronts. According to published research from England, "The last 5 years have seen a major upturn in the...

Corporate update provided for U.K.-based biotech.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Peter Garland, Cambridge Antibody Technology's chairman, released the following statement: The core value of the company is in the pipeline of products derived from our exceptional technology. The...

Fujisawa, GlaxoSmithKline to copromote Protopic.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Fujisawa Healthcare, Inc., and GlaxoSmithKline (GSK) Consumer Healthcare announced a co-promotion agreement for Protopic (tacrolimus ointment) in the United States. Protopic, currently marketed by...

Peritoneal fluid has lower amounts of some proteins and increased IL-10.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Endometriosis involves peritoneal fluid with lower amounts of some proteins and increased IL-10 production. "A growing body of evidence suggests that endometriosis modulates the microenvironment of...

L10 ribosomal protein has structural homology with QM, reduces cell growth.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Entamoeba histolytica has a ribosomal protein, L10, which has homology with human QM and is involved in reducing cell growth. According to a study from Mexico, "The complete amino acid sequence of...

Blood test provides solution to rising obesity costs.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- American Medical Testing Laboratories (AMTL Corp.) of Hollywood, Florida, claims it can reduce the $93 billion obesity cost by telling people what foods they are allergic to as determined by their...

Cutaneous infections create challenges, but there are some available treatments.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Cutaneous fungal infections still create challenges, but there are some available treatments. According to recent research published in the journal Infectious Disease Clinics of North America,...

Immunomodulation can also be used to combat invasive fungus.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Antifungals are not the only way to combat fungal infection; immunomodulation can be used. According to a study from Greece, "Genetic and acquired determinants increase the risk for invasive fungal...

Carditis may be associated directly or indirectly to Helicobacter pylori.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Carditis is a risk factor associated with several aspects of gastritis and may be due to Helicobacter pylori. "Dyspepsia is a common clinical problem. Its causes include peptic ulcer disease,...

Enolase may contribute to Aeromonas hydrophila pathogenicity in enteritis.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Aeromonas hydrophila expresses enolase, which binds human plasminogen; this may contribute to pathogenicity. According to a study from the United States, "Aeromonas hydrophila is an emerging human...

Griscelli syndrome without hemophagocytosis occurs with a new Rab27A mutation.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- A new deletion in Rab27A gene produces a phenotype of Griscelli syndrome without hemophagocytosis but with apparent partial albinism and Elejalde immunodeficiency syndrome characteristics. ...

Human lymphocyte proteasome structure and activity changes with age.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Human lymphocyte proteasome structure and activity changes with age. "Key actors of the immune response, lymphocytes exhibit functional deficits with advancing age. For instance, the age-related...

Many immune-mediated neuropathies are tied to immunosenescence events.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- It is becoming more apparent that many immune-mediated neuropathies are tied to immunosenescence events. According to a study from Switzerland, "Immune-mediated peripheral neuropathies are more...

CD91 upregulated on monocytes from long-term nonprogressors.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- CD91 is upregulated on monocytes for long-term nonprogressing HIV patients. "A small proportion of patients with human immunodeficiency virus type 1 (HIV-1) remains asymptomatic for a long period...

Dendritic cells may aid pathogenesis through T-cell recruitment.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Dendritic cells may aid HIV pathogenesis through T-cell recruitment. "Monocyte-derived dendritic cells (MDDCs) can efficiently bind and transfer HIV infectivity without themselves becoming...

Gastric and enterohepatic species have different lectin adhesins.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Helicobacter species have different lectin adhesins for attachment that may vary dependent on where it likes to live. According to recent research from Sweden, "Helicobacter pylori is able to...

Dual cancers can coexist: Chronic lymphocytic leukemia and mantle cell lymphoma.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- A patient had dual cancers: chronic lymphocytic leukemia in blood and mantle cell lymphoma in lymph nodes. According to recent research from Portugal, "We report a case of a patient with 2 B-cell...

Adrenomedullin in brain affects autonomic centers, regulating homeostasis.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Adrenomedullin is found to affect brain autonomic centers as a signalling molecule, to regulate homeostatic balance. "In addition to its role as a potent vasodilator, adrenomedullin (ADM) affects...

Gonadotropin treatment of PBMC restores cytokine production to normal.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Idiopathic hypogonadotropic hypogonadism creates abnormal cytokine profiles, and gonadotropin treatment of PBMC returns the effect to normal. "In the present study, we aimed to investigate the...

CD8+ proliferation program may involve antigen and external interactions.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- A mathematical model for the program that may be used for CD8+ response to antigen reveals that antigen exposure and external interactions are probably involved. "Recent experimental results show...

Bacterial sensor gets the nod.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- The NOD family of proteins acts as an alarm for trespassing bacteria that hide inside our cells, but what NODs detect has been unclear. In the July 2003 issue of Nature Immunology, scientists show...

The oriental herbal preparation allergina appears to inhibit TNF-alpha.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Macrophage related or induced inflammatory diseases may be treatable by oriental allergina, which appears to inhibit TNF-alpha. "The oriental herbal combination allergina has been shown to inhibit...

Tissue factor messenger RNA is higher in cancer and hypercoagulable diseases.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- The level of tissue factor in white blood cells is high in intravascular coagulation and several other diseases. "In a preliminary study, we have demonstrated that tissue factor (TF) is...

Delayed graft function worsens with reduced pressure reperfusion.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Delayed graft function appears to be worsened by reduced pressure reperfusion and improved by rinsing with Carolina rinse solution prior to reperfusion. "Despite extensive efforts in the fields of...

Microchimerism can be avoided by perfusing out donor kidney lymphocytes.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Microchimerism can be avoided by perfusing out donor kidney lymphocytes prior to transplantation. According to recent research from Norway, "After solid organ transplantation, donor lymphocytes...

Analysis: Neoral improves graft survival in living-donor transplant patients.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Novartis Pharmaceuticals Corp. (NVS) reported that the long-term survival rates of a transplanted kidney from a living donor appear to be significantly greater with cyclosporine-based immunosuppressive...

CCR7 mRNA is an independent predictor of lymph node metastasis in lung cancer.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- CCR7 mRNA is linked to a higher risk of lymph node metastasis in nonsmall cell lung cancer. "Tumor cell migration into the lymph nodes is an important aspect of cancer, yet little is known about the...

Divergence times for MHC-I genes in primates and humans show large differences.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- The divergence times of MHC class I genes in primates and humans has been calculated. According to a study from the United States, "The major histocompatibility complex (MHC) is a multigene family...

Campaign targets more than 5 million children.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- A measles vaccination and vitamin A campaign, targeting more than five million children aged between six months and 15 years, was launched in Ethiopia on June 6, 2003, by the United Nations Children's...

Initial clinical data reported from phase I/II trial of GVAX vaccine.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Cell Genesys, Inc., (CEGE) reported initial clinical data from a phase I/II trial of GVAX cancer vaccine for multiple myeloma, a type of bone marrow cancer, as well as positive interim results on a...

Prognosis is bad when pleural effusion is the first sign of IgD disease.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Prognosis is bad when pleural effusion is the first sign of IgD multiple myeloma. "Immunoglobulin D (IgD) multiple myeloma is rare, accounting for less than 2% of all patients with multiple myeloma....

Cannabis plant extract may alter TNF-alpha and IL-12, but no other cytokines.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Cannabis plant extract alters TNF-alpha and possibly IL-12, but no other cytokines, in MS patients. "Cannabinoids can modulate the function of immune cells. We here present the first human in vivo...

Some patients have autoreactive T cells to an acetylcholine receptor subunit.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Some myasthenia gravis patients with late onset and thymoma have autoreactive T cells to an acetylcholine receptor subunit. "In vitro T cell proliferative response to an alternative splicing...

Semaphorins aid nervous system development by serving mostly as chemorepellents.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Semaphorins are proteins that usually regulate nerve axon growth by serving as chemorepellents, but they also may signal many other interactions. According to a study from Germany, "The wiring of...

Endothelial cell inflammatory response to endotoxin needs actin polymerization.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Actin polymerization to produce stress fibers, ICAM-I and IL-8 expression are endothelial cell proinflammatory activities when challenged with endotoxin. "Endotoxin-induced intercellular adhesion...

Patients with symptoms similar to NBS do not have gene mutations in common.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Nijmegen breakage syndrome is symptomatic and not always due to the same gene mutations. According to recent research published in the journal Clinical Genetics, "Nijmegen breakage syndrome (NBS) is...

Adrenomedullin upregulation may promote pathophysiology of ophthalmic diseases.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Adrenomedullin expression may be linked to pathophysiology of various natural eye diseases, cancer, and is also stimulated by glucocorticoids. "Adrenomedullin (AM) is a multifunctional regulatory...

Disseminated Nocardia asteroides is a risk after trauma in the elderly.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- An elderly immunocompetent patient acquired disseminated Nocardia asteroides following mild arm trauma. According to published research from Czech Republic, "A case of disseminated infection with...

Mycobacterial taxonomy includes new, occasionally pathogenic members.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- New mycobacterial species are often discovered clinically; although rare, they must be considered during diagnosis. According to published research from Italy, "The advancement of genetic...

Immune cell testing used as adjunct to drug monitoring in transplantation patients.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Immune cell function testing can be used as an adjunct to therapeutic drug monitoring in transplantation patients. "Each year, 55,000 organ transplants are performed worldwide. Cumulatively, the...

Transplanted kidneys survive longer with combined immunosuppression therapy.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Novartis International AG reported a major new study of more than 7,000 living donor kidney transplant patients that finds the type of immunosuppressive therapy makes a difference to long-term outcome....

Combination treatment shown effective in kidney tranplant patients.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Results of a randomized, multi-center kidney transplant study comparing Prograf (tacrolimus)+ Sirolimus (Srl) vs Prograf + Mycophenolate Mofetil( (MMF) combination was presented at the 2003 American...

Bartonella bacilliformis IalB is expressed with low pH and temperature.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- The expression of IalB is altered following the environmental clues of pH and temperature change, but not in response to oxidative stress or hemin change, and relates to vector-host passage. ...

Fas-Fas ligand and CTLA-4 engagement cause T cell unresponsiveness in infection.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Paracoccidiomycosis is characterized by unresponsiveness to antigens that is found due to Fas-Fas ligand (CD95-CD95L) and cytotoxic T lymphocyte antigen-4 engagement. According to a study from...

Viral entry is due to VP4 capsid protein forming specific, charged ion channels.
July 2, 2003... 2003 JUL 2 - (NewsRx.com & NewsRx.net) -- Poliovirus entry is due to VP4 capsid protein being able to form specifically charged ion channel structures in the host membrane. According to recent research published in the Journal of Virology,...